{"links":{"first":"https://www.ebi.ac.uk/metagenomics/api/v1/samples/ERS3901607/studies?format=json&page=1","last":"https://www.ebi.ac.uk/metagenomics/api/v1/samples/ERS3901607/studies?format=json&page=1","next":null,"prev":null},"data":[{"type":"studies","id":"MGYS00005557","attributes":{"samples-count":90,"accession":"MGYS00005557","bioproject":"PRJEB34659","is-private":false,"last-update":"2020-07-24T12:56:56","secondary-accession":"ERP117596","centre-name":"SRUC","public-release-date":null,"study-abstract":"Obesity is an important equine welfare issue. Dietary restriction is the most effective weight-loss tool, although individual animals range in their weight-loss propensity. Gastrointestinal-derived bacteria play a fundamental role in host-health and have been associated with obesity and weight-loss in other species. This study evaluated the faecal microbiome (next-generation sequencing of 16S rRNA genes) of 15 obese Welsh Mountain pony mares, across 2 years (n = 8 Year 1; n = 7 Year 2) before and after a 7-week period of dietary restriction (1% body mass hay as daily dry matter intake).  Losses in body mass ranged from 7.11% to 11.59%. Changes in the faecal microbiome composition following weight-loss included a reduction in the relative abundance of Firmicutes and Tenericutes and a reduction in indices of bacterial diversity. Pre-diet diversity was negatively associated with weight-loss. Pre-diet faecal acetate concentration was a strong predictor of subsequent weight-loss and negatively associated with Sphaerochaeta (Spirochaetes phyla) abundance. These data support a role for the faecal microbiome in weight-loss propensity in ponies and provide a baseline for research evaluating elements of the faecal microbiome in predicting weight-loss success in larger cohorts","study-name":"The equine gastrointestinal microbiome: Impacts of weight-loss","data-origination":"SUBMITTED"},"relationships":{"analyses":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00005557/analyses?format=json"}},"samples":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00005557/samples?format=json"}},"biomes":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00005557/biomes?format=json"},"data":[{"type":"biomes","id":"root:Host-associated:Mammals:Digestive system:Fecal","links":{"self":"https://www.ebi.ac.uk/metagenomics/api/v1/biomes/root:Host-associated:Mammals:Digestive%20system:Fecal?format=json"}}]},"geocoordinates":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00005557/geocoordinates?format=json"}},"publications":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00005557/publications?format=json"}},"downloads":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00005557/downloads?format=json"}}},"links":{"self":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00005557?format=json"}}],"meta":{"pagination":{"page":1,"pages":1,"count":1}}}