Literature for peptidase S08.039: PCSK9 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

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    2020
  1. Petrilli,W.L., Adam,G.C., Erdmann,R.S., Abeywickrema,P., Agnani,V., Ai,X., Baysarowich,J., Byrne,N., Caldwell,J.P., Chang,W., DiNunzio,E., Feng,Z., Ford,R., Ha,S., Huang,Y., Hubbard,B., Johnston,J.M., Kavana,M., Lisnock,J.M., Liang,R., Lu,J., Lu,Z., Meng,J., Orth,P., Palyha,O., Parthasarathy,G., Salowe,S.P., Sharma,S., Shipman,J., Soisson,S.M., Strack,A.M., Youm,H., Zhao,K., Zink,D.L., Zokian,H., Addona,G.H., Akinsanya,K., Tata,J.R., Xiong,Y. and Imbriglio,J.E.
    From screening to targeted degradation: strategies for the discovery and optimization of small molecule ligands for PCSK9
    Cell Chem Biol27, 32-40. PubMed  Europe PubMed DOI  S  I
  2. 2014
  3. Zhang,Y., Eigenbrot,C., Zhou,L., Shia,S., Li,W., Quan,C., Tom,J., Moran,P., Di Lello,P., Skelton,N.J., Kong-Beltran,M., Peterson,A. and Kirchhofer,D.
    Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor
    J Biol Chem289, 942-955. PubMed  Europe PubMed DOI  S  I
  4. 2011
  5. Surdo,P.L., Bottomley,M.J., Calzetta,A., Settembre,E.C., Cirillo,A., Pandit,S., Ni,Y.G., Hubbard,B., Sitlani,A. and Carfi,A.
    Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH
    EMBO Rep12, 1300-1305. PubMed  Europe PubMed DOI  S
  6. 2008
  7. Kwon,H.J., Lagace,T.A., McNutt,M.C., Horton,J.D. and Deisenhofer,J.
    Molecular basis for LDL receptor recognition by PCSK9
    Proc Natl Acad Sci U S A105, 1820-1825. PubMed  Europe PubMed DOI  S
  8. 2007
  9. Hampton,E.N., Knuth,M.W., Li,J., Harris,J.L., Lesley,S.A. and Spraggon,G.
    The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain
    Proc Natl Acad Sci U S A104, 14604-14609. PubMed  Europe PubMed DOI  S
  10. Piper,D.E., Jackson,S., Liu,Q., Romanow,W.G., Shetterly,S., Thibault,S.T., Shan,B. and Walker,N.P.
    The crystal structure of PCSK9: a regulator of plasma LDL-cholesterol
    Structure15, 545-552. PubMed  Europe PubMed DOI  S