{"links":{"first":"https://www.ebi.ac.uk/metagenomics/api/v1/samples/ERS1623821/studies?format=json&page=1","last":"https://www.ebi.ac.uk/metagenomics/api/v1/samples/ERS1623821/studies?format=json&page=1","next":null,"prev":null},"data":[{"type":"studies","id":"MGYS00005512","attributes":{"bioproject":"PRJEB20104","accession":"MGYS00005512","samples-count":779,"is-private":false,"last-update":"2020-06-06T21:49:10","secondary-accession":"ERP022226","centre-name":"UNIVERSITY OF HELSINKI","public-release-date":null,"study-abstract":"BACKGROUND:Atopic allergy has been more common among schoolchildren in Finland, as compared to Russian Karelia. These adjacent regions show one of the most contrasting socio-economical differences in the world.OBJECTIVE:We explored changes in allergy from school age to young adulthood from 2003 to 2010/2012 in these two areas. The skin and nasal microbiota were also compared.METHODS:Randomly selected children from Finnish (n = 98) and Russian Karelia (n = 82) were examined in 2003, when the children were 7-11 years of age, and again in 2010 (Finnish Karelia) and 2012 (Russian Karelia). We analysed self-reported allergy symptoms and sensitization to common allergens by serum sIgE values. The skin (volar forearm) and nasal mucosa microbiota, collected in 2012 (aged 15-20 years), identified from DNA samples, were compared with multivariate methods.RESULTS:Asthma, hay fever, atopic eczema, self-reported rhinitis, as well as atopic sensitization, were threefold to 10-fold more common in Finland, as compared to Russian Karelia. Hay fever and peanut sensitization were almost non-existent in Russia. These patterns remained throughout the 10-year follow-up. Skin microbiota, as well as bacterial and fungal communities in nasal mucosa, was contrastingly different between the populations, best characterized by the diversity and abundance of genus Acinetobacter; more abundant and diverse in Russia. Overall, diversity was significantly higher among Russian subjects (Pskin < 0.0001, Pnasal-bacteria < 0.0001 and Pnasal-fungi < 0.01). Allergic diseases were not associated with microbial diversity in Finnish subjects.CONCLUSIONS AND CLINICAL RELEVANCE:Differences in allergic phenotype, developed in early life, remain between populations. A parallel difference in the composition of skin and nasal microbiota suggests a potential underlying mechanism. Our results also suggest that high abundance and diversity of Acinetobacter might contribute to the low allergy prevalence in Russia. Implications of early-life exposure to Acinetobacter should be further investigated.","study-name":"Significant disparities in allergy prevalence and microbiota between the young people in Finnish and Russian Karelia.","data-origination":"SUBMITTED"},"relationships":{"samples":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00005512/samples?format=json"}},"biomes":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00005512/biomes?format=json"},"data":[{"type":"biomes","id":"root:Host-associated:Human","links":{"self":"https://www.ebi.ac.uk/metagenomics/api/v1/biomes/root:Host-associated:Human?format=json"}}]},"downloads":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00005512/downloads?format=json"}},"analyses":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00005512/analyses?format=json"}},"publications":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00005512/publications?format=json"}},"geocoordinates":{"links":{"related":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00005512/geocoordinates?format=json"}}},"links":{"self":"https://www.ebi.ac.uk/metagenomics/api/v1/studies/MGYS00005512?format=json"}}],"meta":{"pagination":{"page":1,"pages":1,"count":1}}}