^ http://purl.obolibrary.org/obo/CL_0000312

An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell. [ MESH:A11.436.397 MESH:D015603 http://en.wikipedia.org/wiki/Keratinocyte http://www.ncbi.nlm.nih.gov/pubmed/19727116 http://www.ncbi.nlm.nih.gov/pubmed/15582983 http://www.ncbi.nlm.nih.gov/pubmed/15749908 GOC:dsd ]

Synonyms: malpighian cell, keratinized cell of epidermis

Term info

database cross reference

Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive.

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