Werner SyndromeGo to external page http://purl.obolibrary.org/obo/NCIT_C3447
A rare, autosomal recessive syndrome caused by mutations in the WRN gene. It is characterized by the appearance of accelerated aging following puberty. It is associated with the development of diabetes mellitus, atherosclerosis, cataracts, and cancer. [ NCI ]
Synonyms: Werner Syndrome Werner's Syndrome Werner syndrome WS Adult Progeria adult progeria
An inherited disorder marked by rapid aging that begins in early adolescence. Patients may be shorter than average, and have health problems such as loss and graying of hair, hardening of the arteries, thinning of the bones, diabetes, and thin, hardened skin. They also have an increased risk of cancer, especially osteosarcoma (a type of bone cancer). Adult progeria is caused by a mutation (change) in a gene involved in cell division. It is a type of autosomal recessive gene disease.
Disease or Syndrome
- DNA Repair Disorder and Hereditary Neoplastic Syndrome and Disease_Has_Molecular_Abnormality some WRN Gene Mutation and Disease_May_Have_Associated_Disease some Hematopoietic and Lymphoid Cell Neoplasm and Disease_May_Have_Associated_Disease some Melanoma and Disease_May_Have_Associated_Disease some Meningioma and Disease_May_Have_Associated_Disease some Thyroid Gland Carcinoma and Disease_May_Have_Associated_Disease some Osteosarcoma and Disease_May_Have_Associated_Disease some Soft Tissue Sarcoma and Disease_Mapped_To_Chromosome some Chromosome 8 and Disease_Mapped_To_Gene some WRN Gene