Small-molecule inhibitor: faldaprevir

Name

History: The discovery of BI 201335 was described by Llinas-Brunet et al. (2010).
Peptidases inhibited: Inhibits hepacivirin from hepatitis C virus of genotype 1.
Pharmaceutical relevance: This compound has been shown to have potent clinical activity against hepatitis C (White et al. 2010). Mutations in hepacivirin that cause resistance to macrocyclic and covalent inhibitors do not confer resistance to BI 201335 (Lagace et al. 2012). .

CID at PubChem: 42601552
Structure
Chemical/biochemical name: (1R,2S)-1-[[(2S,4R)-4-[8-bromo-7-methoxy-2-[2-(2-methylpropanoylamino)-1,3-thiazol-4-yl]quinolin-4-yl]oxy-1-[(2S)-2-(cyclopentyloxycarbonylamino)-3,3-dimethylbutanoyl]pyrrolidine-2-carbonyl]amino]-2-ethenylcyclopropane-1-carboxylic acid
Formula weight: 870