Small-molecule inhibitor: PL-100

Summary Structure Literature

Name

Common name: PL-100

Inhibition

History: A series of lysine sulfonamide analogues bearing Nepsilon-acyl aromatic amino acids was found to include compounds with high potency against wild-type and multiple-protease inhibitor-resistant HIV viruses (Stranix et al., 2006). The molecular mechanism of interaction with wild type and inhibitor-resistant forms of HIV-1 retropepsin has been studied (Asahchop et al., 2013).
Peptidases inhibited: HIV-1 retropepsin

Chemistry

CID at PubChem: 513956
Structure