Substrates for peptidase M13.002: endothelin-converting enzyme 1
Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.
Substrate | Uniprot | Residue range | Cleavage Site | Cleavage type | Evidence | P4 | P3 | P2 | P1 | P1' | P2' | P3' | P4' | Reference | CutDB | MERNUM |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
beta-amyloid protein 42 | P05067 | 672-713 | peptide-Glu674+Phe-peptide | P | - | Asp | Ala | Glu | Phe | Arg | His | Asp | Yan et al., 2006 | |||
insulin B-chain (oxidized) | P01317 | 25-54 | Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu+Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala | N | NT | Val | Glu | Ala | Leu | Tyr | Leu | Val | Cya | Johnson et al., 1999 | ||
neurotensin | P30990 | 151-163 | Glp-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro+Tyr-Ile-Leu | N | Pro | Arg | Arg | Pro | Tyr | Ile | Leu | - | Ahn & Johnson, 2004 | 17023 | ||
angiotensin-1 | P01019 | 34-43 | Asp-Arg-Val+Tyr-Ile-His-Pro-Phe-His-Leu | N | - | Asp | Arg | Val | Tyr | Ile | His | Pro | Carson et al., 2002 | 24225 | ||
endothelin-1 | P05305 | 53-73 | peptide-Ile71+Ile-peptide | P | His | Leu | Asp | Ile | Ile | Trp | Val | Asn | Fahnoe et al., 2000 | 3734 | ||
substance P | P20366 | 58-68 | Arg-Pro-Lys-Pro-Gln-Gln+Phe-Phe-Gly-Leu-Met-NH2 | N | Lys | Pro | Gln | Gln | Phe | Phe | Gly | Leu | Carson et al., 2002 | 17024 | ||
beta-amyloid protein 42 | P05067 | 672-713 | peptide-Lys687+Leu-peptide | P | His | His | Gln | Lys | Leu | Val | Phe | Phe | Yan et al., 2006 | |||
substance P | P20366 | 58-68 | Arg-Pro-Lys-Pro-Gln-Gln-Phe+Phe-Gly-Leu-Met-NH2 | N | Pro | Gln | Gln | Phe | Phe | Gly | Leu | Met | Ahn & Johnson, 2004 | 17025 | ||
neurotensin | P30990 | 151-163 | Glp-Leu+Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu | N | - | - | Glp | Leu | Tyr | Glu | Asn | Lys | Carson et al., 2002 | 24220 | ||
insulin B-chain (oxidized) | P01317 | 25-54 | Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala+Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala | N | NT | Leu | Val | Glu | Ala | Leu | Tyr | Leu | Val | Johnson et al., 1999 | ||
big endothelin 1 | P05305 | 53-90 | peptide-His79+Val-peptide | P | Thr | Pro | Glu | His | Val | Val | Pro | Tyr | Fahnoe et al., 2000 | 3735 | ||
insulin B-chain (oxidized) | P01317 | 25-54 | Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu+Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala | N | NT | Gly | Ser | His | Leu | Val | Glu | Ala | Leu | Johnson et al., 1999 | ||
angiotensin-1 | P01019 | 34-43 | Asp-Arg-Val-Tyr-Ile-His-Pro+Phe-His-Leu | N | Tyr | Ile | His | Pro | Phe | His | Leu | Val | Carson et al., 2002 | 24223 | ||
big endothelin 3 precursor | P14138 | 17-238 | peptide-Trp21+Ile22-peptide | P | Asp | Ile | Ile | Trp | Ile | Asn | Thr | Pro | Ahn & Johnson, 2004 | 17020 | ||
big endothelin 1 | P05305 | 53-90 | peptide-Trp21+Val22-peptide | P | Asp | Ile | Ile | Trp | Val | Asn | Thr | Pro | Ahn & Johnson, 2004 | |||
endothelin-2 precursor | P20800 | 25-178 | peptide-Trp21+Val22-peptide | P | Asp | Ile | Ile | Trp | Val | Asn | Thr | Pro | Fahnoe et al., 2000 | 17019 | ||
endothelin-1 | P05305 | 53-73 | peptide-Asp70+Ile-peptide | P | Cys | His | Leu | Asp | Ile | Ile | Trp | Val | Fahnoe et al., 2000 | 3733 | ||
big endothelin 1 | P05305 | 53-90 | peptide-Gly86+Ser-peptide | P | Tyr | Gly | Leu | Gly | Ser | Pro | Arg | Ser | Fahnoe et al., 2000 | 3736 | ||
insulin B-chain (oxidized) | P01317 | 25-54 | Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr+Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala | N | NT | Glu | Ala | Leu | Tyr | Leu | Val | Cya | Gly | Johnson et al., 1999 | ||
endothelin-1 precursor | Q6FH53 | 17-212 | peptide-Arg92+Ala-peptide | P | Arg | Ser | Lys | Arg | Ala | Leu | Glu | Asn | Kido et al., 1998 | 3729 | ||
endothelin-1 precursor | Q6FH53 | 17-212 | peptide-Arg52+Cys-peptide | P | Arg | Ser | Lys | Arg | Cys | Ser | Cys | Ser | Kido et al., 1998 | 3728 | ||
beta-amyloid protein 42 | P05067 | 672-713 | peptide-Leu688+Val-peptide | P | His | Gln | Lys | Leu | Val | Phe | Phe | Ala | Yan et al., 2006 | |||
substance P | P20366 | 58-68 | Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly+Leu-Met-NH2 | N | Gln | Phe | Phe | Gly | Leu | Met | NH2 | - | Carson et al., 2002 | 24209 | ||
Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala+Phe-Lys-Dnp | Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala+Phe-Lys-Dnp | S | Gly | Phe | Ser | Ala | Phe | Lys | DNP | - | Ahn & Johnson, 2004 | |||||
insulin B-chain (oxidized) | P01317 | 25-54 | Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His+Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala | N | NT | Cya | Gly | Ser | His | Leu | Val | Glu | Ala | Johnson et al., 1999 | ||
bradykinin | P01042 | 381-389 | Arg-Pro-Pro-Gly-Phe-Ser-Pro+Phe-Arg | N | Gly | Phe | Ser | Pro | Phe | Arg | - | - | Ahn & Johnson, 2004 | 17021 | ||
KNG1 kininogen 1 isoform 1 | Q6PAU9 | 1-644 | peptide-Pro387+Phe-peptide | P | Gly | Phe | Ser | Pro | Phe | Arg | Ser | Ser | Carson et al., 2002 | 24192 | ||
endothelin-1 | P05305 | 53-73 | peptide-Ser57+Leu-peptide | P | Ser | Cys | Ser | Ser | Leu | Met | Asp | Lys | Fahnoe et al., 2000 | 3730 | ||
endothelin-1 | P05305 | 53-73 | peptide-Phe66+Cys-peptide | P | Cys | Val | Tyr | Phe | Cys | His | Leu | Asp | Fahnoe et al., 2000 | 3732 | ||
insulin B-chain (oxidized) | P01317 | 25-54 | Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr+Pro-Lys-Ala | N | NT | Phe | Phe | Tyr | Thr | Pro | Lys | Ala | - | Johnson et al., 1999 | ||
insulin B-chain (oxidized) | P01317 | 25-54 | Phe-Val-Asn-Gln-His-Leu-Cya-Gly-Ser-His-Leu-Val-Glu+Ala-Leu-Tyr-Leu-Val-Cya-Gly-Glu-Arg-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Ala | N | NT | His | Leu | Val | Glu | Ala | Leu | Tyr | Leu | Johnson et al., 1999 | ||
beta-amyloid protein 42 | P05067 | 672-713 | peptide-Phe690+Phe-peptide | P | Lys | Leu | Val | Phe | Phe | Ala | Glu | Asp | Yan et al., 2006 | |||
angiotensin-1 | P01019 | 34-43 | Asp-Arg-Val-Tyr+Ile-His-Pro-Phe-His-Leu | N | Asp | Arg | Val | Tyr | Ile | His | Pro | Phe | Carson et al., 2002 | 24224 | ||
endothelin-1 | P05305 | 53-73 | peptide-Tyr65+Phe-peptide | P | Glu | Cys | Val | Tyr | Phe | Cys | His | Leu | Fahnoe et al., 2000 | 3731 |