A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive. [ MESH : D017628 http://www.ncbi.nlm.nih.gov/pubmed/16177057 GOC : add http://www.ncbi.nlm.nih.gov/pubmed/14612429 http://www.ncbi.nlm.nih.gov/pubmed/12430718 http://www.ncbi.nlm.nih.gov/pubmed/14561199 http://www.ncbi.nlm.nih.gov/pubmed/2089275 http://en.wikipedia.org/wiki/Microglia https://www.worldcat.org/search?q=bn%3A0721601464 http://www.ncbi.nlm.nih.gov/pubmed/19461673 GOC : dsd http://www.ncbi.nlm.nih.gov/pubmed/11517395 GOC : tfm ]
Term information
- FMA:54540
- BTO:0000962
- BTO:0000078
- FMA:54539
human_reference_atlas
- Unlike macroglial cells, microglial cells arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive.
- A central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive.
- brain macrophage
- brain-resident macrophage
- microgliocyte
- microglia
- hortega cells
- MF.microglia.CNS
- http://purl.obolibrary.org/obo/NCBITaxon_9606
Term relations
- glial cell and part of some central nervous system and has plasma membrane part some integrin alpha-M and has plasma membrane part some adhesion G protein-coupled receptor E1 and has plasma membrane part some macrosialin and capable of some innate immune response
- central nervous system macrophage
- material anatomical entity
- glial cell
- has plasma membrane part some integrin alpha-M
- develops from some mesodermal cell
- develops from some (
stem cell and
part of some yolk sac) - has plasma membrane part some macrosialin
- has plasma membrane part some adhesion G protein-coupled receptor E1
- capable of some innate immune response