{"links":{"first":"https://www.ebi.ac.uk/metagenomics/api/v1/samples/SRS1223402/studies?format=json&page=1","last":"https://www.ebi.ac.uk/metagenomics/api/v1/samples/SRS1223402/studies?format=json&page=1","next":null,"prev":null},"data":[{"type":"studies","id":"MGYS00001252","attributes":{"samples-count":157,"accession":"MGYS00001252","bioproject":"PRJNA306884","is-private":false,"last-update":"2016-10-04T16:29:21","secondary-accession":"SRP067761","centre-name":"University of Michigan","public-release-date":null,"study-abstract":"Colonic bacteria produce the health-promoting metabolite butyrate. We sought to influence butyrate production in 20 healthy adults by supplementing their diet with resistant starch (RS). While average fecal butyrate increased from 8 to 12 mmol/kg wet feces, responses varied widely between individuals. Three types of responses were categorized: enhanced, high, and low (n = 11, 3, and 6 respectively). Fecal butyrate increased by 87% in the enhanced group, while it remained =12 mmol/kg in the high group and =8 mmol/kg in the low group. Microbiome analyses revealed that RS-degrading organisms increased from ~ 2 to 10% in the enhanced and high groups, but remained at ~ 2% in the low group. This lack of increase in RS-degrading microbes is likely why individuals in the low group do not benefit in butyrate with RS. This study underscores the importance of understanding inter-individual variability in managing ecosystem services from microbiomes.","study-name":"Managing human microbiomes: Explaining heterogeneous responses in butyrate to dietary supplementation with resistant starch","data-origination":"HARVESTED"},"relationships":{"analyses":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00001252/analyses?format=json"}},"samples":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00001252/samples?format=json"}},"biomes":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00001252/biomes?format=json"},"data":[{"type":"biomes","id":"root:Host-associated:Human:Digestive system:Large intestine:Fecal","links":{"self":"https://www.ebi.ac.uk/metagenomics/api/v1/biomes/root:Host-associated:Human:Digestive%20system:Large%20intestine:Fecal?format=json"}}]},"geocoordinates":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00001252/geocoordinates?format=json"}},"publications":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00001252/publications?format=json"}},"downloads":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00001252/downloads?format=json"}}},"links":{"self":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00001252?format=json"}}],"meta":{"pagination":{"page":1,"pages":1,"count":1}}}