Small-molecule inhibitor: temocapril

Summary Literature

Name

Common name: temocapril
Other names: CS-622; RS-5139; temocaprilat

Inhibition

History: Temocapril and its prodrug form were described (as CS-622) by Oizumi et al. (1988).
Peptidases inhibited: The active metabolite inhibits angiotensin-converting enzyme compound peptidase (ACE).
Mechanism: Reversible.
Pharmaceutical relevance: Temocapril has been used clinically as an ACE inhibitor.

Chemistry

CID at PubChem: 71323
Structure
Chemical/biochemical name: 2-[(2S)-6-[[(1S)-1-ethoxycarbonyl-3-phenyl-propyl]amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid
Formula weight: 477
Related inhibitors: The terms RS-5139 and temocaprilat refer to the active metabolite.