A rare, autosomal recessive syndrome caused by mutations in the WRN gene. It is characterized by the appearance of accelerated aging following puberty. It is associated with the development of diabetes mellitus, atherosclerosis, cataracts, and cancer. [ NCI ]

Synonyms: Werner Syndrome Werner's Syndrome Werner syndrome WS Adult Progeria adult progeria

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Term information

Subsets

NCIT_C165258

ALT DEFINITION

An inherited disorder marked by rapid aging that begins in early adolescence. Patients may be shorter than average, and have health problems such as loss and graying of hair, hardening of the arteries, thinning of the bones, diabetes, and thin, hardened skin. They also have an increased risk of cancer, especially osteosarcoma (a type of bone cancer). Adult progeria is caused by a mutation (change) in a gene involved in cell division. It is a type of autosomal recessive gene disease.

Contributing Source

Cellosaurus

Legacy Concept Name

Werner_Syndrome

Preferred Name

Werner Syndrome

Semantic Type

Disease or Syndrome

UMLS CUI

C0043119

code

C3447