Substrates for peptidase S9G.064: archealysin

Summary Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Angiotensinogen P01019 34-41 Peptide-Tyr37+Ile-Peptide N NT Asp Arg Val Tyr Ile His Pro Phe Cowan et al., 1987
Bz-Phe-Val-Arg-NHPhNO2 Bz-Phe-Val-Arg+NHPhNO2 S - Phe Val Arg NAN - - - Cowan et al., 1987
D-Phe-Phe-Arg-NHMec D-Phe-Phe-Arg+NHMec S - DPh Phe Arg AMC - - - Chao, 1998
D-Val-Leu-Arg-NHMec D-Val-Leu-Arg+NHMec S - DVa Leu Arg AMC - - - Chao, 1998
Glu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn (serum thymic factor) Glu-Ala-Lys-Ser+Gln-Gly-Gly-Ser S NT Glu Ala Lys Ser Gly Gly Ser - Cowan et al., 1987
Insulin B chain (Oxidised) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N NT Leu Val Glu Ala Leu Tyr Leu Val Cowan et al., 1987
Insulin B chain (Oxidised) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu+Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N NT Val Glu Ala Leu Tyr Leu Val Cya Cowan et al., 1987
Insulin B chain (Oxidised) P01317 25-54 Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala N NT Glu Ala Leu Tyr Leu Val Cya Gly Cowan et al., 1987