{"links":{"first":"https://www.ebi.ac.uk/metagenomics/api/v1/samples/ERS765152/studies?format=json&page=1","last":"https://www.ebi.ac.uk/metagenomics/api/v1/samples/ERS765152/studies?format=json&page=1","next":null,"prev":null},"data":[{"type":"studies","id":"MGYS00001786","attributes":{"bioproject":"PRJEB9488","accession":"MGYS00001786","samples-count":25,"is-private":false,"last-update":"2017-06-05T13:19:24","secondary-accession":"ERP010597","centre-name":"WASHINGTON UNIVERSITY  SCHOOL OF MEDICINE","public-release-date":null,"study-abstract":"Identifying interventions that more effectively promote healthy growth of children with undernutrition is a pressing global health goal. Analysis of human milk oligosaccharides (HMOs) from 6-month postpartum mothers in two Malawian birth-cohorts revealed that sialylated HMOs are significantly less abundant in mothers with severely stunted infants. To explore this association, we colonized young germ-free mice with a consortium of bacterial strains cultured from the fecal microbiota of a 6-month old stunted Malawian infant and fed recipient animals a prototypic Malawian diet with or without purified sialylated bovine milk oligosaccharides (S-BMO). S-BMO produced a microbiota-dependent augmentation of lean body mass gain, changed bone morphology and altered liver, muscle and brain metabolism in ways indicative of a greater ability to utilize nutrients for anabolism. These effects were also documented in gnotobiotic piglets using the same consortium and Malawian diet. These preclinical models establish a causal microbiota-dependent relationship between S-BMO and growth promotion.","study-name":"Sialylated milk glycans promote growth in gnotobiotic mice and pigs with a stunted Malawian infant gut microbiota","data-origination":"SUBMITTED"},"relationships":{"analyses":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00001786/analyses?format=json"}},"publications":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00001786/publications?format=json"}},"biomes":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00001786/biomes?format=json"},"data":[{"type":"biomes","id":"root:Host-associated:Mammals:Digestive system:Large intestine:Fecal","links":{"self":"https://www.ebi.ac.uk/metagenomics/api/v1/biomes/root:Host-associated:Mammals:Digestive%20system:Large%20intestine:Fecal?format=json"}}]},"downloads":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00001786/downloads?format=json"}},"geocoordinates":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00001786/geocoordinates?format=json"}},"samples":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00001786/samples?format=json"}}},"links":{"self":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00001786?format=json"}}],"meta":{"pagination":{"page":1,"pages":1,"count":1}}}