{"links":{"first":"https://www.ebi.ac.uk/metagenomics/api/v1/samples/ERS2536421/studies?format=json&page=1","last":"https://www.ebi.ac.uk/metagenomics/api/v1/samples/ERS2536421/studies?format=json&page=1","next":null,"prev":null},"data":[{"type":"studies","id":"MGYS00002413","attributes":{"bioproject":"PRJEB27188","accession":"MGYS00002413","samples-count":173,"is-private":false,"last-update":"2018-06-13T09:22:29","secondary-accession":"ERP109242","centre-name":"Nord University","public-release-date":null,"study-abstract":"Prebiotics are food/feed additives intended to sculpt gut microbial communities as they are selectively utilized by the microorganisms to exert beneficial health effects on hosts. Macroalga-derived oligosaccharides are potential prebiotics, and herein, we determined the effects of Laminaria sp.-derived alginate oligosaccharide (AlgOS) on the distal intestinal microbiota of Atlantic salmon (Salmo salar). Using a high-throughput 16S rRNA gene amplicon sequencing technique, we investigated the microbiota harboured in the intestinal content and mucus of Atlantic salmon offered feeds supplemented with 0.5 and 2.5% AlgOS. We found that AlgOS shifts the intestinal microbiota profile; alpha diversity was significantly reduced with 2.5% AlgOS while with 0.5% AlgOS the alteration occurred without impacting the bacterial diversity. Beta diversity showed a significant difference between control and AlgOS-fed groups. AlgOS supplementation facilitated the dominance of Proteobacteria and Spirochaetes, promoting the growth of presumed butyrate producers in the intestine. In addition, 0.5% AlgOS stimulated certain bacteria belonging to Proteobacteria, Spirochaetes and Actinobacteria. This indicates that the low inclusion of AlgOS can plausibly induce a prebiotic effect on the distal intestinal microbiota of Atlantic salmon. These results are expected to generate further interest in the potential of macroalgae-derived oligosaccharides as prebiotics for food and feed applications.  ","study-name":"Alginate oligosaccharide-induced shift in the intestinal microbiota of salmon.","data-origination":"SUBMITTED"},"relationships":{"analyses":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00002413/analyses?format=json"}},"publications":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00002413/publications?format=json"}},"biomes":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00002413/biomes?format=json"},"data":[{"type":"biomes","id":"root:Host-associated:Fish:Digestive system:Intestine","links":{"self":"https://www.ebi.ac.uk/metagenomics/api/v1/biomes/root:Host-associated:Fish:Digestive%20system:Intestine?format=json"}}]},"downloads":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00002413/downloads?format=json"}},"geocoordinates":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00002413/geocoordinates?format=json"}},"samples":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00002413/samples?format=json"}}},"links":{"self":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00002413?format=json"}}],"meta":{"pagination":{"page":1,"pages":1,"count":1}}}