Small-molecule inhibitor: BMS-299897
Name
- Common name
- BMS-299897
Inhibition
- Peptidases inhibited
- Inhibits Alzheimer"s disease-related gamma-secretase activity such as that of presenilin 1 (Anderson et al. 2005).
- Pharmaceutical relevance
- Shows therapeutic activity in a model of Alzheimer"s disease (Anderson et al. 2005).
Chemistry
- CID at PubChem
- 11249248
- Structure
- Chemical/biochemical name
- 4-[2-((1R)-1-[[(4-chlorophenyl)sulfonyl]-2,5-difluoroanilino]ethyl)-5-fluorophenyl]butanoic acid
- Formula weight
- 512
![[BMS-299897 (A22.001 inhibitor) structure ]](http://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&cid=11249248)
Properties
- Synthesis
- Malmquist et al. 2010
