Alzheimer's disease
http://www.ebi.ac.uk/efo/EFO_0000249
A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
A dementia which is an incurable disease of unknown cause, starting in late middle age or in old age, that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood, that leads in advanced cases to a profound decline in cognitive and physical functioning, and that is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid.
A dementia that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting in late middle age and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.
Synonyms: Disease, Alzheimer, Dementia in Alzheimer's disease, unspecified (disorder), Presenile Alzheimer Dementia, ALZHEIMERS DIS, Alzheimers, sporadic Alzheimer's disease, DAT - Dementia Alzheimer's type, Dementia in Alzheimer's disease, Alzheimer's disease, NOS, Alzheimer Dementia, Presenile, Dementia, Alzheimer Type, Alzheimer Dementia, Alzheimer's Dementia, Alzheimer's, Dementia, Presenile, [X]Dementia in Alzheimer's disease (disorder), ALZHEIMER DIS, AD, [X]Dementia in Alzheimer's disease, AD - Alzheimer's disease, Disease, Alzheimer's, Alzheimer Disease, Dementia, Presenile Alzheimer, Alzheimer Type Dementia, Dementia in Alzheimer's disease (disorder), Alzheimer's disease (disorder), Alzheimers Dementia, Alzheimers disease, Dementia of the Alzheimer's type
Term info
DOID:10652
ICD9:290.1, ICD9:331.0
MSH:D000544
NCIt:C38778, NCIt:C34524, NCIt:C2866
NIFSTD:birnlex_2092
OMIM:605526, OMIM:615711, OMIM:502500, OMIM:615590, OMIM:104300, OMIM:608907
SNOMEDCT:12348006, SNOMEDCT:26929004, SNOMEDCT:15662003
Alzheimer Disease, Late Onset[accessedResource: MSH:D000544][accessDate: 05-04-2011], Alzheimer's[accessedResource: NIFSTD:birnlex_2092][accessDate: 05-04-2011], [X]Dementia in Alzheimer's disease, unspecified (disorder)[accessedResource: SNOMEDCT:192164001][accessDate: 05-04-2011], Dementias, Senile[accessedResource: MSH:D000544][accessDate: 05-04-2011], Dementia of the Alzheimer's type[accessedResource: DOID:10652][accessDate: 05-04-2011], Senile Dementias[accessedResource: MSH:D000544][accessDate: 05-04-2011], Alzheimers disease[accessedResource: NIFSTD:birnlex_2092][accessDate: 05-04-2011], Dementia in Alzheimer's disease, unspecified (disorder)[accessedResource: DOID:10652][accessDate: 05-04-2011], Alzheimer Senile Dementia[accessedResource: NIFSTD:birnlex_2092][accessDate: 05-04-2011], A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)[accessedResource: MSH:D000544][accessDate: 05-04-2011], Alzheimer Type Dementia[accessedResource: MSH:D000544][accessDate: 05-04-2011], ALZHEIMER DIS LATE ONSET[accessedResource: MSH:D000544][accessDate: 05-04-2011], AD[accessedResource: DOID:10652][accessDate: 05-04-2011], FOCAL ONSET ALZHEIMERS DIS[accessedResource: MSH:D000544][accessDate: 05-04-2011], Dementia, Senile[accessedResource: MSH:D000544][accessDate: 05-04-2011], Alzheimer's Disease, Focal Onset[accessedResource: MSH:D000544][accessDate: 05-04-2011], EARLY ONSET ALZHEIMER DIS[accessedResource: MSH:D000544][accessDate: 05-04-2011], Dementia in Alzheimer's disease (disorder)[accessedResource: DOID:10652][accessDate: 05-04-2011], Alzheimer's Dementia[accessedResource: NIFSTD:birnlex_2092][accessDate: 05-04-2011], AD - Alzheimer's disease[accessedResource: SNOMEDCT:26929004][accessDate: 05-04-2011], Primary Senile Degenerative Dementia[accessedResource: MSH:D000544][accessDate: 05-04-2011], Focal Onset Alzheimer's Disease[accessedResource: MSH:D000544][accessDate: 05-04-2011], Alzheimer Disease, Early Onset[accessedResource: MSH:D000544][accessDate: 05-04-2011], Acute Confusional Senile Dementia[accessedResource: MSH:D000544][accessDate: 05-04-2011], Alzheimers[accessedResource: NIFSTD:birnlex_2092][accessDate: 05-04-2011], [X]Dementia in Alzheimer's disease, unspecified[accessedResource: SNOMEDCT:192164001][accessDate: 05-04-2011], Alzheimer dementia[accessedResource: NCIt:C2866][accessDate: 05-04-2011], Dementias, Presenile[accessedResource: MSH:D000544][accessDate: 05-04-2011], Alzheimer Disease[accessedResource: MSH:D000544][accessDate: 05-04-2011], Alzheimer Dementia, Presenile[accessedResource: MSH:D000544][accessDate: 05-04-2011], LATE ONSET ALZHEIMER DIS[accessedResource: MSH:D000544][accessDate: 05-04-2011], Early Onset Alzheimer Disease[accessedResource: MSH:D000544][accessDate: 05-04-2011], Presenile Dementia[accessedResource: MSH:D000544][accessDate: 05-04-2011], ALZHEIMER DIS[accessedResource: MSH:D000544][accessDate: 05-04-2011], Dementia, Presenile Alzheimer[accessedResource: MSH:D000544][accessDate: 05-04-2011], [X]Dementia in Alzheimer's disease (disorder)[accessedResource: SNOMEDCT:192160005][accessDate: 05-04-2011], Presenile Alzheimer Dementia[accessedResource: MSH:D000544][accessDate: 05-04-2011], Alzheimer's Disease Pathway KEGG[accessedResource: NCIt:C38778][accessDate: 05-04-2011], Senile Dementia, Acute Confusional[accessedResource: MSH:D000544][accessDate: 05-04-2011], Presenile Dementias[accessedResource: MSH:D000544][accessDate: 05-04-2011], ALZHEIMERS DIS[accessedResource: MSH:D000544][accessDate: 05-04-2011], Disease, Alzheimer[accessedResource: MSH:D000544][accessDate: 05-04-2011], Disease, Alzheimer's[accessedResource: MSH:D000544][accessDate: 05-04-2011], Late Onset Alzheimer Disease[accessedResource: MSH:D000544][accessDate: 05-04-2011], Alzheimer's disease (disorder)[accessedResource: DOID:10652][accessDate: 05-04-2011], Alzheimer Type Senile Dementia[accessedResource: MSH:D000544][accessDate: 05-04-2011], Dementia in Alzheimer's disease[accessedResource: SNOMEDCT:192160005][accessDate: 05-04-2011], ALZHEIMER DIS EARLY ONSET[accessedResource: MSH:D000544][accessDate: 05-04-2011], [X]Dementia in Alzheimer's disease[accessedResource: SNOMEDCT:192160005][accessDate: 05-04-2011], Dementia, Primary Senile Degenerative[accessedResource: MSH:D000544][accessDate: 05-04-2011], A dementia that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting in late middle age and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability.[accessedResource: DOID:10652][accessDate: 05-04-2011], Senile Dementia[accessedResource: MSH:D000544][accessDate: 05-04-2011], Senile Dementia, Alzheimer Type[accessedResource: MSH:D000544][accessDate: 05-04-2011], Dementia, Alzheimer Type[accessedResource: MSH:D000544][accessDate: 05-04-2011], ALZHEIMERS DIS FOCAL ONSET[accessedResource: MSH:D000544][accessDate: 05-04-2011], Alzheimer's disease, NOS[accessedResource: SNOMEDCT:26929004][accessDate: 05-04-2011], Dementia, Presenile[accessedResource: MSH:D000544][accessDate: 05-04-2011], Alzheimers Dementia[accessedResource: DOID:10652][accessDate: 05-04-2011], A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.[accessedResource: NCIt:C2866][accessDate: 05-04-2011], DAT - Dementia Alzheimer's type[accessedResource: SNOMEDCT:192160005][accessDate: 05-04-2011]
http://www.ncbi.nlm.nih.gov/pubmed/25687773
true
James Malone, Tomasz Adamusiak
Term relations
- tauopathy
- realized_in some (
disease course and
has part some microtubule-associated protein tau) - realized_in some (
disease course and
has part some neurodegeneration) - has_disease_location some central nervous system
- plasma beta-amyloid 1-40 measurement
- plasma beta-amyloid 1-42 measurement
- neuritic plaque measurement
- left inferior lateral ventricle volume measurement
- t-tau:beta-amyloid 1-42 ratio measurement
- p-tau:beta-amyloid 1-42 ratio measurement
- cerebral amyloid deposition measurement
- amyloid-beta measurement
- plasma clusterin measurement
- cerebrospinal fluid clusterin measurement
- amyloid plaque accumulation rate
- cortical thickness
- caudate nucleus volume
- interleukin-6 receptor measurement
- beta-amyloid 1-42 measurement
- p-tau measurement
- t-tau measurement
- matrix metalloproteinase measurement
- CCL4 measurement
- CCL2 measurement
- beta-secretase 1 measurement
- neurofilament light chain measurement
- family history of Alzheimer’s disease