Small-molecule inhibitor: odanacatib
Name
- Common name
- odanacatib
- Other names
- L-1037536; MK-0822; MK-822
Inhibition
- Peptidases inhibited
- Odanacatib is a potent, selective, and neutral inhibitor of cathepsin K. Inhibition is reversible, with low nM Ki (Gauthier et al., 2008).
- Pharmaceutical relevance
- This inhibitor is in clinical trials for inhibition of bone resorption.
Chemistry
- CID at PubChem
- 10152654
- Structure
- Formula weight
- 526
- Related inhibitors
- L-873724, relacatib, balicatib.
![[odanacatib (C01.036 inhibitor) structure ]](http://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&cid=10152654)
Properties
- Synthesis
- Gauthier et al., 2008
