Summary for peptidase A08.001: signal peptidase II

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors


MEROPS Namesignal peptidase II
Other namesleader peptidase II, lspA g.p. (Escherichia coli), premurein leader peptidase, prolipoprotein-leader peptidase, prolipoprotein signal peptidase
Domain architecture
MEROPS Classification
Classification Clan AC >> Subclan (none) >> Family A8 >> Subfamily (none) >> A08.001
Holotypesignal peptidase II (Escherichia coli), Uniprot accession P00804 (peptidase unit: 1-164), MERNUM MER0001313
History Identifier created: Handbook of Proteolytic Enzymes (1998) Academic Press, London.
Catalytic typeAspartic
PeplistIncluded in the Peplist with identifier PL00040
NC-IUBMBSubclass 3.4 (Peptidases) >> Sub-subclass 3.4.23 (Aspartic endopeptidases) >> Peptidase
EnzymologyBRENDA database
Proteolytic eventsCutDB database (1 cleavage)
PhysiologyProcessing of numerous bacterial secreted lipoproteins.
Pharmaceutical relevanceReported to be a major virulence determinant of Mycobacterium tuberculosis and perhaps a promising new drug target (Sander et al., 2004).
Pathways KEGGProtein export
Other databases PANTHER
Relevant inhibitors globomycin