Literature for peptidase M79.002: RCE1 peptidase (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates Inhibitors Pharma

(Topics flags: A Assay, P Specificity, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

  1. Mohammed,I., Hampton,S.E., Ashall,L., Hildebrandt,E.R., Kutlik,R.A., Manandhar,S.P., Floyd,B.J., Smith,H.E., Dozier,J.K., Distefano,M.D., Schmidt,W.K. & Dore,T.M.
    8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells.
    Bioorg Med Chem (2016) 24, 160-178. PubMed  Europe PubMed DOI  I
  2. 2014
  3. Jaworski,J., Govender,U., McFarlane,C., de la Vega,M., Greene,M.K., Rawlings,N.D., Johnston,J.A., Scott,C.J. & Burrows,J.F.
    A novel RCE1 isoform is required for H-Ras plasma membrane localization and is regulated by USP17.
    Biochem J (2014) 457, 289-300. PubMed  Europe PubMed DOI
  4. 2012
  5. Dore,T.M. & Schmidt,W.K.
    Isoprenylated protein peptidase Rce1p.
    In Handbook of Proteolytic Enzymes, 3 edn (Rawlings,N.D. & Salvesen,G.S. eds), p.1720-1726, Elsevier, Amsterdam (2012) DOI
  6. 2011
  7. Christiansen,J.R., Kolandaivelu,S., Bergo,M.O. & Ramamurthy,V.
    RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments.
    Proc Natl Acad Sci U S A (2011) 108, 8862-8866. PubMed  Europe PubMed DOI  K
  8. Schmidt,W.K. & Dore,T.M.
    The Ras converting enzyme (Rce1p). Orthologs, enzymology, and inhibitors.
    Enzymes (2011) 30, 231-258. DOI
  9. 2010
  10. Dechert,A.M., Macnamara,J.P., Breevoort,S.R., Hildebrandt,E.R., Hembree,N.W., Rea,A.C., McLain,D.E., Porter,S.B., Schmidt,W.K. & Dore,T.M.
    Modulation of the inhibitor properties of dipeptidyl (acyloxy)methyl ketones toward the CaaX proteases.
    Bioorg Med Chem (2010) 18, 6230-6237. PubMed  Europe PubMed DOI  I
  11. 2008
  12. Bracha-Drori,K., Shichrur,K., Lubetzky,T.C. & Yalovsky,S.
    Functional analysis of Arabidopsis postprenylation CaaX processing enzymes and their function in subcellular protein targeting.
    Plant Physiol (2008) 148, 119-131. PubMed  Europe PubMed DOI  PMC  EPMC
  13. 2007
  14. Manandhar,S.P., Hildebrandt,E.R. & Schmidt,W.K.
    Small-molecule inhibitors of the Rce1p CaaX protease.
    J Biomol Screen (2007) 12, 983-993. PubMed  Europe PubMed DOI  PMC  EPMC  I
  15. 2006
  16. Fueller,F., Bergo,M.O., Young,S.G., Aktories,K. & Schmidt,G.
    Endoproteolytic processing of RhoA by Rce1 is required for the cleavage of RhoA by Yersinia enterocolitica outer protein T.
    Infect Immun (2006) 74, 1712-1717. PubMed  Europe PubMed DOI  PMC  EPMC
  17. 2005
  18. Winter-Vann,A.M. & Casey,P.J.
    Post-prenylation-processing enzymes as new targets in oncogenesis.
    Nat Rev Cancer (2005) 5, 405-412. PubMed  Europe PubMed DOI
  19. 2004
  20. Bergo,M.O., Lieu,H.D., Gavino,B.J., Ambroziak,P., Otto,J.C., Casey,P.J., Walker,Q.M. & Young,S.G.
    On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy.
    J Biol Chem (2004) 279, 4729-4736. PubMed  Europe PubMed DOI  K
  21. Casey,P.J. & Rando,R.R.
    Isoprenylated protein peptidase Rce1.
    In Handbook of Proteolytic Enzymes, 2 edn (Barrett,A.J., Rawlings,N.D. & Woessner,J.F. eds), p.2123-2127, Elsevier, London (2004)  V
  22. 2003
  23. Cadinanos,J., Varela,I., Mandel,D.A., Schmidt,W.K., Diaz-Perales,A., Lopez-Otin,C. & Freije,J.M.
    AtFACE-2, a functional prenylated protein protease from Arabidopsis thaliana related to mammalian Ras-converting enzymes.
    J Biol Chem (2003) 278, 42091-42097. PubMed  Europe PubMed DOI
  24. Hollander,I.J., Frommer,E., Aulabaugh,A. & Mallon,R.
    Human Ras converting enzyme endoproteolytic specificity at the P2' and P3' positions of K-Ras-derived peptides.
    Biochim Biophys Acta (2003) 1649, 24-29. PubMed  Europe PubMed DOI  P
  25. Maske,C.P., Hollinshead,M.S., Higbee,N.C., Bergo,M.O., Young,S.G. & Vaux,D.J.
    A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation.
    J Cell Biol (2003) 162, 1223-1232. PubMed  Europe PubMed DOI  PMC  EPMC
  26. 2002
  27. Bergo,M.O., Ambroziak,P., Gregory,C., George,A., Otto,J.C., Kim,E., Nagase,H., Casey,P.J., Balmain,A. & Young,S.G.
    Absence of the CAAX endoprotease Rce1: Effects on cell growth and transformation.
    Mol Cell Biol (2002) 22, 171-181. PubMed  Europe PubMed DOI  PMC  EPMC  K
  28. 2001
  29. Pei,J. & Grishin,N.V.
    Type II CAAX prenyl endopeptidases belong to a novel superfamily of putative membrane-bound metalloproteases.
    Trends Biochem Sci (2001) 26, 275-277. PubMed  Europe PubMed DOI
  30. 2000
  31. Hollander,I., Frommer,E. & Mallon,R.
    Human Ras-converting enzyme (hRCE1) endoproteolytic activity on K-Ras-derived peptides.
    Anal Biochem (2000) 286, 129-137. PubMed  Europe PubMed DOI  A
  32. Young,S.G., Ambroziak,P., Kim,E. & Clarke,S.
    Postisoprenylation protein processing: CXXX (CaaX) endoproteases and isoprenylcysteine carboxyl methyltransferase.
    In The enzymes, Vol. 21 (Tamanoi,F. & Sigman,D.S. eds), p.155-213, Academic Press, San Diego, Calif., (2000)
  33. 1999
  34. Chen,Y.
    Selective inhibition of ras-transformed cell growth by a novel fatty acid-based chloromethyl ketone designed to target Ras endoprotease.
    Ann N Y Acad Sci (1999) 886, 103-108. PubMed  Europe PubMed
  35. Freije,J.M., Blay,P., Pendas,A.M., Cadinanos,J., Crespo,P. & Lopez-Otin,C.
    Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins.
    Genomics (1999) 58, 270-280. PubMed  Europe PubMed DOI
  36. Kim,E., Ambroziak,P., Otto,J.C., Taylor,B., Ashby,M., Shannon,K., Casey,P.J. & Young,S.G.
    Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells.
    J Biol Chem (1999) 274, 8383-8390. PubMed  Europe PubMed DOI  K
  37. Otto,J.C., Kim,E., Young,S.G. & Casey,P.J.
    Cloning and characterization of a mammalian prenyl protein-specific protease.
    J Biol Chem (1999) 274, 8379-8382. PubMed  Europe PubMed DOI
  38. 1998
  39. Chen,Y.
    Inhibition of K-ras-transformed rodent and human cancer cell growth via induction of apoptosis by irreversible inhibitors of Ras endoprotease.
    Cancer Lett (1998) 131, 191-200. PubMed  Europe PubMed DOI  I
  40. Jang,G.F. & Gelb,M.H.
    Substrate specificity of mammalian prenyl protein-specific endoprotease activity.
    Biochemistry (1998) 37, 4473-4481. PubMed  Europe PubMed DOI
  41. 1997
  42. Nishii,W., Muramatsu,T., Kuchino,Y., Yokoyama,S. & Takahashi,K.
    Partial purification and characterization of a CAAX-motif-specific protease from bovine brain using a novel fluorometric assay.
    J Biochem (1997) 122, 402-408. PubMed  Europe PubMed  A
  43. 1996
  44. Chen,Y., Ma,Y.T. & Rando,R.R.
    Solubilization, partial purification, and affinity labeling of the membrane-bound isoprenylated protein endoprotease.
    Biochemistry (1996) 35, 3227-3237. PubMed  Europe PubMed DOI
  45. Hitz,A.M. & Georgopapadakou,N.H.
    Mammalian microsomal and soluble Ras-processing peptidase activities are distinct.
    FEBS Lett (1996) 391, 310-312. PubMed  Europe PubMed DOI
  46. 1995
  47. Ashby,M.N. & Rine,J.
    Ras and a-factor converting enzyme.
    Methods Enzymol (1995) 250, 235-251. PubMed  Europe PubMed DOI  V
  48. Gilbert,B.A., Ma,Y.T. & Rando,R.R.
    Inhibitors of prenylated protein endoprotease.
    Methods Enzymol (1995) 250, 206-215. PubMed  Europe PubMed DOI  V  I
  49. Hall,C.C., Watkins,J.D., Ferguson,S.B., Foley,L.H. & Georgopapadakou,N.H.
    Inhibitors of farnesyltransferase and RAS processing peptidase.
    Biochem Biophys Res Commun (1995) 217, 728-732. PubMed  Europe PubMed DOI  I
  50. 1994
  51. Rando,R.R. & Ma,Y.T.
    Isoprenylated protein endopeptidase.
    Methods Enzymol (1994) 244, 632-639. PubMed  Europe PubMed DOI  V
  52. 1993
  53. Ma,Y.T., Gilbert,B.A. & Rando,R.R.
    Inhibitors of the isoprenylated protein endoprotease.
    Biochemistry (1993) 32, 2386-2393. PubMed  Europe PubMed  I
  54. 1992
  55. Ma,Y.T. & Rando,R.R.
    A microsomal endoprotease that specifically cleaves isoprenylated peptides.
    Proc Natl Acad Sci U S A (1992) 89, 6275-6279. PubMed  Europe PubMed DOI  PMC  EPMC