Small-molecule inhibitor: danoprevir

Name

Peptidases inhibited: Inhibits hepacivirin.
Mechanism: A study of the mechanism of action of danoprevir provided results consistent with the formation of an initial collision complex between the enzyme and the inhibitor that isomerizes to a highly stable complex that dissociates only very slowly, so that the effective K_i is sub-nanomolar (Rajagopalan et al., 2009).
Pharmaceutical relevance: Danoprevir shows promise for the treatment of hepatitis C (Forestier et al., 2011).