Sequence features for peptidase M10.023: membrane-type matrix metallopeptidase-5

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Pharma

 

MERNUM Species Sequence length Peptidase unit Active site residues Metal ligands Source
MER0005069 Mus musculus 618 125-315 E256 H255, H259, H265 UNIPROT:Q9R0S2
MER0005638 Homo sapiens 645 152-342 E283 H282, H286, H292 UNIPROT:Q9Y5R2
MER0015158 Rattus norvegicus 618 125-315 E256 H255, H259, H265 UNIPROT:Q99PW6
MER0029693 Danio rerio 369 1-65 E10 H9, H13, H19 GENBANK:CAE51058
MER0078069 Xenopus tropicalis 592 109-274 E230 H229, H233, H239 GENBANK:XP_002942325
MER0090971 Tetraodon nigroviridis 578 68-247 T196 T196, T196, P199 UNIPROT:Q4TAX5
MER0098657 Equus caballus 666 173-363 E304 H303, H307, H313 GENBANK:XP_001499275
MER0102126 Myotis lucifugus 573 80-255 E211 H210, H214, H220 GENBANK:XP_006089512
MER0103175 Loxodonta africana 573 90-266 E211 H210, H214, H220 GENBANK:XP_003411565
MER0103491 Cavia porcellus 715 232-408 E353 H352, H356, H362 GENBANK:XP_003467783
MER0110370 Oryctolagus cuniculus 574 91-267 E212 H211, H215, H221 GENBANK:XP_002710873
MER0113570 Bos taurus 596 103-293 E234 H233, H237, H243 GENBANK:XP_616761
MER0117639 Papio anubis 598 105-295 E236 H235, H239, H245 GENBANK:ABY64668
MER0126798 Callithrix jacchus 595 112-288 E233 H232, H236, H242 GENBANK:XP_002747296
MER0141762 Rhinolophus ferrumequinum 547 54-244 E185 H184, H188, H194 GENBANK:ACC68950
MER0141781 Callicebus moloch 595 102-292 E233 H232, H236, H242 GENBANK:ACA64881
MER0167407 Strongylocentrotus purpuratus 522 139-384 Q253 H252, H256, H262 GENBANK:XP_790682
MER0190944 Nomascus leucogenys 591 108-284 E229 H228, H232, H238 GENBANK:XP_004093216
MER0219130 Ursus maritimus 573 80-255 E211 H210, H214, H220 GENBANK:XP_008696386
MER0225336 Anolis carolinensis 604 121-297 E242 H241, H245, H251 GENBANK:XP_003220578
MER0262916 Sorex araneus 532 39-214 E170 H169, H173, H179 GENBANK:XP_004612597
MER0268696 Ailuropoda melanoleuca 630 147-323 E268 H267, H271, H277 GENBANK:XP_002916480
MER0268951 Macaca fascicularis 564 81-257 E202 H201, H205, H211 GENBANK:EHH65396
MER0279066 Cricetulus griseus 552 68-226 E182 H181, H185, H191 GENBANK:EGW02769
MER0290992 Cricetulus griseus 611 128-304 E249 H248, H252, H258 GENBANK:XP_003501204
MER0290993 Meleagris gallopavo 557 99-275 E220 H219, H223, H229 GENBANK:XP_003211965
MER0291000 Pongo abelii 569 86-262 E207 H206, H210, H216 GENBANK:XP_003780705
MER0291060 Oreochromis niloticus 624 132-308 E253 H252, H256, H262 GENBANK:XP_003456286
MER0329793 Gorilla gorilla 595 112-288 E233 H232, H236, H242 GENBANK:XP_004062101
MER0329796 Pteropus alecto 573 90-266 E211 H210, H214, H220 GENBANK:ELK04130
MER0329813 Ovis aries 575 90-266 E211 H210, H214, H220 GENBANK:XP_004014867
MER0329857 Saimiri boliviensis 596 113-289 E234 H233, H237, H243 GENBANK:XP_003932167
MER0329874 Felis catus 631 148-324 E269 H268, H272, H278 GENBANK:XP_003983651
MER0341968 Pan paniscus 596 113-289 E234 H233, H237, H243 GENBANK:XP_003831888
MER0341969 Otolemur garnettii 617 134-310 E255 H254, H258, H264 GENBANK:XP_003788293
MER0341972 Sarcophilus harrisii 656 174-350 E295 H294, H298, H304 GENBANK:XP_003757006
MER0342077 Sus scrofa 635 248-351 missing missing, missing, missing GENBANK:XP_003360009
MER0375441 Tauraco erythrolophus 578 85-260 E216 H215, H219, H225 GENBANK:XP_009986483
MER0452300 Tyto alba 548 55-230 E186 H185, H189, H195 GENBANK:XP_009968667
MER0465311 Tinamus guttatus 548 55-230 E186 H185, H189, H195 GENBANK:XP_010212276
MER0485189 Trichechus manatus 531 39-407 E170 H169, H173, H179 GENBANK:XP_004370463
MER0514023 Struthio camelus 638 145-320 E276 H275, H279, H285 GENBANK:XP_009677584
MER0551104 Serinus canaria 548 55-230 E186 H185, H189, H195 GENBANK:XP_009097017
MER0571184 Rhinopithecus roxellana 602 109-284 E240 H239, H243, H249 GENBANK:XP_010384831
MER0627989 Picoides pubescens 548 55-230 E186 H185, H189, H195 GENBANK:XP_009904013
MER0632490 Phaethon lepturus 548 55-230 E186 H185, H189, H195 GENBANK:XP_010281032
MER0633252 Pelecanus crispus 548 55-230 E186 H185, H189, H195 GENBANK:XP_009485076
MER0633438 Opisthocomus hoazin 548 55-230 E186 H185, H189, H195 GENBANK:XP_009936911
MER0636736 Nipponia nippon 548 55-230 E186 H185, H189, H195 GENBANK:XP_009471535
MER0637310 Nestor notabilis 548 55-230 E186 H185, H189, H195 GENBANK:XP_010021597
MER0640301 Nannospalax galili 573 80-255 E211 H210, H214, H220 GENBANK:XP_008838961
MER0643706 Mesitornis unicolor 548 55-230 E186 H185, H189, H195 GENBANK:XP_010192396
MER0644882 Mandrillus leucophaeus 597 104-279 E235 H234, H238, H244 GENBANK:XP_011827793
MER0647085 Manacus vitellinus 548 55-230 E186 H185, H189, H195 GENBANK:XP_008932760
MER0652459 Haliaeetus leucocephalus 548 55-230 E186 H185, H189, H195 GENBANK:XP_010582340
MER0652628 Haliaeetus albicilla 548 55-230 E186 H185, H189, H195 GENBANK:XP_009910869
MER0654188 Gavia stellata 548 55-230 E186 H185, H189, H195 GENBANK:XP_009810839
MER0654984 Fulmarus glacialis 548 55-230 E186 H185, H189, H195 GENBANK:XP_009580174
MER0655791 Fukomys damarensis 612 119-294 E250 H249, H253, H259 GENBANK:XP_010638378
MER0664017 Egretta garzetta 548 55-230 E186 H185, H189, H195 GENBANK:XP_009647588
MER0665584 Cuculus canorus 621 128-303 E259 H258, H262, H268 GENBANK:XP_009563704
MER0667211 Corvus cornix 548 55-230 E186 H185, H189, H195 GENBANK:XP_010389050
MER0669312 Colobus angolensis 598 105-280 E236 H235, H239, H245 GENBANK:XP_011784555
MER0672211 Charadrius vociferus 567 74-249 E205 H204, H208, H214 GENBANK:XP_009890406
MER0673128 Chaetura pelagica 614 121-296 E252 H251, H255, H261 GENBANK:XP_009997668
MER0675683 Cariama cristata 548 55-230 E186 H185, H189, H195 GENBANK:XP_009695756
MER0680528 Bison bison 562 124-299 E255 H254, H258, H264 GENBANK:XP_010853316
MER0686515 Aquila chrysaetos 597 104-283 E235 H234, H238, H244 GENBANK:XP_011589736
MER0687143 Aptenodytes forsteri 548 55-230 E186 H185, H189, H195 GENBANK:XP_009282287
MER0689780 Acanthisitta chloris 550 55-232 E188 H187, H191, H197 GENBANK:XP_009069612
MER0824922 Oncorhynchus mykiss 278 48-194 E149 H148, H152, H158 UNIPROT:A0A060X555
MER0825068 Pygoscelis adeliae 571 88-254 E209 H208, H212, H218 UNIPROT:A0A093NGX3
MER0825227 Camelus ferus 838 312-478 E433 H432, H436, H442 UNIPROT:S9WQ54
MER0825256 Podiceps cristatus 571 88-254 E209 H208, H212, H218 UNIPROT:A0A094L854
MER0825447 Monodelphis domestica 563 82-248 E203 H202, H206, H212 UNIPROT:F6SPF3
MER0825592 Cathartes aura 373 2-56 E11 H10, H14, H20 UNIPROT:A0A091LN07
MER0825859 Ophiophagus hannah 614 131-297 E252 H251, H255, H261 UNIPROT:V8P548
MER0826678 Petromyzon marinus 582 81-248 E202, H201, H205, H211, UNIPROT:S4R9S5