{"links":{"first":"https://www.ebi.ac.uk/metagenomics/api/v1/samples/SRS732232/studies?format=json&page=1","last":"https://www.ebi.ac.uk/metagenomics/api/v1/samples/SRS732232/studies?format=json&page=1","next":null,"prev":null},"data":[{"type":"studies","id":"MGYS00002264","attributes":{"bioproject":"PRJNA264728","accession":"MGYS00002264","samples-count":7,"is-private":false,"last-update":"2020-12-08T10:07:14","secondary-accession":"SRP049210","centre-name":"JCVI","public-release-date":null,"study-abstract":"Dental caries, one of the most globally widespread infectious diseases is intimately linked to pH dynamics. In supragingival plaque, after the addition of a carbohydrate source, bacteria rapidly decrease the pH which then subsequently recovers. In this project we studied gene transcription in naturally diverse saliva-derived in vitro grown biofilms as they were amended with sugar (corresponding to a dietary intake of carbohydrates). We applied an in vitro biofilm model system that was previously determined to be functionally and taxonomically robust and representative of health-associated dental plaque. The major goal was to characterize critical gene expression mechanisms supporting the understudied pH-recovery stage associated with health. This study provides a solid baseline for defining healthy and disease-like states and highlights the power of moving beyond single and dual species applications to capture key players and their orchestrated metabolic activities within a human oral microbiome model.","study-name":"Gene expression anlayses of saliva-derived in vitro biofilms during carbohydrate fermentation and pH stress","data-origination":"HARVESTED"},"relationships":{"analyses":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00002264/analyses?format=json"}},"publications":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00002264/publications?format=json"}},"biomes":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00002264/biomes?format=json"},"data":[{"type":"biomes","id":"root:Host-associated:Arthropoda:Digestive system:Oral:Saliva","links":{"self":"https://www.ebi.ac.uk/metagenomics/api/v1/biomes/root:Host-associated:Arthropoda:Digestive%20system:Oral:Saliva?format=json"}}]},"downloads":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00002264/downloads?format=json"}},"geocoordinates":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00002264/geocoordinates?format=json"}},"samples":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00002264/samples?format=json"}}},"links":{"self":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00002264?format=json"}}],"meta":{"pagination":{"page":1,"pages":1,"count":1}}}