Summary for peptidase A22.006: signal peptide peptidase-like protein 2C

Summary Alignment Tree Sequences Sequence features Distribution Literature


MEROPS Namesignal peptide peptidase-like protein 2C
Other namesimpas 5 peptidase, IMP5, intramembrane protease 5, KIAA1532-like protein, PSH2, presenilin homologue-2, SPPL2C g.p. (Homo sapiens)
Name and HistorySignal peptide peptidase-like 2C is a homologue of intramembrane-cleaving GXGD aspartic endopeptidases. Unlike other members of the family, SPPL2C has not been characterized, and the lack of introns, low level of expression and high degree of polymorphism in the human gene has led to the suggestion that it is a pseudogene (Ponting et al., 2002).
Domain architecture
MEROPS Classification
Classification Clan AD >> Subclan (none) >> Family A22 >> Subfamily B >> A22.006
Holotypesignal peptide peptidase-like protein 2C (Homo sapiens), Uniprot accession Q8IUH8 (peptidase unit: 332-523), MERNUM MER0019712
History Identifier created: MEROPS 6.0 (30 August 2002)
Catalytic typeAspartic
NC-IUBMBNot yet included in IUBMB recommendations.
Activity statushuman: putative (Grigorenko et al., 2002)
mouse: putative
Other databases TREEFAM
Human genetics
Gene symbol Locus Megabases Ensembl Entrez gene Gene Cards OMIM
SPPL2C 17q21.31 ENSG00000168474 162540 608284