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hematopoietic stem cell

^ http://purl.obolibrary.org/obo/CL_0000037


A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. [ http://en.wikipedia.org/wiki/Hematopoietic_stem_cell http://www.ncbi.nlm.nih.gov/pubmed/19022770 GOC:add GOC:dsd GOC:tfm ]

Synonyms: blood forming stem cell, HSC, hemopoietic stem cell

Term info

database cross reference
  • CALOHA:TS-0448
  • VHOG:0001485
  • FMA:86475
  • BTO:0000725
  • FMA:70337
comment

Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative.

has related synonym

colony forming unit hematopoietic

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