Small-molecule inhibitor: leuhistin
Name
- Common name
- leuhistin
Inhibition
- History
- Leuhistin, a natural product of Bacillus laterosporus BMI156-14F1, was discovered by Aoyagi and co-workers (Yoshida et al., 1991).
- Peptidases inhibited
- Regarded as a specific inhibitor of aminopeptidase N (Ki = 230 nM); weakly inhibits aminopeptidase A and aminopeptidase B (Aoyagi et al., 1991). Also inhibits cytosol alanyl aminopeptidase (Yamamoto et al., 2000).
- Mechanism
- Inhibition is reversible, and may be competitive (Aoyagi et al., 1991) or not (Masler, 2002).
Chemistry
- CID at PubChem
- 131057
- Structure
![[leuhistin (M01.001 inhibitor) structure ]](/merops/smi/structures/leuhistin.gif)
- Chemical/biochemical name
- (2R,3S)-3-amino-2-hydroxy-2-(3H-imidazol-4-ylmethyl)-5-methyl-hexanoic acid
- Formula weight
- 241
