Small-molecule inhibitor: probestin
Name
- Common name
- probestin
Inhibition
- History
- Probestin is a natural product of Streptomyces azureus MH663-2F6 discovered by Aoyagi et al. (1990).
- Peptidases inhibited
- Inhibits aminopeptidase N (Ki = 19 nM: Aoyagi et al., 1990), and also aminopeptidase A and <#aminopeptidase W#M9A.007#> at micromolar concentrations (Tieku & Hooper, 1992). Also inhibits human dipeptidylaminopeptidase III (Abramic et al., 2000) and insect aminopeptidase N (Hua et al., 1998).
- Mechanism
- Inhibition is reversible.
Chemistry
- CID at PubChem
- 130013
- Structure
![[probestin (M01.001 inhibitor) structure ]](/merops/smi/structures/probestin.gif)
- Chemical/biochemical name
- 1-(1-(N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)leucyl)prolyl)proline
- Formula weight
- 503
