Small-molecule inhibitor: benazeprilat
Name
- Common name
- benazeprilat
- Other names
- CGS 14824; benazepril (prodrug form); Lotensin
Inhibition
- History
- Benazeprilat (under the name CGS 14824) was developed in the mid-1980"s (Waeber et al., 1987), and accounts of its clinical use as an inhibitor of angiotensin-converting enzyme compound peptidase appeared in the literature under the name of benazepril in 1988 (e.g. Van Hecken et al., 1988).
- Peptidases inhibited
- Angiotensin-converting enzyme compound peptidase.
- Mechanism
- Inhibition is reversible.
- Pharmaceutical relevance
- Benazepril has been widely used as a drug for the control of blood pressure.
- DrugBank
- DB00542
Chemistry
- CID at PubChem
- 5463984
- Structure
![[benazeprilat (XM02.001 inhibitor) structure ]](/merops/smi/structures/benazepril.gif)
- Chemical/biochemical name
- (2S)-2-[[(4S)-2-(carboxymethyl)-3-oxo-2-azabicyclo[5.4.0]undeca-7,9,11-trien-4-yl]amino]-4-phenyl-butanoic acid
- Formula weight
- 396
Properties
- Stability
- <%Gana %etal (2002)[20060824A190]%>
General
- Comment
- Benazepril is an ester, pro-form of the active metabolite, benazeprilat.
