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mast cell

^ http://purl.obolibrary.org/obo/CL_0000097


A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development. [ MESH:D008407 http://www.ncbi.nlm.nih.gov/sites/entrez?db=pmc&cmd=search&term=PMC2855166 http://www.ncbi.nlm.nih.gov/sites/entrez?db=pmc&cmd=search&term=PMC1312421 http://www.ncbi.nlm.nih.gov/pubmed/16455980 http://openisbn.com/search.php?q=068340007X&isbn=1/ http://www.ncbi.nlm.nih.gov/pubmed/19671378 GOC:add http://www.ncbi.nlm.nih.gov/pubmed/9354811 http://www.ncbi.nlm.nih.gov/pubmed/15153310 GOC:dsd GOC:tfm MESH:A11.329.427 http://www.ncbi.nlm.nih.gov/pubmed/212366338 ]

Synonyms: histaminocyte, labrocyte, mastocyte

Term info

database cross reference
  • FMA:66784
  • CALOHA:TS-0603
  • BTO:0000830
comment

Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5.

has related synonym

tissue basophil

Term relations

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