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Peptidases

Inhibitor

Family Clan Small-molecule
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Structure for TMC-95 (XT01.001 inhibitor)

Summary Structure Literature

 

TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
subfamily T1A unassigned peptidases ( Saccharomyces cerevisiae)
proteasome complex bound to TMC-95A inhibitor 3.00 Å 1JD2 1JD2 1JD2 1JD2 1JD2 1JD2 Groll et al., 2001
proteasome subunit alpha 4 ( Saccharomyces cerevisiae)
proteasome complex bound to TMC-95A inhibitor 3.00 Å 1JD2 1JD2 1JD2 1JD2 1JD2 1JD2 Groll et al., 2001
subfamily T1A non-peptidase homologues ( Saccharomyces cerevisiae)
proteasome complex bound to TMC-95A inhibitor 3.00 Å 1JD2 1JD2 1JD2 1JD2 1JD2 1JD2 Groll et al., 2001
subfamily T1A unassigned peptidases ( Saccharomyces cerevisiae)
proteasome complex bound to TMC-95A inhibitor 3.00 Å 1JD2 1JD2 1JD2 1JD2 1JD2 1JD2 Groll et al., 2001
proteasome subunit alpha 1 ( Saccharomyces cerevisiae)
proteasome complex bound to TMC-95A inhibitor 3.00 Å 1JD2 1JD2 1JD2 1JD2 1JD2 1JD2 Groll et al., 2001
family T1 unassigned peptidases ( Saccharomyces cerevisiae)
proteasome complex bound to TMC-95A inhibitor 3.00 Å 1JD2 1JD2 1JD2 1JD2 1JD2 1JD2 Groll et al., 2001
proteasome subunit alpha 6 ( Saccharomyces cerevisiae)
proteasome complex bound to TMC-95A inhibitor 3.00 Å 1JD2 1JD2 1JD2 1JD2 1JD2 1JD2 Groll et al., 2001
proteasome subunit beta2c ( Saccharomyces cerevisiae)
proteasome complex bound to TMC-95A inhibitor 3.00 Å 1JD2 1JD2 1JD2 1JD2 1JD2 1JD2 Groll et al., 2001
subfamily T1A non-peptidase homologues ( Saccharomyces cerevisiae)
proteasome complex bound to TMC-95A inhibitor 3.00 Å 1JD2 1JD2 1JD2 1JD2 1JD2 1JD2 Groll et al., 2001
proteasome subunit beta 2 ( Saccharomyces cerevisiae)
proteasome complex bound to TMC-95A inhibitor 3.00 Å 1JD2 1JD2 1JD2 1JD2 1JD2 1JD2 Groll et al., 2001
proteasome subunit beta5c ( Saccharomyces cerevisiae)
proteasome complex bound to TMC-95A inhibitor 3.00 Å 1JD2 1JD2 1JD2 1JD2 1JD2 1JD2 Groll et al., 2001
20S proteasome component beta 6 ( Saccharomyces cerevisiae)
proteasome complex bound to TMC-95A inhibitor 3.00 Å 1JD2 1JD2 1JD2 1JD2 1JD2 1JD2 Groll et al., 2001
psmB4-2 g.p. (Dictyostelium discoideum) ( Saccharomyces cerevisiae)
proteasome complex bound to TMC-95A inhibitor 3.00 Å 1JD2 1JD2 1JD2 1JD2 1JD2 1JD2 Groll et al., 2001
proteasome subunit beta1c ( Saccharomyces cerevisiae)
proteasome complex bound to TMC-95A inhibitor 3.00 Å 1JD2 1JD2 1JD2 1JD2 1JD2 1JD2 Groll et al., 2001
subfamily T1A unassigned peptidases ( Saccharomyces cerevisiae)
20S proteasome; complex with TMC-95 based biphenyl-ether macrocycle 2.81 Å 2GPL 2GPL 2GPL 2GPL 2GPL 2GPL Groll et al., 2006
proteasome subunit alpha 4 ( Saccharomyces cerevisiae)
20S proteasome; complex with TMC-95 based biphenyl-ether macrocycle 2.81 Å 2GPL 2GPL 2GPL 2GPL 2GPL 2GPL Groll et al., 2006
subfamily T1A non-peptidase homologues ( Saccharomyces cerevisiae)
20S proteasome; complex with TMC-95 based biphenyl-ether macrocycle 2.81 Å 2GPL 2GPL 2GPL 2GPL 2GPL 2GPL Groll et al., 2006
subfamily T1A unassigned peptidases ( Saccharomyces cerevisiae)
20S proteasome; complex with TMC-95 based biphenyl-ether macrocycle 2.81 Å 2GPL 2GPL 2GPL 2GPL 2GPL 2GPL Groll et al., 2006
proteasome subunit alpha 1 ( Saccharomyces cerevisiae)
20S proteasome; complex with TMC-95 based biphenyl-ether macrocycle 2.81 Å 2GPL 2GPL 2GPL 2GPL 2GPL 2GPL Groll et al., 2006
family T1 unassigned peptidases ( Saccharomyces cerevisiae)
20S proteasome; complex with TMC-95 based biphenyl-ether macrocycle 2.81 Å 2GPL 2GPL 2GPL 2GPL 2GPL 2GPL Groll et al., 2006
proteasome subunit alpha 6 ( Saccharomyces cerevisiae)
20S proteasome; complex with TMC-95 based biphenyl-ether macrocycle 2.81 Å 2GPL 2GPL 2GPL 2GPL 2GPL 2GPL Groll et al., 2006
proteasome subunit beta2c ( Saccharomyces cerevisiae)
20S proteasome; complex with TMC-95 based biphenyl-ether macrocycle 2.81 Å 2GPL 2GPL 2GPL 2GPL 2GPL 2GPL Groll et al., 2006
subfamily T1A non-peptidase homologues ( Saccharomyces cerevisiae)
20S proteasome; complex with TMC-95 based biphenyl-ether macrocycle 2.81 Å 2GPL 2GPL 2GPL 2GPL 2GPL 2GPL Groll et al., 2006
proteasome subunit beta 2 ( Saccharomyces cerevisiae)
20S proteasome; complex with TMC-95 based biphenyl-ether macrocycle 2.81 Å 2GPL 2GPL 2GPL 2GPL 2GPL 2GPL Groll et al., 2006
proteasome subunit beta5c ( Saccharomyces cerevisiae)
20S proteasome; complex with TMC-95 based biphenyl-ether macrocycle 2.81 Å 2GPL 2GPL 2GPL 2GPL 2GPL 2GPL Groll et al., 2006
20S proteasome component beta 6 ( Saccharomyces cerevisiae)
20S proteasome; complex with TMC-95 based biphenyl-ether macrocycle 2.81 Å 2GPL 2GPL 2GPL 2GPL 2GPL 2GPL Groll et al., 2006
psmB4-2 g.p. (Dictyostelium discoideum) ( Saccharomyces cerevisiae)
20S proteasome; complex with TMC-95 based biphenyl-ether macrocycle 2.81 Å 2GPL 2GPL 2GPL 2GPL 2GPL 2GPL Groll et al., 2006
proteasome subunit beta1c ( Saccharomyces cerevisiae)
20S proteasome; complex with TMC-95 based biphenyl-ether macrocycle 2.81 Å 2GPL 2GPL 2GPL 2GPL 2GPL 2GPL Groll et al., 2006
subfamily T1A unassigned peptidases ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.80 Å 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ Desvergne et al., 2013
proteasome subunit alpha 4 ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.80 Å 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ Desvergne et al., 2013
subfamily T1A non-peptidase homologues ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.80 Å 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ Desvergne et al., 2013
subfamily T1A unassigned peptidases ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.80 Å 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ Desvergne et al., 2013
proteasome subunit alpha 1 ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.80 Å 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ Desvergne et al., 2013
family T1 unassigned peptidases ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.80 Å 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ Desvergne et al., 2013
proteasome subunit alpha 6 ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.80 Å 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ Desvergne et al., 2013
proteasome subunit beta2c ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.80 Å 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ Desvergne et al., 2013
subfamily T1A non-peptidase homologues ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.80 Å 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ Desvergne et al., 2013
proteasome subunit beta 2 ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.80 Å 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ Desvergne et al., 2013
proteasome subunit beta5c ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.80 Å 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ Desvergne et al., 2013
20S proteasome component beta 6 ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.80 Å 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ Desvergne et al., 2013
psmB4-2 g.p. (Dictyostelium discoideum) ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.80 Å 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ Desvergne et al., 2013
proteasome subunit beta1c ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.80 Å 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ 4JSQ Desvergne et al., 2013
subfamily T1A unassigned peptidases ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.90 Å 4JSU 4JSU 4JSU 4JSU 4JSU 4JSU Desvergne et al., 2013
proteasome subunit alpha 4 ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.90 Å 4JSU 4JSU 4JSU 4JSU 4JSU 4JSU Desvergne et al., 2013
subfamily T1A non-peptidase homologues ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.90 Å 4JSU 4JSU 4JSU 4JSU 4JSU 4JSU Desvergne et al., 2013
subfamily T1A unassigned peptidases ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.90 Å 4JSU 4JSU 4JSU 4JSU 4JSU 4JSU Desvergne et al., 2013
proteasome subunit alpha 1 ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.90 Å 4JSU 4JSU 4JSU 4JSU 4JSU 4JSU Desvergne et al., 2013
family T1 unassigned peptidases ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.90 Å 4JSU 4JSU 4JSU 4JSU 4JSU 4JSU Desvergne et al., 2013
proteasome subunit alpha 6 ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.90 Å 4JSU 4JSU 4JSU 4JSU 4JSU 4JSU Desvergne et al., 2013
proteasome subunit beta2c ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.90 Å 4JSU 4JSU 4JSU 4JSU 4JSU 4JSU Desvergne et al., 2013
subfamily T1A non-peptidase homologues ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.90 Å 4JSU 4JSU 4JSU 4JSU 4JSU 4JSU Desvergne et al., 2013
proteasome subunit beta 2 ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.90 Å 4JSU 4JSU 4JSU 4JSU 4JSU 4JSU Desvergne et al., 2013
proteasome subunit beta5c ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.90 Å 4JSU 4JSU 4JSU 4JSU 4JSU 4JSU Desvergne et al., 2013
20S proteasome component beta 6 ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.90 Å 4JSU 4JSU 4JSU 4JSU 4JSU 4JSU Desvergne et al., 2013
psmB4-2 g.p. (Dictyostelium discoideum) ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.90 Å 4JSU 4JSU 4JSU 4JSU 4JSU 4JSU Desvergne et al., 2013
proteasome subunit beta1c ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 2.90 Å 4JSU 4JSU 4JSU 4JSU 4JSU 4JSU Desvergne et al., 2013
subfamily T1A unassigned peptidases ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 3.10 Å 4JT0 4JT0 4JT0 4JT0 4JT0 4JT0 Desvergne et al., 2013
proteasome subunit alpha 4 ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 3.10 Å 4JT0 4JT0 4JT0 4JT0 4JT0 4JT0 Desvergne et al., 2013
subfamily T1A non-peptidase homologues ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 3.10 Å 4JT0 4JT0 4JT0 4JT0 4JT0 4JT0 Desvergne et al., 2013
subfamily T1A unassigned peptidases ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 3.10 Å 4JT0 4JT0 4JT0 4JT0 4JT0 4JT0 Desvergne et al., 2013
proteasome subunit alpha 1 ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 3.10 Å 4JT0 4JT0 4JT0 4JT0 4JT0 4JT0 Desvergne et al., 2013
family T1 unassigned peptidases ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 3.10 Å 4JT0 4JT0 4JT0 4JT0 4JT0 4JT0 Desvergne et al., 2013
proteasome subunit alpha 6 ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 3.10 Å 4JT0 4JT0 4JT0 4JT0 4JT0 4JT0 Desvergne et al., 2013
proteasome subunit beta2c ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 3.10 Å 4JT0 4JT0 4JT0 4JT0 4JT0 4JT0 Desvergne et al., 2013
subfamily T1A non-peptidase homologues ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 3.10 Å 4JT0 4JT0 4JT0 4JT0 4JT0 4JT0 Desvergne et al., 2013
proteasome subunit beta 2 ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 3.10 Å 4JT0 4JT0 4JT0 4JT0 4JT0 4JT0 Desvergne et al., 2013
proteasome subunit beta5c ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 3.10 Å 4JT0 4JT0 4JT0 4JT0 4JT0 4JT0 Desvergne et al., 2013
20S proteasome component beta 6 ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 3.10 Å 4JT0 4JT0 4JT0 4JT0 4JT0 4JT0 Desvergne et al., 2013
psmB4-2 g.p. (Dictyostelium discoideum) ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 3.10 Å 4JT0 4JT0 4JT0 4JT0 4JT0 4JT0 Desvergne et al., 2013
proteasome subunit beta1c ( Saccharomyces cerevisiae)
20S proteasome; complex with dimerized linear mimetic of TMC-95A 3.10 Å 4JT0 4JT0 4JT0 4JT0 4JT0 4JT0 Desvergne et al., 2013

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