Small-molecule inhibitor: TNP-470

Summary Structure Literature

Name

Common name: TNP-470
Other names: AGM-1470

Inhibition

Peptidases inhibited: methionyl aminopeptidase 2
Mechanism: See fumagillin.

Chemistry

CID at PubChem: 14942883
Structure
Chemical/biochemical name: [(3R,4S,5S,6R)-5-methoxy-4-[(2S,3S)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] N-(2-chloroacetyl)carbamate
Related inhibitors: TNP-470 is an epoxide-containing natural product related to fumagillin and ovalicin as is described more fully under fumagillin.