Small-molecule inhibitor: PCMB
Name
- Common name
- PCMB
- Other names
- p-chloromercuribenzoate
Inhibition
- Peptidases inhibited
- Inhibits cysteine peptidases, but also some serine peptidases and metallopeptidases that have thiol groups that affect activity. The latter peptidases include furin, thimet oligopeptidase (Barrett & Brown, 1990) and dipeptidyl-peptidase III (Abramic et al., 2004).
- Mechanism
- Reversible inhibition, primarily mediated by interaction of the mercury atom with the sulfur of a thiol group. However, inhibition is non-specific, and hydrophobic interactions of the phenyl ring may contribute.
Chemistry
- CID at PubChem
- 1730
- ChEBI
- 28420
- Structure
![[PCMB (C01.001 inhibitor) structure ]](/merops/smi/structures/pcmb.gif)
- Chemical/biochemical name
- 4-chloromercuribenzoic acid
- Formula weight
- 357
- Related inhibitors
- p-hydroxymercuribenzoate (HMBA); p-hydroxymercuribenzenesulfonate (HMBSA)
General
- Comment
- Because aqueous solubility of p-chloromercuribenzoic acid is low, it is commonly dissolved in dilute NaOH, which is likely to convert it to p-hydroxymercuribenzoate, so it may be unclear from published articles what the final form of the inhibitor was. Mercuribenzenesulfonate is an analogue sometimes used for its greater solubility.
