Small-molecule inhibitor: SNJ-1945
Name
- Common name
- SNJ-1945
Inhibition
- Peptidases inhibited
- Inhibits calpain-1 and calpain-2 with IC50 values in the 86-190 nM range (Cuerrier et al., 2006).
- Mechanism
- SNJ-1945 is a reversible alpha-ketoamide inhibitor. The structure of the proteolytic core of rat calpain-1 in complex with SNJ-1945 has been determined (Cuerrier et al., 2006).
- Pharmaceutical relevance
- SNJ-1945 is orally bioavailable, amphipathic ketoamide, and has been investigated for control of calpain-mediated proteolysis in retina and heart.
Chemistry
- CID at PubChem
- 6857712
- Structure
- Chemical/biochemical name
- ((1S)-1((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl )-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester
- Formula weight
- 492
![[SNJ-1945 (C02.001, C02.002 inhibitor) structure ]](http://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?t=l&cid=6857712)
