Small-molecule inhibitor: arylomycin A2

Summary Structure Literature

Name

Common name: arylomycin A2

Inhibition

History: Arylomycins were discovered as lipo-hexapeptide antibiotics produced by Streptomyces sp. Tu 6075 (Schimana et al., 2002).
Peptidases inhibited: Inhibits bacterial signal peptidase I with nanomolar potency (Kulanthaivel et al., 2004).
Mechanism: Reversible, competitive inhibitors, binding near the catalytic site (Luo et al., 2009).

Chemistry

CID at PubChem: 5287707
Structure
Chemical/biochemical name: Arylomycin A2 can be described as a lipohexapeptide (d-MeSer-d-Ala-Gly-l-MeHpg-l-Ala-l-Tyr) with a 12-carbon atom branched fatty acid (iso-C12) attached via an amide bond to the N-terminus (Li et al., 2008).
Formula weight: 685
Related inhibitors: Arylomycin A2 is one of a family of such compounds.

Properties

Synthesis: Dufour et al. (2008)