Alignment for family S9
43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71
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
# # #
1 -GITSTDFETKQVRYKS-KD--GTV------------VPMFVVGRRGA----------EGAS------------PCLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISLNPS-FSA-ARLLFIKHYGAR-----F----------------------------------------CL------A-N---IR-GG----GE-----YG-EEWHS--G-GTLN-------QK-----------QNVFDD--FMYA----------------------------------------------A-----------------------------K--YL-------------------------------------------------P-AKGYT-TKD--------------------------------------------------------Q----L-AI--M-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGACV-------------------------------------N------------------------------------------QHP-E-LFGAA--VAQ------------------------------------------------------------------------------------------------------VGVM-------D---MLRF----------------------------------DEFTIGYAWRSDFGSSKATEE------------------------------------------------QFKTLRAYSP---------------------------------------------------------------------------------------------------------------V---HNVDPKS---PP-----------------YPA-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LT-T-----GDHDD--RVCP----------------LHSYKY---------------------------IAELQ----------HTIGS----R-----PGEKKPL---LIRIDRD-S----------------------------------GH----------------------------GGG-KPTAKV--------LAEAADTYAFIAKHTGASWTP 1
2 EGLLVDDFVTEQTFYNS-SD--GVR------------IPMFIVYRKG---------SVSSES------------PLLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNIPLTPA-FSS-SRMVFLRDLGGV-----L----------------------------------------AV------L-N---IR-GG----GE-----YG-EEWHD--A-GRRA-------CK-----------QNCFTD--FIEG----------------------------------------------A-----------------------------K--FL-------------------------------------------------H-RQGYG-SPQ--------------------------------------------------------T----T-AI--M-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAAVA-------------------------------------N------------------------------------------QAP-E-LFRCV--VCR------------------------------------------------------------------------------------------------------VGVL-------D---MYKF----------------------------------HKFTIGHAWKSDYGD-PEKEE------------------------------------------------DFRVLQQYSP---------------------------------------------------------------------------------------------------------------L---HNIKSGI---K------------------YPA-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-T-----GDHDD--RVVP----------------LHSLKY---------------------------VATLQ----------HMN------------PNEGGPF---LARIEVA-A----------------------------------GH----------------------------GAG-KPTSKI--------LREAGDIYTFIAKNINASWKE 2
3 KDFDPSQFEAEQVFYPS-KD--GTK------------IPMFLVKRKNA--------PKNGEL------------PVYLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISLTPA-FSV-SRLVFVQHFNGM-----L----------------------------------------AL------P-N---LR-GG----GE-----YG-EQWHQ--D-GMLH-------KK-----------QNVFDD--FHGA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-KEGYT-NSE--------------------------------------------------------K----I-AI--H-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAATS-------------------------------------N------------------------------------------QRP-D-LYRCV--VGA------------------------------------------------------------------------------------------------------VGVM-------D---MLRF----------------------------------HKFTIGHAWRTDYGD-PDVAD------------------------------------------------DFHYIRRYSP---------------------------------------------------------------------------------------------------------------V---HNVP-QA---D------SPIMQKLAGRGGFPS-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LT-T-----GDHDD--RVVP----------------LHSYKL---------------------------IAELQ----------RQLGN----S-----ETQTNPL---LIRIDTK-S----------------------------------GH----------------------------GAG-KPTTKI--------IEETSEVFAFIAWNL------ 3
4 KGFDSSLFETRQVFYSS-KD--GTS------------VPMFLIYKKGL--------ELNGNT------------PCYLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISVTPS-FNV-SRLVFIQNMGGM-----C----------------------------------------AV------A-N---IR-GG----GE-----YG-EKWHK--D-GCLS-------KK-----------QNVFDD--FISA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-ENKYT-KPN--------------------------------------------------------R----L-AI--S-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVTVCM-------------------------------------N------------------------------------------QRP-D-LFKCV--VAN------------------------------------------------------------------------------------------------------VSVT-------D---MLNF----------------------------------HKYTIGHAWTSEYGC-SDNKE------------------------------------------------DFEFLIKYSP---------------------------------------------------------------------------------------------------------------L---HNVCKQS---S---------YQ-------YPA-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHSYKL---------------------------IAELQ----------HKLTG----N-----EHQENPL---LIRVDTE-S----------------------------------GH----------------------------GAG-KPTSKS--------IEELSDVFFFIASMVGTDW-- 4
5 -GFDSSIFETKQVFFPS-KD--GTK------------IPMFIVHREGI--------ELDGSH------------PLLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPY-YST-SRVIFMQHLGGI-----V----------------------------------------AI------A-N---IR-GG----GE-----YG-EQWHK--E-GIFA-------KR-----------QNAYDD--FQSA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-REKYT-SSE--------------------------------------------------------R----L-VI--Q-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVCCCA-------------------------------------N------------------------------------------QRP-D-LFKCV--ISQ------------------------------------------------------------------------------------------------------VGVL-------D---LLRF----------------------------------HKFTIGHAWVTDYGN-PDNDA------------------------------------------------DFQWLHKLSP---------------------------------------------------------------------------------------------------------------L---HNIS-VP---E------GS-AQ-------YPA-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHSFKF---------------------------IAQLH----------HTMSG----I-----EKQTNPL---MIRIEEK-A----------------------------------GH----------------------------GGG-KPTAKI--------IDETADTYSFIARNLNISW-- 5
6 KDIDISELVTSQVFFKS-KD--GTT------------IPMFIVHKKGI--------ELNGSH------------PTLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISLTPF-FSV-SRLMFIYHLGGI-----L----------------------------------------AV------P-N---IR-GG----GE-----YG-EKWHK--A-GVKD-------KK-----------QNVFDD--FIGA----------------------------------------------A-----------------------------E--FL-------------------------------------------------I-DNKYT-SSR--------------------------------------------------------L----I-AI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVCACM-------------------------------------N------------------------------------------QRP-D-LFRCV--ISQ------------------------------------------------------------------------------------------------------VGVL-------D---MLKF----------------------------------HKFTIGHAWTTDYGCASDSEE------------------------------------------------EFNYLIKYSP---------------------------------------------------------------------------------------------------------------L---HSI-KAS---S------NPNIQ-------YPA-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-T-----ADHDD--RVVP----------------LHSYKF---------------------------IAAIQ----------HELGS----L-----PHQINPL---LIRIETK-A----------------------------------GH----------------------------GAG-KPTAKI--------IEEAADMYAVIAENLNLSW-- 6
7 KGIDASDYQTVQIFYPS-KD--GTK------------IPMFIVHKKGI--------KLDGSH------------PAFLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPN-YSV-SRLIFVRHMGGI-----L----------------------------------------AV------A-N---IR-GG----GE-----YG-ETWHK--G-GILA-------NK-----------QNCFDD--FQCA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-KEGYT-SPK--------------------------------------------------------R----L-TI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAACA-------------------------------------N------------------------------------------QRP-D-LFGCV--IAQ------------------------------------------------------------------------------------------------------VGVM-------D---MLKF----------------------------------HKYTIGHAWTTDYGC-SDSKQ------------------------------------------------HFEWLVKYSP---------------------------------------------------------------------------------------------------------------L---HNVK-LP---E------ADDIQ-------YPS-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHSLKF---------------------------IATLQ----------YIVGR----S-----RKQSNPL---LIHVDTK-A----------------------------------GH----------------------------GAG-KPTAKV--------IEEVSDMFAFIARCLNVDWIP 7
8 KGIDASDYQTVQIFYPS-KD--GTK------------IPMFIVHKKGI--------KLDGSH------------PAFLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPN-YSV-SRLIFVRHMGGV-----L----------------------------------------AV------A-N---IR-GG----GE-----YG-ETWHK--G-GILA-------NK-----------QNCFDD--FQCA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-KEGYT-SPK--------------------------------------------------------R----L-TI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVATCA-------------------------------------N------------------------------------------QRP-D-LFGCV--IAQ------------------------------------------------------------------------------------------------------VGVM-------D---MLKF----------------------------------HKYTIGHAWTTDYGC-SDSKQ------------------------------------------------HFEWLIKYSP---------------------------------------------------------------------------------------------------------------L---HNVK-LP---E------ADDIQ-------YPS-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHSLKF---------------------------IATLQ----------YIVGR----S-----RKQNNPL---LIHVDTK-A----------------------------------GH----------------------------GAG-KPTAKV--------IEEVSDMFAFIARCLNIDWIP 8
9 KGIDASDYQTVQIFYPS-KD--GTK------------IPMFIVHKKGI--------KLDGSH------------PAFLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPN-YSV-SRLIFVRHMGGV-----L----------------------------------------AV------A-N---IR-GG----GE-----YG-ETWHK--G-GILA-------NK-----------QNCFDD--FQHA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-KEGYT-SPK--------------------------------------------------------R----L-TI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAACA-------------------------------------N------------------------------------------QRP-D-LFGCV--IAQ------------------------------------------------------------------------------------------------------VGVM-------D---MLKF----------------------------------HKYTIGHAWTTDYGC-SDSKQ------------------------------------------------HFEWLIKYSP---------------------------------------------------------------------------------------------------------------L---HNVK-LP---E------ADDIQ-------YPS-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHSLKF---------------------------IATLQ----------YIVGR----S-----RKQSNPL---LIHVDTK-A----------------------------------GH----------------------------GAG-KPTAKV--------IEEVSDMFAFIARCLNIDWI- 9
10 KGIDASDYQTVQIFYPS-KD--GTK------------IPMFIVHKKGI--------KLDGSH------------PAFLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPN-YSV-SRLIFVRHMGGV-----L----------------------------------------AV------A-N---IR-GG----GE-----YG-ETWHK--G-GILA-------NK-----------QNCFDD--FQHA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-KEGYT-SPK--------------------------------------------------------R----L-TI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAACA-------------------------------------N------------------------------------------QRP-D-LFGCV--IAQ------------------------------------------------------------------------------------------------------VGVM-------D---MLKF----------------------------------HKYTIGHAWTTDYGC-SDSKQ------------------------------------------------HFEWLIKYSP---------------------------------------------------------------------------------------------------------------L---HNVK-LP---E------ADDIQ-------YPS-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHSLKF---------------------------IATLQ----------YIVGR----S-----RKQSNPL---LIHVDTK-A----------------------------------GH----------------------------GAG-KPTAKV--------IEEVSDMFAFIARCLNIDWI- 10
11 KGIDASDYQTIQIFYPS-KD--GTK------------IPMFIVHKKGI--------KLDGSH------------PAFLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPN-YSV-SRLIFVRHMGGV-----L----------------------------------------AV------A-N---IR-GG----GE-----YG-ETWHK--G-GILA-------NK-----------QNCFDD--FQRA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-KEGYT-SPK--------------------------------------------------------R----L-TI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAACA-------------------------------------N------------------------------------------QRP-D-LFGCV--IAQ------------------------------------------------------------------------------------------------------VGVM-------D---MLKF----------------------------------HKYTIGHAWTTDYGC-SDSEQ------------------------------------------------HFDWLIKYSP---------------------------------------------------------------------------------------------------------------L---HNVK-LP---D------ADDIQ-------YPS-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHSLKF---------------------------IATLQ----------YIVGR----S-----RKQSNPL---LIHVDTK-A----------------------------------GH----------------------------GAG-KPTAKV--------IEEVSDMFAFIARCLNIDWI- 11
12 KGIDASDYQTIQIFYPS-KD--GTK------------IPMFIVHKKGI--------KLDGSH------------PAFLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPN-YSV-SRLIFVRHMGGV-----L----------------------------------------AV------A-N---IR-GG----GE-----YG-ETWHK--G-GILA-------NK-----------QNCFDD--FQRA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-KEGYT-SPK--------------------------------------------------------R----L-TI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAACA-------------------------------------N------------------------------------------QRP-D-LFGCV--IAQ------------------------------------------------------------------------------------------------------VGVM-------D---MLKF----------------------------------HKYTIGHAWTTDYGC-SDSEQ------------------------------------------------HFDWLIKYSP---------------------------------------------------------------------------------------------------------------L---HNVK-LP---D------ADDIQ-------YPS-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHSLKF---------------------------IATLQ----------YIVGR----S-----RKQSNPL---LIHVDTK-A----------------------------------GH----------------------------GAG-KPTAKV--------IEEVSDMFAFIARCLNIDWI- 12
13 -GIDASDYQTVQIFYPS-KD--GTK------------IPMFIVHKKGI--------KLDGSH------------PAFLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPN-YSV-SRLIFVRHMGGV-----L----------------------------------------AV------A-N---IR-GG----GE-----YG-ETWHK--G-GILA-------NK-----------QNCFDD--FQHA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-KEGYT-SPK--------------------------------------------------------R----L-TI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAACA-------------------------------------N------------------------------------------QRP-D-LFGCV--IAQ------------------------------------------------------------------------------------------------------VGVM-------D---MLKF----------------------------------HKYTIGHAWTTDYGC-SDSKQ------------------------------------------------HFEWLIKYSP---------------------------------------------------------------------------------------------------------------L---HNVR-LP---E------ADDTQ-------YPS-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHSLKF---------------------------IATLQ----------YVVGR----S-----RKQSNPL---LIHVDTK-A----------------------------------GH----------------------------GAG-KPTAKV--------IEEVSDMFAFIARCLDIDWIQ 13
14 KGIDASDYQTVQIFYPS-KD--GTK------------IPMFIVHKKGI--------KLDGSH------------PAFLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPN-YSV-SRLIFVRHMGGV-----L----------------------------------------AV------A-N---IR-GG----GE-----YG-ETWHK--G-GILA-------NK-----------QNCFDD--FQHA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-KEGYT-SPK--------------------------------------------------------R----L-TI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAACA-------------------------------------N------------------------------------------QRP-D-LFGCV--IAQ------------------------------------------------------------------------------------------------------VGVM-------D---MLKF----------------------------------HKYTIGHAWTTDYGC-SDSKQ------------------------------------------------HFEWLIKYSP---------------------------------------------------------------------------------------------------------------L---HNVR-LP---E------ADDTQ-------YPS-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHSLKF---------------------------IATLQ----------YVVGR----S-----RKQSNPL---LIHVDTK-A----------------------------------GH----------------------------GAG-KPTAKV--------IEEVSDMFAFIARCLDIDWI- 14
15 KGIDAADYQTIQIFYPS-KD--GTK------------IPMFIVHKKGI--------KLDGSH------------PAFLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPN-YSV-SRLIFVRHMGGV-----L----------------------------------------AV------A-N---IR-GG----GE-----YG-ETWHK--G-GILA-------NK-----------QNCFDD--FQCA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-KEGYT-SPK--------------------------------------------------------R----L-TI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAACA-------------------------------------N------------------------------------------QRP-D-LFGCV--IAQ------------------------------------------------------------------------------------------------------VGVM-------D---MLKF----------------------------------HKFTIGHAWTTDYGC-SDTKQ------------------------------------------------HFEWLLKYSP---------------------------------------------------------------------------------------------------------------L---HNVK-LP---E------ADDIQ-------YPS-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHSLKF---------------------------IATLQ----------YIVGR----S-----RKQSNPL---LIHVDTK-A----------------------------------GH----------------------------GAG-KPTAKV--------IEEVSDMFAFIARCLNIEWI- 15
16 KGIDAADYQTIQIFYPS-KD--GTK------------IPMFIVHKKGI--------KLDGSH------------PAFLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPN-YSV-SRLIFVRHMGGV-----L----------------------------------------AV------A-N---IR-GG----GE-----YG-ETWHK--G-GILA-------NK-----------QNCFDD--FQCA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-KEGYT-SPK--------------------------------------------------------R----L-TI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAACA-------------------------------------N------------------------------------------QRP-D-LFGCV--IAQ------------------------------------------------------------------------------------------------------VGVM-------D---MLKF----------------------------------HKFTIGHAWTTDYGC-SDTKQ------------------------------------------------HFEWLLKYSP---------------------------------------------------------------------------------------------------------------L---HNVK-LP---E------ADDIQ-------YPS-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHSLKF---------------------------IATLQ----------YIVGR----S-----RKQSNPL---LIHVDTK-A----------------------------------GH----------------------------GAG-KPTAKV--------IEEVSDMFAFIARCLNIEWIQ 16
17 KGIDASDYQTVQIFYPS-KD--GTK------------IPMFIVHKKGI--------KLDGSH------------PAFLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPN-YSV-CRLIFVRHMGGV-----L----------------------------------------AV------A-N---IR-GG----GE-----YG-ETWHK--G-GILA-------NK-----------QNCFDD--FQCA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-KEGYT-SPK--------------------------------------------------------R----L-TI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVATCA-------------------------------------N------------------------------------------QRP-D-LFGCV--IAQ------------------------------------------------------------------------------------------------------VGVM-------D---MLKF----------------------------------HKYTIGHAWTTDYGC-SDNKQ------------------------------------------------HFEWLIKYSP---------------------------------------------------------------------------------------------------------------L---HNVK-LP---E------ADDIQ-------YPS-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHSPKF---------------------------IATLQ----------HLVGR----S-----RKQNNPL---LIHVDTK-A----------------------------------GH----------------------------GAG-KPTAKV--------IEEVSDMFAFIARCLNIDWIQ 17
18 KGFDPSVYQTIQVFYPS-KD--GTK------------IPMFIIHKKGI--------KLDGSH------------PAFLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPS-YSV-SRLIFVRHLGGV-----L----------------------------------------AV------A-N---IR-GG----GE-----YG-ETWHK--G-GILA-------NK-----------QNCFDD--FQYA----------------------------------------------A-----------------------------K--YL-------------------------------------------------I-REGYT-SPK--------------------------------------------------------K----L-TI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAACA-------------------------------------N------------------------------------------QRP-D-LFGCV--IAQ------------------------------------------------------------------------------------------------------VGVM-------D---MLKF----------------------------------HKYTIGHAWTTDYGC-SDHKE------------------------------------------------QFEWLCKYSP---------------------------------------------------------------------------------------------------------------L---HNVK-LP---E------EDGIQ-------YPA-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHSLKF---------------------------IATLQ----------YVVGR----S-----RKQTNPL---LIHVDTK-A----------------------------------GH----------------------------GAG-KPTAKV--------IEEVSDMFAFIARCLNLDWI- 18
19 KGFDPSVYQTIQVFYPS-KD--GTK------------IPMFIIHKKGI--------KLDGSH------------PAFLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPS-YSV-SRLIFVRHLGGV-----L----------------------------------------AV------A-N---IR-GG----GE-----YG-ETWHK--G-GILA-------NK-----------QNCFDD--FQYA----------------------------------------------A-----------------------------K--YL-------------------------------------------------I-REGYT-APK--------------------------------------------------------K----L-TI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAACA-------------------------------------N------------------------------------------QRP-D-LFGCV--IAQ------------------------------------------------------------------------------------------------------VGAM-------D---MLKF----------------------------------HKYTIGHAWTTDYGC-SDHKE------------------------------------------------QFEWLCKYSP---------------------------------------------------------------------------------------------------------------L---HNVK-LP---E------EDGIQ-------YPA-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHSLKF---------------------------IATLQ----------YVVGR----S-----RKQTNPL---LIHVDTK-A----------------------------------GH----------------------------GAG-KPTAKV--------IEEVSDMFAFIARCLNLDWIE 19
20 KGFDPSAYQTVQVFYPS-KD--GTM------------IPMFVVHKKGI--------KLDGSH------------PAFLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPS-YSV-SRLIFIRHLGGI-----M----------------------------------------AV------A-N---IR-GG----GE-----YG-ETWHK--G-GILA-------NK-----------QNCFND--FQHA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-KEGYT-SPK--------------------------------------------------------K----L-TI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAACA-------------------------------------N------------------------------------------QRP-D-LFGCV--IAQ------------------------------------------------------------------------------------------------------VGVM-------D---MLKF----------------------------------HKFTIGHAWTTDFGC-SDYKE------------------------------------------------QFEWLYKYSP---------------------------------------------------------------------------------------------------------------L---HNIK-IP---E------GDGVQ-------YPA-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHSLKF---------------------------IATLQ----------YVLGR----N-----PKQANPL---LIHVDTK-A----------------------------------GH----------------------------GAG-KPTAKV--------IEEASDMYAFIARCLNLEWIE 20
21 KGFNPADYQTTQVFYPS-KD--GTQ------------IPMFIVHKKGI--------KMDGSH------------PAFLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPS-YSV-SRLIFIRHLGGV-----L----------------------------------------AV------A-N---IR-GG----GE-----YG-ETWHK--G-GMLA-------NK-----------QNCFTD--FQCA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-KEGYT-SPK--------------------------------------------------------K----L-TI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAACV-------------------------------------N------------------------------------------QRP-D-LFGCA--VAQ------------------------------------------------------------------------------------------------------VGVM-------D---MLKF----------------------------------HKFTIGHAWTTDFGC-SEIKE------------------------------------------------QFDWLIKYSP---------------------------------------------------------------------------------------------------------------L---HNIQ-VP---E------GDGVQ-------YPA-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----GDHDD--RVVP----------------LHSLKY---------------------------IATLQ----------NVIGQ----C-----PGQKNPL---FIYIDTK-S----------------------------------GH----------------------------GAG-KPTSKV--------IQEVADTYAFIARCLNLSWL- 21
22 KGFNPDLFTTKQVFYAS-KD--GTK------------IPMFIVHKKDI--------ELTGDH------------PTLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FSISITPS-YSV-SRVIFMQNLGGL-----I----------------------------------------AV------A-N---IR-GG----GE-----YG-ETWHK--A-GSVR-------NK-----------QNCFDD--FQSA----------------------------------------------A-----------------------------Q--FL-------------------------------------------------T-DNKYT-RPS--------------------------------------------------------K----L-TI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGACI-------------------------------------N------------------------------------------QRP-E-LFGCA--VAQ------------------------------------------------------------------------------------------------------VGVM-------D---MLKF----------------------------------HKYTIGHAWTTDYGC-SDDCD------------------------------------------------DFNCLVKYSP---------------------------------------------------------------------------------------------------------------L---HNVKSVP---S------------------YPS-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----GDHDD--RVVP----------------HHSLKY---------------------------IATLQ----------DLVGR----S-----PDQRNPL---LIRVDTK-S----------------------------------GH----------------------------GSG-KPTSKI--------IEEASDMYGFIARCVEAHW-- 22
23 KGFDQSQFQTVQVFFSS-KD--GTK------------IPMFIVHRKGI--------ELDGSH------------PVLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPG-FSV-SRIVFIQHLGGI-----L----------------------------------------AI------P-N---IR-GG----GE-----YG-ETWHK--G-GMLA-------NK-----------QNCFDD--FQFA----------------------------------------------A-----------------------------Q--WL-------------------------------------------------I-ENKYT-SAN--------------------------------------------------------K----I-TL--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAACA-------------------------------------N------------------------------------------QRP-D-LFGCI--INQ------------------------------------------------------------------------------------------------------VGVM-------D---MLKF----------------------------------HKFTIGHAWITDFGC-SEKKD------------------------------------------------NFEYLIKYSP---------------------------------------------------------------------------------------------------------------L---HNIK-SP---D------GD-TQ-------YPS-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHSLKY---------------------------IAELQ----------HTMGS----E-----SKQTNPL---MIRLDTK-A----------------------------------GH----------------------------GAG-KPTAKV--------IEEYSDVYGFIAENLKVEW-- 23
24 KDFDPSGFQTDQVFFSS-KD--GTK------------VPMFIVHKKDI--------PLDGTH------------PVLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPS-FSV-SRIVFMLHLGGI-----L----------------------------------------AV------P-N---IR-GG----GE-----YG-EIWHK--A-GTKE-------KK-----------QNVFDD--FQGA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-KNKYT-SAS--------------------------------------------------------K----I-TI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGACV-------------------------------------N------------------------------------------QRP-D-LFGCA--VSQ------------------------------------------------------------------------------------------------------VPVM-------D---MLKF----------------------------------HKFTIGHAWTTDFGC-SDNKE------------------------------------------------GFDYLIKYSP---------------------------------------------------------------------------------------------------------------L---HNIQ-TP---S------DSVVQ-------YPA-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----GDHDD--RVVP----------------LHSLKF---------------------------IAQLQ----------HTVGS----N-----PKQTNPL---FIRVDTK-S----------------------------------GH----------------------------GFG-KPTAKV--------IEETSDIYAFIAENLKLEW-- 24
25 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-----YG-ETWHK--G-GMLA-------NK-----------QNCFDD--FQCA----------------------------------------------A-----------------------------K--YL-------------------------------------------------I-ENKYT-APQ--------------------------------------------------------K----I-AI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGACC-------------------------------------N------------------------------------------QAP-E-LFGCV--ICQ------------------------------------------------------------------------------------------------------VG-----------------------------------------------------------WTS--------------------------------------------------------------WFSYSP---------------------------------------------------------------------------------------------------------------L---HNMK-CP---E------GD-AQ-------YPS-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----GDHDD--RVSP----------------LHSLKY---------------------------IATLQ----------EIVGA----S-----EKQKNPL---MIRIDTK-S----------------------------------GH----------------------------GFG-KPTEKV--------IEEYSDIYAFIAAALKAQW-- 25
26 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K--YL-------------------------------------------------I-ENKYT-APQ--------------------------------------------------------K----I-AI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGACC-------------------------------------N------------------------------------------QAP-E-LFGCV--ICQ------------------------------------------------------------------------------------------------------VG-------------------------------------------------------------------------------------------------------------------------------YSP---------------------------------------------------------------------------------------------------------------L---HNMK-CP---E------GD-AQ-------YPS-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----GDHDD--RVSP----------------LHSLKY---------------------------IATLQ----------EIVGA----S-----EKQKNPL---MIRIDTK-S----------------------------------GH----------------------------GFG-KPTEKV--------IEEYSDIYAFIAAALKAQWTD 26
27 KGFDASAFETTQVFYPS-KD--GTK------------IPMFIVHKKGL--------KKTGDH------------PVLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPS-FSV-SRIVFIQNLGGV-----L----------------------------------------AV------P-N---IR-GG----GE-----YG-ETWHK--G-GMLA-------NK-----------QNCFDD--FQCA----------------------------------------------A-----------------------------K--YL-------------------------------------------------I-ENKYT-APQ--------------------------------------------------------K----I-AI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGACC-------------------------------------N------------------------------------------QAP-E-LFGCV--ICQ------------------------------------------------------------------------------------------------------VGXLLCNPPPPP---LLPY----------------------------------NVRIIINDYFL--------------------------------------------------------------APRYSP---------------------------------------------------------------------------------------------------------------L---HNMK-CP---E------GD-AQ-------YPS-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----GDHDD--RVSP----------------LHSLKY---------------------------IATLQ----------EIVGA----S-----EKQKNPL---MIRIDTK-S----------------------------------GH----------------------------GFG-KPTEKV--------IEEYSDIYAFIAAALKAQW-- 27
28 KNFDFDQYETKQIFYPS-KD--GTK------------IPMFIVKKKDM--------PLDGDN------------PCLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISISPH-FSV-SRMVFMQHLGGV-----F----------------------------------------AV------A-N---IR-GG----GE-----YG-DDWHK--G-GRFG-------NK-----------QNVFDD--FQAA----------------------------------------------A-----------------------------Q--YL-------------------------------------------------I-DNKYT-SAK--------------------------------------------------------K----L-VI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGACM-------------------------------------N------------------------------------------QRP-D-LFGCG--IAQ------------------------------------------------------------------------------------------------------VGVM-------D---MLKF----------------------------------HKFTIGHAWTTDYGC-SDKED------------------------------------------------QFPYLIKYSP---------------------------------------------------------------------------------------------------------------L---HNIK-VP---D------GD-TQ-------YPA-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----GDHDD--RVVP----------------SHSLKF---------------------------MAELQ----------HTLKD----C-----QKQTNPI---MIRVDTK-A----------------------------------GH----------------------------GSG-KPTAKI--------IEELTDIYSFIILTAGATW-- 28
29 ---------------------------------------MFLVHQRGI--------KKDGSH------------PVFLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FEHSIQPH-YNT-AYLLFIRHLGGI-----L----------------------------------------AI------A-N---IR-GG----GE-----YG-QTWHK--A-GTLG-------NK-----------QNCFDD--FQSA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-QQNFT-SAS--------------------------------------------------------R----I-AI--N-G--AS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAACV-------------------------------------N------------------------------------------QRP-E-LFGCA--VME------------------------------------------------------------------------------------------------------VGVM-------D---MLKF----------------------------------HKFTIGHAWTTDYGC-SDDPE------------------------------------------------QFQWLIKYSP---------------------------------------------------------------------------------------------------------------L---HN---LP---Q------CNGPV-------FPA-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHTLKY---------------------------VATVQ----------HTVGR----N-----PAQKQPL---LVRVDTK-S----------------------------------GH----------------------------GAG-KPTAKA--------ILEDTHIFSFIAHTLGLQW-- 29
30 ------------VFYPS-KD--GTQ------------IPMFLVHQRGI--------KKDGSH------------PVFLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FEHSIQPH-YNT-AYLLFIRHLGGI-----L----------------------------------------AI------A-N---IR-GG----GE-----YG-QTWHK--A-GTLG-------NK-----------QNCFDD--FQSA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-QQNFT-SAS--------------------------------------------------------R----I-AI--N-G--AS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAACV-------------------------------------N------------------------------------------QRP-E-LFGCA--VME------------------------------------------------------------------------------------------------------VGVM-------D---MLKF----------------------------------HKFTIGHAWTTDYGC-SDDPE------------------------------------------------QFQWLIKYSP---------------------------------------------------------------------------------------------------------------L---HN---LP---Q------CNGPV-------FPA-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHTLKY---------------------------VATVQ----------HTVGR----N-----PAQKQPL---LVRVDTK-S----------------------------------GH----------------------------GAG-KPTAKA--------ILEDTHIFSFIAHTLGLQW-- 30
31 -GFDPSLFETQQVFYPS-KD--GTR------------IPMFIVKKKTV--------VLDGTN------------PCLMY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISLEPA-FSV-TRIVFMQHFNGV-----F----------------------------------------AV------P-N---IR-GG----GE-----YG-EAWHD--G-GRLF-------NK-----------QNSFDD--FHSA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-ANGYT-SSS--------------------------------------------------------K----L-AI--Q-G--AS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LIGACV-------------------------------------N------------------------------------------QRP-E-LYAAG--IAH------------------------------------------------------------------------------------------------------VGVM-------D---MLRF----------------------------------HKFTVGYCWVSDYGS-PEEKA------------------------------------------------AFENLLKFSP---------------------------------------------------------------------------------------------------------------L---HNLK-VP---E------TG--Q-------YPA-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHSLKY---------------------------MAQMH----------HTFRD----C-----PKQTNPL---MIRIETK-A----------------------------------GH----------------------------GAN-KPTSKI--------IDEHSDVFAFLARALNLEF-- 31
32 -GFDRTAFQVTQVFYPS-KD--GTE------------IPMFIVARKDI--------KLDGSH------------PCLLY----A-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FSISMTPF-FSA-TRIVLSRHLGTV-----F----------------------------------------CF------A-N---IR-GG----GE-----YG-EEWHK--S-GALA-------NK-----------QNCFDD--FISG----------------------------------------------A-----------------------------E--YL-------------------------------------------------V-SAGYT-QPR--------------------------------------------------------K----L-CI--E-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I-LVGACI-------------------------------------N------------------------------------------QRP-D-LFGCA--LAH------------------------------------------------------------------------------------------------------VGVM-------D---MLRF----------------------------------HKFTIGHAWTSEFGC-SDKEE------------------------------------------------EFHWLIKYSP---------------------------------------------------------------------------------------------------------------L---HNVKRPW---EQKT---DLFVQ-------YPS-------------------------TM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHSYKL---------------------------LATMQ----------YELGL----SLEN--SPQTNPI---IARIEVK-A----------------------------------GH----------------------------GAG-RPTQKM--------IDEAADRYSFMAKMVDASWI- 32
33 PGFDRTAFQVTQVFYPS-KD--GTD------------IPMFIVARKDI--------KLDGSH------------PCLLY----A-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FSISMTPF-FSA-TRIVLGRHLGTV-----F----------------------------------------CF------A-N---IR-GG----GE-----YG-EEWHK--S-GALA-------NK-----------QNCFDD--FISG----------------------------------------------A-----------------------------E--YL-------------------------------------------------V-SAGYT-QPR--------------------------------------------------------K----L-CI--E-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I-LVGACI-------------------------------------N------------------------------------------QRP-D-LFGCA--LAH------------------------------------------------------------------------------------------------------VGVM-------D---MLRF----------------------------------HKFTIGHAWTSEFGC-SDKEE------------------------------------------------EFHWLIKYSP---------------------------------------------------------------------------------------------------------------L---HNVKRPW---EQKT---DLFFQ-------YPS-------------------------TM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHSYKL---------------------------LATMQ----------YELGL----SLEN--SPQTNPI---IARIEVK-A----------------------------------GH----------------------------GAG-RPTQKMCNVCELQQIDEAADRYSFMAKMVDASWID 33
34 PGFDREAFQAIQVFYPS-KD--GTK------------IPMFIVAKKDI--------KLDGSH------------PCLLY----A-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPS-FSA-SRIVLSKHLGVV-----F----------------------------------------CF------A-N---IR-GG----GE-----YG-EEWHK--A-GSLA-------KK-----------QNCFDD--FISG----------------------------------------------A-----------------------------E--YL-------------------------------------------------V-SAGYT-QPS--------------------------------------------------------K----L-CI--E-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGACI-------------------------------------N------------------------------------------QRP-D-LYGCA--LAH------------------------------------------------------------------------------------------------------VGVM-------D---MLRF----------------------------------HKFTIGHAWTSDYGC-SENEE------------------------------------------------EFHWLIKYSP---------------------------------------------------------------------------------------------------------------L---HNVKRPW---EQQT---DHLVQ-------YPS-------------------------TM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHSLKL---------------------------LATLQ----------HVLCT----SLDN--SPQMNPI---IGRIEVK-A----------------------------------GH----------------------------GAG-RPTQKM--------IDEAADRYSFMAKMVNASWTE 34
35 -GFDRTSFEVKQIFVPS-KD--GTK------------IPMFIMSKKDI--------ELDGSH------------PTLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPS-FSV-SRLVLCKNMGSV-----V----------------------------------------CI------A-N---IR-GG----GE-----YG-EEWHK--A-GALA-------KK-----------QNCFDD--FIAC----------------------------------------------A-----------------------------E--FL-------------------------------------------------I-SAGYT-SNK--------------------------------------------------------K----I-CI--E-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAACI-------------------------------------N------------------------------------------QRP-D-LFGCA--LAH------------------------------------------------------------------------------------------------------VGVM-------D---MLRF----------------------------------HKFTIGHAWTTDYGC-SDKEE------------------------------------------------EFNWLIKYSP---------------------------------------------------------------------------------------------------------------L---HNVRKPW---EQSF---GNHCQ-------YPA-------------------------TM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------LHSLKL---------------------------LATLQ----------YVLCT----SNED--TRQTNPI---IGRIDRK-S----------------------------------GH----------------------------GAG-RPTKKM--------IDEAADRYSFMAKMLGTTW-- 35
36 -GFDRTGFEAKQVFYQS-KD--GTK------------VPMFIVSKKGI--------DLDGSH------------PTLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FGMSMTPQ-FSA-ARVVLMRNLGLV-----T----------------------------------------CI------A-N---IR-GG----GE-----YG-EGWHR--A-GSLA-------NK-----------QNCFDD--FIAA----------------------------------------------G-----------------------------E--FL-------------------------------------------------V-SAGYT-SPS--------------------------------------------------------R----L-CI--E-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAGCV-------------------------------------N------------------------------------------QRP-G-LFGCA--LAH------------------------------------------------------------------------------------------------------VGVM-------D---MLRF----------------------------------HKFTIGRAWTCDFGC-SENEE------------------------------------------------EFHWLIKYSP---------------------------------------------------------------------------------------------------------------L---HNVRRPW---EKCAGGGGDHRQ-------YPP-------------------------IM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------SHTLKF---------------------------LATMQ----------HVLCT----SLQEHGSPQTNPI---VARIARK-S----------------------------------GH----------------------------GCG-RSTQKI--------IDEAADRYAFAAKMMGLSWI- 36
37 -GFDRTGFEAKQVFYQS-KD--GTK------------VPMFIVSKKGI--------DLDGSH------------PTLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FGMSMTPQ-FSA-ARVVLMRNLGLV-----T----------------------------------------CI------A-N---IR-GG----GE-----YG-EGWHR--A-GSLA-------NK-----------QNCFDD--FIAA----------------------------------------------G-----------------------------E--FL-------------------------------------------------V-SAGYT-SPS--------------------------------------------------------R----L-CI--E-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAGCV-------------------------------------N------------------------------------------QRP-G-LFGCA--LAH------------------------------------------------------------------------------------------------------VGVM-------D---MLRF----------------------------------HKFTIGRAWTCDFGC-SENEE------------------------------------------------EFHWLIKYSP---------------------------------------------------------------------------------------------------------------L---HNVRRPW---EKCAGGGGDHRQ-------YPP-------------------------IM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----ADHDD--RVVP----------------SHTLKF---------------------------LATMQ----------HVLCT----SLQEHGSPQTNPI---VARIARK-S----------------------------------GH----------------------------GCG-RSTQKI--------IDEAADRYAFAAKMMGLSWI- 37
38 -DFDRSEFEVKQVFVPS-KD--GTK------------IPIFIAARKGI--------SLDGSH------------PCEMH----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FGINMMPT-FSA-SRIVFLKHLGGV-----F----------------------------------------CL------A-N---IR-GG----GE-----YG-EEWHK--A-GFRD-------KK-----------QNVFDD--FISA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-SSGYT-KAR--------------------------------------------------------R----V-AI--E-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAACI-------------------------------------N------------------------------------------QRP-D-LFGCA--EAN------------------------------------------------------------------------------------------------------CGVM-------D---MLRF----------------------------------HKFTLGYLWTGDYGC-SDKEE------------------------------------------------EFKWLIKYSP---------------------------------------------------------------------------------------------------------------I---HNVRRPW---EQPG---NEETQ-------YPA-------------------------TM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----ADHDD--RVVP----------------LHSFKL---------------------------LATMQ----------HVLCT----SLED--SPQKNPI---IARIQRK-A----------------------------------AH-----------------------------YG-RATMTQ--------IAEVADRYGFMAKALE----- 38
39 ----ADDYVTKQVFVTS-AD--GTQ------------VPMFITHHKDT--------KLDGSA------------PTLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNVPLEPG-FSP-NRLAFMRGYGGV-----F----------------------------------------AQ------A-N---LR-GG----GE-----YG-TEWRN--A-GSTH-------NK-----------QNVFDD--FQAC----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-RERYC-SPA--------------------------------------------------------K----L-TI--Q-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAACA-------------------------------------N------------------------------------------QRP-D-LYACV--LGQ------------------------------------------------------------------------------------------------------VGVM-------D---MLRF----------------------------------HKFTIGHAWMTDYGN-PDRAA------------------------------------------------DFSWIYPYSP---------------------------------------------------------------------------------------------------------------L---HNVR-AP---E------GGSRQ-------YPA-------------------------IM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LA-T-----GDHDD--RVVP----------------LHTLKL---------------------------LATLQ----------HNLAA----A-DPAASPQRNPL---LARIEVK-A----------------------------------GH----------------------------GAG-KPTQKV--------IAEAADLMGFAAKCMNAKWV- 39
40 ----ADDYVTKQVFVTS-AD--GTQ------------VPMFITHHKDT--------KLDGSA------------PTLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNIALTPG-FSA-SRLAFMRGYGGV-----F----------------------------------------AQ------A-N---LR-GG----GE-----YG-TDWRN--A-GSTH-------NK-----------QNVFDD--FQAC----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-RERYC-SPA--------------------------------------------------------K----L-TI--Q-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAACA-------------------------------------N------------------------------------------QRP-D-LYACV--LGQ------------------------------------------------------------------------------------------------------VGVM-------D---MLRF----------------------------------HKFTIGHAWMTDYGN-PDRAA------------------------------------------------DFSWIYPYSP---------------------------------------------------------------------------------------------------------------L---HNVR-AP---E------GGSRQ-------YPA-------------------------IM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LA-T-----GDHDD--RVVP----------------LHTLKL---------------------------LATLQ----------HNLAA----A-DPAASPQRNPL---LARIEVK-A----------------------------------GH----------------------------GAG-KPTQKV--------IDENVDLFGFAAKCMNAKWV- 40
41 ----ADDYVTKQVFVTS-AD--GTQ------------VPMFITHHKDT--------KLDGSA------------PTLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNIALTPG-FSA-SRLAFMRGYGGV-----F----------------------------------------AQ------A-N---LR-GG----GE-----YG-TDWRN--A-GSTH-------NK-----------QNVFDD--FQAC----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-RERYC-SPA--------------------------------------------------------K----L-TI--Q-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVAACA-------------------------------------N------------------------------------------QRP-D-LYACV--LGQ------------------------------------------------------------------------------------------------------VGVM-------D---MLRF----------------------------------HKFTIGHAWMTDYGN-PDRAA------------------------------------------------DFSWIYPYSP---------------------------------------------------------------------------------------------------------------L---HNVR-AP---E------GGSRQ-------YPA-------------------------IM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LA-T-----GDHDD--RVVP----------------LHTLKL---------------------------LATLQ----------HNLAA----A-DPAASPQRNPL---LARIEVK-A----------------------------------GH----------------------------GAG-KPTQKV--------IDENVDLFGFAAKCMNAKWV- 41
42 -GLCTSDLQTIQVFYES-KD--GTK------------IPMYIISHKDT--------KLDGSN------------STVLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPS-FSV-SWLTYVQHLRGV-----V----------------------------------------AI------A-N---IR-GG----GE-----YGQEKWYD--Q-GRRA-------KK-----------QNVFDD--FQWA----------------------------------------------A-----------------------------K--WL-------------------------------------------------I-ANNYC-RSE--------------------------------------------------------K----I-AI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGACI-------------------------------------N------------------------------------------QAP-E-LFGAA--VAQ------------------------------------------------------------------------------------------------------VGVM-------D---IYRF----------------------------------HKFTIGAAWTSDYGN-PDNAE------------------------------------------------DFAVMKKYSP---------------------------------------------------------------------------------------------------------------L---HNIQKEK---Q------------------YPA-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IM-T-----GDHDD--RVVP----------------LHSHKF---------------------------IAELQ----------HTLKD----N--------VKPL---IERVEVK-A----------------------------------GH----------------------------GAG-KSTQQF--------IEDTTDKFAFIGLATGATW-- 42
43 -----SDLQTIQVFYES-KD--GTK------------IPMYIISHKDT--------KLDGSN------------STVLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISITPS-FSV-SWLTYVQHLRGV-----V----------------------------------------AI------A-N---IR-GG----GE-----YGQEKWYD--Q-GRRA-------KK-----------QNVFDD--FQWA----------------------------------------------A-----------------------------K--WL-------------------------------------------------I-ANNYC-RSE--------------------------------------------------------K----I-AI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGACI-------------------------------------N------------------------------------------QAP-E-LFGAA--VAQ------------------------------------------------------------------------------------------------------VGVM-------D---IYRF----------------------------------HKFTIGAAWTSDYGN-PDNAE------------------------------------------------DFAVMKKYSP---------------------------------------------------------------------------------------------------------------L---HNIQKEK---Q------------------YPA-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IM-T-----GDHDD--RVVP----------------LHSHKF---------------------------IAELQ----------HTLKD----N--------VKPL---IERVEVK-A----------------------------------GH----------------------------GAG-KSTQQF--------IEDTTDKFAFI---------- 43
44 LNFDFDNYETKQVFYTS-KD--GTK------------IPMFIVHKKGL--------KLDGNN------------PTYLY----S-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISLLPS-FST-SRLIFLEN-GGV-----F----------------------------------------AM------P-N---IR-GG----GE-----YG-EEWHK--A-GMLD-------KK-----------QNVFDD--FIAA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-KEGYT-NPG--------------------------------------------------------K----L-SC--A-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LIGAVI-------------------------------------N------------------------------------------QRP-D-LFKVA--LPA------------------------------------------------------------------------------------------------------VGVM-------D---MLRF----------------------------------HKFTIGYYWVVEYGS-SDDPE------------------------------------------------QFKFLYEYSP---------------------------------------------------------------------------------------------------------------L---HNIK--------------ENLN-------YPA-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-T-----ADHDD--RVVP----------------AHSFKY---------------------------IATLQ----------EKYKG-------------ENPV---LIRIETK-A----------------------------------GH----------------------------GAG-KPTSKI--------IEEVADVWSFVFYNLGMQ--- 44
45 VDFNPNDYETKQIFYQS-KD--GTR------------VPMFITHKKGI--------KLDGNN------------PTYLY----A-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNVSMTPS-FSV-SLLVWMEM-GGV-----Y----------------------------------------AM------P-N---IR-GG----GE-----YG-EEWHQ--A-GMKE-------KK-----------QNVFDD--FIGA----------------------------------------------A-----------------------------E--WL-------------------------------------------------I-ANKYT-KTE--------------------------------------------------------K----L-AI--A-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGACI-------------------------------------T------------------------------------------QRP-D-LFGAA--IPS------------------------------------------------------------------------------------------------------VGVM-------D---MLRF----------------------------------HKFTIGWAWTSEFGS-ADNSE------------------------------------------------EFPALYAYSP---------------------------------------------------------------------------------------------------------------L---HNIK--------------PDTA-------YPA-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IT-T-----ADHDD--RVVP----------------AHSFKF---------------------------AAALQ----------EAHAG-------------DAPV---LIRIETK-A----------------------------------GH----------------------------GAG-KPTAKI--------IEEAADKWAFLVRTLDVEV-- 45
46 ---RPEDFETKQVFYES-KD--GTK------------IPMFIVGKKGQ--------EHSGNT------------CTLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FSISITPS-FNP-FRTVFINHFNAL-----L----------------------------------------CV------A-N---IR-GG----GE-----YG-EDWHE--A-GCNNNGKPGKLNK-----------QRGFDD--FQAA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-QQGYT-CPA--------------------------------------------------------K----I-AI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGACV-------------------------------------N------------------------------------------QRP-D-LFAAA--IPQ------------------------------------------------------------------------------------------------------VGVM-------D---MLRF----------------------------------HKFTIGYAWCSDYGCSENSEE------------------------------------------------EFKALYAISP---------------------------------------------------------------------------------------------------------------L---HNIK------P------RDDVQ-------YPA-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-T-----ADHDD--RVVP----------------LHSFKY---------------------------AAQLQ----------YAFEG----N-----SKQTRPL---LIRIETK-S----------------------------------GH----------------------------GAG-KPTAKV--------IEEVADIYAFIGSIT------ 46
47 LPFDPSQFETRQVFVTS-KD--GTR------------VPAFIVARKGL--------VLDGNN------------PTLMY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNVSLPPA-FSA-LRVAFLEQ-GGV-----F----------------------------------------VQ------A-N---LR-GG----GE-----YG-EAWHQ--A-GMKE-------HK-----------QNVFDD--FVAV----------------------------------------------A-----------------------------E--WL-------------------------------------------------I-ANRYT-RSE--------------------------------------------------------R----L-AI--Q-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGAVM-------------------------------------T------------------------------------------QRP-E-LAAVA--LPA------------------------------------------------------------------------------------------------------VGVM-------D---MLRF----------------------------------HTFTIGWNWIADYGS-SADPD------------------------------------------------AFRYLYAYSP---------------------------------------------------------------------------------------------------------------L---HNLR--------------DGVR-------YPA-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IT-T-----ADHDD--RVVP----------------AHSFKF---------------------------AARLQ----------EAHRG-------------DAPV---LIRIETQ-S----------------------------------GH----------------------------GSS-S-LGKQ--------IEETADVYAFVFDQMGV---- 47
48 LDFDAATYEVTQEFAMS-KD--GTR------------VPMFIVARKDA--------PRDGSN------------RTLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FSISLTPA-FSA-SRLAWLER-GGV-----F----------------------------------------VQ------A-N---LR-GG----GE-----YG-EAWHE--A-GTLG-------RK-----------QNVFDD--FAAC----------------------------------------------A-----------------------------E--HL-------------------------------------------------A-RQGWT-RPE--------------------------------------------------------R----L-AI--Q-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGASI-------------------------------------T------------------------------------------QRP-E-LFGAA--VAQ------------------------------------------------------------------------------------------------------VGVL-------D---MLRY----------------------------------HLFTIGWAWASDYGR-SDDPE------------------------------------------------MFATLHAYSP---------------------------------------------------------------------------------------------------------------L---HNLK--------------EGTR-------YPA-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IT-T-----GDHDD--RVVP----------------AHSYKF---------------------------AAELQ----------RVQAG-------------SAPT---LIRIQTR-A----------------------------------GH----------------------------GAG-KPTALV--------IEEAADIWAFLEEVLGG---- 48
49 EGFSRDNYSVEQVFYKS-TD--DTD------------IPMFIVQRKRD--------IAE-PR------------PCLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNYSLMPS-FGI-LSLMFMDTFDGV-----L----------------------------------------AF------P-N---LR-GG----GE-----YG-MEWHN--G-GRML-------SK-----------QNVFND--FQAA----------------------------------------------A-----------------------------E--FL-------------------------------------------------T-KNNYT-TKD--------------------------------------------------------R----L-AI--Q-G--AS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGACI-------------------------------------N------------------------------------------QRP-D-LFGAA--VAQ------------------------------------------------------------------------------------------------------VGVM-------D---MLRF----------------------------------HKFTIGHAWCSDYGN-PDEKV------------------------------------------------HFANLIKFSP---------------------------------------------------------------------------------------------------------------L---HNVH-IP---L------NPNQE-------YPS-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----ADHDD--RVSP----------------LHSYKF---------------------------VAALQ----------EAVRY----S-----EYQLNPI---LLRVYTK-A----------------------------------GH----------------------------GAG-KPTKMR--------ISEATDIITFFKKTLNVD--- 49
50 EGFRREDYAVEQIFYKS-KD--GTK------------VPMFIIRKKRD--------SVE-PR------------PCLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISMLPS-FGL-SGLMFIDTFDGV-----L----------------------------------------AY------P-N---LR-GG----GE-----YG-EKWHN--G-GRLL-------NK-----------QNVFDD--FQAA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-ENKYT-TKD--------------------------------------------------------R----L-AI--Q-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGSCI-------------------------------------N------------------------------------------QRP-D-LFGAA--VAQ------------------------------------------------------------------------------------------------------VGVM-------D---MLRF----------------------------------HKFTIGHAWCSDYGN-PSEKE------------------------------------------------HFDNLYKFSP---------------------------------------------------------------------------------------------------------------L---HNVH-TP---K------GAETE-------YPS-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----ADHDD--RVSP----------------LHSLKF---------------------------IAALQ----------EAVRD----S-----EFQKNPV---LLRVYQK-A----------------------------------GH----------------------------GAG-KPTSKR--------IEEATDILTFLSKSLNVDIVN 50
51 EDFDNSRYAVEQIFYHS-KD--GEK------------VPMFIVQRKQE--------KKE-HK------------PCLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNICVQPS-FSI-TGLVFIDSFDGI-----L----------------------------------------AY------P-N---IR-GG----GE-----YG-ERWHN--A-GRLL-------KK-----------QNVFDD--FQHA----------------------------------------------A-----------------------------Q--YL-------------------------------------------------V-EHGYT-THD--------------------------------------------------------K----I-AI--Q-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGACI-------------------------------------N------------------------------------------QRP-D-LFGAA--IAQ------------------------------------------------------------------------------------------------------VGVM-------D---MLRF----------------------------------HKFTIGRAWVSDYGD-MNEKE------------------------------------------------HFENLLRYSP---------------------------------------------------------------------------------------------------------------L---HNVR-TP---T------SEKDQ-------YPA-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VL-T-----ADHDD--RVSP----------------LHSLKF---------------------------VAALH----------DAIKD----S-----EHQKNPL---LLRVYSK-A----------------------------------GH----------------------------GMG-KPTAKK--------IEEATDILTFMYKTLGLKLSF 51
52 ---DLNQFEVKQVFYES-KD--KTV------------VPMFLILPKNF--------QQNNSA------------PCQLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISVTPS-FSV-GRLFFLMHFGGM-----V----------------------------------------AV------A-N---IR-GG----GE-----YG-KSWHD--A-GRLQ-------NK-----------QNSFDD--FQAA----------------------------------------------A-----------------------------E--YL-------------------------------------------------L-NHGYT-NNQ--------------------------------------------------------K----L-YI--Q-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVCACC-------------------------------------N------------------------------------------QRP-D-LFKAA--VAQ------------------------------------------------------------------------------------------------------VPVC-------D---LIRF----------------------------------HKFTIGHAWKSDYGD-PDNKK------------------------------------------------DFSYLMRISP---------------------------------------------------------------------------------------------------------------L---HNVK-IP---S------NSDVQ-------YPA-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----ADHDD--RVVP----------------LHSFKF---------------------------IATLQ----------EKLCH----N-----CRQTNPI---LIRIEQK-A----------------------------------GH----------------------------GQG-KPTSKS--------INEVVDIYSFLQTAMSLTWKE 52
53 -GFVQSDYVCTQIFYESPKD--KTK------------IPMFIAHRKDF--------VQDGNS------------PFYMT----A-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNIPYSPS-FSL-RNIYFIDKFKGA-----F----------------------------------------AI------A-N---IR-GG----GE-----YG-KKWHE--A-GSLK-------NK-----------QNCFDD--FAGA----------------------------------------------A-----------------------------E--YL-------------------------------------------------F-KNKYT-NPN--------------------------------------------------------R----L-AV--R-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LMGACS-------------------------------------N------------------------------------------QYP-N-IFKCV--IAD------------------------------------------------------------------------------------------------------VGVM-------D---MLKF----------------------------------HKFTIGRHWTSDYGS-SDVPE------------------------------------------------EFDVLIKYSP---------------------------------------------------------------------------------------------------------------L---HNIP-------------SDTKE-------YPS-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IA-T-----GSHDD--RVTP----------------LHSYKF---------------------------AAELQ----------HKLG-----------KKVENPL---LITVTQS-A----------------------------------GH----------------------------GAG-KPLRTI--------LFEQADVFNFISKCINYD--- 53
54 EGFKSSDYECKQVFYESPKD--KTK------------IPMFIAYKKTT-------DITSGNA------------PTYMT----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNISYTQS-FSI-RNIYFLNKFNGI-----F----------------------------------------VI------A-N---IR-GG----GE-----YG-KAWHE--A-GSKK-------NK-----------QNCFDD--FIGA----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-KENYT-NQN--------------------------------------------------------K----L-AV--R-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LMGAIS-------------------------------------N------------------------------------------QRP-D-LFKCV--VAD------------------------------------------------------------------------------------------------------VGVM-------D---MLRF----------------------------------HLHTIGSNWVSDYGR-SDNPD------------------------------------------------DFDVLIKYSP---------------------------------------------------------------------------------------------------------------L---NNVP-------------KDSNQ-------YPS-------------------------IM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LC-T-----GDHDD--RVIP----------------AHSYKF---------------------------ISELQ----------YQLG-----------KKVDTPL---LIRVDKD-S----------------------------------GH----------------------------GAG-KGLSKQ--------NNEIADIFNFFSKVLNVKLNF 54
55 --LDPDDFESTQVWYES-KD--GTK------------IPMFIVRHKST--------KFDGTA------------AAIQY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FATSADPF-FSP-IILTFLQTYGAI-----F----------------------------------------AV------P-S---IR-GG----GE-----FG-EEWHK--G-GRRE-------TK-----------VNTFDD--FIAA----------------------------------------------A-----------------------------Q--FL-------------------------------------------------V-KNKYA-APG--------------------------------------------------------K----V-AI--N-G--AS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVMGSI-------------------------------------V------------------------------------------RAP-EGTFGAA--VPE------------------------------------------------------------------------------------------------------GGVA-------D---LLKF----------------------------------HKFTGGQAWISEYGN-PSIPE------------------------------------------------EFDYIYPLSP---------------------------------------------------------------------------------------------------------------V---HNVRTDK---V------------------MPA-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IT-V-----NIGDG--RVVP----------------MHSFKF---------------------------IATLQ----------HNVPQ----N--------PHPL---LIKIDKSWL----------------------------------GH----------------------------GMG-KPTDKN--------VKDAADKWGFIARALGLE--- 55
56 KGLNPEEFSAEQVWYES-KD--GTK------------IPMFIVRHKST--------PIDGTA------------PAIQY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FSISINPS-FSP-TILTFLKTYGGV-----Y----------------------------------------AI------A-N---IR-GG----GE-----FG-EEWHE--G-GYRD-------KK-----------HNCFDD--FIAA----------------------------------------------T-----------------------------E--YL-------------------------------------------------H-KNKIA-APG--------------------------------------------------------K----V-TI--N-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVSACV-------------------------------------N------------------------------------------RAP-EGTFGAA--VAE------------------------------------------------------------------------------------------------------VGVH-------D---LLRF----------------------------------HKFTIGRAWISDYGD-PDDPK------------------------------------------------DFDFIHPISP---------------------------------------------------------------------------------------------------------------L---HNVSPTK---I------------------LPP-------------------------FM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-T-----ADHDD--RVVP----------------SHSFKL---------------------------AATLQ----------HLRAD----N--------PNPI---LLRVDKK-A----------------------------------GH----------------------------GAG-KSTTKR--------MQEAADKWGFVAKTLGLE--- 56
57 IRFNASPYQTRQVFYPS-KD--GTM------------VPMFIVARKGI--------KLDGTH------------PTIMY----A-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FDITITPR-FDP--ILPVWLELGGV-----Y----------------------------------------AV------P-N---LR-GG----AV-----YG-EKWHH--A-GMLG-------KK-----------QNVFDD--FAWA----------------------------------------------A-----------------------------K--YL-------------------------------------------------Y-QQGYT-SPK--------------------------------------------------------H----L-AI--Q-G--YS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LTGASI-------------------------------------T------------------------------------------ERP-Q-LFGAA--YIG------------------------------------------------------------------------------------------------------HGVL-------D---MLQY----------------------------------QKFSGGSFWVSEYGS-SANQK------------------------------------------------AFDWLIKYSP---------------------------------------------------------------------------------------------------------------L---DNVHKGT---C------------------YPP-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IT-T-----SWDDD--RVVP----------------SHEFKF---------------------------AAKIQ----------QA-------------QGCANPI---LLRTTGS-T----------------------------------AH----------------------------DY--MPTDKE--------IQQDADVWAF----------- 57
58 VPMNPEQYQVEQVFYAS-KD--GTK------------VPMFVVHRKDL--------KRDGNA------------PTLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNVNMEAN-FRS-SILPWLDA-GGV-----Y----------------------------------------AV------A-N---LR-GG----GE-----YG-KAWHD--A-GRLD-------KK-----------QNVFDD--FHAA----------------------------------------------A-----------------------------E--YL-------------------------------------------------V-QQKYT-QPK--------------------------------------------------------R----L-AI--Y-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGAAM-------------------------------------T------------------------------------------QRP-E-LYGAV--VCA------------------------------------------------------------------------------------------------------VPLL-------D---MVRY----------------------------------HLFGSGRTWIPEYGT-AEKPE------------------------------------------------DFKTLHAYSP---------------------------------------------------------------------------------------------------------------Y---HHVRPDV---R------------------YPA-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MM-A-----ADHDD--RVDP----------------MHARKF---------------------------VAAVQ----------NS-------------PGNPATA---LLRIEAN-A----------------------------------GH----------------------------GGA-DQVAKA--------IESSVDLYSFLFQVLDVQGAQ 58
59 -----------QLFYES-HD--GVK------------IPMFICHAHDL--------DLTKPS------------PTLIH----A-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FCSPSAPH-FDP-MFAAFMRNLRGI-----V----------------------------------------AV------A-G---IR-GG----GE-----YG-PKWHE--A-ALGI-------KR-----------WVGWDD--FAWA----------------------------------------------A-----------------------------K--YL-------------------------------------------------Q-GKGLT-IPA--------------------------------------------------------L----T-AT--Y-G--TS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVSAAM-------------------------------------V------------------------------------------RNP-S-LYSVV--FPD------------------------------------------------------------------------------------------------------VAIT-------D---LLRY----------------------------------HKFTLGRIWMDEYGS-PEKAE------------------------------------------------DFPILLATSP---------------------------------------------------------------------------------------------------------------L---HNIDADP---A---------VQ-------YPA-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IT-T-----GDHDT--RVVP----------------SHSLKF---------------------------LAELQ----------AGK------------SENKGVF---LGRIYEN-A----------------------------------GH----------------------------ELGSKPTEKK--------VEEAVDRLVF----------- 59
60 ----QETLVCSQLFYES-HD--GVK------------IPMFICHAHDL--------DLTKPS------------PTLIH----A-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FCSPSAPH-FDP-MFAAFMRNLRGI-----V----------------------------------------AV------A-G---IR-GG----GE-----YG-PKWHE--A-ALGI-------KR-----------WVGWDD--FAWA----------------------------------------------A-----------------------------K--YL-------------------------------------------------Q-GKGLT-IPA--------------------------------------------------------L----T-AT--Y-G--TS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVSAAM-------------------------------------V------------------------------------------RNP-S-LYSVV--FPD------------------------------------------------------------------------------------------------------VAIT-------D---LLRY----------------------------------HKFTLGRIWMDEYGS-PEKAE------------------------------------------------DFPILLATSP---------------------------------------------------------------------------------------------------------------L---HNIDADP---A---------VQ-------YPA-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IT-T-----GDHDT--RVVP----------------SHSLKF---------------------------LAELQ----------AGK------------SENKGVF---LGRIYEN-A----------------------------------GH----------------------------ELGSKPTEKK--------VEEAVDRLVFALYNLK----- 60
61 -----------QLFYES-HD--GVK------------IPMFICHAHDL--------DLTKPN------------PALVH----A-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FCSPSLPR-FDP-MFVAFMRNLRGI-----V----------------------------------------AV------A-G---IR-GG----GE-----YG-PEWHE--A-ALGI-------KR-----------WVGWDD--FAWA----------------------------------------------A-----------------------------K--YL-------------------------------------------------Q-GKGLT-TPA--------------------------------------------------------L----T-AT--Y-G--TS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVSAAM-------------------------------------V------------------------------------------RNP-S-LYSVV--FPD------------------------------------------------------------------------------------------------------VAIT-------D---LLRY----------------------------------HKFTLGRIWMDEYGS-PEKAE------------------------------------------------DFPILHSTSP---------------------------------------------------------------------------------------------------------------L---HSVDGDP---A---------VQ-------YPA-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IT-T-----ADHDT--RVVP----------------SHSLKF---------------------------LAELQ----------ARK------------SENKGVF---LGRIYEN-A----------------------------------GH----------------------------ELGSKPTKKK--------VEEAVDRLVFVLYNLK----- 61
62 -----------QVFYTS-HD--GVR------------IPMFICHPHDL--------DLSRPH------------PLLLH----A-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FCAPLIPH-FDP-MFAVFMRNLRGV-----V----------------------------------------AI------A-G---IR-GG----GE-----YG-KSWHE--A-AIGI-------KR-----------SVGWDD--FAYA----------------------------------------------A-----------------------------R--YV-------------------------------------------------Q-SRGLT-TPS--------------------------------------------------------L----T-AI--Y-G--SS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVSAAT-------------------------------------V------------------------------------------RNP-E-LYSVV--FAD------------------------------------------------------------------------------------------------------VAIT-------D---LIRY----------------------------------HKFTLGRMWMTEYGS-PEEPE------------------------------------------------TLAILHANSP---------------------------------------------------------------------------------------------------------------L---HNVSRDP---S---------VQ-------YPA-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IT-T-----GDHDT--RVVP----------------GHSLKL---------------------------LAELQ----------TLK------------AKNHGAI---LGRVYIN-A----------------------------------GH----------------------------EQSTKSTEKK--------VEEAVDRLVFALDNIKI---- 62
63 -----------QVFYTS-HD--GTR------------IPMFICHPHDL--------DLTRPH------------PLLLH----A-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FCSPLIPH-FDP-MFAVFMRNLRGV-----V----------------------------------------AI------A-G---IR-GG----GE-----YG-KAWHE--A-AIGI-------KR-----------SVGWDD--FAAA----------------------------------------------A-----------------------------R--YV-------------------------------------------------Q-SRGLT-TPS--------------------------------------------------------L----T-AI--Y-G--SS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVSAAT-------------------------------------V------------------------------------------RNP-E-LYSVV--FAD------------------------------------------------------------------------------------------------------VAIT-------D---LIRY----------------------------------HKFTLGRMWMTEYGS-PEEPE------------------------------------------------TLAVLRANSP---------------------------------------------------------------------------------------------------------------L---HNISRDP---S---------VQ-------YPA-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LT-T-----GDHDT--RVVP----------------GHSLKL---------------------------LAELQ----------TLK------------AKNHGAI---LGRVYIN-A----------------------------------GH----------------------------EQSTKSTEKK--------VEEAVDRLVFALDNIKI---- 63
64 ---VEGEFRVEEDFATS-KD--GTK------------VHYFIVKGERD--------EK----------------RAWVF----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNIALTPM-FFP-QV-IPFLKRGGT-----F----------------------------------------IM------A-N---LR-GG----SE-----YG-EEWHR--A-GMRE-------NK-----------QNVFDD--FIAV----------------------------------------------L-----------------------------E--KR-------------------------------------------------K-KEGY-------------------------------------------------------------K----V-AA--W-G--RS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVSATL-------------------------------------T------------------------------------------QRP-D-VMDSA--LIG------------------------------------------------------------------------------------------------------YPVI-------D---MLRF----------------------------------HKLYIGSVWIPEYGN-PEDPK------------------------------------------------DREFLLKYSP---------------------------------------------------------------------------------------------------------------Y---HNVDPKK---K------------------YPP-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IY-T-----GLHDD--RVHP----------------AHALKF---------------------------FMKLK----------EI-------------GA---PV---YLRVETK-S----------------------------------GH----------------------------MGA-SPETRA--------RELTDL-LAFVLKTLS----- 64
65 SPPGLHHLQVRQVWYRS-SG--GVR------------VPMWIASRAGL--------RPDGDL------------PVLLH----A-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FNWAQLPE-FTP-EEALWIEQ-GGV-----F----------------------------------------AL------A-N---IR-GG----NE-----FG-QAWHS--C-GDLA-------HK-----------QNSFDD--FVNA----------------------------------------------A-----------------------------R--WL-------------------------------------------------I-RNHYT-RPA--------------------------------------------------------R----L-AI--Q-G--MS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVMASI-------------------------------------T------------------------------------------QHP-E-LFGAA--IGR------------------------------------------------------------------------------------------------------YPLI-------D---MLGF----------------------------------ESFGIGKWWTSEYGSI-HNAA------------------------------------------------QFRTIYAYSP---------------------------------------------------------------------------------------------------------------Y---QHVVKGT---R------------------YPA-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-T-----GDGDT--RVDP----------------ANSLKM---------------------------TAKLQ----------AATAS-------------GKPV---LLLYDSA-S----------------------------------GH----------------------------SGV---AAPS------VEIPQIVNELEFL---------- 65
66 -RFNASRLVVEQFEATS-RD--GTR------------IPYFVVRPKSA--------RFDGST------------PTILY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FQIPLLPS-YAG-VMGRLWLEQGNA-----Y----------------------------------------VV------A-N---LR-GG----GE-----YG-PRWHE--A-AQGA-------TK-----------QRTWDD--FIAV----------------------------------------------A-----------------------------E--DL-------------------------------------------------I-RRKIT-SPR--------------------------------------------------------R----L-GV--A-G--GS-----------------QG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGTAF-------------------------------------T------------------------------------------QRP-D-LFNAA--MVE------------------------------------------------------------------------------------------------------VPLF-------D---MVRF----------------------------------TKLAAGASWTGEYGD-PAIPE------------------------------------------------QREWLEAYSP---------------------------------------------------------------------------------------------------------------Y---QKLVPAK---T------------------YPT-------------------------PF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----STKDD--RVHP----------------AHGRKA---------------------------AARLA----------EL-------------GQ---PY---FYYENLD-G----------------------------------GH----------------------------SAA-ANLIED--------ARRVALEYTYASRR------- 66
67 ----------EQLEATS-RD--GTS------------IPYFLVRPKNA--------RFDGTI------------PTLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FQASLLPS-YLG-PVGRLWLEQGNA-----Y----------------------------------------VV------A-N---LR-GG----GE-----FG-PQWHQ--A-AQTA-------TK-----------QTTWDD--FIAV----------------------------------------------A-----------------------------E--DL-------------------------------------------------I-RRKIT-SPS--------------------------------------------------------R----L-GI--I-G--GS-----------------QG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGAAI-------------------------------------T------------------------------------------QRP-E-LFNAA--IIK------------------------------------------------------------------------------------------------------VPLF-------D---MLRY----------------------------------TKLGAGASWIGEYGD-PAIAE------------------------------------------------QRAWIEGYSP---------------------------------------------------------------------------------------------------------------Y---QKLMAGK---T------------------YPA-------------------------PL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----STKDD--RVHP----------------AHGRKA---------------------------AAKLA----------AL-------------GQ---PY---FYYENID-G----------------------------------GH----------------------------SAA-ANLREY--------ARQLALEYTYASRR------- 67
68 --FDASNHIVEQLEATS-RD--GTS------------IPYFLVRPKNA--------RFDGTI------------PTLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FQASLLPS-YLG-PVGRLWLEQGNA-----Y----------------------------------------VV------A-N---LR-GG----GE-----FG-PQWHQ--A-AQTA-------TK-----------QTTWDD--FIAV----------------------------------------------A-----------------------------E--DL-------------------------------------------------I-RRKIT-SPS--------------------------------------------------------R----L-GI--I-G--GS-----------------QG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGAAI-------------------------------------T------------------------------------------QRP-E-LFNAA--IIK------------------------------------------------------------------------------------------------------VPLF-------D---MLRY----------------------------------TKLGAGASWIGEYGD-PAIAE------------------------------------------------QRAWIEGYSP---------------------------------------------------------------------------------------------------------------Y---QKLMAGK---T------------------YPA-------------------------PL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----STKDD--RVHP----------------AHGRKA---------------------------AAKLA----------AL-------------GQ---PY---FYYENID-G----------------------------------GH----------------------------SAA-ANLREY--------ARQLALEYTYASRR------- 68
69 ARFNTDGLTVEKHFAIS-RD--KTE------------VPYFIVYRKGM--------KLDHTA------------PVLQY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FEISILPH-YSP-VMGKLWLEKGGV-----Y----------------------------------------VL------A-N---IR-GG----GE-----YG-PRWHD--S-ALLE-------HR-----------QRAYDD--FFAV----------------------------------------------A-----------------------------E--AV-------------------------------------------------Q-SKGFS-SPK--------------------------------------------------------H----Y-GA--M-G--RS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LMGVAL-------------------------------------T------------------------------------------QRP-E-LFNAI--VCG------------------------------------------------------------------------------------------------------VPLL-------D---MKRF----------------------------------NKLLAGASWMAEYGN-PDLPE------------------------------------------------QWEFISRYSP---------------------------------------------------------------------------------------------------------------F---HNLKTEQ---A------------------YPK-------------------------VY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FF-T-----STKDD--RVHP----------------GHARKM---------------------------AARMD----------QL-------------GY---EF---FYYENIE-G----------------------------------GH----------------------------KGN-ANQKQE--------AMLSALEYLYLMRQL------ 69
70 --FDASSLVSEQFEARS-KD--GTE------------IPYFVVRRRDQ----------NGPV------------PTLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FEVPLLPG-YAG-VRGRLWLEKGNA-----Y----------------------------------------VQ------A-N---IR-GG----GE-----FG-PNWHQ--A-ALKS-------NR-----------QNAFDD--FIAV----------------------------------------------A-----------------------------Q--DL-------------------------------------------------V-KRGIA-TPA--------------------------------------------------------T----L-GI--Q-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LTGVSL-------------------------------------T------------------------------------------QHP-E-LFGAV--IID------------------------------------------------------------------------------------------------------VPLL-------D---MLRY----------------------------------TELPPGASWMAEYGD-PAKPE------------------------------------------------EAEWLAAYSP---------------------------------------------------------------------------------------------------------------Y---QHVEADA---A------------------YPP-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LT-T-----STADD--RVHP----------------GHARKM---------------------------AGRLQ----------AV-------------GHT--KT---LFFEETE-G----------------------------------GH----------------------------GGR-GDRRPQ--------AAQAAMKYVFLQRALN----- 70
71 AFFDAENMAVTQYFATS-DD--GTS------------IPYFVVRRTDA--------DNPG--------------PTLLN----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FETSRTPT-YDG-VLGRLWLARGGT-----Y----------------------------------------AL------A-N---IR-GG----GE-----YG-PGWHT--Q-AMRE-------GR-----------DKVAQD--FAAV----------------------------------------------A-----------------------------T--DL-------------------------------------------------V-TRGIT-TAE--------------------------------------------------------Q----L-GA--R-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LMGIML-------------------------------------T------------------------------------------GYP-E-KFGAL--VCD------------------------------------------------------------------------------------------------------VPLL-------D---MKRY----------------------------------HLLLAGASWMAEYGD-PDNPD------------------------------------------------DWKFISEYSP---------------------------------------------------------------------------------------------------------------Y---QNISANR---K------------------YPP-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MT-T-----STRDD--RVHP----------------GHARKM---------------------------TAALQ----------AA-------------GH---PV---WYYENIE-G----------------------------------GH----------------------------AGA-ADNAQI--------AFKSALSFAFLWRMLAG---- 71
72 --FQHRDMKVTQHFATS-KD--GTR------------VPFFLIA-RDL--------PASSSSSSSSSSSPPPPRPTILY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FQVSMLPN-YQA-DVGAAWLEQGGA-----Y----------------------------------------VV------A-N---IR-GG----GE-----FG-PAWHR--A-AMRE-------KR-----------QRAYED--FFAV----------------------------------------------A-----------------------------E--EL-------------------------------------------------V-AMNVT-RPE--------------------------------------------------------L----L-AC--K-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGNAL-------------------------------------T------------------------------------------QRP-D-LFGAV--ICS------------------------------------------------------------------------------------------------------VPLL-------D---LRRY----------------------------------HKLLAGASWMDEYGD-PDG-E------------------------------------------------DWKYLKDISP---------------------------------------------------------------------------------------------------------------Y---HQVSSSA---R------------------YPP-------------------------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FT-T-----STRDD--RVHP----------------GHARRM---------------------------VANLL----------SA-------------GHSR--V---HYYENIE-G----------------------------------GH----------------------------GGA-ADSRQR--------AFLNLLAYQFLYKTFE----- 72
73 PQYDASNLDVAQQIAVS-ND--GTE------------IPYFIIKNKDL--------KLDGKN------------PTLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FEVSLGPH-YIA-TAGLAWLERGGV-----Y----------------------------------------VE------A-N---IR-GG----GE-----FG-PSWHQ--A-ALKA-------NR-----------NKAYED--FIAV----------------------------------------------G-----------------------------E--HL-------------------------------------------------I-EAGIC-KPK--------------------------------------------------------T----L-AI--R-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LMGNMY-------------------------------------T------------------------------------------MRP-D-LWGAI--HCA------------------------------------------------------------------------------------------------------VPLL-------D---MKRY----------------------------------HTLLAGASWMAEYGD-PDT-D------------------------------------------------DWEFLQKFSP---------------------------------------------------------------------------------------------------------------Y---HNIDPTE---E------------------YPP-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-T-----STRDD--RVHP----------------GHARKF---------------------------VKKLW----------DD-------------GKGKWPV---YYYENIE-G----------------------------------GH----------------------------GGT-ADAKQS--------AFMTALAYDFMFDTL------ 73
74 -DFDVTGYQVSQHFVRS-RD--GTR------------VSYFQIAANNL--------RLDGST------------PTLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FSESLLPD-YLG-DEAPAWLERGGV-----Y----------------------------------------IV------A-N---IR-GG----GE-----YG-PAWHK--A-ALKQ-------NR-----------HRSFED--FAAV----------------------------------------------A-----------------------------E--DL-------------------------------------------------I-ARKVT-SPH--------------------------------------------------------H----L-GI--R-G--ES-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LTGNML-------------------------------------T------------------------------------------LYP-Q-LFGCI--VCG------------------------------------------------------------------------------------------------------VPLL-------D---MKRY----------------------------------THLSAGASWIAEFGD-PDKPE------------------------------------------------EWKFIRTFSP---------------------------------------------------------------------------------------------------------------Y---HNIKAEV---N------------------YPP-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FY-T-----ATSDD--RVNP----------------AHARKM---------------------------AARMQ----------AM-------------GHQ--QV---YFYENTK-G----------------------------------GH----------------------------NAA-ADKQQS--------AFISALVSEFMWSHL------ 74
75 -DFDVTGYQVSQHFVRS-RD--GTR------------VSYFQIAANNL--------RLDGST------------PTLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FSESLLPE-YLG-DEAPAWLKRGGV-----Y----------------------------------------VV------A-N---IR-GG----GE-----YG-PDWHK--A-ALKQ-------NR-----------HRSFED--FAAV----------------------------------------------A-----------------------------K--DL-------------------------------------------------I-ARKVT-SSH--------------------------------------------------------H----L-GI--R-G--ES-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LTGNML-------------------------------------T------------------------------------------LYP-H-LFGCI--VCG------------------------------------------------------------------------------------------------------VPLL-------D---MKRY----------------------------------TQLSAGASWIAEFGD-PDKPE------------------------------------------------EWDYIRTFSP---------------------------------------------------------------------------------------------------------------Y---HNIKAEE---N------------------YPP-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FY-T-----ATSDD--RVNP----------------AHARKM---------------------------AARMQ----------AM-------------GHQ--QV---YFYENTK-G----------------------------------GH----------------------------NAA-ADKQQA--------AFISALVSEFMW--------- 75
76 ---DKADFEVTQHFVQS-LD--GTY------------IPYFQIATKGL--------ELTGNH------------PTLLY----G-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FGVSLIPE-YMG-AKGATWLQKGGV-----Y----------------------------------------VV------A-N---IR-GG----GE-----YG-PEWHQ--A-ALQQ-------HR-----------HRAYED--FAAV----------------------------------------------A-----------------------------R--DL-------------------------------------------------V-TRGVT-CAA--------------------------------------------------------R----L-AA--Q-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LIGNML-------------------------------------T------------------------------------------DYP-A-LFGAL--LCE------------------------------------------------------------------------------------------------------VPLL-------D---MANY----------------------------------HRWLAGASWIAEYGD-PDIAE------------------------------------------------EWQWLQTYSP---------------------------------------------------------------------------------------------------------------F---DKVSSDV---I------------------YPP-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FT-T-----GTHDD--RVSP----------------AHARKM---------------------------VARMK----------QQ-------------GHN--NV---WLYEETN-A----------------------------------GH----------------------------GGA-QDNSQL----------------------------- 76
77 -TFTADGLVVTQHEAIS-ID--GER------------IPYVQ--TGPA--------KETGDA------------PVYMS----A-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FAVAVKPY-YNP-SLGKLWLERGGT-----T----------------------------------------VQ------A-N---LR-GG----GE-----FG-TRWHD--A-GRLA-------GK-----------KLSHDD--FAAV----------------------------------------------A-----------------------------A--DL-------------------------------------------------V-RRGVT-SAK--------------------------------------------------------R----I-AA--Q-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I-LITNML-------------------------------------V------------------------------------------RYP-E-RFGAL--FCT------------------------------------------------------------------------------------------------------IPLI-------D---MRRY----------------------------------TKLLAGASWIAEYGD-PDKPD------------------------------------------------EWEWLKTYSA---------------------------------------------------------------------------------------------------------------Y---HHAKPGQ---A------------------YPP-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IA-T-----TRRDD--RVHP----------------GHARKM---------------------------AAKLQ----------AM-------------GY---EA---WFYEPAA-G----------------------------------GH----------------------------GYG-KDNKER--------AGFEVLGFRFLRDKI------ 77
78 -TFTADGLVVTQHEAIS-ID--GER------------IPYVQ--TGPA--------KETGDA------------PVYMS----A-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------FAVAVKPY-YNA-SLGKLWLERGGT-----T----------------------------------------VQ------A-N---LR-GG----GE-----FG-TRWHD--A-GRLA-------GK-----------KLSHDD--FAAV----------------------------------------------A-----------------------------A--DL-------------------------------------------------V-RRGVT-SAK--------------------------------------------------------R----I-AA--Q-G--GS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I-LITNML-------------------------------------V------------------------------------------RYP-E-RFGAL--FCT------------------------------------------------------------------------------------------------------IPLI-------D---MRRY----------------------------------TKLLAGASWIAEYGD-PDKPD------------------------------------------------EWEWLKTYSA---------------------------------------------------------------------------------------------------------------Y---HNAKPGQ---A------------------YPP-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IA-T-----TRRDD--RVHP----------------GHARKM---------------------------AAKLQ----------AM-------------GY---EA---WFYEPAA-G----------------------------------GH----------------------------GYG-KDNKER--------AGFEVLGFRFLRDKI------ 78
79 SYPEYDNLEVKEVMATS-YD--GVK------------VPLSLIYNRGI--------RMDGKN------------PVLIY----G-------Y---------------------------------------------------------G--------------------A-----------------------------------------------------------YGNSMTPF-FNP-SFLLWTYK-GGI-----L----------------------------------------AV------A-H---VR-GG----GE-----LG-DAWHK--A-GMKS-------TK-----------PNTWKD--LIAC----------------------------------------------A-----------------------------E--YL-------------------------------------------------I-HEGYT-SPE--------------------------------------------------------H----I-AI--N-S--AS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I-LIGRAI-------------------------------------T------------------------------------------ERP-D-LFAAA--MPQ------------------------------------------------------------------------------------------------------VGVL-------N---AVRG----------------------------------EFSPNGPVNVPEFGTV-KNPE------------------------------------------------ECKALLEMDA---------------------------------------------------------------------------------------------------------------Y---LHIRDGV---K------------------YPA-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IT-A-----GMNDP--RVPA----------------WQPAKF---------------------------AARLQ----------EATTS-------------GKPV---LFFTDYK-A----------------------------------GH----------------------------GIG---DTKT------KQFESLADMLSFGLWQTGGAAQ- 79
80 -DFNENDYAEKRVWITV-RD--GER------------VPVSLVWRKNT---------VAKSQ------------AMFIT----A-------Y---------------------------------------------------------G--------------------A-----------------------------------------------------------YEISSDPY-FSV-ARLSMLDR-GVL-----F----------------------------------------VQ------V-H---VR-GG----GE-----MG-RAWYE--N-GRRR-------NK-----------KHTFED--FVDV----------------------------------------------T-----------------------------R--AL-------------------------------------------------Q-QAGYA-SAN--------------------------------------------------------Q----T-VA--N-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LMGAVA-------------------------------------N------------------------------------------MAP-Q-YYAGI--EAD------------------------------------------------------------------------------------------------------VPFV-------D---ALTS-------------------------------MLDDSLPLTVTEWDEWGDPLHNAQ------------------------------------------------DYAYLKSYTP---------------------------------------------------------------------------------------------------------------Y---ENVPEHVEPGE------------------FPK-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IT-S-----SINDT--RVLV----------------TEPLKW---------------------------LARLQ----------AA-GA------DA------------IARIETD-G----------------------------------GH----------------------------GGS---SGRY------KKWEEVCYENAWCLDAMG----- 80
81 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-----F----------------------------------------AI------A-H---IR-GG----GE-----LG-RAWYD--D-GKEA-------VK-----------VNTFTD--FIDV----------------------------------------------G-----------------------------R--WM-------------------------------------------------V-ESGWV-APG--------------------------------------------------------R----L-IA--E-G--RS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LMGAVL-------------------------------------N------------------------------------------MAP-D-LYRTV--IAG------------------------------------------------------------------------------------------------------VPFV-------D---ALTT-------------------------------ILDPSLPLTVGEWEEWGNPIENPE------------------------------------------------IFRIMKGYTP---------------------------------------------------------------------------------------------------------------Y---ENVPENV---A------------------LPA-------------------------VM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AT-T-----SVNDT--RVEF----------------VEPTKW---------------------------VQRLR----------EA-SG----QNTDADLATSRPI---VLRTQMV-A----------------------------------GH----------------------------AGP---SGRE------GRWKARAEEFAFALGQVG----- 81
82 ---DPSTMVEERVWVTA-RD--GKT-----------QIPVTLIHGVDV--------RPDGTN------------PGWEL----G-------Y---------------------------------------------------------G--------------------S-----------------------------------------------------------YEVSYDPE-FET-LRLPIFER-GVV-----F----------------------------------------AI------A-H---IR-GG----GE-----LG-RAWYD--D-GKEA-------VK-----------VNTFTD--FIDV----------------------------------------------G-----------------------------R--WM-------------------------------------------------V-ESGWV-APG--------------------------------------------------------R----L-IA--E-G--RS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LMGAVL-------------------------------------N------------------------------------------MAP-D-LYRTV--IAG------------------------------------------------------------------------------------------------------VPFV-------D---ALTT-------------------------------ILDPSLPLTVGEWEEWGNPIENPE------------------------------------------------IFRIMKGYTP---------------------------------------------------------------------------------------------------------------Y---ENVPENV---A------------------LPA-------------------------VM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AT-T-----SVNDT--RVEF----------------VEPTKW---------------------------VQRLR----------EA-SG----QNTDADLATSRPI---VLRTQMV-A----------------------------------GH----------------------------AGP---SGRE------GRWKARAEEFAFALGQVG----- 82
83 -GYDKKNYETERLFATA-KD--GTK------------IPISIVYKKGY--------KKDGKA------------PLLLY----A-------Y---------------------------------------------------------G--------------------S-----------------------------------------------------------YGSSMDAT-FSS-TRLSLLDR-GFA-----Y----------------------------------------AI------A-H---IR-GG----QE-----MG-RQWYE--D-GKMM-------KK-----------KNTFTD--FIDA----------------------------------------------G-----------------------------E--YL-------------------------------------------------V-NQKYT-SPK--------------------------------------------------------H----L-YA--Q-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LMGAIV-------------------------------------N------------------------------------------MKP-E-LWNGV--ISQ------------------------------------------------------------------------------------------------------VPFV-------D---VVNT-------------------------------MLDESIPLTTNEYDEWGNP-NNKE------------------------------------------------AYFYMKSYSP---------------------------------------------------------------------------------------------------------------Y---ENV-EKK---N------------------YPN-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-T-----GLHDS--QVQY----------------FEPAKW---------------------------VARLR----------DM-KT------DK------NVL---MLKTDMD-Y----------------------------------GH----------------------------GGA---SGRF------DYLKDVALVYAFMFKL------- 83
84 -GFYAANYRSEHLWIVA-RD--GVE------------VPVSLVYHRKH--------FRKGHN------------PLLVY----G-------Y---------------------------------------------------------G--------------------S-----------------------------------------------------------YGASIDAD-FSF-SRLSLLDR-GFV-----Y----------------------------------------AI------V-H---VR-GG----GE-----LG-QQWYE--D-GKFL-------KK-----------KNTFND--YLDA----------------------------------------------C-----------------------------D--AL-------------------------------------------------L-KLGYG-SPS--------------------------------------------------------L----C-YA--M-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-LMGVAI-------------------------------------N------------------------------------------QRP-E-LFHGV--IAQ------------------------------------------------------------------------------------------------------VPFV-------D---VVTT-------------------------------MLDESIPLTTGEFEEWGNP-QDPQ------------------------------------------------YYEYMKSYSP---------------------------------------------------------------------------------------------------------------Y---DNV-TAQ---A------------------YPH-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-T-----GLHDS--QVQY----------------WEPAKW---------------------------VAKLR----------EL-KT------DD------HLL---LLCTDMD-S----------------------------------GH----------------------------GGK---SGRF------KSYEGVAMEYAFLVALAQGTLPA 84
85 GGFDRTLYTSERIFAQA-SD--GVE------------VPISLVYRKDS--------FERGKN------------PLWVY----G-------Y---------------------------------------------------------G--------------------S-----------------------------------------------------------YGYPLPMG-FNS-NRLSLLDR-GFV-----L----------------------------------------AY------A-H---IR-GG----GD-----MG-KPWHD--A-GRLI-------HK-----------RNTFTD--FIAV----------------------------------------------T-----------------------------E--HL-------------------------------------------------A-AHGYG-DPA--------------------------------------------------------R----I-AA--E-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LMGAIV-------------------------------------N------------------------------------------LRP-D-LYRAI--VSH------------------------------------------------------------------------------------------------------VPFV-------D---VMNT-------------------------------MLDASLPLTVPEYEEWGNP-NEPE------------------------------------------------AFEYMLSYSP---------------------------------------------------------------------------------------------------------------Y---DNL-KAA---S------------------YPA-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VK-T-----SLNDS--QVMY----------------WEPAKY---------------------------VAKLR----------TL-KQ------DN------HLL---LLHTNMS-A----------------------------------GH----------------------------GGA---SGRY------DYLKEIAFDYAFLLRELGI---- 85
86 -GYDRSMYRTARIMAQA-RD--GEQ------------VAVSLVFHKDC-----AWAKSRSPS------------PMMLY----G-------Y---------------------------------------------------------G--------------------S-----------------------------------------------------------YGICIDPS-FDS-KTISFLDR-GMI-----Y----------------------------------------AI------A-H---IR-GG----GE-----MG-RQWYE--EQGKFL-------TK-----------MNTFTD--FCDC----------------------------------------------A-----------------------------E--HL-------------------------------------------------I-KLGMT-TSS--------------------------------------------------------R----L-AI--S-G--RS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LMGAVM-------------------------------------N------------------------------------------LRP-D-LFRVV--VAG------------------------------------------------------------------------------------------------------VPFV-------D---IMAT-------------------------------MSDPSIPLTITEWEEWGNP-NERR------------------------------------------------FFDYMLSYSP---------------------------------------------------------------------------------------------------------------V---DNI-RDA---H------------------YPA-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-A-----GLNDP--RVPY----------------WEPAKW---------------------------VARLR----------EK-NK------SK------KPM---LLRTDMS-S----------------------------------GH----------------------------FAA---SDRY------RLMAERSIEFAFVVDQLE----- 86
87 -GYDRSMYECERTVANA-RD--GVE------------VPMSIVYRKDAYPDGLAGAK----A------------PCMLY----G-------Y---------------------------------------------------------G--------------------S-----------------------------------------------------------YGASMEPS-FDF-TRLSFLDR-GMV-----Y----------------------------------------AI------A-H---IR-GG----GE-----MG-RPWYE--DSGKYL-------TK-----------RNTFQD--FVDC----------------------------------------------A-----------------------------E--HL-------------------------------------------------V-AEGVT-SPK--------------------------------------------------------G----L-AV--C-G--RS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LIGNVV-------------------------------------N------------------------------------------MRP-D-LFAAA--VAD------------------------------------------------------------------------------------------------------VPFV-------D---LMNSRAAAGAGSWRGSLARDRVLMTEKKLDLEYIQMADPSIPLTITEWEEWGNP-NESK------------------------------------------------YHDYMLSYSP---------------------------------------------------------------------------------------------------------------Y---DNV-RRQ---P------------------YPA-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-G-----GLNDP--RVAY----------------WEPCKW---------------------------VSKLR----------DM-AT------TD------NPL---YLKIDMS-A----------------------------------GH----------------------------FSA---SDRY------KHMKEQAFEYAFVL--------- 87
88 -NYDRSFYKTERLEAKA-SD--GTM------------VPISLVYRSDL--------RSQNRQ------------PLHLY----G-------Y---------------------------------------------------------G--------------------S-----------------------------------------------------------YEIPIDPS-FVS-SILPLLDR-GVI-----Y----------------------------------------AI------A-H---IR-GG----GE-----MG-RTWYE--DA-KYK-------KK-----------INTFTD--FISC----------------------------------------------A-----------------------------E--HL-------------------------------------------------V-NAGYT-SPS--------------------------------------------------------K----M-TC--E-G--RS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LMGAVL-------------------------------------N------------------------------------------MRP-D-LFTAA--IAG------------------------------------------------------------------------------------------------------VPFV-------D---VMNT-------------------------------MSDASIPLTTGEWEEWGNP-NEKA------------------------------------------------YFEYMLSYSP---------------------------------------------------------------------------------------------------------------Y---ENV-KQQ---A------------------YPN-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-S-----GLFDP--RVAY----------------WEPTKW---------------------------VAKLR----------DM-KS------DQ------NEV---LLKMDLS-S----------------------------------GH----------------------------FSA---SDRY------HYLKEKAFDMAYLL--------- 88
89 -GFDASNYVSERKWAAA-SD--GTQ------------IPISILYRKDL-------VKLDGSD------------PMLLY----G-------F---------------------------------------------------------G--------------------S-----------------------------------------------------------YEVCVDPS-FSG-SIFSLADR-GFV-----Y----------------------------------------AI------A-H---VR-GG----GE-----MG-RKWYE--D-GKLL-------KK-----------KNTFTD--FIAC----------------------------------------------T-----------------------------E--HL-------------------------------------------------I-QSKYS-SKE--------------------------------------------------------K----I-CI--N-G--KS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LIGAVL-------------------------------------N------------------------------------------MRP-D-LFKAA--VVG------------------------------------------------------------------------------------------------------VPFV-------D---VLTT-------------------------------MLDPTIPLTTAEWEEWGDP-RKEE------------------------------------------------YYFYMKSYSP---------------------------------------------------------------------------------------------------------------V---DNV-KAQ---E------------------YPH-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-A-----GLNDP--CVMY----------------SEPAKF---------------------------VAKLR----------EL-KT------GD------NLV---LFKCELG-A----------------------------------GH----------------------------NSK---SGRF------EKLREDAFAYAFIL--------- 89
90 -GFDASNYVTERKWAAA-SD--GTQ------------IPMSILYRKDM-------VNLDGSD------------PMLLY----G-------Y---------------------------------------------------------G--------------------S-----------------------------------------------------------YEICIDPT-FRG-SRFSLVDR-GFI-----Y----------------------------------------VI------A-H---IR-GG----GE-----MG-RKWYE--D-GKLL-------KK-----------KNTFTD--FISC----------------------------------------------A-----------------------------E--HL-------------------------------------------------I-ENKYC-TKE--------------------------------------------------------K----L-CI--N-G--RS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LMGAVL-------------------------------------N------------------------------------------MRP-D-LFKAA--VAG------------------------------------------------------------------------------------------------------VPFV-------D---VLTT-------------------------------MLDPTIPLTTAEWEEWGDP-RKEE------------------------------------------------YYYYMKSYSP---------------------------------------------------------------------------------------------------------------V---DNV-KAQ---Q------------------YPH-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-A-----GLNDP--RVMY----------------SEPAKF---------------------------VARLR----------EL-KT------DE------NLL---LFKCELG-A----------------------------------GH----------------------------FSK---SGRF------EKLREDAFTYAFILKALGM---- 90
91 -GFDASNYVTERKWVAA-SD--GTQ------------IPMSIVYNKKL-------AKLDGSD------------PLLLY----G-------Y---------------------------------------------------------G--------------------S-----------------------------------------------------------YEISVDPY-FKA-SRLSLLDR-GFT-----F----------------------------------------VI------A-H---VR-GG----GE-----MG-RQWYE--N-GKLL-------KK-----------KNTFTD--FIAC----------------------------------------------A-----------------------------E--RL-------------------------------------------------I-ELKYC-SKE--------------------------------------------------------K----L-CM--E-G--RS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LMGAVV-------------------------------------N------------------------------------------MRP-D-LFKVV--IAG------------------------------------------------------------------------------------------------------VPFV-------D---VLTT-------------------------------MLDPTIPLTTSEWEEWGDP-RKEE------------------------------------------------FYFYMKSYSP---------------------------------------------------------------------------------------------------------------V---DNV-TAQ---N------------------YPN-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-A-----GLNDP--RVMY----------------SEPGKW---------------------------VAKLR----------EM-KT------DN------NVL---LFKCELG-A----------------------------------GH----------------------------FSK---SGRF------EKLQEDAFTFAFMMKVLDMIPAS 91
92 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WYE--D-GKLQ-------KK-----------ANTFTD--FIAA----------------------------------------------A-----------------------------E--HL-------------------------------------------------ITSAKLV-TPQ--------------------------------------------------------R----L-CI--E-G--RS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LMGAVL-------------------------------------N------------------------------------------MRP-D-LFHAA--IIG------------------------------------------------------------------------------------------------------VGFV-------D---ALTT-------------------------------MLDDTIPLTIIEREEWGDPAADAA------------------------------------------------VYAYMKSYSP---------------------------------------------------------------------------------------------------------------V---DNV-RAQ---R------------------YPH-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AI-A-----GLHDP--RVGY----------------WEPAKF---------------------------VAKLR----------EH-KT------DR------NLL---LLKTEMG-A----------------------------------GH----------------------------FSV---TGRF------ERLKEVAFEFAFLFKVLGMM--- 92
93 SGYDPSLYVSERLWVSA-PD--GVQ------------VPMSIVYRRD---------RPRNGG------------PCLLV----G-------Y---------------------------------------------------------G--------------------A-----------------------------------------------------------YGYSYDPA-FDS-KRLSLLDR-GFV-----V----------------------------------------AI------A-H---IR-GG----QE-----LG-RQWYE--Q-GRML-------HK-----------PNTFSD--FIAC----------------------------------------------A-----------------------------E--HL-------------------------------------------------I-NEGYT-SPS--------------------------------------------------------H----L-AI--S-G--RS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LMSAVV-------------------------------------N------------------------------------------ARP-D-LFQAV--VAG------------------------------------------------------------------------------------------------------VPFT-------N---VIIA-------------------------------MLKPDLPLTATEWEQWGNP-AIEE------------------------------------------------EYRVMRSYDP---------------------------------------------------------------------------------------------------------------Y---LNL-KPG---A------------------YPH-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AT-A-----GLHDL--QVPY----------------WDPAKW---------------------------VAKLR----------TV-KT------ND------TML---LLRTNLQ-A----------------------------------GH----------------------------SGH---SGRF------ARLEEFAWEYAFILTALGIHA-- 93
94 GEFDSSLYTLERIYVPI-PE--TTKTEAPFNTPTPETIPVSIMYRKDL-------FKKDGTN------------PLHLY----G-------Y---------------------------------------------------------G--------------------S-----------------------------------------------------------YGISIPTA-YSA-IQFPILDR-GYV-----Y----------------------------------------AI------A-H---IR-GG----GS-----CG-KAWYE--T-GKFK-------SK-----------RNTFTD--FIAC----------------------------------------------S-----------------------------Q--EL-------------------------------------------------V-KLQYT-QHE--------------------------------------------------------L----M-SI--E-G--RS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LMGAVV-------------------------------------N------------------------------------------MKP-D-IAHVV--IAG------------------------------------------------------------------------------------------------------VPFV-------D---VINT-------------------------------MMDPTIPLTINEYEEWGNP-NDKE------------------------------------------------YFEYMRSYSP---------------------------------------------------------------------------------------------------------------Y---DNIPSDK---Q------------------FPN-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VK-A-----GLNDP--RVAY----------------WEPAKW---------------------------VAKMR----------AL-DV----CRGK------TQI---LLHCTMG-A----------------------------------GH----------------------------FGV---SGRY------ARYMEVASDFAFLVECM------ 94
95 -GYDKELYACERTTVKS-RD--GSV-----------DIPVSLVYRKDV---MEDHLQSGKAV------------HTHLY----G-------Y---------------------------------------------------------G--------------------S-----------------------------------------------------------YGACIEAD-FRS-TRLPLLNR-GVI-----Y----------------------------------------VI------A-H---IR-GG----GE-----MG-RKWYEEPNGAKYL-------CK-----------KNTFDD--FVDV----------------------------------------------A-----------------------------K--WL-------------------------------------------------ISDRKLT-SPD--------------------------------------------------------V----L-SC--E-G--RS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LIGSSI-------------------------------------N------------------------------------------QAP-E-LFQMA--ILG------------------------------------------------------------------------------------------------------VPFV-------D---VLCT-------------------------------MVDASIPLTAVEWEEWGNP-NEEK------------------------------------------------YHQYMKEYCP---------------------------------------------------------------------------------------------------------------V---QNV-KKA---R------------------YPS-------------------------CL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LT-G-----GLHDP--RVQY----------------WEPSKF---------------------------AATLR----------HT-QS------NE-----SGPV---CVKMDMS-A----------------------------------GH----------------------------FSA---SDRY------KYLKELAFDYAFLL--------- 95
96 --HNASDYVTTRIMAKA-QD--GAE------------VPVSILHRHGL--------KLDGSA------------PLLLY----G-------Y---------------------------------------------------------G--------------------S-----------------------------------------------------------YGMAMPAS-FNA-NRLSLVDR-GFV-----Y----------------------------------------AI------A-H---IR-GG----AD-----KG-WGWYL--D-GKRE-------KK-----------TNSFDD--FAAS----------------------------------------------A-----------------------------R--AL-------------------------------------------------I-DAKYT-SAR--------------------------------------------------------R----I-VG--H-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-LMGAVA-------------------------------------N------------------------------------------RAG-E-LFAGI--VAE------------------------------------------------------------------------------------------------------VPFV-------D---VLNT-------------------------------MLDDTLPLTPPEWPEWGNPIESEK------------------------------------------------DFRTILSYSP---------------------------------------------------------------------------------------------------------------Y---DNV-AAK---A------------------YPA-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AM-G-----GLTDP--RVTY----------------WEPAKW---------------------------IARLR----------AT-MR------GG------GPV---LLRTNMG-A----------------------------------GH----------------------------GGA---SGRF------DRLDEVAIVYAFALWAAGM---- 96
97 --HNASDYVTTRIMAKA-QD--GAE------------VPVSILHRHGL--------KLDGSA------------PLLLY----G-------Y---------------------------------------------------------G--------------------S-----------------------------------------------------------YGMAMPAS-FNA-NRLSLVDR-GFV-----Y----------------------------------------AI------A-H---IR-GG----AD-----KG-WGWYL--D-GKRE-------KK-----------TNSFDD--FAAS----------------------------------------------A-----------------------------R--AL-------------------------------------------------I-DAKYT-SAK--------------------------------------------------------R----I-VG--H-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-LMGAVA-------------------------------------N------------------------------------------RAG-E-LFAGI--VAE------------------------------------------------------------------------------------------------------VPFV-------D---VLNT-------------------------------MLDDTLPLTPPEWPEWGNPIESEK------------------------------------------------DFRTILSYSP---------------------------------------------------------------------------------------------------------------Y---DNV-AAK---A------------------YPA-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AM-G-----GLTDP--RVTY----------------WEPAKW---------------------------IARLR----------AT-MR------GG------GPV---LLRTNMG-A----------------------------------GH----------------------------GGA---SGRF------DRLDEVAIVYAFALWAAGM---- 97
98 SGFDAEEYKVERIFADS-EE---VK------------IPVTLLYKKSL-------FKKDGTN------------PVYLY----G-------Y---------------------------------------------------------G--------------------S-----------------------------------------------------------YGYAVPVS-FKN-NAISLVNR-GFV-----Y----------------------------------------VI------A-H---IR-GG----DD-----LG-FYWYE--S-AKFL-------NK-----------KRTFLD--FIAA----------------------------------------------S-----------------------------E--AL-------------------------------------------------I-RENYT-SEN--------------------------------------------------------N----I-VI--C-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LIGAVI-------------------------------------N------------------------------------------ERP-E-LFKAA--IAH------------------------------------------------------------------------------------------------------VPFV-------D---VLNT-------------------------------MLDESLPLTPGEFKEWGNPKEPE-------------------------------------------------FFSYIKSYSP---------------------------------------------------------------------------------------------------------------Y---DNV-KSQ---N------------------YPS-------------------------LY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-A-----GLSDP--RVSY----------------WEAAKW---------------------------VAKLR----------EK-KS------DS------NIL---LLKTNMD-S----------------------------------GH----------------------------YGA---SGRF------DYLKEAADDIVFIISVFGI---- 98
99 -------YVTKILWVPS-KSDPSIK------------IPLSIAYHKD--------LKLDGKN------------PCILH----G-------Y---------------------------------------------------------G--------------------S-----------------------------------------------------------YGNINELT-HSL-EDIFFLNG-GMI-----V----------------------------------------AK------A-H---VR-GG----GE-----LG-RAWYK--D-GKLL-------NK-----------KNSFKD--YIDC----------------------------------------------V-----------------------------E--YL-------------------------------------------------F-EHGYT-SPE--------------------------------------------------------Y----L-IG--K-G--SS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LMCNVS-------------------------------------L------------------------------------------THP-H-YFSAI--ISR------------------------------------------------------------------------------------------------------VPFV-------D---IITA-------------------------------MMDEELPLTIHEFDEWGNVNKDKE------------------------------------------------AFEYIKEYDP---------------------------------------------------------------------------------------------------------------YLLIDTFDV-SKFKS------------------FPD-------------------------LY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-G-----SSSDF--RVPF----------------WQPLKW---------------------------VAKLR----------NYFNN--YNNNNNNNNNIKPLI---FLNIDDG-S----------------------------------GH----------------------------FGP---NDRD------SLIINFSKEISFI---------- 99
100 -------FETDILWVPS-KSDPSIK------------IPLSICYNKKA-------VRFDGKT------------PCVLH----G-------Y---------------------------------------------------------G--------------------S-----------------------------------------------------------YGTVYSLL-YNV-EDLLLMNA-GFI-----V----------------------------------------AR------A-H---VR-GG----SE-----LG-RTWYN--D-GKLL-------NK-----------KNTFSD--YIDC----------------------------------------------V-----------------------------E--YL-------------------------------------------------F-ENKYT-SPN--------------------------------------------------------Y----L-IG--R-G--SS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LMCNVA-------------------------------------L------------------------------------------TYP-H-YFSGI--ISQ------------------------------------------------------------------------------------------------------VPFA-------D---VLTS-------------------------------MLDESLPLTIHEYGEWGNPNLDKQ------------------------------------------------VFNYIKQYDP---------------------------------------------------------------------------------------------------------------YILLDDPNIQSSLKS------------------LPN-------------------------LY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IT-C-----STSDY--RVPF----------------WQPLKW---------------------------VAKLR----------NKLKSLTHGDDNNNNNNNSPLI---LLGIDDD-S----------------------------------GH----------------------------FGP---NDRN------SLTKKWSFDLSFI---------- 100
101 -----------------------------------------------------------------------------LL----A-------Y---------------------------------------------------------G--------------------A-----------------------------------------------------------YGSFHETG-FSE-DFFPLVDR-GVL-----I----------------------------------------AI------C-H---PR-GD----GD-----MG-SQWYK--D-GKYE-------AK-----------INTMSD--TRKC----------------------------------------------I-----------------------------Q--EL-------------------------------------------------V-KLGYS-KPG--------------------------------------------------------A----I-AL--K-A--RS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-IAGSAIS-----W--------------IW-------------ED------------------------------------------QTP---MVNAI--VAQ------------------------------------------------------------------------------------------------------VPFV-------D---PIFD-------------------------------MLDESVPWTAFEWFEWGSP-KNYT------------------------------------------------IFKAMMQYSP---------------------------------------------------------------------------------------------------------------Y---LNI-KSG---N------------------HPA-------------------------VM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-A-----GMEDP--RVPF----------------WEPAKF---------------------------VAKLR----------TY-KTNEISIGSNYLTSEATPL---LFRV-YS-T----------------------------------GH----------------------------FSS---MDED------ARIKELTEWYSFLL--------- 101
102 WSDLSKLFSCERVQVIS-HD--GVS------------IPLMILYSQEE--------HIHGES------------PGILY----G-------Y---------------------------------------------------------G--------------------A-----------------------------------------------------------YGEDLDKG-WCS-DRLSLLAR-GWV-----L----------------------------------------AF------A-D---VR-GG-----------GD-PSWHL--A-GTKS-------NK-----------INSVKD--FAAC----------------------------------------------G-----------------------------M--HL-------------------------------------------------I-KEGFV-HER--------------------------------------------------------R----L-CA--V-G--CS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVGAVI-------------------------------------N------------------------------------------MLP-N-LLSAA--VLK------------------------------------------------------------------------------------------------------VPFL-------D---TCNT-------------------------------MLDPTLPLTILDYEEFGDP-NIPV------------------------------------------------EFDVIQSYSP---------------------------------------------------------------------------------------------------------------Y---DNISGGV---C------------------YPS-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-A-----SFNDT--RVGV----------------WEAAKW---------------------------VSKVR----------DV-TC----PSCS------QSV---VLKTNMQ-S----------------------------------GH----------------------------FGE---GGRL------MSCEETAFEYAFIMKALG----- 102
103 WEDLSDTYVCERQEVSS-HD--GVE------------VPLTILYSREA--------WKKSES------------PGMLI----G-------Y---------------------------------------------------------G--------------------A-----------------------------------------------------------YGEVLDKS-WCT-NRLSMLDR-GWV-----I----------------------------------------AF------A-D---VR-GG----GS-----GE-FSWHK--S-GTRS-------LK-----------QNSIQD--FIYS----------------------------------------------A-----------------------------K--YL-------------------------------------------------V-EKGYV-HRH--------------------------------------------------------H----L-AA--V-G--YS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I-LPAAAM-------------------------------------N------------------------------------------MHP-S-LFQAV--ILK------------------------------------------------------------------------------------------------------VPFV-------D---VLNT-------------------------------LSDPNLPLTLLDHEEFGNP-DNQT------------------------------------------------DFGSILSYSP---------------------------------------------------------------------------------------------------------------Y---DKIRKDV---C------------------YPS-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-T-----SFHDS--RVGV----------------WEGAKW---------------------------VAKIR----------DS-TC----HDCS------RAV---ILKTNMN-G----------------------------------GH----------------------------FGE---GGRY------AQCEETAFDYAFLLKVMGHHNNR 103
104 ------NFVIEKQTIPS-RD--GTC-----------NIPITILKNKNI--------SHSPSN------------PCVIL----V-------Y---------------------------------------------------------G--------------------S-----------------------------------------------------------YGYCIETS-FRV-ELLPALSR-GVT-----V----------------------------------------VF------A-H---VR-GG----GE-----LG-NSWYH--K-GRAE-------NK-----------LCSFTD--LEDV----------------------------------------------A-----------------------------D--ML-------------------------------------------------I-YKKYT-SSE--------------------------------------------------------R----L-GG--I-G--TS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-LLA---------------------------------------------------------------------------------------D-LFKAL--VLR------------------------------------------------------------------------------------------------------VSFL-------D---PLTT-------------------------------MLDPNSSLSAGEVLEWGNPLKDSA------------------------------------------------AYQLMSSYSP---------------------------------------------------------------------------------------------------------------Y---DNLDGKL----------------------RTA-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AT-A-----GSDDQ--RVPP----------------WHALKY---------------------------IVRMH----------EL-AQHSGTASNG------------YFKLYAD-R----------------------------------GH----------------------------NQG---SG--------DNIDEHAFEYAFLLS-------- 104
105 ---KPEDYACQRLVAQS-QD--GTN------------VPITVFHRENL--------VLDGQH------------PMLVI----G-------Y---------------------------------------------------------G--------------------A-----------------------------------------------------------YGRNVEME-YTA-ERMALLSN-GWV-----L----------------------------------------AF------C-H---VR-GG----GE-----LG-KEWYY--S-GKGD-------QK-----------HHSFED--LESC----------------------------------------------V-----------------------------E--FL-------------------------------------------------H-SSGFS-RPA--------------------------------------------------------L----T-AG--W-A--AS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LLGVLC-------------------------------------N------------------------------------------RSP-H-LLRAA--VMR------------------------------------------------------------------------------------------------------MPFV-------D---ILSS-------------------------------MLDSTSPLTSQDIEEWGDPSGSAA------------------------------------------------DMEYISAYCP---------------------------------------------------------------------------------------------------------------Y---HNL-RSQ---S------------------YPS-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-S-----SMTDQ--RVPS----------------WVPAKY---------------------------MARLR-------------DR----TRDHHHEHHRPTF---LLRVHSD-G----------------------------------GH----------------------------FG------------------------------------- 105
106 -------YACQRLVAQS-QD--GTN------------VPITVFHRENL--------VLDGQH------------PMLVI----G-------Y---------------------------------------------------------G--------------------A-----------------------------------------------------------YGRNVEME-YTA-ERMALLSN-GWV-----L----------------------------------------AF------C-H---VR-GG----GE-----LG-KEWYY--S-GKGD-------QK-----------HHSFED--LESC----------------------------------------------V-----------------------------E--FL-------------------------------------------------H-SSGFS-RPA--------------------------------------------------------L----T-AG--W-A--AS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LLGVLC-------------------------------------N------------------------------------------RSP-H-LLRAA--VMR------------------------------------------------------------------------------------------------------MPFV-------D---ILSS-------------------------------MLDSTSPLTSQDIEEWGDPSGSAA------------------------------------------------DMEYISAYCP---------------------------------------------------------------------------------------------------------------Y---HNL-RSQ---S------------------YPS-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-S-----SMTDQ--RVPS----------------WVPAKY---------------------------MARLR-------------DR----TRDHHHEHHRPTF---LLRVHSD-G----------------------------------GH----------------------------FG------------------------------------- 106
107 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-GG----GE-----MG-RQWYR--E-GRLN-------KK-----------HKSFED--VEAC----------------------------------------------L-----------------------------K--HL-------------------------------------------------H-DAGYS-CAG--------------------------------------------------------K----T-AV--C-G--TS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LMATVC-------------------------------------N------------------------------------------RSP-H-LIKAA--VLK------------------------------------------------------------------------------------------------------VPFV-------D---VLNT-------------------------------MLDPMQPLTSQEYEEFGNPLDDRN------------------------------------------------ILDYIDSYCP---------------------------------------------------------------------------------------------------------------Y---QNI-TDQ---E------------------YPS-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LT-A-----SMNDT--RVPY----------------WMPLKY---------------------------TAKRR--------------H----YLNQTNSNKQDTL---LLQV-TG-N----------------------------------GH----------------------------FDD---DDLY---------EQTALEFGFL---------- 107
108 SSFEPGQYVCERCYVPS-MSSLGVK------------IPLTLIHRRDI--------SLNGQN------------PTLLI----G-------Y---------------------------------------------------------G--------------------A-----------------------------------------------------------YGSNLEAD-FEL-EHLSLLER-GWV-----I----------------------------------------AL------A-H---VR-GG----GE-----LG-LQWYQ--A-GKGM-------QK-----------RQSFDD--YVSC----------------------------------------------T-----------------------------H--HL-------------------------------------------------L-DAGFT-NPK--------------------------------------------------------R----L-AG--K-G--VS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-IMGYVA-------------------------------------N------------------------------------------EYP-Q-LYQAL--VMK------------------------------------------------------------------------------------------------------VPFV-------D---ILAT-------------------------------MQDPTLPLTVHEYDEWGDP-TGPK------------------------------------------------VLEYIQSYAP---------------------------------------------------------------------------------------------------------------C---DNVREHQ---V------------------YPA-------------------------MF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-G-----SLNDQ--RVQF----------------WEPTKW---------------------------MYKVR----------KV--Q------ASLPKRDKRLM---LLKMSED-E----------------------------------GH----------------------------FGG---GGRL------EQLEESAMEMAFL---------- 108
109 -------------------------------------VPLTIVHRRGI--------ELDGKN------------RLLLH----G-------Y---------------------------------------------------------G--------------------S-----------------------------------------------------------YGMSLPID-YHP-AQACMLER-GWV-----L----------------------------------------AF------A-H---VR-GG----GE-----RG-KAWHA--G-GRGL-------DK-----------WNSFWD--FEAC----------------------------------------------A-----------------------------E--HL-------------------------------------------------V-SGGFT-SPS--------------------------------------------------------L----M-GA--Q-V--NS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LAGVMA-------------------------------------N------------------------------------------QRP-G-LFSAM--VMK------------------------------------------------------------------------------------------------------APFL-------G---VLSA-------------------------------MRDSSLPLTVHEFDEWGDPNSSAE------------------------------------------------VESMIRSYCP---------------------------------------------------------------------------------------------------------------Y---ENVVEQE----------------------YPA-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-A-----SLNDK--RVNV----------------WDPAKW---------------------------VSRVR----------AA-NT------GQSP------V---LLRVSES-D----------------------------------GH----------------------------HGP---GNTL------DGLKDSALEMAFL---------- 109
110 -GLDSDQYSFYISHATS-KD--GCK------------IPISLCHRKDI--------VLNSST------------PLLAI----V-------Y---------------------------------------------------------G--------------------A-----------------------------------------------------------YGMELNRQ-FSV-QNMCLLKA-GWV-----L----------------------------------------AF------C-H---VR-GG----GE-----FG-RHWYY--Q-GRQL-------NK-----------MNSFYD--FLAC----------------------------------------------I-----------------------------N--EV-------------------------------------------------Q-DQGYT-KPT--------------------------------------------------------L----T-SC--K-G--TS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-IVAHLC-------------------------------------N------------------------------------------NHP-N-KIAAA--IMK------------------------------------------------------------------------------------------------------VPHV-------D---ILGT-------------------------------MLDQSLPLTVEEYEEWGDL-NSSH------------------------------------------------VFDYICSYCP---------------------------------------------------------------------------------------------------------------Y---TNIQRNL----------------------YPS-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LT-A-----SYNDN--RVPY----------------WSPVRF---------------------------MAKLR----------AAQRD----YQSQHEGATTNNKIYHILKTNLS-S----------------------------------GH----------------------------YGT---AGD-------EGLKEAAFEIAFL---------- 110
111 -----EGYDCKLELAES-WD--GVQ------------VPMTVIRRKGL--------PEDGSS------------PTLAF----V-------Y---------------------------------------------------------G--------------------S-----------------------------------------------------------YGQCLATE-FDV-GRISLLER-GWA-----I----------------------------------------VL------C-H---VR-GG----GE-----LG-SRWHR--E-GRGM-------KK-----------LNGFKD--LFAC----------------------------------------------M--------------------------------TW-------------------------------------------------I-GRRLS-RPG--------------------------------------------------------L----I-AL--H-G--TS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVSGYT-------------------------------------N------------------------------------------LYP-G-TVGAV--VAK------------------------------------------------------------------------------------------------------VPFV-------D---IGST-------------------------------MRDEDLSLTVHEYDEWGDM-RRTE------------------------------------------------VADYVDSYCP---------------------------------------------------------------------------------------------------------------Y---RNVSGVR----------------------YPP-------------------------IY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LT-A-----ALNDT--RVGY----------------WEPAKW---------------------------AAKVR----------HEGGE------GSGP------V---LLQTAFE-G----------------------------------GH----------------------------FGT---GGKT------GYLQDQAREAAFLYLALG----- 111
112 --------HTIRLEAKS-KD--GTW------------VPITVFHAASS--------IELCRR------------PLLIH----V-------Y---------------------------------------------------------G--------------------A-----------------------------------------------------------YGIDLNMS-FKA-ENLMLIND-GWI-----L----------------------------------------AF------C-H---VR-GG----GE-----LG-LGWHK--D-GCLK-------KK-----------HNGIQD--LQAC----------------------------------------------I-----------------------------R--LL-------------------------------------------------H-ELGYS-NPA--------------------------------------------------------R----T-AL--R-S--LS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-IAGALY-------------------------------------N------------------------------------------NDP-H-LIRAM--ALQ------------------------------------------------------------------------------------------------------APFL-------D---VLNT-------------------------------MLDPHLPLTIEEQEEWGNPLIDES------------------------------------------------YKEYIKNYCP---------------------------------------------------------------------------------------------------------------Y---QNI-RPQ---N------------------YPS-------------------------LF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IT-V-----SENDQ--RVPL----------------AGLLRF---------------------------ICKLR----------KAVQNNAQLNSTDDKGLQAPNI---ILDVQSG-G----------------------------------SH----------------------------CAP-SWEE---------SLNQVAAQLAFLYNEL------ 112
113 --------HTTRLLAKS-KD--ETL------------VPITVFHNVNS--------KELHRK------------PLLVH----V-------Y---------------------------------------------------------G--------------------A-----------------------------------------------------------YGIDLNMS-FKE-EKLMLIEE-GWI-----L----------------------------------------AY------C-H---VR-GG----GE-----LG-LRWHK--D-GCQQ-------NK-----------LKGLHD--LKAC----------------------------------------------I-----------------------------M--LL-------------------------------------------------H-ELGFS-QPK--------------------------------------------------------Y----T-AL--T-A--VS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-LAGAIC-------------------------------------N------------------------------------------SDP-E-LIRAV--VLQ------------------------------------------------------------------------------------------------------APFV-------D---VLNT-------------------------------MMKTHLPLSIEEQEEWGNPLADEK------------------------------------------------CMKYIKNYCP---------------------------------------------------------------------------------------------------------------Y---HNI-KPQ---C------------------YPS-------------------------VF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IT-A-----YENDQ--RVPL----------------TGILRY---------------------------VQKLR----------KATLDHA--SRTRKKGNWIPNI---ILDIQAS-G----------------------------------SH----------------------------CDS-SWED---------SLNEVARHLAFLKKELQV---- 113
114 --------RVLRLEAKS-KD--GKL------------VPMTVFHKTDS--------EDLQKK------------PLLVH----V-------Y---------------------------------------------------------G--------------------A-----------------------------------------------------------YGMDLKMN-FRP-ERRVLVDD-GWI-----L----------------------------------------AY------C-H---VR-GG----GE-----LG-LQWHA--D-GRLT-------KK-----------LNGLAD--LEAC----------------------------------------------I-----------------------------K--TL-------------------------------------------------H-GQGFS-QPS--------------------------------------------------------L----T-TL--T-A--FS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-LVGALC-------------------------------------N------------------------------------------SSP-E-LLRAV--TLE------------------------------------------------------------------------------------------------------APFL-------D---VLNT-------------------------------MMDTTLPLTLEELEEWGNPSSDEK------------------------------------------------HKNYIKRYCP---------------------------------------------------------------------------------------------------------------Y---QNI-KPQ---H------------------YPS-------------------------IH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IT-A-----YENDE--RVPL----------------KGIVNY---------------------------TEKLK----------EAIMEHA---KDPSEGYQTPNI---ILDIQPG-G----------------------------------NH----------------------------VI----ED---------SHKKITAQIKFLYEELGLDSTS 114
115 --------RVLRLEAKS-KD--GKL------------VPMTVFHKTDS--------EDLQKK------------PLLVH----V-------Y---------------------------------------------------------G--------------------A-----------------------------------------------------------YGMDLKMN-FRP-ERRVLVDD-GWI-----L----------------------------------------AY------C-H---VR-GG----GE-----LG-LQWHA--D-GRLT-------KK-----------LNGLAD--LEAC----------------------------------------------I-----------------------------K--TL-------------------------------------------------H-GQGFS-QPS--------------------------------------------------------L----T-TL--T-A--FS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-LAGALC-------------------------------------N------------------------------------------SNP-E-LVRAV--TLE------------------------------------------------------------------------------------------------------APFL-------D---VLNT-------------------------------MMDTTLPLTLEELEEWGNPSSDEK------------------------------------------------HKNYIKRYCP---------------------------------------------------------------------------------------------------------------Y---QNI-KPQ---H------------------YPS-------------------------IH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IT-A-----YENDE--RVPL----------------KGIVSY---------------------------TEKLK----------EAIAEHA---KDTGEGYQTPNI---ILDIQPG-G----------------------------------NH----------------------------VI----ED---------SHKKITAQIKFLYEELGLDSTS 115
116 --------RVLRLEAKS-KD--GKS------------VPMTIFHKTDS--------EDLQKK------------PLLVH----V-------Y---------------------------------------------------------G--------------------A-----------------------------------------------------------YGMDLKMN-FRP-ERRVLVDD-GWI-----L----------------------------------------AY------C-H---VR-GG----GE-----LG-LQWHA--D-GRLT-------KK-----------LNGLAD--LEAC----------------------------------------------I-----------------------------K--TL-------------------------------------------------H-GQGFS-QPS--------------------------------------------------------L----T-TL--T-A--FS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-LVGALC-------------------------------------N------------------------------------------SNP-E-LLRAV--TLE------------------------------------------------------------------------------------------------------APFL-------D---VLNT-------------------------------MMDTTLPLTLEELEEWGNPSSDEK------------------------------------------------HKNYIKRYCP---------------------------------------------------------------------------------------------------------------Y---QNI-KPQ---H------------------YPS-------------------------IH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IT-A-----YENDE--RVPL----------------KGIVNY---------------------------TEKLK----------EAITEHA---KDTGEGYQAPNV---VLDIQPG-G----------------------------------NH----------------------------VI----ED---------SHKKITAQIKFLYEELGLDSTS 116
117 --------RVLRMEAKS-KD--GKL------------VPMTVFHKTDS--------EDLQKK------------PLLVQ----V-------Y---------------------------------------------------------G--------------------A-----------------------------------------------------------YGMDLKMN-FRP-ERRVLVDD-GWI-----L----------------------------------------AY------C-H---VR-GG----GE-----LG-LQWHA--D-GRLT-------KK-----------LNGLAD--LEAC----------------------------------------------I-----------------------------K--TL-------------------------------------------------H-DQGFS-QPS--------------------------------------------------------L----T-AL--T-A--FS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-LVGALC-------------------------------------N------------------------------------------SSP-E-LLRAV--TLE------------------------------------------------------------------------------------------------------APFL-------D---VLNT-------------------------------MMDTTLPLTLEELEEWGNPSSDEN------------------------------------------------HKNYIKRYCP---------------------------------------------------------------------------------------------------------------C---QNI-KPQ---H------------------YPS-------------------------IH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IT-A-----YENDE--RVPL----------------KGIVNY---------------------------TEKLK----------EAIAEHA---KDSGEGYQVPNI---ILDIQPG-G----------------------------------NH----------------------------VI----ED---------SHKKITAQIKFLYEELGLDSTS 117
118 --------RVLRIEAKS-KD--GKL------------VPMTVFHKTDS--------EDLQRK------------PLLVH----V-------Y---------------------------------------------------------G--------------------A-----------------------------------------------------------YGMDLKMN-FRP-EKRVLVDD-GWI-----L----------------------------------------AY------C-H---VR-GG----GE-----LG-LQWHA--D-GRLT-------KK-----------LNGLAD--LVAC----------------------------------------------I-----------------------------K--TL-------------------------------------------------H-SQGFS-QPS--------------------------------------------------------L----T-TL--S-A--FS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-LVGALC-------------------------------------N------------------------------------------SKP-E-LLRAV--TLE------------------------------------------------------------------------------------------------------APFL-------D---VLNT-------------------------------MLDTTLPLTLEELEEWGNPSSDEK------------------------------------------------HKNYIKRYCP---------------------------------------------------------------------------------------------------------------C---QNI-KPQ---H------------------YPS-------------------------VH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IT-A-----YENDE--RVPL----------------KGIVNY---------------------------TEKLK----------EAVAEHT---KGAGEGYQPPNI---ILDIQPG-G----------------------------------NH----------------------------VI----ED---------SHKKITTQMKFLYEELGLDSTD 118
119 KHISIPEFNTTRLQATS-HD--GTM------------VPLTLFHMPAF--------SELCKA------------PLLLH----V-------Y---------------------------------------------------------G--------------------A-----------------------------------------------------------YGVDLNMT-FSP-EKRMMLED-GWT-----L----------------------------------------AY------C-H---VR-GG----GE-----RG-LSWHR--A-GSVL-------QK-----------QRGVED--LAAC----------------------------------------------I-----------------------------Q--TL-------------------------------------------------H-RLGVS-GPD--------------------------------------------------------L----T-AL--T-A--RS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I-LAGALC-------------------------------------N------------------------------------------QNP-Q-LIRAL--ILQ------------------------------------------------------------------------------------------------------APFL-------D---VLGT-------------------------------MQDTSLPLTLEEKGEWGDPLIRE-------------------------------------------------HRDNIASYCP---------------------------------------------------------------------------------------------------------------C---HNI-QPQ---L------------------YPS-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IT-A-----YSEDH--RVPV----------------SGVIKF---------------------------VERLK----------KAIQMCT---TQVDINARVPSV---ILDIQPG-A----------------------------------DH----------------------------FGP---EDFH------LSLNESARQLAFL---------- 119
120 ----------------------------LIEEQAVGGIPITIVR----------------SCVDQHLHQSDVAVLFLLH----GRKEPIKRY---------------------------------------------------------V--------------------E-----------------------------------------------------------HAKTL----VNAMTKQDNARSLGLV-----V----------------------------------------VL------F-E---QR-NH----GSRLVSAVANESWST----GNPTHATDMWSIQ-----------YGTAKD--VSFL----------------------------------------------M-----------------------------D--VL-------------------------------------------------PMHLSATMSVH--------------------------------------------------------R----W-GV--A-G--VS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-STLLAA-------------------------------------V------------------------------------------HEP---RLDVA--VSI------------------------------------------------------------------------------------------------------IGCG-------D----------------------------------------YASLMVPRAQASGLSISTDSCE-------------------------------------------CFPPSLVQILTRLDP---------------------------------------------------------------------------------------------------------------VNNVHKLDNQK--------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-G-----GGLDA--MVPP----------------SANKMF---------------------------IDRVR----------ERYGAEGKSEWF-------------DERIDPD-A----------------------------------GHTFSPWM-------------------------------------------MVQTQQWLCKYL------ 120
121 -----------------------------------IPAFLFTPTHRPP-----------------------------------------------------------------------------------------------------L--------------------G---------------------------------------------------------------------------------GVV-----VFHQHNGEFHFGKSEVAGDVGDPYQAFGPALARRGVAVLAPDS------V-TFEDRR-GAVQGVEP---------------EHYDWLRHYSAMAYRLLDGDTLM---RKCLDD--AQRA----------------------------------------------L-----------------------------S-----------------------------------------------------VLADATGVDGR--------------------------------------------------------H----I-GI--A-G--HS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-TALYHAA-----V--------------DA-------------RCQF-----------------------------------------------------VCISGAVCSFETRRREGTGITLFETVPGLARDIDTHDVLSAIGPRP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-S-----GTEDK--YSRDADQVVAKVTGH--FITERRVNR--------------------------------------------------------------------------------------------------------------GHALDQERFDAIVEWL----------------------------------------------------- 121
122 ---------------EVPGFPSIPETYITIND-----KELGLQEHCRGVNVLSCGYNLVGMFHTPTTPMPLGGYPTVIFFHGFRGNCTGKDG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-----YRDLA-------------------------------------------------------RLLT----------------------------------------------A-----------------------------N--GIAVARFDM---AGCGNSEGICDQIPARTYLRNG------------EDILATVAKYPEVNPH--------------------------------------------------------R----I-GI--A-G--IS-----------------LG-----------------------------C---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HTTIH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASTYRPRDYT--VQAISV-------------WAPIADGVILLKEICATIGLTMTQFSDMGEVGKAFGFKQLPLKLCRDDIDFFLGIQDHILLLSLPRRIPVLHQQ-----GLEDHVVSTAHQ---------------------------------------------------RLFLGAAPAQMLSKSY---PETP----------------------------------------------------------HEIASSPYRQEVLQEILTHFQSNL-------------------------------------------- 122
123 ---------------------------------------------------------IKGWLIVPKNRSGKLPGIVEYI----G-------Y---------------------------------------------------------G--------------------G-------------------------------------------GRSFAYD-----FLLW-------------------ANMGFI-----H----------------------------------------LI------M-D---TR-GQGSSWSPGDTPDYDDEPFDPQYS--GFMTRGILHPKK-----YYY---RRVFTD--AVRA----------------------------------------------V-----------------------------E--TIMAF-PDV--------------------------------------------------DKE--------------------------------------------------------R----I-GI--T-G--GS-----------------QG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-IT------------------------------------------IAVAGLVPYIGIDV-KIVMPDVPFLCHYRRAVEITDGYPYQEIVQYLKSHRDH--VDR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V--FKTLSYFDGVNFAV---RAKAK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FS-V-----ALMDN--ICPP--STVFAAYN------YYQGEKEI-----------------------------------------------------------------------KIYPF-------------------------------NGHE------------------------------------------------------------------ 123
124 ---------------------------------------------------------IKGWLIAPKNRSGKLPGIVEYI----G-------Y---------------------------------------------------------G--------------------G-------------------------------------------GRSFAYD-----FLLW-------------------ANMGFI-----H----------------------------------------LI------M-D---TR-GQGSSWSPGNTPDYDDEPFDPQYS--GFMTRGILHPKK-----YYY---RRVFTD--AVRA----------------------------------------------V-----------------------------E--TLMAF-PDV--------------------------------------------------DRE--------------------------------------------------------R----I-GI--T-G--GS-----------------QG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-IT------------------------------------------IAVAGLAPYVGIDI-KIAMPDVPFLCHYRRAVEITDGYPYQEIVQYLKTHRDH--VDK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V--FKTLSYFDGVNFAV---RAKAK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FS-V-----ALMDN--ICPP--STVFAAYN------YYGGEKEI-----------------------------------------------------------------------KVYPF-------------------------------NGHE------------------------------------------------------------------ 124
125 --------------------------------------------------------RITGWYAVP-DKEGPHPAIVKYH----G-------Y---------------------------------------------------------N--------------------A-----------------------------------------------SYDGEIHEMVNW-------------------ALHGYA-----T----------------------------------------FG------M-L---VR-GQQSS---------EDTSISPHGHALGWMTKGILDKDT-----YYY---RGVYLD--AVRA----------------------------------------------L-----------------------------E--VISSF-DEV--------------------------------------------------DET--------------------------------------------------------R----I-GV--T-G--GS-----------------QG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-LT------------------------------------------IAAAALS-----DIPKAAVADYPYLSNFERAIDVALEQPYLEINSFFRRNGSP--ETE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VQAMKTLSYFDIMNLAD---RVKVP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MS-I-----GLIDK--VTPP--STVFAAYN------HLETKKEL-----------------------------------------------------------------------KVYRY-------------------------------FGHE------------------------------------------------------------------ 125
126 ---------------------------------ESGEQGRVPVLLLSLNDTAP--K-------R---KP-----V-IVL----L-------H---------------------------------------------------------S-----------------------------------------------------------------------------------SYKCKEWLRPLLEAYASR-GYI-----S----------------------------------------VA------I-DSRYHG--E----RA---------------SHKTTYIDALKSSWKNGDTMPFI---FDTVWD--LIKL----------------------------------------------G-----------------------------D--HLAAR-E----------------------------------------D---V-------DPS--------------------------------------------------------R----I-GI--T-G--ES-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-HAW------------------------------------------FAAFV---------------------------DTRYSV-------------V--VPI------------------------------------------I-----GVQGFRW-----------------A------------------------------------------------------------IDNNMWQARVNSIKPLF--------EEARIDLGKSEIDAEVVEKVWEKIA-PGMASQFD---ALYTVPLI------VPR-------------------------------------------------------------------------------------------------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-N-----GAEDP--RCPI-LGLQ-----------EPA-SK-TSKAYGEAG-----------------SS-------E------------KFMFIAE--AG-------------V------------------------------------GHKM-----TETMVKEASDWF------------------------------------------------ 126
127 ---------------------------------EDSEQGKLPLLILSLKERSE--E-------K---RP-----A-IVF----M-------H---------------------------------------------------------G-----------------------------------------------------------------------------------TNTNKEWLRPWLEAYASR-GYV-----A----------------------------------------IG------L-DSRYHG--E----RA---------------DCKTAYRDALISSWRNGNTMPFI---FDTVWD--LIKL----------------------------------------------A-----------------------------E--YLTQR-D----------------------------------------D---I-------DPK--------------------------------------------------------K----I-GI--T-G--IS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-HAW------------------------------------------FAAAA---------------------------DTRYSV-------------V--VPL------------------------------------------I-----GVQGFRW-----------------A------------------------------------------------------------IENDEWEARVNSIKPLF--------EEARIDLGKNIIDKELVEKVWNRIA-PGLASKFD---SPYSLPVI------APR-------------------------------------------------------------------------------------------------------------------------------------P------------------------------------------------------------LY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-N-----GANDP--RCPL-GGLE-----------LAL-KR-AEKAYKETA-----------------SP-------G------------NFKFKAE--DG-------------V------------------------------------GHEA-----TSFMIKESSDWF------------------------------------------------ 127
128 FRGVQ--WSETFIMSSDGTKLAV--------------------------CEGRLPALFRRDRNVKENNKKRVRVV-ICY----F-------Q---------------------------------------------------------G--------------------NG--------------------------------------------------------------------------------GST-----PLRLPLLSLVMKSIEESSSSSSFHASNRDEVGFEYEYIIAALS------------YR-GY-----------------------------------WKSSGRATQ---RGIEAD--AAAF----------------------------------------------L-----------------------------N--WVYDA---------------------------------------YRDE---H-------DDL--------------------------------------------------------R----V-IL--W-G--HS-----------------LG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VAS---------------------------------------------------------------------------------------------S--ALARRLASTSSPGSPSATDTNIEIKSETPLTGAKEEKIAGLVLEAS------------------------------------------------------------------------------------------ISSI-------------------------------------------------------------------------------------------------------------------------------------------------------------KDM---------------LVALYPQKWLPYR-------YLHPFSW-NHWDVALNLEQLAQHKKPNHQQNQGQGSSPGNRHWSERVPP-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-S-----AENDE--VIPP----------------WVA-DQ-LEHRGRDFG------------------------------------L----DIVRVNVKG-------------A------------------------------------MHIEAPLKG------------------------------------------------------------ 128
129 ------------------------------------------PQPKDKTAYLEKRAAWEPHRRTFHHNGAKLSGWLI------------------------------------------------------------------------E--------------------K------------------------------------------------------------------------------------------------------------------------------------------KGQ-----------------------------------------------------------------------------------------------------------------------------------------------PLL------------VYYGGNAMDISMMLPYLDRFPH---AKLLVNYRGYG---L----STGSPTEQDIMG-------D-----------SLAILDSVLKETGRT---------------PDDV----IL--V-G--QS-----------------LG-----------------------------S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-VA--TQ-----------------------VASVRHVKK--------------------------LVLLVPFDSLLETARGLFPYLPVR----------LLLPDHFRSDLA--------------------------------AP----KVACPVSILA------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GADE--VIPPHHAKRLRDCF---SVPVSYQEF-----------------------------------------------------------------------------------------------------------PGAMH----------NT------IWLSP----GFDKAFSQSI------------------------------ 129
130 TIGLP--SENLYLRTADGVRINAVFI-KQPPVRL------------------------------------PFAPT-IMF----I-------H---------------------------------------------------------G--------------------NA--------------------------------------------------------------------------------GNI-----GHRLPFARELYHHCGVN---------------------VMLLE------------YR-GY-----------------------------------GKSDGVPSE---NGLKLD--ARAG----------------------------------------------L-----------------------------E--YLRD-----------------------------------------RTD---I-------DAS--------------------------------------------------------M----I-IV--F-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VGI---------------------------------------------------------------------------------------------D--LACQ---------------------------QLYTDAIRGLIVENS------------------------------------------------------------------------------------------FTSI-------------------------------------------------------------------------------------------------------------------------------------------------------------PAM---------------GEVLFS----ALR-------LLPMFCFRNKFNSKSIVKSV-R-V------------------------P-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-S-----GLSDE--LVPP----------------RMM-TE-LCNKSGAIF------------------------------------K----RIVRF--EN-------------G------------------------------------SHNGTWL-CPD--YYKCISFFIAQ--------------------------------------------- 130
131 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLYID--AESA----------------------------------------------F-----------------------------D--YLLK-----------------------------------------RSD---I-------DPS--------------------------------------------------------K----I-IL--F-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VAI---------------------------------------------------------------------------------------------N--VASS---------------------------PKYRDKLCALIVENT------------------------------------------------------------------------------------------FTSI-------------------------------------------------------------------------------------------------------------------------------------------------------------PDV---------------AKVLFR--IPILK-------WIPLWCHKNKYTNIRKIHRV-K-A------------------------P-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-S-----GMRDE--LIPP----------------RMM-QL-LFQTSISVM------------------------------------K----RLAKF--EN-------------G------------------------------------THNETWQ-SEG--YFETICQFIIEV-------------------------------------------- 131
132 ILDLP--YENLMIKTSDWVKISAVLL-KQPPDRA------------------------------------ARSPT-IVL----L-------H---------------------------------------------------------G--------------------NA--------------------------------------------------------------------------------GNL-----GHRLYNAKMLYTVSHCN---------------------VLLLD------------YR-GY-----------------------------------GRSEGTPSE---SGLYTD--AQST----------------------------------------------L-----------------------------D--YLHT-----------------------------------------RRD---I-------DPT--------------------------------------------------------Q----L-FV--F-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VAI---------------------------------------------------------------------------------------------H--IAAQ---------------------------KMNNGRLKGLIIENT------------------------------------------------------------------------------------------FTSI-------------------------------------------------------------------------------------------------------------------------------------------------------------QEM---------------GSHLFS-GA--VN-------WVPLCLVKNKFLSNRKVSSI-H-A------------------------P-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-A-----GTADE--LVPP----------------KMM-KD-LFMRCRAPK------------------------------------K----SMYCF--TG-------------G------------------------------------SHNETWH-CEN--YFQTIRDFL----------------------------------------------- 132
133 ---------------------------TQPNEKA------------------------------------LSSPT-MVY----F-------H---------------------------------------------------------G--------------------NA--------------------------------------------------------------------------------GNI-----GHRLHNAQVLYRHCGFN---------------------ILLVE------------YR-GY-----------------------------------GKSGGSPSE---SGLYLD--AEAA----------------------------------------------M-----------------------------E--YVMS-----------------------------------------RRD---I-------NQR--------------------------------------------------------K----I-VL--F-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VAI---------------------------------------------------------------------------------------------Y--LAAS---------------------------PKYCNDILALIVENT------------------------------------------------------------------------------------------FSSI-------------------------------------------------------------------------------------------------------------------------------------------------------------PHM---------------AQLMVPG----AS-------SLPRLFFKNKFLSYYEIKKV-R-A------------------------P-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-S-----GLMDQ--LIPP----------------QMM-ME-LYQACSSPL------------------------------------K----YIETF--QS-------------G------------------------------------THNGTWM-CYG--YYDHINKFMA---------------------------------------------- 133
134 ----------------DGVKISCYFIKQQPNEKA------------------------------------LSSPT-MVY----F-------H---------------------------------------------------------G--------------------NA--------------------------------------------------------------------------------GNI-----GHRLHNAQVLYRHCGFN---------------------ILLVE------------YR-GY-----------------------------------GKSGGSPSE---SGLYLD--AEAA----------------------------------------------M-----------------------------E--YVMS-----------------------------------------RRD---I-------NQR--------------------------------------------------------K----I-VL--F-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VAI---------------------------------------------------------------------------------------------Y--LAAS---------------------------PKYCNDILALIVENT------------------------------------------------------------------------------------------FSSI-------------------------------------------------------------------------------------------------------------------------------------------------------------PHM---------------AQLMVPG----AS-------SLPRLFFKNKFLSYYEIKKV-R-A------------------------P-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-S-----GLMDQ--LIPP----------------QMM-ME-LYQACSSPL------------------------------------K----YIETF--QS-------------G------------------------------------THNGTWM-CYG--YYDHINKFMA---------------------------------------------- 134
135 RFNLQ--GENHFLPTRDGIKINAVLI-KHSNP---------------------------------------NAPT-VVY----F-------H---------------------------------------------------------G--------------------NA--------------------------------------------------------------------------------GNI-----GHRYPNVGDLHRYVGVN---------------------VLLVE------------YR-GY-----------------------------------GRSEGSPSE---SGLYLD--SEAA----------------------------------------------M-----------------------------D--FLIS-----------------------------------------RPD---I-------NKD--------------------------------------------------------K----I-VV--F-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VAA---------------------------------------------------------------------------------------------W--LASS---------------------------KKYSPHIAALVLENT------------------------------------------------------------------------------------------FTSL-------------------------------------------------------------------------------------------------------------------------------------------------------------PDI---------------AKSIFADLF-ILE-------YIPVFLFKNKYPTLERIQKI-T-I------------------------P-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-S-----GQGDK--LIPP----------------HMM-SK-LSSVSGSSV------------------------------------K----KIVRF--PG-------------G------------------------------------THNETWM-SDG--YYEAWLFFLQEV-------------------------------------------- 135
136 TYGLL--HENIFAQTKDGVSINMILI-KQPSPLM------------------------------------GLAHT-IVI----F-------H---------------------------------------------------------G--------------------NA--------------------------------------------------------------------------------GNI-----GHRLPNCYALQTYLRAN---------------------VVLVE------------YR-GF-----------------------------------GKSGGKPSE---QGLYLD--AACA----------------------------------------------M-----------------------------D--YLLK-----------------------------------------RSD---I-------NPK--------------------------------------------------------K----L-VL--F-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VA-------------------------------------------------------------------------------------------------IQAA---------------------------SRYAANVHALIVENT------------------------------------------------------------------------------------------FTSL-------------------------------------------------------------------------------------------------------------------------------------------------------------PDI---------------GRHLF-DFR-VIR-------CLPKICFKNKYPSDQRISHL-S-V------------------------P-------------------------SL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-S-----GSSDN--LIPP----------------IMM-HK-LYELSCSPL------------------------------------K----RLAKF--PA-------------G------------------------------------THNDTWM-SPG--YYETMNRFLVEV-------------------------------------------- 136
137 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLVNLKVN---------------------LLLVD------------YR-GY-----------------------------------GKSEGEASE---EGLYLD--SEAV----------------------------------------------L-----------------------------D--YVMT-----------------------------------------RPD---L-------DKT--------------------------------------------------------K----I-FL--F-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VAI---------------------------------------------------------------------------------------------H--LASE-----------------------------NSHRISAIMVENT------------------------------------------------------------------------------------------FLSI-------------------------------------------------------------------------------------------------------------------------------------------------------------PHM---------------ASTLFSFFP--MR-------YLPLWCYKNKFLSYRKISQC-R-M------------------------P-------------------------SL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-S-----GLSDQ--LIPP----------------VMM-KQ-LYELSPSRT------------------------------------K----RLAIF--PD-------------G------------------------------------THNDTWQ-CQG--YFTALEQFIKEVI------------------------------------------- 137
138 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLVNLKVN---------------------LLLVD------------YR-GY-----------------------------------GKSEGEASE---EGLYLD--SEAV----------------------------------------------L-----------------------------D--YVMT-----------------------------------------RPD---L-------DKT--------------------------------------------------------K----I-FL--F-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VAI---------------------------------------------------------------------------------------------H--LASE-----------------------------NSHRISAIMVENT------------------------------------------------------------------------------------------FLSI-------------------------------------------------------------------------------------------------------------------------------------------------------------PHM---------------ASTLFSFFP--MR-------YLPLWCYKNKFLSYRKISQC-R-M------------------------P-------------------------SL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-S-----GLSDQ--LIPP----------------VMM-KQ-LYELSPSRT------------------------------------K----RLAIF--PD-------------G------------------------------------THNDTWQ-CQG--YFTALEQFIKEVI------------------------------------------- 138
139 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLVNLKVN---------------------LLLVD------------YR-GY-----------------------------------GKSEGEASE---EGLYLD--SEAV----------------------------------------------L-----------------------------D--YVMT-----------------------------------------RPD---L-------DKT--------------------------------------------------------K----I-FL--F-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VAI---------------------------------------------------------------------------------------------H--LASE-----------------------------NSHRISAIMVENT------------------------------------------------------------------------------------------FLSI-------------------------------------------------------------------------------------------------------------------------------------------------------------PHM---------------ASTLFSFFP--MR-------YLPLWCYKNKFLSYRKISQC-R-M------------------------P-------------------------SL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-S-----GLSDQ--LIPP----------------VMM-KQ-LYELSPSRT------------------------------------K----RLAIF--PD-------------G------------------------------------THNDTWQ-CQG--YFTALEQFIKEVV------------------------------------------- 139
140 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MT-----------------------------------------RPD---L-------DKT--------------------------------------------------------K----V-FL--F-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VAI---------------------------------------------------------------------------------------------H--LASE-----------------------------NSHRISAIMVENT------------------------------------------------------------------------------------------FLSI-------------------------------------------------------------------------------------------------------------------------------------------------------------PHM---------------ASTLFSFFP--MR-------YLPLWCYKNKFLSYRKISQC-R-M------------------------P-------------------------SL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-S-----GLSDQ--LIPP----------------VMM-KQ-LYELSPSRT------------------------------------K----RLAIF--PD-------------G------------------------------------THNDTWQ-CQG--YFTALEQFIKEVI------------------------------------------- 140
141 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLVNLKVN---------------------LILVD------------YR-GY-----------------------------------GKSEGEASE---EGLYID--SEAV----------------------------------------------L-----------------------------D--YVMT-----------------------------------------RSD---L-------DKT--------------------------------------------------------K----I-FL--F-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VAI---------------------------------------------------------------------------------------------H--LASE-----------------------------NSHRISAIMVENT------------------------------------------------------------------------------------------FLSI-------------------------------------------------------------------------------------------------------------------------------------------------------------PHM---------------ASTLFSFFP--MR-------YLPLWCYKNKFLSYRKISQC-R-M------------------------P-------------------------SL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-S-----GLSDQ--LIPP----------------VMM-KQ-LYELSPART------------------------------------K----RLAIF--PD-------------G------------------------------------THNDTWQ-CQG--YFTALEQFIKEVI------------------------------------------- 141
142 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D------------YR-GY-----------------------------------GKSEGEASE---EGLYLD--SEAV----------------------------------------------L-----------------------------D--YVMT-----------------------------------------RPD---L-------DKT--------------------------------------------------------K----I-FL--F-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VAI---------------------------------------------------------------------------------------------H--LASE-----------------------------NSHRISAIMVENT------------------------------------------------------------------------------------------FLSI-------------------------------------------------------------------------------------------------------------------------------------------------------------PHM---------------ASTLFSFFP--MR-------YLPLWCYKNKFLSYRKIAQC-R-M------------------------P-------------------------SL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-S-----GLSDQ--LIPP----------------VMM-KQ-LYELSPSRT------------------------------------K----RLAIF--PD-------------G------------------------------------THNDTWQ-CQG--YFTALEHFIREAI------------------------------------------- 142
143 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLVNLKVN---------------------LLLVD------------YR-GY-----------------------------------GKSEGEASE---EGLYLD--SEAV----------------------------------------------L-----------------------------D--YIMT-----------------------------------------RSD---L-------DKT--------------------------------------------------------K----I-FL--F-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VAI---------------------------------------------------------------------------------------------H--LASE-----------------------------NSHRISAIMVENT------------------------------------------------------------------------------------------FLSI-------------------------------------------------------------------------------------------------------------------------------------------------------------PHM---------------ATTLFSFFP--MR-------YLPLWCYKNKFLSYRKISQC-R-M------------------------P-------------------------SL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-S-----GLADQ--LIPP----------------VMM-KQ-LYELSPART------------------------------------K----RLAIF--PD-------------G------------------------------------THNDTWQ-CQG--YFTALEQFIKEVL------------------------------------------- 143
144 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D--ARSV----------------------------------------------L-----------------------------D--HLFS-----------------------------------------RHD---L-------DHG--------------------------------------------------------Q----I-VV--F-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VSI---------------------------------------------------------------------------------------------D--LAAD---------------------------AVYGAKLMGVIVENT------------------------------------------------------------------------------------------FTSI-------------------------------------------------------------------------------------------------------------------------------------------------------------PDM---------------AVELIH---PAVQ-------YLPLVLYRNQYLSVDKIQFV-S-A------------------------P-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FV-S-----GLADT--LVPP----------------RMM-TM-LHTRCGSTR------------------------------------K----QMLQI--VG-------------G------------------------------------SH------------------------------------------------------------------- 144
145 MHNLP--HITVSIKTPDDVTLHAFWV-TQPEERS------------------------------------KSSPT-LLY----F-------H---------------------------------------------------------G--------------------NA--------------------------------------------------------------------------------GNM-----GHRMQNVWGIYHHLHCN---------------------VLMVE------------YR-GY-----------------------------------GLSTGVPTE---RGLVTD--ARAA----------------------------------------------I-----------------------------D--YLHT-----------------------------------------RHD---L-------DHS--------------------------------------------------------Q----L-IL--F-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VVV---------------------------------------------------------------------------------------------D--VAAD---------------------------TVYGQKLMCAIVENT------------------------------------------------------------------------------------------FSSI-------------------------------------------------------------------------------------------------------------------------------------------------------------PEM---------------AVELVH---PAVK-------YIPNLLFKNKYHSMSKIGKC-S-V------------------------P-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-S-----GLADN--LVPP----------------RMM-RA-LYTKCGSEI------------------------------------K----RLLEF--PG-------------G------------------------------------SHNDTWI-VDG--YYQAIGGFLAELQ------------------------------------------- 145
146 YLGVP--YENLYIKTRDGITLNAIFL-KQSGNRL------------------------------------NIAPT-IIM----L-------H---------------------------------------------------------G--------------------NA--------------------------------------------------------------------------------GNI-----GHRFSLAQLLYMYTGSN---------------------IFLLD------------YR-GY-----------------------------------GKSDGMPSE---KGFELD--AIAA----------------------------------------------I-----------------------------E--YLLS-----------------------------------------HSD---I-------DHN--------------------------------------------------------K----L-VL--Y-G--SS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VTF---------------------------------------------------------------------------------------------A--VAFY---------------------------KKYMNLLFAIIVENT------------------------------------------------------------------------------------------FTSI-------------------------------------------------------------------------------------------------------------------------------------------------------------PDM---------------ARHLF---I-LVN-------KLPSWCYKNKFPSIDRVAVI-T-T------------------------P-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-S-----GLADQ--LVPP----------------KQM-VQ-LYNSSGACL------------------------------------K----RIERF--DA-------------G------------------------------------SHNDTWQ-CNG--YMDSINNFLNE--------------------------------------------- 146
147 EFSIE--YEDLMIPCKDGVKINAWLM-KQKEH--------------------------------------STRPT-LIF----F-------H---------------------------------------------------------G--------------------NA--------------------------------------------------------------------------------GNI-----GYRLPNAVQLFRKVGAN---------------------ILLVD------------YR-GF-----------------------------------GHSEGTPSE---EGIKLD--AEAV----------------------------------------------L-----------------------------D--AMYA-----------------------------------------RTD---I-------DSS--------------------------------------------------------N----L-VA--F-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VSV---------------------------------------------------------------------------------------------Y--LA-----------------------------EKEPSRVAAVVLENT------------------------------------------------------------------------------------------FLSI-------------------------------------------------------------------------------------------------------------------------------------------------------------SAM---------------VDALM----PFLT-------YVKPLVLRMDWDNERAIQKL-K-Q------------------------P-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-A-----GMQDE--LVPH----------------SHM-EK-LRSLATSS-------------------------------------Q----RVVWFPVPG-------------G------------------------------------THNDSWL-RGGDKYYSELRQFLE---------------------------------------------- 147
148 P-NIP--YDDVFITTSDKVKLHAYFI-KQQENEI------------------------------------QDAPT-LVY----F-------H---------------------------------------------------------G--------------------NA--------------------------------------------------------------------------------GNI-----GS--PSYIPLYMTCHVN---------------------ILLVE------------YR-GY-----------------------------------GKSEGSPSE---GGLYLD--GEAA----------------------------------------------L-----------------------------L--YLFD-----------------------------------------RQD---I-------NIR--------------------------------------------------------K----V-VL--F-G--HS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VAI---------------------------------------------------------------------------------------------H--LATR---------------------------SEFADRIAAVIVENT------------------------------------------------------------------------------------------FTNI-------------------------------------------------------------------------------------------------------------------------------------------------------------QAV---------------ACHLFRNILPFVS-------YLPRWAVKNKFMSSQKIPDI-Q-C------------------------P-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-Y-----GDNDE--IVPS----------------EMA-RA-LHEASRNPR------------------------------------S----AVVEI--TN-------------G------------------------------------THNDTWC-VTP--LYR----------------------------------------------------- 148
149 RLRL--IYEDVWLRAADGVRLHSWFLRHSPTCRG---------------------------------------PT-ILF----F-------Q---------------------------------------------------------E--------------------NA--------------------------------------------------------------------------------GNI-----AHRLECVRLMMQRLQCN---------------------VFMLS------------YR-GY-----------------------------------GESEGYPSQ---DGITKD--AQAA----------------------------------------------L-----------------------------D--HLLQ-----------------------------------------RKD---I-------DTS--------------------------------------------------------R----I-VI--F-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VGA---------------------------------------------------------------------------------------------V--LA-----------------------------KNNPDKVSALILENT------------------------------------------------------------------------------------------FTSI-------------------------------------------------------------------------------------------------------------------------------------------------------------LDM---------------AGIMLPFLRWFIGGSSAKGPKLLNCVVRSPWNTLDVVAEV-K-Q------------------------P-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CL-S-----GLQDE--LVPP----------------SHM-RM-LYDKASEHN------------------------------------KNC--RFVDF--PN-------------G------------------------------------MHMDTWI-SGGDRYWRTIQLFLDQ--------------------------------------------- 149
150 RLNL--IYEDIWLQSSDGVRLHAWFIKMFPECRG---------------------------------------PT-ILF----F-------Q---------------------------------------------------------E--------------------NA--------------------------------------------------------------------------------GNI-----AHRLEMVRIMIQKLKCN---------------------VFMLS------------YR-GY-----------------------------------GASEGYPSQ---QGIIKD--AQAA----------------------------------------------L-----------------------------D--HLSG-----------------------------------------RTD---I-------DTS--------------------------------------------------------R----I-VV--F-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VGA---------------------------------------------------------------------------------------------V--LT-----------------------------KNNPDKVSALILENT------------------------------------------------------------------------------------------FTSI-------------------------------------------------------------------------------------------------------------------------------------------------------------LDM---------------AGVLLPFLKWFIGGSGTKSLKLLNFVVRSPWKTIDAIAEI-K-Q------------------------P-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-S-----GLQDE--MVPP----------------FHM-KM-LYAKAAARN------------------------------------PQC--TFVEF--PS-------------G------------------------------------MHMDTWL-SGGEVYWKTNLQFLEK--------------------------------------------- 150
151 QFGIE-DYEELQLRTPDGESLHAYFI-RAPRKRV------------------------------------DQNLT-VLM----F-------H---------------------------------------------------------G--------------------NA--------------------------------------------------------------------------------GNV-----GHRIPIAKIMQDYLGCH---------------------VLMLE------------YR-GY-----------------------------------GLSTGVPDE---HGLKID--AQTA----------------------------------------------L-----------------------------D--HLRL-----------------------------------------RGE---T-------ANS--------------------------------------------------------R----I-VV--Y-G--QS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VAI---------------------------------------------------------------------------------------------N--LVAN---------------------------NEDKGSISGLILENT------------------------------------------------------------------------------------------FLSI-------------------------------------------------------------------------------------------------------------------------------------------------------------RKLIPRHVPSSISASNICTMITISSVFPPAR-------YLARFCHQT-WTSEEVLPKITK-T------------------------P-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-S-----GLQDE--IVPP----------------SNM-TQ-LFAICNSKR------------------------------------K----VWRTL--PN-------------G------------------------------------AHNDSVA-EPD--YFEHIHSFV----------------------------------------------- 151
152 LYGLP--YQELRLRTRDGVEIRAFDIRNL-----------------------------------------RSKGT-ILV----L-------A---------------------------------------------------------P--------------------NG--------------------------------------------------------------------------------GNI-----GYFLSVAELLYRQMGLS---------------------VFLYS------------YR-GY-----------------------------------GYSEGEPSE---QGLKLD--ADRV----------------------------------------------M-----------------------------E--YMRK-----------------------------------------DEF---Y-------RTQ--------------------------------------------------------R----L-VL--Y-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-NAL---------------------------------------------------------------------------------------------Y--IA-----------------------------RKYGAQCDALILENT------------------------------------------------------------------------------------------FLSI-------------------------------------------------------------------------------------------------------------------------------------------------------------PKV---------------IPYVFPYL------------RYVSFLCREVWNSEEEIRLVDETI------------------------P-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-S-----GLKDE--IVPP----------------SHM-QA-LYSLSKSSG------------------------------------K----KFVTF--AD-------------G------------------------------------YHNDTII-QNG--YWDVVHDFLQK--------------------------------------------- 152
153 SRGIP--YEKLTLITQDHIKLEAWDIKNE-----------------------------------------NSTST-VLI----L-------C---------------------------------------------------------P--------------------NA--------------------------------------------------------------------------------GNI-----GYFILIIDIFYRQFGMS---------------------VFIYS------------YR-GY-----------------------------------GNSEGSPSE---KGLKLD--ADCV----------------------------------------------I-----------------------------S--HLST-----------------------------------------DSF---H-------SKR--------------------------------------------------------K----L-VL--Y-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-NAL---------------------------------------------------------------------------------------------Y--IA-----------------------------SKFRDLCDGVILENT------------------------------------------------------------------------------------------FLSI-------------------------------------------------------------------------------------------------------------------------------------------------------------RKV---------------IPYIFPLL------------KRFTLLCHEIWNSEGLMGSCSSET------------------------P-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-S-----GLKDE--IVPP----------------FHM-RK-LYETCPSSN------------------------------------K----KIFEF--PL-------------G------------------------------------SHNDTII-QDG--YWDIIRDFLIEKG------------------------------------------- 153
154 QFGLEDNFEEIFLTTSDGIKIQTWFFRQENSKSV---------------------------------------PT-LLF----C-------H---------------------------------------------------------S--------------------NA--------------------------------------------------------------------------------GNL-----SHRLDNIRHLFENVRCN---------------------VLILS------------YR-GY-----------------------------------GKSQGSPTE---IGLKKD--IDAC----------------------------------------------M-----------------------------E--YLLN-----------------------------------------DPT---I-------DPN--------------------------------------------------------T----I-MC--F-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VAI---------------------------------------------------------------------------------------------D--TA-----------------------------YRYPNNIKALILENT------------------------------------------------------------------------------------------FASV-------------------------------------------------------------------------------------------------------------------------------------------------------------PDM---------------VDAVLPML------------KLFKPFCRSRWDSKETIKHI-T-C------------------------D-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-S-----AKNDE--LVPA----------------SHM-KL-L----EKHA------------------------------------HQCKKKTIVF--EN-------------G------------------------------------RHMD----------------------------------------------------------------- 154
155 EVGCP--YEDVTLTCSDGVKIKAYVIMARRKPLMMSELRGLSPAERKEKAQMEMEAWAQEMGDEKAIEYSKSRPT-III----F-------H---------------------------------------------------------A--------------------NA--------------------------------------------------------------------------------GNM-----GHRVPLARHFNVDFKCN---------------------VFMLS------------YR-GY-----------------------------------GLSEGKPSE---SGLQID--IQTA----------------------------------------------M-----------------------------K--YVQA-----------------------------------------HPI---L-------GQT--------------------------------------------------------K----I-IL--Y-G--QS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-ACF---------------------------------------------------------------------------------------------Y--AA-----------------------------SKHRDTVAGVIVENT------------------------------------------------------------------------------------------MLSF-------------------------------------------------------------------------------------------------------------------------------------------------------------QTL---------------VPLIMPQIP---R-------FLLPILLTEHWDAHKTVPLIPSTT------------------------P-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-V-----GKRDT--LVKA----------------EQM-LA-LRKLRGSGI------------------------------------T----RWREF---D-------------G------------------------------------EHNDTCL-QPG--YWEEIGKWL----------------------------------------------- 155
156 ----------------------------------------------------------------------------VVH----F-------H---------------------------------------------------------G--------------------NG--------------------------------------------------------------------------------EVV-----SDYLGDFLHILESLGAN---------------------VFIAE------------YR-GY-----------------------------------SMSDGSP-Q---LGEMLD--DVVA----------------------------------------------M-----------------------------V--NAIG-----------------------------------------EP-------------AE--------------------------------------------------------K----L-IF--F-G--RS-----------------VG-----------------------------S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I-FAL---------------------------------------------------------------------------------------------E--AAHR------------------------------FPTAAGLILESG------------------------------------------------------------------------------------------I----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADPLERILLRVSPGEMGTTMEKLQLEVRQRLDHRAKIGGY-G-G------------------------P-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----TRHDG--LVDV----------------SHG-ER-LHEWAGGKK------------------------------------Q-----LRVF--AN-------------G------------------------------------NHNDIML-VNAAEY------------------------------------------------------- 156
157 --GLD--YRDVRFQAADDTRLHGWFV-PVPQARA----------------------------------------T-VIF----F-------H---------------------------------------------------------G--------------------NA--------------------------------------------------------------------------------GNI-----SHRLQTIR-VFHDLGLS---------------------VLIFD------------YR-GY-----------------------------------GLSEGTPDE---KGLQLD--AVAA----------------------------------------------W-----------------------------Q--AALA-----------------------------------------QPE---V-------DAE--------------------------------------------------------R----I-VF--W-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-IAA---------------------------------------------------------------------------------------------C--GALQ--------------------------AQRQGGAPVAVVLEST------------------------------------------------------------------------------------------FTSL-------------------------------------------------------------------------------------------------------------------------------------------------------------PDL---------------AAQLYPFLP--AR-------RLSRFHFDTRDAAAQLV------S------------------------P-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-H-----SRDDE--VVPF----------------SHG-EE-LSAISGPE---------------------------------------------AFVVLR-------------G------------------------------------GHNDGFL-RDAQTY------------------------------------------------------- 157
158 ------SAESVEFTAKDGTRLQGWFIPSSTGPAD------------------------------------NAIAT-IIH----A-------H---------------------------------------------------------G--------------------NA--------------------------------------------------------------------------------GNM-----SAHWPLVSWLPER-NFN---------------------VFMFD------------YR-GF-----------------------------------GKSKGTPSQ---AGLLDD--TQSA----------------------------------------------I-----------------------------N--VVRH-----------------------------------------RSD---V-------NPQ--------------------------------------------------------R----L-VL--F-G--QS-----------------IG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-NIL---------------------------------------------------------------------------------------------D--VIG----------------------------QGDREGIRAVILDST------------------------------------------------------------------------------------------FASY-------------------------------------------------------------------------------------------------------------------------------------------------------------ATI---------------ANQMIPGSGYLLD---------------ESYSGENYIASV-SPI------------------------P-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GKADH--VIPW----------------QHS-EK-LYSLAKEPK-----------------------------------------RLILI--PD-------------G------------------------------------EHIDAFSDRHGDVYREQMVDFIL---------------------------------------------- 158
159 ------------------------------------------------------------------------PMVIILHGFCDDRNEINFVH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NELSQR----------------------LCKEGIASVRFDMNGSGESDGKFEDMTISSEIADAKAMLE-------------------------------------------------------------------------------YVRSL-----------------------------------------------------------------------------------------------------------DFVDKKK----I-AL--H-G--CS-----------------LG-----------------------------G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CVASMVAGQCKDQIQALSMWCPAPDL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLQDHLTLCGQDVSNIEKDGCADVEGLKLSLKF-------------------------------------------------------YQDACTLDPFKEAAKFDKKVLTIHGDQDITASCTCSYKYKEIFKERAQCIIVKGAEHRFK---------------------------------------------------------------- 159
160 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SR-----------------------------------------------------------------------------------------------------------YGVSPEN----I-IL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPTVD-----L--------------AS-------------RY--ECAAVILHSPLMSGLRVAF--P-----DTRKTYCFDAFP-----------------------SIDKISKVTSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTEDE--VIDFSHGLAMYERCPRAVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDIE-LYAQYLE---RLK-QFISHEL----------------------------------------- 160
161 ARDNRLGCM------FVRCA---PSSR-----------------------------------------------YTLLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMCSF----YIGLG----SRINCNIFSYDYSGYGVSSGKPSE---KNLYAD--IDAA----------------------------------------------W-----------------------------Q--ALRTR-----------------------------------------------------------------------------------------------------------YGVSPEN----I-IL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPTVD-----L--------------AS-------------RY--ECAAVILHSPLMSGLRVAF--P-----DTRKTYCFDAFP-----------------------SIDKISKVTSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTEDE--VIDFSHGLAMYERCPRAVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDIE-LYAQYLE---RLK-QFISHEL----------------------------------------- 161
162 ARDNRLGCM------FVRCA---PSSR-----------------------------------------------YTLLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMCSF----YIGLG----SRINCNIFSYDYSGYGVSSGKPSE---KNLYAD--IDAA----------------------------------------------W-----------------------------Q--ALRTR-----------------------------------------------------------------------------------------------------------YGVSPEN----I-IL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPTVD-----L--------------AS-------------RY--ECAAVILHSPLMSGLRVAF--P-----DTRKTYCFDAFP-----------------------SIDKISKVTSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTEDE--VIDFSHGLAMYERCPRAVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDIE-LYAQYLE---RLK-QFISHEL----------------------------------------- 162
163 ARDNRLGCM------FVRCA---PSSR-----------------------------------------------YTLLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMCSF----YIGLG----SRINCNVFSYDYSGYGVSTGKPSE---KNLYAD--IDAA----------------------------------------------W-----------------------------Q--ALRTR-----------------------------------------------------------------------------------------------------------YGVSPEN----I-IL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPTVD-----L--------------AS-------------RY--ECAAVILHSPLMSGLRVAF--P-----DTRKTYCFDAFP-----------------------SIDKISKVTSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTEDE--VIDFSHGLAMYERCPRAVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDIE-LYAQYLE---RLK-QFISHEL----------------------------------------- 163
164 ARDNRLGCM------FVRCA---PTGR-----------------------------------------------YTLLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMCSF----YIGLG----SRINCNVFSYDYSGYGVSTGKPSE---KNLYAD--IDAA----------------------------------------------W-----------------------------Q--ALRTR-----------------------------------------------------------------------------------------------------------YGVSPEN----I-IL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPTVD-----L--------------AS-------------RY--ECAAVILHSPLMSGLRVAF--P-----DTRKTYCFDAFP-----------------------SIDKISKVTSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTEDE--VIDFSHGLAMYERCPRAVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDIE-LYAQYLE---RLK-QFISHEL----------------------------------------- 164
165 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-----------------------------------------------------------------------------------------------------------YGVSPEN----I-IL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPTVD-----L--------------AS-------------RY--ECAAVILHSPLMSGLRVAF--P-----DTRKTYCFDAFP-----------------------SIDKISKVTSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTEDE--VIDFSHGLAMYERCPRAVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDIE-LYAQYLD---RLK-QFISHEL----------------------------------------- 165
166 ARGNRIACL------FVKCS---ANAR-----------------------------------------------FTLLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMTTF----FIGLG----QRINCNIFSYDYSGYGQSSGKPTE---KNLYAD--IDAA----------------------------------------------W-----------------------------H--ALRTR-----------------------------------------------------------------------------------------------------------YGISPEN----I-IL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPTVD-----L--------------AS-------------RY--EVGAVILHSPLMSGMRVAF--P-----ATKRTWFFDAFP-----------------------SIDKVPKVTSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTEDE--VIDFSHGMTIYEKCPRAVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDVE-MYSQYLE---RLK-QFVSVEL----------------------------------------- 166
167 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DAG----------------------------------------------W------------------------------------W-----------------------------------------------------------------------------------------------------------YGVSPEN----I-IL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPTVD-----L--------------AS-------------RY--ECAAVILHSPLMSGLRVAF--P-----DTRKTYCFDAFP-----------------------SIDKISKVTSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTEDE--VIDFSHGLAMYERCPRAVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDIE-LYAQYLE---RLK-QFISHEL----------------------------------------- 167
168 SRGNRVGCM------FVRCA---PASR-----------------------------------------------YTLLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMCSF----YIGLG----SRINCNVFSYDYSGYGVSTGKPSE---KNLYAD--IEAA----------------------------------------------W-----------------------------Q--VLRNK-----------------------------------------------------------------------------------------------------------YGVTPEN----I-IL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPTVD-----L--------------AS-------------RY--ECAAVILHSPLMSGLRVAF--P-----DTRKTYCFDAFP-----------------------SIDKVSKVASPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTEDE--VIDFSHGLAIYERCPRAVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDIE-LYAQYLE---RLK-QFITFEL----------------------------------------- 168
169 KRGNRIACM------FVRCA---PNPK-----------------------------------------------YTILF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------IG--QMSSF----YIGLG----SRLNCNIFSYDYSGYGSSSGKPLE---RNLYAD--IEAA----------------------------------------------W-----------------------------Q--ALRSR-----------------------------------------------------------------------------------------------------------YGISPEN----I-IL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPTVD-----L--------------AS-------------RY--ESAAVILHSPLMSGMRVAF--P-----DTRRTWWFDPFP-----------------------SIDKCSKVASPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTEDE--VIDFSHGLAIYERCQHTVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDVE-LFGQYLE---RLR-NFITQEL----------------------------------------- 169
170 SRGNRVGCM------YVRCA---PGAR-----------------------------------------------FTVLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMCSF----YISLG----TRINCNIFSYDYSGYGVSSGKPSE---KNLYAD--VDAA----------------------------------------------W-----------------------------Q--ALRTR-----------------------------------------------------------------------------------------------------------YGISPEN----I-IL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPTVD-----L--------------AS-------------RY--ECAAVVLHSPLTSGMRVAF--P-----ETKKTYCFDAFP-----------------------NIDKVSRITSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LFIH-----GTEDE--VIDFSHGLALYERCPKAVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDIE-LYSQYLE---RLR-KFIAQDL----------------------------------------- 170
171 SRGNRVSCM------YVRCV---PGAR-----------------------------------------------YTVLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMSSF----YIGLG----SRINCNIFSYDYSGYGVSSGKPSE---KNLYAD--IDAA----------------------------------------------W-----------------------------Q--ALRTR-----------------------------------------------------------------------------------------------------------YGISPDS----I-VL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPTVD-----L--------------AS-------------RY--ECAAVVLHSPLTSGMRVAF--P-----DTKKTYCFDAFP-----------------------NIEKVSKITSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIIH-----GTEDE--VIDFSHGLALYERCPKAVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDIE-LYSQYLE---RLR-RFISQEL----------------------------------------- 171
172 SRGNRISCM------YVRCV---PGAR-----------------------------------------------YTVLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMSSF----YIGLG----TRINCNIFSYDYSGYGVSSGKPSE---KNLYAD--IDAA----------------------------------------------W-----------------------------Q--ALRTR-----------------------------------------------------------------------------------------------------------YGISPDS----I-VL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPTVD-----L--------------AS-------------RY--ECAAVVLHSPLTSGMRVAF--P-----DTKKTYCFDAFP-----------------------NIEKVSKITSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIIH-----GTEDE--VIDFSHGLALYERCPKAVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDIE-LYSQYLE---RLR-RFISQEL----------------------------------------- 172
173 ARGNRVSCM------YVRCV---PGAR-----------------------------------------------YTVLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMSSF----YIGLG----SRLHCNIFSYDYSGYGASSGRPSE---RNLYAD--IDAA----------------------------------------------W-----------------------------Q--ALRTR-----------------------------------------------------------------------------------------------------------YGISPDS----I-IL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPTVD-----L--------------AS-------------RY--ECAAVVLHSPLTSGMRVAF--P-----DTKKTYCFDAFP-----------------------NIEKVSKITSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIIH-----GTEDE--VIDFSHGLALYERCPKAVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDIE-LYSQYLE---RLR-RFISQEL----------------------------------------- 173
174 SRGNRIGCM------YVRCV---PGAR-----------------------------------------------YTVLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMSSF----YIGLG----TRINCNIFSYDYSGYGASTGKPSE---RNLYSD--IDAA----------------------------------------------W-----------------------------Q--ALRTR-----------------------------------------------------------------------------------------------------------YGISPEN----I-IL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPTVD-----L--------------AS-------------RY--ECAAIVLHSPLTSGMRVAF--P-----ETKKTYWFDAFP-----------------------NIEKISKITSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIIH-----GTEDE--VIDFSHGLALFERCPKAVEPLWVDGA--------------------------------------------------------------------------------------------------------------GHNDIE-LYSQYLE---RLR-KFISQEL----------------------------------------- 174
175 ARANRIACM------YVRCV---PGAR-----------------------------------------------YTVLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMCSF----YVGLG----TRIGCNIFSYDYSGYGISSGRPSE---KNLYAD--IDAA----------------------------------------------W-----------------------------Q--ALRTR-----------------------------------------------------------------------------------------------------------YGISPDS----I-IL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPTVD-----L--------------AS-------------RY--ECAAVVLHSPLTSGMRVAF--P-----DTKKTYCFDAFP-----------------------NIEKVSKITSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIIH-----GTEDE--VIDFSHGLALYERCPKAVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDIE-LYSQYLE---RLR-RFISQEL----------------------------------------- 175
176 SKGNRIACM------FVRCS---PNAK-----------------------------------------------YTLLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMSSF----YIGLG----SRINCNIFSYDYSGYGASSGKPTE---KNLYAD--IEAA----------------------------------------------W-----------------------------L--ALRTR-----------------------------------------------------------------------------------------------------------YGIRPEN----V-II--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPSVD-----L--------------AA-------------RY--ESAAVILHSPLTSGMRVAF--P-----DTKKTYCFDAFP-----------------------NIDKISKITSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIIH-----GTEDE--VIDFSHGLALFERCQRPVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDVE-LYGQYLE---RLK-QFVSQEL----------------------------------------- 176
177 SKGNRIACM------FVRCS---PNAK-----------------------------------------------YTLLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMSSF----YIGLG----SRINCNIFSYDYSGYGASSGKPTE---KNLYAD--IEAA----------------------------------------------W-----------------------------L--ALRTR-----------------------------------------------------------------------------------------------------------YGIRPEN----V-II--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPSVD-----L--------------AA-------------RY--ESAAVILHSPLTSGMRVAF--P-----DTKKTYCFDAFP-----------------------NIDKISKITSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIIH-----GTEDE--VIDFSHGLALFERCQRPVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDVE-LYGQYLE---RLK-QFVSQEL----------------------------------------- 177
178 SKGNRIACM------FVRCS---PNAK-----------------------------------------------YTLLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMSSF----YIGLG----SRINCNIFSYDYSGYGASSGKPTE---KNLYAD--IEAA----------------------------------------------W-----------------------------L--ALRTR-----------------------------------------------------------------------------------------------------------YGIRPEN----V-II--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPSVD-----L--------------AA-------------RY--ESAAVILHSPLTSGMRVAF--P-----DTKKTYCFDAFP-----------------------NIDKISKITSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIIH-----GTEDE--VIDFSHGLALFERCQRPVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDVE-LYGQYLE---RLK-QFVSQEL----------------------------------------- 178
179 SKGNRIACM------FVRCS---PNAK-----------------------------------------------YTLLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMSSF----YIGLG----SRINCNIFSYDYSGYGASSGKPTE---KNLYAD--IEAA----------------------------------------------W-----------------------------L--ALRTR-----------------------------------------------------------------------------------------------------------YGIRPEN----V-II--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPSVD-----L--------------AA-------------RY--ESAAVILHSPLTSGMRVAF--P-----DTKKTYCFDAFP-----------------------NIDKISKITSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIIH-----GTEDE--VIDFSHGLALFERCQRPVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDVE-LYGQYLE---RLK-QFVSQEL----------------------------------------- 179
180 SKGNRIACM------FVRCS---PNAK-----------------------------------------------YTLLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMSSF----YIGLG----SRINCNIFSYDYSGYGASSGKPTE---KNLYAD--VEAA----------------------------------------------W-----------------------------L--ALRTR-----------------------------------------------------------------------------------------------------------YGIRPEN----V-II--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPSVD-----L--------------AA-------------RY--ESAAVILHSPLTSGMRVAF--P-----DTKKTYCFDAFP-----------------------NIDKISKITSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIIH-----GTEDE--VIDFSHGLALFERCQRPVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDVE-LYGQYLE---RLK-QFVSQEL----------------------------------------- 180
181 SKGNRIACM------FVRCS---PNAK-----------------------------------------------YTLLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMSSF----YIGLG----SRINCNIFSYDYSGYGASSGKPSE---KNLYAD--IDAA----------------------------------------------W-----------------------------V--ALRTR-----------------------------------------------------------------------------------------------------------YGIRPEN----V-II--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPSVD-----L--------------AA-------------RY--ESAAVILHSPLTSGMRVAF--P-----DTKKTYCFDAFP-----------------------NIDKISKITSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIIH-----GTEDE--VIDFSHGLALFERCQRPVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDVE-LYGQYLE---RLK-RFVSQEL----------------------------------------- 181
182 SKGNRIACM------FVRCS---PNAK-----------------------------------------------YTLLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMSSF----YIGLG----SRINCNIFSYDYSGYGASSGKPTE---KNLYAD--IDAA----------------------------------------------W-----------------------------V--ALRTR-----------------------------------------------------------------------------------------------------------YGIRPEN----V-II--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPSVD-----L--------------AA-------------RY--ESAAVILHSPLTSGMRVAF--P-----DTKKTYCFDAFP-----------------------NIDKISKITSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIIH-----GTEDE--VIDFSHGLALFERCQRPVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDVE-LYGQYLE---RLK-QFVSQEL----------------------------------------- 182
183 SRGNRIACM------FVRCS---PNAR-----------------------------------------------YTLLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMSSF----YIGLG----SRINCNVFSYDYSGYGASSGKPSE---KNLYAD--VDAA----------------------------------------------W-----------------------------H--ALRTR-----------------------------------------------------------------------------------------------------------YGIRPEN----V-II--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPSVD-----L--------------AS-------------RY--ESAAVVLHSPLTSGMRVAF--P-----DTKKTYCFDAFP-----------------------NIDKISKVTSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTEDE--VIDFSHGLALYERCQRPVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDVE-LYGQYLE---RLK-QFVAHEL----------------------------------------- 183
184 SKGNRIACM------MVRCS---PNAK-----------------------------------------------YTMLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMSSF----YIGLG----SRINCNIFSFDYSGYGNSSGKPSE---KNLYAD--IDAA----------------------------------------------W-----------------------------Q--SLRSR-----------------------------------------------------------------------------------------------------------YGISPQN----V-IL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPTID-----L--------------AA-------------RY--EVGAAILHSPLMSGMRVAF--P-----ETKRTWFFDAFP-----------------------SIDKVPKITCPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTEDE--VIDFSHGLAIYEKCPRAVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDVE-LYGQYLE---RLK-QFINIEL----------------------------------------- 184
185 SRGNRIACA------YIRCC---PTAK-----------------------------------------------YTVLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMTSF----YIGLG----SRINCNIFSFDYSGYGVSSGKPAE---KNLYSD--IEAA----------------------------------------------W-----------------------------Q--TLRTR-----------------------------------------------------------------------------------------------------------YGISPEK----I-IL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPTID-----L--------------AA-------------RY--EVGAVVLHSPLMSGMRVAF--P-----DTKRTWFFDAFP-----------------------SIDKVPKITSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTEDE--VIDFSHGLAIYERCPRTVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDVE-LYSQYLE---RLK-TFISSEL----------------------------------------- 185
186 KRGNRIGCM------FVRCS---TNPR-----------------------------------------------FTILF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------IG--QMSSF----YIGLG----SRINCNIFSYDYSGYGVSSGKPSE---RNLYSD--IDAA----------------------------------------------W-----------------------------Q--SLRTR-----------------------------------------------------------------------------------------------------------YGISPEH----I-II--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPTVD-----L--------------AS-------------RF--ECAAVILHSPLMSGMRVAF--P-----DTKRTWCFDAFP-----------------------SIEKIGKVMSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTEDE--VIDFSHGLAIYERCPRAVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDVE-LYGQYLE---RLK-QFVSHEL----------------------------------------- 186
187 SRGNRVACM------HVKCTTTVPVSK-----------------------------------------------YTLLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMSSF----YVGLS----ARLGVNIFSYDYSGYGASAGHPTE---KNIYAD--IEAA----------------------------------------------F-----------------------------Q--SLRQR-----------------------------------------------------------------------------------------------------------YSVSPEH----I-IL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPTID-----L--------------AK-------------KY--ECGAVILHSPLLSGLRVAF--P-----DTKRSWCFDVFP-----------------------SIEKIPKVTSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTEDE--VIDFSHGLAIYEQCPRAVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDIE-LYSQYVE---RLR-QFIHNEL----------------------------------------- 187
188 KRGNVIACM------LVRCS---LSSR-----------------------------------------------NTLLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMASF----YIGLG----TRLNCNIFSYDYSGYGASTGRASE---KNIYAD--IDAA----------------------------------------------W-----------------------------L--ALRNR-----------------------------------------------------------------------------------------------------------YAVTPDS----I-IL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVATID-----L--------------AS-------------RY--ECAGVVLHSPLLSGVRVAF--P-----NTNKDICCDPFR-----------------------SIDKIHKVVSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTEDE--VVDISHGITMYEKCLHAVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDVE-LYGQYLE---RLK-KFFSHEI----------------------------------------- 188
189 NRGNKVTCM------YVRCS---PTAK-----------------------------------------------FTLLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMSSF----YIGLG----TRINCNIFSYDYSGYGQSSGKPTE---KNIYAD--IDAA----------------------------------------------W-----------------------------H--SMRTR-----------------------------------------------------------------------------------------------------------YGISPDK----V-LL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPTID-----L--------------AS-------------RF--ECAGVILHSPLMSGMRVAF--P-----ETKKTYCFDVFP-----------------------SIEKCHKISSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTEDE--VIDFSHGLAIYEKSPKAVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDVE-LYGQYLE---RLK-QFVQYDL----------------------------------------- 189
190 RRGNRVACM------YVKIT---DSPE-----------------------------------------------FTILF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMSSF----FIGLG----NRINCNILAYDYSGYGASTGKASE---ANIYSD--AEAA----------------------------------------------W-----------------------------E--TLKTR-----------------------------------------------------------------------------------------------------------FGLRPDQ----V-IL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAATVD-----L--------------AT-------------RH--EVAGVVLHSPLMSGMRVAC--P-----DVRRTWCFDSFA-----------------------SIEKITRVTSPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTDDE--VIDFTHGLALFERAPRTVEPLWVEGA--------------------------------------------------------------------------------------------------------------GHNDVE-LYGQYLD---RLR-KFIQVDI----------------------------------------- 190
191 RRRNRVACT------MIRPL---PNSH-----------------------------------------------FTLLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--QMTSF----LYGLG----FHLNCNVFSYDYSGYGCSTGKPSE---KNLYAD--ITAA----------------------------------------------F-----------------------------E--LLKSE-----------------------------------------------------------------------------------------------------------FGVPKEK----I-IL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPSVD-----L--------------AS-------------RE--DLAALVLHSPLMSGMRVAF--P-----GTTTTWCCDAFP-----------------------SIEKVPRVKCPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTDDE--VIDFSHGVSIYERCPTSVEPLWVPGA--------------------------------------------------------------------------------------------------------------GHNDVE-LHAAYLE---RLR-SFIDMEA----------------------------------------- 191
192 KRQSRIVCM------HIPASSVVSPSQFSSNISSRRGLSGQSRMRSPALSVSCPTLTDEGRFGSAQHNSPHQPTYTVLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------IG--QMAGF----LQSLA----YRFSVNILCYDYSGYGGSSGQRLE---ENLYAD--ADAV----------------------------------------------L-----------------------------N--ELRER-----------------------------------------------------------------------------------------------------------FNVPLNR----I-VL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAPTVE-----L--------------AT-------------KY--KVAGVVLHSPFMSGLRVVC--P-----GTTRRFCFDPFT-----------------------NIDKVSRILSPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIIH-----GTDDE--IIGIDHGRELYSRLTNPLEPAWIEGA--------------------------------------------------------------------------------------------------------------GHNDIE-LFSEYAT---RLD-RFFNEDI----------------------------------------- 192
193 RRGNNIAIL------YMPIN---SSSK-----------------------------------------------LTFLL----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AVD------LG--LMLHF----MYELG----SKLNVNIMCYDYSGYGASSGKPLE---KNLYAD--AECA----------------------------------------------L-----------------------------N--VLRTK-----------------------------------------------------------------------------------------------------------YSVPLNQ----I-VL--Y-G--QS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVPTIH-----L--------------AT-------------LH--RVAAVVLHSPLMSGLRVAF--P-----RLKRNYCCDVFS-----------------------NYVRAPRIISPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIIH-----GTEDE--IIDRVHAQRLYERIPNTLEPLFIRGA--------------------------------------------------------------------------------------------------------------GHNDCE-LYEEYLI---RLE-YLVHVEV----------------------------------------- 193
194 ARGTKVVAF------YLRN----PCAR-----------------------------------------------LTVLY----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AAD------LG--QLYDL----FVQLK----VNLKVNLMGYDYSGYGASTGKPSE---ENTYAD--IEAV----------------------------------------------Y-----------------------------Q--CLETE-----------------------------------------------------------------------------------------------------------YGISQEN----V-IL--Y-G--QS-----------------VG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGPTLH-----L--------------AS-------------RLP-RLRAVVLHSAILSGLRVVC--H------VNFTFCFDIYK-----------------------NVKKIKKVKCPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTDDD--VVNWSHGNELWKLAREPYDPLWIKGG--------------------------------------------------------------------------------------------------------------GHCNLE-LYPDFIR---HLS-KFIREME----------------------------------------- 194
195 RRGNKVTAF------YLRN----PNAR-----------------------------------------------LTLLY----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AAD------LG--QLFDL----FVQLK----VNLRVNLMGYDYSGYGASTGKPSE---YDTYAD--IEAA----------------------------------------------Y-----------------------------E--CLQTD-----------------------------------------------------------------------------------------------------------YGVGQED----L-IL--Y-G--QS-----------------VG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGPTLH-----L--------------AS-------------KLP-RLRGVVLHSGILSGLRVLC--H------VKFKFCCDIYS-----------------------NVNKIKKVKCPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTEDD--VVNWLHGNRLWKMAKEPYEPLWIKGG--------------------------------------------------------------------------------------------------------------GHCNLE-IYPDYIR---HLY-RFIQDME----------------------------------------- 195
196 KRGNQVVAA------YIKN----PTAS-----------------------------------------------LTLLY----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AAD------LG--QMFEL----FSELS----LHLRVNLIGYDYSGYGRSSGKPSE---QNTYSD--IEAV----------------------------------------------Y-----------------------------R--CLEEK-----------------------------------------------------------------------------------------------------------YGVKEQD----V-IL--Y-G--QS-----------------VG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGPTLE-----L--------------AS-------------RLP-NLRAVVLHSAIASGLRVMY--P------VKRTYWFDIYK-----------------------NVEKISFVKCPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTSDD--VVNWSHGKQLFELCKEKYEPLWIKGG--------------------------------------------------------------------------------------------------------------NHCDLE-LYPQYIK---HLR-KFVSAIE----------------------------------------- 196
197 KRGNEIVAM------YVKN----PTAK-----------------------------------------------LTVLF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------ASD------LA--QIFYI----LAEL-----IQLNVNLMGYDYSGYGQSSGKPSE---QDTYAD--IEAA----------------------------------------------Y-----------------------------N--WLRQT-----------------------------------------------------------------------------------------------------------YGTKDER----I-IL--Y-G--QS-----------------VG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGPSLE-----L--------------AS-------------RLP-RLRALVLHSPFLSGLRVMY--P------VKHSFPFDIYK-----------------------NIDKIHLVECPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTDDD--VVNISHGKHLWGLCKEKYEPLWLKGR--------------------------------------------------------------------------------------------------------------GHSDIE-MSPEYLP---HLR-KFISAIE----------------------------------------- 197
198 RRGTDIIAM------YVRC----PKAR-----------------------------------------------LTVLY----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AAD------LG--KMYEL----FIEFS----ARLHVNVMGYDYSGYGRSSGKAGE---ANTFAD--IEAA----------------------------------------------Y-----------------------------K--CLVEV-----------------------------------------------------------------------------------------------------------YGTRGED----I-VL--Y-G--QS-----------------VG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGPTVD-----L--------------AS-------------RLH-HIRAVVLHSPILSGLRVMY--S------VKKTYWFDIYK-----------------------NIEKIPLVKRPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTNDD--VVDCSHGKRLWELSQQKYEPLWIEGG--------------------------------------------------------------------------------------------------------------DHCNLE-TFPVYIR---HLK-KFLSAIEK---------------------------------------- 198
199 RRGNTVAAL------YVRH----PDAA-----------------------------------------------STVLY----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AAD------LG--HLYQL----FLHLS----FSLRVNVLGYDYSGYGQSSGKPSE---QNTYAD--IEAA----------------------------------------------Y-----------------------------K--CLIEN-----------------------------------------------------------------------------------------------------------FDAKEEE----I-IL--Y-G--QS-----------------VG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGPTVD-----L--------------AS-------------RLK-RLRAVVLHSPILSGMRVMY--P------VKRTYWFDIYK-----------------------NIDKIPHVTCPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIIH-----GTADE--VVDWSHGKQLWELCKEKYEPLWLRGG--------------------------------------------------------------------------------------------------------------KHCDLE-LFPEYLR---HLK-KFIHRVQKSPSHR----------------------------------- 199
200 RCGNEIVAV------YVKH----SKAN-----------------------------------------------GTLLY----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AAD------LG--QMFEL----FVELS----NRLRVNLMGYDYSGYGQSTGQASE---CNTYAD--IEAS----------------------------------------------Y-----------------------------K--CLKEK-----------------------------------------------------------------------------------------------------------YGVKDDQ----L-IV--Y-G--QS-----------------VG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGPTVD-----L--------------AS-------------RTP-NLRGVVLQCPILSGMRVLY--P------VKCTYWFDIYK-----------------------NIDKIGSVTCPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTADE--VVDWSHGKRLWELSKEKYEPLWISGG--------------------------------------------------------------------------------------------------------------GHCDLE-LYPDFIR---HLK-KFVVSLG----------------------------------------- 200
201 RRGNEIVAI------YIKH----PKAN-----------------------------------------------GTLLY----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AAD------LG--QMFEL----FIELS----NRLRLNLMGYDYSGYGQSTGKASE---CNTYAD--IDAA----------------------------------------------Y-----------------------------T--CLKEH-----------------------------------------------------------------------------------------------------------YGVKDDQ----L-IL--Y-G--QS-----------------VG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGPTID-----L--------------AS-------------RTP-NLRGVVLHSPILSGMRVLY--P------VKRTYWFDIYK-----------------------NIDKIGAVTCPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTADE--VVDCSHGKQLWELSKEKYEPLWVSGG--------------------------------------------------------------------------------------------------------------GHCNLE-LYPEFIK---HLK-KYVISIS----------------------------------------- 201
202 RRGNEIVGV------YVRN----ARAS-----------------------------------------------ATLLY----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AAD------LG--QMYGL----FVELS----RRLRVNIFGYDYAGYGRSTGKPTE---YNTYAD--IEAA----------------------------------------------Y-----------------------------N--CLKEK-----------------------------------------------------------------------------------------------------------YGVADED----I-IL--Y-G--QS-----------------VG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGPTID-----L--------------AS-------------QLP-NLRAVVLHSPILSGLRVLY--P------VKKTFWFDIYK-----------------------NVDKIGLVNCPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTSDD--VVDCSHGKQLWELCKVKHSPLWLSGG--------------------------------------------------------------------------------------------------------------GHCNLE-LYPDYIR---HLK-KFVSSL------------------------------------------ 202
203 RRGTEIVGM------YVRH----PMAT-----------------------------------------------STLLY----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AAD------LG--QMYEL----FIELS----IHLKVNLMGYDYSGYGQSTGKPSE---HNTYAD--IEAV----------------------------------------------Y-----------------------------K--CLEET-----------------------------------------------------------------------------------------------------------FGSKQEG----V-IL--Y-G--QS-----------------VG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGPTLD-----L--------------AS-------------RLP-QLRAVVLHSPILSGLRVMY--S------VKKTYWFDIYK-----------------------NIDKIPYVDCPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIIH-----GTSDE--VVDCSHGKQLWELCKDKYEPLWVKGG--------------------------------------------------------------------------------------------------------------NHCDLE-HYPEYIR---HLK-KFIATVE----------------------------------------- 203
204 RRGTEIVAM------YVRH----PMAT-----------------------------------------------STLLY----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AAD------LG--QMYEL----FIELS----IHLKVNLMGYDYSGYGQSTGKPSE---HHTYAD--IEAA----------------------------------------------Y-----------------------------K--CLEET-----------------------------------------------------------------------------------------------------------YGAKQED----I-IL--Y-G--QS-----------------VG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGPTLD-----L--------------AA-------------RLP-QLRAAVLHSPILSGLRVMY--P------VKKTYWFDIFK-----------------------NIDKIPLVNCPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTCDE--VVDCSHGKQLWELSKEKYEPLWLEGG--------------------------------------------------------------------------------------------------------------NHCDLE-HYPEYIK---HLK-KFITTVERDLSSRAST-------------------------------- 204
205 KRGTEVVAM------YVRQ----PGAR-----------------------------------------------LTLLY----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AAD------LG--QMYEL----FVELS----SHLNVNLMGYDYSGYGQSSGKPSE---QNTYAD--IEAA----------------------------------------------Y-----------------------------R--CLIET-----------------------------------------------------------------------------------------------------------YGISEEN----I-IL--Y-G--QS-----------------VG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGPTLD-----L--------------AS-------------RSP-HLRAVVLHSPISSGLRVMY--P------VKHTYWFDIYK-----------------------NIDKVPLVKCPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTADE--VVDCSHGRALWELSKVKYEPLWVKGG--------------------------------------------------------------------------------------------------------------NHCNLE-LYPEYIK---HLK-KFVTAIEK---------------------------------------- 205
206 KRGTEVVAM------HVRQ----TGAK-----------------------------------------------LTLLY----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AAD------LG--QMYEL----FVELS----AHLNINLMGYDYSGYGQSSGKPSE---QNTYAD--VEAV----------------------------------------------Y-----------------------------R--CLIET-----------------------------------------------------------------------------------------------------------YAASEEN----I-IL--Y-G--QS-----------------VG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGPTLD-----L--------------AS-------------RLP-RLRAVVLHSPILSGLRVMY--P------VKNTYWFDIYK-----------------------NIDKVPLVRCPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTADE--VVDCSHGRALWELSKVKYEPLWVKGG--------------------------------------------------------------------------------------------------------------NHCNLE-LYPEYIK---HLK-KFVGAIEK---------------------------------------- 206
207 KSGNKVVAT------FWRH----PFAR-----------------------------------------------FTLLY----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AAD------LG--QMVEL----FIELR----AHLRVNIMSYDYSGYGASTGKPSE---FNTYYD--IEAV----------------------------------------------Y-----------------------------S--CLRSD-----------------------------------------------------------------------------------------------------------YGIKQEE----I-IL--Y-G--QS-----------------VG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGPTLH-----M--------------AS-------------RLK-RLRGVVLHSAILSGIRVLY--P------VKMTLWFDIFK-----------------------NIDKIRHVNSQV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTNDE--IVDLSHGKRLWELAKEKYDPLWVKGG--------------------------------------------------------------------------------------------------------------GHCNLE-TYPEYIK---HLK-KFVNAME----------------------------------------- 207
208 KSGNKVIAT------FWKH----PFSR-----------------------------------------------FTLLY----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AAD------LG--QMVDL----FIELR----AHLRVNIMSYDYSGYGASTGKPTE---LNTYYD--IEAV----------------------------------------------Y-----------------------------N--CLRTE-----------------------------------------------------------------------------------------------------------YGIMQEE----M-IL--Y-G--QS-----------------VG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGPTLH-----L--------------AS-------------RVK-RLRGIVLHSAILSGLRVLY--P------VKMTFWFDMYKVSLISLVSGYYYRVSLSNSGILQNIDKIRHVTCPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTKDD--IVNMSHGKRLWELAKDKYDPLWVKGG--------------------------------------------------------------------------------------------------------------GHCNLE-TYPEYIK---HMR-KFMNAME----------------------------------------- 208
209 RAGTRVVAA------FWRH----PAAR-----------------------------------------------LTLLY----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AAD------LG--QMLGL----FMELR----SHLRVNIMCYDYSGYGASTGKPSE---YNTYYD--IEAV----------------------------------------------Y-----------------------------D--CLKKE-----------------------------------------------------------------------------------------------------------YGIEPEE----L-IL--Y-G--QS-----------------VG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGPTLH-----L--------------AS-------------RLE-KLRGVVLHSAILSGIRVLY--P------VKVTLWFDIFK-----------------------NIDKIKQVECPV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVIH-----GTADD--IVDFSHGKRLWELAKEKYEPLWVKGG--------------------------------------------------------------------------------------------------------------GHCNLE-TYPEYIR---HLR-KFVNAME----------------------------------------- 209
210 KHGSTICGI------FLN-----NNAH-----------------------------------------------LTILF----S-------H---------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------AED------IG--DIVPQ----FESKL----KRLGLNMFAYDYSGYGQSTGYPTE---THLYND--VEAA----------------------------------------------Y-----------------------------N--YLISE-----------------------------------------------------------------------------------------------------------LNISKEC----I-IA--Y-G--RS-----------------LG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAASVH-----I--------------AT-------------KR--DLLGLVLQCPLSSIHRVKL--------RLKFTLPYDLFC-----------------------NIDKVHLIKCPI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LFIH-----GKKDK--LLSYHGTEEMITKTKVNTYFMFIDEG--------------------------------------------------------------------------------------------------------------GHNNLDSCFGNKMT--AALV-TFLFV------------------------------------------- 210
211 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HEMLN------K-E---VA-AG-------------TS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTN----I-FV--S-G--LS-----------------QG-----------------------------G-ALAIA-----------------------------------SVLLYPKTLGGCAVFSG-----------------------------------------------------------------------------------------------------------------------------------------S-VPL------------------------------------------------RK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------SFAER----------------------------------------------------------VS-------------------PEARKT--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------VL------------------------------------------------------WFHGM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADG--L----------------V--------------LFEAGHA----------GCA-FLQELG--------------------------M-T--CEFK----------------------------------TYP--T-LGHS------------------------------------------------------------------ 211
212 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MID------R-E---VA-GG-------------IH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDN----I-FV--C-G--FS-----------------QG-----------------------------G-ALTLA-----------------------------------SVLLYPKTLGGGAVFSG-----------------------------------------------------------------------------------------------------------------------------------------W-VPF------------------------------------------------GS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVIER----------------------------------------------------------IS-------------------PEARKT--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------IM------------------------------------------------------WSHGM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADR--V----------------V--------------LFEAGQA----------GPP-FLQSAG--------------------------V-S--CEFK----------------------------------AYP--D-LGH------------------------------------------------------------------- 212
213 ----------------------------------------------------------MKVVTPKPFTFKGGDKAVLLL------------H----------------------------------------------------------------------------------------------------------------------------------------------------------------GFTGN--TA--------------------------------------------------D---VRMLG---------------------------------------------------------------------------------------------------------------------------------------R--YLNER-------------------------------------------------------------------GYTCHAPQYEG--HGVPPEELVHTGPEDWWKNVMDGYEYLKS----EGYESIAAC----G--LS-----------------LG-----------------------------G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFSLKLG--YTVP--------------IKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPMNTLKALQDLIADVRNNVDMIYSPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VQ-----ARHDH--MINTESANIIYNEVETDDKQLKWYEE-------------------------------------------------------------------------------------------------------------SGHVITLDKERDLVHQDVYEFLE----------------------------------------------- 213
214 ----------------------------------------------------------MKLASPKPFTFEGGDRAVLLL------------H----------------------------------------------------------------------------------------------------------------------------------------------------------------GFTGN--SA--------------------------------------------------D---VRMLG---------------------------------------------------------------------------------------------------------------------------------------R--FLEKK-------------------------------------------------------------------GYTCHAPIYKG--HGVPPEELVHTGPEDWWQDVTEAYQLLKD----KGFEKIAVV----G--LS-----------------LG-----------------------------G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFSLKLA--YTTP--------------VLGVVPMCAPMYIKSEETMYQGILAYAREYKKREQKSPEQIEQEMLEFQKTPMNTLKALQQLIADVRNNVDMIYAPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VQ-----ARHDE--MINTDSANIIYNGVESTLKDIKWYED-------------------------------------------------------------------------------------------------------------STHVITLDKERDELHEDVYNFLE----------------------------------------------- 214
215 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSLIKE------Q-M----D-QG-------------IK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSR----I-VL--G-G--FS-----------------QG-----------------------------G-AMSLF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-GIT-GQE-----K--------------------------------------LG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVFGL----------------------------------------------------------SCYMLLSDRIK-NYIPENFPNKK---T--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------FF------------------------------------------------------LAHGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDD--I----------------V--------------PHEFGKRS---------AE--MAK--------------------------ELGLED--VTFN----------------------------------SYK--Y-LSHS------------------------------------------------------------------ 215
216 --KHKICAMELYCEQSIRWLHRDKNRQ------------------------------------------RLRSPNLIIF----S-------Q---------------------------------------------------------P--------------------N------------------------------------------------------------------------------------------------------------------------------------------SSD------LG--CCLMM-DPNFADIA----DFLQCDLLIYDYPGYGVSEGTTNE---KNVYAA--VEAV----------------------------------------------M-----------------------------K--YAMGT-----------------------------------------------------------------------------------------------------------LGYSQDK----I-IL--I-G--FS-----------------LG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAAMVH-----V--------------AE-------------MY--KVAAVVLIAPFTSFFRIVCRRP-----SIIRP-WFDMFP-----------------------SLEKSKGIGSPT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LICH-----GEKDY--IVGHEHGVLLKDTIPD-CELHLLQHA--------------------------------------------------------------------------------------------------------------SHQGIF-CEREMWD---RVE------------------------------------------------- 216
217 SEDSHLVCVKCSPNCYSKNP---EVAN-----------------------------------------------QVVLF----C-------Q---------------------------------------------------------S--------------------S------------------------------------------------------------------------------------------------------------------------------------------SAD------LG--SFLQPNSMNFSTFA----NLFETDVYAFDYSGYGFSSGTQSE---KNMYAD--VRAV----------------------------------------------Y-----------------------------E--HILKT-----------------------------------------------------------------------------------------------------------R--PDKK----I-VV--I-G--YS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTAAVD-----L--------------AA-------------SNPDRLVGVVLIAPLTSALRMFCNNP-----DKETTC------------------------------IDKICHINTRV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LICH-----GDHDQ--RIPMTHGMALYENLKNPVPPLIVHGA--------------------------------------------------------------------------------------------------------------NHHSI--ISGEYIEVFTRIA-SFMRNETLLSCRANQIESSSSKK------------------------- 217
218 ANNNDLVCVKCTPDSYSSNP---AVAE-----------------------------------------------QVVLF----C-------Q---------------------------------------------------------P--------------------N------------------------------------------------------------------------------------------------------------------------------------------SSD------LG--GFLQPNSMNFVTYA----NVFETDLYAFDYSGYGFSSGTQGE---KNVYAD--VRAV----------------------------------------------Y-----------------------------E--KILEM-----------------------------------------------------------------------------------------------------------R--PDKK----I-VV--M-G--YS-----------------IG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTAAVD-----L--------------AA-------------TNPDRLAGVVLIAPFTSGLRLFSSKP-----DKPDTCWADSFK-----------------------SFDKINNIDTRV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LICH-----GDVDE--VIPLSHGLALYEKLKNPVPPLIVHGA--------------------------------------------------------------------------------------------------------------NHHTI--LSGKYIHVFTRIA-NFLRNETLVSCRSAEVDSSQQQQ------------------------- 218
219 -----------------------------------------------------------------ANDGIELAGELTLP----------------------------------------------------------------------R--------------------N------------------------------------------------------------------------------------------------------------------------------------------RSQ-----------------------------------------------------------------------------------------------------------------------------------------------PALA---------VIIHHSGP----------VDRDAYGYLAELLVA-RGYA---VFRFDKRGTGASEGTYG--CCEAQD-----------ALAAYRTAVHQPGID---------------PGRV----FI--I-A--QS-----------------IG-----------------------------T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RYVAD--------------------------L-----FDAYVAAS----PPCGVA----------LL------SNLL--------------------------------GPDEIIAISAPVHVIV------------------A----DSEPE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-----IGPDA--V--------------------------------------------------------------------------------------------------------------------------------------AAH----------NA------HW-----------PYGASLYIAEGAEH---------------------- 219
220 ------------------------MIEIESRELADIPVLHAYPVGQKDTPLP----------------------C-VIF----Y-------H----------------------------------------------------------------------------------------------------------------------------------------------------------------GFT-----S----------------------------------------SS---------------LVYSYFAVALAQAGLRVIMPDAPDHGSRFSGDAARRL-NQFWQILL---Q-SMQE--FTTL----------------------------------------------R-----------------------------A--AIAEE-NW-------------------------------------------L-------LDD--------------------------------------------------------R----L-AV--G-G--AS-----------------MG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTALG---------------------------------------------------------------------------------------------I--TAR------------------------------------------H-----PTVRCTA-----------------S------------------------------------------------------------MMGSGY---------------------------------------------------------------------------------------------------------------------------------------------------------F--TSLAR---SLFPPL--------IPETAAQQNEFNNIV--APLAEWEATNHLEQLSDR----------------------------P-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LW-H-----GLDDD--VVP-----------------------------ADES--------------------------L------------RLQQALS--ETGRDKLLTCSWQPGV------------------------------------RHRITP-----EALDAAVTFFRQHL-------------------------------------------- 220
221 ------------------------MIQIENQTVSGIPFLHIVKEENRHRAVP----------------------L-VIF----I-------H----------------------------------------------------------------------------------------------------------------------------------------------------------------GFT-----S----------------------------------------AK---------------EHNLHIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVL---N-EIEE--IGVL----------------------------------------------K-----------------------------N--HFEKE-GL-------------------------------------------I-------DGG--------------------------------------------------------R----I-GL--A-G--TS-----------------MG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ITTLG---------------------------------------------------------------------------------------------A--LTA------------------------------------------Y-----DWIKAGV-----------------S------------------------------------------------------------LMGSPN---------------------------------------------------------------------------------------------------------------------------------------------------------Y--VELFQ---QQIDHIQSQGIEIDVPEEKVQQ-----LM--KRLELRDLSLQPEKLQQR----------------------------P-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FW-H-----GAKDK--VVPY-APTR-----------KFY-DT-IKSHYSEQP--------------------------E------------RLQFIGD--EN-------------A------------------------------------DHKVPR-----AAVLKTIEWFETYL-------------------------------------------- 221
222 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K----L-GI--G-G--FS-----------------MG-----------------------------A-SAALH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-AACYAHG-----K---------------F-------------STGIPYPITLS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVISL----------------------------------------------------------SGWLPCSRTLRGKMESSSMSARRAASL--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------IL------------------------------------------------------LCHGR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADE--V----------------V--------------SYKNGERS---------TEF-LRS---------------------------SGFSY--LTFK----------------------------------SYN--G-LGH------------------------------------------------------------------- 222
223 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R----L-GI--G-G--FS-----------------MG-----------------------------A-ATALH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-AACYAHG-----R---------------F-------------TNGAAYPISLS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVIGL----------------------------------------------------------SGWLPCSRTLRTKMESSQTAIRRAAAL--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------IL------------------------------------------------------LSHGR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADE--V----------------V--------------TYRNGERS---------AEF-LRM---------------------------SGFSY--LNLK----------------------------------TYN--G-LGH------------------------------------------------------------------- 223
224 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K----V-GI--G-G--FS-----------------MG-----------------------------A-AIALY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-TTCYALG-----R---------------Y-------------GTGHAYTINLR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATVGL----------------------------------------------------------SGWLPGWRSLRSKIESSNEVARRAASI--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------IL------------------------------------------------------LAHGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDD--V----------------V--------------PYRFGEKS---------AHS-LAM---------------------------AGFRQ--TMFK----------------------------------PYE--G-LGH------------------------------------------------------------------- 224
225 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K----L-GV--G-G--FS-----------------MG-----------------------------A-ATALY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-GTCFAHG-----K---------------Y-------------GNGNPYPVNLS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------LAVGL----------------------------------------------------------SGWLPCARSLKNKIESSQEAAQKASLL--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------LL------------------------------------------------------LCHGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADD--V----------------V--------------LYKHGERS---------VDA-LKS---------------------------TGFSN--VVFK----------------------------------SYN--R-LGH------------------------------------------------------------------- 225
226 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K----L-GV--G-G--FS-----------------MG-----------------------------A-ATSLY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-ATCFALG-----K---------------Y-------------GNGNPYPINLS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------AIIGL----------------------------------------------------------SGWLPCAKTLAGKLEEEQIKNRAAS-L--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------IV------------------------------------------------------VCHGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADD--V----------------V--------------PFKFGEKS---------SQA-LLS---------------------------NGFKK--VTFK----------------------------------PYS--A-LGH------------------------------------------------------------------- 226
227 -------------------------------------------------------------------MNYKN--------------------------KFIDRQVE---------------------------------NFPAVVILGGG--------------------G------------------------------------------------------------------------------------------------------YKEIDTYEIIPVARNLNFLSKGYHSFIL-----DYSIGENSSY----------------------------PNPLIDVYEAIIFIKQKAEEWHINK---D----------------------------------------------------------------------------------K-----------------------------------------------------------------------------------------------------------------------------IILI----G--FS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGLCGTQ--WKLDSFETLLN------------NKKKN--FKPNAMVLCYPIT-------SMELLRKEKGENVGTNWGKILQDNKEKSDVIKSI------------DQDTIPTFIWH-----TRTDG--VVSSTQSIKMMEKMNEF---------NIPY----E-----------------------------------------------------------------------------------------------------SH----IFFDGFHGLSTNDTLTNYKFSVQDGYQP----------------------------------- 227
228 -------------------------------------------------------------------MNIKNIIFILIFLLLLILVSPRIKFKNEFSKKLIPKNIEEIDNYLLKEELQFNLESNTKKEIIWYKEKAQKTNYSVVYIHGFG--------------------A------------------------------------------------------------------------------------------------------SKN----EIYPVPNN---IAKALNANIFFTRLKGHGINNKNAFRGIT-----------------------TQDWLRDIDEAI----------NIGKLIGD----------------------------------------------------------------------------------K-----------------------------------------------------------------------------------------------------------------------------LVLI----G--TS-----------------NG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTASIWALANYPNEISSAVLISPNIFPYDKRTNIVYYPWGRQIAYLITGGYNKFETKEYKRKEH-PTIKSHSSRV-----QHVDAIIAMMGLVTLLNSYNFNEIKIPLIITH-----TPNDH--TVDPI-------KINEFIKNYGGEKKDIPIILLEN-----------------------------------------------------------------------------------------------------SHAHLPIGNQSYKSAQNTSYFTKYVFDFINKINK----------------------------------- 228
229 FLNFRRLPNTDYNDLASNNVKSIGRSLHLPGKSGRIGVWHILPNKLSLEWRTEGK----HPTERDFDDMMRDSENQIIFYAHGNSFDRTFYH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVEMYNLLSDCN-YHVVCFD------------YRGYGDSEGTPTE---------------------------------------KGIVEDTKTVYE-------------------------------------------------------------------------------WLKEN------------------------------------------------------CGK-------------------------------------------------------------TPVI--VWG--HS-----------------MG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGVSCKLVQDL---------SREQQPPCGL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E----SPFNNLKDAVTNHPIFTVFSWMNDFMVDHIIIRPLNSVGLTMRSDKRIRLVSCPIIILH-----AEDDKILPVKLGRALYEAAKDAERDIK------IREFSSDYGL----------------------------------------------------------------------------------------------------GHKF----------------------------ICRYPELPEIIEEFV---GSVT--------------- 229
230 --------------------ETREPVVLENQGQKIFGVIHI----PEKTPAP----------------------F-VLF----C-------H----------------------------------------------------------------------------------------------------------------------------------------------------------------GFT-----G----------------------------------------TK------V-E---PH-RIFVKTAEALTREGIGALRIDF-----RGSGDSE----GSFKDMTV---EGEVSD--AMIA----------------------------------------------I-----------------------------D--YLARS-NL-------------------------------------------V-------DKE--------------------------------------------------------K----I-GI--L-G--LS-----------------MG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVASI---------------------------------------------------------------------------------------------T--SGR------------------------------------------N-----SLIKSCV-----------------L------------------------------------------------------------WSAVCH---------------------------------------------------------------------------------------------------------------------------------------------------------F--DIFFNRSPEEVSRIKDYGDFIDLGGNPVGKEFLSEIVNIKPL---------EEIKKRSI--------------------------P-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-H-----GGGDI--VVPI-QHAY-----------DYF-NG-LK---DTHK--------------------------V------------KLEII----EN-------------A------------------------------------DHTFNSIEWEEKVIEKTIKWFKE---------------------------------------------- 230
231 --------------------ENREPVVLKNQGQKIFGVIHI----PEKTPAP----------------------F-VLF----C-------H----------------------------------------------------------------------------------------------------------------------------------------------------------------GFT-----G----------------------------------------TK------I-E---PH-RIFVKTAEALAKEGIGALRIDF-----RGSGDSE----GSFKDMTV---EGEVSD--AMVA----------------------------------------------I-----------------------------E--YLSQN-NL-------------------------------------------V-------DKE--------------------------------------------------------K----I-GI--L-G--LS-----------------MG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVASI---------------------------------------------------------------------------------------------T--SGR------------------------------------------N-----PLIKSCV-----------------L------------------------------------------------------------WSAVCH---------------------------------------------------------------------------------------------------------------------------------------------------------F--DIFFNRSPEEVSRIKDYGDFIDLGGNPVGKKFLSEIVNIKPL---------EEIKKRSI--------------------------P-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-H-----GSGDM--VVPI-QHAY-----------DYF-NG-LK---DTHK--------------------------V------------KLEII----EG-------------A------------------------------------DHTFNSIEWEEKVIEKTVNWFKE---------------------------------------------- 231
232 ---------------------------------------------------------IQGVLIYPLNYEQGKKYPLITY----I-------H---------------------------------------------------------G--------------------G-------------------------------------------PEAAVQNGWETGYGSWGQFA---------------AAKDFF-----V----------------------------------------FM------P-N---YR---ASS---------------------GRGVEFTMMGFG-----DLA---GKEFED--VIDG----------------------------------------------I-----------------------------D--YLIQK-GLV--------------------------------------------------DKN--------------------------------------------------------K----V-GI--G-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-FSAWAAT-----K--------------YT-------------DRFAASVVFVGISNQISKRNTTDIPY-EDY-----------YVHWGFWTHENEQL--VWE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R---SPVRYAH---------LSKTP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GKEDL--RVHP--SQSLELYRA--LKLHGKAPVRL-----------------------------------------------------------------------VFYPG-------------------------------QGHGNSKNTSRYDYLVRTL--------------------------------------------------- 232
233 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VDA------E-I----K-AG-------------VP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IGN----I-VI--G-G--FS-----------------QG-----------------------------G-SVALY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-ALT-STL-----Q--------------------------------------YG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVVAF----------------------------------------------------------SCWLPLHTKFM-SSPTLLTMPKD---V--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------VF------------------------------------------------------QCHGL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDY--T----------------I--------------PFAMGKLT---------HEL-LKT---------------------------FQLSK--CELN----------------------------------CYP--Q-LSH------------------------------------------------------------------- 233
234 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIQA------E-V----D-SG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENR----I-VL--G-G--FS-----------------QG-----------------------------G-AISVL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-MLT-TKR-----K--------------------------------------LA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVVAL----------------------------------------------------------STWVPLNHKIV--QM-MSEHAKD---I--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------VF------------------------------------------------------WGHGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDP--V----------------V--------------DYRFGQRSVDFLVQKCGYKL-LSQ--------------------------GTTFARPGIRFE----------------------------------SYP--G-MPHS------------------------------------------------------------------ 234
235 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIEH------E-M----K-NG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANR----I-VL--G-G--FS-----------------QG-----------------------------G-ALSLY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-ALT-CPH-----P--------------------------------------LA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIVAL----------------------------------------------------------SCWLPLHRAFP--QAA-NGSAKD---L--------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------IL------------------------------------------------------QCHGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDP--M----------------V--------------PVRFGALT---------AEK-LRS--------------------------VVTPAR--VQFK----------------------------------TYP--G-VMH------------------------------------------------------------------- 235
236 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIEH------E-M----K-NG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANR----I-VL--G-G--FS-----------------QG-----------------------------G-ALSLY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-ALT-CPH-----P--------------------------------------LA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIVAL----------------------------------------------------------SCWLPLHRAFP--QAA-NGSAKD---L--------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------IL------------------------------------------------------QCHGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDP--M----------------V--------------PVRFGALT---------AEK-LRS--------------------------VVTPAR--VQFK----------------------------------TYP--G-VMH------------------------------------------------------------------- 236
237 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIEH------E-M----K-NG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANR----I-VL--G-G--FS-----------------QG-----------------------------G-ALSLY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-ALT-CPH-----P--------------------------------------LA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIVAL----------------------------------------------------------SCWLPLHRAFP--QAA-NGSAKD---L--------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------IL------------------------------------------------------QCHGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDP--M----------------V--------------PVRFGALT---------AEK-LRS--------------------------VVTPAR--VQFK----------------------------------TYP--G-VMH------------------------------------------------------------------- 237
238 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIEH------E-M----K-NG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANR----I-VL--G-G--FS-----------------QG-----------------------------G-ALSLY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-ALT-CPH-----P--------------------------------------LA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIVAL----------------------------------------------------------SCWLPLHRAFP--QAA-NGSAKD---L--------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------IL------------------------------------------------------QCHGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDP--M----------------V--------------PVRFGALT---------AEK-LRS--------------------------VVTPAR--VQFK----------------------------------TYP--G-VMH------------------------------------------------------------------- 238
239 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M----K-NG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNR----I-IL--G-G--FS-----------------QG-----------------------------G-ALSLY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-ALT-CQH-----Q--------------------------------------LA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIVAL----------------------------------------------------------SCWLPLHKAFP--QAASNGVNKD---I--------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------IL------------------------------------------------------QCHGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDP--M----------------I--------------PVRFGALT---------AEK-LKS--------------------------VVTPAK--VQFK----------------------------------TYP--G-VMH------------------------------------------------------------------- 239
240 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VIEH------E-I----R-NG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANR----I-IL--G-G--FS-----------------QG-----------------------------G-ALSLY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-ALT-CQH-----Q--------------------------------------LA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIVGL----------------------------------------------------------SCWLPLHKTFP--QAASNSMNKD---T--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------IL------------------------------------------------------QCHGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDP--M----------------I--------------PVRFGALT---------SEK-LKC--------------------------MVNPSK--IQFR----------------------------------TYP--G-VMH------------------------------------------------------------------- 240
241 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EN---VKALIEQ------E-V----K-NG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SHR----I-IL--G-G--FS-----------------QG-----------------------------G-ALSLY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-ALT-TQQ-----K--------------------------------------LA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTAL----------------------------------------------------------SCWLPLRASFP--QGPISGVNRD---I--------------------------------------------------------------------------------------------------------------------------------------------------------------------S-------------------------------IL------------------------------------------------------QCHGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CDP--L----------------V--------------PLMFGSLT---------VEK-LKT--------------------------LVNPAN--VTFK----------------------------------TYE--G-MMH------------------------------------------------------------------- 241
242 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EN---IKALIDQ------E-V----K-NG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNR----I-IL--G-G--FS-----------------QG-----------------------------G-ALSLY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-ALT-TQQ-----K--------------------------------------LA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTAL----------------------------------------------------------SCWLPLRASFP--QGPIGGANRD---I--------------------------------------------------------------------------------------------------------------------------------------------------------------------S-------------------------------IL------------------------------------------------------QCHGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CDP--L----------------V--------------PLMFGSLT---------VEK-LKT--------------------------LVNPAN--VTFK----------------------------------TYE--G-MMH------------------------------------------------------------------- 242
243 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EN---VKALIEQ------E-V----K-NG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNR----I-VL--G-G--FS-----------------QG-----------------------------G-ALSLY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-ALT-TQQ-----K--------------------------------------LA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTAL----------------------------------------------------------SCWLPLRTSFP--QGPISGVNRD---I--------------------------------------------------------------------------------------------------------------------------------------------------------------------S-------------------------------IL------------------------------------------------------QCHGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CDF--L----------------V--------------PLTFASLT---------AEK-LKT--------------------------LVNPAN--VTFK----------------------------------TYE--G-MMH------------------------------------------------------------------- 243
244 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EN---VKALIEQ------E-M----K-NG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNR----I-IL--G-G--FS-----------------QG-----------------------------G-ALSLY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-ALT-TQQ-----K--------------------------------------LA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVTAL----------------------------------------------------------SCWLPLRASFP--QGPISGVNRD---I--------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------IL------------------------------------------------------QCHGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CDP--L----------------V--------------PLMIASLT---------SEK-LKM--------------------------LVNPSN--VTFK----------------------------------TYQ--G-MMH------------------------------------------------------------------- 244
245 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EN---VKALIEQ------E-V----R-NG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNR----I-IL--G-G--FS-----------------QG-----------------------------G-ALSLY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-ALT-THQ-----Q--------------------------------------LG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIVAL----------------------------------------------------------SCWLPLRTSFP--QGPINCVNKD---I--------------------------------------------------------------------------------------------------------------------------------------------------------------------S-------------------------------IL------------------------------------------------------QCHGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDP--L----------------V--------------PLMFGSVT---------SET-LKT--------------------------MINPGN--VTFK----------------------------------TYS--G-MMH------------------------------------------------------------------- 245
246 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EN---VKALIDQ------E-V----K-NG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNR----I-IL--G-G--FS-----------------QG-----------------------------G-ALSLY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-ALT-THQ-----K--------------------------------------LA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVVAL----------------------------------------------------------SCWLPLRTSFV--QGAV-GVNKE---I--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------VL------------------------------------------------------QCHGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CDP--L----------------V--------------PLMFGSLT---------VEK-LKS--------------------------MINPAN--ITFR----------------------------------TYS--G-MMH------------------------------------------------------------------- 246
247 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EN---VKALIDQ------E-V----K-NG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SHR----I-VL--G-G--FS-----------------QS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VISKNKD---I--------------------------------------------------------------------------------------------------------------------------------------------------------------------S-------------------------------VL------------------------------------------------------QCHGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADP--L----------------V--------------PLIFGQLT---------VEK-LKS--------------------------MLKPSN--VTFK----------------------------------TYS--G-MTH------------------------------------------------------------------- 247
248 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KN---VHDAIEE------I-E----K-GG-------------TP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNR----I-LL--G-G--FS-----------------QG-----------------------------G-SLAAF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-GLT-YPK-----P--------------------------------------LA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLLLL----------------------------------------------------------SCWVPLHDSLM---NESNDVNKV---I--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------IL------------------------------------------------------QCHGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDM--M----------------V--------------KYLYGQKS---------AEL-LSS--------------------------L-NPSN--HTFK----------------------------------TYN--G-LGH------------------------------------------------------------------- 248
249 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDR----I-LV--G-G--FS-----------------QG-----------------------------G-VVALY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-LLT-YEK-----K--------------------------------------LA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GCMGL----------------------------------------------------------STYMPLHKKFP---SMCNEINKA---T--------------------------------------------------------------------------------------------------------------------------------------------------------------------E-------------------------------IF------------------------------------------------------LAHGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADP--V----------------V--------------KYNYGVMT---------SSL-LKG--------------------------YYK--N--TTLN----------------------------------SYS--G-MAH------------------------------------------------------------------- 249
250 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VRDLISA------E-L----N-ND-------------IA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNR----I-II--G-G--FS-----------------QG-----------------------------G-AIALN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-ALT-YEK-----K--------------------------------------LG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIIGL----------------------------------------------------------STFLEI------------NVNKD---C--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------IF------------------------------------------------------QGHGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CDP--L----------------V--------------NLRFGLMT---------KQI-LSS--------------------------F----NPNVNFV----------------------------------TYP--G-MMH------------------------------------------------------------------- 250
251 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIEE------E-E----K-AG-------------IS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANR----I-MI--G-G--FS-----------------QG-----------------------------G-AVALH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-ALA-TDQ-----K--------------------------------------LA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVVGL----------------------------------------------------------STWLPLHRKLD--QVKKSDHIKE---M--------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------IF------------------------------------------------------QAHGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDP--L----------------V--------------PFRWGEIT---------SKV-LAS--------------------------MCA--N--YSFH----------------------------------NYP----MAH------------------------------------------------------------------- 251
252 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIIKT------E-M---DE-HN-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNR----I-ML--G-G--FS-----------------MG-----------------------------G-ALALY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-ALT-HPQ-----Q--------------------------------------LG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVIAL----------------------------------------------------------SSYLPLHKAFATGEGGISLTAQK---C--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------IF------------------------------------------------------QAHGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDP--M----------------L--------------PFQFGQMS---------NML-LQN--------------------------ARKDLNLTTEFK----------------------------------PYQ--G-MGH------------------------------------------------------------------- 252
253 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------INQLIEQ------E-I----L-SG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDR----I-IL--A-G--FS-----------------QG-----------------------------G-AMSLY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-GLR-YSK-----P--------------------------------------LS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIIAL----------------------------------------------------------STYLPLANHLP--KE-SRAANRS---I--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------IF------------------------------------------------------IAHGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADP--V----------------L--------------PIILGKQT---------AHL-LKE--------------------------LGY--A--VEWH----------------------------------EY---S-MEHQ---------V-------------------------------------------------------- 253
254 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HELIDA------E-L----A-LG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDR----I-LI--G-G--FS-----------------QG-----------------------------C-MVSLY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-GLT-YPK-----R--------------------------------------LA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIMGH----------------------------------------------------------SGFLPLASKFP---SALSRVAKE---I--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------IL------------------------------------------------------LTYMT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDP--I----------------V--------------PSVLSSAS---------AKYLINN----------------------------------LQLKC------------------------------LDRPFE--G-DAHS------------------------------------------------------------------ 254
255 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVAE------E-E----S-HG-------------IA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNR----I-VI--G-G--FS-----------------QG-----------------------------G-AVSLY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-ALT-DDR-----P--------------------------------------YA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVLAL----------------------------------------------------------STWMPLHQTFK--TD-G-VSKKP---M--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------LL------------------------------------------------------QCHGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDN--I----------------L--------------PFSLGQMT---------HNL-LQT--------------------------QVS--S--PEFH----------------------------------KYP--G-LGH------------------------------------------------------------------- 255
256 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVAD------E-E----S-AG-------------IA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNR----I-II--G-G--FS-----------------QG-----------------------------G-AVALH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-ALT-LAK-----P--------------------------------------LA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVIGL----------------------------------------------------------STWLPLHDQFP--GA-I-KGNTN---T--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------IL------------------------------------------------------QCHGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADP--M----------------V--------------QFQFGEMT---------YQN-LKA--------------------------MNC--R--VEFK----------------------------------QYK--G-MSH------------------------------------------------------------------- 256
257 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIAE------E-V----N-SG-------------LD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSR----I-IL--G-G--FS-----------------QG-----------------------------G-TMSLL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-GLT-SER-----K--------------------------------------LG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLVVL----------------------------------------------------------SGWLPLRNKFK---TMASRHAPS---I--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------IF------------------------------------------------------WGQGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDT--L----------------V--------------QPKFASDSAEFVKKEIGTPV-ASS--------------------------QTSPNG--LAFK----------------------------------MYR--G-LAHS------------------------------------------------------------------ 257
258 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SHR----I-IV--G-G--FS-----------------QG-----------------------------G-AVAWM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-GLT-TKR-----K--------------------------------------LA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLFIL----------------------------------------------------------SSYVPLRRKVE---EFASPISKT---L--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------IW------------------------------------------------------WGHGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HDA--Q----------------V--------------QYEFSMYSAQKVASDVGIEF-VRSKEPLTPQ-----------------DAKEDKEKVRLRFA----------------------------------SYE--E-LGH------------------------------------------------------------------- 258
259 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIEE------E-I----K-NG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AER----I-IL--S-G--FS-----------------QG-----------------------------G-ALTLY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-GYQ-SKH-----K--------------------------------------LA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALITL----------------------------------------------------------SGFSP-SLSLP--SK-IKPENKD---I--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------LT------------------------------------------------------MFHGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDK--V----------------V--------------NCKWGELS---------HKSYLKV--------------------------GIK--N--SQFI----------------------------------SIT--N-LDH------------------------------------------------------------------- 259
260 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IETIIKH------E-M---EE-EK-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AER----I-II--G-G--FS-----------------QG-----------------------------A-ALSLY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-FYSQTET-----K--------------------------------------LG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GCIAL----------------------------------------------------------SGYLPLATKFV-----ANSLNKE---Q--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------LL------------------------------------------------------MIHGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CDQ--V----------------V--------------RHQWGKLS---------FDH-LKS--------------------------QGI--N--GEFI----------------------------------TLK--G-LGH------------------------------------------------------------------- 260
261 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIE------E-Q---VA-QG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YER----I-WI--G-G--FS-----------------QG-----------------------------A-ALTMG-----------------------------------TALSFPHRLGGFLSFSG-----------------------------------------------------------------------------------------------------------------------------------------P--PS------------------------------------------------YR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------WLEHT----------------------------------------------------------VS-------------------DANTGA--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------VF------------------------------------------------------QSHGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDE--V----------------F--------------PSSGAEAV---------HRS-FTSQYG--------------------------FKN--HRLK----------------------------------IYD--G-LGHS------------------------------------------------------------------ 261
262 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HELIAT------E-A----D-LG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNR----I-LL--G-G--FS-----------------QG-----------------------------A-VISLL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-SLT-SES-----K--------------------------------------YA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVVAL----------------------------------------------------------SGYLALRNEIS---ELKKTINDT---T--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------FF------------------------------------------------------MAHGH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDE--V----------------V--------------KYEYGKLS---------SEY-LKN--------------------------QLKL-N--VDFK----------------------------------TYH--G-MGHS------------------------------------------------------------------ 262
263 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R----T-YL--F-G--FS-----------------QG-----------------------------A-ILSMA---LAWRIPEHLAGVI----------------------------A------------------------------------------------------------------------------------------------------------------------------------------------A-NGYLD--------------------------------------PALTTQPPAA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIARL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------IL------------------------------------------------------QLHGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YDE--V----------------I--------------PVEQARAT---------RDV-LAQYAPRHRY-----------HEDP---------------------------------------------------------VGHS---------L-------------------------------------------------------- 263
264 ----------------------------------KVPAYFVKPKSAKGP---Y---------------------PAVLF----Q-------H---------------------------------------------------------S--------------------H---------------------------------------------------------------------------------GGQ-----YDRGKSELIEGADYLKAPSFFRELTSL--------------------------------GYGVLAIDH--------WGFGDRQGKTESEIF-KEMLLTGRVMWG---MMIYDSLRALD--------------------------------------------------------------------------------YLQSR-P----------------------------------------------------DVK------------------------------------------------------PDR----I--G--TIG--MS-----------------MG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-MA-----------------------------------------WWTAA-----------LDDRIKVCVDLCSQVD-HHVLMTTQNLDRHGFYYYVPS--LAK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HFS------------------ASEIQSMIAPRP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------HL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SL-V-----GVHDR--LTP--AEGV-----------NKIEEE-LTAV--------YAGQEASDCYRVVRSAS--------------------------------------------------------------------------------GHF------------------------------------------------------------------ 264
265 ----------------------------DLNGHEKAPAYFVKPKKTEGP---C---------------------PAVLF----Q-------H---------------------------------------------------------S--------------------H---------------------------------------------------------------------------------GGQ-----YDRGKSELIEGADYLKTPSFSDELTSL--------------------------------GYGVLAIDH--------WGFGDRRGKAESEIF-KEMLLTGKVMWG---MMIYDSLSALD--------------------------------------------------------------------------------YMQSR-S----------------------------------------------------DVQ------------------------------------------------------PDR----I--G--TIG--MS-----------------MG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-MA-----------------------------------------WWTAA-----------LDDRIKVCVDLCSQVD-HHVLIKTQNLDRHGFYYYVPS--LAK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HFS------------------ASEIQSLIAPRP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------HL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SL-V-----GVHDR--LTP--AEGV-----------DKIEKE-LTAV--------YAGQGAADCYRVVRSAS--------------------------------------------------------------------------------GHFETAVIRHEAVRFL----------------------------------------------------- 265
266 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VNEMLVR------E-L----A-AG-------------VP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LNR----I-VV--G-G--FS-----------------MG-----------------------------G-ALAMH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-GYH-LNR-----D--------------------------------------LG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVFAI----------------------------------------------------------SSFLNTGSIVY---DSLEGVAQDEHLP--------------------------------------------------------------------------------------------------------------------------------------------------------------------E-------------------------------LL------------------------------------------------------MMHGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDT--L----------------V--------------PPEWGQTT---------FDE-LAK------------------------------LGVRGQF------------------------------------------VPH------------------------------------------------------------------- 266
267 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIDD------E-V----K-SG-------------IK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNR----I-LV--G-G--FS-----------------MG-----------------------------G-CMAMH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-AYR-NHQ-----D--------------------------------------VA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVFAL----------------------------------------------------------SSFLNKTSAVY---QALQ--KSDGVLP--------------------------------------------------------------------------------------------------------------------------------------------------------------------E-------------------------------LF------------------------------------------------------QCHGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADE--L----------------V--------------LHCWGEET---------NTM-LKS------------------------------LGVSTQFH----------------------------------SFP--G-LCH------------------------------------------------------------------- 267
268 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIDD------E-V----K-SG-------------IK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNR----I-LV--G-G--FS-----------------MG-----------------------------G-CMAMH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-AYR-NHQ-----D--------------------------------------VA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVFAL----------------------------------------------------------SSFLNKTSAVY---QALQ--ESDGVLP--------------------------------------------------------------------------------------------------------------------------------------------------------------------E-------------------------------LF------------------------------------------------------QCHGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADE--L----------------V--------------LHSWGEET---------NSM-LKS------------------------------LGVSTKFH----------------------------------SFP--G-VYH------------------------------------------------------------------- 268
269 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIDD------E-V----K-SG-------------IK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNR----I-LI--G-G--FS-----------------MG-----------------------------G-CMAMH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VYR-NHQ-----D--------------------------------------VA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVFAL----------------------------------------------------------SSFLNKTSAVY---QALQ--ESDGVLP--------------------------------------------------------------------------------------------------------------------------------------------------------------------E-------------------------------LF------------------------------------------------------QCHGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADE--L----------------V--------------PHSWGEET---------NSV-LKS------------------------------LRVSTKFH----------------------------------SLP--G-VYH------------------------------------------------------------------- 269
270 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LTSLIDD------E-V----K-NG-------------IK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNR----I-LL--G-G--FS-----------------MG-----------------------------G-GMAMH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-AYR-YHQ-----D--------------------------------------VA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVFAL----------------------------------------------------------SSFLNKNSVVY---QALK--KEGQEVP--------------------------------------------------------------------------------------------------------------------------------------------------------------------E-------------------------------LF------------------------------------------------------QCHGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADE--L----------------V--------------LYSWGEET---------NKM-LTS------------------------------LGVTTTFL----------------------------------SLP--N-LYH------------------------------------------------------------------- 270
271 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LINN------E-M----K-NG-------------IT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDR----I-LI--G-G--FS-----------------MG-----------------------------G-GMAMH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-AYR-FHQ-----D--------------------------------------LA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVFAL----------------------------------------------------------SSFLNKDSAVY---EALK--RNESVLP--------------------------------------------------------------------------------------------------------------------------------------------------------------------E-------------------------------LF------------------------------------------------------QCHGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADE--L----------------V--------------LYSWGEET---------NKM-LKS------------------------------LGVPTSLH----------------------------------TFP--N-LNH------------------------------------------------------------------- 271
272 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EL---LGELINS------E-V----R-EG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KHR----I-IV--G-G--FS-----------------MG-----------------------------G-TMALH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-GYR-LHR-----D--------------------------------------LA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVFAF----------------------------------------------------------SSFLNENSYVY---QKLK--ENPGISP--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------LL------------------------------------------------------QCHGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDP--L----------------V--------------LPAWGKAT---------QKE-LKK------------------------------LGVSCQYH----------------------------------VFK--H-MFH------------------------------------------------------------------- 272
273 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DR---IHQLIED------E-V----R-QG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YHR----I-II--G-G--FS-----------------MG-----------------------------G-AMALH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-GYR-YSR-----S--------------------------------------LG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIFAL----------------------------------------------------------SSFVPKDSAVF---KELH--SYKRSPP--------------------------------------------------------------------------------------------------------------------------------------------------------------------S-------------------------------AI------------------------------------------------------VMSGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDE--L----------------V--------------KFEWGVAV---------ANT-LKS------------------------------LGIDCQFQ----------------------------------MFE--G-LQH------------------------------------------------------------------- 273
274 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EE---ISKVIQQ------E-V----D-QG-------------IP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RNK----I-IV--G-G--FS-----------------MG-----------------------------G-CLALH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-AYR-FQR-----E--------------------------------------LG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVFAL----------------------------------------------------------SAFLNNNSKVY---QDLA--SPDSRRP--------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------LF------------------------------------------------------QCHGQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VDP--L----------------V--------------LYEWGETT---------KDQ-LTR------------------------------AGVTCQFQ----------------------------------RYP--R-LYH------------------------------------------------------------------- 274
275 ---------------QHVRLYTICYLSNGLRVKGLLAEPAEPGQYDGFLYLRGGIKSVGMVRPGRIIQFASQGFVVFAP------------F-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YR----------------------------------------------GNQGGEGNED----------------------------------------------------F-----------------------------A-------------------------------------------------------------GEDREDAFSAFRLLQQH---------------------------PNVKK---------DR----I-HI--F-G--FS-----------------RG-----------------------------G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IMG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ML-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAIEMGGQAASFVSWGGVSDMILTY---------------EERQDLRRMMKRVIGGTPKKVPEEYQWRTP------FDQVNKIQAPVLLIH-----GEKDQ--NVSIQHSYLLEEKLKQLHKPVETWYY-----------------------------------------------------------------------------------------------------------STFTHYFPPKENRRIVRQLTQWMKNR---------------------------------------------- 275
276 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NED----------------------------------------------------F-----------------------------A-------------------------------------------------------------GEDREDAFSAFRLLQQH---------------------------PNVKK---------DR----V-HI--F-G--FS-----------------RG-----------------------------G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IMG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ML-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAIEMGGQAASFVSWGGVSDMILTY---------------EERQDLRRMMKRVIGGTPKKVPEEYQWRTP------FDQVNKIQAPVLLIH-----GEKDQ--NVSIQHSYLLEEKLKQLHKPVETWYY-----------------------------------------------------------------------------------------------------------STFTHYFPPKENRRIVRQLTQW-------------------------------------------------- 276
277 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NED----------------------------------------------------F-----------------------------A-------------------------------------------------------------GEDREDAFSAFRLLQEH---------------------------PKVKA---------ER----V-HI--F-G--FS-----------------RG-----------------------------G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IMG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAIEMGKSAASFVSWGGVSDMFLTY---------------EERKDLRRMMKRVIGGTPKKVPEEYERRSP------FDQTNRIQAPVLLIH-----GEKDQ--NVSIQHSYLLEDKLKQLHKPVETWYF-----------------------------------------------------------------------------------------------------------SGFTHYFPPQQNRRIVRELTQW-------------------------------------------------- 277
278 ---------------------------------------------------------------------ASQGFVVFAP------------Y-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YR----------------------------------------------GNQGGEGNED----------------------------------------------------F-----------------------------A-------------------------------------------------------------GEDREDAFSAFRLLQEH---------------------------PNVRE---------GR----I-HI--F-G--FS-----------------RG-----------------------------G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IMG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAIEMGHQAASLVSWGGVSDMALTY---------------EERKDLRRMMKRVIGGTPKKVPDEYRWRSP------FEKADRIQAPVLLIH-----GENDE--NVSIEHARMIEDKLKETGKPVETWYY-----------------------------------------------------------------------------------------------------------SGFTHYFPPQENRRIVRRLAEW-------------------------------------------------- 278
279 --------------------------------------------------------------------MAEGKMPPMIWVMLDEHLPTGTHE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDNSVNNGPWG-----------------------------------------------SALVEE----------------------------------------------------------------------------------YIPWLESQ--------------------------------------------------------------------------------------------------------YRMDARPNGR------FL--Q-G--HS-----------------SG-----------------------------GWASLQLEVDYPRFFGGTWSTSPDPSTFHDFTGIDLYAPHANVYHRPDGTAYPLVRAHGKV-----------------------------------------------------------------------------------------------------------------------------------------LAT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FEQFARLEQVLGPYGGQIASFEWVFSPRGPDGKPEPMFDRSTGDVYPKVVAYWREHYDLAHIV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTTWPQQGRYLKGHIHVYVGTADTFYLNGAARKFDAVLEKLGAEEHFTFRKG-------------------------------------------------------------------------------------------------------------RSHFN----------------------------------------------------------------- 279
280 ---------------------------------------------------------------------PAKNLPVVVNPHG------GPEA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDTWGYDPEV-------------------------------------------------------QLLA----------------------------------------------N-----------------------------R--GMAVLQVNYRVSTGYG-----------KAFWKAGFKQWGQKQQDDITDGVKWLISEGIADPK--------------------------------------------------------R----I-GI--Y-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YATLM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IKT--PELYRCGVDYVGVANLFTLFKSIPSYWRPMLT---VMKET---IGDPKKDKVMFQQYSPVYHADKI--------------------------NVPLFIAQ-----GTNDPRVVKDQS---------------------------------------------------DQMVKAMKARGIEVEYLVKNNEG----------------------------------------------------------HGFSNVENRLDFYRQMSDFLER---------------------------------------------- 280
281 --------QSDKLYGTYYQFDTRTKKFTLLYDLMPQLKEEDMAEMRPIKFKSRDGLTIHGFITLPKAALEGKKVPLIVNPHG------GPQG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IRDSWGFNPET-------------------------------------------------------QLFA----------------------------------------------S-----------------------------R--GYATLQVNFRISGGYG-----------KEFLRAGFKQIGRKAMDDVEDGVRYAISQGWVDPD--------------------------------------------------------R----I-AI--Y-G--AS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YATLM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VKT--PDLYACGVDYVGVSNIYTFFDSFPEYWKPFKE---MVKEIWYDLDNP-EEAAIAKEVSPFFQIDKI--------------------------NKPLFVVQ-----GANDPRVNINES---------------------------------------------------DQIVTALRARGFEVPYMVKYNEG----------------------------------------------------------HGFHREENSMELYRAMLGFFAK---------------------------------------------- 281
282 -------------------------------------------------------------------------HPCFVL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APQCPAD----SSWTELLMRGNPF----KPTKTLLAVANLIRKIISE---E--------------------------------------------------------------N----------------------------------------------I-------------------------------------------------------------------------------------------DSN--------------------------------------------------------R----I-YL--T-G--LS-----------------MG-----------------------------G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGTFALL-----I--------------EH-------------PELFAGAIPICGGA---------------DINNLERIRDIPLW---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----AEDDN--LVSV-----------------------------------------------------------------------------------------------EFSRSVVKRLVEIGGK-VKYTEFLWGEMERMGYHP---HASWIPVYDNEEVIDWL--------------------------------------------------- 282
283 -------------------------------------------------------------------------HPCFVL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APQCPAG----SSWTELLTGGNPF----KPTRNLIAVANLIKKILKE---E--------------------------------------------------------------N----------------------------------------------I-------------------------------------------------------------------------------------------DPD--------------------------------------------------------R----V-YV--T-G--LS-----------------MG-----------------------------G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGTFAIL-----I--------------EY-------------PELFAAAIPICGGG---------------DVNRLERIKDIPLW---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----AEDDN--VVLV-----------------------------------------------------------------------------------------------EFSRAVVRRLVEIGGK-VKYTEFLWGEMERQGYHP---HASWIPVYDNEEVIDWL--------------------------------------------------- 283
284 -------------------------------------------------------------------------YPAFVL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPQCPAG----SYWAYTERPKSLFPADMPAGQEMSSLTRTLKQLLDT---YL----------------------------------------------------------AMPE----------------------------------------------V-------------------------------------------------------------------------------------------DKK--------------------------------------------------------R----I-YI--V-G--LS-----------------MG-----------------------------A-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGTYDLV-----V--------------RY-------------PEIFAAAVPICGSV---------------NPDRLPAAKEVKFR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----GDADD--VVTV-----------------------------------------------------------------------------------------------EGSREAYKALKAAGAK-VEYIEF-----------PGCNHGSWNPAFNYPGFMEWLFK------------------------------------------------- 284
285 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLDYVKKT---Y--------------------------------------------------------------P----------------------------------------------V-------------------------------------------------------------------------------------------DEQ--------------------------------------------------------R----I-YL--T-G--LS-----------------MG-----------------------------G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGTWAWA-----A--------------ER-------------PTEFAAIAPICGGG---------------NPLNAKRLSKLPIW---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----GDKDK--VVPI-----------------------------------------------------------------------------------------------TLSQLMVTALKAEGAK-VDFT-----------IYPNVGH------------------------------------------------------------------- 285
286 ------------------------------------------------------------------------DFPFIVI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPQCPRG----EYW------------------NIERLSTLLDEVIAS---Y--------------------------------------------------------------P----------------------------------------------V-------------------------------------------------------------------------------------------DPD--------------------------------------------------------R----V-YL--T-G--LS-----------------MG-----------------------------G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGTWHLA-----A--------------AQ-------------PERFAAIAPICGGG---------------NPAQAHKLKNLPVW---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----GAKDN--VVPS-----------------------------------------------------------------------------------------------SESEIMVSALKAHDGN-VKFT-----------VYPEADHDSWTQTYNNPELYEWFLQ------------------------------------------------- 286
287 -------------------------------------------------------------------------NPAYVL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APQAEAAGTLTAYWTEEP--------------NYTTMLNLLKETIDK---Y--------------------------------------------------------------D----------------------------------------------I-------------------------------------------------------------------------------------------DKN--------------------------------------------------------R----I-YV--V-G--MS-----------------NG-----------------------------G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IGTWNMI-----K--------------KN-------------PNLFAAAVPICGIGDLPGNKLVRKYEPMQDISAFKDIKDMPIW---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----AEDDP--LVDV-----------------------------------------------------------------------------------------------RYSRDAVQAIKELGGSLVKYTEYPTGI-----VKP-MGHFSWVPALQDKEMINWL--------------------------------------------------- 287
288 FYINENLNTSQNIYRASFDFSIVARLTHIDPLQDFLEEITAIVIESTVPRYDGTLEKVDTTILLPKGIQPNQQLPAIVE------------V-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YP----------------------------------------------GANLQSAVKR----------------------------------------------------F-----------------------------G-------------------------------------------------------------GGNIASFPSRLLLEQGYAIVLPDLRIRPEGESGNPIQETVDRLLPQIYQASCLGLIDINR----L-GL--I-G--QS-----------------FG-----------------------------G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IVTKTNLFRAS-VSISGIYDLTGAYGIFSKNWEGFADTDWYENRQGR------MGTHPWENMFRYLENSP------YYLAKDIYTPLLLIH-----GEKDI--TFEVQEAQKMFTALKRLGKKVNLAVY-----------------------------------------------------------------------------------------------------------KKEGHVINNWNHSNAIDAVKRIIAFYDH-------------------------------------------- 288
289 -------------------------------------------------RYDGTLEKVDTTILLPKGIQPNQQLPAIVE------------V-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YP----------------------------------------------GANLQSAVNR----------------------------------------------------F-----------------------------G-------------------------------------------------------------GGNIASFPSRLLLEQGYAIVLPDLRIRPEGEPGNPIQETVDRLLPQIYQASCLGLIDINR----L-GL--I-G--QS-----------------FG-----------------------------G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IVTKTNLFRAS-VSISGIYDLTGAYGIFSKNWEGFANTDWYENRQVR------MGTHPWENMFRYLENSP------YYLAKDIYTPLLLIH-----GEKDI--TCEVQEAQKMFTALKRLGKKVNLAIY-----------------------------------------------------------------------------------------------------------KKEGH------------------------------------------------------------------- 289
290 EEGVKL---------HTRIFKPRNEGE----------------------------------------EVSDDENLVIVL----V-------H---------------------------------------------------------P--------------------F------------------------------------------------------------------------------------------------------------------------------------------SL-------LG--GCQALLKGIASELA-----SKGFKSVTFDTRGAGKSTGRATLTGFAEV-KD--VVAV----------------------------------------------C-----------------------------R--WLCQ-------------------------------------------------------------------------------------------------------------NVDAHR----I-LL--V-G--SS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PI-AGSAVE-----Q--------------VE-------------Q---VVGYVSLGYPFGLMASILF-------------------------------------------GRHHKAILSSPKPK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LFVM-----GTQDG--FTSVSQLKKKLKSAVGRTETHLIEGV--------------------------------------------------------------------------------------------------------------SHFQME--GPEYDSQVTDIICKFISSL------------------------------------------ 290
291 --------------------------------------VVLTNDENKLFGILHRPLI-SPPYP------------AILI----C-------H---------------------------------------------------------G--------------------F---------------------------------------------------------------------------------------------------------------------------------------------------GGDKLGRNHLYLILAQLLAKEGIATLRIDFRGCGDSEGNFNEVTF----ENLLSD-AKASL----------------------------------------------------------------------------D--FL--------QQDTCIDQNR-------------------------------------------------------------------------------------------------------L-GV--L-G--RS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AL--AVLLASHTNAF--------------KTIC---LW------------------------------------APLFTAEDWKEKWKILQKVKDPHQKEELMRVNGKKASFTFYEQLFQ--------------MCLDKELLNLNQV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHIQ-----GKNDV--IIADSHAQGYRKNRENIQAESKFIEL-----------------------------------------------------------------------------------------------------------PNSDHDFSHT----EEQRLAIEETLTWFKRTL---------------------------------------- 291
292 ----------------------------------------------------------------------------LYL------------H----------------------------------------------------------------------------------------------------------------------------------------------------------------GFNSSPRSA--------------------------------------------------K---ASLLK---------------------------------------------------------------------------------------------------------------------------------------N--WLAE------------------------------------------------------------------------HHPDVEMIIPQLPPY------PSD-------AAELLESIVLEHGGDSLGIV----G--SS-----------------LG-----------------------------G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YYATWLSQCFMLP--------------AVVVNPAVRPFELLTD---YLG-----------QNENPYTGQQYVLESRH--IYDLKVMQ---------IDPLEAPD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WLLQ-----QTGDE--VLDYRQAVAYYASCRQTV-----IEG-------------------------------------------------------------------------------------------------------------GNHA------------------------------------------------------------------ 292
293 -------HNT-----------SICAMICYPNQS---DVLQSLPEQMVYSIMTIRKALFESTSERPSEDAA--SNDRLIIYSHGNA--ETMMH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSAYGFMLADLSGMPVLLYD------------YEGYGASEGKSGE---------------------------------------KTARRDIEAVYR-------------------------------------------------------------------------------YVRET------------------------------------------------------YPE-------------------------------------------------------------YKLI--FMG--RS-----------------IG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-VTTVHIANLYANKKAYQEDRKRDVLAGI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QSGVASALQTLRK------------------------RKINVICDCLRNYDKVGNWSFPCLIIH-----GACDNIVPV------HNAIIMARNVIKHNHPSYLKSFESFIKK----------------------------------------------------------------------------------------------------AHPLDTMDNHCIFRADNFSLLLIAGGDHNSYDIETYELTYSVIAQFLTGDGTIETSIVQGQEMLLQV-- 293
294 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L--M-G--KS-----------------MG-----------------------------S-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVSCMVAS-------SDGINASAVI------------------------CLGY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K--GMKGAMRDEILLK----LRIPTMFVQ-----GNKDCLCP-LDKLELTRKKMTCRNELHVV--DG-------------------------------------------------------------------------------------------------------------GDH------------------------------------------------------------------- 294
295 ------------------------------------------------------------------------AKGVILY----F-------H---------------------------------------------------------G--------------------N----A-----------------------------------------------------------------------------GSL-RT------WGEV-----------------APEL-VQ---Y--------------G---YE-M-----------------VMV----DYRGYG-----------QSTG---TIQSEA--ELHA----------------------------------------------D-----------------------------A--AAVYE-------------------------------------------------------WVR----------------QRYP---------------------------------EEQ----I-VL--Y-G--RS-----------------LG-----------------------------S-GLA-----------------------------------------------------TRLAAVYQPAL---------------------------------------------------------------------------------------------------LILESPFYSVEAIARRQFPWVPPFLLKYP-LRS------------------------------------------------HE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------WIGQV----------------------------------------------------------RC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------VV------------------------------------------------------IIHGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDS--V----------------V--------------PFADGERL---------ARE-VRAPLAFYPI-----------------VGGDHNNL--MTFS----------------------------------MYH------HA-----------------------------------------------IQVALKEL----------- 295
296 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNLPHLMSLASHLASHGFFCLRFTC-----------KGLNIVHRIKAYKSVLNYLRT-SGEYQLAGV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL--G-G--RS-----------------MG-----------------------------S-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RAAASVMCHIEPDDADDFV--RGLI------------------------CISY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHPKQQHKLRDEDLFR----IKEPVLFVS-----GSADEMCE-KNLLEKVAQKMQAPNKIHWI--EK-------------------------------------------------------------------------------------------------------------ANH------------------------------------------------------------------- 296
297 ---------------------------------------------------------------------------IILT------------H---------------------------------------------------------G--------------------A------------------------------------------------------------------------------------------------------------------------------------------SGDMNLPHLMSLASHLASHGFFCLRFTC-----------KGLNIVHRIKAYKSVLNYLKT-SGEYKLAGV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL--G-G--RS-----------------MG-----------------------------S-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RAAASVMCHIEPDDADDFV--RGLI------------------------CISY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHPKQQHKLRDEDLYR----IKDPVLFVS-----GSADEMCE-KNLLEKVAQKMQAPNKIHWI--EK-------------------------------------------------------------------------------------------------------------ANH------------------------------------------------------------------- 297
298 ---------------------------------------------------------------------------IILT------------H---------------------------------------------------------G--------------------A------------------------------------------------------------------------------------------------------------------------------------------SGDMNLPHLMSLASHLASHGFFCLRFTC-----------KGLNIVHRIKAYKSVLNYLKT-SGEYKLAGV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL--G-G--RS-----------------MG-----------------------------S-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RAAASVMCHIEPDDGDDSV--RGLI------------------------CISY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHPKQQHKLRDEDLFR----LKEPVLFVS-----GSADEMCE-KNLLEKVAQKMQAPHKIHWI--EK-------------------------------------------------------------------------------------------------------------ANH------------------------------------------------------------------- 298
299 ---------------------------------------------------------------------------IILT------------H---------------------------------------------------------G--------------------A------------------------------------------------------------------------------------------------------------------------------------------SGDMNLPHLMSLASHLASHGFFCLRFTC-----------KGLNIVHRIKAYKAVLNYLKT-SGEYKLAGV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL--G-G--RS-----------------MG-----------------------------S-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RAAASVMCHTEPDDADDFV--RGLI------------------------CISY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHPKQQHKLRDEDLFR----IKDPVLFVS-----GSADEMCE-KNLLEKVAQKMQAPSKIHWI--EK-------------------------------------------------------------------------------------------------------------ANH------------------------------------------------------------------- 299
300 ---------------------------------------------------------------------------VILT------------H---------------------------------------------------------G--------------------A------------------------------------------------------------------------------------------------------------------------------------------SGDMNLPHLTSLASHLASHGFFCLRFTC-----------KGLNIVHRIKAYKSVLNYLKT-S-EYKLAGV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL--G-G--RS-----------------MG-----------------------------S-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RAAASVLCHIEPDDADDFV--RGLI------------------------CISY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHPKQQHKLRDEDLFR----IKDPVLFVS-----GSADEMCE-KNLLEKVAQKMQAPHKIHWI--EK-------------------------------------------------------------------------------------------------------------ANH------------------------------------------------------------------- 300
301 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNLPHLMSLASHLASHGFFCLRFTC-----------KGLNIVHRIKAYKSVLNYLKT-LGEYKLTGV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL--G-G--RS-----------------MG-----------------------------S-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RAAASVMCHIEPDDADAFV--RGLI------------------------CISY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HHPKQQHKLRDEDLYR----IKDPVLFVS-----GSADEMCE-KNLLEKVAQKMQAPNKIHWI--EK-------------------------------------------------------------------------------------------------------------ANH------------------------------------------------------------------- 301
302 ---------------------------------------------------------------------------VILT------------H---------------------------------------------------------G--------------------A------------------------------------------------------------------------------------------------------------------------------------------GGDMNFPHLVSLAAYLASQGILCLRFTC-----------KGLNIAYRTKAYKTVVEYLKL-SDDYKLSGV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL--A-G--RS-----------------MG-----------------------------S-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RAAASVIRQLSGDN-DDFI--QGLI------------------------CLSY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HRPKLQSKLRDEDLLF----IRCPVLFVS-----GSADEMCE-KQLLESVASKMKAPKKIHWI--DK-------------------------------------------------------------------------------------------------------------ANH------------------------------------------------------------------- 302
303 ---------------------------------------------------------------------------VVLT------------H---------------------------------------------------------G--------------------A------------------------------------------------------------------------------------------------------------------------------------------SGDMNCCHLISLAKYLVSHGFLCLRFTC-----------KSLNIIYRTKAYKAVVEYLRS-SDAYKLSGI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL--G-G--RS-----------------MG-----------------------------S-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RAATSVTRQADQDN-DSFI--QGLI------------------------CLSY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HRPKLQAKCRDEDLLF----IKSPVLFVS-----GTADEMCD-QRLLEDIVVKMKAPMKIHWI--EK-------------------------------------------------------------------------------------------------------------ANH------------------------------------------------------------------- 303
304 ---------------------------------------------------------------------------VILT------------H---------------------------------------------------------G--------------------A------------------------------------------------------------------------------------------------------------------------------------------GGDMNYEHLKVLAKHLAENGIACLRFTC-----------KPTVMRTRVNAMTSVLDFWKQ-STEYPLKKC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL--A-G--RS-----------------MG-----------------------------S-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVAATLAEELTRAK-DQFI--VGVI------------------------CLSY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HPPNKTTEIRH---LQ----PGVPVLFVN-----GKRDALCD-AKLMEKEVQNLQCQYQLHWI--DG-------------------------------------------------------------------------------------------------------------ADH------------------------------------------------------------------- 304
305 ---------------------------------------------------------------------------VILT------------H---------------------------------------------------------G--------------------A------------------------------------------------------------------------------------------------------------------------------------------TGNMNNTQLQTISQYLTTKGFICLRFTY-----------ISSRVENRMKAYHAVVEFLQN-YKEVSLKGC------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FV--A-G--RS-----------------MG-----------------------------S-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RAAVCVANAMK----NDFI--KGVI------------------------CLSY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HPPRKLTSLRNEILQS----LTTPTLFIT-----GTKDAFCT-KTIMEDTLKSITCVKKMKWI--EG-------------------------------------------------------------------------------------------------------------ADH------------------------------------------------------------------- 305
306 -----------------------------------------RPRDAQGIVRGAEPFLLRGTNDR----------A-VLV----L-------H---------------------------------------------------------G--------------------------FNDTP-QSMRHLAMRINDD---------------------------------------------------------GYT-----V----------------------------------------DV------P-R------------LP------------------GHGGS--LAELARDGHAVNW---RRAVRE--AYDA----------------------------------------------L-----------------------------R----------------------------------------------RTHS---V-----------------------------------------------------------------------V-HL--C-G--QS-----------------MG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LAT--------------------------------------------------------------------------------------LEAHDHAE--VRALVLL--------------------------------------APYLGMPFD-------------------------------------------------------------------------------------------------------------------------------------------MRWQTYAAALLAPFTLYHRSKGAERSIHDPAARAKALGPGIVTPGALAGLRTV-------------------------------------------------A--LAA-----------------------------------------------HDALPTLTV--------------------------P-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YL-Q-----SREDN--RIAAA-----------------------------DA-----------------ERYFVRIGSA------------IKKQQWL--TG-------------C------------------------------------GHIISADYCRDTVA-DAAIAWFRR--------------------------------------------- 306
307 ----------------------------------------------------VLLKGWWIPAQKQNKQIDSKKTIIFSH----------------------------------------------------------------------G--------------------Y------------------------------------------------------------------------------------------------------------------------------------------GNN-----------------------------------------------------------------------------------------------------------------------------------------------RELH---------KISVLT---------------------LAKKLCENGYN---VLLFDFRASGESEGKVVTIGGLEK--------------YDLLGAIDFVKNK-------------KQSKEI----NL--I-G--WS-----------------MG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-TSI-LA-----------------------GTESTDVKA---------------------------------------------IVADS---------PFGNLKDYLQDNL---------------------------SYWSKLPNFYFTKAILYLLPKI----RGFSIEDVDTIKAASNMSNKKLF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----SKDDE--AIPYENTEKIYNSVKN-KGCAEIWIT-----------------------------------------------------------------------------------------------------------NNAKH---------IKTYSLYKDQYEKRIIEF---------------------------------------- 307
308 -------------------MNLTSPKKEVLKNTPKDFGLIYEDISFKSKLDGVTLKGWWIPSQSDKNIKSTTKTIIFSH----------------------------------------------------------------------G--------------------Y------------------------------------------------------------------------------------------------------------------------------------------GNN-----------------------------------------------------------------------------------------------------------------------------------------------RGLY---------KISVIN---------------------LAKKLASEGYN---VLTFDFRACGESEGKYVTIGGMEK--------------DDLLGAINFAKSE-------------KHSEKI----NL--I-G--WS-----------------MG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-TSI-LA-----------------------ASDSNDVQA---------------------------------------------VIADS---------PFGNLKDYLEENL---------------------------SYWSHLPNFFFTKTILYTLPKI----RKFDIDKVNAIKAVEKLNNKKIF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----SKDDD--AIPCSNSEKIYNAIQD-KKNAKIWYT-----------------------------------------------------------------------------------------------------------SKAKH---------IKSYSLYKDEYEKKIIDFFK-------------------------------------- 308
309 --------------------------------TPWELEVPYETVEFRSS-DGLRLVGWWLPRP------ETNAVIVGSH----------------------------------------------------------------------G--------------------H------------------------------------------------------------------------------------------------------------------------------------------AGR-----------------------------------------------------------------------------------------------------------------------------------------------KD-------------ELLG---------------------IGSYCWRAGYN---VLLFDYRGRGESDPWPQTLVSREV--------------DDLLAALQYVRQR-------------MPEAAI----GV--I-G--YS-----------------MG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VGI-LA-----------------------TARDQSVRA---------------------------------------------LVADS---------SFTTGDEVVADAV---------------------------EKVLRVP----LRPLVHLADIIVAWRHGYRFSQARPIDAIGQIAPRPVF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----GVDDS--LVPVCHVRQLYAAARE-PRL--VWEI-----------------------------------------------------------------------------------------------------------PGAEH---------CGGYFVDRVGYCRRVVEF---------------------------------------- 309
310 -------------------------------------------------------------MNFPRCKTVKKSLPIFLE----------------------------------------------------------------------G--------------------G--------------------------------------------------------------------------------------------------------------------------------------------NEGVLFIHG-----------------------------------------------YTGSPHDFEYMAKEVNRAGFTVSVPRLPGHGTCGEDFLTTTARDWLRRAFDAYYDLKAI----------------------------------------------------------------------------------------------------------------------------------------------------CDR----VYVV----G--LS-----------------MG--------------------------------GVIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-ILASQMN-----P--------------PK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLAAATHVFD-----------------------KRIVLTPILKLFTKKMPCENTEKYEDPDIEYLRKEYWSY-----------NWPKQAAELYKLMKLARKSVSKITSATLVVAAKNDNMVPMKAAEF-IYNNIRSEKR--KLLVFEKSGHVLSNDVEKEDVTRAVIE----WLKG------------------------------------------ 310
311 -----------------------------------------------------------------------------VY----L-------H---------------------------------------------------------G--------------------F---------------------------------------------------------------------------------GSS-----MLS---------------AKACAIEDALFQRGYSFLRF----T------F-D---DM-QA---------------------------------------DRFFH---LT------VPKM----------------------------------------------V-----------------------------D--QLRRI-VDTLAG-----------------------------------------------AYE--------------------------------------------------------R----IH-L--I-G--SS-----------------LG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-VLARYCE-----Q--------------GA-------------SPAVASLTTLAGSFDFYANRLEGMGADGLQVWKEKGFALFYHYGVNDT---IQLGTAFLEDVESYMPYR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LRTRLP-----------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GKRDE--TVSF--------------------------------------------------------------------------------EQSVAMASEQPLATLKLYEA-------------------------------GDHSL----------------------------------------------------------------- 311
312 -----------------------------------------------------------------------------IY----L-------H---------------------------------------------------------G--------------------F---------------------------------------------------------------------------------ASS-----PNS---------------AKARDIGDRFFKIQ---TKL----K------I-P---DL-NA---------------------------------------GDFSQ---LT------ITR--------------------------------------------------------------------------------QIAQV-AAEFSN-----------------------------------------------DST--------------------------------------------------------P----VT-L--I-G--SS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-TAAHLGQ-----Q--------------YL-------------Q--VERLVLLAPAFGFLSHWLPKLGYEEVQRWQHEKYIMVYHYGEERS---IPLSYDFVIDAAQYQEKF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LQLSIP-----------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GKKDE--VIPI--------------------------------------------------------------------------------EASRDFARCRSWVELVELDS--------------------------------DHAL----------------------------------------------------------------- 312
313 ----------------------QQRVVITNKHGEELVGLLHPVGSNNIV--------------------------VLCH----------------------------------------------------------------------G--------------------F------------------------------------------------------------------------------------------------------------------------------------------TAS-----------------------------------------------------------------------------------------------------------------------------------------------KNSS---------VIADLAD-----------------------ALTKQGTS---IFCFDFSGNGESGGEFQYGNYRKEA-D------------DLHSVVSYLHQ------------------KKYDVKAI--V-G--HS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-VVVLYA-----------------------SMYHD-VNM---------------------------------------------VVNLS---------GRFYLEKGIEERLGKGFIDRINKEGYIEVTKFLVKKKSGKILYRVTKESLMERLNTDMHATS-----------------LSISKECSIF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----GSADE--IVPVEDAYEFAKHIPTHK----LCVI-----------------------------------------------------------------------------------------------------------KGANHCYTAHRKELSNAVVDFI-------------------------------------------------- 313
314 ----------------------QHRVLITNKHGEELVGLLHPAGSNKIV--------------------------VLCH----------------------------------------------------------------------G--------------------F------------------------------------------------------------------------------------------------------------------------------------------TAS-----------------------------------------------------------------------------------------------------------------------------------------------KNDS---------IIVDLAD-----------------------ALTKQGIS---IFRFDFSGNGESGGEFQYGNYRKEA-D------------DLHSVVLYLFQ------------------EKYDVKAI--V-G--HS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-VVVLYA-----------------------SLYDN-VHM---------------------------------------------VVNLS---------GRFYLEQGIEERLGKEFIDRINKEGFIEVT-----DKSGKVLYRVTKESLMERLNTDMRATS-----------------LSIKKECSFL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----GSADE--IIPVEDAYEFAKHIPTHK----LCVI-----------------------------------------------------------------------------------------------------------EGANHCYTAHRKELSDAVVDFI-------------------------------------------------- 314
315 ---------------------TEHRVVITNKHGEELVGLLNPVGSNEIV--------------------------VLCH----------------------------------------------------------------------G--------------------F------------------------------------------------------------------------------------------------------------------------------------------TGS-----------------------------------------------------------------------------------------------------------------------------------------------KNVS---------MIVDLAD-----------------------ALTKQGIG---IFRFDFSGN-ESGGEFQYANYRKEA-D------------DLHSVVLYLHQ------------------EKYDVKAV--V-G--HS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VVVLYA-----------------------SLYHD-VHM---------------------------------------------VLNLS---------GRFYMEKGVEERLGKGFIDRINKEGYIEVT-----DESGKVLYRVTKESLMERLNTDMRAAS-----------------ASISKECSFF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----GSADV--DIPLEDAYEFGKHIPTHE----LRVI-----------------------------------------------------------------------------------------------------------EGADHCYTAHRKELSDAVVDII-------------------------------------------------- 315
316 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KQSK---------TIAGLTD-----------------------ALTSEKIS---VFCFDFSGNGESDGTFQYGNYYKEV-S------------DLHAVIQYFKE------------------HQRYTRAI--A-G--HS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-VVIIYA-----------------------SMYQD-VSS---------------------------------------------IINIS---------GRFDLKRGIGERLGNDYMERISKHGFIDVE-----QKTGHFMYRVTKESLMDRLNTDMQTAC-----------------MSIDPNCRVL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----GSDDD--VVPSEDALEFDKYICNHK----LHVI-----------------------------------------------------------------------------------------------------------EGADHR------------------------------------------------------------------ 316
317 ----------------PSKGIQEQRIVIPNRHNEKLVGLLHETGSTDIV--------------------------VLCH----------------------------------------------------------------------G--------------------F------------------------------------------------------------------------------------------------------------------------------------------RSN-----------------------------------------------------------------------------------------------------------------------------------------------KSNQ---------IMNNVAA-----------------------AIQKEGIS---AFRFDFSGNGESEGSFYYGNYNHEA-D------------DLHSVVQYFSN------------------KNRVVPII--L-G--HS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-VVLLYA-----------------------SKYHD-VRN---------------------------------------------VINLS---------GRYDLKKGIRERLGEDFLERIKQQGFIDVG-----D--GKSGYRVTEKSLMDRLSTDIHEAC-----------------LKIDKECRVL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----GSEDE--VIPVEDAKEFAKIIPNHK----LEIV-----------------------------------------------------------------------------------------------------------EGANHGYTEHQSQLVSTVMEFIKTVI---------------------------------------------- 317
318 ----------------SSQGSTQQKTVILNSHNENLVGLLHETGSTEIV--------------------------VLCH----------------------------------------------------------------------G--------------------F------------------------------------------------------------------------------------------------------------------------------------------RSN-----------------------------------------------------------------------------------------------------------------------------------------------KNFE---------IMKNVAV-----------------------AIEREGIS---AFRFDFSGNGESEGSFYYGNYNYEA-D------------DLHSVIQYFSN------------------LNRVVTII--L-G--HS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-VVLLYA-----------------------SKYHD-IPN---------------------------------------------VINLS---------GRYDLKKGIGERLGEDFLERIKQQGYIDVK-----D--GDSGYRVTEESLMDRLNTDMHEAC-----------------LKIDKECRVL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----GSGDE--TVPVEDAKEFAKIIPNHE----LQIV-----------------------------------------------------------------------------------------------------------EGADHCYTNYQSQLVLTVMEFIKSHC---------------------------------------------- 318
319 ----------------GISATTQQKIVILNSNNEKLVGLLHETGSTEIV--------------------------VLCH----------------------------------------------------------------------G--------------------F------------------------------------------------------------------------------------------------------------------------------------------RST-----------------------------------------------------------------------------------------------------------------------------------------------KNDQ---------VMKNVAA-----------------------AIEKEGIS---AFRFDFSGNGESKGSFYFGNYNYEA-D------------DLHSVIRYFTN------------------MNRVVPII--I-G--HS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-VVLVYA-----------------------SKYQD-IRN---------------------------------------------VINLS---------GRYDLKRGIGERLGEDYLERIKQQGFIDIK-----E--GNAGFRVTEESLMERLNTDMHEAC-----------------LKIDKECRVL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----GSADE--VIPLEDAKEFAKIIPNHK----LEIV-----------------------------------------------------------------------------------------------------------EGADHCYTKHQSQLITNVMEFIKTVI---------------------------------------------- 319
320 --------------------MKPTKIVIPNRRNEKLVGLLHETGSKEVV--------------------------VLCH----------------------------------------------------------------------G--------------------F------------------------------------------------------------------------------------------------------------------------------------------RSD-----------------------------------------------------------------------------------------------------------------------------------------------KTNK---------ILKNVAT-----------------------ALEKEKIS---SFRFDFSGNGDSEGTFYYGNFNSEAED------------DLHYVIQHLSSS---------------NIMNRLVPVI--L-G--HS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-VVLLYA-----------------------SKFPDYIRN---------------------------------------------VVNIS---------GRFDLKNDV--RLGDGYIEKIKEQGFIDAT-----E--GKSCFRVTQESLMDRLNTDMHQAC-----------------LNIDKQCKVL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----GSDDT--VVPGEDAKEFAKVIPNHK----LEIV-----------------------------------------------------------------------------------------------------------EGANHGYTKHQKELVSIAVEFTKTAI---------------------------------------------- 320
321 -------------------------------------------GSTETV--------------------------VICH----------------------------------------------------------------------G--------------------F------------------------------------------------------------------------------------------------------------------------------------------RSS-----------------------------------------------------------------------------------------------------------------------------------------------KNRI---------PMLTIAS-----------------------FFERAMIS---SFRFDFAGNGESQGSFQYGNYRREV-E------------DLRSVLQHLRG------------------VNRVISAI--I-G--HS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-VVLLYA-----------------------AKYND-VQT---------------------------------------------VVNIS---------GRFFLDRGIEFRLGKDYFKRIKDNGFIDVS-----NRKGKFEYRVTEESLMDRLTTNAHEAC-----------------LSIRENCRVL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----GSNDR--IVHVTEASEFAKQIKNHK----LYVI-----------------------------------------------------------------------------------------------------------EGADH------------------------------------------------------------------- 321
322 ----------------LCAEIQHQRVVIENSHGEKLVGVLHDTGSTETV--------------------------VICH----------------------------------------------------------------------G--------------------F------------------------------------------------------------------------------------------------------------------------------------------RSS-----------------------------------------------------------------------------------------------------------------------------------------------KNRI---------PMLTIAS-----------------------FFERAMIS---SFRFDFAGNGESQGSFQYGNYRREV-E------------DLRSVLQHLRG------------------VNRVISAI--I-G--HS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-VVLLYA-----------------------AKYND-VQT---------------------------------------------VVNIS---------GRFFLDRGIEFRLGKDYFKRIKDNGFIDVS-----NRKGKFEYRVTEESLMDRLTTNAHEAC-----------------LSIRENCRVL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----GSNDR--IVHVTEASEFAKQIKNHK----LYVI-----------------------------------------------------------------------------------------------------------EGADHEFTSHQHQLASIVLSFFKLDP---------------------------------------------- 322
323 -----------------------QRVLISNKHSEELVGLLHEACSKELV--------------------------ILCH----------------------------------------------------------------------G--------------------F------------------------------------------------------------------------------------------------------------------------------------------RAT-----------------------------------------------------------------------------------------------------------------------------------------------KESL---------ILVDLAA-----------------------AIAKEEIN---SFRFDFAGNGESEGEFQCGNYQKEA-E------------DLRSVVSYLSE------------------QKYDIIAL--V-G--HS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-AVLLYA-----------------------SMYPD-VPA---------------------------------------------IVNIS---------GRFALEHGMEGRLGKNFIQRIRKDGYIDVR-----NRKGEFEYRVTEESLRDRLSTDTLLSS-----------------RSISKNCRVL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----GSKDE--TVPARDALMFAANIPNHE----LHIV-----------------------------------------------------------------------------------------------------------AGANHWYTGHEQELTSLVLDFIRPRP---------------------------------------------- 323
324 ------------------------------------------------------------------VKILHKTGGFTIA----G-------T---------------------------------------------------------L--------------------T----A-----------------------------------------------------------------------------PKD-AN------KTKGTVILI--SGSGLQDRDETIFG-HK---PFAVLAD------Q-L---TR-HG-------------YAVLRCDDRGFGESAGDASQATTDTLAGDIE---SELAYL--RQHY----------------------------------------------P-----------------------------R--L-------------------------------------------------------------------------------------------------------------------TDK----V-FL--I-G--HS-----------------EG-----------------------------G-IIAPM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-ARR------------------------------------------------VG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GIAGLVLVGAPSVKGAEILLSQNAAMDEFATGQPQSQAKRAALEELIRQATAPGDTSDIRTRIESYCRSNASVLFPQAMTDEMKEQGIKLMTEQLSNPWMRHFLTYDPAPLLDVTSGEGSHPL--P--------------------------------------------------------------------------------------------------------------------------------P-------------------------------TM------------------------------------------------------AIYGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDK--Q----------------V--------------LHEVNMSK-------------MKS--------------------------LLGIETGNTANKV------------------------------V--YLP--E-VNHI---------MQP-AE--------------------------------------------------- 324
325 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VVKYA---LHRLHFPPAH-------------------------------------------------------------------------------V-VV--Y-G--WS-----------------IG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FTATWATMT-----Y--------------PE-------------LGALVLDATFD-DLVPLALKVMPRSWKGLVVRTVREHFNLNVAEQLCCYPGP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLRR-----TLDDV--VSTSGHVRPLPS----GDVEGNRGNELLLRLLQHRYPVVMAREGLAAVTRWLRAGSLAQEATFYARYRVDDE---WCRALLRSYRARREDEQEDEQKDWGPHGLAFPWLVGQDLSPRRRRQLALFLARRHLKNVEATHFS----------------------------------------------------------------- 325
326 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WN--HPGFGGSTGAPFPPHDANAVDVVVKYA---LHXLHFPPAH-------------------------------------------------------------------------------V-VV--Y-G--WS-----------------IG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FTATWATMT-----Y--------------PE-------------LGALVLDATFD-DLVPLALKVMPQSWKGLVVRTVREHFNLNVAEQLCRYPGP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLRR-----TQDDV--VSTSGHLRPLPS----GDVEGNRGNELLLRLLQHRYPSVMVREGLAVVTRWLRVGSLAQEAAFYARYRVDDE---WCLALLRSYRARCEDEQEDEEA-WGPHGLAFPWLVGQGLSPRRRRQLALFLARKHLKNVEATHCS----------------------------------------------------------------- 326
327 ----------------------------------------------------------------------------DTMFMDRR--QHPGSHGRGLCLVICCEGNAGFYEMGCLSAP------------------------------LEA--------------------G------------------------------------------------------------------------------------------------------------------------------------------------YSVLG------------------------------------------------------------------------------------------------------------------------------------------WN--HPGFGGSTGAPFPQHDANAMDVVVKYA---LHRLNFPPAH-------------------------------------------------------------------------------V-VV--Y-G--WS-----------------IG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FTATWATMT-----Y--------------PE-------------LGALVLDATFD-DLVPLALKVMPQSWKGLVVRTVREHFNLNVAEQLCCYPGP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLRR-----TQDDV--VSTSNHIPSMPSCQVEGDVEGNRGNELLLRLLQHRYPSVMAREGRTVVTRWLRASNLAQETALYARYRVDDE---WCLATLRSYRERCQKELDDAEA-WGPHGLSFPWFVGQGLSARRRRQLALFLARRHLKNLEATHCS----------------------------------------------------------------- 327
328 ----------------------------------------------------------------------------DTMFMDRR--QHPGSHVHGPRLVICCEGNAGFYEMGCLSAP------------------------------LEA--------------------G------------------------------------------------------------------------------------------------------------------------------------------------YSVLG------------------------------------------------------------------------------------------------------------------------------------------WN--HPGFGSSTGVPFPQHDANAMDVVVEYA---LHRLHFPPAH-------------------------------------------------------------------------------L-VV--Y-G--WS-----------------VG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FTATWATMT-----Y--------------PE-------------LGALVLDATFD-DLVPLALKVMPHSWKGLVVRTVREHFNLNVAEQLCCYPGP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLRR-----TQDDV--VSTSGRLRPLSP----GDVEGNRGNELLLRLLEHRYPVVMAREGRAVVTRWLRAGSLAQEAAFYARYRVDED---WCLALLRSYRARCEEELEGEEA-LGPHGPAFPWLVGQGLSSRRRRRLALFLARKHLKNVEATHFS----------------------------------------------------------------- 328
329 ---------------------------------------------------------------------EGSKKFVVFP------------H---------------------------------------------------------G--------------------G------------------------------------------------------------------------------------------------------------------------------------------PHGMSSTEFNRQALIFALAGWATARPNYVGSTGYPIKQIKKIFGNAGTKDLNDVVETVRMCKKKFGAEKV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GV--W-G--WS-----------------HG-----------------------------G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLSAHMACKFSKEI-NFAVIGAPVINLVSSFFTCDIPDWSLVEAGLSDECDGE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTPKVMTKLWEMSPLKFVDGVTVPVLLGH-----GNLDRRVPFQQSVEFYQALKRAGKKVTFLQYDG-------------------------------------------------------------------------------------------------------------NGHGMRQKDAFDD--------------------------------------------------------- 329
330 LKCPVFREYQAPEVYGLKGARNVYLPSTNGVQLGVWQMLPNS-----ARTANDEEGEITAEFFDKAL-GDNR--PVIMY----C-------H---------------------------------------------------------G--------------------N----S-----------------------------------------------------------------------------GSR-AN------PHRVELYKL--L----------------------------------T----R-IG-------------FHVVAV----DYRGYG------DSSS-HTTP---DGIHDD--VQTV----------------------------------------------Y-----------------------------T--WLRKR-------------------------------------------------------TG------------------------------------------------------DSP----F-YI--W-G--HS-----------------LG-----------------------------T-GISTV---FTSKICREDGC-----PT-GLILEAPFNNLLDEVMRHPFGWA-WNILPYSRGYFDQAFNSTAQ---------------------------------------------------------------------------------------------------------------------------Y-FQS------------------------------------------------DI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIEHV----------------------------------------------------------TC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------IL------------------------------------------------------ILHAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDW--V----------------V--------------PHDLGKKL---------YDI-ALEKRP---------------------ASAGPIKM--ISFG----------------------------------SEE--G-CGHK---------NIA-FSTKLPSVL-------------------------------------------- 330
331 ---------------------------------GIWQILPKS--------LLESSQEKTSEYYEKAL-SDGK--HVILY----F-------H---------------------------------------------------------G--------------------N----S-----------------------------------------------------------------------------GNR-AF------AHRIELYNL--F----------------------------------S----W-QD-------------YHTIAF----DYRGYG------DSNG-TSNA---VGILQD--AEVM----------------------------------------------Y-----------------------------K--WLKPR-------------------------------------------------------IG------------------------------------------------------KAK----L-YL--Y-G--HS-----------------LG-----------------------------T-AVATA---LSRELCD-AGE-----CPSGLILESPFTDLIDEARNHPLSRF-WKFWPGFDQMFLNAFLESAI---------------------------------------------------------------------------------------------------------------------------P-FNS------------------------------------------------TE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIDYV----------------------------------------------------------KC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-------------------------------IL------------------------------------------------------IMHAK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDL--V----------------V--------------PFILGEKL---------AQH-AGKNRP---------------------AGAGALKF--LAFR----------------------------------ADK--G-YGHK---------HLV-RATELPKIISDFI---------------------------------------- 331
332 ---------------------------------GAWHLLPKS--LIRNETL-------D---FESKL-SSGH--PIFLY----L-------H---------------------------------------------------------G--------------------S----T-----------------------------------------------------------------------------GTR-GG------WHRVQLMKL--L----------------------------------T----S-LD-------------FHVVTI----DYRGYA------DSTG-HPSE---DGVVDD--SHFM----------------------------------------------Y-----------------------------R--WIKER-------------------------------------------------------SG------------------------------------------------------ASQ----V-VL--W-G--HS-----------------LG-----------------------------A-AITTK---LAKRLCEEGV------DPHGVILESPFNNIRDAALSHPFAAP-FQHIPFYKKLILDSVAQNNV---------------------------------------------------------------------------------------------------------------------------F-FTS------------------------------------------------DE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NIAAV----------------------------------------------------------KS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------VI------------------------------------------------------IMHAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDL--V----------------I--------------PYDLGLKL---------YKS-AQQNRP---------------------EGSGPLQF--VPLK----------------------------------ASF--G-YGHK---------HIF-QAPELPEIIK------------------------------------------- 332
333 -------------TSNGGSIVGDEKHHAGDRYKGIEK-------VLRSDGFQLTDEKHQRDLFEETLRATTN--DVVLY----L-------H---------------------------------------------------------G--------------------N----T-----------------------------------------------------------------------------ASR-GA------PHRVELYQM--L----------------------------------R----A-LN-------------YHVIAI----DYRGYG------DSANLSPSE---LGVVYD--ALAV----------------------------------------------Y-----------------------------Q--YITSI-------------------------------------------------------T-------------------------------------------------------NNP----V-YL--W-G--HS-----------------LG-----------------------------T-GVSTH---LLSLLTEMSLP-----GPKAVVLESPFNNIKEEICAHPFSKL-YRHLPWFDYLISRPMYKNKL---------------------------------------------------------------------------------------------------------------------------R-FES------------------------------------------------DQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------HIAEF----------------------------------------------------------RQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------VL------------------------------------------------------ILHAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDL--V----------------V--------------PFELGYKL---------YRK-ALDTRG---------------------KSWGPIEF--HRFE----------------------------------KSS--H-YGHK---------YIC-RAPNLPEIIVRFFHAYRDAQY-------------------------------- 333
334 --------------------VAQDPDQQLDPAPGNERELKELSPAIRSE-FPVVLPENEQLFYERLLRMPGG--TVVLY----L-------H---------------------------------------------------------G--------------------N----T-----------------------------------------------------------------------------ASR-GS------GHRSEVYKL--L----------------------------------R----K-LN-------------YHVFSF----DYRGYA------DSDPVPPTE---EGVVRD--AMMV----------------------------------------------F-----------------------------E--YIANT-------------------------------------------------------T-------------------------------------------------------SNP----I-VV--W-G--HS-----------------LG-----------------------------T-GVATH---LCAKLASLRER-----APRGVILESPFTNIRDEIRMHPFAKL-YKNLPWFNFTISQPMYTNRL---------------------------------------------------------------------------------------------------------------------------R-FES------------------------------------------------DV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVLEF----------------------------------------------------------RQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------IM------------------------------------------------------IIHAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDV--V----------------V--------------PFNLGYRL---------YRI-ALDGRS---------------------RTSGPVEF--HRFG----------------------------------ASR--K-YGHK---------YLC-RAPELPGLIQKFVENYRDAVY-------------------------------- 334
335 ----------------------------------------------------------------------------ILY----L-------H---------------------------------------------------------G--------------------N----M-----------------------------------------------------------------------------GSR-AM------HHRVQFYKR--L----------------------------------S----K-MG-------------YHILAI----DYRGFG------DSEG-SPSE---EGLVED--SKIA----------------------------------------------Y-----------------------------K--WLNNR-------------------------------------------------------AR------------------------------------------------------GFA----I-YV--W-G--HS-----------------LG-----------------------------S-AVAVQ---LSSWLNAERA------QLNGVVLEAPFNNITDAIIQTPLALPLYQFLPNFESYLDDV----KN---------------------------------------------------------------------------------------------------------------------------V-FLS------------------------------------------------TF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------WIQKV----------------------------------------------------------TS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------TL------------------------------------------------------ILHDV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDS--I----------------I--------------NINLARKL---------YAV-A---KA---------------------NGSTNVRM--IEFD----------------------------------EQL-----DHC---------EVS-SAKQFKKLFSDFV---------------------------------------- 335
336 ---------------------------------GAWHTLP-S--KVKAPTL-------DTNFFAQSL-SNGS--PIVLY----L-------H---------------------------------------------------------G--------------------N----A-----------------------------------------------------------------------------GTR-AG------WHRMQMYQI--L----------------------------------S----G-AG-------------FHVIAI----DYRGFG------DSAG-YPSE---QGVCAD--AMAA----------------------------------------------F-----------------------------K--WIRKH-------------------------------------------------------SK------------------------------------------------------KSP----V-YI--W-G--HS-----------------LG-----------------------------S-AVATK---VARKISSQGL------SLSGVILEAPFNNIKSAVWEYPLAKP-FVMMPWFSWVFLEALKANEI---------------------------------------------------------------------------------------------------------------------------Y-FTT------------------------------------------------DE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------HIAAV----------------------------------------------------------TA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------VL------------------------------------------------------ILHAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDG--I----------------V--------------PIFLGRKL---------YET-ALANKA---------------------IGG--VRF--HTFS----------------------------------AEH--A-YGHK---------HMH-KAPELASIISDF----------------------------------------- 336
337 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M----------------------------------S----D-NG-------------FHVLAV----DYRGYA------DSTG-HPSE---NGFTKD--ILCI----------------------------------------------Y-----------------------------D--WVKAR-------------------------------------------------------SG------------------------------------------------------NST----V-IF--W-G--HS-----------------LG-----------------------------T-GIATN---TAKKLQEIDGV-----VVDAIVLEAPYTNIRDAAANIPFTRI-YRMFPGFEYFVLDTMARADM---------------------------------------------------------------------------------------------------------------------------Y-FQN------------------------------------------------DK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVKIL----------------------------------------------------------SS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------LL------------------------------------------------------ILHSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDK--V----------------I--------------PVQLGKKL---------FEI-AHNASE---------------------KKD-NVQF--ISFP----------------------------------AAM--G-LGHD---------HIA-ANPELASILKNFL---------------------------------------- 337
338 ---------------------------------GIWHTVPGS--------SGNEARGREQRWFEEAL-ADAH--PIIIY----L-------H---------------------------------------------------------G--------------------N----G-----------------------------------------------------------------------------GTR-AA------RHRIQFMKL--M----------------------------------G----A-AG-------------FHILAL----DYRGYG------DSSG-QPSE---SGFTTD--VLAL----------------------------------------------Y-----------------------------D--WAKAR-------------------------------------------------------SG------------------------------------------------------NSS----I-IF--W-G--HS-----------------LG-----------------------------T-GIATN---AARKLQEERGV-----QVDAVVLESPYTNIRDAAANIPITKI-YRQFPGFEYLILDSMALGNM---------------------------------------------------------------------------------------------------------------------------F-FRN------------------------------------------------DE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVKVL----------------------------------------------------------AC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------LL------------------------------------------------------ILHAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDT--V----------------L--------------PPRLGRQL---------FET-ARRAYK---------------------DKS-KVKF--ITFP----------------------------------GKL--G-LGHD---------YIS-SNPELPTLVKDFLN--------------------------------------- 338
339 ---------------------------------GIWHTVPSC--------RGEDAKGKDRCWYEAAL-HDGN--PIIVY----L-------H---------------------------------------------------------G--------------------S----A-----------------------------------------------------------------------------EHR-AA------PHRLKLVKV--L----------------------------------S----D-GG-------------FHVLSV----DYRGFG------DSTG-KPTE---EGLTAD--AICV----------------------------------------------Y-----------------------------E--WTKAR-------------------------------------------------------CG------------------------------------------------------TTP----V-CL--W-G--HS-----------------LG-----------------------------T-GVATN---AAKVLEE-KGF-----PVDAIILEAPFTNIWVASINYPLLKI-YRKLPGFLRTLMDALRKDKI---------------------------------------------------------------------------------------------------------------------------V-FPN------------------------------------------------DE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVRSL----------------------------------------------------------SS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------LL------------------------------------------------------IIHGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDN--T----------------V--------------PLEFGKKL---------YEI-AHNAYR---------------------NKE-RVKM--VIFP----------------------------------P----G-FQHN---------LLC-KSPMLLKTVRDFLSKQW------------------------------------ 339
340 ---------------------------------GIWHTVPSC--------RGKDAKGKDCGWYEAAL-HDGN--PIIVY----L-------H---------------------------------------------------------G--------------------S----A-----------------------------------------------------------------------------EHR-AA------PHRLELVKV--L----------------------------------S----D-GG-------------FHVLSV----DYRGFG------DSTG-KPTE---EGLTSD--AVCV----------------------------------------------Y-----------------------------E--WTKAR-------------------------------------------------------SG------------------------------------------------------TTP----V-CL--W-G--HS-----------------LG-----------------------------T-GVATN---AAKVLEE-KGF-----PVDAIILEAPFTNIWVASINYPLLKI-YRKLPGFLRTLMDALRKDKI---------------------------------------------------------------------------------------------------------------------------V-FPN------------------------------------------------DE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVKCL----------------------------------------------------------SS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------LL------------------------------------------------------IIHGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDN--T----------------V--------------PLEFGKEL---------YEI-AHNAYR---------------------NKE-RVKM--VIFP----------------------------------S----G-FQHN---------FLC-RNPTLLKTVRDFLSKQW------------------------------------ 340
341 ---------------------------------GIWHTVPSC--------RGEDAKGKDCCWYEAAL-RDGN--PIIVY----L-------H---------------------------------------------------------G--------------------S----A-----------------------------------------------------------------------------EHR-AA------SHRLKLVKV--L----------------------------------S----D-GG-------------FHVLSV----DYRGFG------DSTG-KPTE---EGLTTD--AICV----------------------------------------------Y-----------------------------E--WTKAR-------------------------------------------------------SG------------------------------------------------------ITP----V-CL--W-G--HS-----------------LG-----------------------------T-GVATN---AAKVLEE-KGC-----PVDAIVLEAPFTNMWVASINYPLLKI-YRNIPGFLRTLMDALRKDKI---------------------------------------------------------------------------------------------------------------------------I-FPN------------------------------------------------DE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVKFL----------------------------------------------------------SS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------LL------------------------------------------------------ILHGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDR--T----------------V--------------PLEYGKKL---------YEI-ARNAYR---------------------NKE-RVKM--VIFP----------------------------------P----G-FQHN---------LLC-KSPTLLITVRDFLSKQW------------------------------------ 341
342 ------------------------------------HTVPSC--------RGEDAKGKDRSWYEAAL-RDGN--PIIVY----L-------H---------------------------------------------------------G--------------------S----A-----------------------------------------------------------------------------ENR-AA------PHRIKLVKV--L----------------------------------S----D-GG-------------FHVLSV----DYRGFG------DSTG-KPTE---EGLTAD--ALFV----------------------------------------------Y-----------------------------E--WTKAR-------------------------------------------------------SG------------------------------------------------------TTP----V-CL--W-G--HS-----------------LG-----------------------------T-GVATN---AARVLEE-RGS-----PADAIILEAPFTNIWVASINYPLLKI-YRKLPGFLRTLMDALRKDKI---------------------------------------------------------------------------------------------------------------------------V-FPN------------------------------------------------DE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVKFL----------------------------------------------------------SS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------LL------------------------------------------------------ILHGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDR--T----------------V--------------PLEIGKQL---------YEI-AHSAYR---------------------KKE-RVKM--VVFP----------------------------------P----G-FHHN---------LLC-ESPTLLKTVRDFLSEQW------------------------------------ 342
343 ---------------------------------GIWHTVPSY--------RGEEAKGKCRCWYEASL-SDGN--PIIIY----L-------H---------------------------------------------------------G--------------------S----G-----------------------------------------------------------------------------INR-AF------CGRIKLTQV--L----------------------------------S----D-GG-------------FHVLSV----DYRGFG------DSTG-TTTE---EGLTTD--IICV----------------------------------------------Y-----------------------------E--WTKAR-------------------------------------------------------SG------------------------------------------------------RTP----V-CL--W-G--HS-----------------LG-----------------------------T-GVATN---AARVLEA-KGC-----PVDAIILEAPFTNIWAATINFPLVKM-YWKLPGCLRTFVDALKEEKI---------------------------------------------------------------------------------------------------------------------------V-FPN------------------------------------------------DE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVKFL----------------------------------------------------------SS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------LL------------------------------------------------------ILHGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDR--T----------------V--------------PLEFGKQL---------YEI-ARSAYR---------------------NKE-RVKM--VVFP----------------------------------P----G-FHHD---------YLF-KSPMLLSTVRDFLSEQW------------------------------------ 343
344 ---------------------------------GVWHTVPAV--------WWKDAQGKDQMWYEDAL-ATSH--PIILY----L-------H---------------------------------------------------------G--------------------N----A-----------------------------------------------------------------------------GTR-GG------DHRVELYKV--L----------------------------------S----S-LG-------------YHVVTF----DYRGWG------DSVG-TPSE---RGMTYD--ALHV----------------------------------------------F-----------------------------D--WIKAR-------------------------------------------------------SG------------------------------------------------------DNP----V-YI--W-G--HS-----------------LG-----------------------------T-GVATN---LVRRLCE-RET-----PPDALILESPFTNIREEAKSHPFSVI-YRYFPGFDWFFLDPITSSGI---------------------------------------------------------------------------------------------------------------------------K-FAN------------------------------------------------DE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVKHI----------------------------------------------------------SC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-------------------------------LL------------------------------------------------------ILHAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDP--V----------------V--------------PFQLGRKL---------YNI-AAPSRS---------------------FRDFKVQF--IPFH----------------------------------SDL--G-YRHK---------YIY-KSPELPRILR------------------------------------------- 344
345 ---------------------------------GVWHTVPAV--------WWKDAQGKDQMWYEDAL-ASSH--PIILY----L-------H---------------------------------------------------------G--------------------N----A-----------------------------------------------------------------------------GTR-GG------DHRVELYKV--L----------------------------------S----S-LG-------------YHVVTF----DYRGWG------DSVG-TPSE---RGMTYD--ALHV----------------------------------------------F-----------------------------D--WIKAR-------------------------------------------------------SG------------------------------------------------------DNP----V-YI--W-G--HS-----------------LG-----------------------------T-GVATN---LVRRLCE-RET-----PPDALILESPFTNIREEAKSHPFSVI-YRYFPGFDWFFLDPITSSGI---------------------------------------------------------------------------------------------------------------------------K-FAN------------------------------------------------DE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVKHI----------------------------------------------------------SC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-------------------------------LL------------------------------------------------------ILHAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDP--V----------------V--------------PFQLGRKL---------YNI-AAPSRS---------------------FRDFKVQF--IPFH----------------------------------SDL--G-YRHK---------YIY-RSPELPRILR------------------------------------------- 345
346 ---------------------------------GVWHTVPAV--------WWKNAQGKDQMWYEDAL-ASSH--PIILY----L-------H---------------------------------------------------------G--------------------N----A-----------------------------------------------------------------------------GTR-GG------DHRVELYKV--L----------------------------------S----S-LG-------------YHVVTF----DYRGWG------DSVG-TPSE---RGMTYD--ALHV----------------------------------------------F-----------------------------D--WIKAR-------------------------------------------------------SG------------------------------------------------------DNP----V-YI--W-G--HS-----------------LG-----------------------------T-GVATN---LVRRLCE-RET-----PPDALILESPFTNIREEAKSHPFSVI-YRYFPGFDWFFLDPITSSGI---------------------------------------------------------------------------------------------------------------------------K-FAN------------------------------------------------DE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVKHI----------------------------------------------------------SC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------LL------------------------------------------------------ILHAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDP--V----------------V--------------PFQLGRKL---------YSI-AAPARS---------------------FRDFKVQF--VPFH----------------------------------SDL--G-YRHK---------YIY-KSPELPRILR------------------------------------------- 346
347 ---------------------------------GVWHTVPTV--------WWKNAQGKDQMWYEDAL-ASSH--PIILY----L-------H---------------------------------------------------------G--------------------N----A-----------------------------------------------------------------------------GTR-GG------DHRVELYKV--L----------------------------------S----S-LG-------------YHVVTF----DYRGWG------DSVG-TPSE---RGMTYD--ALHV----------------------------------------------F-----------------------------D--WIKAR-------------------------------------------------------SG------------------------------------------------------DNP----V-YI--W-G--HS-----------------LG-----------------------------T-GVATN---LVRRLCE-RET-----PPDALILESPFTNIREEAKSHPFSAI-YRYFPGFDWFFLDPITSSGI---------------------------------------------------------------------------------------------------------------------------K-FAN------------------------------------------------DE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVKHI----------------------------------------------------------SC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-------------------------------LL------------------------------------------------------ILHAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDP--V----------------V--------------PFQLGRKL---------YNI-AAPSRS---------------------FRDFKVQF--IPFH----------------------------------SDL--G-YRHK---------YIY-KSPELPRILREFLGRAE------------------------------------ 347
348 ---------------------------------GVWHTIPSV--------WWKNAQGKDQMWYEDAL-ASNH--AIILY----L-------H---------------------------------------------------------G--------------------N----A-----------------------------------------------------------------------------GTR-GG------DHRVELYKV--L----------------------------------S----S-LG-------------YHVVTF----DYRGWG------DSVG-TPSE---RGMTYD--ALHV----------------------------------------------F-----------------------------D--WIKAR-------------------------------------------------------SG------------------------------------------------------DNP----V-YI--W-G--HS-----------------LG-----------------------------T-GVATN---LVRRLCE-RET-----PPDALILESPFTNIREEAKSHPFSVI-YRYFPGFDWFFLDPITSSGI---------------------------------------------------------------------------------------------------------------------------K-FAN------------------------------------------------DE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NMKHI----------------------------------------------------------SC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------LL------------------------------------------------------ILHAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDP--V----------------V--------------PFHLGRKL---------YNI-AAPSRS---------------------FRDFKVQF--IPFH----------------------------------SDL--G-YRHK---------YIY-KSPELPRILREFLGKSE------------------------------------ 348
349 ---------------------------------GVWHTVPAV--------LWKDAQSKDQPWYEDIL-GSNH--PVILY----L-------H---------------------------------------------------------G--------------------N----A-----------------------------------------------------------------------------GTR-GG------DHRVELYKV--L----------------------------------S----S-LG-------------FHVVTF----DYRGWG------DSIG-TPSE---SGMTYD--ALHV----------------------------------------------F-----------------------------D--WIKAR-------------------------------------------------------SG------------------------------------------------------DNP----V-YI--W-G--HS-----------------LG-----------------------------T-GVATN---LVRRLCE-RET-----PPDALILESPFTNIREEAKSHPFSVI-YRYFPGFDWFFLDPITSSGI---------------------------------------------------------------------------------------------------------------------------K-FAN------------------------------------------------DE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVKHI----------------------------------------------------------SC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-------------------------------LL------------------------------------------------------ILHAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDP--V----------------V--------------PFHLGKKL---------YNI-AAPSRS---------------------FRDFKVQF--VPFH----------------------------------TDL--G-YRHK---------YIY-KSPELPRILR------------------------------------------- 349
350 ---------------------------------GVWHTVPAA--------LWKNARGKDQLWFEDAL-GSSH--PVILY----L-------H---------------------------------------------------------G--------------------N----A-----------------------------------------------------------------------------GTR-GG------DHRVELYKV--L----------------------------------S----S-LG-------------YHVVTF----DYRGWG------DSVG-SPSE---RGMTYD--ALHV----------------------------------------------F-----------------------------D--WIKAR-------------------------------------------------------SG------------------------------------------------------DNP----V-YI--W-G--HS-----------------LG-----------------------------T-GVATN---LVRRLCE-RET-----PPEALILESPFTNIREEARSHPFSVI-YRYFPGFDWFFLDPITTSGI---------------------------------------------------------------------------------------------------------------------------K-FAN------------------------------------------------DE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NVKYI----------------------------------------------------------SC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-------------------------------LL------------------------------------------------------ILHAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDP--V----------------V--------------PFHLGKKL---------YNI-AATSRS---------------------FRDYKVQF--VPFH----------------------------------TDL--G-YRHK---------YIY-RSPELPRILR------------------------------------------- 350
351 ---------------------------------GVWHILPSN---------NEEISATDSRSYEEIMNSLPNDIPVFIY----F-------H---------------------------------------------------------G--------------------N----S-----------------------------------------------------------------------------KSR-AI------PWRVNIYKL--L----------------------------------S----S-LG-------------YHVFCF----DYRGYG------DSTGSLTGE---NDCLLD--SLTV----------------------------------------------V-----------------------------Q--FVCKR-------------------------------------------------------FP------------------------------------------------------SAP----I-FF--W-G--HS-----------------LG-----------------------------T-GVVGC---LMDHFNKEHDSLANIRLPKGIILDAPFTCLTDVIHHRIFMKP-YRLMPILQGRLVSAMNKVKL---------------------------------------------------------------------------------------------------------------------------S-FNT------------------------------------------------QS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLINC----------------------------------------------------------PI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------II------------------------------------------------------ILHAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDA--V----------------V--------------PFTLGKKL---------AEI-LSTNGT-------------------------SVFF--KPYE----------------------------------GKL--G-YRHN---------FIH-TAPDLPDII-------------------------------------------- 351
352 ----------------------------------------------------------------------------ALE----------------------------------------------------------------------G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YQSAVAQLNAAGMI-----DPG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R----VGVV----G--FS-----------------LT-----------------------------CWYAAYA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-V-----H-----D--------------PT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HAATIADGLD-----------------------NSYMQ---FMMFT-------------PGEYFLRRQMLGVRGVAPFGVGLAHWVKTSAAFH---------FDRIQAPVRIEAIGPSSVL----QEWDLYASLRLLKKPVDLIYFPHGTHIHKHPLARLESQQGNVDWMYFWLKGEELPDQSSVVSYPEWESMRRS--------------------- 352
353 --------------------------------HSKKIFEIPLLDNVTSLGVLHIPHSQEKTFPLVI----------VL-------------H---------------------------------------------------------G--------------------L---------------------------------------------------------------------------------------------------------------------------------------------------ASSKIGTKRSYLHLANQLVQEGIGVLRVDLPGHGDSEG--------FIHEFSLTDYIQASQ----------------------------------------------------------------------------K--IIQFGFSLPQANH------S-------------------------------------------------------------------------------------------------------V-AL--F-G--SS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SL--SLLNLPYFPEI--------------QHAA---IW------------------------------------TPTIQGALWLED-----------TMQS-MSPSLQLPPDNFSYQGIPLGKKFCSQFIELDTVDALSKI--TQEV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LYLQ-----GEDDA--VVSLRH---QALFAKTFTGKASYRIY-----------------------------------------------------------------------------------------------------------PKMTHQLCIY----S--E-AFQDLVDWLKHQLL--------------------------------------- 353
354 ---------------------------------GVWY-VPRV----------------STTEAPNSL-ADGY--PVVLY----L-------H---------------------------------------------------------G--------------------N----T-----------------------------------------------------------------------------GTR-GT------YPRIGVYKY--L----------------------------------S---EE-KN-------------CHVVTF----DYQGFG------DSDC-YPNE---NNIMED--GLLV----------------------------------------------W-----------------------------K--WIKEM-------------------------------------------------------AP------------------------------------------------------NAR----V-YL--W-G--HS-----------------LG-----------------------------S-GAATH---LTLTLQSLGT------APYAVLLDAPFTNMVEAAYNHPFGLP-FKPL---GEIFYSYMHENH-------------------------------------------------------------------------------------------------------------------------------SS------------------------------------------------ID-------------------------------------------------------------------------------------------------------------------------------------------------------------------------RILHI----------------------------------------------------------EC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-------------------------------IM------------------------------------------------------IFHSH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDY--I----------------I--------------PYHLGRKL---------YET-AVSKRN---------------------SKSGKVTF--VNCG----------------------------------DQ------AHK---------YNY-LSKELRKAVK------------------------------------------- 354
355 --------------------------------------------------------------------------PYVFA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------APQIPAE----QTWAD----------------RADDVLALLDELIAS---Q--------------------------------------------------------------P----------------------------------------------V-------------------------------------------------------------------------------------------DPA--------------------------------------------------------R----V-IL--A-G--FS-----------------LG-----------------------------S-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGIWHVA-----A--------------LH-------------PNRFAGLVPVSGRV-----------PKTLGESELAALKDIPVQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-----GGQDK--NLPI-----------------------------------------------------------------------------------------------EDTENFVERLRKVGGK-VDLT-----------VLPEGDHFIADEVYSDPKLQQWLV-------------------------------------------------- 355
356 ---------------------------------------------------------------------------LILY----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------------------------------------PYS---TVLNEYKNVFIFFAACGFDVLCIN---YI--G-----------------------------------------------SLSFSDKPNILN----------------------------------------------GFINSIEID----DIMQTFKEFYSYFGDYDG-----------------------------------------------------------------------------------------------------------------------------V-YL--Y-G--GS-----------------YG-----------------------------GFAACSILTKYN-IFKSCCVINGVYEWVLSAYSSDSPDFFINMPLNKNCEYDCKFDNMQDYANTYKMSPIHFV---------------------------------------------------------------------------------------------------------------------------ENITTP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIVC-----SRNDK--RVSYYNSVSLYNRLRALNKKCKFLLF-----------------------------------------------------------------------------------------------------------DESNHSIDNYLHQETMLMNVILWF------------------------------------------------ 356
357 --------------------------------------------YENENSFLNDIQEKNFSLSNFNLFNKKKLRNLILY----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------------------------------------PYS---IILNEYKNIFIFFAASGFDVLCVN---YI--G-----------------------------------------------SLTFSNKLNILS----------------------------------------------GHINSIEID----DIINIFKDFVNYFGDYEN-----------------------------------------------------------------------------------------------------------------------------I-YL--Y-G--GS-----------------YG-----------------------------AFASCALLTKYNSLFKSACIINGVYEWILSTYSSDVPDFFLNITRNKFSEYDYNLSK-EDYTLLYDMSPINYA---------------------------------------------------------------------------------------------------------------------------HNISSP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIIC-----SKDDK--RVSYHNSIALYNKLRALKKKCKLFLF-----------------------------------------------------------------------------------------------------------QNTNHSIDNYSYDETMLLNIILWFYD---------------------------------------------- 357
358 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-----------------------------K--WL------TEYGKKTKLY-----------------------------------------NPQ--------------------------------------------------------S----L-YL--C-G--HS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-IISLLSL-----D--------------QS-------------YL-NNVGVQ---SSNVKAAISISGVYDLGWLSRSVLKQFY----LNP-----------AF------------------------------------------------------------------------------------------------------GNDP-------AT---WVK-------------------------------------------------------------------------------------------------------A-------SP---------------------------------------------------------------------------------------------------------------Y-------------NHITR--AKSEITP-------P-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-N-----PKHDF--LP------------------LLNDAN---------------------------R-FMA----------SLRKNNFRCKHFITPN-----------------R----------------------------------NHLTIMKEFGLKE-------------------------------------------------------- 358
359 -------------------------------------SVVYGNQPRNRL-------------------------DLYIP----------------------------------------------------------------------K--------------------D------------------------------------------------------------------------------------------------------------------------------------------HSK-----------------------------------------------------------------------------------------------------------------------------------------------PHPV---------VAFVTGGAWI--------IGYKAWGALLGRRLAERGIM---VACIDYRNFP--QGTIGDMVTDASE-----------GIAFICESIASFGGD---------------PNQI----YL--M-G--QS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-IA--AC-----------------------SLLEQAVKE-SKGEEIYWSVTQIKGYFGLSGGYNVQNLVDHFH-----ERGLYRSIFLS----------IMEGRRSLADF---------------------------------SPEIVAKKL-SPEAIA------------------L----LPQVV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----GTGDY--SIPSSASETFADVLKQAGAKARLQLY-----------------------------------------------------------------------------------------------------------KGKTH----------TD------VFVQDPLRGGKDPLVEDVV------------------------------ 359
360 -------------------------------------SIVYGEQPRNRL-------------------------DLYIP----------------------------------------------------------------------K--------------------D------------------------------------------------------------------------------------------------------------------------------------------NTR-----------------------------------------------------------------------------------------------------------------------------------------------PCPV---------MAFVTGGAWI--------IGYKAWGALLGRRLAERGII---VACIDYRNFP--QGTISDMVADASQ-----------GISFVCNNIASYGGD---------------PNQI----YL--M-G--QS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-IA--AC-----------------------ALMEQAVKE-SSGQPISWSVTQIKAYFGLSGGYNIYNLVDHFH-----QRGLYRSIFLS----------IMDGEESLSRY---------------------------------SPEIVVKES-SPQTIA------------------L----LPPIV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----GTDDY--SIPSSASQTFVDVLQQVGAQARLLLY-----------------------------------------------------------------------------------------------------------EGKTH----------TD------IFLQDPLRGGKDPLVEDVL------------------------------ 360
361 -------------------------------------SIVYGDQPRNRL-------------------------DLYLP----------------------------------------------------------------------K--------------------N------------------------------------------------------------------------------------------------------------------------------------------STG-----------------------------------------------------------------------------------------------------------------------------------------------PKPV---------VAFVTGGAWI--------IGYKAWGSLLGQQLSERDII---VACIDYRNFP--QGSISDMVKDASS-----------GISFVCNHIAEYGGD---------------PDRI----YL--M-G--QS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-IA--AC-----------------------TIVEQVIKESGEGDSVSWSSSQINAYFGLSGGYNLLNLVDHFH-----SRGLYRSIFLS----------IMEGEESLRQF---------------------------------SPELVVQNPNLKHIIA------------------R----LPPFI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----GTDDY--SIPSDASKSFAETLQRLGAKAKVILY-----------------------------------------------------------------------------------------------------------EGKTH----------TD------LFLQDPMRGGIDEMFEDIV------------------------------ 361
362 GYRWITRLLALACYAMLLMPGFLQVAYLYFFSSQVRRSIVYGGHPRNRL-------------------------DLYIP----------------------------------------------------------------------P--------------------T------------------------------------------------------------------------------------------------------------------------------------------SDG-----------------------------------------------------------------------------------------------------------------------------------------------LKPV---------VVFVTGGAWI--------IGYKAWGSLLGLQLAERDII---VACLDYRNFP--QGTISDMVSDAAQ-----------GISFVCNNISAFGGD---------------PNRI----YL--M-G--QS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-IS--SC-----------------------ALFEQAIKE-SRGESISWSVSQIKAYFGLSGGYNLFNLVEHFH-----NRGLYRSIFLS----------IMEGEESFKQF---------------------------------SPEVRLKDLNVRKAAA------------------L----LPHII----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----GSADY--SIPPEASKTFTDALQAAEVKAELVMY-----------------------------------------------------------------------------------------------------------KGKTH----------TD------LFLQDPLRGGKDELFDHIV------------------------------ 362
363 -------------------------------------SIVYGDQPRNRL-------------------------DLYLP----------------------------------------------------------------------S--------------------N------------------------------------------------------------------------------------------------------------------------------------------NDG-----------------------------------------------------------------------------------------------------------------------------------------------LKPV---------VVFVTGGAWI--------IGYKAWGSLLGMQLAERDII---VACLDYRNFP--QGTISDMVTDASQ-----------GISFVCNNISAFGGD---------------PNRI----YL--M-G--QS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-IA--AC-----------------------ALLEQATKE-LKGESISWTVSQIKAYFGLSGGYNLYKLVDHFH-----NRGLYRSIFLS----------IMEGEESFEKF---------------------------------SPEVRLKDPVVGKAAS------------------L----LPPII----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----GSSDY--SIPCDESKTFTDALQAVGAKAELVLY-----------------------------------------------------------------------------------------------------------SGKTH----------TD------LFLQDPLRGGKDELFDDIV------------------------------ 363
364 -------------------------------------SVVYGEQPRNRL-------------------------DLYIP----------------------------------------------------------------------T--------------------G------------------------------------------------------------------------------------------------------------------------------------------TTE-----------------------------------------------------------------------------------------------------------------------------------------------SKPV---------VAFITGGAWI--------IGYKGWGALLGRRLAERGIL---VACIDYRNFP--QGTIGDMVEDASQ-----------GISFICNNIASYGGD---------------PERI----YL--V-G--QS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-IA--AC-----------------------TLLNQAIKECGEGDTSTWSIAQLKAYFGISGGYNLLNLVDHFH-----RRGLYRSIFLS----------IMEGEESLKKF---------------------------------SPQVMVKESASRSALP------------------L----LPHIF----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----GTSDC--SIPCAESQAFLDALQQHGAKADLFLY-----------------------------------------------------------------------------------------------------------EGKTH----------TD------LFLQDPLRGGRDKMLEEIV------------------------------ 364
365 ------------------------------------------------------------------------------Y----L-------H---------------------------------------------------------------------------------------------------------------------------------GNASNQLE------------GRFAVSLFVPLGIS-----V----------------------------------------SC------F-D---FI-GCGASEGD-----------------------------Y-VTLGHF------EVDD--TNTL----------------------------------------------I-----------------------------E--QICDT-FNC-----T-----------------------------------------------------------------------------------------------------KF-------AI--W-G--RS-----------------MG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-TAILYAA-----K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YKTPKAIV----------ADSSFTSLVDLAKQI--AKQRLIPESIFNSLFPSIKEQILKQLDFDVD------------------------------------SLDIIEAVKQVTIP-----------IT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-H-----GEKDN--FINPMNSQILYSLCP--SNDKNLKIV----------------------------------------------------------KG--------------------------------------------------SH------------------------------------------------------------------- 365
366 --------------------------------------------------------------------------PVVFY----L-------H---------------------------------------------------------------------------------------------------------------------------------GNASNQLE------------GRFCVSLFIPVGVH-----V----------------------------------------CC------F-D---YI-GCGESEGK-----------------------------Y-VTLGYY------EVDD--TKSV----------------------------------------------I-----------------------------D--QVRAT-FKC-----T-----------------------------------------------------------------------------------------------------KY-------AL--W-G--RS-----------------MG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-TALLYAA-----K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YHDVSSII----------ADSAFISITDLCRSV--AKSKNIPDSLYNSLMPHIHQKIIEKTGFDIN------------------------------------NLNILDEAKNITCP-----------VI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FV-H-----GQDDD--FICPSNSQSLYSLCG--SNEKRLRIV----------------------------------------------------------EG--------------------------------------------------KHNT---DRSEA--------------------------------------------------------- 366
367 ------------------------------------------RRPISFENSKKQKIIGSFFSPREQIPE----MSCIIY----L-------H---------------------------------------------------------------------------------------------------------------------------------GNASSQHE------------GMFLAPIFIPYGVA-----V----------------------------------------LT------F-D---FS-GCGLSDGQ-----------------------------Y-ISLGYF------ERDD--VTCA----------------------------------------------I-----------------------------D--FVRKN-FNV-----G-----------------------------------------------------------------------------------------------------RV-------AL--W-G--RS-----------------MG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-TTLYALA-----D--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPTIAAAV----------IDSPFASLPDLVKEI--AAKVHVPGFIASIAKSLIAKKIRELANFDIS------------------------------------KLVPIEAAPSCFSP-----------AR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FV-H-----GEQDD--FISKTHSEKIFEKYS--GEDKEIFIV----------------------------------------------------------PG--------------------------------------------------KHNS---QRP----------------------------------------------------------- 367
368 ------------------------------------------------QNKRNLRLIGSVYYLEE-KPI-ISGDPCVIY----L-------H---------------------------------------------------------------------------------------------------------------------------------GNASSQLE------------GRFLIPNLCPHGIA-----V----------------------------------------FC------F-D---FA-GCGESDGE-----------------------------Y-ISLGYY------ESFD--TKFL----------------------------------------------I-----------------------------N--LLTVQ-FGF-----S-----------------------------------------------------------------------------------------------------KF-------IL--W-G--RS-----------------MG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-TALL--V-----H--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HPSVVACI----------SDSAYISVESMVETI--SKKTDIPFLFRPFASWLLKESVDSTAFFDYR------------------------------------EINVLESIKKIKVP-----------VI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IG-H-----AENDQ--IVPFEHSQLLYQACP--NVMKLFMKL----------------------------------------------------------PG--------------------------------------------------GHNS---PRP----------------------------------------------------------- 368
369 ------------------------------------------RIPFELKNSRGLKIIGSIYMATK----KISGNPAVLY----L-------H---------------------------------------------------------------------------------------------------------------------------------GNASSQRE------------GAFLTRHYYDLGIS-----V----------------------------------------VC------V-D---LS-GSGMSEGE-----------------------------T-LGMGYT------ERDD--VRCI----------------------------------------------I-----------------------------N--FIRQT-YGI-----E-----------------------------------------------------------------------------------------------------NV-------AL--F-G--RS-----------------MG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-TAAWFAC-----E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTDISGII----------CDSSYISLWDVLMDF--TSRNIFLRGLAYILYPYVDNAVKKYGNFSMN------------------------------------DINYRDELKNATIP-----------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FV-H-----AYQDN--FVGINESQEIFSLYG--SKEKFLLTI----------------------------------------------------------EG--------------------------------------------------GHNN---ARKRYVLEQEIVFLCNV--------------------------------------------- 369
370 ------------------------------------------RLDLELSNERNQTLKCSHYVPSV-IPE-NTALPCVIY----C-------H---------------------------------------------------------------------------------------------------------------------------------GNSGCRAD------------ANEAAVILLPSNIT-----V----------------------------------------FA------L-D---FA-GSGLSGGE-----------------------------Y-VSLGWH------EKQD--LKCV----------------------------------------------V-----------------------------S--FLRNN-KEV-----S-----------------------------------------------------------------------------------------------------CI-------GL--W-G--RS-----------------MG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-TSLLYGA-----E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPSIAGMV----------LDSAFSNLYDLMLELVDVYKIRVPKFTVKMAVQYMRRVIQRRAKFDIM------------------------------------DLNVVQFAPKTFIP-----------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FG-H-----ASNDM--FIQSHHSDRIHQTYA--G-DKNLIKF----------------------------------------------------------DG--------------------------------------------------DHNS---PRPQFYYDSVSIFFYNVL-------------------------------------------- 370
371 ------------------------------------------RLDLELTNARGHTLKCSHYVPAF-IPE-NTALPCVIY----C-------H---------------------------------------------------------------------------------------------------------------------------------GNSGCRAD------------ANEAAVILLPSNIT-----V----------------------------------------FT------L-D---FS-GSGLSDGD-----------------------------Y-VSLGWH------EKED--LKSV----------------------------------------------V-----------------------------S--FLRTN-KQV-----S-----------------------------------------------------------------------------------------------------RI-------GL--W-G--RS-----------------MG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-TSLLYGA-----E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPSIAAMV----------LDSAFTNLHGLMLELVDVYKIRVPKFTVKMAVQYMRRVIQKRAKFDIM------------------------------------DLNVIKLAPKTFIP-----------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FG-H-----GLNDM--FIQPHHCDRIHQAYG--G-DKSIVKF----------------------------------------------------------EG--------------------------------------------------DHNS---PRPQSYYDSVSIFFYNTLR------------------------------------------- 371
372 ------------------------------------------RQDLELTNSRGHTLRCSHYVPSS-SRE-DTPLPCVIY----C-------H---------------------------------------------------------------------------------------------------------------------------------GNSGCRAD------------ANEAVMVLLPSNIT-----V----------------------------------------FT------L-D---FS-GSGLSEGD-----------------------------Y-VSLGWH------EKDD--LKTV----------------------------------------------V-----------------------------S--YLRNS-NQV-----S-----------------------------------------------------------------------------------------------------RI-------GL--W-G--RS-----------------MG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-TSLLYGA-----E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPSIAGMV----------LDSAFSNLFDLMMELVDVYKIRLPKFTVKVAVQYMRRIIQKKAKFNIM------------------------------------DLNCVKVSPKTFIP-----------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FG-H-----ASGDK--FIQPHHSDLILKCYA--G-DKNIIKF----------------------------------------------------------DG--------------------------------------------------DHNS---SRPQSYYDSVLVFFYNVLR------------------------------------------- 372
373 ------------------------------------------RKDLEVINGQGKKLQCSHYMPVV-MPE-GKPLPCVIY----C-------H---------------------------------------------------------------------------------------------------------------------------------GNSGCRAD------------ASEAAIILLPTNIT-----V----------------------------------------FT------L-D---FS-GSGISEGE-----------------------------H-VTLGWN------ERED--LKAV----------------------------------------------V-----------------------------N--YLRTD-GNI-----S-----------------------------------------------------------------------------------------------------CI-------GL--W-G--RS-----------------MG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-TSLMYGA-----E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPSIAGMV----------LDSPFSNLVDLMMELVDTYKYPLPKFTVKLAIQHMRKIVKRKASFDIM------------------------------------DLDTIQVAKRCFVP-----------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FG-H-----ATEDD--FILPHHSDKIYESYV--G-DKNIIKF----------------------------------------------------------DG--------------------------------------------------DHNS---PRPQFYFDSITIFFHNVL-------------------------------------------- 373
374 ------------------------------------------RKDLEVKNSRGDVLQCSHYMPVE-RPE-GKPLPCVIY----C-------H---------------------------------------------------------------------------------------------------------------------------------GN---RAD------------GSEAAIVLLPSNIT-----V----------------------------------------FT------L-D---FS-GSGLSGGE-----------------------------H-VTLGWN------EKDD--LKAV----------------------------------------------V-----------------------------E--FLRQD-GNI-----S-----------------------------------------------------------------------------------------------------LI-------GL--W-G--RS-----------------MG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-TSLMYGV-----E--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPSIAGMI----------LDSPFSDLVDLMMELVDTYKFRLPKFTF------MRRAIQKKAKFDIM------------------------------------ELNTIKVAKASFVP-----------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FG-H-----ALDDD--FIRPHHSDRIYEAYV--G-DKNIIKF----------------------------------------------------------PG--------------------------------------------------DHNS---PRPPFYFDSINIFFHNVLQ------------------------------------------- 374
375 ------------------------------------------RNDFELINPRGHSIQCSHFKQSE-YWETGEKQPCVIY----C-------H---------------------------------------------------------------------------------------------------------------------------------GNSGCRLD------------AMECVRTLLPMNIT-----V----------------------------------------LV------F-D---FS-GSGLSGGQ-----------------------------Y-VSLGYF------EKED--VGVI----------------------------------------------V-----------------------------K--HLRDT-GKI-----S-----------------------------------------------------------------------------------------------------TI-------GL--W-G--RS-----------------MG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-TSILYAR-----D--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DPSIAGMV----------LDSPFSSLYKVAEELVHSAVQKLPKLMISLGLKMVRGSIKKRAHFDIK------------------------------------ELDVLNIADQVYIP-----------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FA-H-----GESDN--FVRPHHSEKLFEKYN--G-DKNRLLL----------------------------------------------------------KG--------------------------------------------------GHNS---ERPNFFLESVCIFFQNTLK------------------------------------------- 375
376 NPNLNGVAWSAGS-RLVNYVTEKGDSLQGALYLPAGY-------------------------------QEGKQYPTLTF----I-------Y---------------------------------------------------------E--------------------L----------------------------------------------------------------------------------------------------------------QSDNLNSFYSPTFSSSPNAL------IGV---HTSRG-------------YAVFLPDIVYKLNDPGMSAVWSVVPAVKAAI---RTGVVD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAN----V-GL--H-G--HS-----------------WG-----------------------------GYQTS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LVTQT---------------------------------------NIFKSAVAG--------------------------------------------------------------------------APLTDMISMYSSVYWNTGGANQGIFQSSQGRFKGNFIENREAYERNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNRFADKVK--------------------T-PLV------------------------------------------------------ILHDDKDGAVDFNQG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ITYYNTLRQ-----LNKD--------------------------------------------------------------------------------------------VILLEYV-------------------------------------G-ENHGLSQLRNRRDYSQRLMEYWD----------------------------------------------- 376
377 --------------------------------------TRGLKVVLNQSYGPDTRNKLDVYAP-----QNAQGAPTILF----I-------H---------------------------------------------------------G--------------------G-----------------------------------------------------------SWQGGDKSG--HAFVGESLARAGYV-----V----------------------------------------GV------M-N---YR-LA----PQ--------NRYPS------------------------------YVQD--GAAA----------------------------------------------L-----------------------------K--WL-RD-HAGQFGG----------------------------------------------NPN--------------------------------------------------------N----L-FV--S-G--HS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-NAVELVD-----N--------------AR-------------WL-AEVNVP---VSSIRGVIGIAGPYS-----------------YDF----------RAY------------------------------------------------------------------------------------------------------QTRV-------AF---PEN-------------------------------------------------------------------------------------------------------GNP--DDIMP---------------------------------------------------------------------------------------------------------------D-------------RHVRP-------DAP------P-------------------------HL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-V-----AANDS--VVA-------------------PQNA---------------------------LNMEA----------ALQKARIPVQRVVLPR-----------------L----------------------------------NHVTIIGAVARNLTWLGGTRAEI---------------------------------------------- 377
378 ----------------------------ITDVGEAQIQLH-FPAGWSP-QDRRTALC------I---FP--------------------------------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GYA-----I----------------------------------------QA------I-E---KE--G----SRIAGWAAEHGMVGVVVKYRVSGTGNALGKFP-------G-----PLLD--ARQA----------------------------------------------L-----------------------------R--TVRKN-ASS-------------------------------------LG---I-------APL--------------------------------------------------------R----I-GV--M-G--FS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LAA------------------------------------------MASTL------------------------WNRTLPEEAENPLKNISARPDFS--MFI------------------------------------------Y-----PVITMAP-----------------H------------------------------------------------------------TTH----------------------------------------------------------------------------GGTRNKILGAHPSPALEEMCSA----ER--Q-------------------------------------------------V--TEQ-AP--------------------------------------------P------------------------------------------------------------VF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----ALDD---GVSC-ANSR-----------LME-QA-C-----REK-----------------GV-------P-------------ASLNFY--PT-------------G------------------------------------GHGYGME---------------KRGHPTDQWPE------------------------------------ 378
379 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E----------------------------------------LS------I-D---AQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R----I-GV--M-G--FS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LAA-------------------------------------------SLSN------------------------LYSEVKQDYDDELEKMSARPDLS--VLC------------------------------------------Y-----PVISW-G-----------------E------------------------------------------------------------FAH----------------------------------------------------------------------------LGSKENLLGQQASEALVAKTSM----EN--A-------------------------------------------------V--HAK-TP--------------------------------------------P------------------------------------------------------------SF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IW-H-----TVEDG--TVPV-ENAY-----------LYA-MA-L-----QKH-----------------KI-------R-------------HELHVY--PD-------------G------------------------------------RHGLGLA-----------------KDLARSSN------------------------------------- 379
380 PGEPAHPAPEVNTTTAKSDLVAGRTVIRLGNVSDPTLTLY---K---PRHNSGAAIL------V---FP--------------------------------------------------------------------------------G--------------------G---------------------------------------------------------------------------------AYQ-----V----------------------------------------LA------I-D---LE--G----TEVCHWVNSIGVNCILVKYRVP-DTGPYPRSA-------A-----ALQD--AQRA----------------------------------------------M-----------------------------G--LVREH-AAT-------------------------------------WH---I-------DPH--------------------------------------------------------R----I-GV--L-G--FS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LSA------------------------------------------ALSTH------------------------FQKRLYAPV-DAADQLSCRPDFE--MLI------------------------------------------Y-----P---------------------------------------------------------------------------------------------------------------------------------------------------------------------------GWLALAEKHMEPNP----SL--P-------------------------------------------------V--TAN-TP--------------------------------------------T------------------------------------------------------------AF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-Q-----AEDD---PVHV-ENVI-----------EYF-LA-L-----KHA-----------------GV-------P-------------AEMHVY--AK-------------G------------------------------------GHGYGLRPTPVSVSIHDMPPTSTTPLPITHWPSLAATW------------------------------- 380
381 PNSNGLTGGEKEVSPH-----------RLSNVTAPTITVYRAPQ---P---NGMAVI------M---CP--------------------------------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GYS-----R----------------------------------------LA------M-D---HE--G----HDMASWFCGQGITYVVLKYRMP-NG----HCE-------V-----PLSD--AERA----------------------------------------------I-----------------------------R--IVREH-AGE-------------------------------------WN---I-------HPR--------------------------------------------------------K----I-GI--M-G--AS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LAS------------------------------------------TLATH------------------------YSA-------------ASRPDFQ--ILL------------------------------------------Y-----PVVTMTQ-----------------S-------------------------------------------------------------TH----------------------------------------------------------------------------GGSRKELLGGNPTAEQEVLFSN----EL--Q-------------------------------------------------V--TSD-TP--------------------------------------------Q------------------------------------------------------------AF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-L-----SSDDG--AVPP-SNGV-----------NYY-LA-L-----QKN-----------------NV-------P-------------ASLHVY--PT-------------G------------------------------------GHGWGFR--------DNFKYKQQWTQELEKW-------------------------------------- 381
382 ------------------------------DIEQPSLRVF-LPA---PELATGRAVV------A---CP--------------------------------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GYS-----G----------------------------------------LA------V-N---HE--G----YDWAPYFNKQGIALIVLKYRMP-KG----DRT-------L-----PISD--AEAA----------------------------------------------M-----------------------------K--MVRDS-ADV-------------------------------------WN---L-------NPN--------------------------------------------------------D----I-GI--M-G--SS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LAS------------------------------------------TIATH------------------------APE-------------ALRPNFQ--ILF------------------------------------------Y-----PVITMDK-----------------S------------------------------------------------------------FTH----------------------------------------------------------------------------MGSHDNLLGKDASADLEKEFSN----EK--Q-------------------------------------------------V--TKE-TP--------------------------------------------R------------------------------------------------------------AF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-Y-----SDDDK--VVPP-ANGV-----------NYY-LA-L-----NKK-----------------GV-------P-------------SVLHIY--PT-------------G------------------------------------GHGWGIR--------EDFLYKSEMQNELTSW-------------------------------------- 382
383 ------------TTYDLSKVDNAELIGIVENASEGTLFVFTCDR---P---NGSSVI------M---CP--------------------------------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFL-----K----------------------------------------TN------L-E---NE--G----IDFAEWFTKLGITYIVFKYRMP-HG----NPD-------V-----PEQD--TRLA----------------------------------------------L-----------------------------K--VVREK-FPE-------------------------------------F-------------CD--------------------------------------------------------K----L-GV--M-G--AS-----------------IG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LAT------------------------------------------FSATL------------------------LPD-------------DEKPDFQ--ILM------------------------------------------Y-----PVVSVDD-----------------R------------------------------------------------------------LTH----------------------------------------------------------------------------FPCRERMFGHSYSPDKMEQYSP----IE--H-------------------------------------------------I--TSG-TP--------------------------------------------A------------------------------------------------------------AF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-A-----AADDA--VVSP-LNGI-----------MYA-AR-L-----QKA-----------------DI-------P-------------ISLHIY--PA-------------G------------------------------------GHGFGYN--------DSFVYKQEWLQELGEW-------------------------------------- 383
384 -----------------------------------QLIIFL------PDKPNGTGIL------I---IP--------------------------------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GYQ-----A----------------------------------------VM------L-D---KE--G----TALAPEFLSQGYTLFVLSYRLP-SPAEGENIN-------K-----TFID--AISA----------------------------------------------M-----------------------------L--YIRKN-ADK-------------------------------------WH---L-------QRH--------------------------------------------------------R----I-GV--L-G--FS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-IAS------------------------------------------TFVNQ------------------------ICD-FKRSSDSKEQEIFAIPDFV--GLI------------------------------------------Y-----PVISMKD-----------------D------------------------------------------------------------VTH----------------------------------------------------------------------------PGSRKQLLGDNSTSENIIQYSA----DL--N-------------------------------------------------V--TSC-FP--------------------------------------------P------------------------------------------------------------VF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----CCDDD--LVSI-ENSL-----------LMY-RG-L-----IEK-----------------GV-------S-------------AEMHLY--EK-------------G------------------------------------GHGFSIQ--------------WATDLPVG---------------------------------------- 384
385 YRENIYSLDNYERYITDSSLFENTGDGIIYTGIVPLITVVE------PVVSNQHSVL------I---IP--------------------------------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GYR-----R----------------------------------------IV------Y-E---RE--G----LDVGRWIAGQGYTAFILSYRMP-S------VN-------G---YYSFAD--AKNA----------------------------------------------L-----------------------------N--FI-----SY-------------------------------------WA---G-------MSE--------------------------------------------------------RTFKSV-GC--M-G--FS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LAG-------------------------------------------YITH------------------------L---------HYEEETSVRPDWM--ALI------------------------------------------Y-----PVISLDR-----------------S------------------------------------------------------------IAH----------------------------------------------------------------------------QGCRKRLL-DAGESE----YSA----SLENS-------------------------------------------------V--TEY-MP--------------------------------------------P------------------------------------------------------------VF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-H-----ATDDK--DVPV-IHSL-----------RYF-NS-I-----RDK-----------------GH-------H-------------AEAHFF--DK-------------G------------------------------------GHGFGVS--------------GKNGYPIEKWQSLLLE-------------------------------- 385
386 ----------------------------------PELYVMLPKK---P--TTSAAVL------V---IP--------------------------------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GYE-----F----------------------------------------VA------L-G---HE--G----FQIGEWLRAQGMPAIVLDYRVA-----PYHYP-------V-----EIED--GMRA----------------------------------------------M-----------------------------R--VIRAH-AKE-------------------------------------WG---I-------DPN--------------------------------------------------------R----I-GV--W-G--SS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LAS------------------------------------------TLGTH------------------------CNK-MNPNAADPIDRLSCKPDFM--VLA------------------------------------------Y-----PVISMRK-----------------S------------------------------------------------------------ITH----------------------------------------------------------------------------MGSRNALLGKNPSPALVKKYSN----EL--Q-------------------------------------------------V--SPS-TP--------------------------------------------P------------------------------------------------------------TF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LF-A-----TERDP--VVPI-HNSI-----------DFY-NA-M-----IRN-----------------GV-------P-------------GELHIF--DY-------------S------------------------------------NHGCGLC---------------GSIIPLRAWPGLL---------------------------------- 386
387 ------------------------------------LAYYPAP----ENNGLGVAVL------V---LP--------------------------------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GYS-----Y----------------------------------------VS------L-D---RE--G----TNSTTYLNAKGYDAWVLDYSTA-ETAATPLYP-------V-----PLEE--ALGA----------------------------------------------V-----------------------------R--YIR----SQ-------------------------------------KR---V-------KVD--------------------------------------------------------K----L-GI--W-G--YS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LAA------------------------------------------VTVTN------------------------PEADL---------------DFG--ILT------------------------------------------Y-----PVISMDA-----------------A------------------------------------------------------------ITH----------------------------------------------------------------------------NGSRTNLLGDNPPEKLVKKMSA----ET--R-------------------------------------------------V--TDK-TP--------------------------------------------P------------------------------------------------------------IF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IY-H-----SANDA--TVPV-ENAL-----------RFI-NA-L-----TEK-----------------DR-------P-------------YQALIL--PD-------------A------------------------------------AHGIALA----------------LDDPQRNWTPEL---------------------------------- 387
388 --------------------------------------------QLNKENGDSLMDVHFFYPNGYEQNPVDHKYKAIFY----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GF-MVDGI--KKLPREISDRTNSILIYPDYGLTPEFKYPLGLKQCY----QLFTDIMNGN-------------------------------------------------------FNPFND-------------------------------------------------------------------------------------LINDS----------------------------------------------------------------------------------------------------------------------I-SI--V-G--ES-----------------SG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-FALSLPLMLKLNN--------------ST-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKISKVLVYYPITDCNFETPSYNRFSEKFYLTKEGMKWCWNHYTNNDSDRDEITCCPLKATIDQLKDFPETLVIT-----AETDV--LSSEGEQFGLKLSNANVKVSVLRILK-------------------------------------------------------------------------------------------------------------TIHGFVSLDQTNDSIACRVGMDLS---------------------------------------------- 388
389 --------------------------------------------QLNKENGDSLMDVHFFYPSGYEQNPVDHKYKAIFY----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GF-MVDGI--KKLPREISDRTNSILIYPDYGLTPEFKYPLGLKQCY----QLFTDIMNGN-------------------------------------------------------FNPFND-------------------------------------------------------------------------------------LINDS----------------------------------------------------------------------------------------------------------------------I-SI--V-G--ES-----------------SG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-FALSLPLMLKLNN--------------ST-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKISKVLVYYPITDCNLKHHPIIDLRES--INKGSMKWCWNHYTNNDSERDEITCCPLKATIDQLKDFPETLVIT-----AETDV--LSSEGEQFGLKLSNANVKVSVLRILK-------------------------------------------------------------------------------------------------------------TIHGFVSLDQTNDSIACRVGMDLS---------------------------------------------- 389
390 -----------------------------------------------------------------------NKLPAIHY----S-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWVMGDHVTHDKLIREICYRTNSLVIFTEYSRPPEVKYPIQNEQCYAVILKFIKDAAKWN-------------------------------------------------------I----D-------------------------------------------------------------------------------------LNN------------------------------------------------------------------------------------------------------------------------F-SL--V-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-MAIVLGLMAKVRN--------------GP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRIC---LYYPAIDSGMNSGSYKEFHNDFYLTKDGMKWFWDAYTNSPKDTNEIYCSPSKCKESDVMGFPETMIIN-----GEADV--LRDEGENFARLLRKANVPVTHLRIQA-------------------------------------------------------------------------------------------------------------MVHDFVALNCLDQSKACRVAMDSS---------------------------------------------- 390
391 -------------------------------------MDIIKPVTQNKLP------------------------V-VLF----V-------T---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFV--------------------GS-LKSNYLQQR---LEIAEAGYVV-AS------I-E---YR-KI----PN-----------------------------------GVF---PEPLED--VKSA----------------------------------------------I-----------------------------R---FLRA-NA------------------------------------DKFG---I-------DKN--------------------------------------------------------K----I-AV--M-G--SS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LVA-----------------------------------------------------------------------------------------------------------------------------------------------------MAGTT-----------------N------GYKQFDKGDNLNQNSDVQAVIDIYGLSDLATVGEDFSKEIQEIHKSSAAPEAL-WLNGVV--------------------------------------------------------------------------------------LSNEINS-VDNMPEKVKA-------------------------------------------------A--NPM-----------------------------------------------TYITKDTP---------------------------P-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GDKD---ILVSPSQTE-----------KLH-KA-L-----VTK-----------------GIDS--------------------TRYIV--KG-------------A------------------------------------AH------------------------------------------------------------------- 391
392 ----------------------------------KLEMDIIKPVTQKKLP------------------------A-VLF----V-------T---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFV--------------------GS-LKSNYLQQR---LEIAEAGYVV-AS------I-E---YR-KI----PN-----------------------------------GVF---PEPLED--VKSA----------------------------------------------I-----------------------------R---FLRA-NA------------------------------------DKFG---I-------DKN--------------------------------------------------------K----I-AV--M-G--SS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LVA-----------------------------------------------------------------------------------------------------------------------------------------------------MAGTT-----------------N------GYRQFDKGDNLDQSSDVQAVIDIYGLSDLASIGEDFSKEVQEIHKSPAAPEAL-WLNGIV--------------------------------------------------------------------------------------LSHEINS-VNNIPEKVKA-------------------------------------------------A--NPM-----------------------------------------------TYITKKTP---------------------------P-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GDKD---TSVSPSQTE-----------KLH-KA-L-----VTK-----------------GIDS--------------------TRYIV--KG-------------A------------------------------------AH------------------------------------------------------------------- 392
393 ------------------------------------------------KP------------------------A-IIY----Y-------P---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFM--------------------SS-EHDKFIEMR---MALAEAGFVV-AA------V-E---YR-TI----PD------------------------------------TF---PAPVED--GKAA----------------------------------------------I-----------------------------R---YLRE-HA------------------------------------SNYG---I-------DPQ--------------------------------------------------------R----I-GV--L-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------W-LAQ-----------------------------------------------------------------------------------------------------------------------------------------------------MMGTT-----------------N------GDKTFDKGDFLQQSADVQAVATLYGISDLLNIGEGFPESVQEVHRSPAVTEAL-MINGPA--------------------------------------------------------------------------------------FRNFAGAPITASKEKALN-------------------------------------------------A--SPI-----------------------------------------------GHMKGVKP---------------------------P-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IM-H-----GSKD---TLVSPEQSA-----------KLF-RM-L-----KKN-----------------GDNA--------------------EYVLV--EG-------------A------------------------------------EHGDKTWYQPI---------------------------------------------------------- 393
394 ------------SEHSHWPPPDLELLTDVPFSTHGLALDVLRPRARAT-------E-------P---VP-----A-ILH----F-------H---------------------------------------------------------G--------------------G---------GWVK----------------------------------------FGKWPVA--NTF---L--------ARA-GFV-----T----------------------------------------VS------A-D---YR--L----AP-----------------GATFPAQL--------------------HD--VKTA----------------------------------------------V-----------------------------R--FVR---A-HAAELG-------------------------------------I-------DPQ--------------------------------------------------------R----I-GA--W-G--VS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-L--------------------------------------------AALLGTVSG-EEGPDGGWSS------GGWPGESSAVQA-------------V--GSV------------------------------------------C-----GPLDFF-------------------------------------------------------------------------------DPAWN----------------------------------------------F-GPEPFELLGGPFHERLA------LAR------------------AASP----L--EH-------------------------------------------------V--TPD-AP--------------------------------------------P------------------------------------------------------------FC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GIADD--EVPV-SQSR-----------RMH-AA-LQLMEGRAA-----------------GV-------L-------------SELTEL--DG-------------GHYIN-------------------------------DTHQA-EVEARLLAFFQRTLSFSPCC-------------------------------------------- 394
395 ----------------------------------------------------------------------TDSRPTVVF----F-------F---------------------------------------------------------G--------------------G-------------------------------------------------------------GWSGFNATQFYPQAKYYSSRGLL-----A----------------------------------------IC------A-T---YR-TTSFYKTE-------------------------------------P---WQCVQD--AKST----------------------------------------------V-----------------------------R--HLKVN-AKQLGI-----------------------------------------------DPK--------------------------------------------------------K----L-IV--G-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-IAAATAT-----L--------------KE-------------WN-------------------------------------------NKEDDLSISS--TPS------------------------------------------ALLLFNPVFDNGPGGYGNNEKDSRVKNYWKT--------------------------------------------------------------------------------------------------------------------------------------------------------------FSP-----------------------------------------------------------------------------------------------------------------------------------------LHNLNGKQPP-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VL-M-----GDRDK--HTSA--------------------EK------------------------------------TRLYGDTMKKNNNTCEVIIY--PG-------------Q------------------------------------KH------------------------------------------------------------------- 395
396 --------------------------------------------------LRYNHYPTGKLYVYYSKDQTNQSSPAVIF----F-------F---------------------------------------------------------G--------------------G-------------------------------------------------------------GWNSGSPKQFESQASYLNKYGVT-----V----------------------------------------VL------A-D---YR-TQKNAGTT-------------------------------------P---KEALMD--AKSA----------------------------------------------M-----------------------------R--YLKQH-AMSIHV-----------------------------------------------DPD--------------------------------------------------------K----I-LA--G-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LAAATAF-----C--------------HQ-------------IN-------------------------------------------NPEDDLNVSS--IPK------------------------------------------ALILFNPVIDNGPHGYGFD----RVKDYYRD--------------------------------------------------------------------------------------------------------------------------------------------------------------FSP-----------------------------------------------------------------------------------------------------------------------------------------IHNIKKDAPP-------------------------AI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FF-L-----GSEDN--IVLL--------------------ET------------------------------------ALKFKKKMEHVGSRCDLLLY--PG-------------Q------------------------------------KHGFFNAKFEEFFEKTMSATVVF---------------------------------------------- 396
397 --------------------------------------RAFTPIGEAPEGG--------------------WP-V-MLY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWV-----L---------G--NIDT---ENVVCTN---LCSRGG-CVV-VT------V-D---YR-LA----PE-----------------------------------NPW---PAAVHD--CWES----------------------------------------------F-----------------------------L--WLL----------------------------------SD---GPANLN---I-------NIS--------------------------------------------------------K----I-AT--G-G--SS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------I--IT-----HKAL-----------------TLSPPVRFLAQLLS---V-----PVMD--N-----------------T--------ATVSNNESYRRYEFVPALPAA-KMLWYR---------------------NH-YLPNEK------------------------------------------------------------------------------------DW--SHPEASP----LFYTG-------------------------------------------------D--WS-----------------------------------------------------ALP---------------------------R-------------------------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IM-V-----GELD---VLRS--EGE-----------QYA-EK-L-----KQA-----------------EVEV--------------------DLQVM--KG-------------M------------------------------------PHP--FL---AMDGVLKEGK------------------------------------------------- 397
398 --------------------------------------------------------------------------V-VVN----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFT-----LGGPSD--------------DSRWAQA---VLSEVG-AVV-VS------V-G---YR-RA----PE-----------------------------------HPF---PAAVDD--GVLA----------------------------------------------L-----------------------------Q--YLASH-A-------------------------------------VELG---L-------DIS--------------------------------------------------------R----I-AL--S-G--FS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAV---------------------------------------------------------------------------------------------T--VPLRFRDMLIQAEHEGWLSRADSTVQ--LVSPTASDLHIVALFCWY-----PILD--F-----------------E--------EPREHRRAMSIEPN---KTLPSFFTNLF---------------------DESYLPDLE--------------------------------------------------------------------------------------QRKSPYASP----VH-AT-------------------------------------------------D--DAL-----------------------------------------------RD---SLPH--------------------------D-------------------------IF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FF-I-----CEWD---MLLN--EG------------QLF-CRRL-----QDI-----------------NKHV--------------------RAMMV--EK-------------A------------------------------------RHA--W--------------------------------------------------------------- 398
399 -------------------------------------------SVTDILIPTRDGTEIDGRVFTPVSVPADYRSLMVFY------------H-------------------------------------------------------SSGWCMRGVRDDDSLFKILTPKFG-------------------------------------------------------------------------------------------------------------------------------CVCVS------V-D---YR-------------------------------------------LAPESKFPVAHND--AIDS----------------------------------------------F-----------------------------K--WVASN--------------------------------------------------------------------------------------------------------IEKLGANPKR------GFFLG-G--AS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVLSH-----IARDE--KIKPELTGLWHMVPTLIHPADLDEETMAQFRSYKET----------------------------------------------------------------------------------------------------IHAPVITPKIMDIFFENYQPTPKSPLVNPLYYPTGHKDLPPSFFQCCGWDPLRDEGIAYEKALKAAGNE 399
400 ----------------------------------------------------------------QPTTDKSNPSPVLIT--------------------------------------------------------------------ACG--------------------S---------------------------------------------------------------------------------GFIIPGLGL----------------------DTSYCRLISSKTFHTVIDVG------------YR-LA------------------------------------------PEHPFPCAIEDLVSVVH-------------------------------------------------------------------------------WVRSQ---------------------------------------------------------------------------------------------------------------PSRFDLNRISI--G-G--FS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAASVAVNSFPPG--------------TFWGL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FYPVLDACTPPEMKVAPSEYGSEAGEDG--NRGSGNGKKKPPLGGMGSVPTFM----------MNIMEKCYLVNVFAGAEPKEGSKSELELESDPNATGRNGEDVLKNPRISPAYADANRFPMRCLFVTAEYDCLAKEAEELAERIRVDGVGEERRKVIVHQVQGCGHQF----------------------------------------------------------------- 400
401 ---------------------------------------VYNPGAASKPCS-----------------------V-LIN----F-------H---------------------------------------------------------G--------------------S---------------------------------------------------------------------------------GFV-----FPFHGQ--------------DEEFCRL---MSQRTG-YTV-LD------V-Q---YR-LA----PE-----------------------------------NPF---PAALND--VEDV----------------------------------------------V-----------------------------N--WVLRQ-P-------------------------------------ER-----F-------DRA--------------------------------------------------------R----I-AL--S-G--FS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAL---------------------------------------------------------------------------------------------A----------------------ASST-----LFPRET-FHAVLTF--Y-----PPVD-LY-----------------T--------EP-----GSKTAPDPTGKPLPAPLARFF---------------------DQCYIPSSH--------------------------------------------------------------------------------------DPKDPRISP----YY-AQ-------------------------------------------------P-----------------------------------------------------D---CFPD--------------------------R-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-T-----AAGD---SLAP--EAE-----------QLA-VKIR-----EEA-----------------GREV--------------------VSARM--DG-------------C------------------------------------NHG--WNVSPKNAVERDA--------------------------------------------------- 401
402 ----------------------MIRKRIRIQGVSCIAYEIEKPQN--------------------------DG-L-LIF----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWC-----V---------G--EARY---YDGIMYQ---LCEQIG-CNG-IS------I-D---YR-LA----PE-----------------------------------HPF---PAGLDD--CHAV----------------------------------------------V-----------------------------S--EVCTN-GL------------------------------------LDLP---F-------NRK--------------------------------------------------------R----V-LI--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------V--VCQ----RLHREKKD-------------ILK------GQILI---Y-----PVTH-VF-----------------NF-------TSPSYQDYWKSYAGTALLNPKHMAR--W---------------------ILLYLGIEASKNNIKKVMNSQHALPELAEQKPYSQWLYHLNKRKPEKLVDQHLAKQF-IKLG-----------------------------------TNPDVSP----VF----------------------------------------------------------------------------------------------------------GDTEGLP---------------------------P-------------------------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VL-T-----AGYD---VLKD--EGI-----------QYA-NK-L-----KKS-----------------GVST--------------------EWRHY--PR-------------A------------------------------------FHG--LFNM---PNSKDRNEMMKATVDF----------------------------------------- 402
403 --------------------------DVTVDASRNLWARVYSR-------SSSGSSAVP---------V-P---V-VVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFA-----F---------L--SAASTP-LDGMCRR---LCRELG-AVV-VS------V-N---YR-LA----PE-----------------------------------HKF---PAAYDD--GEAV----------------------------------------------F-----------------------------R--HLA-----------ANNDI------------------FP------V-P---V-------DLS--------------------------------------------------------R----C-FL--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAH---------------------------------------------------------------------------------------------H--VAH----RWTS--DAE----PDPVVF--RLA------GIILL---Q-----PYFG-GE-----------------E--------RTAAELSLE-GVAPV-V-NMR-RSDWSW---------------------KA-FLPVGA------------------------------------------------------------------------------------DRNHPAAHVTG----EA-AP-------------------------------------------------E--PEL-----------------------------------------------GE---NFP---------------------------P-------------------------AM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VA-V-----GGLD---PLQD--WQR-----------RYA-AM-L-----RRK-----------------G--KA-----------------V-RVVEF--PE-------------A------------------------------------IHA--FYCF---PELPDSGKLVEDVKAF----------------------------------------- 403
404 --------------------------DVTIDAAKNLWARVF---------TPPPSTPVP---------L-P---V-VVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GLF-----FFEQVSKFLKL--SAASAP-LDAM-XR---FARALG-AAV-VS------V-D---YR-LA----PE-----------------------------------HHF---PAAYDD--GEAA----------------------------------------------L-----------------------------R--YLA-----------ANDGI------------------FS------V-S---V-------DLS--------------------------------------------------------R----C-FL--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAH---------------------------------------------------------------------------------------------H--VAH----RWTS--DPQAQPSPDP-AL--RLA------GIILL---Q-----PYFG-GE-----------------E--------RTESELSLG-GVAPV-V-NLR-RSDWSW---------------------XA-FFPVAA------------------------------------------------------------------------------------DRNHPAAHVTG----EA-GP-------------------------------------------------E--PEL-----------------------------------------------GE---GFL---------------------------P-------------------------AM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VA-V-----GGLD---PLQD--WQR-----------RYA-AMLL-----RRK-----------------G-KKA-----------------V-RLVEF--PD-------------A------------------------------------IHC--FYMF---PELPDAGKLVEETKAF----------------------------------------- 404
405 ------------------------------------------------------------------------------Y----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFT-----L---------L--SAASAP-MDALCRR---LARALG-AVV-VS------V-D---YR-LA----PE-----------------------------------HPY---PAAYDD--GEDV----------------------------------------------L-----------------------------G--YLA-----------ATNAAS-----------------LP------A-P---V-------DLS--------------------------------------------------------R----C-FL--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAH---------------------------------------------------------------------------------------------H--VAH----RWTS--DDPNNPNPKH-VV--QLA------GIILL---Q-----PYFG-GE-----------------E--------RTGSEISLE-GVAPV-V-NMR-RSDWSW---------------------KA-FLPLGA------------------------------------------------------------------------------------DRNHEAAHVTG----EA-EP-------------------------------------------------E--PKL-----------------------------------------------GE---SFP---------------------------P-------------------------AM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-V-----GGFD---PLKD--WQR-----------RYA-VMLE-----RKN-----------------R-NAA-----------------V-RLVDF--PE-------------A------------------------------------IHG--FYMF---PKLPEAGEVVEKVRAF----------------------------------------- 405
406 ----------------------------------------------------------------------P---V-VVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFT-----V---------F--SAATGP-YDSLCRS---ICLGSG-AVV-VS------L-S---YR-LA----PE-----------------------------------HRF---PAAYDD--GAAA----------------------------------------------L-----------------------------R--FLT-----------TSSAASQ----------------IP------V-P---I-------DLS--------------------------------------------------------R----C-FL--A-G--DS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAH---------------------------------------------------------------------------------------------H--VAH----RFTS--SSSSPP-P---NI--QIA------GIILL---S-----AYFG-GQ-----------------E--------RTESELALE-GVAPI-V-NLR-RSDFWW---------------------KA-FLPAGA------------------------------------------------------------------------------------DRNHPAAHVTG----EA-GP-------------------------------------------------E--PEL-----------------------------------------------GE---AFP---------------------------P-------------------------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-V-----GGLD---PLQD--WGR-----------RYA-AM-L-----RRM-----------------G--KS-----------------V-KVVEF--PE-------------A------------------------------------VHA--FYFF---PALPESARLVEEIKAF----------------------------------------- 406
407 --------------------------DVMVNASTGVTVRVFFA-------APEPTAPSP---------LRP---V-VVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFT-----V---------F--SAATGP-LDALCRT---ICRDAG-AVV-VS------V-S---YR-LA----PE-----------------------------------HRY---PAAYDD--GEAV----------------------------------------------L-----------------------------R--YLA-----------ANAAG------------------LP------V-P---I-------DLS--------------------------------------------------------R----C-FL--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IVH---------------------------------------------------------------------------------------------H--VAH----RWT-----ASPP-PTDTSI--RLA------GVMLI---A-----AFFG-GE-----------------E--------RTDSELALE-GVAPI-M-NLR-RSDFWW---------------------KA-FLPVGA------------------------------------------------------------------------------------DRNHPTAHVTG----EA-GP-------------------------------------------------E--PEL-----------------------------------------------AE---AFP---------------------------P-------------------------AM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-V-----GGLD---PLQD--WER-----------RYA-AM-L-----RRK-----------------G--KA-----------------V-RVVEF--PE-------------A------------------------------------VHG--FYFF---LALPESGKLIAEISAF----------------------------------------- 407
408 --------------------------DFDVDASRDLWARVFFP-------V-SG----P---------APPAP-V-VVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFA-----L---------F--SSSIRY-FDALCRR---LCRGLGAAAV-VS------V-N---YR-LA----PE-----------------------------------HKF---PAAYDD--AMDT----------------------------------------------L-----------------------------L--FLD-----------AHNGA------------------IPNA-G-PL-Q---L-------DLS--------------------------------------------------------N----C-FL--A-G--ES-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IIH---------------------------------------------------------------------------------------------H--VANRXAWAWAAS-DKNNNNKPTRRKL--RVA------GLLSV---Q-----PYFG-GE-----------------E--------RTESELALD-GVAPI-V-SLR-RSDFWW---------------------RA-FLPAGA------------------------------------------------------------------------------------TRDHPAAHVTE----DN-VG-------------------------------------------------L--AE-------------------------------------------------E---GFP---------------------------P-------------------------VM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-V-----GGFD---PLQD--WQR-----------RYA-DV-L-----RRK-----------------G--KR-----------------V-NVVEF--XE-------------G------------------------------------IHA--FYIF---SELADSARAIEEMRAF----------------------------------------- 408
409 --------------------------DFDVDASRGLWARVFSP-------A-DTTV--A---------SRPLP-V-IVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFA-----L---------F--SAANRY-FDALCRR---LCYGIN-AVV-VS------V-E---YR-LA----PE-----------------------------------HRY---PAAYDD--AMDT----------------------------------------------L-----------------------------L--FIN-----------A-NGG------------------IPSLDD-NV-P---V-------DLS--------------------------------------------------------N----C-FL--A-G--ES-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IIH---------------------------------------------------------------------------------------------H--VAN----RWVA------TDQATSNCV--RLA------GLLLV---Q-----PYFG-GE-----------------E--------RTNSELMLE-GVAPI-V-NLR-RQDFWW---------------------KA-FLPVGA------------------------------------------------------------------------------------NRDHPAAHVTG----EN-AE-------------------------------------------------L--SE-------------------------------------------------V----FP---------------------------P-------------------------AI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-V-----GGLD---PLQD--WQR-----------RYA-DV-L-----RRK-----------------G--KM-----------------A-QVVEF--PE-------------G------------------------------------IHA--FYMF---SELADSTKVIEDMRVF----------------------------------------- 409
410 --------------------------DVDLDASRNIWARVFSP-------A-AANAHPP---------SAPLP-V-VVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFA-----L---------F--SPAIGP-FNGVCRR---LCSVLG-AVV-VS------V-N---YR-LA----PE-----------------------------------HKF---PAAYDD--GVDA----------------------------------------------L-----------------------------R--FLD-----------AHDGT------------------IPGL-T-SM-A---V-------DLG--------------------------------------------------------S----C-FL--A-G--ES-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IVH---------------------------------------------------------------------------------------------H--VAN----IWAS------QHQRTSRHV--RLA------GIFPV---Q-----PYFG-GE-----------------E--------RTPSEVRLE-GIAPV-V-NLR-RSDWSW---------------------KA-FLPAGA------------------------------------------------------------------------------------TRDHPAAHVTD----DN-AG-------------------------------------------------L--AE-------------------------------------------------E---GFP---------------------------P-------------------------VM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-V-----GGFD---PLQD--WQR-----------RYA-DV-L-----RRK-----------------G--KR-----------------V-TVAEY--PD-------------G------------------------------------FHG--FYGF---PELDDAWKVLEDMKAF----------------------------------------- 410
411 --------------------------DVVVDAATGVWARVFSP-------SPPPPSAED---------APPLS-V-VVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFA-----L---------F--SPASRP-YDAFCRR---LCRALG-AAV-VS------V-A---YR-LA----PA-----------------------------------HRF---PAPYDD--GLAV----------------------------------------------L-----------------------------R--FLA-----------TSAAQ------------------IP------V-P---L-------DLS--------------------------------------------------------R----C-FL--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAH---------------------------------------------------------------------------------------------H--VAH----RWSS--SSSSAS-----SL--NLA------GVVLI---Q-----PFFG-GE-----------------E--------RTEAELELD-KAIPS-L-SMA-ITDAYW---------------------RD-FLPEGA------------------------------------------------------------------------------------TRDHAAA---------A-CG-------------------------------------------------V--GEL-----------------------------------------------AE---AFP---------------------------P-------------------------AM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VA-V-----GGFD---LLKG--WQA-----------RYV-EK-L-----RGM-----------------G--KP-----------------V-KVMEY--PD-------------A------------------------------------IHG--FHVF---PEIADSGKFLEDLKVF----------------------------------------- 411
412 --------------------------DLVLDPAHGLGARLFFH-------RPTL----A---------AEALP-V-IVF----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFA-----F---------L--SACSLP-YDAACRR---IARYAS-ASV-LS------V-D---YR-RA----PE-----------------------------------HKF---PAPYDD--GFSA----------------------------------------------L-----------------------------R--FLD-----------DPENH-------------------P---S-DV-Q---L-------DVS--------------------------------------------------------R----V-FL--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAH---------------------------------------------------------------------------------------------H--VAR----RYAAA-ESSTFS-----NV--RIK------GLIAI---Q-----PFFG-GE-----------------E--------RTGSELRLD-G-API-V-SVG-RTDWMW---------------------RA-FLPPGA------------------------------------------------------------------------------------DRSHE---AAC----PD-AA-------------------------------------------------A--VEE-----------------------------------------------EE---EFP---------------------------P-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-V-----GGYD---PLQD--WQR-----------RYG-EA-L-----RGK-----------------G--KE-----------------V-EVLEY--PE-------------G------------------------------------IHA--FFLF---PEFSHARDLMLRIAEF----------------------------------------- 412
413 -----------------------------------------------------------------------LP-V-VVF----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFA-----Y---------L--SAASPA-YDAACRR---IARHCA-AAV-LS------V-D---YR-RS----PE-----------------------------------HKF---PAPYDD--GFSA----------------------------------------------L-----------------------------R--FLD-----------NPKNH-------------------P---A-DIPQ---L-------DVS--------------------------------------------------------R----C-FL--A-G--DS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAH---------------------------------------------------------------------------------------------H--VAR----RYAMA-LSS-FS-----HL--RIL------GLISI---Q-----PFFG-GE-----------------E--------RTASELELD-G-API-V-SVS-RCDWMW---------------------RA-FLPPGA------------------------------------------------------------------------------------DRTHEACAAAG----AA-AA-------------------------------------------------A--GVE-----------------------------------------------SA---AFP---------------------------P-------------------------AV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-V-----GGYD---PLQD--WQR-----------RYC-EA-L-----RAM-----------------G--KE-----------------V-RVLEY--PE-------------A------------------------------------IHA--FYVF---PEFAESRDLMLRIKE------------------------------------------ 413
414 --------------------------DFVVDQSRDLWFRLYTP-------HVSGDK---------------IP-V-VVF----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFA-----F---------L--SPNAYP-YDNVCRR---FARKLP-AYV-IS------V-N---YR-LA----PE-----------------------------------HRY---PAQYDD--GFDA----------------------------------------------L-----------------------------K--YIE-----------ENHGS-I----------------LP------A-N---A-------DLS--------------------------------------------------------R----C-FF--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAH---------------------------------------------------------------------------------------------N--VAI----RICRE-PRSSFT-----AV--KLI------GLISI---Q-----PFFG-GE-----------------E--------RTEAEKQLV-G-APL-V-SPD-RTDWCW---------------------KA-M---GL------------------------------------------------------------------------------------NRDHEAVNVGG----PN-AV-------------------------------------------------D--IS------------------------------------------------GL---DYP---------------------------E-------------------------TM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-V-----AGFD---PLKD--WQR-----------SYY-EW-L-----KLC-----------------G--KK-----------------A-TLIEY--PN-------------M------------------------------------FHA--FYIF---PELPEAGQLIMRIKDF----------------------------------------- 414
415 --------------------------------SDHLRVRLFLP-------SAADAGDGS---------QLPLP-L-VVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFV-----F---------H--SAASAH-FDALCRR---LAASIP-AAV-AS------V-D---YR-LA----PE-----------------------------------HKH---PAAYDD--GEAA----------------------------------------------L-----------------------------R--WAM-----------AGAGG-A----------------LP--------T---S-------SSS--------------------------------------------------------P----V-FL--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAH---------------------------------------------------------------------------------------------H--VAA----RLSN-----------------HIS------GLVLL---Q-----PFFG-GE-----------------S--------PTASELRLR-G-APF-G-APE-RLAWLW---------------------RA-FLPPGA------------------------------------------------------------------------------------TRGHEAADVPA----AI-SR-------------------------------------------------A--GA------------------------------------------------RV---PFP---------------------------A-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VC-V-----GGWD---AHQD--RQR-----------AYA-RALR-----DAA-----------------G-AEE-----------------V-RLAEF--PD-------------A------------------------------------GHA--FYVF---EELADSKRVLAEVAEF----------------------------------------- 415
416 ---------------------------------KSTWLRLYLPSSAV---NEGNVSSQK------------LP-I-VVY----Y-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFI-----L---------C--SVDMQL-FHDFCSE---VARDLN-AIV-VS------P-S---YR-LA----PE-----------------------------------HRL---PAAYDD--GVEA----------------------------------------------L-----------------------------D--WIKTS----------D---------------------DE---W-IKSH---A-------DFS--------------------------------------------------------N----V-FL--M-G--TS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAY---------------------------------------------------------------------------------------------N--VGL----RSVDS-----VSDLSP----LQIR------GLILH---H-----PFFG-GE-----------------E--------RSESEIRLMNDQ----VCPPI-VTDVMW---------------------DL-SLPVGV------------------------------------------------------------------------------------DR--DHEYSNP----TVGDG-------------------------------------------------S--EKL-----------------------------------------------EKIGRLRW---------------------------K-------------------------VM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MI-G-----GEDD---PMID--LQK-----------DVA-KL-M-----KKK-----------------G---------------------V-EVVEH--YT-------------G------------------------------------GH---VHGAEI-RDPSKRKTLFLSIKNFI---------------------------------------- 416
417 ---------------------------------NDLRVRIYKPAADM---AMAEEKKQK------------LP-V-LVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFC-----I---------G--SCTWAN-THSFCLR---LAADAG-AVV-LS------A-G---YR-LA----PE-----------------------------------HRL---PAALHD--AAGV----------------------------------------------L-----------------------------A--WLSAQ-QQQQS--AGDEDG------------------DT---WCLAEV---A-------DFR--------------------------------------------------------R----V-FV--T-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-LAH---------------------------------------------------------------------------------------------H--LAV----SFGSGEKEKAALVSND---V-TVK------GYVLL---M-----PFFG-GE-----------------K--------RTASEEAESPTTFPPPLMSLD-TLDRYW---------------------RL-ALPAGA------------------------------------------------------------------------------------TR--DHPLANP----FGAN------------------------------------------------------SP-----------------------------------------------GLEAVELP---------------------------P-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AV-A-----AGQD---MLRD--RVV-----------DYV-ER-L-----KAM-------------------GK-----P------------V-ELVEF--AA-------------E------------------------------------PHG--FFTLD----------------------------------------------------------- 417
418 --------------------------------------RIYKPTM-A---AHAEKQKQK------------LP-V-LVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFC-----L---------G--CCTWAN-THSFCLR---LAAGAG-ALV-LS------A-C---YR-LA----PE-----------------------------------HPL---PAALYD--AAAL----------------------------------------------L-----------------------------T--WLSAQ-QLHSSAAAGDDNA------------------DT---WSLAEV---A-------DFG--------------------------------------------------------R----V-FV--T-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-LAH---------------------------------------------------------------------------------------------H--LAV----SSGPG--GKAALVVRDDVTV-NVK------GYVLL---M-----PFFG-GE-----------------R--------RLPSEEAESTR-----LMNRD-TLDRFW---------------------RL-ALPAGA------------------------------------------------------------------------------------TR--DHPLANP----FGPD------------------------------------------------------SP-----------------------------------------------GLEPVALP---------------------------P-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-A-----AGQD---MLRD--RVV-----------DYG-ER-L-----KAM-------------------GK-----P------------V-KLVEF--AG-------------E------------------------------------PHG--FFTLD----------------------------------------------------------- 418
419 ------------------------------DAGRGLGLRMYKP-------A---AAEKK------------LP-V-LVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFC-----I---------G--SYAWPN-FHAGCLR---LAASLP-AVV-LS------F-D---YR-LA----PE-----------------------------------HRI---PAAHED--AAAA----------------------------------------------L-----------------------------L--WLRSQ--------LASDTS------------------NP---W-LADA---A-------DPR--------------------------------------------------------R----V-FV--S-G--ES-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAH---------------------------------------------------------------------------------------------H--LAL----RFGAS----G--LD----PVAHIA------GYILL---M-----PAFM-SE-----------------Q--------PTRSELD-SPATA---FLTRD-MCDRYG---------------------RL-SFPAGA------------------------------------------------------------------------------------NR--DHPLLNP----LGPE------------------------------------------------------SP-----------------------------------------------SLDPLLDV---------------------------A-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-A-----AEGD---LLRD--KNV-----------EYA-ER-L-----KAL-------------AAEKGKGK---EEN------------V-ELVVF--QG-------------E------------------------------------EHA--FFGVK--PMSEAAGELVRVIGR------------------------------------------ 419
420 ------------------------------DAGRGLGLRMYKP-------A---AAEKK------------LP-V-LVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFC-----V---------G--SYAWPN-FHAGCLR---LAAELP-AVV-LS------F-D---YR-LA----PE-----------------------------------HRF---PAAHDD--AATA----------------------------------------------L-----------------------------L--WLRDQ--------LASGTT------------------NP---W-LADA---A-------DAR--------------------------------------------------------R----V-FV--S-G--ES-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LTH---------------------------------------------------------------------------------------------H--LAL----RFGST----PGLLD----PI-NIA------GYVML---M-----PGFL-SE-----------------R--------RTRSELE-SPATA---FLTRD-MCDTLS---------------------RL-FLPAGA------------------------------------------------------------------------------------DK--DHPLINP----LGPE------------------------------------------------------SP-----------------------------------------------SLDPLLDV---------------------------P-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-A-----AERD---LLRD--KNV-----------EYA-ER-L-----RAL-------------AA-AGKGKKKEEEN------------V-ELVVF--PG-------------E------------------------------------EHA--FFGVK--PESEAAGEVV----------------------------------------------- 420
421 -----------------------------------------------------------------------LP-V-FFY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFC-----I---------G--SRTWPN-CQNYCLR---LAAELD-AVV-VA------P-D---YR-LA----PE-----------------------------------HRL---PAALDD--AAAA----------------------------------------------L-----------------------------L--WLASH--------AAPGGG------------------DP---W-LTEA---A-------DFG--------------------------------------------------------R----I-FV--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-IAH---------------------------------------------------------------------------------------------H--LAV----RFGCP----TARTSLGP-GV-RVK------GYVQL---M-----PFFG-GT-----------------E--------RTRSEAE-CPDDA---FLNRP-LNDRYW---------------------RL-SLPDGA------------------------------------------------------------------------------------TA--DHPASNP----FAPG--------------------------------------------------E--SRE-----------------------------------------------ALEAAEMA---------------------------P-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-V-----GGRD---ILRD--RAV-----------DYA-AR-L-----RAM-------------------GK-----P------------V-EVREF--EG-------------Q------------------------------------QHG--FFTID----------------------------------------------------------- 421
422 --------------------------------------RVYRPSS-P---VAAEKEEKK------------LP-V-LVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GYC-----L---------G--SYAQPS-FHVFCLR---AAAELP-AVV-LS------V-Q---YR-LA----PE-----------------------------------HRL---PAAIHD--GEGF----------------------------------------------L-----------------------------S--WLRAQ-AE-----TRNA--------------------DP---W-LADS---A-------DFA--------------------------------------------------------R----T-FV--S-G--CS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAH---------------------------------------------------------------------------------------------H--VTV----QAAAS----SGIIDSSPVPF-RIA------GFVLL---S-----AFFS-GV-----------------Q--------RTPAEIDLSPADV---SLTAD-MADQLW---------------------RM-ALPAGA------------------------------------------------------------------------------------TR--DHPLANP----FGPET-------------------------------------------------E--SSG-----------------------------------------------FIAAVELP---------------------------P-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-A-----PGID---VLRD--RVL-----------GYA-AA-M-----REL-------------------GK-----D------------V-ELARF--EG-------------E------------------------------------QHG--FSVSR--PFSDAADEMMRLLRR------------------------------------------ 422
423 --------------------------------------RVYRPS----------EKKTK------------LP-V-LVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GYC-----I---------G--SYAQPP-FHAFCLR---AAAELP-ALV-LS------V-Q---YR-LA----PE-----------------------------------HRL---PAAVHD--GADF----------------------------------------------L-----------------------------S--WLRAQ-AE-----TGGAAE------------------DT---W-LAES---A-------DFA--------------------------------------------------------R----T-FV--S-G--VS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAH---------------------------------------------------------------------------------------------H--VTV----QNAAT----S----ASPARL-RIA------GLVLL---S-----AFFG-GV-----------------R--------RTPAETALSPADV---SLTVD-VADQLW---------------------RL-ALPAGA------------------------------------------------------------------------------------TR--DHPLASP----EIPE----------------------------------------------------------------------------------------------------------AVELP---------------------------P-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-A-----PGRD---VLRD--RVL-----------GYA-AR-L-----GEM-------------------GK-----A------------V-EVVRF--DD-------------E------------------------------------QHG--FSVLR--PFGVAADELMRVLRR------------------------------------------ 423
424 --------------------------------------RMYRPHNNK---P---DNKQQ------------LP-V-LVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFV-----F---------G--SYSWPK-NHAGCLR---LAAELP-AIV-LS------F-D---YR-LA----PE-----------------------------------HRL---PAAMDD--AASA----------------------------------------------L-----------------------------H--WVAAR--------ISSGSA------------------DP---W-L--P---A-------ETT--------------------------------------------------------Q----I-FL--G-G--QS-----------------SG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-LAH---------------------------------------------------------------------------------------------H--LLL----------------LDKKKIKI-KIA------GYILL---M-----PPFL-SE-----------------K--------VTQSELD-APDAA---FLSRA-ASDRYF---------------------RL-MMPAGA------------------------------------------------------------------------------------DK--DHPLVNP----FGAG------------------------------------------------------SP-----------------------------------------------SLDTAHVG---------------------------R-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-A-----AECD---MVRD--KDV-----------EYA-ER-L-----RAM-------------------GK-----D------------V-ELAVF--AG-------------Q------------------------------------EHA--F--------------------------------------------------------------- 424
425 ------------------------------------WARLYAP-------A---ESGNK------------VP-V-VVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFC-----V---------G--SAAWSC-YHEFLAQ---LPIKSG-CAV-MS------V-D---YR-LA----PE-----------------------------------HRL---PAAFDD--GLAA----------------------------------------------V-----------------------------R--WLRQQ-AASC---RNNDDL------------------SW---W--RGR---C-------RFD--------------------------------------------------------S----V-FL--M-G--DS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-IAF---------------------------------------------------------------------------------------------H--VAA----RLGQGHLGASLG------PL-CVR------GAILV---Q-----PFFG-GE-----------------A--------RTASEKTMAQPPRS--ALSLS-TSDSYW---------------------RM-ALPAGA------------------------------------------------------------------------------------GR--DHPWCNP---LSSSSS-------------------------------------------------R--GAP-----------------------------------------------RLDTLPLP---------------------------P-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VC-I-----AEAD---ILRD--RNL-----------ELC-KA-L-----RKA-------------------GK-----S------------V-EQAMY--GG-------------V------------------------------------GHA--FQVLH--NYHLSQPRTQEML-------------------------------------------- 425
426 ------------------------------KLSNDTWTRVYIPDAAA---A---SPSVT------------LP-L-LVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFC-----V---------G--SAAWSC-YHDFLTS---LAVKAR-CVI-VS------V-N---YR-LA----PE-----------------------------------HRL---PAAYDD--GVNV----------------------------------------------V-----------------------------S--WLVKQ-QIS-----TGGGY------------------PS---W--LSK---C-------NLS--------------------------------------------------------N----V-FL--A-G--DS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAY---------------------------------------------------------------------------------------------Q--VAV----RIMAS--GKYAN------TL-HLK------GIILI---H-----PFFG-GE-----------------S--------RTSSEKQQHHTKSS--ALTLS-ASDAYW---------------------RL-ALPRGA------------------------------------------------------------------------------------SR--DHPWCNP---LMSSA-----------------------------------------------------GA-----------------------------------------------------KLP---------------------------T-------------------------TM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VF-M-----AEFD---ILKE--RNL-----------EMC-KV-M-----RSH-------------------GK-----R------------V-EGIVH--GG-------------V------------------------------------GHA--FHILD--NSSVSRDRIHDMMCR------------------------------------------ 426
427 -----------------------------DKLTNV-WARLYVPMTTT---K---SSVSK------------LP-L-IVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFC-----V---------G--SASWLC-YHEFLAR---LSARSR-CLV-MS------V-N---YR-LA----PE-----------------------------------NPL---PAAYED--GVNA----------------------------------------------I-----------------------------L--WLNKA---------RNDNL-----------------------W--AKQ---C-------DFG--------------------------------------------------------R----I-FL--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAQ---------------------------------------------------------------------------------------------Q--VAA----RLASPEDLA----------L-KIE------GTILI---Q-----PFYS-GE-----------------E--------RTESERRVGNDKTA--VLTLA-SSDAWW---------------------RM-SLPRGA------------------------------------------------------------------------------------NR--EHPYCKPVKMIIKSS------------------------------------------------------------------------------------------------------------TVT---------------------------R-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VC-V-----AEMD---LLMD--SNM-----------EMC-DG-N-----EDV-------------------IK-----R------------V----LH--KG-------------V------------------------------------GHA--FHILG--KSQLAHTTTLEMLCQ------------------------------------------ 427
428 -----------------------------------LWARVFLPPG-----ADHG--NNK------------LP-V-VVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------AYV-----I---------G--SAADPM-THGYLNG---LVAAAN-VLA-VA------L-E---YR-LA----PE-----------------------------------HAL---PAAYDD--AWEG----------------------------------------------L-----------------------------K--WVA-----------S-------------HATASGTSQEP---W-LLDH---G-------DFS--------------------------------------------------------R----V-FL--A-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-IAH---------------------------------------------------------------------------------------------V--MAV----RAGEQ------QGGLGLGI--GIK------GVLIV---H-----PYFS-GV-----------------A--------DIGKEATTGKE-------EKA-KADAFW----------------------K-FLYPDA------------------------------------------------------------------------------------PLGLDDPLSNP----FS-E--------------------------------------------------A--AGG-----------------------------------------------SAARIAGE---------------------------R-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VC-V-----AEKD---GLRD--RGV-----------WYY-ES-L-----KAS-----------------G-YGG-Q---------------V-ELLES--MG-------------E------------------------------------GHV--FYCMN--PRSEKTVEMQER--------------------------------------------- 428
429 --------------------------------------RVYLPP-------DAA--AAK------------LP-V-VVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFV-----V---------G--SPARPS-THAYLND---LVARSG-AIG-VS------V-Y---YG-LA----PE-----------------------------------RAL---PAAYED--GWAA----------------------------------------------V-----------------------------Q--WAA-----------S-------------GA-------DP---W-LLDH---A-------DLS--------------------------------------------------------R----V-FL--S-G--CS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAH---------------------------------------------------------------------------------------------N--MAV----RAG-S------AGALPDGV--KIR------GLMVV---H-----PYFT-GK-----------------E--------PVGAEAALGPD-------VRE-FMDRTW----------------------R-FVFPGT------------------------------------------------------------------------------------S-GLDDPRVNP----FV-DC-------------------------------------------------A--ARA-----------------------------------------------ASAAIPCE---------------------------R-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VC-V-----AETDY--LLKE--RAL-----------WYA-KE-L-----KAS-----------------G-YGG-E---------------V-EVFES--KG-------------V------------------------------------GHA--FQFDK--LDSEEGVKL------------------------------------------------ 429
430 ------------------------------------SVRLYLPPA-----ATNAPECKQ------------LP-V-VFY----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFV-----A---------E--SVGSPP-GHRFLNS---LAAACP-AIA-VS------V-E---YR-LA----PE-----------------------------------HPL---PAAYDD--CLSA----------------------------------------------L-----------------------------R--WVL-----------S-------------AA-------DP---W-VAAH---G-------DLA--------------------------------------------------------R----V-FL--A-G--DS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-ACH---------------------------------------------------------------------------------------------H--LAL----HAQ------------PGV---KLK------GAVLI---H-----PWFW-GS-----------------E--------AV-GEESRHPV-------ARA-MGGRLW----------------------T-FACPGT------------------------------------------------------------------------------------S-GVDDPRMNP----MA-PG-------------------------------------------------A--PGL-----------------------------------------------ET--LACE---------------------------R-------------------------VM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VC-V-----AEGD---FLRW--RGR-----------AYA-EA-V-----TSA-----------------R-GGG-EQHG------------V-ELLET--EG-------------E------------------------------------GHV--FHLFK--PDCDKAKDMFHR--------------------------------------------- 430
431 ------------------------------------SARLYLPPA-----AATA--STK------------LP-V-IVY----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFV-----A---------E--SAKSPN-YHRFLND---LASACP-AIG-VS------V-D---YR-LA----PE-----------------------------------HPL---PAAYED--CLAA----------------------------------------------L-----------------------------R--WTF-----------SP------------TA-------DP---W-ISAH---A-------DLA--------------------------------------------------------R----V-FV--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-ICH---------------------------------------------------------------------------------------------H--IAV------Q------------PDVA--RLR------GTVLI---H-----PWFW-GS-----------------E--------AV-GEETRDPA-------ERA-MGCGLW----------------------K-FACPGS------------------------------------------------------------------------------------A-GPDDPRMNP----MA-PG-------------------------------------------------A--PGL-----------------------------------------------DT--LACE---------------------------R-------------------------VM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VC-T-----AEGD---FLRW--RGR-----------AYA-EA-V-----TAA-----------------R-GGG-EGQG------------I-ELLET--DG-------------E------------------------------------GHV--FYLFK--PDCEKAKEMIDR--------------------------------------------- 431
432 --------------------------------------RLYLPPC-----AGATAGGKK------------LP-I-LVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GYV-----I---------G--SAASGA-YHRCLND---LAAACP-AVA-VS------V-D---YR-LA----PE-----------------------------------HPL---PAAYDD--SVAA----------------------------------------------L-----------------------------T--WVL-----------S-------------AA-------DP---W-LADH---G-------DPA--------------------------------------------------------R----L-FL--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-ICH---------------------------------------------------------------------------------------------H--LAM----HRD------------FTSK--LIK------GIVLI---H-----PWFW-GK-----------------E--------PIAGEEARQRD-------EK-----GLW----------------------E-FVCPGA------------------------------------------------------------------------------------ADGADDPRMNP----TA-PG-------------------------------------------------A--PGL-----------------------------------------------ET--LACE---------------------------K-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VC-V-----AEGD---FLRW--RGR-----------AYA-EA--------AA-----------------R-ARG-PDRA------------V-ELFES--EG-------------V------------------------------------GHV--FYLYE--PAAEKAAELLGKIA------------------------------------------- 432
433 ----------------------------------NVSARLYLPR------SDGDTPAGK------------LP-V-LVY----Y-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFC-----L---------G--SAFDRT-YHDYFNN---FVALAK-TVV-IS------V-E---YR-LA----PE-----------------------------------HPI---PAAYAD--SWEA----------------------------------------------L-----------------------------A--WVV-----------SHIAGSTGN--------------ES---W-LTGH---A-------DFS--------------------------------------------------------R----L-YL--G-G--ES-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAH---------------------------------------------------------------------------------------------H--MMM----RVGAE--------GLAHNA--NIC------GLVLI---H-----PYFL-GS-----------------N--------KVNSDDL-DLA-------ARD-RLGKLW----------------------H-AVCPMT------------------------------------------------------------------------------------I-GEDDPLINP----FV-DS-------------------------------------------------A--PSL-----------------------------------------------EA--LACI---------------------------H-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VC-V-----AEAD---VLRD--RGN-----------TYY-DL-L-----KGS-----------------G-WHG-E---------------V-KIWQA--PG-------------K------------------------------------GHRFHFHLLE--PGCDEAV-------------------------------------------------- 433
434 -----------------------------------VSARLYLPR------LDADAPAAK------------LP-V-LVY----Y-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFC-----L---------G--SAFNPT-FHAYFNS---FAALAN-VVV-VS------V-E---YR-LA----PE-----------------------------------HPV---PAAYAD--SWEA----------------------------------------------L-----------------------------A--WVV-----------SHAAGSAGD--------------EP---W-LSDH---A-------DFS--------------------------------------------------------R----L-YL--G-G--ES-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAH---------------------------------------------------------------------------------------------H--MAM----RVGAE--------GLAHDT--KIR------GLVMI---H-----PYFL-GS-----------------N--------KVDSDDL-DPA-------TRE-SLGSLW----------------------S-VMCPTT------------------------------------------------------------------------------------T-GEDDPLINP----FV-EG-------------------------------------------------A--PDL-----------------------------------------------EA--LACG---------------------------R-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VC-V-----ALGD---VLRD--RGR-----------NYY-DR-L-----RAS-----------------G-WRG-E---------------A-EIWQV--PG-------------K------------------------------------GHT--FHLLE--PCCDEAV-------------------------------------------------- 434
435 -----------------------------------VSARIYLPA------APAGGHQSK------------VP-V-LLF----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFC-----L---------G--SAFDEA-VHGHANQ---LSAQAS-VIV-VS------V-E---YR-LA----PE-----------------------------------HPV---PALYED--AWAA----------------------------------------------L-----------------------------Q--WVA-----------AHAAGQ-GP--------------EP---W-LTAH---A-------DFG--------------------------------------------------------R----V-HV--G-G--ES-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAH---------------------------------------------------------------------------------------------H--TAM----RAGVE--------ELGHGV--KVN------SLVLI---H-----PYFL-GG-----------------D--------SSESDEM-GMA-------LLR-ELVRLW----------------------P-VVCPGT------------------------------------------------------------------------------------S-GCDDPWINP----MS-DG-------------------------------------------------A--PSL-----------------------------------------------AG--LGCA---------------------------R-------------------------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VC-V-----GGKD---AMRG--RGR-----------LYC-EK-L-----MGS-----------------G-WHG-E---------------V-EVWEA--DG-------------Q------------------------------------GHG--FHLFC--P-------------------------------------------------------- 435
436 -----------------------------------LAVRLYRPPP-----SHGDN---K------------LP-V-LLY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------AFV-----V---------E--SAFDPV-YHGYLNA---VAAKAG-VIA-VS------V-N---YR-LA----PE-----------------------------------HPL---PAAYED--SWTA----------------------------------------------L-----------------------------K--WVL-----------GHVSSGSGSGGGSS--------------W-LAKH---G-------DVS--------------------------------------------------------R----L-FI--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAH---------------------------------------------------------------------------------------------N--LAI----RAGKQQQQQQGGLGLGRVA--MIK------GLALL---D-----PYFL-GP-----------------H--------A-------DP------------GAERAW----------------------G-FIC-AG------------------------------------------------------------------------------------RYGTEHPYVNP----MASLP-------------------------------------------------A--EAW-----------------------------------------------RR-GLGGA---------------------------R-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MT-V-----SGQD---RLGP--WQR-----------AYV-DA-L-----RAS-----------------G-WGG-D---------------A-QLYET--PG-------------E------------------------------------GHC--YFLNN--LESPKA--------------------------------------------------- 436
437 ---------------------------------SDVRARIYL-PS-----FRAST---K------------VP-V-VVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------AFV-----V---------E--SAFNPI-YHAYLNT---LAAKAG-VVA-VS------V-N---YR-LA----PE-----------------------------------HPL---PAAYDD--SWAA----------------------------------------------L-----------------------------K--WVL-----------AH---GNGNNGTDADT-------DQ---W-LSQY---G-------DMS--------------------------------------------------------R----L-FL--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAH---------------------------------------------------------------------------------------------N--LAL----RAGEE------GLGDGADA--KIK------GVALL---D-----PYFQ-GR-----------------S--------AVGADSM-DPA-------YLQ-SAARTW----------------------S-FIC-AG------------------------------------------------------------------------------------KYPIDHPYANP----LA-LP-------------------------------------------------A--SSW-----------------------------------------------QH--LGCS---------------------------R-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-V-----SGQD---RLSP--WQR-----------AYY-ST-L-----RSS-----------------G-WPG-Q---------------A-ELYET--PG-------------E------------------------------------GHV--YFLTK----------------------------------------------------------- 437
438 -----------------------------------LAARLYLP--------RGGG---KEEDPV---SGALLP-V-LVF----Y-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------AFV-----I---------E--SAFTPK-YHVYLNS---LVAKAG-VVA-VS------V-E---YR-LA----PE-----------------------------------HPL---PAAYED--SWRA----------------------------------------------L-----------------------------N--WVA-----------KNADAG---------P-------EP---W-LRDR---G-------NLS--------------------------------------------------------R----L-FV--A-G--DS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAH---------------------------------------------------------------------------------------------N--MAM----RAGNE-----GGLAGG--A--AIT------GILLL---D-----PYFW-GK-----------------K--------PVGAETT-DQA-------KRR-QYEATW----------------------S-FIC-DG------------------------------------------------------------------------------------KYGIDDPLIDP----LA-TP-------------------------------------------------A--SEL-----------------------------------------------RK--MACA---------------------------R-------------------------VA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-V-----SGLD---DFEE--RGK-----------AYA-AA-L-----RDS-----------------G-WDG-E---------------V-VQYET--AG-------------E------------------------------------RHV--YFLDA--PK------------------------------------------------------- 438
439 --------------------------------------RLYLPKD-----VPRSA---K------------VP-I-LVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------AFA-----V---------H--SAFSAAPHHRFLNS---LVAAAG-VVA-VS------V-D---YR-LA----PE-----------------------------------HPL---PAAYDD--AWAA----------------------------------------------L-----------------------------A--WTL-----------TS---G-------LRK-------EP---W-LAEH---G-------DAA--------------------------------------------------------R----V-FV--A-G--DS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAQ---------------------------------------------------------------------------------------------N--VAM----RAGGWNTTGGKLLPIPGSA--RIE------GLVLL---H-----PYFR-GK-----------------D--------PLPSESRNNPG-------FLQ-RAERSW----------------------G-FVC-SW------------------------------------------------------------------------------------RYGIDHPFINP----LA-MP-------------------------------------------------A--EEW-----------------------------------------------AA--LGCR---------------------------R-------------------------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-A-----AGLD---TMRD--RAR-----------RYV-ET-L-----RGS-----------------GEWAGEE---------------A-ALYET--DG-------------E------------------------------------GHV--YFLENSGPGADKAQK------------------------------------------------- 439
440 -----------------------------------LAVRIYLPTL-----SRSNGTAKK------------LP-L-VVF----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFV-----T---------E--SAFSPT-YQRYLNA---LAAKAG-ALV-VS------V-D---YH-LS----PE-----------------------------------HRL---PTGYDD--AWAA----------------------------------------------L-----------------------------Q--WAL-----------TSARSG-------SEA-------EP---W-LHRH---A-------DLA--------------------------------------------------------R----L-FL--I-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAH---------------------------------------------------------------------------------------------N--MAM----RAGRE----GGGLPGG--A--TIE------GIALL---D-----PYFW-GK-----------------R--------PVPSETR-DAE-------LRR-WRERTW----------------------S-FVC-GG------------------------------------------------------------------------------------KFGADDPVINP----VA-ME-------------------------------------------------S--EEW-----------------------------------------------RR-HLACA---------------------------R-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-V-----AGLD---MLAP--RGR-----------AYV-QA-L-----RAS-----------------G-WGG-D---------------V-RLYET--PG-------------E------------------------------------THV--YFLLK--PNGEKA--------------------------------------------------- 440
441 -----------------------------------LAVRIYLPAQ-----AKANGTA-K------------LP-L-VVF----Y-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFV-----T---------E--SAFSPM-YQRYLNA---LASKAG-VLV-VS------V-D---YH-LS----PE-----------------------------------HRL---PAGYDD--AWAA----------------------------------------------L-----------------------------Q--WAL-----------RSARSG--------LA-------EP---W-LHRH---A-------DLT--------------------------------------------------------R----L-FL--I-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAH---------------------------------------------------------------------------------------------N--MAM----RADRE-----GGLPGG--A--TIE------GIALL---D-----PYFW-GK-----------------R--------PVPSETR-DPE-------ERR-MKEQSW----------------------S-FIC-AG------------------------------------------------------------------------------------KYGADDPVINP----VA-MA-------------------------------------------------G--EEW-----------------------------------------------RR-HLTCA---------------------------R-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-V-----AGLD---VLSA--RGR-----------AYV-RA-L-----RAS-----------------G-WAG-E---------------V-ELYET--PG-------------E------------------------------------NHV--YFLLK--PD------------------------------------------------------- 441
442 -----------------------------------VAARLYLPDIQAAAGRSDGTAITK------------LP-I-VVF----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------YFI-----V---------G--SAGSPR-YHRYVNS---LAARAR-AIA-VS------V-D---YR-LA----PE-----------------------------------HPL---PAAYDD--SWLT----------------------------------------------L-----------------------------N--WAA-----------SG------------SA-------DP---W-LSEH---G-------DLG--------------------------------------------------------R----V-FL--A-G--LS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAH---------------------------------------------------------------------------------------------N--MAI----DAGLT------GLRAPAR----IE------GAILL---H-----PSFC-GE-----------------Q--------RMEAE---AEE-------HWA-SVKKRW----------------------A-VICPGA------------------------------------------------------------------------------------RGGLDDPRMNP----TA-AG-------------------------------------------------A--PSL-----------------------------------------------AA--LACE---------------------------R-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-A-----ASED---PRMP--RDR-----------AYY-EA-V-----VSS-----------------G-WGG-S---------------V-EWFVS--EG-------------E------------------------------------GHG--FFIDE--PGGSEAAALMERVVG------------------------------------------ 442
443 -------------------------------ADTGVSVRLYLPMLKEPA------ASTK------------LP-V-LVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------AFL-----I---------G--SAGDAT-YHSYVNA---LAAAAG-VLV-VS------A-D---YR-LA----PE-----------------------------------HPL---PAAYDD--SWAA----------------------------------------------L-----------------------------Q--WAA-----------VS------------AQ-------DD---W-ITQY---G-------DTS--------------------------------------------------------R----L-FL--A-G--DS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IVH---------------------------------------------------------------------------------------------D--MLM----RAASD------NDGGEPR----IE------GAILL---H-----PWFS-GS-----------------T--------AIEGE---PPA-------AAM-ITGMLW----------------------S-YACPGA------------------------------------------------------------------------------------VGGADDPRMNP----LA-PG-------------------------------------------------A--PAL-----------------------------------------------EK--LGCV---------------------------R-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-A-----GLKD---GLAA--RDR-----------AYY-DA-L-----VAS-----------------G-WRG-D---------------A-AWLES--EG-------------E------------------------------------GHV--FFLEK--PGCENAKQLMDR--------------------------------------------- 443
444 --------------------------------------RLYIPDI-----CGSGSQSSK------------LP-I-LLY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GLV-----L---------D--SAASPA-YHRYLNS---VVSKAG-VLA-MS------V-N---YR-LA----PE-----------------------------------HPV---PAAYDD--SWMA----------------------------------------------L-----------------------------G--WAA------------S------------RE-------DP---W-LSEH---G-------DAG--------------------------------------------------------R----I-FL--A-G--DS-----------------GG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IVH---------------------------------------------------------------------------------------------N--IAI----MACTR------EYGLPPGT--VLE------GAIIL---H-----PMFG-GK-----------------E--------PVEGE---ATE-------GRE-FGEKLW---------------------LL-IICPEG------------------------------------------------------------------------------------TEGADDPRLNP----MA-HG-------------------------------------------------A--PSL-----------------------------------------------QK--LACR---------------------------K-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VC-S-----AERD---FARP--RAA-----------AYY-QA-V-----KAS-----------------A-WRG-S---------------V-EWLES--KG-------------E------------------------------------EHV--FFLNK--PESGESLALMDR--------------------------------------------- 444
445 ---------------------------------NNLSLRIYLPEKAA---TAETEASVK------------LP-L-LVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFL-----V---------E--TAFSPT-YHTFLTA---AVSASD-CVA-VS------V-D---YR-RA----PE-----------------------------------HPI---PTSYDD--SWTA----------------------------------------------L-----------------------------K--WVF-----------SHIAG------------------SGSEDW-LNKH---A-------DFS--------------------------------------------------------K----V-FL--A-G--DS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-ITH---------------------------------------------------------------------------------------------H--MTM----KAAKD----KLSPESLNES--GIS------GIILV---H-----PYFW-SK-----------------T--------PVDDKETTDVA-------IRT-WIESVW----------------------T-LASPNS------------------------------------------------------------------------------------KDGSDDPFINV----VQ-SE-------------------------------------------------S--VDL-----------------------------------------------SG--LGCG---------------------------K-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VM-V-----AEKD---ALVR--QGW-----------GYW-EK-L-----GKS-----------------R-WNG-E---------------VLDVVET--KG-------------E------------------------------------GHV--FHLRD--PNSEKAHELVHRFAG------------------------------------------ 445
446 ------------------------------SADNNLSVRIYLPEKAA----AETDS--K------------LP-L-LVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFI-----I---------E--TAFSPT-YHTFLTT---SVSASN-CVA-VS------V-D---YR-RA----PE-----------------------------------HPI---SVPFDD--SWTA----------------------------------------------L-----------------------------K--WVF-----------THITG------------------SGQEDW-LNKH---A-------DFS--------------------------------------------------------R----V-FL--S-G--DS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IVH---------------------------------------------------------------------------------------------H--MAM----RAAKE----KLSP-GLNDT--GIS------GIILL---H-----PYFW-SK-----------------T--------PIDEKDTKDET-------LRM-KIEAFW----------------------M-MASPNS------------------------------------------------------------------------------------KDGTDDPLLNV----VQ-SE-------------------------------------------------S--VDL-----------------------------------------------SG--LGCG---------------------------K-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VM-V-----AEKD---ALVR--QGW-----------GYA-AK-L-----EKS-----------------G-WKG-E---------------V-EVVES--EG-------------E------------------------------------DHV--FHLLK--PECDNAIEVMHKFSG------------------------------------------ 446
447 -------------------------------PEKNLSLRIYLPEKVT---VK------K------------LP-I-LIY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFI-----I---------E--TAFSPP-YHTFLTS---AVAAAN-CLA-IS------V-N---YR-RA----PE-----------------------------------FPV---PIPYED--SWDS----------------------------------------------L-----------------------------K--WVL-----------THITG------------------TGPETW-INKH---G-------DFG--------------------------------------------------------K----V-FL--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-ISH---------------------------------------------------------------------------------------------H--LTM----RAKKE----KLC-----DS--LIS------GIILI---H-----PYFW-SK-----------------T--------PIDEFEVRDVG-------KTK-GVEGSW----------------------R-VASPNS------------------------------------------------------------------------------------KQGVDDPWLNV----VG-S------------------------------------------------------DP-----------------------------------------------SG--LGCG---------------------------R-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VM-V-----AGDD---LFVR--QGW-----------CYA-EK-L-----KKS-----------------G-WEG-E---------------V-EVMET--KN-------------E------------------------------------GHV--F--------------------------------------------------------------- 447
448 -------------------------------PEKNLSLRIYLPQNSV---YETGEK--K------------IP-L-LVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFI-----M---------E--TAFSPI-YHTFLTS---AVSATD-CIA-VS------V-E---YR-RA----PE-----------------------------------HPI---PTLYED--SWDA----------------------------------------------I-----------------------------Q--WIF-----------THITR------------------SGPEDW-LNKH---A-------DFS--------------------------------------------------------K----V-FL--A-G--DS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAH---------------------------------------------------------------------------------------------H--MAI----RVDKE----KLPPENFK-----IS------GMILF---H-----PYFL-SK-----------------A--------LIEEMEVE----------AMR-YYERLW----------------------R-IASPDS------------------------------------------------------------------------------------GNGVEDPWINV----VG-S------------------------------------------------------DL-----------------------------------------------TG--LGCR---------------------------R-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VM-V-----AGND---VLAR--GGW-----------SYV-AE-L-----EKS-----------------G-WIG-K---------------V-KVMET--KE-------------E------------------------------------GHV--FHLRD----------------------------------------------------------- 448
449 -------------------------------PGHNLSVRLFLPHKST---QLAAGN--K------------LP-L-LIY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------AWI-----N---------E--SPFSPI-YHNFLTE---VVKSAN-CLA-VS------V-Q---YR-RA----PE-----------------------------------DPV---PAAYED--TWSA----------------------------------------------I-----------------------------Q--WIF-----------SHSCG------------------SGEEDW-INKY---A-------DFE--------------------------------------------------------R----V-FL--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-ISH---------------------------------------------------------------------------------------------H--MAM----RAGKE----KLKPR--------IK------GTVIV---H-----PAIW-GK-----------------D--------PVDEHDVQDRE-------IRD-GVAEVW---------------------EK-IVSPNS------------------------------------------------------------------------------------VDGADDPWFNV----VG-SG-------------------------------------------------S---NF-----------------------------------------------SG--MGCD---------------------------K-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VE-V-----AGKD---VFWR--QGL-----------AYA-AK-L-----KKS-----------------G-WKG-E---------------V-EVIEE--ED-------------E------------------------------------EHC--FHLLN----------------------------------------------------------- 449
450 -------------------------------PKTGLSARIYRP--------FSIQPGQK------------IP-L-MLY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------AFL-----I---------S--STSFPS-YHTSLNK---IVNQAN-VIA-VS------V-N---YR-LA----PE-----------------------------------HPL---PTAYED--SWTA----------------------------------------------L-----------------------------K--NIQ-----------AIN--------------------EP---W-INDY---A-------DLD--------------------------------------------------------S----L-FL--V-G--DS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-ISH---------------------------------------------------------------------------------------------H--LAF----RAKQS----------DQTL--KIK------GIGMI---H-----PYFW-GT-----------------Q--------PIGAEIKDEA--------RKQ-MVDGWW----------------------E-FVCPSE------------------------------------------------------------------------------------K-GSDDPWINP----FA-DG-------------------------------------------------S--PDL-----------------------------------------------GG--LGCE---------------------------R-------------------------VM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IT-V-----AEKD---ILNE--RGK-----------MYY-ERLV-----KSE-------------------WKG-K---------------V-EIMET--KE-------------K------------------------------------DHV--F--------------------------------------------------------------- 450
451 -------------------------------AATGVSARLFLP-------SRTTTTSNN---------L--LP-V-VMY----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------SFC-----T---------E--SAFCRT-YHNYARS---LAAN-AGALV-VS------V-E---YR-LA----PE-----------------------------------HPI---PAPYDD--AWAA----------------------------------------------L-----------------------------Q--WVA-----------SFS-D-------------------P---W-LAAH---A-------DPA--------------------------------------------------------R----L-FV--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IVY---------------------------------------------------------------------------------------------N--TAV----RAAAS-MTS--------VV--DIQ------GLVIV---Q-----PYFW-GT-----------------E--------RLPSEELAE-DAGAV-L-PAC-LVDRAW---------------------PY-VTAGQA------------------------------------------------------------------------------------CNDDP--RINP----RD-ED-------------------------------------------------I--ASL-----------------------------------------------A-----CS---------------------------R-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VA-V-----AEKD---MLRE--RGS-----------RLA-AR-L-----RDC-RRP---IGHDDDNDDDD-NYD-----------------V-TLVES--EG-------------E------------------------------------DHG--FHLYS--P-------------------------------------------------------- 451
452 -----------------------------------VSARLFLP-------TRITAPNKV---------ITKLP-V-VVY----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------CFC-----T---------E--SAFCRT-YRNYG-S---LASNVAGALV-VS------V-E---YR-LA----PE-----------------------------------HPV---PAAHDD--AWAV----------------------------------------------L-----------------------------R--WAA-----------SFS-D-------------------P---W-LAHH---A-------DPE--------------------------------------------------------L----V-FV--A-S--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAY---------------------------------------------------------------------------------------------H--TAV----R--AS-QHG--------SM--DVQ------GLVVV---Q-----PYFX-GV-----------------D--------RLPXEVDWG-GAGAV-F-LTW-L-DRVW---------------------PY-VTAGRA------------------------------------------------------------------------------------GNDDP--RIDP----TA-EE-------------------------------------------------I--SSL-----------------------------------------------M-----CK---------------------------R-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VA-V-----AGKD---MLRE--RGQ-----------RLA-DR-I-----CYCWRRPSMMIGGSND--------D-----------------V-ILVES--EG-------------E------------------------------------DHG--FHLYS--PLRATSKKLMESIVHF----------------------------------------- 452
453 ---------------------------------SGVSVRLFLP-------SGAGAAVDSGTGEA---CRTRLP-L-VVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------SFC-----S---------E--SAFSRT-YNRYASS---LASN-AGALV-VS------V-E---YR-LA----PE-----------------------------------FPI---PAAYDD--AWTA----------------------------------------------F-----------------------------Q--WVQMQ-LQQVPSSLSFSAD-------------------P---W-IADY---A-------DPT--------------------------------------------------------R----T-FL--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAY---------------------------------------------------------------------------------------------H--TAV----R-CCH-HHH--------NL--EIE------GLIMV---Q-----PYFW-GS-----------------DG-------RLPSETDDPVPAGSL-FMPAY-GVDRLW---------------------PF-VTNGMA------------------------------------------------------------------------------------GNDDP--RINP----PV-DE-------------------------------------------------I--LSL-----------------------------------------------SL---TCR---------------------------R-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MA-V-----AEKD---TLRD--RGL-----------RLA-ER-M-----APL--------------------TD-----------------M-AVVKS--EG-------------E------------------------------------EHG--FHLYN--P-------------------------------------------------------- 453
454 ----------------------------------RVYIPEATATANVGLP------------------------V-IVQ----L-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFC-----I------------SHPSWVLYHHFYSR---LARALPA-VV-VT------A-E---LP-LA----PE-----------------------------------HRL---PAQIHT--GVDV----------------------------------------------L-----------------------------H---RLRS-IALSSDSSCTPAELL-----------------------LREA---A-------DMS--------------------------------------------------------R----V-FL--V-G--DS-----------------SG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LVH---------------------------------------------------------------------------------------------H--VAA-------------------------RVG--------------EDGPDHWAPLRVV-----------------GGIPIHPGFVRAARSKSELEPRPDSVFFTLDMLDKFL---------------------AM-ALPEGA--------------------------------------------------------------------------------------TKDHPYTCPMGADAPPLE-------------------------------------------------S--VPL------------------------------------------------------P---------------------------P-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VA-V-----GEHD---LIRD--TNL-----------EYC-DA-L-----RDA-----------------GKEV--------------------EVLLS--KG-------------M------------------------------------SH--SFYL------------------------------------------------------------- 454
455 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----DTLCWN---LAQDAG-VPV-IA------V-G---YR-LA----PQ-----------------------------------WRF---PTASDD--ALDA----------------------------------------------W-----------------------------R--WLVEQ-A-------------------------------------EALG---I-------DAQ--------------------------------------------------------R----L-AV--V-G--DS-----------------VG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-LA--------------------------------------------------------------------------------------------------------TILANQLAAQRELP-------APR------LQVMI---Y-----PVTDASC-----------------RR-------P--SVQRYGSGYLL--EAQT---LEWFY---------------------QQ-YATVPA-------------------------------------------------------------------------------------DRLDPRFS-P----LL----------------------------------------------------G--SVA-----------------------------------------------SN----SA---------------------------P-------------------------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ML-I-----AECD---PLHD--QGV-----------AYA-RH-L-----EQA-----------------GVAV--------------------QLAVI--PG-------------V------------------------------------THD--F--------------------------------------------------------------- 455
456 ----------------FTLPQSVCII-----------VRVYKPTICQDNP-----------------------PI-LIY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFV-----T---------G--QLHS---VETTCKK---IACLSK-CIV-VS------V-D---YR-LA----PE-----------------------------------YKY---PTCFYD--GICT----------------------------------------------T-----------------------------K--WVIGN-K-------------------------------------PTIG---G-------NEQ--------------------------------------------------------S----IVGV--C-G--SS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-IA--------------------------------------------------------------------------------------------------------AVVA------LEVP-------SIR------FQILF---Y-----PSTHMNG-----------------EF-------Q--SQREFEKGYFL--EMDT---MRWL----------------------SN-YFYSST-------------------------------------------------------------------------------------DEWDDSFGHP----LL-RD-------------------------------------------------K--SAL-----------------------------------------------SA----SP---------------------------N-------------------------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-I-----AECD---PLRD--EGL-----------AYA-DK-L-----KDA-----------------GGHV--------------------EICVM--EG-------------V------------------------------------IHS--FFTLP----------------------------------------------------------- 456
457 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DTICRI---FSRDAP-CVV-VN------V-E---YR-LA----PE-----------------------------------HRW---PANHED--ATCV----------------------------------------------V-----------------------------R--WVKMN-KS------------------------------------LLGA---T-------NES--------------------------------------------------------T----V-GV--G-G--DS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-LAA---------------------------------------------------------------------------------------------T--VCH----------DLP------------EID------YQVLV---Y-----PSVDLRR-----------------NY-------K--SAE----EFAEM-PGLTKKMVDWFM---------------------DH-Y--------------------IDRSD-------------------------------------------------------------------LDNARASP----LL---------------------------------------------------------------------------------------------------------HTNFNTLP---------------------------P-------------------------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-I-----AELD---ALRD--EGI-----------AYH-EK-L-----KEA-----------------GVKS--------------------QIFTV--KG-------------V------------------------------------THG------------------------------------------------------------------ 457
458 ---------------------------PTKHCSDGIPITVYRSKHCDLCVA--------------------PS-V-FVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GNV-----V---------G--CRQT---VDTICRI---FSRDAP-CVV-VN------V-E---YR-LA----PE-----------------------------------HRW---PANHED--ATCV----------------------------------------------V-----------------------------R--WVKMN-KS------------------------------------LLGA---T-------NES--------------------------------------------------------T----V-GV--G-G--DS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-LAA---------------------------------------------------------------------------------------------T--VCH----------DLP------------EID------YQVLV---Y-----PSVDLRR-----------------NY-------K--SAE----EFAEM-PGLTKKMVDWFT---------------------EK-Y--------------------IDEKD-------------------------------------------------------------------ITNPKASA----IL---------------------------------------------------------------------------------------------------------QKKFSGLP---------------------------P-------------------------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-L-----AELD---QNRD--QGY-----------AYH-EK-L-----KEA-----------------GVKS--------------------QIFTV--KG-------------V------------------------------------THG--FFHLPGHFKECCLRAHEKVSKFI----------------------------------------- 458
459 ---------------------------------GGIPIDVYTPR--EVSAD--------------------PA-I-LVF----Y-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GLV-----V---------G--TRRS---TQLACMH---LAQAAK-CIV-VN------V-E---YR-LA----PE-----------------------------------HKF---PAMIDD--ACCV----------------------------------------------A-----------------------------E--WVKAN-KV------------------------------------LLGG---S-------ERS--------------------------------------------------------R----I-GV--A-G--DS-----------------GG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-IAA---------------------------------------------------------------------------------------------S--VCH----------ECT------------GVN------FQILI---Y-----PHVSARG-----------------DY-------SLPSYQ----EFIDG-PLLDRKLLDWFV---------------------NL-M--------------------AEKTD-------------------------------------------------------------------WANPRLAP----LL---------------------------------------------------------------------------------------------------------REEFSHLP---------------------------P-------------------------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----AEID---PLRD--DSY-----------EYA-KK-L-----SAA-----------------GVHS--------------------ELHLA--KG-------------A------------------------------------LHA--F--------------------------------------------------------------- 459
460 --------------------------------------RIYQPHGCQ--DN--------------------PP-V-WIY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GGC-----V---------G--SRDT---VDTVCRS---ISSQGK-FVV-AN------V-E---YR-LG----PE-----------------------------------HPY---PAYIHD--ATSV----------------------------------------------T-----------------------------K--WIMQN-KV------------------------------------EIGG---G-------EQS--------------------------------------------------------I----V-GV--G-G--DS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-VAT---------------------------------------------------------------------------------------------T--VCH----------EVK------------GLD------YQVLI---F-----PSVDLSF-----------------SY-------P--SHK----ELSTG-YLLESVTCEWFM---------------------DR-LCTTPA------HRFETFGSCIRRED-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSFIGQP---------------------------P-------------------------CF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-I-----TECD---LLRD--EGL-----------AYG-EK-L-----KAA-----------------GVFV--------------------ETLFL--KG-------------T------------------------------------VHA--FFHLPD---------------------------------------------------------- 460
461 ----------------------------------------------------------------------PMSKGLLIH----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FVA-HT------SKSH-----------------EIYL-RS---W--------------A---KD-LG-------------VPIVSI----DYSLAP-----------EQPF---PRAFEE--CFFA----------------------------------------------Y-----------------------------A--WAVKN-------------------------------------------------------APY----------------LGST---------------------------------GEH----I-CL--A-G--DS-----------------SG-----------------------------G-NLCTA---VAMRAASYGIQ-----V------------PDGIVTMYTPFAVHHSASPSRLLCLLDPLLPFGVLMRCLSAYVDLKEER---------------------VFKD------------------------------------------------------APIMRNPYVS-------------------P-LFS------------------------------------------------DE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELLKG----------------------------------------------------------LP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------VH------------------------------------------------------IIGCA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDP--L----------------L----------------DDSISF---------AKK-LRG------------------------MGKP------VFLE----------------------------------IVN--Q-LPHG-----------------------------------------------FLNFST------------- 461
462 ---------------------------------------------------------------------AALSRSLLIH----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FVA-QS------SKSH-----------------EVYL-RS---W--------------A---KE-LD-------------IPIVSL----DYSHAP-----------EQPF---PRAFEE--CFFA----------------------------------------------Y-----------------------------A--WIVRN-------------------------------------------------------APA----------------LGSS---------------------------------GKH----I-CL--V-G--DS-----------------AG-----------------------------G-NLAVA---VAMRAANYGIR-----I------------PDGIVTFYAPFQVRYSPSPSRILSLMDPLLPLGVLSCCLASYAGMKEEPPYA-------------------------------------------------SSPIRK------------------YRNIPIVNNPYIS-------------------P-LVA------------------------------------------------DD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------DLLKG----------------------------------------------------------LP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------MF------------------------------------------------------IVACQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDP--I----------------L----------------DDSITF---------AKM-LKR------------------------IGVP------VKVK----------------------------------VVE--N-LSHG-----------------------------------------------FLNF--------------- 462
463 ---------------------------------------------------------------KARP--APPSPFLVVH----F-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FVA-QT------SKSH-----------------EPYL-KA---W--------------A---QE-LG-------------APVLSI----DYSLAP-----------EAPF---PRALEE----FT----------------------------------------------L-----------------------------C-----------------------------------------------------------------------------------ST---------------------------------AQK----V-CL--A-G--DS-----------------AG-----------------------------G-NLCLT---VSMRAAAFGIQ-----M------------PDGIMAAYPATLMQAAASPSRLLTLLDPLLPLSVLCKCLSAYAGMEPDPPEDPSVEKLGPVNLVCRDTALLFRDLRLGASSLFGSLMNGKGNGARGAG---SETLRKSLSEVGLQSGPPAPF-QDSRKS--------S-------------------P-LLA------------------------------------------------PD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMLKG----------------------------------------------------------LP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------VH------------------------------------------------------IVACA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDP--M----------------L----------------DDSVMF---------ARR-LRG------------------------LGRP------VSLR----------------------------------VVQ--D-LPHG------------------------------------------------------------------ 463
464 --------------------------------------------------SLVKSEGPRSLELRPRPQQAPRSQSLVVH----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FVA-QT------SKSH-----------------EPYL-KS---W--------------A---QE-LG-------------TPILSI----DYSLAP-----------EXPF---PRALEE--CFYA----------------------------------------------Y-----------------------------C--WAVKH-------------------------------------------------------CAL----------------LGST---------------------------------GER----I-CL--A-G--DS-----------------AG-----------------------------G-NLCFT---MSLRAAAFGVR-----V------------PDGIMAAYPATMLQSTASPSRLLSLMDPLLPLSVLTKCVSAYAGGEIEDHSDPNQKALGMMGLVQRDTALLFRDLRLGASSWLHSFLDLSGHKSHTNSVPMAEPMRRSVSEAAL-AQPEGPLGTDSFKSPIVKNPFMS-------------------P-LLA------------------------------------------------PD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------SMLQS----------------------------------------------------------LP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------VH------------------------------------------------------IVACA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDP--M----------------L----------------DDSVMF---------ARR-LRG------------------------LGKP------VTLC----------------------------------VVE--D-LPHG-----------------------------------------------FL----------------- 464
465 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-RQ---W--------------S---KS-LD-------------CPIFSV----DYSLAP-----------EAPF---PEAFEE--CFFA----------------------------------------------Y-----------------------------A--WALNN-------------------------------------------------------AEL----------------LGTT---------------------------------AEN----I-VF--A-G--DS-----------------AG-----------------------------G-NLVLS---VAMRAAQYGIR-----V------------PNTVVAMYPACIVRYSASPARLMSVMDPLLPLGILSGCLGAYSG-------------------------------------------------------------------------------------PLVKNAYIS-------------------P-ALA------------------------------------------------PD-------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELLRG----------------------------------------------------------LP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-------------------------------TD------------------------------------------------------IVGCE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDP--L----------------F----------------DDSVML---------AKR-LQN------------------------IGHD------YQLH----------------------------------VFK--G-LPHG-----------------------------------------------FLNF--------------- 465
466 -------------------------------------TRAYRVPTKYGQVKT--------RIFYP--QP--DRPATLFY----L-------H---------------------------------------------------------G--------------------G-----------------------------------------------------------------------------------------------------GFILGNLDTHDRIMRLLASYSQ--CTVIGID------------YT-LS-----------------------------------------PEA-RFPQAIEEIVAACC-------------------------------------------------------------------------------YFHQQ--------------------------------------------------------------------------------------------------------AEDYQINMSR----I-GF--A-G--DS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-LALASALWLRDKQ--------------IDCGKV---------AG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LWYGLYG--LRDSVTRRLLGGVWDG----LTQQDLQMYEEAYLSNDADRESPYYCLFNNDLTREVPPCFIAG-----AEFDP--LL--DDSRLLYQTLAAHQQPCEFKLY-----------------------------------------------------------------------------------------------------------SGMLHAF---LHYSRMMKTADDALRDGAR------------------------------------------- 466
467 ----------------------------------------------------------------------------LLW----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------AYC-----F--------------GDPLGPAVNLLRVAEIAAARGVSMSIFS------V-E---YT-LA----PA-----------------------------------ATF---PSQQRE--AVAA----------------------------------------------Y-----------------------------L--YLLQN-QGI--------------------------------------------------PAK--------------------------------------------------------K----I-IM--A-G--ES-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HLLLSCLMG-----P--------------PE-------------TG-------------------------------------------------------LAR-------------------------------PKGALLLYPWVNLTNHSPTFESNQHKDVLSKRLL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DRCVESAIGERGRVDALNLENLLKQWKPGTEKSWKE-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PA-YTWVNVGSHDV--LLHDVQ--------------TFVEKA----------------------------------------------------------------RADGARLDLEIADK-------------------------------QPH------------------------------------------------------------------- 467
468 ----------------PPRSYPEDTVVTEDTEMMGVPVRIFRPKEASDDK---------------------LP-G-VIY----Y-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWC-----WDLWEA--------------YDATLRV---VARLDK-MVI-VS------V-R---YR-LA----PE-----------------------------------NPF---PAGPDD--CFVV----------------------------------------------T-----------------------------R--HVLEN-T-------------------------------------ETLG---M-------DPE--------------------------------------------------------N----I-TL--M-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAM---------------------------------------------------------------------------------------------V--MMIKLLSPSKKIDNLS------------KVK------NLVLI---Y-----PALQ-AM-----------------NF-------KLPSYRQHRGSNIP--TILSSELMVKFY---------------------VA-YALGME--------------------------SVDVEELLENSHWSEEMEAKSTCRWIQKE---ADSLRDATESDPKHRNSFLAKKVN---KYFLDPHFSP----LL-AD-------------------------------------------------D--TIL-----------------------------------------------KR----FP---------------------------N-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VL-S-----AEMD---PLRD--DSF-----------LLV-KR-L-----NEL-----------------GVRV--------------------KHRHW--ES-------------M------------------------------------DHG------------------------------------------------------------------ 468
469 ------------------------------------------------DIQTIELEGMTLRIVSPLNAP--TLLPTIIY----Y-------Y---------------------------------------------------------G--------------------G-----------------------------------------------------------------------------------------------------CFVSGGFATHDNQLRQLAYYGQ--CRIIAVQ------------YR-LA-----------------------------------------PEH-TFPAAHDDAQRGAE-------------------------------------------------------------------------------LVRQH--------------------------------------------------------------------------------------------------------AERLGVDKQR----I-TL--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LALVTA--LRLKR--------------AGEWQP---------AQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L---IYP--MLDA-TAHFESYIRNGHDYIITRDTLLSGFEMYLPGIERRHPEASPIWRNDFN-GLPPVHIIT-----AEYDP--LC--DEGEALYHRMTGQGVQCTCQRY-----------------------------------------------------------------------------------------------------------LGVIHGF---FQLGGISEAARSALRDVAW------------------------------------------- 469
470 -------------------------MKVENKMLGGVETVIITPRSFQAQKEP-------------------GP-A-IIH----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWI-----M---------G--NTDT---TMMLLLQ---AAEETG-FVV-MS------P-E---YR-LA----PE-----------------------------------HPF---PAPYDD--CMNS----------------------------------------------T-----------------------------I--SFMKS-S-------------------------------------KRFN---V-------DPK--------------------------------------------------------K----I-IL--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAM---------------------------------------------------------------------------------------------A--VYIGLIEMQASDPTVELPA------------------MQTLL---Y-----PILQ-TL-----------------NF-------MTPSYEQSRE------FMFNNNLLPKFW---------------------LA-YIGLND-------------------QLELADVVARNSHVDKSDVELIEKWNLVSPNLIPDKYKRGDKVFELDDVVYEDTLNGDVRKLM--KQMILNTKISP----LL-AS-------------------------------------------------N--EII-----------------------------------------------SK----IK---------------------------K-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VL-V-----CEYD---PLRD--DGI-----------LLV-ER-I-----KSL-----------------GGSA--------------------ELHHL--PT-------------S------------------------------------LH------------------------------------------------------------------- 470
471 -------------------------MKVENEMLGGVETVIITPRSFQGKREP-------------------GP-A-IIF----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWV-----M---------G--SING---TATLLIQ---AAEETG-FVV-MS------P-E---YR-LA----PE-----------------------------------HPF---PAPYDD--CMNS----------------------------------------------T-----------------------------I--SFMKS-S-------------------------------------KRFN---V-------DPK--------------------------------------------------------R----I-IL--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAM---------------------------------------------------------------------------------------------A--VYIGLIEMQASDPTVKLPA------------------MQALM---N-----PLLQ-PL-----------------NF-------MTSSYQHYRE------LMFMNNLAPKFL---------------------LA-YIGLND-------------------RPELADVVARNSHVDKSDVELKEKWNLVSPSLIPDKYKQGGKVFELDDVVYDDTLDGDVRKLM--KQMILNTKISP----LL-AS-------------------------------------------------N--KII-----------------------------------------------SK----IK---------------------------K-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VL-V-----CEYD---PLRD--DGI-----------LLV-ER-I-----RSL-----------------GGSA--------------------ELQHL--PT-------------S------------------------------------LHG------------------------------------------------------------------ 471
472 -------------------------MKVENEMLGGVETVIITPRSFQERKKP-------------------GP-A-VVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWV-----F---------A--NLKT---SMHLLVD---FAEETG-FVV-MA------P-E---YR-LA----PE-----------------------------------HPF---PAPYDD--CMNS----------------------------------------------T-----------------------------I--SFMKS-S-------------------------------------KRFN---V-------DPK--------------------------------------------------------K----L-IL--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAM---------------------------------------------------------------------------------------------A--VYIGLIEMQASDPTVELPA------------------MQALI---Y-----PILQ-MI-----------------NY-------LTPSHVQNQK------FMFSADLIPKFW---------------------LA-YIGLND-------------------QPWLGDVVARNSHVDKSDVELIEKWNLVSPNLIPDKYIHSDKVFKLDDVVYDDTLDGDVRKLM--KQMILNTKISP----LL-AS-------------------------------------------------N--EII-----------------------------------------------SK----IK---------------------------K-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VL-V-----CEYD---PLRD--DGI-----------ILH-ER-I-----KAL-----------------GGSV--------------------ELQYL--PN-------------S------------------------------------LH------------------------------------------------------------------- 472
473 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RWAGAVCEQMG-AVA-IA------V-S---YR-LA----PE-----------------------------------FPF---PTPVED--CASS----------------------------------------------I-----------------------------L--HVTEH-A-------------------------------------KAYG---I-------DPT--------------------------------------------------------K----L-FI--S-G--FS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAF---------------------------------------------------------------------------------------------S--SHHLLHTPSKWGYSLPIDPL--------PIC------GIITF---Y-----PLLD-----------------------------YSLTRPEKRSACEKPEFTLAPSLTTLFD---------------------SS-YLPPGV--------------------------------------------------------------------------------------DLLDCRLSP----GI-AP-------------------------------------------------D--EMI-----------------------------------------------EK----LP---------------------------S-------------------------VH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LA-L-----CEYD---MLHA--EGI-----------KFK-ER-L-----ESK-----------------GINV--------------------SVREI--KG-------------E------------------------------------KH------------------------------------------------------------------- 473
474 ------------------------RLKITDTHIRDIRVKVYEPVSGLGRTD--------------------RP-V-LIY----L-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWS------------------LLSVDS-YDPLMRK---ISSDSG-TVV-IS------V-N---YR-LS----PQ-----------------------------------YPF---PVPLND--CLEV----------------------------------------------V-----------------------------E--YVIEN-S-------------------------------------KAMG---I-------DKS--------------------------------------------------------R----I-AV--G-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-MAA---------------------------------------------------------------------------------------------A--ISL----R--LKS---------------KIA------MQMLL---V-----PSLQ-FV-----------------NF-------NTTAFNENTMY--LNRSIHDPNSLMFVI---------------------N--YLGLEP------------KYLSYLRYNN-------HTSPAFKQS-LQNEYADQT-LWLPRRYVRDEKIRE---NMEQPMDTGDEELFERIKNVILDPLVSP----LL-AD-------------------------------------------------D--EHL-----------------------------------------------EN----LP---------------------------Y-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IM-V-----CGYD---FVRD--DGI-----------MFY-ER-L-----NQI-----------------EEEA--------------------HLAYY--PE-------------A------------------------------------FHN--ALFFPHGPLKLNVGVR------------------------------------------------ 474
475 -------------------------LKITDQVMSGIPVRVYEPESSIQQTN--------------------RP-V-LLY----L-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWA------------------FLSIDN-YDHLCQK---LAKDAD-IVV-IS------V-D---YR-LS----PQ-----------------------------------NPY---PAGLDD--VTSI----------------------------------------------V-----------------------------M--HVSEN-S-------------------------------------RSLG---I-------DPG--------------------------------------------------------R----I-AV--G-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--VQL----RPETRG---------------KLS------MLLLL---V-----PVLQ-GV-----------------NM-------KTIGFTENVEY--LHNSINNPGQVVYFF---------------------H--YMSLDH------------SLFNAFRNNL-------HTSAEFKKG-KYRFLFDQR-KYLPAEYIRSAKLKQIGNDIEQ---VGNETLFNELKDKLLTPTIFP----MM-AS-------------------------------------------------D--EEL-----------------------------------------------ST----FP---------------------------F-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VM-A-----AGYD---LIRD--DAI-----------MFA-ER-L-----RHL-----------------NVEV--------------------QLSHF--PD-------------G------------------------------------FHN--DLIMFDGPFKTDVGVRT----------------------------------------------- 475
476 ------------------------ELKIYDTKLAGVDVRIYEPTKGKNSD---------------------RP-A-LVY----Y-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWS------------------WLSIDV-YDQATRQ---LAKGVG-MVV-VS------V-G---YR-QS----PE-----------------------------------YAH---PIPFQD--CLDV----------------------------------------------T-----------------------------E--HVLNN-G-------------------------------------KDLG---I-------DSS--------------------------------------------------------R----V-AI--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LTA---------------------------------------------------------------------------------------------A--VSL----RLK-KKI----------------K------IQVPI---Y-----PCLQ-LF-----------------DM-------QTPSYIENKDY--IPGMLT--DISMLTY---------------------WLNYANISYDHIDTIMANK--HTSPALKKSKYADFI--SPKWYMKEH-IRTESLR-D-MKKPTD-F------------GDE-----K-LSKEIEKTLLDPYFSP----LM-AD-------------------------------------------------D--SDL-----------------------------------------------KD----MP---------------------------L-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VL-T-----AGYD---VLRE--DGL-----------IYY-QR-L-----KKV-----------------GVKV--------------------HLAHY--QE-------------G------------------------------------FHG--MIFFFKGPIPFNVGIR------------------------------------------------ 476
477 -------------------------------NFDSVRVRVYEPAKRKEEY---------------------IP-A-LVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFI------------------ANSIEM-YDEAMLN---IARKLK-MVV-VS------V-D---YR-QS----PQ-----------------------------------YKF---PIPFKD--CCRA----------------------------------------------T-----------------------------R--YMMRN-A-------------------------------------ELFH---V-------NPL--------------------------------------------------------K----I-AV--A-G--DS-----------------TG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--VAM----KLS-QDM----------------S------LQSLA---FQAMLNPTLQ-AI-----------------DF-------TLPSYIQHENV--ATGFVNGRDNVALFY---------------------SM-YA----------LGND--SATESLLDGRAYNKIRRSEKVHMLDH-INHSEV-------PTL-FTKDWHES-SEMRNDG-----D-ISDKLYKLVTNPFFAP----LM-AE-------------------------------------------------D--HQL-----------------------------------------------LN---AVP---------------------------P-------------------------AF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----AGFD---MLRD--DGI-----------LFV-KR-L-----EEN-----------------NITV--------------------KWEHV--HD-------------G------------------------------------FHG--MFPLGGGPISFEAGRHAR---------------------------------------------- 477
478 -------------------------DVEIAGPAGAIPARVYSAGAAEPA-----------------------P-V-IVH----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWV-----V---------G--SLET---HDPFCRY---LCGLTQ-AVI-VS------V-D---YR-LA----PE-----------------------------------HKF---PAAVED--AEAA----------------------------------------------T-----------------------------L--WVL----------------------------------EH----AAELG---G-------DAK--------------------------------------------------------R----V-FV--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--VALLL--SGKA-----------------TLR------GQLLL---F-----PAT---D--------------------------GAPEEYASYQSNATGYGLEAE-SMRWYI---------------------GQ-YLAGEE------------------------------------------------------------------------------------QR--GDPRFAP----VR-AS-------------------------------------------------D--LS-----------------------------------------------------GLP---------------------------P-------------------------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VM-T-----GEYD---VLRD--EGI-----------RYA-ER-L-----TEA-----------------GVAVT-------------------HIH-Y--GR-------------M------------------------------------HHN--FAVWPLTVAALPQSFEARREMA------------------------------------------ 478
479 -------------------------DIKIPGSEANINARVYLPKANGPY-----------------------G-V-LIY----L-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFV-----I---------G--DVES---YDPLCRA---ITNACN-CVV-VS------V-D---YR-LA----PE-----------------------------------YKF---PSAVID--SFDA----------------------------------------------T-----------------------------N--WVY----------------------------------NNLDKFDGKMG---------------------------------------------------------------------------V-AI--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------V--VALLSK--GKL-----------------NLK------YQILI---Y-----PAVG-FD-----------------S--------VS----RSMIEYSDGFFLTRE-HIEWFG---------------------SQ-YLRSPA------------------------------------------------------------------------------------DL--LDFRFSP----IL-VQ-------------------------------------------------D--LS-----------------------------------------------------GLP---------------------------P-------------------------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-T-----AEYD---PLRD--QGE-----------AYA-NR-L-----LQA-----------------GVPVT-------------------SVR-F--NN-------------V------------------------------------IHG--FL---SFFPLIEQGRDAIGLIGS----------------------------------------- 479
480 -------------------------DMTIPVRNGDIKVRVYFPNQRENL-----------------------P-A-VVY----Y-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFV-----Y---------G--NLDT---HDSVCRL---ISKLSN-TII-VS------V-D---YR-LA----PE-----------------------------------HKF---PTQVYD--AYDV----------------------------------------------V-----------------------------K--WLA----------------------------------NN----GGKLS---I-------DTS--------------------------------------------------------K----I-AV--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LST---------------------------------------------------------------------------------------------V--VSILDRDNGEN-----------------VVK------YQIMI---Y-----PVVN-ML-----------------D--------SS----PSMYNYGDGYFLTYE-RILWYN---------------------KQ-YVKEDS------------------------------------------------------------------------------------DY--YNPLASP----IL-AE-------------------------------------------------S---H-----------------------------------------------------NLP---------------------------P-------------------------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-T-----AEYD---PLRD--QGE-----------MYA-HK-L-----KVS-----------------GVKTI-------------------SLR-Y--NG-------------M------------------------------------IHG--FV---SFYEYLDTGKEAIHHIAS----------------------------------------- 480
481 ----------------------NDGIVSRDTEISEVPIRVYQPIARV-GDT--------------------LP-T-IIY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFM------------------LGGLDS-YDETVRS---IMTSFD-IKI-IS------V-G---YR-LA----PE-----------------------------------YTY---PAAYRD--CLAV----------------------------------------------T-----------------------------K--RVLQN-A-------------------------------------DDYY---V-------DID--------------------------------------------------------N----V-AV--M-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--VAQ----KLHLASVNGEEEIP-------ALK------FQALI---Y-----PALQ-SL-----------------TF-------DLPSHLQNDRI------LPTFNDRNTTI---------------------NF-RLTYAFGVIDPEIHDAILRGQLLEKVKQSD------------KA-FLANFVD-D-SNVPDK-YKQRENRV-NASVSEK-----ITIPQKVFRVFTNPSFSP----LM----------------------------------------------------R--KDL-----------------------------------------------RG----LS---------------------------D-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MV-T-----AEFD---VLRD--EGI-----------LYA-KR-L-----ENA-----------------GVDV--------------------TLDHI--ES-------------G------------------------------------FHG------------------------------------------------------------------ 481
482 -----------------------------DEIFDGVRVRVYQPVEKS-DKP--------------------IA-G-MVY----V-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWV------------------VGSVDS-YHYQTNY---IAARLG-IVL-VS------V-D---YR-LA----PE-----------------------------------HPF---PVPLQD--VVKA----------------------------------------------T-----------------------------I--WFLQN-A-------------------------------------KDYN---V-------DPE--------------------------------------------------------R----I-AV--V-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--TAS----LLTFQEKYKQMNLP-------KLK------FQGLI---Y-----PCLQ-SL-----------------DF-------LTPSYQQNKNL-----FILNQHLMVEFW---------------------SW-YLTGHL--------------------KYVAAMKVNNHTSPQVKD-NERKIMG-H-DQIPTE-LKKRDYIP-----PTDFNFGNIGIFTSIQNHLLNPSFAP----LM----------------------------------------------------R--SIV-----------------------------------------------TG----LP---------------------------S-------------------------AY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-T-----AEFD---VLRD--DGI-----------FYV-KK-L-----EDA-----------------NVPV--------------------TWKHY--EH-------------G------------------------------------YHG--IFSVFKGPIASEVG-------------------------------------------------- 482
483 ------------------FSSDEPSVTFHDEIFDGVRVHVYQPVEKS-NEP--------------------IA-G-MVY----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWV------------------FGSVDS-YHHQTNY---MAARLG-IVL-VS------I-D---YR-CA----PE-----------------------------------HPF---PVPLQD--VVKA----------------------------------------------T-----------------------------V--WFLQH-A-------------------------------------KDYN---V-------DPH--------------------------------------------------------R----I-AL--V-G--VS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--TAN----LLTLQEEYKQMSLP-------KVK------FQGLI---Y-----PCLQ-SL-----------------NF-------LTPSYQQNKNF-----FILNQHMMAEFW---------------------SL-YLTGSL--------------------TYVAAMKVNNHTSPPVKK-DQRHIMH-H-DVIPTE-FKQRDYTP-----PNDSDFGDVEISAHLESYILNPSFAP----LM----------------------------------------------------A--STV-----------------------------------------------EG----LP---------------------------P-------------------------AY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-T-----AEFD---VLRD--DGI-----------FYA-KK-L-----EDA-----------------NVPV--------------------TWKHY--KS-------------G------------------------------------WHG--MLTLFTGPLTCAV--------------------------------------------------- 483
484 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDYN---V-------DSS--------------------------------------------------------R----I-GV--L-G--DS-----------------SG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--VAL----KLNRPE---KKNLP-------PLR------FQSLL---Y-----PALQ-AL-----------------DF-------RTDSYKRGNSV-----DILTIDMMAFYW---------------------CL-YLTGSY-------------------VRHPD-------------------FFS-N-NHIPPE-LRKRLYTV--GSVRSKDNNSVMNLPDDM-KDIVNPYFAP----LV-AD-------------------------------------------------D--ADL-----------------------------------------------RG----LP---------------------------P-------------------------AY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----CGFD---VLRD--DGI-----------MYA-KR-L-----QTV-----------------DVPV--------------------VHDHL--ES-------------A------------------------------------FHG--IAVMGFKPFSYSLG-------------------------------------------------- 484
485 ------------------------NVTVTDAEFNGINVRMYEPKIRE-HDL--------------------LP-A-LIF----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWT------------------TLSAEA-YDDVAKD---ITDMIG-QVVLVS------I-D---YS-LA----PE-----------------------------------NFF---PGPANE--CYTA----------------------------------------------T-----------------------------K--WLLKH-A-------------------------------------DNYK---I-------DAK--------------------------------------------------------R----I-GI--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------S--VVL----RLK-SERITP-----------TLK------FQILI---Y-----PALQ-PI-----------------DM-------NLPSYQQNNYAFD---GLLSASVMTYHW---------------------LL-YA----------IGEAPANLTDAILYKQM------LSKVRRSSHSRLTKYIH-H-SLLPEH-CKTRGFDP-DI--EVKRAV--KEIPDYILRILLHPYFAP----LL-AD-------------------------------------------------D----L-----------------------------------------------SG----LP---------------------------Q-------------------------AY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----GEFD---VLRD--DGI-----------LYA-ER-L-----KEA-----------------MVKV--------------------TLNNI--AD-------------G------------------------------------FHG--MLS------------------------------------------------------------- 485
486 ---------------------------VTDTMFDGINVRIYEPRASQ-YDM--------------------LP-A-LVF----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWA------------------TLSVED-YDEVTRD---IADLMG-QVVLIS------I-D---YN-LA----PE-----------------------------------HIF---PGPVND--CYKA----------------------------------------------T-----------------------------K--WLLQH-A-------------------------------------ADYG---I-------DEN--------------------------------------------------------R----I-GI--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------S--VVL----RLK-VDKVTP-----------KLA------FQVLV---Y-----PALQ-SI-----------------DF-------TLPSYQQNKYAFD---GLITTSYMPYYW---------------------LI-YA----------IGEAPRNLTDAMLKKQA------VSELRRLKNGRLANYIN-H-SLLPET-YKSRGYDP-NMHTNIKKSV--KEIPNNILRIFVDPYFAP----LL-AE-------------------------------------------------D----L-----------------------------------------------SG----LP---------------------------E-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-T-----AEFD---VLRD--DGI-----------LYY-ER-L-----KEA-----------------GVQV--------------------TLNNV--VS-------------G------------------------------------FHG------------------------------------------------------------------ 486
487 ----------------------------------KIPVRIYTPENGSN-----------------------FP-I-IIY----S-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------FWI------------------GGNVDT-SDRVCRK---LSQNTK-AIV-IS------V-N---YR-LA----PE-----------------------------------NSF---PAGLND--VYNV----------------------------------------------L-----------------------------Q--WTYKN-A-------------------------------------KSIN---G-------DEK--------------------------------------------------------H----I-AV--V-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LSA---------------------------------------------------------------------------------------------A--VSSMSRDKNGP-----------------PIT------CQVLI---Y-----PSTN-IF-----------------EL-------NSKSWSYFSNS-----VNVSREDMEKYI---------------------SI-YAPKKE--------------------------------------------------------------------------------------DRKNPYASP----LL---------------------------------------------------------------------------------------------------------SKDFSKLP---------------------------D-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-T-----AEID---PLRD--EGE-----------AYA-NK-L-----KES-----------------GVKV--------------------DVARY--KG-------------I------------------------------------THG--FITMDKITNKADEALNQISLYI------------------------------------------ 487
488 -------------------------------METEIPIRIYYPDNKRDH-----------------------P-I-ILH----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------AWI-----L---------G--SIET---EDSVSRI---LANSCN-CIV-IS------V-N---YR-LA----PE-----------------------------------HKF---PAAVTD--CFDS----------------------------------------------I-----------------------------K--WTY----------------------------------EN----AESIG---G-------HPN--------------------------------------------------------R----I-AV--F-G--IS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--TSILSRDQG-I-----------------KLR------AQALV---V-----PFVY-LD-----------------L--------AS----TSMTEYRKGYFLDINVPIDYGI---------------------MM-YIRDEK------------------------------------------------------------------------------------DL--LNPMFVP----LI-AE-------------------------------------------------D--LS-----------------------------------------------------NLP---------------------------Q-------------------------AI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-T-----AEYD---PLRD--QGE-----------AYA-KR-L-----MEA-----------------GVLTL-------------------SFR-V--NG-------------M------------------------------------VHG--FLGSPNISRLVSVMVGSALK-------------------------------------------- 488
489 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HDALMRR---FVRKKR-MLI-VS------V-E---YR-LA----PE-----------------------------------FPF---PVPAED--CITA----------------------------------------------T-----------------------------R--YFLRH-S-------------------------------------KKYR---A-------DPK--------------------------------------------------------R----I-GV--M-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--VSQ----ALTGPD---FTDLP-------KLK------VQVLI---Y-----PALQ-AF-----------------QF-------RSPAYVKYAGS-----SVPGLLNAERMS---------------------EF-WLRYAY-------------GRDYLKANHLDLLAGKHLTEEWLNS-KEASYVD-V-KHLPQK-LREGYATS-ANSVPN------VTLSNFVKTVFLNPLFSP----LL-AD-------------------------------------------------G--EKI-----------------------------------------------RG----SP---------------------------S-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ML-T-----AEFD---PLRD--DGF-----------YMT-KR-L-----REM-----------------NVAV--------------------EHRHF--TG-------------M------------------------------------DHG------FLSVFSYQNSVKAVTEI------------------------------------------- 489
490 -----------PIPVSRVQDLYLDGNDLDVQGCTGFRVRVYNPALEPGEKPTT------------------YP-I-LMW----F-------H---------------------------------------------------------S--------------------G---------------------------------------------------------------------------------GFV-----S---------K--SIQTPS-VDGLCRL---LSNQSR-CVV-VS------V-D---YR-LA----PE-----------------------------------NMF---PAAALD--CFAA----------------------------------------------T-----------------------------C--WAVKK-A-------------------------------------ATFD---G-------DPT--------------------------------------------------------R----I-AV--A-G--DS-----------------VG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--VALMARDKETP-----------------RLC------GQVLV---C-----PILD-----------------------------LKKNEEKYYTRVVHNDGYLMPMSFFKWF---------------------SSKYCREAD---------------------------------------------------------------------------------------IENPYASP-------LK-------------------------------------------------A--ATS-----------------------------------------------TKALCGLP---------------------------V-------------------------TH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MI-T-----AGFD---PFCD--EGE-----------LYI-KK-L-----RQS-----------------GVKV--------------------YHTRY--TN-------------S------------------------------------PHG------------------------------------------------------------------ 490
491 -------------------------VKISSDILGGVPVRIYEPTGHR-SSG--------------------SP-A-LIW----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWV------------------SKSARS-DDSLMTE---LSRRLE-IPI-VS------I-D---YR-LA----PE-----------------------------------HIY---PAAFDD--CFDA----------------------------------------------S-----------------------------L--AFVQS-A-------------------------------------EKYG---V-------DPR--------------------------------------------------------R----I-AI--S-G--AS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--VSL----KFRDTQQPV------------SFR------RQVLI---V-----PCLQ-MF-----------------DL-------NTPSYQANNHD-----AFLPKYWMTYFW---------------------LW-YG----------FGAKGHERASEFMSNT-------HTSPAAKQS-ELASYVK-H-AYLPAK----YMYTS---YTPNQSNFGNGTLWNEVKGVMTDAYFAP----LM-AK-------------------------------------------------D----L-----------------------------------------------SR----LP---------------------------P-------------------------AY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IA-T-----AQYD---VLRD--DGI-----------MFH-KR-L-----EGS-----------------GTSS--------------------KLMNY--EG-------------G------------------------------------FHA--MIDF------------------------------------------------------------ 491
492 -----------------------------------VPVVIYRPLTDR-GL---------------------RP-A-LVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWV-----M---------ARAWSQFSL-H----KH---LAGELD-IIV-IS------V-D---YR-RA----PV-----------------------------------FRY---PVPFED--CVRA----------------------------------------------T-----------------------------K--YILAH-G-------------------------------------EKLG---V-------HST--------------------------------------------------------R----V-AL--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--VSA----KLR-DEKFTP-----------RNK------LQVLI---Y-----PALQ-AC-----------------DL-------ATPSYQQQK----FDRIVMAPEVMAWYW---------------------SI-YV----------TGNH--SLAEALLRGN-------HTSIKMKQE-LATGKLN-H-DLIPNH-LKFAPYSV-PDISHGS-----DVIWDSIREVFLDPYFAP----LV-AD-------------------------------------------------D----F-----------------------------------------------TD----LP---------------------------S-------------------------TF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VW-T-----VQYD---VLRD--DGV-----------LYV-HH-L-----RRA-----------------GNQV--------------------EHLHT--EG-------------G------------------------------------WHP--MLEL------------------------------------------------------------ 492
493 ----------------------DGTLWVEDKVFDGVQVRVYTPRGLSVTP---------------------SP-A-LIN----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWA-----YLDIDG--------------YDAFCRR---VAKHAN-IVV-IS------I-D---YR-RA----PE-----------------------------------YPF---PVPLDD--CVTA----------------------------------------------V-----------------------------K--YFISN-A-------------------------------------QKFN---V-------DQN--------------------------------------------------------R----I-GL--T-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAM---------------------------------------------------------------------------------------------A--TALRL-----QKEDVP------------KLK------LLSLM---Y-----PTLQ-SF-----------------DL-------NLPSYLENPDRRST--SFCMKDTLIHCM---------------------QL-YAFGNE--------------------------PL-TSAMIKNIHISKEDREKYS-KYINMEMLPSKYRKERVTSEVAPTTSGTVKGVD--TSIFLNPYFSP----LL-AS-------------------------------------------------D--DDL-----------------------------------------------RK----LP---------------------------K-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VM-T-----ADID---ALRD--DGF-----------LLA-NR-M-----KTL-----------------GLDL--------------------DHEHM--EG-------------L------------------------------------EHG--FVLFFYYKSS------------------------------------------------------ 493
494 ------------------------------THFDGVSVRVYVPISRRDGDL--------------------LP-G-VVY----L-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWV------------------LGSPES-EENIGRE---LTKRLN-AVV-VS------V-D---YR-MA----PE-----------------------------------VTF---PTSFED--SLRA----------------------------------------------T-----------------------------K--YFLTH-T-------------------------------------EKFG---V-------DAS--------------------------------------------------------R----V-AV--A-G--NS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-MAA---------------------------------------------------------------------------------------------T--VSL----KLR-DDQFEP-----------RVK------RQVLI---Y-----PVVQ-FV-----------------DY-------QMPSYQQNAYA-----PILKRPLLVYFL---------------------SM-QL----------YGNR--SLENVISNNK-------HVTRDVRET-IGASYMD-Y-AWLPNEFLELSPFED-NGFLEGD-----AEVWNSIKDAVMSPYMSP----LF-AK-------------------------------------------------H----L-----------------------------------------------GD----LP---------------------------D-------------------------AF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI-T-----CQYD---MLRD--EGY-----------LYA-RR-M-----EQF-----------------GTKV--------------------KYVNY--KS-------------T------------------------------------FHG------------------------------------------------------------------ 494
495 ----------------------DSTLHIRDTHFDGVSVRVYVPISRRDGDL--------------------LP-G-VVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWV------------------LGSTES-EDNIARE---LTKRLN-AVV-VS------V-D---YR-MA----PE-----------------------------------VTF---PIPFED--SLRA----------------------------------------------T-----------------------------K--YFLTH-T-------------------------------------ETFG---V-------DPS--------------------------------------------------------R----V-AV--A-G--NS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-MAA---------------------------------------------------------------------------------------------T--VSL----KLR-DEQFEP-----------KLK------RQVLI---Y-----PAVQ-FV-----------------DY-------QTPSCQQSEKA-----PVLKRHLKVYFL---------------------SM-HL----------YGNR--SLENVIGDNR-------HVTRDVREN-IRVSYMD-Y-SWLPNEFLELGPYQD-KEIVEGD-----VDVWNSIKDAVMSPYMSP----LF-AK-------------------------------------------------H----L-----------------------------------------------GD----LP---------------------------D-------------------------AF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI-T-----CQYD---MLRD--EGY-----------LYA-RR-M-----KQF-----------------GTKV--------------------KYVNF--KN-------------S------------------------------------FHG------------------------------------------------------------------ 495
496 -------------------AGSDPLLKIRDTNFDGVPVRVYTPVESK--DL--------------------LP-G-FVY----Y-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWE------------------FGSRDT-VEMICRE---ISKRVN-AVV-VS------V-E---YR-MA----PE-----------------------------------VTF---PIPFED--GLRA----------------------------------------------T-----------------------------K--HFLTH-A-------------------------------------EKLG---V-------DPT--------------------------------------------------------R----V-GI--G-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-MAA---------------------------------------------------------------------------------------------A--VSL----KLR-DKKFEP-----------KVK------QQVLI---Y-----PAVQ-SV-----------------DF-------HTPSYQQNAFA-----PMLKATHMHYYT---------------------SM-HL----------TGNK--SLMKVIESNR-------HVSKDVQEA-VRASYID-Y-AWLPKEFREQSPYED-QGVVEGD-----AEVWNSIKDAVMSPYMSP----LL-AK-------------------------------------------------N----L-----------------------------------------------GD----LP---------------------------D-------------------------AY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI-T-----CGYD---VLRD--EGY-----------LYA-QR-M-----KEF-----------------GTKV--------------------KYVNY--EN-------------T------------------------------------FHG--VL-------------------------------------------------------------- 496
497 ------------------PPTSDENVTVMETTFNNVPVRVYV-PKRKPERL--------------------RR-G-LFY----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWC-----L---------G--SAAFLG-YDSLSRR---TADRLD-AVV-IS------T-N---YR-LA----PK-----------------------------------YHF---PNQFED--VYNA----------------------------------------------L-----------------------------K--GFMRQ-DVL-----------------------------------DKYG---V-------DPE--------------------------------------------------------R----I-GI--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--VAQ----QLIDDPDVEI-----------NLK------TQCLI---Y-----PALQ-TL-----------------DM-------DLPSYRENSHF-----PILPKSLMVRFW---------------------SE-YFTVDK------------SLVKAMFSNQ-------HVPVESSHLYKF---INWS-SLLPEKFKKGYFYKS-PTYGSSE--------LAKKYPGFLDVRAAP----LL-AD-------------------------------------------------D--NKL-----------------------------------------------RS----LP---------------------------L-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI-T-----CQYD---VLRD--DGI-----------MYV-TR-L-----QNA-----------------GVQV--------------------THNHI--ED-------------G------------------------------------FHG--AF----SFSGFKIADRLENQ-------------------------------------------- 497
498 ------------------PPTSDENVTVTETKFNNILVRVYV-PKRKSEAL--------------------RR-G-LFY----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWC-----V---------G--SAALSG-YDLLSRW---TADRLD-AVV-VS------T-N---YR-LA----PK-----------------------------------YHF---PIQFED--VYNA----------------------------------------------L-----------------------------R--WFLRK-KVL-----------------------------------AKYG---V-------NPE--------------------------------------------------------R----I-GI--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--VTQ----QLLDDPDVKI-----------KLK------IQSLI---Y-----PALQ-PL-----------------DV-------DLPSYQENSNF-----LFLSKSLMVRFW---------------------SE-YFTTDR------------SLEKAMLSRQ-------HVPVESSHLFKF---INWS-SLLPERFIKGHVYNN-PNYGSSE--------LAKKYPGFLDVRAAP----LL-AD-------------------------------------------------D--NKL-----------------------------------------------RG----LP---------------------------L-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI-T-----CQYD---LLRD--DGL-----------MYV-TR-L-----RNT-----------------GVQV--------------------THNHV--ED-------------G------------------------------------FHG--AF----SFLGLKISHRLINQ-------------------------------------------- 498
499 ------------------PPTSDENVTVMETTFNNVPVCIYV-PKXKPERL--------------------RR-G-LFY----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWC-----L---------G--SAALFS-YAFLSKQ---TVDRFD-VVV-IS------V-N---YR-LA----PK-----------------------------------YHF---PXQFED--VYNA----------------------------------------------L-----------------------------K--WFLHQ-DVL-----------------------------------DKYG---V-------DPE--------------------------------------------------------R----I-GI--P-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--VTQ----QLIDDSDVKI-----------KLK------TQSLI---Y-----PALQ-TL-----------------DM-------DLPSYWENSHF-----PPLPKSLMVQFW---------------------SE-YFTTDK------------SLAKAMLFKQ-------HVPVESSHLFKF---INWS-SLLPEKFKKGHFYNS-PTYGSSE--------LAKKYPGFLDVRASP----LL-AD-------------------------------------------------D--NKL-----------------------------------------------RS----LP---------------------------L-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI-T-----CQYD---VLRD--DGI-----------MYV-TX-L-----QNA-----------------GVQV--------------------THNHI--ED-------------G------------------------------------FHG--AL----SNYALKITHRVENQ-------------------------------------------- 499
500 ------------------PPTSDENVAVTETTFNHIPVRVYV-PKRKSEAL--------------------RR-G-VFY----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWC-----L---------G--SAALKG-YDSLSRW---TADRLD-AVV-IS------T-D---YR-LA----PK-----------------------------------YHF---PTQFED--VYNA----------------------------------------------L-----------------------------K--WFLRE-KVL-----------------------------------AKYG---V-------NPE--------------------------------------------------------R----V-AV--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--VTQ----QLLDDPDVKI-----------KLK------VQSLI---Y-----PALQ-PL-----------------DV-------DTPSYQGYSHF-----PVLSKSLMVRFW---------------------SE-YFTTDR------------SLEKAMLSHQ-------HVPVESSHLFKF---VNWS-SLLPERFIKGYVYNN-PIYGSSE--------LSKKYPGFLDVRAAP----LL-AD-------------------------------------------------D--HKL-----------------------------------------------RG----LP---------------------------L-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-T-----CQYD---VLRD--DGL-----------MYV-SR-L-----RNA-----------------GVRV--------------------THNHV--ED-------------G------------------------------------FHG--SF----SLLNFKIGYRLINQ-------------------------------------------- 500
501 ------------------PPTSDEHVTVMETAFDSVPVRIYI-PKRKSMAL--------------------RR-G-LFY----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWC-----L---------G--SAAHFS-YDTLSRW---TAHKLD-AVV-VS------T-D---YG-LA----PK-----------------------------------HHF---PRQFED--VYRS----------------------------------------------L-----------------------------R--WFLQE-DVL-----------------------------------EKYG---V-------DPR--------------------------------------------------------R----V-GV--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--VTQ----QLIQDPDVKI-----------KLK------VQALI---Y-----PALQ-AL-----------------DT-------NVPSQQEGSHF-----PVLTRSLMVRFW---------------------SE-YFTTDR------------GLEKAMLLNQ-------HVPMESSHLLQF---VNWS-SLLPERYKKSPVYKN-PTPGSSE--------LAQKYPGFIDVKACP----LL-AN-------------------------------------------------D--NIL-----------------------------------------------HH----LP---------------------------K-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-T-----CQYD---VLRD--DGL-----------MYV-KR-L-----QNV-----------------GVHV--------------------THHHV--ED-------------G------------------------------------FHG--TF----SFPGLKLSERMKNQ-------------------------------------------- 501
502 -------------------PVSDEKVTVTDTKMNDVPVRLYV-PKEKPDSL--------------------KR-A-VIF----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWC-----L---------G--GTAMSS-YDLLSRW---TSERLN-AVV-IS------I-E---YR-LA----PK-----------------------------------YHF---PVQFED--VYAV----------------------------------------------T-----------------------------K--YFLQR-SVL-----------------------------------EEHK---V-------DPE--------------------------------------------------------R----V-CI--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--VTQ----QLLDDPDVKV-----------KLK------IQVLI---Y-----PALQ-TI-----------------DM-------NLPSYQDNKNM-----PILPKSLMLRFW---------------------SE-YFTTDL------------SLMEAIETNQ-------YVPPEFSHLFKF---VNWS-EWLPERFKRDHVYTS-PVPGKSK--------FGQKYPGFFDPRAAP----LL-VD-------------------------------------------------D--VKL-----------------------------------------------RG----LP---------------------------L-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI-T-----CQHD---VLRD--DGL-----------MYV-SR-L-----RKV-----------------GVPV--------------------IHEHL--EG-------------A------------------------------------IHG------------------------------------------------------------------ 502
503 -------------------PTSDENVTVTDTELSGVAVRLFL-PKKPADGL--------------------QR-A-VLY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWC-----V---------G--DAGMKG-YDFLARR---TSSQLN-AVV-VS------V-N---YR-LA----PK-----------------------------------YHF---PVQFED--VYSV----------------------------------------------S-----------------------------K--FFLQS-RVL-----------------------------------SQYG---V-------DPT--------------------------------------------------------R----V-CV--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--VAQ----KLLEDSEVTT-----------KLK------AQALI---Y-----PALQ-TL-----------------DL-------NLPSYHQNADM-----PVLSKSLMVRFW---------------------SE-YFTSDP------------SLREAITSNR-------HVPAQWGHLFQF---VNWS-TLLPDRMKKGHVYTG-PVFGSPA--------LAKKYPGFLDRRAAP----LL-AA-------------------------------------------------E--AQL-----------------------------------------------RG----LP---------------------------P-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----CEHD---VLRD--DGV-----------MYA-TR-L-----KAA-----------------GVPV--------------------THEHA--ED-------------G------------------------------------FHG--ALIFVTSPADMAVGHRLLGR-------------------------------------------- 503
504 ---------------------SSEPINITDVVFDGVEVRVFEPPAKQDEPL--------------------KR-S-VVY----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWA-----L---------A--SARTSL-YNNLCRI---MAESLN-AVV-VS------I-E---YR-LV----PE-----------------------------------VCF---PEQFHD--ALRA----------------------------------------------T-----------------------------K--HFLQP-DVL-----------------------------------AEYS---V-------DPN--------------------------------------------------------R----I-AI--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--VCQ----QLSKDELLIV-----------RPK------LQALI---Y-----PVLQ-AF-----------------DF-------NTPSYQQNMNM-----PVLPRYVMINYW---------------------ID-YFNGNY------------DLAHSLLINN-------HTALDVHQALTFRGRLNWT-SLLPSSFKKNYKPVV-QTTGNAE--------IIQEIPALLDVRAVP----LL-AE-------------------------------------------------N--ETL-----------------------------------------------QL----QP---------------------------K-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----CEND---VLRD--DGV-----------MYA-KR-L-----ENA-----------------GVEV--------------------TLDHF--DD-------------C------------------------------------FHG--CMIFTIWPTDFSAGVQTRNS-------------------------------------------- 504
505 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGGY-YNNLCLV---MAESLD-AVI-VS------I-E---YR-LV----PD-----------------------------------FHF---PAQFDD--VMNA----------------------------------------------V-----------------------------K--HFMLP-EVL-----------------------------------AHYS---V-------DPN--------------------------------------------------------R----V-AI--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--VCQ----EMTQEENVTN-----------QFK------LQALI---Y-----PVLQ-PL-----------------DF-------NTPSYQQNEIT-----AVLSRFVMVKFW---------------------LD-YFNGDY------------DFAFSMMMNN-------HTALDVDLVSPFRERLDWT-FLLPSRFRKNYKPAV-PATGKAE--------IIQALPALLDVRAAP----LL-AE-------------------------------------------------R--EVF-----------------------------------------------RL----QP---------------------------K-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----CEID---VLRD--DGL-----------MYA-KR-L-----EKA-----------------GVEV--------------------TVDHF--ED-------------C------------------------------------FHG--CMIFTVWPTNFFAGHLTRDSYIKWLDQNL----------------------------------- 505
506 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YDELCTA---MAEELN-AVI-VS------I-E---YR-LV----PK-----------------------------------VYF---PAQIHD--VVRA----------------------------------------------T-----------------------------K--YFLQP-EVL-----------------------------------HKYS---V-------DPG--------------------------------------------------------R----I-GI--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--LGQ----QFTQDANLKD-----------KLK------VQALI---Y-----PVLQ-AL-----------------DF-------NTPSYQQNVNT-----PILPRYVMVKYW---------------------VD-YFKGNY------------DFVQAMVVNN-------HTSLDVEEAVALRARLNWT-SLLPPSLTKDYKPVV-QTTGNAR--------IVREIPQLLDARSAP----LI-AD-------------------------------------------------Q--KVL-----------------------------------------------QH----LP---------------------------K-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----CEHD---VLRD--DGI-----------MYA-KR-L-----ESA-----------------GVEV--------------------TLDHF--ED-------------G------------------------------------FHG--CMIFTSWPTNFDVGIRTRNS-------------------------------------------- 506
507 -------------------AWSSAQVKVTDTDFDGVEVRVFEGPPKPEEPL--------------------KR-S-VVY----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWA-----L---------A--SAKIRY-YDELCTA---MAEELN-AVI-VS------I-E---YR-LV----PK-----------------------------------VYF---PEQIHD--VVRA----------------------------------------------T-----------------------------K--YFLKP-EVL-----------------------------------QKYM---V-------DPG--------------------------------------------------------R----I-CI--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--LGQ----QFTQDASLKN-----------KLK------LQALI---Y-----PVLQ-AL-----------------DF-------NTPSYQQNVNT-----PILPRYVMVKYW---------------------VD-YFKGNY------------DFVQAMIVNN-------HTSLDVEEAAAVRARLNWT-SLLPASFTKNYKPVV-QTTGNAR--------IVQELPQLLDARSAP----LI-AD-------------------------------------------------Q--AVL-----------------------------------------------QL----LP---------------------------K-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----CEHD---VLRD--DGI-----------MYA-KR-L-----ESA-----------------GVEV--------------------TLDHF--ED-------------G------------------------------------FHG--CMIFTSWPTNFSVGIRTRNS-------------------------------------------- 507
508 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YDELCTA---MAEELN-AVI-VS------I-E---YR-LV----PK-----------------------------------VYF---PAQIHD--VVRA----------------------------------------------T-----------------------------K--YFLQP-EVL-----------------------------------HKYS---V-------DPG--------------------------------------------------------R----I-GI--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--LGQ----QFTQDANLKN-----------KLK------VQALI---Y-----PVLQ-AL-----------------DF-------NTPSYQQNVNT-----PILPRYVMVKYW---------------------VD-YFKGDY------------DFVQAMIVNN-------HTSMDVEEAVALRARLNWT-SLLPASITKGYKPVV-QTTGNAR--------ILREIPQLLDARSAP----LI-AD-------------------------------------------------Q--EVL-----------------------------------------------RH----LP---------------------------K-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----CEHD---VLRD--DGI-----------MYA-KR-L-----ESA-----------------GVEV--------------------TLDHF--ED-------------G------------------------------------FHG--CMIFTSWPTNFSVGIRTRNS-------------------------------------------- 508
509 -------------------AWSSAQVKVTDTDFDGVEVRVFEGSPKPGEPL--------------------KR-S-VVY----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWA-----L---------A--SAKIRY-YDELCAA---VAEELN-AVV-VS------I-E---YR-LV----PK-----------------------------------VYF---PAQIND--VVRA----------------------------------------------T-----------------------------K--YFLQP-EVL-----------------------------------HKYS---V-------DPD--------------------------------------------------------R----I-GI--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--LGQ----QISQDANLKN-----------KLK------VQALI---Y-----PVLQ-AL-----------------DF-------NTPSYQQNVNS-----PILPRYVMVKYW---------------------VD-YLKGNY------------DFVEAMTVNN-------HTSLDVEEAVALRARLNWT-ALLPPSVTKNYKPVV-QTAGNAR--------IIQEIPELLDARSAP----LI-AD-------------------------------------------------Q--EVL-----------------------------------------------QQ----LP---------------------------K-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----CEHD---VLRD--DGL-----------MYA-KR-L-----ESA-----------------GVEV--------------------TLDHF--ED-------------G------------------------------------FHG--CMIFTSWPTNFSVGIRTRNS-------------------------------------------- 509
510 -------------------ARSSPKVKVTDTDFDGVEVRVFEGSPKPEEPL--------------------RR-S-VIY----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWA-----L---------A--SAKISY-YDQLCTT---MAEELN-AVI-VS------I-E---YR-LV----PQ-----------------------------------VYF---PEQIHD--VIRA----------------------------------------------T-----------------------------K--YFLQP-EVL-----------------------------------DKYK---V-------DPG--------------------------------------------------------R----V-GI--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--LGQ----QFTYVASLKN-----------KLK------LQALV---Y-----PVLQ-AL-----------------DF-------NTPSYQQSMNT-----PILPRHVMVRYW---------------------LD-YFKGNY------------DFVEAMIVNN-------HTSLDVERAAALRARLDWT-SLLPSSIKKNYKPIM-QTTGNAR--------IVQEIPQLLDAAASP----LI-AE-------------------------------------------------Q--EVL-----------------------------------------------EA----LP---------------------------K-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----CEHD---VLRD--DGI-----------MYA-KR-L-----ESA-----------------GVNV--------------------TLDHF--ED-------------G------------------------------------FHG--CMIFTSWPTNFSVGIRTRNS-------------------------------------------- 510
511 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MLP-YDYLNRW---TANKLD-AVV-VG------I-D---YR-LA----PQ-----------------------------------YPF---PAALED--CVLV----------------------------------------------I-----------------------------K--YFLQD-TIL-----------------------------------KKYG---V-------DPT--------------------------------------------------------R----I-CI--S-G--DS-----------------CG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-LAT---------------------------------------------------------------------------------------------T--AIQ----LLQNNPEHKD-----------KIK------AQALL---Y-----PGLQ-FI-----------------DT-------LMPSHRINEHG-----PFLSREIAIKLA---------------------YL-YVTEDT------------ALVQAMQRNE-------HMPKGSRHLFKF---VNWS-DFLPEKYKKNYVYTE-PTLG--K--------LNVFYPALLDSRLSP----LL-VN-------------------------------------------------D--SQL-----------------------------------------------QS----LP---------------------------L-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----CEHD---ILRD--DGL-----------IYS-TR-L-----RNV-----------------GVQV--------------------THDHI--ED-------------G------------------------------------IHG--AILLITVPCNLHLAVRIRDK-------------------------------------------- 511
512 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSA-YDDLNRW---TANKLD-AVV-VG------I-D---YR-LA----PK-----------------------------------YPF---PAALED--CVYT----------------------------------------------I-----------------------------K--FFLQK-NIL-----------------------------------AKYR---V-------DPT--------------------------------------------------------R----I-CI--M-G--DS-----------------SG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-LAA---------------------------------------------------------------------------------------------T--VTQ----LLQNDPNFKD-----------KIK------AQALM---Y-----PGLQ-SL-----------------DT-------LLPSHQEYQHG-----PILTREMIIKLA---------------------CL-YVTEDK------------VLLQAALRNE-------HMPTESRHLFKF---VNWS-DFLPEKYKKNYVYTE-PILG--K--------LNASYPVLVDSRLSP----LL-FN-------------------------------------------------D--TQL-----------------------------------------------QS----LP---------------------------L-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-T-----CEHD---LLRD--DSL-----------IYI-SR-L-----RNV-----------------GVKV--------------------THEHI--EK-------------G------------------------------------IHG--ALSFTRAPVFLNLGLKIRDK-------------------------------------------- 512
513 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TA-YDFLNRW---TANKLG-AVV-VG------I-D---YR-LA----PQ-----------------------------------YQF---PVALED--VLSV----------------------------------------------V-----------------------------R--FFLQD-NIL-----------------------------------AKYG---V-------DPS--------------------------------------------------------R----I-CI--S-G--DS-----------------SG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-LAA---------------------------------------------------------------------------------------------E--VTQ----LVQNDPEFKN-----------KIK------AQVLI---Y-----PGLQ-AV-----------------DV-------LMPSHRQNEHG-----PILSRDMAIKMG---------------------CL-YLTKDK------------ALAQAVRENQ-------HMPHGSRHLFKL---VNWS-TLLPEKYRRNHIYTE-PIIG--K--------LNSSYPVLLDSRLSP----LL-VT-------------------------------------------------D--SQL-----------------------------------------------EK----LP---------------------------L-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-T-----CEHD---ILRD--DGL-----------IYV-SR-L-----RNA-----------------AVNV--------------------SHDHI--ED-------------G------------------------------------IHG--ALFFMTSPFYLNVGIRISDK-------------------------------------------- 513
514 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-S---YR-LA----PQ-----------------------------------HHF---PVQFED--CLAA----------------------------------------------V-----------------------------K--FFLQD-EIL-----------------------------------AKYG---V-------DPT--------------------------------------------------------R----I-CI--S-G--DS-----------------SG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-LAA---------------------------------------------------------------------------------------------G--VTQ----QVQTDAGFKH-----------KIK------IQALL---Y-----PSLQ-II-----------------DS-------YLPSHQENEHG-----IILPRDLAIKLV---------------------SL-YLTKDE------------TFVEAMRRNE-------HMPQESRHLFQF---VNWS-TLLPEKYRKGYVYTE-PILG--K--------HNFSFPGLMDIRISP----LL-AN-------------------------------------------------D--SLL-----------------------------------------------QN----LP---------------------------P-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----CQYD---IVRD--DGL-----------MYV-SR-L-----QNV-----------------GVQV--------------------THDHI--EN-------------G------------------------------------IHA--ALSFMTPPLYLHVGLRIRDM-------------------------------------------- 514
515 RIMRYEEFISMIFRLDYTQPLSDEYITVTDTTFVDIPVRLYL-PKRKSETR--------------------RR-A-VIY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFC-----F---------G--SSKQRA-FDFLNRW---TANTLD-AVV-VG------V-D---YR-LA----PQ-----------------------------------HHF---PAQFED--GLAA----------------------------------------------V-----------------------------K--FFLLE-KIL-----------------------------------TKYG---V-------DPT--------------------------------------------------------R----I-CI--A-G--DS-----------------SG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAT---------------------------------------------------------------------------------------------A--VTQ----QVQNDAEIKH-----------KIK------MQVLL---Y-----PGLQ-IT-----------------DS-------YLPSHRENEHG-----IVLTRDVAIKLV---------------------SL-YFTKDE------------ALPWAMRRNQ-------HMPLESRHLFKF---VNWS-ILLPEKYRKDYVYTE-PILG--G--------LSYSLPGLTDSRALP----LL-AN-------------------------------------------------D--SQL-----------------------------------------------QN----LP---------------------------L-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----CQHD---LLRD--DGL-----------MYV-TR-L-----RNV-----------------GVQV--------------------VHEHI--ED-------------G------------------------------------IHG--ALSFMTSPFYLRLGLRIRDM-------------------------------------------- 515
516 GIMKYEEFVSIIFKLDYTDPLSDEHVTVIETAFADIPVRLYT-PKRKSEMP--------------------RR-A-VIY----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------AFC-----F---------G--SFKQMS-FDFLNRW---TANKLD-AVV-VG------L-D---YR-LA----PQ-----------------------------------HQF---PAQFED--SFAA----------------------------------------------V-----------------------------K--FFLQD-EVL-----------------------------------TKYR---V-------DPT--------------------------------------------------------R----I-CI--A-G--DS-----------------FG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-LAA---------------------------------------------------------------------------------------------A--VTQ----QVQNNLEIQH-----------KIK------LQALL---Y-----PSLQ-LI-----------------DS-------YLPAHRDNEYG-----LILTRKTGIKLI---------------------SL-YLTASE------------TLSLAVLRNQ-------HMPLESAHLFKF---VNWS-SLLPKKYRKDYVYTE-PVLG--R--------CNHSLPAFMDIRASP----LL-AN-------------------------------------------------D--SQL-----------------------------------------------RN----LP---------------------------S-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----CQYD---LVRD--DGF-----------MYT-SR-L-----QNV-----------------GVQV--------------------THDHL--ED-------------G------------------------------------IHG--ALLFMTSPLHLHLGLRIKD--------------------------------------------- 516
517 ---------------------------IEDLWFEKVPVRIYQPKAPSASP---------------------RR-G-VMF----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWV-----F---------G--SLET---HESLCRS---LARGSE-SVV-VS------V-G---YR-LA----PE-----------------------------------HKY---PAAYED--CLNA----------------------------------------------T-----------------------------V--HFMRN-A-------------------------------------EHYG---V-------DPA--------------------------------------------------------C----I-SV--C-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--VSQ----TLAGRADLP------------RLR------AQILI---Y-----PILQ-AL-----------------DF-------NLPSYKQNQGV-----PPLFQERAVFYV---------------------LQ-YLNGNT---------------------------SNLEQVLEGSHIPIDIKLNYR-KWVSEDYIPEKFKVRGYKPH-VLLDCST--EVYETVKRFCEPNLCP----LL-AE-------------------------------------------------D--AVV-----------------------------------------------HQ----LP---------------------------E-------------------------SF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----CEYD---VLRD--DGL-----------LYK-KR-L-----EDN-----------------GVRV--------------------TWCHL--ED-------------G------------------------------------FHG--IINSFNSE-------------------------------------------------------- 517
518 -------------------LRLDPKLFIQDLQFNKVPVRVYQPKATSHGR---------------------RR-G-ILF----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWV-----F---------G--SLDT---YEKVCRY---LSRESE-SVV-VS------V-Q---YR-LA----PE-----------------------------------HKY---PAAYED--CLNA----------------------------------------------T-----------------------------V--HFMRN-A-------------------------------------EHYG---V-------DPA--------------------------------------------------------C----I-SV--C-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--VSQ----TLAGRADLP------------RCV------AQILI---Y-----PGLQ-AL-----------------DF-------NLPSYHQNRGV-----PLLFRERAAFFA---------------------LQ-YLNGDA---------------------------SHMQEVLKGSHIPPDMRQKYR-KWVSPDNIPEKFKVRGVKPL-NPTDFMA--EVYETVKRFCEPNLCP----LL-AE-------------------------------------------------D--AVV-----------------------------------------------HQ----LP---------------------------E-------------------------SF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----CEYD---VLRD--DGL-----------LYK-KR-L-----EDN-----------------GVRV--------------------TWCHL--ED-------------G------------------------------------FHG--IISLYD---------------------------------------------------------- 518
519 -----------------------------DTRFGGVPVRLYLPRVPSAAL---------------------RP-A-TIF----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWI-----Y---------C--SIDS---HDNICRY---IARESG-SVV-VS------V-G---YR-LA----PE-----------------------------------HKY---PAAYED--CLNA----------------------------------------------T-----------------------------V--HFMRN-A-------------------------------------EHYG---V-------DPA--------------------------------------------------------C----I-SV--C-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------A--VSQ----TLSGRADLP------------RLR------AQILI---Y-----PGLQ-AV-----------------DM-------DLPSYQQNRGV-----PLLLRERAAFFA---------------------LQ-YLHGDA---------------------------SHKQDVLKGSHVPPEMRQKYK-QWVSPDNIPERFKARGYNPH-KTHDITA--EIFKKFERICEPNLCP----LL-AE-------------------------------------------------D--AVI-----------------------------------------------QQ----LP---------------------------E-------------------------SF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----CEYD---VLRD--DGL-----------LYK-KR-L-----EDN-----------------GVPV--------------------TWCHL--ED-------------G------------------------------------FHA--IISLYD---------------------------------------------------------- 519
520 --------------------REDKRLVIKDLIFEKVQVRLYQPKTSTTGQ---------------------RR-G-VLY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------VGR-----F---------G--SIRA---YERTCRY---LARKTN-SVV-VS------V-G---YR-LA----PE-----------------------------------YPY---PTQFHD--CLTA----------------------------------------------T-----------------------------I--HFMKT-A-------------------------------------QDYG---V-------DPA--------------------------------------------------------R----I-IV--C-G--DS-----------------SG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-LTA---------------------------------------------------------------------------------------------A--VAQ----ALVNRKDIP------------KLR------AQILI---Y-----PFLQ-AA-----------------DF-------NLPSYQQNARI-----PVLIRERTLILG---------------------LK-YLNKDL---------------------------SAVNTLLEGSHISAKGRQKYQ-KWLSVDNIPHEFKTRGYIPPGPPAPYSE--ELYELAKPFLEPLFSP----LL-CE-------------------------------------------------D--SVI-----------------------------------------------AQ----LP---------------------------E-------------------------TF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----CEYD---VLRD--DGL-----------LYK-KR-L-----EDH-----------------GIKV--------------------TLCHL--EE-------------G------------------------------------FHG--TVFL------------------------------------------------------------ 520
521 -----------------------------DVKFGQIPVRIYQPKAPSAGR---------------------RK-G-LVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFV-----F---------G--SIQS---HENICRY---IARESE-SVV-AS------V-E---YR-LA----PE-----------------------------------HVY---PAALND--CLAA----------------------------------------------A-----------------------------T--HFLKA-A-------------------------------------NDFG---V-------DPT--------------------------------------------------------R----V-II--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LAA---------------------------------------------------------------------------------------------V--VCQ----TLATKPDLP------------KLR------AQILL---Y-----PGLQ-AL-----------------DF-------DLPSYHQNRAV-----PLLFRERSAFYI---------------------LQ-YLNGNA---------------------------AHLEEVLEGSHVPTNVRLQYR-KFLSAENIPKEFKTRGYMPV-VHVTGDD--DISEGLSSLSSPECSP----LV-AE-------------------------------------------------D--VAL-----------------------------------------------RR----LP---------------------------E-------------------------TF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----CEYD---VLRD--DGL-----------LYK-KR-L-----EDN-----------------GVAV--------------------TWYHV--SN-------------G------------------------------------FHG--ILNFFD---------------------------------------------------------- 521
522 --------------------RKDPSLFVKDTYFNTVPVRVYQPKVSPSGP---------------------RK-G-VLF----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GGT-----F---------G--SIDS---YESVCSY---MARESD-AVV-VS------V-G---YR-LA----PE-----------------------------------HHY---PAQWND--CTTA----------------------------------------------A-----------------------------E--YFLKN-A-------------------------------------EGFG---V-------DPT--------------------------------------------------------C----I-VL--S-G--DS-----------------IG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-MTA---------------------------------------------------------------------------------------------F--LAQ----ELSKRKDLP------------KPR------AQVLV---S-----PFLQ-GL-----------------DF-------NLLSYQENRWV-----PFVSQSDFLHLL---------------------FI-YISKNM---------------------------SAVEIALAESHIPEEKRTKYQ-RWLNADNVPKELKAKGFYQE-FQLSSCPLDNIHTLIKTITGTNISP----LI-AD-------------------------------------------------D--AVI-----------------------------------------------QQ----LP---------------------------D-------------------------TF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----CEYD---VLRD--DGL-----------LYK-KR-L-----EDN-----------------GVKV--------------------SWCHL--KE-------------G------------------------------------FH------------------------------------------------------------------- 522
523 --------------------RLHPGLSTEDLCFDGVPVRIYRPKAPSAGW---------------------RK-G-FVF----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------AGM-----M---------G--SIDY---YQDVCSK---LAKDSQ-TVL-VS------V-G---YR-LS----PE-----------------------------------HPY---PTQCED--CFAA----------------------------------------------T-----------------------------V--HFMKN-S-------------------------------------EVFG---V-------DPS--------------------------------------------------------Q----I-VI--G-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-YAS---------------------------------------------------------------------------------------------V--IAQ----KLVERPDLP------------RLR------AQVLL---Y-----AGTQ-AM-----------------DF-------NLPSYQQNATM-----PLLFQDSVVFYG---------------------LK-YFGKST---------------------------SLTEDLLIGSHVPDEIRLKCD-KWMRPENLPERFLRRGFRQI-PAVPCKP--EVYEKLPEILSISFSS----LF-AD-------------------------------------------------D--AVI-----------------------------------------------RQ----LP---------------------------E-------------------------TF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-T-----CEYD---VLRD--DSL-----------LYK-KR-L-----EDN-----------------GVKV--------------------SWFHS--EN-------------G------------------------------------FHG--VINCID---------------------------------------------------------- 523
524 ------------------------NLYTKDLDFDGVAVRIYLHKTPSPVG---------------------RK-G-FVF----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------AGL-----A---------G--SISS---YQNICNR---LANESG-SVV-VS------V-G---YR-LS----PE-----------------------------------YPF---PAQSED--CHAA----------------------------------------------T-----------------------------V--HFMKN-A-------------------------------------EVYG---V-------DPS--------------------------------------------------------Q----I-VI--G-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-FAT---------------------------------------------------------------------------------------------M--IAQ----KLAGRSDLP------------KLR------AQVLI---Y-----AGVQ-AM-----------------DF-------TLPSYQQNARM-----PFLFRENLAYYG---------------------LQ-ALGKDP---------------------------SLSGDMLRGSHVPHEMRLKYE-KYVSPDNLPERFKRRGYRPV-PPSPFKP--EAYEQLSDILDASFST----LF-AD-------------------------------------------------D--AVI-----------------------------------------------RQ----LP---------------------------E-------------------------TF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-S-----CEYD---ILRD--DSL-----------LYK-KR-L-----EDN-----------------GVKV--------------------GWFHA--EN-------------G------------------------------------FHG--VINFFD---------------------------------------------------------- 524
525 --------------------RRASELLIKDLHFGEVPVRIYLPRSPSASK---------------------RR-G-VVL----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------CGM-----Y---------G--SIRS---HERICQQ---IAKKSD-SVV-VS------V-G---YR-LS----PE-----------------------------------HRY---PTQSLD--CVNA----------------------------------------------T-----------------------------I--HFLKT-A-------------------------------------KSYG---V-------DPH--------------------------------------------------------R----V-IL--C-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-FAT---------------------------------------------------------------------------------------------G--TCQ----ELLNRADIP------------KIR------AQILI---Y-----PFLQ-AM-----------------NF-------NLPSHQKNAST-----GLLSLERTVCFI---------------------LM-YLRKDC---------------------------ALTKAILAGSHVPESMNLKYK-KWIHPDLIPEKFK-QDYKPP-LPASYTP--QVHEEMKEMFELRFSP----LL-AE-------------------------------------------------D--AVV-----------------------------------------------GR----LP---------------------------D-------------------------TC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-T-----CEHD---VLRD--DGL-----------LYK-KR-L-----EDN-----------------NVKV--------------------TWCHI--ED-------------G------------------------------------FHG--VL-------------------------------------------------------------- 525
526 ---------------------RDSNLLIKDLVVDEVPLRIYQPKWPPAGK---------------------RR-G-ILY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------AGT-----F---------G--SIRA---FERVCRY---IAKKCD-SVV-VS------V-G---YR-LA----PE-----------------------------------HPY---PGQYSD--CLNA----------------------------------------------T-----------------------------L--YFMRN-L-------------------------------------DEYH---V-------DPA--------------------------------------------------------L----I-IL--G-G--DS-----------------CG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-FAT---------------------------------------------------------------------------------------------V--ICQ----ILVNKRDLP------------KVR------AQILL---Y-----PGLQ-GL-----------------DF-------QLPSYQQNALI-----PILSRKLVIYFC---------------------FR-YLNRKP---------------------------SYLEDIIQNCHVPESMKWKYK-KWISADNIPDEFKIRGYKPQ-KLTSYKP--EVHEAVKEVLAMTFSP----LL-AE-------------------------------------------------D--AII-----------------------------------------------CQ----LP---------------------------E-------------------------SY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-T-----CEFD---VLRD--DGL-----------LYK-KR-L-----EDN-----------------GIRV--------------------TWYHS--EG-------------G------------------------------------FHG--ILAFF----------------------------------------------------------- 526
527 --------------------REDPHLSIKDLVLDGVPVRMYQPRRPFGGK---------------------RR-G-ILY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------IGQ-----F---------G--SVAA---YDRLCRR---IAKDSD-SIV-IS------V-E---YR-LA----PE-----------------------------------NPY---PTQFLD--CLKA----------------------------------------------T-----------------------------V--HFLKN-V-------------------------------------EDYG---V-------DPA--------------------------------------------------------S----V-II--S-G--DS-----------------IG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-LAS---------------------------------------------------------------------------------------------A--VCQ----GLVNRPDLP------------KVR------AQVLI---Y-----PFLQ-AV-----------------DF-------NLPSYQKNRHM-----PLFSQRLVVEFG---------------------LQ-YLQKDL---------------------------ALTEGALKGFHVPKEKKRKYG-RWLWPEKSAEEFEGEDDALT-WPKGTVD--EIFET-------TFSP----LL-AE-------------------------------------------------D--SVI-----------------------------------------------RQ----LP---------------------------E-------------------------AY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----CTSD---VFMD--DGH-----------LYK-KR-L-----EDN-----------------GRKV--------------------TWYQL--DD-------------G------------------------------------FHG--VLYFVD---------------------------------------------------------- 527
528 ---------------------KGPSLSTSDTHIEGVPVRLYRPK-PHRLS---------------------QR-G-IVF----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GGT-----S---------G--SIVS---YDVFCSY---LSKESD-SVV-LS------V-G---YH-LV----PY-----------------------------------QPY---PKQYYQ--CLDV----------------------------------------------A-----------------------------V--HFMKH-A-------------------------------------EEYG---V-------DPG--------------------------------------------------------R----V-IV--C-G--DS-----------------FG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LAA---------------------------------------------------------------------------------------------S--VCQ----MLVQKDDVP------------KPR------AQMLV---Y-----PFLQ-SV-----------------KH-------SLPSYMQNAHT-----PPLGRKELVTAA---------------------LK-YIQKNF---------------------------SLLEVIIQGDHISREVKAKYD-KWLSKENLPEEFRRRESKPR-TPNGFSF-GEIQELIDQLCGPLLSP----LL-VD-------------------------------------------------D--AVI-----------------------------------------------RQ----LP---------------------------D-------------------------TF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----CQFD---VLRD--DGV-----------LYK-KR-L-----EDN-----------------GVPV--------------------TWCHF--ED-------------A------------------------------------FHG--FLGFLNQR-------------------------------------------------------- 528
529 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y---IAEKTD-SVV-VC------I-G---FR-LA----PE-----------------------------------HPF---PIPVMD--CCTA----------------------------------------------T-----------------------------T--HFLKN-A-------------------------------------AEYG---V-------DPN--------------------------------------------------------C----I-AV--Y-G--ES-----------------SG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-FAT---------------------------------------------------------------------------------------------A--VCQ----HLATKKGLP------------KLR------GQVLV---H-----PFLQ-AF-----------------DF-------NLPSYQQNHSV-----PILFKKRALKMG---------------------MV-YLTGKR---------------------------IDVDGLMNNAHIPRHLWEKYR-KWVNPDFIPEQFKARGYVPV-EKAPFSP--ELYELCKTGDNPMFSP----LL-AE-------------------------------------------------D--DII-----------------------------------------------RQ----LP---------------------------E-------------------------TF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-T-----CEYD---TVRD--DGI-----------LYK-KR-L-----EDN-----------------GVPV--------------------TWHHI--ED-------------G------------------------------------FH------------------------------------------------------------------- 529
530 -------------------LRKNSALIIKDLLFDGVPVRVYWPKTESSGN---------------------RR-G-MVY----L-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------VGL-----F---------G--SIKA---YERVNRY---ISRRSD-SVV-VC------V-G---FR-LA----PE-----------------------------------HPF---PVPVLD--CCTA----------------------------------------------T-----------------------------I--HFLRN-A-------------------------------------TKYG---V-------DPN--------------------------------------------------------R----I-AV--C-G--DS-----------------SG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-FAA---------------------------------------------------------------------------------------------A--VCQ----HLATKKDLP------------KLR------AQILI---Y-----PFLQ-AV-----------------DF-------NLPSYQQNHSI-----PVLFKKRAIQLG---------------------VT-YLTGRL---------------------------AKVDGLMKNAHVPQDLLAKYK-KWVSADHIPDEFKARGYVPL-EPVPFCE--ELYELYKEGFQPMFSP----LL-AE-------------------------------------------------D--DVV-----------------------------------------------RR----LP---------------------------E-------------------------TF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----CEYD---VVRD--DGL-----------LYK-KR-L-----EDN-----------------GVPV--------------------TWHHV--KD-------------G------------------------------------FHG--MMFLID---------------------------------------------------------- 530
531 -------------------LKKSSKLTIKDLFFDEIPVRVYWPKTSSAGN---------------------RR-G-VVL----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------VGL-----F---------G--SIQA---YERVSRY---IARKSD-SVV-VS------V-E---FC-LA----PE-----------------------------------HLF---PAPVLD--CCTA----------------------------------------------T-----------------------------T--HFLKN-A-------------------------------------TKYG---V-------DPN--------------------------------------------------------R----I-VV--C-G--DS-----------------SG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-FAA---------------------------------------------------------------------------------------------A--VSQ----HLATKKDLP------------KLR------AQILL---Y-----PFLQ-VM-----------------DF-------NLPSYQQNHSV-----PPLFKKRAIKLG---------------------IT-YLTGKH---------------------------LNVDGCMRNAHVPPDMWVKYR-QWINPDYIPDEFKARGYVPM-EPDPFNQ--EVYEQFKEAGNIMFAP----LV-AE-------------------------------------------------D--DMI-----------------------------------------------RQ----LP---------------------------E-------------------------TF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-T-----CEYD---VLRD--DGL-----------LYK-KR-L-----EDN-----------------GVPV--------------------TWHHI--KD-------------G------------------------------------FHG--IMFFID---------------------------------------------------------- 531
532 ----------------------DSGLVIKDLRFDGVPVRMYQSKSRPSEK---------------------SR-A-IVY----I-------P---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------VGL-----L---------G--SISA---YERVCRY---IARESG-FVV-VS------V-G---YR-LA----PE-----------------------------------HLY---PVPLLD--CCTA----------------------------------------------V-----------------------------I--HFLKH-A-------------------------------------ADYG---V-------DPD--------------------------------------------------------H----V-TV--G-G--DS-----------------SG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-FAT---------------------------------------------------------------------------------------------A--VCQ----RLTARKDLP------------RIR------AQALL---Y-----PFLQ-AV-----------------DF-------NLPSYQQNCSI-----PPLFKKRAVKLG---------------------LM-YLMGTS---------------------------EHVGYLMKNAHMTRDLQAKYQ-KWISADHIPDEFKARGYVPA-EPSPFCE--ALPPFCTKGLDPMFSP----LL-AE-------------------------------------------------D--ETL-----------------------------------------------RQ----LP---------------------------E-------------------------AF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-T-----CEYD---VVRD--DGL-----------LYK-KR-L-----EDN-----------------GVPV--------------------TWCHV--KD-------------G------------------------------------FH------------------------------------------------------------------- 532
533 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YERMSRY---IARESN-TVV-VN------V-G---FR-LA----PE-----------------------------------HPC---PAQIQD--CCVA----------------------------------------------T-----------------------------E--HFLKN-A-------------------------------------ADYG---V-------DPA--------------------------------------------------------R----I-SI--G-G--ES-----------------SG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-FSA---------------------------------------------------------------------------------------------A--VCQ----VLAGKRLLP------------KLR------AQILL---Y-----PYLQ-AV-----------------DF-------NLPSYQQNGSV-----PPLFRKFTLTHG---------------------TM-YLTGKA---------------------------IDVEGIISGNHIPEDLRAKYS-KWVSADHVPDEFKARGYRPV-EPAPFSN--EQYESLKKGLDSLFSP----LL-AE-------------------------------------------------D--NVI-----------------------------------------------RQ----LP---------------------------E-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-T-----SEYD---ILRD--DGI-----------LYR-KR-L-----LDN-----------------GVPV--------------------TWHHI--ED-------------S------------------------------------VHG------------------------------------------------------------------ 533
534 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T---YELLCRF---LARESD-SVV-VF------L-D---FR-LA----PE-----------------------------------HQH---PAQLTD--CLTG----------------------------------------------T-----------------------------L--YFMNH-A-------------------------------------KNYG---V-------DPN--------------------------------------------------------R----I-IL--I-G--ES-----------------SG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-LVS---------------------------------------------------------------------------------------------T--ICR----ELVKKMHVP------------KVR------AQILL---Y-----PFLQ-IL-----------------DL-------SLPAHQQNQFG-----PALTMRRAAKLA---------------------FT-FLDEKL---------------------------DNVDDMLNNAHIPEIMRMQFK-KWISADLIPEKFKARGYKPP-PPVPFSK--ELYEKVRLYDKTMSSP----IQ-DV-------------------------------------------------D--AII-----------------------------------------------QQ----LP---------------------------E-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----CEYD---IFRD--DGL-----------LYK-KR-L-----EDN-----------------GVRV--------------------TWNHL--ED-------------G------------------------------------FHG--VALFID---------------------------------------------------------- 534
535 -------------------VKRDARLVVTDLYLGTTPVRLFQPKAASPSP---------------------RR-G-IIF----F-------P---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GGF-----L---------G--SLDS---YHNLCSQ---LAVETD-SVL-LL------I-G---YR-KL----PD-----------------------------------HHY---PCIFQD--CLNT----------------------------------------------S-----------------------------I--LFLKG-L-------------------------------------KTYG---V-------DPS--------------------------------------------------------R----V-VI--C-G--DS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-NVA---------------------------------------------------------------------------------------------C--VIQ----HLVGRSDLP------------RIR------AQVLI---Y-----PITQ-VI-----------------NL-------QLPSHQQNRNV-----PFLSQKIMMICM---------------------LK-YLVVNF---------------------------HWWDTILRGAFIPPDIWRKYS-KWLSSDNIPKSFRKPGYQPE-FHGPFNE--AAYLENKHLFDITNAP----LL-GD-------------------------------------------------D--EVI-----------------------------------------------AQ----LP---------------------------E-------------------------AF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-S-----CEND---VFRD--DTL-----------LYM-KR-L-----KDQ-----------------GVPV--------------------MWYHV--ED-------------G------------------------------------FHG--SL-------------------------------------------------------------- 535
536 -------------------IRKNSNVAVTDMHFGTVPVRLFKPKEASSKY---------------------RR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DT---YHGLGSF---LAHETD-SLV-LL------V-G---YR-KL----PD-----------------------------------YHH---PVPFKD--CLNA----------------------------------------------T-----------------------------I--YFLKN-L-------------------------------------EILG---V-------DPS--------------------------------------------------------R----V-VL--C-G--DS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------W-AVA---------------------------------------------------------------------------------------------T--VTQ----VLTSMPNLP------------RIQ------TQVLI---Y-----PILH-FI-----------------NF-------QLPSYQQNKNV-----PFLTRDMLLMCV---------------------CK-YLAIDL---------------------------SWTDAMSTGAVIPLDKWKKYR-KWLSYDNIPRRFWRQDTQPE-VLGPFNE--AAYLETKHVWNAEISP----LL-AD-------------------------------------------------D--KII-----------------------------------------------AQ----LP---------------------------K-------------------------TF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-S-----CEHD---VLRD--DAL-----------LYK-RR-L-----EDQ-----------------GIPV--------------------SWYHA--ED-------------G------------------------------------FHA--CINLFDKQ-------------------------------------------------------- 536
537 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKKSG-SVV-LS------V-G---YR-RL----PQ-----------------------------------HKF---PVAARD--CIAA----------------------------------------------T-----------------------------I--HFLKS-L-------------------------------------NVYG---V-------DPD--------------------------------------------------------R----V-VV--C-G--DS-----------------VG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-VAT---------------------------------------------------------------------------------------------I--VCQ----KLLDCPDLP------------KIR------AQILV---Y-----AILQ-AV-----------------DF-------QSPSYQQNRNI-----PLLNWNFAFYCW---------------------SC-YLDINP---------------------------SWKSTIMKGAHLPAEVWEKYR-KWLGAENIPERFKKKSYRPM-PREPLNE--AAYLETNLALDLMNSP----LI-AE-------------------------------------------------D--EVM-----------------------------------------------SQ----LP---------------------------E-------------------------AC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-S-----CEYD---LLRD--HSL-----------LFK-KR-L-----EDL-----------------GVPV--------------------TWHHM--ED-------------G------------------------------------FHG--VLSTFDMGYLQFPCSTRILNA------------------------------------------- 537
538 -------------------LKEDPDVVVTDLLFGTVPVKLYQPKGLSCTP---------------------RP-G-IVF----Y-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GAV-----M---------G--SLKT---HYAICCH---LCKKSG-SVV-LA------V-G---YR-KL----PQ-----------------------------------HKF---PAALTD--CFAA----------------------------------------------T-----------------------------T--HFLKS-L-------------------------------------NVYG---V-------DPD--------------------------------------------------------R----V-VV--C-G--DS-----------------VG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-VAT---------------------------------------------------------------------------------------------V--VCQ----KFLGCPDLP------------KIR------AQILI---Y-----AQLQ-AV-----------------HF-------QLPSYQQNKNV-----PLASRDFAFYCW---------------------HR-YLDIKP---------------------------SWKSTVLKGAHLPAEVWEKYR-KWLGTENIPERFKKRPYRPV-LPEPLNE--AAYLETSLALDLLNSP----LI-AE-------------------------------------------------D--EVI-----------------------------------------------SQ----LP---------------------------E-------------------------AC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-S-----CEYD---LLRD--DSL-----------LYK-KR-L-----EDL-----------------GVPV--------------------TWYHM--ED-------------G------------------------------------FHG--VLSTLD---------------------------------------------------------- 538
539 ------------------PLKKDPDVRVTDLRYGTIPVRLYQPKASSCTL---------------------RR-G-IVF----Y-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GGI-----L---------G--SLNT---HHSICCH---LSKESD-AVL-LA------V-G---YR-KL----PQ-----------------------------------HKS---PVPIRD--CLAA----------------------------------------------T-----------------------------I--RFLKS-L-------------------------------------KTYG---V-------DPA--------------------------------------------------------R----V-VV--C-G--ES-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-AAA---------------------------------------------------------------------------------------------I--ICQ----NLVDSPDLP------------KIR------AQILI---Y-----PTLQ-CL-----------------DF-------QSPSYQQNKNI-----PLLSLSFLFYCL---------------------CS-YLDISP---------------------------SWKSTVLKGAHLPAEVWEKYR-KWIGVENIPERFKKRGYRWM-PREPLNE--DAYQEAKFMLDLANSP----LL-AE-------------------------------------------------D--EVV-----------------------------------------------FR----LP---------------------------E-------------------------AC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-S-----CEYD---LLRD--HSL-----------LYK-KR-L-----EDL-----------------RVPV--------------------TWHHM--ED-------------G------------------------------------FHG--VFATFD---------------------------------------------------------- 539
540 -----------------TLFERH-LVRVTDATWNGVHVRTYEPRLVE-NST--------------------DG-A-VIF----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFA------------------IGSVAM-YDSLTRR---MAKSMN-TFV-VS------I-D---YR-LS----PE-----------------------------------TVF---PENLLD--CEKA----------------------------------------------I-----------------------------D--YFLEN-S-L-----------------------------------EKFK---I-------DPK--------------------------------------------------------K----V-IL--V-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAT---------------------------------------------------------------------------------------------A--IAQ----RRAEKGAEP------------KLL------AQVLL---Y-----PLLQ-LV-----------------DL-------QMTSYRYFHKRLTGI-AFVDPASVAFYY---------------------ML-YAGIPL--------EKAKELVPIVLTNG-------HVKPDYRE--KIDKLLTYR-TTIEST----HTYNT-TKIPKRWEIVENSEAQNLLEKVIFDPNFSP----IM-RE-------------------------------------------------N----L-----------------------------------------------EN----LP---------------------------K-------------------------SL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-T-----CEYD---VLRD--EGL-----------IYS-ER-L-----MAS-----------------GVPT--------------------KLINY--KN-------------G------------------------------------YHA--MLNMHNEITEASTCLDDVMH-------------------------------------------- 540
541 --------------------NTHGQVDIKWHKWNETPVKVYRPTNNK-TST--------------------DG-A-VLF----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFA------------------LGNVDM-YDSLVKR---MAYEMK-TLF-IS------I-E---YR-LS----PE-----------------------------------TVF---PGGILD--CEAA----------------------------------------------I-----------------------------D--HFFDF-G-A-----------------------------------VQFG---V-------NTS--------------------------------------------------------K----V-VI--M-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAT---------------------------------------------------------------------------------------------V--IAQ----RRAARNSFP------------KLA------GQVLI---Y-----PLLQ-MA-----------------DM-------QTVSYRYFHSRLRGY-ALVDPESVAYYY---------------------MF-YAGIDM--------DEKAYLVPSVISNG-------HVANHLQS--EASEIMSYK-SVIEMK----HNYKN-HSITERWEVSQSYEAQDLMEPFLTNPDFSP----LM-RK-------------------------------------------------D----L-----------------------------------------------SN----LP---------------------------P-------------------------TM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI-T-----CEFD---ILRD--EGL-----------IYG-ER-L-----KVS-----------------GVPT--------------------TTIHY--EN-------------G------------------------------------FHA--MLNFHSELDEASKSVDDIEQ-------------------------------------------- 541
542 ------------------------------TYFDGVKVRVYEPIMRK-EGL--------------------QP-G-VIF----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GMA-----T---------G--SPDS---YDGLTRT---MAERLD-IFL-VS------I-D---YR-LA----PE-----------------------------------YPF---PSGFND--NLRA----------------------------------------------T-----------------------------T--WLLKN-A-------------------------------------HIFD---L-------DAR--------------------------------------------------------R----V-AI--T-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-FAA---------------------------------------------------------------------------------------------G--VSQ----AIHDDVTLP------------NLK------LQVLL---Y-----PGLQ-QL-----------------DF-------HSHSYQKYEAEFGNG-GALTRERVSDFI---------------------SL-Y-------------------LHGKIDPAMVHRSVHNHHVSQDLLDTSPVFKYVD-RDHIPKEMRVSEKHTKQREEMERRS-GSDEVWNHVQEYYLDPRFAP----IV---------------------------------------------------------------------------------------------------------REDLGGLP---------------------------H-------------------------AM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IT-T-----CGFD---CLRD--DGV-----------HYA-RR-L-----SDA-----------------GVGV--------------------HYKDY--ES-------------A------------------------------------FHG--VIWATKNVQFEVG--------------------------------------------------- 542
543 -----------------------SNIRSNVTTFDGVRVRLYEPIKKE-DFL--------------------QP-A-LIF----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GNA-----L---------G--SPDG---YDRLTRL---IAERLN-VVV-VS------I-D---YR-LS----PE-----------------------------------HLF---PAGHLD--CLRA----------------------------------------------T-----------------------------S--WFLRN-AD------------------------------------QDFS---V-------DTS--------------------------------------------------------R----V-AI--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LSA---------------------------------------------------------------------------------------------T--VSQ----AIHDDQTLP------------NLK------LQILI---Y-----PVTQ-SL-----------------DL-------LTPSYQKYDQDFGDE-GVLPRKRVAAFT---------------------SM-H-------------------HLGRSDPLYMQQILSNEHIIEEFRLNSPYLRYVD-HDVIPTELR---KETRLYLPPRQGP-GNESLWNQIEGTYLDPRWSP----LL---------------------------------------------------------------------------------------------------------REDLSGLP---------------------------Q-------------------------AF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-T-----CGFD---SIRD--DGI-----------FYA-KR-L-----EAA-----------------GVKT--------------------KWKHY--PS-------------A------------------------------------FHG--VMFLSNF--------------------------------------------------------- 543
544 -------------------------------DLGGVKARLYEPIKRSGSDL--------------------MP-A-FIY----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GMC-----I---------G--SADA---YDGLTRS---LAEELD-TVV-VS------I-D---YR-LA----PE-----------------------------------HPF---PIGHED--CVAA----------------------------------------------T-----------------------------R--YFMQH-AE------------------------------------NDYH---V-------DQR--------------------------------------------------------R----I-GV--G-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LSA---------------------------------------------------------------------------------------------S--VAN----DIHDDPSLP------------DLK------LQVLI---Y-----PSMQ-KI-----------------DL-------NTPSYQKYTADFGGS-GILPLHLGISFS---------------------NL-A-------------------SVGKIDQEFMKNAAKNNHTSSEFKKTSLEYKYVD-HNQIPAEFR-DPRYYKTRNDPQ--T-GDAALWERISHILLDARSAP----LM---------------------------------------------------------------------------------------------------------RHDLTGVP---------------------------P-------------------------AY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI-T-----CGFD---SLRD--DGI-----------FYK-NR-L-----EEA-----------------GVAV--------------------TWSHY--EG-------------A------------------------------------FHG--ILWLSSAVRFTLGENMR----------------------------------------------- 544
545 -------------------------------DFDGVAVRFYEPISRERND---------------------LP-G-LIF----M-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFM------------------FGSAGM-YDPITRK---IAEVIG-GVV-VS------V-D---YR-LA----PE-----------------------------------HPF---PAGFDD--CLTA----------------------------------------------S-----------------------------K--HFFKH-C-------------------------------------KEFG---V-------DPT--------------------------------------------------------R----V-AI--C-G--DS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------G--VVQ----ELC-DKTNAARGMC-------RPK------LQILL---Y-----PLLQ-ML-----------------DL-------KTPSYQRHDAAFGISGGFMPTTSIGWMT---------------------PR-YL----------TGQKDGSLTKALLKGA-------LHSYAAQENDVLKDTLT-H-DCVPAE-LKCEAYAT-PSVTDHDPSF--KEIWDRFKPLVLDNTIMP----LY-KE-------------------------------------------------D----L-----------------------------------------------GR----LP---------------------------P-------------------------AY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-T-----CDFD---VLRD--DGT-----------MYA-ER-L-----KQA-----------------GVEA--------------------VLENC--KG-------------A------------------------------------LHG--LLFF------------------------------------------------------------ 545
546 ---------------------SGSNIRSKVMNFDGVTVRLYEPIERK-EEA--------------------TP-A-MVF----M-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GLA-----F---------A--NIDV---YDRLTRQ---MAEKLD-IVL-VS------V-E---YR-KI----PE-----------------------------------YQF---PAQIED--SMKA----------------------------------------------T-----------------------------R--YLLTH-A-------------------------------------SDFK---V-------DAS--------------------------------------------------------R----V-AV--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LAT---------------------------------------------------------------------------------------------V--IAQ----QVYDDPDLP------------NIK------VQVLF---Y-----PGTQ-MY-----------------DF-------QTPSHQKCSALFGND-GMLTHQTLAWLG---------------------SM-Y-------------------HFGKADFEFMGQVMSNNHTAPSFKQTKRYQKNIN-HSLIPKELI--PDFY---QPPPNNT-GSDVLWEKIRDVYMDPRHDP----LM---------------------------------------------------------------------------------------------------------RDDLRGMP---------------------------D-------------------------SF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IA-T-----CGFD---CIRD--DGI-----------MYA-KR-L-----EQA-----------------GNHV--------------------EWVNY--NG-------------C------------------------------------FHG--VLW-QGWINFKNG--------------------------------------------------- 546
547 -------------------------VTLDDTTFDGVRVLFYQRTDGS-QEK--------------------RP-A-FIY----L-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GLT-----I---------G--SVDI---FEIGTRE---IAGHLDGMVV-IS------V-D---YR-LA----PK-----------------------------------HPF---PAAYDD--GLAV----------------------------------------------T-----------------------------K--WLMRH-A-------------------------------------DVYG---V-------DPT--------------------------------------------------------R----I-AV--G-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LTA---------------------------------------------------------------------------------------------A--IVQ----AIHDDPTLP------------NVR------LQVHL---F-----PWLQ-HF-----------------DY-------QTPSYQKNAHVFGEK-TWLENSIPGFCF---------------------SA-Y-------------------FNGVLNDSLVEQMTTNNHTSAAFKNSPLYRKIFN-HSLIPKDFR-DPAHY---TPPQSSDFGNEAIWNELKDVVLDTRFSP----IL---------------------------------------------------------------------------------------------------------REDMRGLP---------------------------K-------------------------AY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IA-T-----CGYD---PLRD--DGI-----------FYF-HR-L-----KDA-----------------GVDV--------------------FWVNY--DA-------------A------------------------------------FHG------------------------------------------------------------------ 547
548 ----------------------------WENMKDALTSTKYSPLYREDFSK--------------------LPRA-FVA----T-------F---------------------------------------------------------G----------------------------------------------------------------------------------------------------------------------------------YDCLRDDGIFYAKRLE-NAG-VP------V-K---YR-LA----PK-----------------------------------HVF---PAAFDD--AFAA----------------------------------------------T-----------------------------K--WFLSH-A-------------------------------------DEFG---V-------DPT--------------------------------------------------------R----V-AL--I-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LAA---------------------------------------------------------------------------------------------L--VSG----AISDEPSLP------------DIK------LQVLI---Y-----PWLQ-SF-----------------DH-------NTPSMQKIR---------------------------------------------------------------CQXRVDEHLGQQIYANNHTSAAFKQSEFYQKHLS-HDLIPADMK------PDCYVPPTSDFGDDELWKNMKDALTSTKYSP----LY---------------------------------------------------------------------------------------------------------REDFSKLP---------------------------R-------------------------AF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VA-T-----FGYD---CLRD--DGI-----------FYA-KR-L-----EYA-----------------GVPV--------------------KWVNY--ED-------------G------------------------------------FHG--ITWFGDN--------------------------------------------------------- 548
549 ------------------------NLTARYAHFDGIRVLIYEPVHRP-NAL--------------------IP-A-LVY----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GYA-----L---------G--STKL---HGALTKH---LAESLN-MVL-VS------V-E---YR-LA----PE-----------------------------------HPL---PAGPDD--GVIA----------------------------------------------T-----------------------------K--YLLQH-A-------------------------------------CEFG---I-------DPH--------------------------------------------------------R----I-TV--A-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LAA---------------------------------------------------------------------------------------------V--VTQ----QIHDDPSVP------------DLK------LQVLF---Y-----PWLQ-AM-----------------DF-------YTPSYQLYDHTYGNI-GL-SRSKVVGFV---------------------AY-N-------------------LFQRLDAEFEIKVMRNMHMSADFKRS--HRFLF-----------------------------------------LDSGMSP----LF---------------------------------------------------------------------------------------------------------REDTSGLP---------------------------K-------------------------AF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IA-T-----ADQD---ILRD--DGI-----------FYT-HA-L-----EQG-----------------GVEV--------------------HWKNY--QG-------------A------------------------------------WHG------------------------------------------------------------------ 549
550 -----------------------SNVKAQYAEFEGVRVLVYTPLTER-RGL--------------------AP-G-LVY----Y-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFG-----F---------A--STKT---NGRLTRY---LAEQLD-MVV-IS------V-D---YH-LA----PA-----------------------------------HPF---PAAVED--SFTA----------------------------------------------T-----------------------------K--WFLDH-A-------------------------------------HEYG---V-------DAD--------------------------------------------------------R----V-VV--S-G--DS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTA---------------------------------------------------------------------------------------------V--IVQ----LVHDDPSLP------------EIK------LQVLF---Y-----PWTQ-CF-----------------DF-------NTPSYQKYEVDFGET-GMVAKPRMAEFV---------------------SA-Y-------------------LLGRFDKPFMKQLQKNEHVSAAFKQSKLYRAVFN-HAIIRQHPGVPSTSLPSQQKIFQG--GNDTLWEDIKDRLLDPRLSP----LF---------------------------------------------------------------------------------------------------------RKDFKGLP---------------------------A-------------------------AF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IA-T-----ADLD---SLRD--DGI-----------FYA-RL-L-----AEA-----------------GVEV--------------------TLKNY--LG-------------A------------------------------------YHG--IAAAGPITNIPTGVQMLN---------------------------------------------- 550
551 -------------------------------------LRIYRPKSNHES----------------------LP-V-LLW----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GYI-----L---------G--SIDD---NDDTCMR---FAKEAG-CVV-VS------V-D---YR-LA----PE-----------------------------------HPY---PAPIED--CYSA----------------------------------------------L-----------------------------K--WIA----------------------------------DN------AKS---L-------NID------------------------------------------------------SNR----I-GV--A-G--VS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-LTA---------------------------------------------------------------------------------------------A--LSLLARDRKYP-----------------SIC------LQMPL---Y-----PMID-DR-----------------N--------DTPSANEIKEGF----VWNQK-ANEAGW---------------------KM-YLGEMY------------------------------------------------------------------------------------GTDQIPAYAAP-------SR-------------------------------------------------A-----------------------------------------------------EDYSDLP---------------------------Y-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TF-V-----GQLD---PFRS--ETL-----------TYV-SK-L-----AQA-----------------GVDV--------------------EFHLY--PN-------------A------------------------------------YHW--FEGLN--PNADVS--------------------------------------------------- 551
552 -------------------------------------LRIYRPKSNHES----------------------LP-V-LLW----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GYI-----L---------G--SIDD---NDDTCMR---FAKEAS-CVV-VS------V-D---YR-LA----PE-----------------------------------HPY---PAPIED--CYSA----------------------------------------------L-----------------------------K--WIA----------------------------------DN------AKS---L-------NID------------------------------------------------------SNR----I-GV--A-G--VS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-LTA---------------------------------------------------------------------------------------------A--LSLLARDRKYP-----------------SIC------LQMPL---Y-----PMID-DR-----------------N--------NTPSANEIKEGF----VWNQR-ANEAGW---------------------KM-YLGEMY------------------------------------------------------------------------------------GMDQIPAYAAP-------SR-------------------------------------------------A-----------------------------------------------------EDYSDLP---------------------------Y-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TF-V-----GQLD---PFRS--ETL-----------TYV-SK-L-----AQA-----------------GVDV--------------------EFHLY--PN-------------A------------------------------------YHW--FEGLN--PNADVS--------------------------------------------------- 552
553 -------------------------------------LKIYRPKSNNES----------------------LP-A-LLW----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GYI-----L---------G--SIND---NDDLAVK---IAKEAN-CMV-VS------V-D---YR-LA----PE-----------------------------------HPY---PAPIED--CYAA----------------------------------------------L-----------------------------K--WIA----------------------------------DN------AET---L-------NID------------------------------------------------------SNR----I-GV--A-G--VS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-LTA---------------------------------------------------------------------------------------------A--LTLLARDRQYP-----------------SIC------FQMPL---Y-----PMID-DR-----------------N--------NTPSANEIKEGF----VWNQK-SNEAGW---------------------KM-YLGELH------------------------------------------------------------------------------------GTDHIPAYAAA-------AR-------------------------------------------------A-----------------------------------------------------EDYRNLP---------------------------R-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TC-V-----GQLD---PFRS--ETL-----------TYV-TK-L-----AEA-----------------GVDV--------------------EFHLY--PG-------------A------------------------------------YHG--FEMMH--PDTDIS--------------------------------------------------- 553
554 -------------------------------------VRIYEPTKKTKA----------------------LP-G-VLW----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GYQ-----V---------G--SPEM---DDKLCEK---FVLEAN-CIV-VS------V-D---YR-LA----PE-----------------------------------NPF---PAPLED--CYAA----------------------------------------------L-----------------------------Q--WVS----------------------------------NN------SED---L-------GVD------------------------------------------------------SSR----I-AI--A-G--MS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-LTA---------------------------------------------------------------------------------------------A--LALLARDRKGP-----------------SII------FQMPL---C-----PMID-DR-----------------N--------IKPSAFEITDSK----LWNRK-TNISGW---------------------KM-YLGSVY------------------------------------------------------------------------------------G-EEVSPYAAP-------AR-------------------------------------------------A-----------------------------------------------------TDLTGLP---------------------------P-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TM-V-----GEID---LFRD--ETI-----------EYA-NR-L-----MQA-----------------GVPT--------------------EFHVY--PG-------------G------------------------------------YHG--FELIV--PNAEIS--------------------------------------------------- 554
555 --------------------------IPGPPGAPAVPVFVYLPRQRQGV----------------------TP-A-LFY----T-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFI-----A---------H--SAAF---YHRVCSG---YAAALG-VPV-IS------P-D---YR-LA----PE-----------------------------------TPF---PGPLED--VYAA----------------------------------------------L-----------------------------K--WTF----------------------------------TQ------AAP---L-------SID------------------------------------------------------PER----V-AL--A-G--ES-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-LTA---------------------------------------------------------------------------------------------C--LAQLAHDRGEV-----------------RPA------FQALI---C-----PMLD-ER-----------------T--------VLKTDWQGRGEF----VWTPT-SNLTGW---------------------SS-YLGFRP------------------------------------------------------------------------------------GTQTPPPYAVA-------AR-------------------------------------------------R-----------------------------------------------------EDLSGLP---------------------------P-------------------------AW--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IG-T-----SDLD---LFYD--ENR-----------EYA-RR-L-----MAA-----------------GVPC--------------------EWAEV--AG-------------G------------------------------------YHG--FHLLK--PEAEASRQFNTSFLS------------------------------------------ 555
556 ----------------------------------------------------------------------------IVH----F-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GHV-----T---------A--DRFV---GLNTLFD---IIEKLG-AVV-VS------A-E---YR-LA----PE-----------------------------------HPQ---PAQVED--SYAA----------------------------------------------L-----------------------------R--WAH----------------------------------SH------ASE---L-------GFN------------------------------------------------------PDK----L-VT--C-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LTA---------------------------------------------------------------------------------------------G--VSLLARDRAGP-----------------KLL------GQMLF---Y-----PWVD-DA-----------------T--------TSHSIEQFGDVA----PWTKD-DNAYGL---------------------DL-ALGK--------------------------------------------------------------------------------------NREYASIYSLP-------AR-------------------------------------------------A--AET-----------------------------------------------QQGLSGLP---------------------------P-------------------------TY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LD-V-----GEAD---VFRD--QDM-----------EFA-GN-L-----WKA-----------------GVQT--------------------ELHVW--PG-------------A------------------------------------WHA--FDTFA--P-------------------------------------------------------- 556
557 ------------------------------------------------------------------------P-G-VLH----I-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GLA-----T---------G--NRFL---GF-TMLN---WVEELG-AVI-VT------A-E---YR-LT----PE-----------------------------------HPQ---PAALED--SYAA----------------------------------------------L-----------------------------E--YMA----------------------------------AH------SEE---L-------GFN------------------------------------------------------AEK----L-IV--A-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAA---------------------------------------------------------------------------------------------G--ITLLARDRQGP-----------------RIA------GQVLM---Y-----PWVD-DS-----------------M--------ASASITQFGDIA----PVKKG-NLATVN---------------------DY-AFGK--------------------------------------------------------------------------------------NREFADMYTAP-------AR-------------------------------------------------A-----------------------------------------------------KSLNGLP---------------------------P-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ID-V-----GEAD---VFRD--QDV-----------EYA-TR-L-----WRD-----------------GVTT--------------------ELHVW--PG-------------A------------------------------------YHG--FDVFV--P-------------------------------------------------------- 557
558 -------------------DVETSTETILGVDGNEITLHVFRPAGVEGV----------------------LP-G-LVY----T-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GMT-----I------------LTTDNRVHRRWCTD---LAAAG--SVV-VM------V-D---FR-NAWTAEGH-----------------------------------HPF---PSGVED--CLAA----------------------------------------------V-----------------------------L--WVDEH-R-------------------------------------ESLG---L-------S----------------------------------------------------------G----V-VV--Q-G--ES-----------------GG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAI---------------------------------------------------------------------------------------------A--TTLLAKRRG-------------------RLDAIDGVYASI-----------PYISGGY-----------------AWDHERRLTELPSLVENDG------YFIENGGMALLV---------------------RA-YDPTGE--------------------------------------------------------------------------------------HAEDPIAWP----YF-AS-------------------------------------------------E--DEL-----------------------------------------------RG----LP---------------------------P-------------------------FV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VA-V-----NELD---PLRD--EGI-----------AFA-RR-L-----ARA-----------------GVDV--------------------AARVN--IG-------------L------------------------------------VHGADVIFRHWLPAAL----------------------------------------------------- 558
559 -----------------PLP-DLSVQAEDKIL-GGVPTRIYTPP------DVADP------------------PL-ALY----F-------H---------------------------------------------------------A--------------------G---------------------------------------------------------------------------------GWV-----M---------G--SIDE---EDGFVRT---LCKLAR-TRI-FS------V-G---YR-LA----PE-----------------------------------FRF---PMALDD--CLTV----------------------------------------------A-----------------------------R--SVLET-----------------------------------------Y------------PVQ--------------------------------------------------------S----I-CF--I-G--AS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-MAF---------------------------------------------------------------------------------------------S--TAL----TLVSDGLGDRVQGV-------VAL------APVTV---H-----PDSVSAD-----------------NR-------DRGEYTSYEENDRL--TINTGSAMRSFF---------------------DC-YGAPPD-------------------------------------------------------------------------------------DPRLSCLLHP----GL---------------------------------------------------------------------------------------------------------GK----LN---------------------------K-------------------------VY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MA-V-----GDAD---TLRD--DVR-----------LMR-DA-L-----VAL-----------------EVPV--------------------KCDEY--PG-------------Y------------------------------------PHF--SWLFPSPALREHQALFFGNL-------------------------------------------- 559
560 -------------------PTDKSVTTEDITLKNGVWVRIYTPPAADFNATMADSDSGK------------EEKI-TVF----M-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GWI-----M---------G--SVDH---EDSAVRQ---LCRAVG-HKI-VS------V-G---YR-LA----PK-----------------------------------HKY---PVALDD--CLQA----------------------------------------------T-----------------------------L--WTLEN-----------------------------------------FA---S-------SAP--------------------------------------------------------S----V-SL--M-G--GS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------N-LAF---------------------------------------------------------------------------------------------G--VAL----RLLDSGLGDKFKGV-------HAL------VPCVV---H-----PEAVPEP-----------------KR-------E--QFTAYEENAEA--TVNTLACMRCFL---------------------DS-YGPPPD-------------------------------------------------------------------------------------DIYFSVLLHP----RI---------------------------------------------------------------------------------------------------------GD----LK---------------------------R-------------------------VY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-E-----CGTD---TLRD--DAR-----------LMR-DA-L-----IEK-----------------GVDV--------------------RYDAY--PG-------------L------------------------------------PHY--FWSYPAKAL------------------------------------------------------- 560
561 --------------------------------IAGVPVRIITPLT---IPPSHRDY------------------V-LMN----V-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------GFI-----V------------DSGS-LTETIPMAN---LTQTK----V-VS------V-L---YP-LS----PE-----------------------------------HPF---PAAVNA--SVAV----------------------------------------------Y-----------------------------K--QLLKT-YP------------------------------------AKH----------------------------------------------------------------------------I-II--Y-G--TS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I-LTG---------------------------------------------------------------------------------------------E--IAV-------------------------DLK--------------KLGLPEPCALGIF-----------------S------GFGDFSK------PGDSQSLFALDGLSGYL---------------APPNPGKL-MLPEYE--------------------------------------------------------------------------------------GKTNPRDPV----------------------------------------------------------L--SPV-----------------------------------------------YANLSGLP---------------------------P-------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-T-----STRD---LLLS--GTT-----------ILD-RK-F-----FDA-----------------GDKT--------------------QLIVF--EA-------------L------------------------------------PH--AFWNNPRMPEAKQ---------------------------------------------------- 561
562 --------------------------------------KDIV-------YKNTNNVPLKLDIYKP-LKNIYKSSPVILY----V-------H---------------------------------------------------------G--------------------G-----------------------------------------------------------------------------------------------------SWVYGDKSIPQFITPILDIFRNNGFTIISTE------------YE-LM-----------------------------------------RSHENFQKQICDIKDTLR-------------------------------------------------------------------------------WIYKN--------------------------------------------------------------------------------------------------------SENYNIDSNQ----I-GI--I-G--MS-----------------SG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LSLMSA--YTSNN--------------EFTDDIDLANYPSNVKY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFFGPTDLNLLD--TSGLNWDLTNIFNSINDRSSIASE--------------FNPI--NYINSNIPETLIIH-----SKSDS--LVPYESSLELYNKCIEEKASAKLVPL-----------------------------------------------------------------------------------------------------------EGTSHDMSNVFTQDI-INLTKEVLRFI--------------------------------------------- 562
563 -AITAQSEDC--------------------LSLNIWT-------------------------PHAASGNQ--ELPVFVY----I-------Y---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------------A--------------M--VTGGSSNAQWQGYNFAR---KDVIYVN------F-N---YR-ES-------------LYASPNAPELEGQSQ-------------------NFGIMD--VELA----------------------------------------------L-----------------------------Q--WVYDN-----------------------------IEAFG---------------------GN------------------------------------------------------KSH----I-VL--G-G--HS-----------------SG-----------------------------G-VHVDH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LWN---H-----P---------------S---------------TFLAGAIEM-----------------------------------------------------------------------------------------S-ANAQSGPAIT--PSGVGL-KKVVQDML---------------------------------------------------DAGVA-------------------------------------------------------------------------------------------------------LSCTADDYTLDCLRA-------------------------VDTYAFQTSYFN--STSNTW--------------FS----------------------------------------------------------------------P------IV----D----------------NITR----FSSYA-DR------------------------------------------FAAGQ------YPTS---------------------------------------------------------------------------------------------------------------------------LP--LI------------------V-------------------GNSDREGAIF--GYVYGSENTNFSSWIGTFDADLAFVPADELLSAYD--PADYAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAAMSGA-----SYGD------------------------------ARFFCAT-----------------------DYLLDLR----------------AAAQP----TWIYRWFGQYDNVLPIPGL-------------------------G-PSHG---------SEVPFFHGGNECFESISGVTD------------------------------------ 563
564 -------EDC--------------------LYINVFV--------------------------P---LRGPAKMAVFVY----V-------H---------------------------------------------------------G--------------------G----S-------------------------------------------------------------------------------------------------N--RVGMGAMLRGDILA-AF---GDIIVVN------F-N---YR-LG-------------SLGFYAARKEGLT-----------------G---NYGFFD--QVTA----------------------------------------------L-----------------------------N--WVKDN-----------------------------IANFG---------------------GD------------------------------------------------------PDM----I-TI--A-G--HS-----------------AG-----------------------------A-ADVGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VISPL-------S---------------K---------------GLFRRAMIM-----------------------------------------------------------------------------------------S-GSPI---------AFWGLAAPHWKPGY--------------------------------------------NIAEYC-DRELC-----------------------------------------------------------------------------------------------------------PRNRDPQDFRDYLMKLPWETF------------------------------------------------TKHEVTPIPTDYTEVLTF-------------------------------------------------------P----VSIV----DG--------------E--FI----TERPE-TA------------------------------------------IPARRTNCESFV------------------------------------------------------------------------------------------------------------------------------------------------------F-------------------SVTRDEG-SIDVVHA--VKFVLDNMKKKTGKFDEETFREVLKWYKPIYPNVPNLRD-------------------------------------------------------------------------------------------LILHEY-GGWEKFPNHTEET--------------------------------------------------------------SVLERYTKM-----ES-D------------------------------IVFVAPMVKLADLLTSADVK-D----------------------------------------ITFFSFDYRSPSSPL-----------------QEWE--------G-VPHG---------ADL-FYIFGIPYTGVPPYNK------------------------------------- 564
565 FE--DTSEDC--------------------LYLNLYI--------------------------PEVESNRSGNTSVLVF----V-------H---------------------------------------------------------G--------------------G----S-------------------------------------------------------------------------------------------------N--RDGMGSMLEGDILA-GH---GGIIVVT------I-N---YR-LG-------------IYGFVAAKDEGLD-----------------G---TYGFLD--QIEA----------------------------------------------L-----------------------------K--WVKSN-----------------------------IDQFG---------------------GN------------------------------------------------------SNM----I-TI--H-G--HS-----------------AG-----------------------------A-ANVGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-STSPM-------S---------------K---------------GLFQRVIVH-----------------------------------------------------------------------------------------S-GSPL---------AFWAMTDPQFPQGT--------------------------------------------NLKPSCSDFEDC------------------------------------------------------------------------------------------------------------RNKTYKEYLKSLNKTQLATI------------------------------------------------KGLE-TP-----RELVTF-------------------------------------------------------P-----AVV----DG--------------E--FL----PGRPN-DV------------------------------------------I-RQSLNADHFL------------------------------------------------------------------------------------------------------------------------------------------------------L-------------------AFTKDEGFPIDLKNEAYVKMVV--------SFSKANLLEVMKLYNTVFRNVKNFTE-------------------------------------------------------------------------------------------IVIKEY-KEFE------SSA--------------------------------------------------------------YILQH--KV-----DA-D------------------------------FVFFAPMIRLADLL-SQYIK-E----------------------------------------LYVFSFDHVSAHSPH-----------------PRWQ--------S-VPHG---------IDL-YYVFGAPLVGHKRFTYDD----------------------------------- 565
566 ------NEDC--------------------LFLNIWA-----P-HPRP-----------K-KT-----------PVIVF----I-------H---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------FVS-GS------GS------A--EGLRGHILAT-----VE----YVIVVT------I-N---YR-LG-------------VLGFATL-------DIDE----A-----P-G---NIGLYD--QTMA----------------------------------------------L-----------------------------K--WINQN-----------------------------IAGFG---------------------GD------------------------------------------------------PDL----V-TI--A-G--HS-----------------AG-----------------------------A-SSVSY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPM-------S---------------E---------------HLFKFAILQ-----------------------------------------------------------------------------------------S-GTAL---------SPWALSP---KDD---L---------------------------LSQTI---------GLA----KRTSC----------------------------------------------------------PSAKPGNRTS---------------------------------------ALE-TITCLRG--D------I------------------------------------------------NLTPLIRH---WE-KN--AHSS---------------------------------------------------P------MV----DG--------------L--FL----PDTPH-NL------------------------------------------LSSGR------F-KN---------------------------------------------------------------------------------------------------------------------------TS--IL------------------L-------------------GFNQDESVLN-------LM-------RFD-------EFSHDPITIAE--HTPSLS---------HDTF----------------------RDRI-QSLF-------SDF----------------------DDRQV-E---------TIAFQY----RNWYRP---------------------------------------Y---DP-YEFR----------------N---SLANM-----WS-D------------------------------YSICCP----TLDFVAYF-TAS-----K-------------------------------QD-AYVYYF-------NH-RNSLNAW------PT---WV--------G-VPHG---------DEL-AFVLG------LALE--DEI--------------------------------- 566
567 TGDVPLDEDC--------------------LYLGVVV--------PDS-----------I-PKA---A------SVLVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FTW-GT------AE------R--HLGDHNNKLT-----SH---ESVIFVA------M-N---YR-LG-------------VFGFLAM-------NSPDA---------P-G---NMGLLD--QQLA----------------------------------------------L-----------------------------K--WVHEN-----------------------------IAAFG---------------------GD------------------------------------------------------PDK----I-TI--A-G--VS-----------------AG-----------------------------G-TSVAY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LFSPG-------S---------------R---------------GLYRRAILQ-----------------------------------------------------------------------------------------S-SYVLN--------HKRSFVSGGD------A---------------------------KDRSM---------QFS----KKVNC----------------------------------------------------------DGDS---------------------------------------------GDVKLLQCLR---G------M------------------------------------------------PAEQLMNN-------------------------QDAFTVYRTPFP----------------------------P------VI----DG--------------Q--FI----TDEPR-AL------------------------------------------VKKAE------F-EK---------------------------------------------------------------------------------------------------------------------------IP--IL------------------L-------------------GTLQHETGD------------------MT------FRAGIPGLSANN-----------------GFQF----------------------KYNKLHDVLTHCFPTAADV----------------------------S---------PIIEQY---------------------------------------------VKRNN---SEPTYFR----------------D---LLMDI-----TA-D------------------------------YSYVCP----SLEFATLY-SNV-----G--------------------------------LPVYYYEF-------DH-RPSVSI--------A-PEWM--------G-AVHG---------DEV-PFLFG------FPLK--EGQDIRHHTIEE------------------------ 567
568 ----QIREDC--------------------LYINVWT-------------------------PS---ASSTSKLPVFVF----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------YFY-GS------GS----------RWQGKVLAS-----NQ----NIIVVT------M-N---YR-LG-------------AFGFMTP--------GEKV---DGKHVIE-P---NLGLYD--QRLA----------------------------------------------L-----------------------------Q--WVREN-----------------------------IAQFG---------------------GD------------------------------------------------------PNK----I-TA--S-G--NS-----------------VG-----------------------------A-MSVGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-TMSPG-------S---------------K---------------GLIHRAILD-----------------------------------------------------------------------------------------S-GTP--------QFPEFFHPDFTTP---------------------------------RKVFE---------EAV----KHSNC----------------------------------------------------------ARA----------------------------------------------NTAETVACLQD--L-------------------------------------------------------PMQELLGAQFKTM-GVYPFGFS---------------------------------------------------V------AV----DD--------------Q--FL----PDNPE-TL------------------------------------------LKNGQ------Y-EK---------------------------------------------------------------------------------------------------------------------------VP--TM------------------I-------------------GTTSDDGSV------------------FV------RMGGYPDIEKGLS------------------------------------------TENFFASIDVFFKAFSKQTRS------------------------------------AIKFRY----TNWIKE-------------------------------------------NDPLAVR----------------D---EATKL-----FN-D------------------------------YFFAAP----ADKCAQQY-ASD-------------------------------------GVPTYYFEF-------AFPTKLSFIF---------PSYL--------G-VTHT---------MEM-PQVVG------YPIDKPASFLA------------------------------- 568
569 -----VNEDC--------------------LYMNVWT-------------------------PT---TNNASNLAVFVF----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------YYY-GS------GS----------RWQGKVLSA-----NQ----NIVTVT------M-N---YR-LG-------------AFGFMT---------TSKV---NDNYPIE-P---NLGLLD--QQLA----------------------------------------------L-----------------------------K--WIRNN-----------------------------IAKFG---------------------GN------------------------------------------------------PQN----V-TI--A-G--NS-----------------VG-----------------------------A-VSVGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-TMSQG-------S---------------K---------------GLFHRIIME-----------------------------------------------------------------------------------------S-GAP--------IMPQFYYVDFKIP---------------------------------NIVFQ---------KVA----QLSNC----------------------------------------------------------SRS----------------------------------------------TAAQIVTCLRA--L-------------------------------------------------------TMKELLTAQLTTM-ATYPLGFV---------------------------------------------------V------VA----GG--------------Q--FL----PDSPE-TL------------------------------------------LKNGQ------Y-EK---------------------------------------------------------------------------------------------------------------------------VN--TM------------------L-------------------GTTTDDGSI------------------FL------QVNRYQNIGQGLP------------------------------------------RAVFLGTIAGYFAAYSQQSRS------------------------------------AIEYQY----TKYAKE-------------------------------------------NDPIANR----------------D---EINKL-----FN-D------------------------------FFFVAP----ADKCARKY-SAD-------------------------------------GVSTYYYEF-------AFRTQLSTAF---------PPYM--------G-VTHT---------MEV-PYVMG------YPINRPSSFS-------------------------------- 569
570 ------NEDC--------------------LYLNIFT-------------------------SN---PSNVANMSVLVY----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------YVL-GS------GS----------QWQGQILAA-----HE----NIVVVT------I-N---YR-VG-------------VLGFMTS--------GEED---SARRAIQ-A---NLGLLD--QSLA----------------------------------------------L-----------------------------Q--WVKDN-----------------------------IENFG---------------------GN------------------------------------------------------PDF----I-TI--A-G--NS-----------------AG-----------------------------G-LSAMY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LVMPS-------S---------------K---------------GLFRGAILQ-----------------------------------------------------------------------------------------S-G-PY------GTIPSYIKSGTSMPDTLARA---------------------------KISFQ---------QFS----SLANC----------------------------------------------------------TKN----------------------------------------------TTSKIVECLKT--L-------------------------------------------------------SVQQLLNIQSTLR-PRNRILTS---------------------------------------------------P------VA----DG--------------N--NV----QEALH-TA------------------------------------------IPAGR------F-HK---------------------------------------------------------------------------------------------------------------------------VN--IM------------------L-------------------GTTLNDG--------------------YF------RLPSMPNAVTGIP------------------------------------------RQNFISTTNNSFPFASQRVKL------------------------------------SIQYRY----TNWSNA-------------------------------------------NSPISNR----------------D---QYGEL-----FN-D------------------------------FVFAIPNIYYADQLSR-------------------------------------------FVPTYKYIF-------AHRTS-GTWQ---------PSYV--------K-VAHT---------MEI-PYMLG------YPLDKPSE---------------------------------- 570
571 APESIINENC--------------------LYLNVFT--------TAP-----------S-IAG----N---K-SVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------YIG-GS------GA------N----WQPQTLAV-----TE----DIVVVT------M-N---YR-LG-------------IFGFTTS--------GEAN---ANSRSIQ-A---NLGFLD--QQLA----------------------------------------------M-----------------------------A--WVQNN-----------------------------IEQFG---------------------GK------------------------------------------------------KDA----V-TL--A-G--FS-----------------AG-----------------------------S-FAVGI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LVAPS-------S---------------S---------------GLYRYAIME-----------------------------------------------------------------------------------------S-GTIL---------D----GR--SVAE---A---------------------------RATFL---------RIG----QVGQC-----------------------------------------------------------NTS---------------------------------------------NLRAIYQCIN---K------YN------------------------------------------------STILL-Q----I-QFALLREN-------------------PANFG---------------------------L------VI----DG--------------R--FL----NENPR-KL------------------------------------------LQDGR------F-FK---------------------------------------------------------------------------------------------------------------------------GR--LL------------------I-------------------GTTLQDG-----------------------------YSFIP----------PLVT---------RQVF----------------------LGYV-SNWFREYPPSA--R----------------------ASVI---------------NRY----TDYTNI--------------------------------------DS---PT-VNRM----------------K---L--GE-----LSND------------------------------ALFLST----SDFMAQKY-SKH--------------------------------------APTYNYVW-------TY-HTQQDIYL--------PAYM--------G-VTHS---------MDV-PYFYG------------------------------------------------ 571
572 -------EDC--------------------LFLNIHI------------------------PG--GTINRTKRLPILVY----I-------H---------------------------------------------------------G--------------------G----N-----------------------------------------------------------------------------YFF-GC------S----------NIYRGSAF----AT-KQ----NVIIIT------I-N---YR-LN-------------YFGFLSTGDDR----IPG----------------NMGLLD--QVQA----------------------------------------------L-----------------------------Q--WIHDN-----------------------------IEAFG---------------------GD------------------------------------------------------PDK----V-TL--L-G--ES-----------------AG-----------------------------A-WCVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-AISPRSK-----N--------------------------------LFKRAIVM-----------------------------------------------------------------------------------------S-GVEY---------------TRNLTTN--RF---------------------------LEKENSIQAL----------LDTVHC----------------------------------------------------------SNASD--------------------------------------------V----VKCLQG--V-------------------------------------------------------DARQLLMSKYWQQ-------A----------------------------------------------------P------VV----DG--------------EGGFL----PMQPKELW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESGNLN-------------MDSLLG-------------------GTVRHDGEVV--------------------------------------------------------------------------------------------VR--------KYVDDLLIWFDTSLDQRGFSENDV-----KLKN--IIVDQY-IGDSSVQ--L-----------------------------------------------------------------SNLLATIEL-----FT-D------------------------------SVFVAE----TRNALDRIRDL--------------------------------------GRQGYLYYHTHKGLLSPSGYP------IEV-----------------G-PFHA---------EGI-HYLFGIYADEELAMYNA------------------------------------ 572
573 TMPTEFGEDC--------------------LFLNIHI------------------------PG--GTINRTKRLPILVY----I-------H---------------------------------------------------------G--------------------G----N-----------------------------------------------------------------------------YFF-GC------S----------NIYRGSAF----AT-KQ----NVIIIT------I-N---YR-LN-------------YFGFLSTGDDR----IPG----------------NMGLLD--QVQA----------------------------------------------L-----------------------------Q--WIHDN-----------------------------IEEFG---------------------GD------------------------------------------------------PDK----V-TL--L-G--ES-----------------AG-----------------------------A-WCVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-AISPRSK-----N--------------------------------LFKRAIVM-----------------------------------------------------------------------------------------S-GLEY---------------TRNLTTN--RF---------------------------LEKENSIQAL----------LDTVHC----------------------------------------------------------SNASD--------------------------------------------V----VKCLQG--V-------------------------------------------------------DARQLLMSKYWQQ-------A----------------------------------------------------P------VV----DG--------------EGGFL----PMQPKELW------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ESGNLN-------------MDSLLG-------------------GTVRHDGEVVVRLLKEVV------------------------------------------------------------------------HLDFVNGISIEQVR--------KYVDDLLIWFDTSLDQRGFSENDV-----KLKN--IIVDQY-IGDPSDQ--L-----------------------------------------------------------------SNLLATIEL-----FT-D------------------------------SVFVAE----TRNALDRIRDL--------------------------------------GRQGYLYYHTHKGLLSPSGYP------IEV-----------------G-PFHA---------EGI-HYLFGIYADEELAMYNA------------------------------------ 573
574 NANTKLSEDC--------------------LYLNVYV-----PGKVDP-------------------NKK--L-AVMVW----V-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FWS-GT------AT------L--DVYDGRILTV-----EE----NVILVA------M-N---YR-VS-------------IFGFLYM--------NRPE---A-----P-G---NMGMWD--QLLA----------------------------------------------M-----------------------------K--WVHKN-----------------------------IDLFG---------------------GD------------------------------------------------------LSR----I-TL--F-G--ES-----------------AG-----------------------------A-ASVSI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-MLSPK-------S---------------A---------------PYFHRAIIQ-----------------------------------------------------------------------------------------S-GSAT---------SPWAIEP---RDV---A---------------------------LARAV---------ILY----NAMKC----------------------------------------------------------GNMSLINPD-----------------------------------------YDRILDCFQ---R------A------------------------------------------------DADALREN----E-WAPVRE-----------------F-GDFPWV----------------------------P------VV----DG--------------D--FL----LENAQ-TS------------------------------------------LKQGN------F-KK---------------------------------------------------------------------------------------------------------------------------TQ--LL------------------A-------------------GSNRDESIY------------------FL-------TYQLPDIFPVA--DFFTKTDF----IKDRQLW----------------------IKGVKDLL--------P----------------------------R-QILKCQLTLAAVLHEY--------EP--------------------------------------QD---LP-VTPR----------------DWINAMDKM-----LG-D------------------------------YHFTCS----VNEMALAH-TKH-----GG------------------------------D--TYYYYF-------TH-RASQQTW-------P--EWM--------G-VLHG---------YEI-NFIFG------EPLN--QKRFNYTD---------------------------- 574
575 NPNTKLSEDC--------------------LYLNVYV-----PGKVDP-------------------NKK--L-AVMIW----V-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FWS-GT------ST------L--DVYDGRILTV-----EE----NVILVA------M-N---YR-VS-------------IFGFLYM--------NRSE---A-----P-G---NMGMWD--QLLA----------------------------------------------M-----------------------------K--WVHKN-----------------------------IDLFG---------------------GD------------------------------------------------------TSR----I-TL--F-G--ES-----------------AG-----------------------------A-ASVSI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-MLSQK-------S---------------A---------------PYFHRAIIQ-----------------------------------------------------------------------------------------S-GSAT---------SPWAIEP---RDV---A---------------------------LARAV---------ILY----NAMKC----------------------------------------------------------GNMSLISPD-----------------------------------------YDRILDCFQ---R------A------------------------------------------------DADALREN----E-WAPVRE-----------------F-GDFPWV----------------------------P------VV----DG--------------D--FL----LENAQ-TS------------------------------------------LKQGN------F-KK---------------------------------------------------------------------------------------------------------------------------TQ--LL------------------A-------------------GSNRDESIY------------------FL-------TYQLPDIFPVA--DFFSKSEF----IKDRQTW----------------------IKGVKDLL--------P----------------------------R-QILKCQLTLAAVLHEY--------EP--------------------------------------QD---LP-ISAQ----------------NWLNAMDKM-----LG-D------------------------------YHFTCS----VNEMALAH-TKH-----GG------------------------------D--TFYYYF-------TH-RATQQTW-------P--EWM--------G-VLHG---------YEI-NFIFG------EPFN--QKRFNYTD---------------------------- 575
576 VPNTPMSEDC--------------------LFLNIWV----------P-----------IKESNGSHPNSKEKLAVMLW----I-------Y---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------FYM-GT------ST------L--SVYDARFLAA-----RQ----NIIVAS------M-N---YR-LG-------------SFGFLYM--------NTEEAP---------G---NMGLWD--QRLA----------------------------------------------M-----------------------------K--WIKDH-----------------------------IEHFG---------------------GD------------------------------------------------------PYR----I-TL--F-G--ES-----------------AG-----------------------------A-VSVST---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VVSPW-------S---------------H---------------SYYNNAIMQ-----------------------------------------------------------------------------------------S-GSIF---------SNWGLAT------SEVS---------------------------LNQTQ---------RLA----KILGC----------------------------------------------------------GYR----------------------------------------------SSNDQIKCLRS--K-------------------------------------------------------SITEILDAHDTMY-DPA-SYFSVPFPP----------------------------------------------V-------L----DN--------------N--FF----PYENSQ-S------------------------------------------FRQLK------Y-LK---------------------------------------------------------------------------------------------------------------------------PSGALM------------------F-------------------GINKNEGSYF-------LL-------YAFVSNSKW---------MKNLTDLPITN---------RMDY----------------------LRCLRQVLDLDDDDERPEFTEP-----------------------------------LIRY------------------------------------------------------------TDFEYQTYQQLPTLESWTE---RLEEI-----SS-D------------------------------RSFKCP----TINMATAVTNDY------------------------RI----PGRRRAHTLPVYFYEF-------QH-RTVSLPM---------PKWT--------G-TMHG---------YEI-EYVFG------IPFSPQFQASFYRFTDEE------------------------ 576
577 NPNTPISEDC--------------------LYLNVWQ-----P-TPAP--------------------TG--A-TVLVW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FFS-GT------SS------L--DVYDGRYLAR-----ME----DVVVVS------M-N---YR-LG-------------ALGFL-Y-------SGSEA---A-----P-G---NVGLLD--QHLA----------------------------------------------L-----------------------------L--WVQQN-----------------------------VHAFG---------------------GD------------------------------------------------------PAK----V-TI--F-G--ES-----------------AG-----------------------------A-ASVNF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-MISPM-------S---------------R---------------NLFQRAIMQ-----------------------------------------------------------------------------------------S-ASAL---------APWALRP---SEQ---A---------------------------RKRTK---------ALA----IDIGC----------------------------------------------------------SA--EEEDMD---------------------------------------ALVA---CLR---D------V------------------------------------------------PAQTILDH----E-WNVVDLTG------------AHFL-ADIPFP----------------------------P------IK----DG--------------S--FL----TEDPT-EV------------------------------------------YEKGT------F-KD---------------------------------------------------------------------------------------------------------------------------ID--IL------------------V-------------------GFVKNEGNF------------------WL-------VYGVPG-FSKD--TDSIID---------RDTF----------------------VGDI-EFCH-------PWL----------------------NDITV-E---------ATAFEY----TDWLHM---------------------------------------D---QD-TMYR----------------D---ALDSV-----FG-D------------------------------YFFVCP----TTAVGKGH-VNH-----GR------------------------------T--AYVYEF-------AQ-VASNLAW-------P--HWM--------G-AMHG---------YEI-EFIFG------LPID--PK-WNYTAE--------------------------- 577
578 NPNTPVSEDC--------------------LYLNVWQ-----P-SPVP--------------------VG--A-TVMVW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FMS-GT------SS------L--DVYDGRYLAR-----TQ----GVIVAS------M-N---YR-TG-------------AMGFLSL--------GNSE---A-----P-G---NVGLMD--QNLA----------------------------------------------L-----------------------------T--WIKEN-----------------------------VASFG---------------------GA------------------------------------------------------PNK----V-SI--F-G--ES-----------------AG-----------------------------A-ASVSY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPM-------S---------------K---------------NLFQRAIME-----------------------------------------------------------------------------------------S-ASAP---------SPWALLS---DTE---A---------------------------YRRGI---------ELP----KAVGC----------------------------------------------------------ST---DSDLE---------------------------------------ETIE---CMR---G------V------------------------------------------------PAQTISDN----E-WVVWG------------------L-CQFPFA----------------------------P------IV----DG--------------N--FI----REHPT-QS------------------------------------------LQTGN------L-KQ---------------------------------------------------------------------------------------------------------------------------TD--VL------------------V-------------------GFNNDEGVY------------------FL-------LYGAPG-FSKD--TRSLIT---------REQY----------------------LEGI-KMSV-------MGI----------------------NDISV-D---------ALSFQY----IDWVNF---------------------------------------D---QP-SMYR----------------D---AIDDL-----SG-D------------------------------YNFICP----ALSFGKAM-ASL-----GR------------------------------K--TYQYKF-------VH-QASNMPW-------P--KWT--------G-VMHG---------YEC-EFVFG------LPTD--QK-NNYTQE--------------------------- 578
579 NPNRELSEDC--------------------LYLNVWTPYPRPA-SPTP---------------------------VLIW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FYS-GA------SS------L--DVYDGRFLTQ-----AE----GTVLVS------M-N---YR-VG-------------AFGFLAL-------PGSRE---A-----P-G---NVGLLD--QRLA----------------------------------------------L-----------------------------Q--WVQEN-----------------------------VAAFG---------------------GD------------------------------------------------------PTS----V-TL--F-G--ES-----------------AG-----------------------------A-ASVGM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPP-------S---------------R---------------GLFHRAVLQ-----------------------------------------------------------------------------------------S-GAPN---------GPWATVG---VGE---A---------------------------RRRAT---------LLA----RLVGC----------------------------------------------------------PLGGTGGNDT---------------------------------------ELVA---CLR---T------R------------------------------------------------PAQDLVDH----E-WHVLPQES---------------V-FRFSFV----------------------------P------VV----DG--------------D--FL----SDTPE-AL------------------------------------------INAGD------F-HS---------------------------------------------------------------------------------------------------------------------------LQ--VL------------------V-------------------GVVKDEGSY------------------FL-------VYGAPG-FSKD--NESLIS---------RAQF----------------------LAGV-RVGV-------PQA----------------------SDLAA-E---------AVVLHY----TDWLHP---------------------------------------E---DP-ARLR----------------E---AMSDV-----VG-D------------------------------HNVVCP----VAQLAGRL-AAQ-----GA------------------------------R--VYAYIF-------EH-RASTLSW-------P--LWM--------G-VPHG---------YEI-EFIFG------LPLE--PS-LNYTIE--------------------------- 579
580 NPNRELSEDC--------------------LYLNVWTPYPRPA-SPTP---------------------------VLVW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FYS-GA------SS------L--DVYDGRFLAQ-----AE----GTVLVS------M-N---YR-VG-------------AFGFLAL-------PGSRE---A-----P-G---NVGLLD--QRLA----------------------------------------------L-----------------------------Q--WVQDN-----------------------------VATFG---------------------GD------------------------------------------------------PMS----V-TL--F-G--ES-----------------AG-----------------------------A-ASVGM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPP-------S---------------R---------------GLFHRAVLQ-----------------------------------------------------------------------------------------S-GAPN---------GPWATVG---VGE---A---------------------------RRRAT---------LLA----RLVGC----------------------------------------------------------PPGGAGGNDT---------------------------------------ELVA---CLR---T------R------------------------------------------------PAQDLVDH----E-WHVLPQES---------------V-FRFSFV----------------------------P------VV----DG--------------D--FL----SDTPE-AL------------------------------------------INAGD------F-HG---------------------------------------------------------------------------------------------------------------------------LQ--VL------------------V-------------------GVVKDEGSY------------------FL-------VYGAPG-FSKD--NESLIS---------RAQF----------------------LAGV-RVGV-------PQA----------------------SDLAA-E---------AVVLHY----TDWLNP---------------------------------------E---DP-ARLR----------------E---AMSDV-----VG-D------------------------------HNVVCP----VAQLAGRL-AAQ-----GA------------------------------R--VYAYIF-------EH-RASTLSW-------P--LWM--------G-VPHG---------YEI-EFIFG------LPLE--PS-LNYTAE--------------------------- 580
581 NPNRELSEDC--------------------LYLNVWTPYPRPS-SPTP---------------------------VLVW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FYS-GA------SS------L--DVYDGRFLTQ-----AE----GTVLVS------M-N---YR-VG-------------AFGFLAL-------PGSRE---A-----P-G---NVGLLD--QRLA----------------------------------------------L-----------------------------Q--WVQEN-----------------------------VAAFG---------------------GD------------------------------------------------------PTS----V-TL--F-G--ES-----------------AG-----------------------------A-ASVGM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPP-------S---------------R---------------GLFHRAVLQ-----------------------------------------------------------------------------------------S-GAPN---------GPWATVG---VGE---A---------------------------RRRAT---------LLA----RLVGC----------------------------------------------------------PPGGAGGNDT---------------------------------------ELVA---CLR---A------R------------------------------------------------PAQDLVDH----E-WRVLPQES---------------V-FRFSFV----------------------------P------VV----DG--------------D--FL----SDTPE-AL------------------------------------------INAGD------F-HG---------------------------------------------------------------------------------------------------------------------------LQ--VL------------------V-------------------GVVKDEGSY------------------FL-------VYGAPG-FSKD--NESLIS---------RAQF----------------------LAGV-RVGV-------PQA----------------------SDLAA-E---------AVVLHY----TDWLHP---------------------------------------E---DP-ARLR----------------E---ALSDV-----VG-D------------------------------HNVVCP----VAQLAGRL-AAQ-----GA------------------------------R--VYAYIF-------EH-RASTLSW-------P--LWM--------G-VPHG---------YEI-EFIFG------LPLE--PS-LNYTIE--------------------------- 581
582 NPNRELSEDC--------------------LYLNVWTPYPRPA-SPTP---------------------------VLVW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FYS-GA------SS------L--DVYDGRFLAQ-----AE----GTVLVS------M-N---YR-VG-------------AFGFLAL-------PGSRE---A-----P-G---NVGLLD--QRLA----------------------------------------------L-----------------------------Q--WVQEN-----------------------------VATFG---------------------GD------------------------------------------------------PRA----V-TV--F-G--ES-----------------AG-----------------------------A-ASVGM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPP-------S---------------R---------------GLFHRAVLQ-----------------------------------------------------------------------------------------S-GAPN---------GPWATVG---VGE---A---------------------------RRRAT---------LLA----RLVGC----------------------------------------------------------PPGGAGGNDT---------------------------------------ELVA---CLR---T------R------------------------------------------------PAQDLVDH----E-WHVLPQES---------------V-FRFSFV----------------------------P------VV----DG--------------D--FL----SDTPE-AL------------------------------------------ISAGD------F-HG---------------------------------------------------------------------------------------------------------------------------LQ--VL------------------V-------------------GVVKDEGSY------------------FL-------VYGAPG-FSKD--NESLIS---------RAQF----------------------LAGV-RVGV-------PQA----------------------SDLAA-E---------AVVLHY----TDWLHP---------------------------------------E---DP-ARLR----------------E---AMSDV-----VG-D------------------------------HNVVCP----VAQLAGRL-AAQ-----GA------------------------------R--VYAYIF-------EH-RSSTLTW-------P--LWM--------G-VPHG---------YEI-EFIFG------LPLE--PS-LNYTAE--------------------------- 582
583 NPNRELSEDC--------------------LYLNVWTPYPRPA-SPTP---------------------------VLIW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FYS-GA------AS------L--DVYDGRFLAQ-----VE----GAVLVS------M-N---YR-VG-------------TFGFLAL-------PGSRE---A-----P-G---NVGLLD--QRLA----------------------------------------------L-----------------------------Q--WVQEN-----------------------------IAAFG---------------------GD------------------------------------------------------PMS----V-TL--F-G--ES-----------------AG-----------------------------A-ASVGM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-ILSLP-------S---------------R---------------SLFHRAVLQ-----------------------------------------------------------------------------------------S-GTPN---------GPWATVS---AGE---A---------------------------RRRAT---------LLA----RLVGC----------------------------------------------------------PPGGAGGNDT---------------------------------------ELIA---CLR---T------R------------------------------------------------PAQDLVDH----E-WHVLPQES---------------I-FRFSFV----------------------------P------VV----DG--------------D--FL----SDTPE-AL------------------------------------------INTGD------F-QD---------------------------------------------------------------------------------------------------------------------------LQ--VL------------------V-------------------GVVKDEGSY------------------FL-------VYGVPG-FSKD--NESLIS---------RAQF----------------------LAGV-RIGV-------PQA----------------------SDLAA-E---------AVVLHY----TDWLHP---------------------------------------E---DP-THLR----------------D---AMSAV-----VG-D------------------------------HNVVCP----VAQLAGRL-AAQ-----GA------------------------------R--VYAYIF-------EH-RASTLTW-------P--LWM--------G-VPHG---------YEI-EFIFG------LPLD--PS-LNYTTE--------------------------- 583
584 NPNRELSEDC--------------------LYLNVWTPYPRPT-SPTP---------------------------VLVW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FYS-GA------SS------L--DVYDGRFLVQ-----AE----RTVLVS------M-N---YR-VG-------------AFGFLAL-------PGSRE---A-----P-G---NVGLLD--QRLA----------------------------------------------L-----------------------------Q--WVQEN-----------------------------VAAFG---------------------GD------------------------------------------------------PTS----V-TL--F-G--ES-----------------AG-----------------------------A-ASVGM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPP-------S---------------R---------------GLFHRAVLQ-----------------------------------------------------------------------------------------S-GAPN---------GPWATVG---MGE---A---------------------------RRRAT---------QLA----HLVGC----------------------------------------------------------PPGGTGGNDT---------------------------------------ELVA---CLR---T------R------------------------------------------------PAQVLVNH----E-WHVLPQES---------------V-FRFSFV----------------------------P------VV----DG--------------D--FL----SDTPE-AL------------------------------------------INAGD------F-HG---------------------------------------------------------------------------------------------------------------------------LQ--VL------------------V-------------------GVVKDEGSY------------------FL-------VYGAPG-FSKD--NESLIS---------RAEF----------------------LAGV-RVGV-------PQV----------------------SDLAA-E---------AVVLHY----TDWLHP---------------------------------------E---DP-ARLR----------------E---ALSDV-----VG-D------------------------------HNVVCP----VAQLAGRL-AAQ-----GA------------------------------R--VYAYVF-------EH-RASTLSW-------P--LWM--------G-VPHG---------YEI-EFIFG------IPLD--PS-RNYTAE--------------------------- 584
585 NPNRVMSEDC--------------------LYLNVWV----PP-TPRP--------------------QN--L-TVMVW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FYS-GS------SS------L--DVYDGRYLAY-----TE----KVVVVS------M-N---YR-VG-------------AFGFLAL-------NGSSD---A-----P-G---NVGLYD--QRLA----------------------------------------------L-----------------------------Q--WVQEN-----------------------------IHFFG---------------------GN------------------------------------------------------PKQ----V-TI--F-G--ES-----------------AG-----------------------------A-ASVGM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VLSPD-------S---------------R---------------PLFTRAILQ-----------------------------------------------------------------------------------------S-GVPN---------TPWATVT---FDE---A---------------------------RRRTT---------KLG----KLVGC----------------------------------------------------------TW----GNDT---------------------------------------ELID---CLR---N------K------------------------------------------------HPQELIDQ----E-WQVLPWSS---------------L-FRFSFV----------------------------P------VV----DG--------------V--FF----PDTPD-AM------------------------------------------ISSGN------F-KY---------------------------------------------------------------------------------------------------------------------------TQ--IL------------------L-------------------GVNQDEGSY------------------FL-------LYGAPG-FSKD--NESLIS---------REDF----------------------LESV-KMGV-------PHA----------------------NDIGL-E---------AVILQY----TDWMDE---------------------------------------N---NG-QKNR----------------D---AMDDI-----VG-D------------------------------QNVICP----LQHFAKSY-AQY-----AALHAQSSAAAPGTLGWGNSGPTGYNSGNSHGA--VYLYLF-------DH-RASNLAW-------P--EWM--------G-VIHG---------YEI-EFVFG------LPLE--KR-LNYTAE--------------------------- 585
586 NPNREMSEDC--------------------LYLNVWTQKGDPT-EP-P---------------------------VLVW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FTG-GS------VS------L--DVYDGRYLAA-----AE----EAVVVS------M-N---YR-VG-------------SLGFLAL-------AGHRD---A-----P-G---NVGLWD--QRLA----------------------------------------------L-----------------------------Q--WVRDN-----------------------------AEAFG---------------------GD------------------------------------------------------PDL----I-TL--F-G--ES-----------------AG-----------------------------A-ASVGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPH-------S---------------K---------------GLFRRAVLQ-----------------------------------------------------------------------------------------S-GSPN---------GPWATIG---AAE---G---------------------------RRRAA---------ALG----RAVGC----------------------------------------------------------PY----GNET---------------------------------------EFLG---CLR---G------K------------------------------------------------EAADVLEG----E-GVVMPPQS---------------V-FRFAFV----------------------------P------VV----DG--------------D--FV----VDSPDVALWGDYGVKGGEGGHGVEGGDGGYGVKGGDGVKGGYGGGYGARGVREGD------G-DGGYGVKEGLREGYGVKEGYGVEGDGANAYGARVPPRPHRDETPPDAYGAKGSADAYGAKAAPRPHRDETSPDAYGAKMPPRPHRDEASPDTYGAKMPPRPHRDETSPDAYGAKMPPRPHRAGGEVE--VL------------------L-------------------GAVRVEGSY------------------FL-------VYGVPG-FGKD--NESLIS---------REEF----------------------LGGV-RMGV-------PQA----------------------TELAA-E---------AVVLHY----TDWLDA---------------------------------------D---NP-VKNR----------------E---ALDDI-----VG-D------------------------------HNVVCP----LMAFAQRW-AQR-----GG------------------------------K--VYAYLF-------DH-RSSTLLW-------P--SWM--------G-VPHG---------YEI-EFVFG------LPLE--PR-NNYTR---------------------------- 586
587 NPNTDLSEDC--------------------LYLNVWI-----P-TPKP--------------------KN--A-TVMIW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FQT-GT------SS------L--PVYDGKFLAR-----VE----RVIVVS------M-N---YR-VG-------------ALGFLAL-------PGNPE---A-----P-G---NLGLFD--QQLA----------------------------------------------L-----------------------------Q--WVQKN-----------------------------IAAFG---------------------GN------------------------------------------------------PKS----V-TL--F-G--ES-----------------AG-----------------------------A-GSVGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPR-------S---------------Q---------------PLFTRAILQ-----------------------------------------------------------------------------------------S-GSSN---------APWAVMS---LEE---A---------------------------RNRTL---------TLA----KFIGC----------------------------------------------------------SR----ENET---------------------------------------EIIK---CLR---N------K------------------------------------------------DPQEILLN----E-VLVVPSDT---------------L-LSVNFG----------------------------P------IV----DG--------------D--FL----TDMPD-TL------------------------------------------LQLGQ------F-KK---------------------------------------------------------------------------------------------------------------------------AQ--IL------------------V-------------------GVNKDEGTA------------------FL-------VYRAPG-FSKD--NDSIIT---------RKEF----------------------QEGL-KMYF-------PGV----------------------SEFGR-E---------SILFYY----VDLLDD---------------------------------------Q---RD-EKYR----------------D---ALDDV-----LG-D------------------------------YNIICP----ALEFTKKF-SEL-----GN------------------------------N--AFFYYF-------EH-RSSQLPW-------P--KWM--------G-VMHG---------YEI-EFVFG------LPLE--RR-ANYTKA--------------------------- 587
588 NPNTDLSEDC--------------------LYLNVWI-----P-TPKP--------------------KN--A-TVMIW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FQT-GT------SS------L--PVYDGKFLAR-----VE----RVIVVS------M-N---YR-VG-------------ALGFLAL-------PGNPE---V-----P-G---NMGLFD--QQLA----------------------------------------------L-----------------------------Q--WVQKN-----------------------------IAAFG---------------------GN------------------------------------------------------PKS----V-TL--F-G--ES-----------------AG-----------------------------A-GSVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPR-------S---------------Q---------------PLFTRAILQ-----------------------------------------------------------------------------------------S-GSSN---------APWAVMS---LDE---A---------------------------KNRTL---------TLA----KFIGC----------------------------------------------------------SK----ENDT---------------------------------------EIIK---CLR---N------K------------------------------------------------DPQEILLN----E-LLVVPSDT---------------L-LSVNFG----------------------------P------VV----DG--------------D--FL----TDMPD-TL------------------------------------------LQLGQ------F-KK---------------------------------------------------------------------------------------------------------------------------TQ--IL------------------V-------------------GVNKDEGTA------------------FL-------VYGAPG-FSKD--NDSIIT---------RKEF----------------------QEGL-KIYF-------PGV----------------------SEFGR-E---------AILFYY----VDLLDD---------------------------------------Q---RA-EKYR----------------E---ALDDV-----LG-D------------------------------YNIICP----ALEFTTKF-SEL-----GN------------------------------N--AFFYYF-------EH-RSSQLPW-------P--EWM--------G-VMHG---------YEI-EFVFG------LPLE--RR-VNYTRA--------------------------- 588
589 NPNTELSEDC--------------------LYLNVWI-----P-APKP--------------------KN--A-TVMIW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FQT-GT------SS------L--PVYDGKFLAR-----VE----RVIVVS------M-N---YR-VG-------------ALGFLAL-------SENPE---A-----P-G---NMGLFD--QQLA----------------------------------------------L-----------------------------Q--WVQKN-----------------------------IAAFG---------------------GN------------------------------------------------------PRS----V-TL--F-G--ES-----------------AG-----------------------------A-ASVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPR-------S---------------Q---------------PLFTRAILQ-----------------------------------------------------------------------------------------S-GSSN---------APWAVTS---LYE---A---------------------------RNRTL---------TLA----KRMGC----------------------------------------------------------SR----DNET---------------------------------------EMIK---CLR---D------K------------------------------------------------DPQEILLN----E-VFVVPYDT---------------L-LSVNFG----------------------------P------TV----DG--------------D--FL----TDMPD-TL------------------------------------------LQLGQ------F-KR---------------------------------------------------------------------------------------------------------------------------TQ--IL------------------V-------------------GVNKDEGTA------------------FL-------VYGAPG-FSKD--NNSIIT---------RKEF----------------------QEGL-KIFF-------PRV----------------------SEFGR-E---------SILFHY----MDWLDD---------------------------------------Q---RA-ENYR----------------E---ALDDV-----VG-D------------------------------YNIICP----ALEFTRKF-SEL-----GN------------------------------D--AFFYYF-------EH-RSTKLPW-------P--EWM--------G-VMHG---------YEI-EFVFG------LPLE--RR-VNYTRA--------------------------- 589
590 NPNTDLSEDC--------------------LYLNVWI-----P-APKP--------------------KN--A-TVLIW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FQT-GT------SS------L--HVYDGKFLAR-----VE----RVIVVS------M-N---YR-VG-------------ALGFLAL-------PGNPE---A-----P-G---NMGLFD--QQLA----------------------------------------------L-----------------------------Q--WVQKN-----------------------------IAAFG---------------------GN------------------------------------------------------PKS----V-TL--F-G--ES-----------------AG-----------------------------A-ASVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPG-------S---------------H---------------SLFTRAILQ-----------------------------------------------------------------------------------------S-GSFN---------APWAVTS---LYE---A---------------------------RNRTL---------NLA----KLTGC----------------------------------------------------------SR----ENET---------------------------------------EIIK---CLR---N------K------------------------------------------------DPQEILLN----E-AFVVPYGT---------------P-LSVNFG----------------------------P------TV----DG--------------D--FL----TDMPD-IL------------------------------------------LELGQ------F-KK---------------------------------------------------------------------------------------------------------------------------TQ--IL------------------V-------------------GVNKDEGTA------------------FL-------VYGAPG-FSKD--NNSIIT---------RKEF----------------------QEGL-KIFF-------PGV----------------------SEFGK-E---------SILFHY----TDWVDD---------------------------------------Q---RP-ENYR----------------E---ALGDV-----VG-D------------------------------YNFICP----ALEFTKKF-SEW-----GN------------------------------N--AFFYYF-------EH-RSSKLPW-------P--EWM--------G-VMHG---------YEI-EFVFG------LPLE--RR-DNYTKA--------------------------- 590
591 NPNTNLSEDC--------------------LYLNVWI-----R-VPKP--------------------KN--A-TVMVW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FQT-GT------SS------L--PVYDGKFLAR-----VE----RVIVVS------M-N---YR-VG-------------ALGFLAF-------PGNPD---A-----P-G---NMGLFD--QQLA----------------------------------------------L-----------------------------Q--WVQRN-----------------------------IAAFG---------------------GN------------------------------------------------------PKS----I-TI--F-G--ES-----------------AG-----------------------------A-ASVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLCPQ-------S---------------Y---------------PLFTRAILE-----------------------------------------------------------------------------------------S-GSSN---------APWAVKH---PEE---A---------------------------RNRTL---------TLA----KFTGC----------------------------------------------------------SK----ENEM---------------------------------------EMIK---CLR---S------K------------------------------------------------DPQEILRN----E-RFVLPSDS---------------I-LSINFG----------------------------P------TV----DG--------------D--FL----TDMPH-TL------------------------------------------LQLGK------V-KK---------------------------------------------------------------------------------------------------------------------------AQ--IL------------------V-------------------GVNKDEGTA------------------FL-------VYGAPG-FSKD--NDSLIT---------RKEF----------------------QEGL-NMYF-------PGV----------------------SRLGK-E---------AVLFYY----VDWLGE---------------------------------------Q---SP-EVYR----------------D---ALDDV-----IG-D------------------------------YNIICP----ALEFTKKF-AEL-----EN------------------------------N--AFFYFF-------EH-RSSKLPW-------P--EWM--------G-VMHG---------YEI-EFVFG------LPLG--RR-VNYTRA--------------------------- 591
592 NPNTDLNEDC--------------------LYLNIWV-----P-SPKP--------------------KN--T-TVMVW----I-------Y---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FQS-GT------SS------L--NVYDGKFLAR-----VE----RVIVVS------M-N---YR-LG-------------AFGFLAL-------PGNEE---A-----P-G---NAGLFD--QRLA----------------------------------------------L-----------------------------Q--WIQDN-----------------------------IVAFG---------------------GN------------------------------------------------------PKS----V-TL--F-G--ES-----------------AG-----------------------------A-GCISY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-MLSPQ-------S---------------H---------------PLFTRAILQ-----------------------------------------------------------------------------------------S-GAGN---------APWGVIL---PSE---A---------------------------RRRTL---------ALA----QLLHC----------------------------------------------------------TS----SNET---------------------------------------EIIS---CLQ---N------K------------------------------------------------DPQDILDK----Q-VSVLKHSA---------------I-LELYFT----------------------------P------VV----DN--------------D--FL----ADTPA-AL------------------------------------------LRSGK------F-KQ---------------------------------------------------------------------------------------------------------------------------TQ--IL------------------M-------------------GVNKDEGAP------------------FL-------AYGAPG-FNKD--NSSLIN---------ETEF----------------------WACL-RLTF-------PET----------------------QEIGL-E---------AVAFHY----TDWEEE---------------------------------------Q---DP-FRYR----------------N---VMGEI-----LG-D------------------------------YNFICP----VLEFLKYF-IKT-----GN------------------------------S--AFLYFF-------EH-RSSKLAW-------P--EWM--------G-VPHG---------YEI-EFVFG------LPLE--RR-VNYTKA--------------------------- 592
593 NPKTNLSEDC--------------------LYLNVWI-----P-SPKP--------------------KN--A-TVMVW----I-------Y---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------FET-GS------TS------L--PVYDGKFLAR-----VE----RVIVVS------M-N---YR-TG-------------ALGFLAL-------PGNKE---V-----P-G---NAGLFD--QRLA----------------------------------------------L-----------------------------Q--WVQEN-----------------------------IASFG---------------------GN------------------------------------------------------PKS----V-TI--F-G--ES-----------------AG-----------------------------S-ASVSY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-ILSPK-------S---------------H---------------PLFTRAIMQ-----------------------------------------------------------------------------------------S-GSAN---------APWAAIT---ASE---A---------------------------RRRTV---------ALA----KQLKC----------------------------------------------------------PT----SDET---------------------------------------ELIL---CLQ---D------K------------------------------------------------DPKDILEN----E-VYVVKYFS---------------L-LHIYFC----------------------------P------TV----DG--------------D--FL----ADMPE-AL------------------------------------------IKNGI------F-KQ---------------------------------------------------------------------------------------------------------------------------TQ--VL------------------V-------------------GVNKDEGTS------------------FL-------VYGVPG-FSKD--SDSLIN---------KTQF----------------------EVAL-TLSF-------PQV----------------------SKLAI-E---------SIIFQY----TDWENE---------------------------------------Q---KP-EHYR----------------D---AMDDV-----IG-D------------------------------YHIICP----AVEFAKTI-AEV-----GN------------------------------N--VFFYFF-------EH-RSSKLPW-------P--EWM--------G-VMHG---------YEI-EFVFG------LPLE--RR-VNYTKA--------------------------- 593
594 -PNTALSEDC--------------------LHLNIWV----------P-----------EVSAG---SA---KLTTMVW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FVT-GT------ST------L--DVYNGAMLAA-----LQ----NVIVVS------M-N---YR-LG-------------PLGFLYL--------DTEE---A-----P-G---NMGLLD--QQLA----------------------------------------------L-----------------------------Q--WIHSN-----------------------------VVYFG---------------------GS------------------------------------------------------PQD----L-TL--F-G--ES-----------------AG-----------------------------A-ASVAY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-MMAND-------S---------------R---------------DLFHSAILQ-----------------------------------------------------------------------------------------S-GSSL---------AHWAYNS------PEVS---------------------------LKYAE---------NLA----KAFDC----------------------------------------------------------ESP----------------------------------------------NRKSMISCLRD--V-------------------------------------------------------DAGELSKRMFYLS-ITPVTFNFV--------------------------------------------------P------TI----DN--------------Q--FI----YESPS-KF------------------------------------------INSGH------F-PA---------------------------------------------------------------------------------------------------------------------------KK--LL------------------L-------------------GVNRNEALY----------------------------FLFYAIYAEMEWPNNTLS---------QSNY----------------------MKIL-------------------------------PLALSNNGFEKLEIKKDKLVIDAILDRY-----------------------------------------------ESNLLPGDTRDYL----------------M---ILDDI-----IG-D------------------------------FAFKCP----VIQLAQNYAKSP-------------------------------------GSSVYFYEF-------NH-RPSVSDW---------PAWS--------G-SLHG---------DEV-QFLFGLTLKPEAAYTMDE----------------------------------- 594
595 NPNTNMSEDC--------------------LYLNIWA--------PSD-----------R-A-K---GET--K-AVMLW----I-------F---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------FTL-GS------NT------L--DVYDGRILAA-----QG----DVVVVS------M-Q---YR-VG-------------ALGFLFL--------DDIG---A-----P-G---NMGLLD--QHVA----------------------------------------------L-----------------------------R--WVYDY-----------------------------IEAFG---------------------GD------------------------------------------------------RNR----I-TL--F-G--ES-----------------AG-----------------------------A-ASASF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLAPS-------S---------------R---------------PFFKSSILQ-----------------------------------------------------------------------------------------S-ASAL---------SPWAVSS---NET---A---------------------------IERSL---------STA----SLVNC----------------------------------------------------------DR------NA---------------------------------------PTAEVLKCLK---S------A------------------------------------------------SAQEISEQ----M-WSIPGDLR---------------N-IIAPIS----------------------------P------IV----DG--------------Y--FI----QEQPL-DT------------------------------------------LKKGD------V-KN---------------------------------------------------------------------------------------------------------------------------SD--IL------------------L-------------------GMNQDEGTY------------------FL-------VYTFQTLYNLT-YEDRIVS---------QKEF----------------------RKALGNFI--------KNV----------------------PSDVV-D---------LIAFEY-GTAVNW------------------------------------------H---EG-VVFK----------------D---AMDDV-----LG-D------------------------------YAFKCP----VVDFANHY-ASH-----GN------------------------------D--VFMYNF-------KH-RTSANPW-------P--SWL--------G-TMHG---------YEI-DHVFG------APLN--TS-RQYT----------------------------- 595
596 ---TPLSEDC--------------------LYINVVA-----P-RPRP--------------------KN--A-AVMLW----I-------F---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FYS-GT------AT------L--DVYDHRALAS-----EE----NVIVVS------L-Q---YR-VA-------------SLGFLFL--------GTPE---A-----P-G---NAGLFD--QNLA----------------------------------------------L-----------------------------R--WVRDN-----------------------------IHRFG---------------------GD------------------------------------------------------PSR----V-TL--F-G--ES-----------------AG-----------------------------A-VSVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSAL-------S---------------R---------------DLFQRAILQ-----------------------------------------------------------------------------------------S-GSPT---------APWALVS---REE---A---------------------------TLRAL---------RLA----EAVGC----------------------------------------------------------PH----EPS----------------------------------------KLSDAVECLR---G------K------------------------------------------------DPHVLVNN----E-WGTL-G-----------------I-CEFPFV----------------------------P------VV----DG--------------A--FL----DETPQ-RS------------------------------------------LASGR------F-KK---------------------------------------------------------------------------------------------------------------------------TE--IL------------------T-------------------GSNTEEGYY------------------FI-------IYYLTELLRKE--EGVTVT---------REEF----------------------LQAVRELN--------PYV----------------------NGAAR-Q---------AIVFEY----TDWTEP---------------------------------------D---NP-NSNR----------------D---ALDKM-----VG-D------------------------------YHFTCN----VNEFAQRY-AEE-----GN------------------------------N--VYMYLY-------TH-RSKGNPW-------P--RWT--------G-VMHG---------DEI-NYVFG------EPLN--PT-LGYTEDE-------------------------- 596
597 NSPVRLSEDC--------------------LNLNVWT-----P-YPRP--------------------QA--A-TVMIW----I-------Y---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------FLS-GV------SS------L--DVYDGQYLAA-----EQ----NVVVVS------M-N---YR-LG-------------ALGFLAM--------GQDS---S-----P-G---NQGLMD--QTLA----------------------------------------------M-----------------------------R--WVQDN-----------------------------IHEFG---------------------GD------------------------------------------------------PNQ----V-TI--F-G--ES-----------------AG-----------------------------A-ASVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPI-------S---------------R---------------NLFQRAIMQ-----------------------------------------------------------------------------------------S-SAAT---------APWATVD---HDE---G---------------------------LRRGK---------LLA----EKLQC----------------------------------------------------------SE----GNNGVELTI---------------------------------PQMVD---CIR---T------R------------------------------------------------EVTQILLK----Q-FEITDG-----------------F-CEFPFP----------------------------P------VV----DG--------------T--FI----TETPR-TS------------------------------------------LERRS------F-KD---------------------------------------------------------------------------------------------------------------------------GE--IM------------------L-------------------GSNLNEAYF------------------FI-------IYEVPG-FDKD--SESLLN---------RDQF----------------------YDAL-QYSF-------PRV----------------------NSFGQ-D---------AIAFQY----TEWLAP---------------------------------------H---DP-VKLR----------------D---GVDFA-----AG-D------------------------------YLFACS----TYDFAYSY-ASA-----NN------------------------------K--VYYYRF-------LE-RDSTSPW-------P--DWM--------G-VLHG---------DEI-LYIFG------MPLI--AE-RNYTDIE-------------------------- 597
598 NPNRPLSEDC--------------------LFLNIWV-----P-HPQP-----------S-VP---------I-PILVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FVA-GT------SS------L--DLYNGASLAA-----TE----NVIVAS------M-N---YR-LG-------------ALGFLSL-------PPA-----V-----P-G---NMGLWD--QHLA----------------------------------------------L-----------------------------T--WIKQN-----------------------------AAAFG---------------------GD------------------------------------------------------PKR----V-TI--F-G--HS-----------------AG-----------------------------A-ASVGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPK-------S---------------E---------------PLFAQAVLQ-----------------------------------------------------------------------------------------S-GAI------------YASAS---PGK---A---------------------------KNNSL---------EFS----QLLGC----------------------------------------------------------GEGNENE----------------------------------------------IVSCLQ---D------K------------------------------------------------NAVEFP-Q---HE-AS--LSKK------------KPL---YPVFE----------------------------P------TA----DG--------------E--FL----TDDPQ-SL------------------------------------------LDSQH------V-QI---------------------------------------------------------------------------------------------------------------------------KP--VL------------------T-------------------GVASDEAAP------------------IV-------DLIILG---SN--YS-QIN---------MEIF----------------------LTVL-RYLV-------RNA----------------------TEDDI-Q---------AMALKY-----S-EES---------------------------------------H---GP-AKYR----------------S---ALVQS-----LG-D------------------------------YFFVCP----VAKFAGQI-RNV-----G-------------------------------SP-VYVYLF-------TH-HTSGTVW------PE---WV--------G-VPHG---------AEL-IYLFG------------------------------------------------ 598
599 NPNRPLSEDC--------------------LFLNIWV-----P-HPQP-----------S-VP---------I-PILVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FVA-GT------SS------L--DLYNGASLAV-----TE----XVIVAS------M-N---YR-LG-------------PLGFIYL-------PPA-----V-----P-G---NMGLWD--QHLA----------------------------------------------L-----------------------------T--WIKEN-----------------------------AAAFG---------------------GD------------------------------------------------------PKR----V-TI--F-G--HS-----------------AG-----------------------------A-ASVGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPK-------S---------------E---------------PLFAQAVLQ-----------------------------------------------------------------------------------------S-GVP------------ISWLN---PEN---A---------------------------KNKSL---------ELS----QLMGC----------------------------------------------------------GEGNENE----------------------------------------------IVSCLQ---E------K------------------------------------------------NAKEFP-Q---YE-TALFLKNK------------FLL---DPIFA----------------------------P------IA----DG--------------E--FL----TDDPQ-SL------------------------------------------LNSQR------V-QI---------------------------------------------------------------------------------------------------------------------------KP--VL------------------T-------------------GVTSDEAAS------------------LV-------DFISRV---NN--HS-QIT---------REHF----------------------LNVL-RITL-------RNA----------------------TEEDI-Q---------AVALKY-----S-KES---------------------------------------H---GP-AKYR----------------S---AVVQS-----LG-D------------------------------YFFVCP----AAKFAGQI-RKA-----G-------------------------------SP-VYVYIF-------TH-HTSGTVW------PE---WA--------G-APHG---------AEL-IYLFG------------------------------------------------ 599
600 NPNRPLSEDC--------------------LFLNIWV-----P-HPQP-----------S-VP---------I-PILVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FIS-GT------SS------L--DLYNGSSLAV-----TQ----NVIVAS------M-N---YR-LG-------------ALGFLSL-------PPA-----V-----P-G---NMGLWD--QHLA----------------------------------------------L-----------------------------T--WIKQN-----------------------------AAAFG---------------------GD------------------------------------------------------PKR----V-II--F-G--QS-----------------SG-----------------------------A-ASVGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPK-------S---------------E---------------SLFAQAVLQ-----------------------------------------------------------------------------------------S-GAPN---------AIWAWAS---PEQ---A---------------------------KNKSL---------ELS----QLLGC----------------------------------------------------------GEGNENE----------------------------------------------IVNCLR---G------K------------------------------------------------NAMEFP-P---YE-TLLVLKSK------------FLM---CLPFI----------------------------P------TT----DG--------------E--FL----TDDPQ-SL------------------------------------------LDSQH------V-QT---------------------------------------------------------------------------------------------------------------------------KP--IL------------------T-------------------GVNSDEAAS------------------LL-------TFIFPG---SN--HS-LIN---------HEQF----------------------LKVL-RSAL-------QNA----------------------TEEEI-Q---------AVALKY-----S-EES---------------------------------------H---GP-AKYR----------------S---ALVQS-----LG-D------------------------------YLFVCP----ATEFAAKI-RKA-----G-------------------------------SP-VYVYYF-------TH-HTSGTVW------PE---WA--------N-ATHG---------AEL------------------------------------------------------ 600
601 VAKKPHSEDC--------------------LFLNIWV-----P-DPRP-----------S-TP---------V-PVLLW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FVA-GA------SS------L--DLYNGAFLAA-----AE----NVIVAS------M-N---YR-LG-------------VLGFLFL-------PPE-----A-----P-G---NMGLWD--QNLA----------------------------------------------M-----------------------------K--WIKEN-----------------------------AAAFG---------------------GD------------------------------------------------------PAH----L-TL--L-G--HS-----------------AG-----------------------------A-ASVGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPA-------S---------------Q---------------PLFTHAVIQ-----------------------------------------------------------------------------------------S-GLPN---------APWAWRH---PNE---S---------------------------MWAAM---------KLS----EILNC----------------------------------------------------------EQGNHSDMES---------------------------------------CLHNVMNCLR---K------A------------------------------------------------NP----------------EKDE------------FYL---VEKFQG---------------------------P------TL----DG--------------D--FL----PAEAE-KL------------------------------------------KETGL------S-HD---------------------------------------------------------------------------------------------------------------------------KP--LL------------------L-------------------GITRDEGSI------------------FT-------VFANSNI-LNN--GG-ILT---------WEEL----------------------VQAI-NMVF-------HQK----------------------VEDSIVK---------ALAKKY-----S-EDT---------------------------------------H---GP-GQYH----------------S---ALSHL-----YR-D------------------------------YYFLCP----LVEVTSKM-GTS-----G-------------------------------SP-VYVYSF-------NH-PISGPLW------PE---WM--------G-APHG---------VEV-PYLFG------------------------------------------------ 601
602 DPIPSVSEDC--------------------LFLNIWV-----P-YPLP-----------M-GP---------A-AVLVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FFM-GT------GS-----------YDKSLLAA-----TE----NIIVAS------L-N---YR-LG-------------ALGFLAL-------PPG-----A-----P-G---NAGLWD--QHLA----------------------------------------------L-----------------------------H--WLKDN-----------------------------IAAFG---------------------GD------------------------------------------------------PTR----L-TL--G-G--QS-----------------AG-----------------------------S-ASVGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPV-------S---------------Q---------------PVFAQATLQ-----------------------------------------------------------------------------------------S-GAAI---------SPWAWVS---PEE---A---------------------------KARGR---------HLG----QMLGC----------------------------------------------------------AENDDKG----------------------------------------------VVNCLQ---R------K------------------------------------------------DPGEV------MR-KLPGTEPR------------NLI---TTIFV----------------------------P------TT----DG--------------E--FL----PDDPR-NL------------------------------------------LEARS------F-PL---------------------------------------------------------------------------------------------------------------------------KP--IL------------------T-------------------GFTTEEGTL------------------FL-------MDNAPGLSISN--ES-LIN---------HKQL----------------------LQGL-RLVA-------PKA----------------------SQCAI-Q---------AAAFLY-----T-LGN---------------------------------------N---GK-ERYR----------------N---AMVKA-----AG-D------------------------------HMFLCS----VAEVATQM-AKA-----G-------------------------------SP-VFAYVF-------TH-HPPYAGA------PD---WI--------G-ATHC---------AEL-PYMVG--------------NILSLTRSNLTDPE-------------------- 602
603 ------------------------------------V----------P-----------EDHDG----------SVMVW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FFS-GT------PS------L--DLYSGSVFAA-----KE----HTIVVN------V-N---YR-LG-------------PFGFLYF--------G-DDSPIQ-------G---NMGLMD--QQLA----------------------------------------------L-----------------------------K--WVHEN-----------------------------IGAFG---------------------GD------------------------------------------------------RSR----V-TL--F-G--ES-----------------AG-----------------------------S-TSATA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LFAPN-------S---------------H---------------KYFRNIIAK-----------------------------------------------------------------------------------------S-GSII---------NSWASAP------PPTM---------------------------LDLSF---------RLA----KKVNC----------------------------------------------------------SST----------------------------------------------DMNVVAKCLRS--V-------------------------------------------------------PAHLVQAEADNIS-GDIGPPMTFAYVP----------------------------------------------V------SS----DA--------------N--FF-----QGDVIQK------------------------------------------LNNKQ------F-KK---------------------------------------------------------------------------------------------------------------------------DVN-II------------------F-------------------GSVKDEGTYW-------LP-------YYM-SLPKYGFAFNHTISAEDPHNRALIT---------REHY----------------------EESMKAFMPY---FAGSKLVLN-----------------------------------AFMNSY-----------------------------------------------------EHVSTSNVPE---------ERYRD---GVARF-----LG-D------------------------------LFFTCS----LIDFADLISDNI------------------------F-------------GNVYMYYF-------TY-RSSANPW---------PRWM--------G-VMHG---------YEI-EYAFG------QPYWRPHLYDQKQLEDE------------------------- 603
604 ------------------------------------V----------P-----------EDHDG----------SVMVW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FFS-GT------PS------L--DLYSGSVFAA-----KE----HTIVVN------V-N---YR-LG-------------PFGFLYF--------G-DDSPIQ-------G---NMGLMD--QQLA----------------------------------------------L-----------------------------R--WVHEN-----------------------------IGAFG---------------------GD------------------------------------------------------RSR----V-TL--F-G--ES-----------------AG-----------------------------S-ASTTA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LFAPN-------S---------------H---------------KYFRNIIAK-----------------------------------------------------------------------------------------S-GSII---------NSWASAT------PPTM---------------------------LDLSF---------RLA----KKVNC----------------------------------------------------------SSP----------------------------------------------DMNAIVKCLRS--V-------------------------------------------------------PAHLVQAEADNIS-GDIGPPMTFAYVP----------------------------------------------V------SS----DA--------------N--FF-----QGDVFQK------------------------------------------LANKQ------F-KK---------------------------------------------------------------------------------------------------------------------------DVN-II------------------F-------------------GSVKDEGTYW-------LP-------YYM-SLPKYGFAFNHTISAEDPHNRALIT---------RDHY----------------------EESMRAFMPY---FAGSKLVLN-----------------------------------AFMNSY-----------------------------------------------------EHVSTSNVPE---------ERYRD---GVARF-----LG-D------------------------------LFFTCS----LIDFADLISDNI------------------------F-------------GNVYMYYF-------TY-RSSANPW---------PKWM--------G-VMHG---------YEI-EYAFG------QPYWRPHLYDQTHLEDE------------------------- 604
605 FRDPGNSEDC--------------------LSLNVWA----------P-----------PAKKH---D----KLPVMVW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------YIT-GG------TS------E--PRQDGTNLAH----------KGVILVS------M-N---YR-LG-------------IFGFFAGSGLAKESPHHAA-----------G---NYGLMD--QSLA----------------------------------------------L-----------------------------H--WVHDN-----------------------------IAKFG---------------------GD------------------------------------------------------PNN----V-TI--F-G--ES-----------------AG-----------------------------S-MSVST---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-MAAPS-------S---------------Q---------------GMFARAAGE-----------------------------------------------------------------------------------------S-GGAF---------GNLTYPSLASAEKKDDA---------------------------FMRKA--------------------------------------------------------------------------------------------------------------------------------FGTDDIAKLRK--V-------------------------------------------------------SADALLKAEVNPA-YGRVGFM----------------------------------------------------P------DI----DG--------------W--YL----PQTVP-AI------------------------------------------FAEGK------Q-AH---------------------------------------------------------------------------------------------------------------------------VP--LL------------------A-------------------GWNRDEGSFS-------ML-------GHP------PTTLDSFEAFAHKAFETNAD--------------------------------------------------------------------------------------------AFLKAY--------------------------------------------------AASNDQEAAR--------------------ARLDF-----AG-D------------------------------NFIAYS----TWAWIEGQVKTG-------------------------------------DAPVYRYYF-------ALGSPGDMVH---------PASL--------G-AFHS---------DDI-EYVFGNLDSRRGAHWR------------------------------------- 605
606 DVNAPISEDC--------------------LYLNVWS-----P-FPTP--------------------SK--A-AVMVW----I-------P---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LTS-GA------SS------V--DLYDGATLAD-----AE----QVIVVS------V-N---YR-LG-------------VLGFLAL--------RDTQ---A-----P-G---NMGFLD--QAMA----------------------------------------------L-----------------------------Q--WVADN-----------------------------IDYFG---------------------GD------------------------------------------------------PER----V-TI--F-G--ES-----------------AG-----------------------------A-ISVGV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LFS---------S---------------Q---------------NLFRRAILQ-----------------------------------------------------------------------------------------S-GNVF---------FPESIVT-------------------------------------YDRSE---------KLALTMTDNLGC----------------------------------------------------------GLNYLSNETV---------------------------------------DNTKILECFN---S------K------------------------------------------------STEEIVLA----Q-YV------------------DDVR-IPTP------------------------------G------VV----DG--------------T--FL----KDSPL-NL------------------------------------------LKDGL------Y-ES---------------------------------------------------------------------------------------------------------------------------TE--IL------------------I-------------------GDNLNEGTW------------------FL-------PYMAPQYFSLD--QKPILN---------HTTF----------------------EEFI-EFYF-------SMA----------------------NALTH-A---------AISFEY----TNWLEP---------------------------------------E---NS-ADLV----------------A---GASDV-----VG-D------------------------------FLITCP----TDETAKLY-SQY-----GN------------------------------D--VYRYLF-------SE-LASNTPW-------L--DWY--------G-VLHG---------DEI-PFVFG------TPLY--PE-NGFSDSE-------------------------- 606
607 NANVPVSEDC--------------------LFLNVWT-----P-YPRP--------------------LR--T-AVMVW----I-------Y---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FVS-GT------AS------L--DVYNGQALAA-----ME----NVVVVS------M-N---YR-VG-------------ALGFLSL--------MDPE---I-----P-G---NMGFMD--QALS----------------------------------------------L-----------------------------Q--WVRDN-----------------------------IEAFG---------------------GD------------------------------------------------------PYQ----V-TI--F-G--ES-----------------AG-----------------------------G-VSVGM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LMSPM-------S---------------Q---------------HLFQRAILQ-----------------------------------------------------------------------------------------S-GTPL---------SPWATLT---EIE---A---------------------------IDRAK---------EFA----NNLGC----------------------------------------------------------QYD---EDQF---------------------------------------SASELTACFL---Q------K------------------------------------------------DAEEIYNA----Q-WV------------------GNSL-IGMPFM----------------------------T------VV----DG--------------V--FL----TQTPQ-NL------------------------------------------MKDGL------F-KN---------------------------------------------------------------------------------------------------------------------------VP--IL------------------L-------------------GSNKDEGTW------------------FL-------PYHFYDLFSLD--DPAPLD---------KTTF----------------------QRIIKELYI-------S-A----------------------KALTR-K---------SIAFEY----TDWYDP---------------------------------------D---NA-DHVL----------------K---NIANM-----LG-D------------------------------SEITCP----TVEFAKLY-A-------GN------------------------------DIPVFLYHF-------TH-RSTNNPW-------P--EWY--------G-CLHG---------DEI-AYVFG------LPRT--TE-DEY------------------------------ 607
608 NPNVLLDEDC--------------------LYLNVWT-----P-HPRP--------------------TN--A-AVMVW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FVA-GV------AS------L--EVYHGATLAA-----TE----GTIVVS------F-N---YR-VA-------------SLGFFYL--------GHED---A-----P-G---NIGLLD--QVLA----------------------------------------------L-----------------------------Q--WVQDN-----------------------------IIHFG---------------------GD------------------------------------------------------PTR----V-TI--F-G--ES-----------------AG-----------------------------S-VSVGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPV-------S---------------R---------------NLFARAILQ-----------------------------------------------------------------------------------------S-GTPN---------NPWATVT---ADE---A---------------------------RRRSL---------KLS----KELGC----------------------------------------------------------YNEHSMTNNE---------------------------------------DIAL---CMR---R------Q------------------------------------------------DARDLISS----E-WF----DD------------MHGI-YRFPFI----------------------------P------VV----DG--------------T--FL----TETPQ-SS------------------------------------------LERHA------F-KP---------------------------------------------------------------------------------------------------------------------------TS--VM------------------L-------------------GTNKDEGPF------------------FI-------IYYVPE-FRYD--NESLID---------RSVY----------------------KKAI-DIGF-------KHL----------------------NKFGR-D---------AVAFRY----INWWDT---------------------------------------N---EG-AMLR----------------D---GFSNM-----IG-D------------------------------ENIHCP----AQEFAYSY-ATG-----QE------------------------------D--VYLYYF-------TQ-RASNSLF-------H--PWM--------G-VLHG---------DEI-AYVFG------LPLH--EQ-GNYS----------------------------- 608
609 -SKQPLSEDC--------------------LNLNVWT-----T-HPRP--------------------EN--A-AVMVW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FYS-GT------SG------L--DVYNGKYLAA-----EE----GVIVVS------L-N---YR-LG-------------PLGFLYL---------HEH---T-----P-G---NMGLLD--QVLA----------------------------------------------L-----------------------------Q--WVQDN-----------------------------IINFG---------------------GD------------------------------------------------------PTR----V-TI--F-G--ES-----------------AG-----------------------------S-VSVGM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPL-------S---------------R---------------DLFNYAILE-----------------------------------------------------------------------------------------S-GTPN---------NPWASVS---LEL---A---------------------------TDRAS---------RLA----LAVGC----------------------------------------------------------Y-------NG---------------------------------------DFSIMLSCLR---Q------V------------------------------------------------GPQELVNN----Q-WE----D--------------YGV-YVFPFV----------------------------P------VV----DG--------------T--FL----TETPQ-SS------------------------------------------LDRHS------F-KN---------------------------------------------------------------------------------------------------------------------------TS--IL------------------I-------------------GSNLNEGNF------------------FL-------IYGTSG-FNAF--TDSLLN---------HSLY----------------------QQAT-KESF-------QDY----------------------NQFGL-D---------AISFQY----IDWMDP---------------------------------------D---ND-TMLR----------------N---AVDAM-----VG-D------------------------------YNIICP----ANQFATSY-ARV-----QQ------------------------------T--VYKYYF-------TQ-VSSNSPW-------R--DWL--------G-SLHG---------DEI-AYVFG------IPLD--IS-TGFSTQE-------------------------- 609
610 NPNTPVNEDC--------------------LYLNVWV--------PKA-----------T-E-S----RN--K-SVMVW----I-------Y---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------FSY-GS------IS------L--DVYNGKYLAV-----EN----DVIVVS------I-Q---YR-LG-------------SLGFFVS--------NSPD---A-----P-G---NCGLFD--QLMG----------------------------------------------L-----------------------------D--WVQRN-----------------------------IHYFG---------------------GS------------------------------------------------------PND----V-TL--F-G--ES-----------------SG-----------------------------A-ASIGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPL-------S---------------R---------------FKFQRAILQ-----------------------------------------------------------------------------------------S-AGPE---------APWATIT---KEE---A---------------------------IERG----------KVLV---RKLNC----------------------------------------------------------TK------DS---------------------------------------D-VDTLECLR---L------V------------------------------------------------PANKFPPN----D-FI----LD-------------ANI-LQFPFV----------------------------P------II----DG--------------V--FL----IERPD-DS------------------------------------------FHNGN------F-KR---------------------------------------------------------------------------------------------------------------------------CP--IL------------------L-------------------GANKNEGSY------------------FL-------VYGAEG-FNKS--HSSPVK---------SSEF----------------------KLKL-DKQFRHFPQYPTES----------------------NKFVL-D---------AIAFQY----TPWTDP---------------------------------------N---DP-YLLR----------------D---GIEAA-----VG-D------------------------------YSFTCP----TVDLAREY-AQV-----GQ------------------------------N--VYFYLF-------NH-RSSVNPW-------G--EWM--------G-VMHG---------DEI-MFIFG------QPLD--NN-FNYETK--------------------------- 610
611 ------SEDC--------------------LYLNIWT------PNPKP-----------T------------NAPVMVW----F-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FVI-GS------SS------K--LGYEGHALSG-----YH----GVILVN------T-N---YR-LN-------------GFGFLST--------GDDV---L-----P-G---MYGMYD--QLEA----------------------------------------------L-----------------------------K--WVQKN-----------------------------IGAFG---------------------GD------------------------------------------------------PDQ----V-TI--F-G--QS-----------------AG-----------------------------A-GSVGI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-LLSPE-------S---------------E---------------PYFQRAILV-----------------------------------------------------------------------------------------S-GTAT---------SPWAVET---------D---------------------------ATKAR---------NDAFGVGEAARC----------------------------------------------------------DDLS---------------------------------------------SSQALADCLRG--L-------------------------------------------------------PEKTLTFAIDRIL-LETTNVIPFV-------------------------------------------------P------TV----DG--------------D--FL----PDNPL-SL------------------------------------------VKANR------F-KK---------------------------------------------------------------------------------------------------------------------------CP--IM------------------L-------------------GATKDDGSLI-------AA-------RAF------LRQINTDEGYAN-----------------RTEF----------------------RDALERFTYTYVNDVIVD---------------------------------------SIMQEY----VDWTIA-------------------------------------------DDPEA------------------NYFYDYIAV-----QT-D------------------------------EAFACP----SVDFARYY-AEE-------------------------------------GQDVYLYDF-------TH-LPNQTVW---TSELASPGWK--------G-VAHA---------EDL-QFIFG------------------------------------------------ 611
612 NTEGPQSEDC--------------------LYLNIWT----------P-----------Q-HPR---HKT--PLPVLVW----I-------H---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------FVT-GS------GS------L--AVYNGTTLAA-----VE----QVIVVT------L-N---YR-LN-------------TFGFLAL-------ENTDS---------P-G---NMGLMD--QVMA----------------------------------------------L-----------------------------Q--WIHDN-----------------------------IQFFN---------------------GN------------------------------------------------------HDQ----V-TL--F-G--AS-----------------AG-----------------------------A-ASVGY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-ILSPS-------S---------------R---------------RLFKRAILQ-----------------------------------------------------------------------------------------S-GSPM---------MPFLSPG---TYTE--H---------------------------RHLAK---------CMA----FSLGC----------------------------------------------------------LTK------------------------EELSYEFNVSV---------------VLKCLR---N------L------------------------------------------------PP-DKLA----NS-YNL-IHF----------------------------------------------------P------VQ----DD--------------R--FI----LSQPA-DS------------------------------------------LNNME------L-KR---------------------------------------------------------------------------------------------------------------------------TQ--VL------------------L-------------------GANENEGMFN-------LI-------RL-------------------------IPDF-SLDTDSHITY-----------------------EKYLETIGFRFGELPSEVLD------------------------------------QIGEEY----VRQHDK-------------------------------------------EDGESLR----------------D---LADNT-----WG-D------------------------------YDIICP----TVEFANEYHALV-------------------------------------NEDVFLYNF-------QH-RSSHNPW---------PEWA--------G-TVHA---------DEI-AYVFG------VPLHND-QLYSEDD---------------------------- 612
613 NANTPVSEDC--------------------LYVNIWA----------P-----------ADAYN---------LTVLVW----L-------F---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FWY-GS------PS------L--LLYDGKELAT-----RG----NVIVVN------I-N---YR-VG-------------PFGYLYL--------GHDDVP---------G---NMGMLD--QQLA----------------------------------------------L-----------------------------Y--WIRDH-----------------------------IFSFG---------------------GN------------------------------------------------------PSR----I-SL--V-G--ES-----------------AG-----------------------------A-ASIVA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LIAPA-------S---------------K---------------GLFQNGILQ-----------------------------------------------------------------------------------------S-GSLD---------NKWSMDS------PKRA---------------------------KQKST---------ALA----NLVGC----------------------------------------------------------NQT----------------------------------------------KITDVTECLR---N-------------------------------------------------------TPAQLL--IDNIW-NVGLNFLEFPFAI----------------------------------------------V------SK----DR--------------N--FF----KHLDGFIA------------------------------------------LREGT------Y-ST---------------------------------------------------------------------------------------------------------------------------DVN-LM------------------F-------------------GINHDEGNFW-------NI-------YNL---AKF---------FDKKTAKPELD---------RDEF----------------------HECVDTAFAV-----QPELVRT-----------------------------------AAKYVY-----------------------------------------------------SDPKCTDPKKKT-------DFYTE---QVNQM-----VG-D------------------------------YFFTCD----SIWFAHNY----------------------------------PKLA-GNRSNVFVYYF-------DQ-PSSANPW---------LKWT--------G-VMHG---------YEI-EYVFG------VPLHNK-SAGYIK----------------------------- 613
614 NANTPVSEDC--------------------LYVNIWA----------P-----------ADAYN---------LTVLVW----L-------F---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FWY-GS------PS------L--LLYDGKELAT-----RG----NVIVVN------I-N---YR-VG-------------PFGYLFL--------DQEDVP---------G---NMGMLD--QQLA----------------------------------------------L-----------------------------Y--WIRDH-----------------------------IFSFG---------------------GN------------------------------------------------------PAR----I-SL--V-G--ES-----------------AG-----------------------------A-ASIVA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LIAPA-------S---------------K---------------GLFQNGILQ-----------------------------------------------------------------------------------------S-GSLD---------NKWSMDS------PKRA---------------------------KQKST---------ALA----DLVGC----------------------------------------------------------NQT----------------------------------------------KITDQTACLR---N-------------------------------------------------------TPAQLL--IDNIW-NVGLNFLEFPFAI----------------------------------------------V------SK----DQ--------------N--FF----KHLDGFIA------------------------------------------LREGT------Y-ST---------------------------------------------------------------------------------------------------------------------------DVN-LM------------------F-------------------GINHDEGNFW-------NI-------YNL---AKF---------FDKQSVKPGLD---------RDEF----------------------HECVDTAFAV-----QPELVRT-----------------------------------AAKYVY-----------------------------------------------------SDPKCTDPKKKT-------DFYTE---QVNQM-----VG-D------------------------------YFFTCD----SIWFAHNY----------------------------------PKMA-GNQSNVFVYYF-------DQ-PSSANPW---------PKWT--------G-VMHG---------YEI-EYVFG------VPLHNT-TAGYTK----------------------------- 614
615 NANTQISEDC--------------------LYLNIWA----------P-----------ADAYN---------LTVMVW----F-------F---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FYS-GS------PS------L--SIYDGKALTS-----TQ----NVIVVN------I-N---YR-LG-------------PFGFLYL--------GHPDAP---------G---NMGLLD--QQLA----------------------------------------------L-----------------------------H--WVRQN-----------------------------IVSFG---------------------GN------------------------------------------------------PDK----V-AV--F-G--QS-----------------AG-----------------------------A-ASIVA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LIAPG-------S---------------R---------------GLFKNAILQ-----------------------------------------------------------------------------------------S-GSLE---------NTWAINS------PFRA---------------------------KQKSE---------KLL----ELVGC----------------------------------------------------------NKT----------------------------------------------TVDTSMACLRL--V-------------------------------------------------------SPEQLS--L-STW-NISLTYLEFPFVI----------------------------------------------V------SR----DK--------------H--FF----GHLDAHAA------------------------------------------LREGD------F-NR---------------------------------------------------------------------------------------------------------------------------DVN-LM------------------I-------------------GMNKDEGNYW-------NI-------YQL---PQF---------FDKAD-PPELN---------RTEF----------------------DFLIDRTFSI-----QPDIIRS-----------------------------------AAKYIY-----------------------------------------------------SDPNCTDHGRKT-------RFYAG---QMNQI-----VG-D------------------------------YFFSCD----SLWLADQFRSIP------------------------RVKSSSPQ---RKPGKVFVYHF-------TQ-SSSANPW---------PKWT--------G-AMHG---------YEI-EYVFG------IPL------SYSKNYKRR------------------------ 615
616 NANTQISEDC--------------------LYLNIWA----------P-----------ADAYN---------LTVMVW----F-------F---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FYS-GS------PS------L--SIYDGRALAA-----TQ----HVIVVN------I-N---YR-LG-------------PFGFLYL--------DHPDAP---------G---NMGLLD--QQLA----------------------------------------------L-----------------------------H--WIRQN-----------------------------IVSFG---------------------GN------------------------------------------------------PDK----V-SV--F-G--QS-----------------AG-----------------------------A-ASIVA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LIAPG-------S---------------R---------------GLFKNAILQ-----------------------------------------------------------------------------------------S-GSLE---------NTWAINS------PFRA---------------------------KQKSE---------KLL----ELVGC----------------------------------------------------------NKT----------------------------------------------TVENSMSCLRL--V-------------------------------------------------------SPEQLS--L-STW-NISLTYLEFPFVI----------------------------------------------V------SR----DK--------------H--FF----GHLDARAA------------------------------------------LREGD------F-NR---------------------------------------------------------------------------------------------------------------------------DVN-LM------------------I-------------------GMNKDEGNYW-------NI-------YQL---PQF---------FDKAE-PPELT---------RHQF----------------------DNLIDSTFSI-----QPDIIRS-----------------------------------AAKYIY-----------------------------------------------------SDPNCTDHGRKT-------RFYAG---QMNQI-----VG-D------------------------------YFFSCD----SLWLADQFFLFL------------------------QI-CSTPNGSLKNPPKVFVYYF-------TQ-SSSANPW---------PKWT--------G-AMHG---------YEI-EYVFG------VPL------SYSKIYKRR------------------------ 616
617 NAQNPLSEDC--------------------LYLNLWL-----P--HDT-----------A-N-A---TTK--K-PVMVW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FFS-GS------NE------L--WVYDGKTLAA-----HG----DVIVAS------F-N---YR-VG-------------SFGYLST--------GDGR---I-----K-G---NFGMKD--QVMS----------------------------------------------L-----------------------------K--WIHDN-----------------------------IEAFG---------------------GD------------------------------------------------------PAS----V-TI--F-G--ES-----------------SG-----------------------------A-SSAGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-MMSSH-------S---------------E---------------HLFHRAIFQ-----------------------------------------------------------------------------------------S-GSAD---------SQWSFMS---AEQ---A---------------------------EERSQ---------KFF----KAINC----------------------------------------------------------TM----HDAD---------------------------------------KLLK---CLR---D------L------------------------------------------------DPYVILNN----E-WVDLR------------------F-MVFPWA----------------------------P------TV----DH--------------D--FL----TDTPY-NL------------------------------------------LKAGK------F-QH---------------------------------------------------------------------------------------------------------------------------KD--SL------------------L-------------------GVNKDEGTF------------------WI-------LFALPS-LSKD--HESLLN---------RTSF----------------------LRAI-DTLL-------WDL----------------------PETTK-D---------EVKGHY-----APKDP---------------------------------------N---DQ-AAHR----------------D---ALDKV-----CG-D------------------------------RSFTCP----TKKLMEVY-TEA-----GI------------------------------K--THFYYL-------TH-RATNEAW-------P--PWM--------G-VIHG---------AEI-QWVFG------MALN--ES-KNYTPE--------------------------- 617
618 NAKNPLSEDC--------------------LYLNVWV-----P--DSP-----------P-K-D---RKP--R-PIMVW----V-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FYS-GS------NE------L--WVYDGKALAD-----HG----DVIVAA------M-N---YR-VG-------------SFGFLST--------GDGR---I-----R-G---NFGLKD--QQTA----------------------------------------------L-----------------------------R--WIKNN-----------------------------AAGFG---------------------GD------------------------------------------------------PDQ----I-TL--F-G--ES-----------------AG-----------------------------S-ASVGY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSES-------S---------------A---------------DLFQRAIMQ-----------------------------------------------------------------------------------------S-ASPD---------SFWSFMT---AEK---A---------------------------ESRSA---------KLF----ANIGC----------------------------------------------------------A------NDE---------------------------------------NILD---CLQ---S------K------------------------------------------------PAQEIFDN----E-WVVEN------------------F-LNIPWV----------------------------P------SV----DG--------------D--FL----VAPPE-SL------------------------------------------LEQGR------F-QH---------------------------------------------------------------------------------------------------------------------------KD--LL------------------V-------------------GANKDEGTY------------------FI-------LYDVPG-LSKD--GPSPLN---------DELY----------------------KNGV-DVVA-------WDL----------------------PAAGR-A---------EVATFY-----KPPGA---------------------------------------S---NG-DANT----------------A---ALGEI-----AG-D------------------------------RSFTCP----VLDF-AAQ-SAP-----GA------------------------------R--TFVYHF-------TY-RASNEVW-------P--EWM--------G-VIHA---------AEI-QWIFG------MSLN--TT-RGY------------------------------ 618
619 --PKQTAEDC--------------------LYLYIWT----------P-----------------LSANATTSFPVMVY----I-------H---------------------------------------------------------G--------------------G----N-----------------------------------------------------------------------------FVH-MS------AD------S--ELFDAEELAY-----KG----QVIVVT------L-D---YR-LG-------------ALGFLL----------TQD-RRA-----T-S---NYGILD--QRQA----------------------------------------------L-----------------------------K--WVREN-----------------------------IKAFG---------------------GN------------------------------------------------------PDM----V-TL--F-G--QS-----------------AG-----------------------------A-QSTVV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LMTKE-------S---------------G---------------QYFQRAIIE-----------------------------------------------------------------------------------------S-APL--------------------------S---------------------------IPFKTEEEMIFISNMLF----DQLNC-----------------------------------------------------------SPKD-------------------------------------------------LDCLNK--F-------------------------------------------------------SADDIAEAQLKIR-Q-YPSSIKLLEFFEPWV------------------------------------------P------YV----DG--------------V--VV----PSQPL-DA------------------------------------------FRKGI------V-MN---------------------------------------------------------------------------------------------------------------------------KP--LL------------------M-------------------GSLTEETRV------------------------------------------------------------------------------------------------------------------------------------------FIYEAY-NQSLSALEYSLALTL-TFPKKPLDVL-------------QMYPP-TVA-----PDQ--R----------------D---GLQIP-----AT-D------------------------------FIFTCS----TRNFTRNVLKQ-------N------------------------------GGRVWTYVY-------DH-AFSF-PGWGRF--SFCEGHV-----------CHG---------SEI-PFVFQSAKIGNFTMTPDE----------------------------------- 619
620 CLP-QMSEDC--------------------LYLNVYM----------P-----------------LNTSPRSGKAVMIF----L-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FES-YT------AG------A--DIYNSEIFAS-----KG----DVIVVT------V-N---YR-LG-------------ALGFLVT--------GTGS-NSA-----T-G---NYGIKD--QRLA----------------------------------------------L-----------------------------E--WVNKN-----------------------------IEKFG---------------------GN------------------------------------------------------PKN----V-TL--F-G--QS-----------------AG-----------------------------A-LSALI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LSSRK-------A---------------D---------------NLYQRAIIQ-----------------------------------------------------------------------------------------S-GPF--------------------------S---------------------------IPFKSFRQAYSQGVEFS----RNLHC-----------------------------------------------------------PPGD-------------------------------------------------IVCMRS--R-------------------------------------------------------SPREILDAQASTR-S-FGN---VLQQFMPWS------------------------------------------P------YH----DG--------------D--EV----PVSPL-KA------------------------------------------IGKGL------I-AN---------------------------------------------------------------------------------------------------------------------------KS--LI------------------I-------------------GTTADEGLT------------------------------------------------------------------------------------------------------------------------------------------YVYNMF-PTPLNMMTYSGLLLM-INQNEAFTWL-------------SRYSP-KNP-----RDS--R----------------A---ALSSL-----AT-D------------------------------YLFTCP----TRQIASDLALS-------N-------------------------------HNLWLYVF-------DQ-GMSFLNGTGIL--NNCQNNA-----------CHG---------ADI-PYLFQNVR-KVFPLKPEE----------------------------------- 620
621 -------EDC--------------------LHLAVYL----------PSRLTKVTNTTDGEYFEMIDNIEIANLSVMVF----F-------Y---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FTA-GA------NG------V--LLYDARFIAE-----KG----DVVVVV------P-N---YR-VG-------------PFGFFYQ--------DTGDTDAV-----L-G---NFGIWD--QIKA----------------------------------------------L-----------------------------E--WVQEN-----------------------------IQSFG---------------------GN------------------------------------------------------KKS----V-TL--F-G--QS-----------------AG-----------------------------A-QSIAV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-MVNNY-------S---------------E---------------PLFHGAILE-----------------------------------------------------------------------------------------S-NPF--------------------------G---------------------------ITYKNKTEAQDIADKFA----KHMGC----------------------------------------------------------RDEATTA--------------------------------------------VDALACMKS--K-------------------------------------------------------TMEETLAALRNFSIVNQINPNSLTQVFEPWA------------------------------------------P------VL----DE--------------D--LL----NEHPY-YT------------------------------------------FLKGN------N-HD---------------------------------------------------------------------------------------------------------------------------KP--MI------------------M-------------------GFAKDEGMF------------------------------------------------------------------------------------------------------------------------------------------FILQIF-PEKSETLKTYDLLMKLMFGDNYTDVE-------------EHYPPECGKLRNSECDN--R----------------N---PMDDL-----VT-D------------------------------YLFTCP----SRRVMNADA---------S------------------------------SNNVWWYMF-------NQ-TWSFPEFWENY--TKCYDLV-----------CHS---------AEL-PYLFD------------------------------------------------ 621
622 -------EDC--------------------LHLAVYL----------P------------------NNIEIANLSVMVF----F-------Y---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FTA-GA------NG------V--LLYDARFIAE-----KG----DVVVVV------P-N---YR-VG-------------PFGFFYQ--------DTGDTDAV-----L-G---NFGIWD--QIKA----------------------------------------------L-----------------------------E--WVQEN-----------------------------IQSFG---------------------GN------------------------------------------------------KKS----V-TL--F-G--QS-----------------AG-----------------------------A-QSIAV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-MVNNY-------S---------------E---------------PLFHGAILE-----------------------------------------------------------------------------------------S-NPF--------------------------G---------------------------ITYKNKTEAQDIADKFA----KHMGC----------------------------------------------------------RCQMS--------------------------------------------------SCMKS--K-------------------------------------------------------TMEETLAALRNFSIVNQINPNSLTQVFEPWA------------------------------------------P------VL----DE--------------D--LL----NEHPY-YT------------------------------------------FLKGN------N-HD---------------------------------------------------------------------------------------------------------------------------KP--MI------------------M-------------------GFAKDEGMF------------------------------------------------------------------------------------------------------------------------------------------FILQIF-PEKSETLKTYDLLMKLMFGDNYTDVE-------------EHYPPEVSA-------S--K----------------N---PMDDL-----VT-D------------------------------YLFTCP----SRRVMNADA---------S------------------------------SNNVWWYMF-------NQ-TWSFPEFWENY--TKCYDLV-----------CHS---------AEL-PYLFD------------------------------------------------ 622
623 ---ETLSEDC--------------------LYLNIWT----------P-----------E-SAH---NAA-----VMLW----F-------H---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------FFW-GA------GS------I--SLYNGGTLAA-----VE----KVVVVT------V-N---YR-LG-------------AFGFLTL-------KHTDI---------R-G---NMGMMD--QVLA----------------------------------------------I-----------------------------E--WVKEN-----------------------------IRYFG---------------------GD------------------------------------------------------PDK----I-TL--V-G--QS-----------------AG-----------------------------G-ASVTY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSHV-------G---------------R---------------NNFRRAIVQ-----------------------------------------------------------------------------------------S-GTSN---------SPALDPK---TMDE--T---------------------------NHYAQ---------LLS----ADLGC----------------------------------------------------------VESIIPLNITTSLHDLPTPADPIDYSIYEENYESSSEVTLGEIDQYFENHATEVIACLR---T------R------------------------------------------------EPIDFVT----SL-WSFGLHF----------------------------------------------------P------TI----DD--------------A--FI----RETPA-DS------------------------------------------INGED------F-KR---------------------------------------------------------------------------------------------------------------------------TE--LL------------------I-------------------GMNENEAAVN-------LL-------RMN------WLPRENDSVIDASLFHQRIQDFYRRDQNDNI---------------------------LAETTAFM---------------------------------------------------Y----RDWYDK-------------------------------------------HNPEKLR----------------D---AYEDI-----VG-D------------------------------HDIKCP----SIEFARTYSASD-------------------------------------STQVYMYQY-------TH-RPSLSSW---------PEWM--------G-CVHG---------DEL-AFVFG------HPLHME-NGYTEEE---------------------------- 623
624 TTTDECSEDC--------------------LFLNVWT----------P-----------Y-PAP---SDA----PVVVF----I-------H---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------LIA-GT------TS------A--SLYNGATLAA-----VE----NVVVVS------M-N---YR-LG-------------LLGFLSF-------FTENE---------P-G---NLGLLD--QAMA----------------------------------------------L-----------------------------L--WVKDN-----------------------------IEHFG---------------------GN------------------------------------------------------ADS----V-TL--I-G--HS-----------------AG-----------------------------A-ASVGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LMSPA-------S---------------R---------------PFFRRAILQ-----------------------------------------------------------------------------------------S-GAPN---------TGWTMTS---RAQD------------------------------LWVAG---------KLA----KNVHC-------------------------------------------------------------------------------PTWLDSSNLSYESVVID---------------TLRCLR---E------R------------------------------------------------GPQNLVNSDPLDA-SKTVGGY----------------------------------------------------V------VV----DG--------------F--FL----PDNPQ-LI------------------------------------------LADSD------M-KQ---------------------------------------------------------------------------------------------------------------------------TS--II------------------I-------------------GTVDEESLLN-------MG-------HLP------KFRFDIPKV-------EAVRNTYSADD-------------------------------YKQSIDLLFPYVDQSVRD------------------------------------VIWFEY----RDWFDP-------------------------------------------NNGTKLH----------------R---SVIDM-----WE-D------------------------------FCMVCP----IKEFANFY-AEA-------------------------------------GNNVYAYNY-------DH-RSSKSPW---------KEWL--------G-TVHA---------DEL-LFTLG------LAM--------------------------------------- 624
625 -----------------------------------------------------------------------------------V-------L---------------------------------------------------------G--------------------S----G-----------------------------------------------------------------------------H----S--------------S--YEAGPQYLLD----------QDVVFVA------F-N---YR-LG-------------ALGFLSTNSSETK-----------------G---NFGFLD--QVMA----------------------------------------------L-----------------------------E--WVRDH-----------------------------ISHFG---------------------GD------------------------------------------------------PEL----V-TI--I-G--IS-----------------AG-----------------------------S-MAVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LASPL-------S---------------A---------------GLFHRAILM-----------------------------------------------------------------------------------------S-GS-----------ATNHFDIDNLFWTR--------------------------------------------KLA----RELGC-------------------------------------------------------------------------------------------------------PMYDPTD-VVECLRNE---------------------------------------------------------TWTRIVEVCKAWE------------------------------------------------------------TYQLVNMKWNYEIDGH----------------FL----HNHPT-EL------------------------------------------IKEGNFNKVPLL------------------------------------------------------------------------------------------------------------------------------------------------------I-------------------SFT-------------------AN-------------------------------------------------------------------------------------------------------------------------------EF-DYNANVHLENQHLLHDFASNFVDYAPELFLYRHDAQIGEKLKDFYLGDNTTEINSENIE--------------------NFGQI-----FS-D------------------------------AYIGHGVHRLVQLASHF-------------------------------------------TPVY---------YTRMDYVGDQSLSAPLNGENKPV----------G-VGHA---------DDLHYVLPGYWYGPLMAAND------------------------------------- 625
626 -ATESLNEDC--------------------LFLNIWS----------P-----------Y-PRR---SDA----AIMVW----F-------H---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------FNW-GS------SG------V--KEYNGQVLAV-----TQ----NVIVIT------V-N---YR-LG-------------PLGFLSL-------GNSEV---------P-G---NVGLMD--QAMA----------------------------------------------L-----------------------------R--WVKEN-----------------------------IANFG---------------------GD------------------------------------------------------PEL----V-TI--F-G--SS-----------------AG-----------------------------G-ASVGY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LFSPI-------S---------------R---------------VLFRRAILE-----------------------------------------------------------------------------------------S-GTPN---------SPALRPI---DDET--N---------------------------TVNTK---------KLI----ESLGC----------------------------------------------------------MYDERDL-----------------------------------------AHPDT-IECLR---N------K------------------------------------------------PAEDVTS----NV-FAGKNHN----------------------------------------------------I------VI----DG--------------E--FL----DRDFD-TM------------------------------------------MAEHD------F-KS---------------------------------------------------------------------------------------------------------------------------TE--IM------------------V-------------------GNCEREWMIN-------LY--------L--------------------------NNFYSLESQNPLTH------ALYRKYAHPCIKGANLSSAVTESVYFH---------------------------------------------------Y----TDWTDP-------------------------------------------YNPIKLR----------------D---AVDAI-----CG-D------------------------------YKLSCP----SVQFVHTY-AMA-------------------------------------GNPAYYYSL-------HK-RANASPW---------PEWM--------G-AVHG---------QEI-TYVFG------HPLDVTNEGFLKED---------------------------- 626
627 SVGENLSEDC--------------------LFLNIWA----------P-----------S-PFT---NNT----AVMVW----I-------H---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------FNW-GS------AS------V--KQYDGKMLSA-----SQ----GVVVVT------I-N---YR-LG-------------PLGFLAL-------KDSEI---------R-G---NFGLMD--QAMA----------------------------------------------L-----------------------------Q--WIQEN-----------------------------IADFG---------------------GD------------------------------------------------------PEL----V-TI--F-G--SS-----------------AG-----------------------------G-ASVGY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSNM-------T---------------R---------------NLFRRAIVE-----------------------------------------------------------------------------------------S-GSPT---------TPPLKPR---DSESILA---------------------------QVSAD---------SLV----RGVGC----------------------------------------------------------S-GLRDI-----------------------------------------DNSSKLMECLR---E------I------------------------------------------------PAYNISH----DQ-FASLNIF----------------------------------------------------V------VI----DG--------------T--LL----TNSPE-VQ------------------------------------------LETGD------F-KN---------------------------------------------------------------------------------------------------------------------------TE--IL------------------A-------------------GQCQNEGMID-------MV-------RL--------------------------VPGYSIDTESLLTYDEFEMGVRYITWA-----TSSQTKGLAEMAIFQ---------------------------------------------------Y----TDWKDK-------------------------------------------TNPAKLR----------------D---AVNDV-----YG-D------------------------------YILKCP----TIDIVNAY-SKA-------------------------------------GLDTYYYDL-------RR-RSSGSPW---------PGWM--------G-VVHG---------DEI-QYIFG------HPLNTEFGPYSDED---------------------------- 627
628 NTESGTDEDC--------------------LFLDVFV--------PLP-----------Q-R-----DKP--F-AVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FMY-GA------GT------V--SMLSPLPLVS-----LG----DVIVVT------I-N---YR-LG-------------ALGYLTT--------GDEI---T-----P-P---NLGILD--QITA----------------------------------------------L-----------------------------K--WIRKY-----------------------------ISAFG---------------------GD------------------------------------------------------PDR----V-TL--F-G--DS-----------------AG-----------------------------S-ASIHI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LMSPM-------S---------------F---------------SLFHRAIMQ-----------------------------------------------------------------------------------------S-GAAT---------SSWARSP--DLAT---A---------------------------RDRAL---------TLG----RLVGC----------------------------------------------------------DE---VSSSA---------------------------------------QLLQ---CLG---Q------V------------------------------------------------SADEIVAQ---QQ-QVLAETGD------------PADI----AFL----------------------------P------IV----DH--------------V--VI----PDTP-DIV------------------------------------------GEMGS------Y-NN---------------------------------------------------------------------------------------------------------------------------VS--VI------------------I-------------------GANADEGMM------------------SM-------MHLFP---QAT--TTPFVT---------RQQL----------------------RRFL------------STA--LNV-----------------HDPVLQE---------LIELVY---DVD-EHGDLSSHTNRVYSDRTQKD-------------VCKTGYVNDD---GN-LDFF----------------D---KLNDI-----VG-D------------------------------MTMFCP----TAAVAS----EA-----GL------------------------------E--VYRYHM-------TH-RPSESFW------RP-LTWT--------R-VNHG---------ENL-LFVFG------VHFL--PH-LNWTL---------------------------- 628
629 ---EPTDEDC--------------------LHLNIYA--------PKS-----------A-N-------K--A-AVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FVL-GS------GS------N--VYYDGFPLAA-----IN----DVIVVG------I-N---YR-LG-------------VLGFLST--------GDDV---I-----S-G---NYGLMD--QLEA----------------------------------------------L-----------------------------K--WIKAN-----------------------------IEYFG---------------------GD------------------------------------------------------PDR----I-TI--F-G--ES-----------------AG-----------------------------S-ISVNL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-IFSPM-------S---------------K---------------GLFKRAIMQ-----------------------------------------------------------------------------------------S-GVSA---------AAFTYNN--DKEM---I---------------------------TKLAH---------GVG----ELVGC----------------------------------------------------------KS----DTSD---------------------------------------ALLQ---CLR---D------VT-----------------------------------------------PADRFLDVQDLTT-GRLEKVTG------------LKGL--YFPFL----------------------------P------CI----DG--------------H--FV----TDDPVEMI------------------------------------------NDERI------I--A---------------------------------------------------------------------------------------------------------------------------ID--AM------------------M-------------------GSMANENIV------------------SL-------LAVYPE-ASNW--SSVTMN---------RHEF----------------------EKHL------------PTFSPVSLL--------------AKGPLVV-E---------AVKLLY----TDWYTI--------------------------------------DT---PK-ENYT----------------S---AFVSI-----FS-D------------------------------EAIVCP----TNTLAHAM-SKS-----GS------------------------------N--VYLYQM-------SY-SASRSMW-------G-FDWT--------K-AAHG---------DDL-QFVFG------WHFR--SQ-NDWQMSPED------------------------ 629
630 ------SEDC--------------------LYLDVLV--------PEP-----------K-PKA---A------AVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------YHF-GT------KN------F--QKSNAMALVA-----VE----DVIVVS------I-N---YR-LG-------------ILGFLST--------EDGA---I-----P-G---NLGLLD--QRLG----------------------------------------------L-----------------------------L--WVKEN-----------------------------IAAFG---------------------GD------------------------------------------------------PDR----V-TI--F-G--ES-----------------AG-----------------------------S-GSVNS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPM-------S---------------A---------------GLFSGAIMQ-----------------------------------------------------------------------------------------S-GAMS---------PTWTFKT---RQKN--A----------------------------ELTF---------ALG----EAMGC----------------------------------------------------------ETK----------------------------------------------SSTELLTCLR---G------K------------------------------------------------TKEDIDAIHETGT-TSVL---Y---------------------LVA---------------------------P------VA----DG--------------H--FL----PLDPM-QA------------------------------------------QEEGS------F-NP---------------------------------------------------------------------------------------------------------------------------SN--VM------------------I-------------------GSLGHEG---------------------N-------IFAIPLMVGMEGYEKLSVN---------RTTF----------------------DTFT-SMFTQMTDPLALDLIKLTYL--------------SPEQLT-----------------------SGDPE----------------------------------------------ENLV----------------D---PMAQF-----LG-D------------------------------RILLCP----TFSTAQQL-AAT-----G-------------------------------V-QVYTYLM-------TH-SPAYSLW-----GSK-YTWL--------G-DTHG---------EDI-PYVFG------SAFL--AQ---DGEDEEWFMRGRLADDE-------------- 630
631 ------SEDC--------------------LFLDVAV--------PQP-----------Q-PEN---A------AVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------YHV-GA------PK------G--HANDTLFFAA-----MG----DVIVVT------I-N---YR-LG-------------MLGFMTT--------GDDS---M-----P-A---NLGLLD--QRQA----------------------------------------------L-----------------------------L--WVQEN-----------------------------IASFG---------------------GD------------------------------------------------------PSR----V-TI--F-G--VS-----------------AG-----------------------------S-GSVNL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPM-------S---------------A---------------GLFSGAIMQ-----------------------------------------------------------------------------------------S-GALT----------SWTHQP---VQTN--I----------------------------DMTK---------AFG----KELGC----------------------------------------------------------DGA----------------------------------------------TSVELVSCLR---G------K------------------------------------------------PVEELIELQQNAT-TNL--ARY---------------------TVF---------------------------P------VP----DG--------------E--FL----LKDPF-LL------------------------------------------AAEGS------I-NP---------------------------------------------------------------------------------------------------------------------------AN--VM------------------V-------------------GCLSEEG---------------------N-------MAVVP-MFGRD-----RVN---------KEAY----------------------GVYM-ANILQMRDPLIQDLATVVFG--------------SDEMFS-----------------------SLEP------------------------------------------------DYR----------------D---AAANF-----LG-D------------------------------SVFLCP----TFDFTQLL-AQA-----G-------------------------------K-TVFSYLM-------TH-RPSHSVW-----GKN-MTGL--------G-PTHG---------EDV-AYVFG------APFM--YDNDADDEDQDCYLVGRFNVEE-------------- 631
632 ------SEDC--------------------LTLDVFV--------PEP-----------K-PKD---A------AVMMW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------YHL-GA------GS------I--PELLPAPLAA-----YN----DVIVVT------I-N---YR-LG-------------PLGFLAS--------GDGS---I-----P-A---NIGMLD--QRQA----------------------------------------------L-----------------------------I--WIQDN-----------------------------IEAFG---------------------GD------------------------------------------------------PNR----V-TI--F-G--ES-----------------AG-----------------------------S-ASVNL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSTM-------S---------------A---------------GLFSRAIMQ-----------------------------------------------------------------------------------------S-GALT---------DTWTHHA---TMFE--V---------------------------VKMTY---------DMG----KTLGC----------------------------------------------------------DVT----------------------------------------------TSSALVRCLR---A------K------------------------------------------------PVEDFITIYEGES-PGVLSAPF---------------------YFH---------------------------P------VA----DG--------------Q--FL----SDDPI-KM------------------------------------------ASEGS------F-NQ---------------------------------------------------------------------------------------------------------------------------VN--VM------------------V-------------------GCTKDEG---------------------S-------VFTLPMITGGGLIEPPSMN---------LSTF----------------------RQMI-AMNLRTQDPLTLDLAQNMFA--------------TPEQLA-------------------------DPD----------------------------------------------ADYL----------------S---SVNKL-----IG-D------------------------------KMMLCP----TFGMSEDL-SRA-----G-------------------------------R-NVYSYVM-------TH-NPAISVW-----GSQ-YDWL--------G-ASHT---------EDI-PYVFG------APFL--R----------------------------------- 632
633 ------SEDC--------------------LTLDVFV--------PEP-----------K-PLS---A------AVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------YVV-GA------GS------I--PEALPVPLAV-----MN----DVIVVT------I-N---YR-LN-------------ILGFIVL--------GEED---V-----SEA---NVGMLD--QRQA----------------------------------------------L-----------------------------V--WVQEN-----------------------------IAAFG---------------------GD------------------------------------------------------PSR----V-TI--F-G--ES-----------------AG-----------------------------G-MSVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VLSPM-------S---------------K---------------GLFSGAILQ-----------------------------------------------------------------------------------------S-GAVT---------SQWSYGT---LAEG--E----------------------------ETAF---------VYG----RALNC----------------------------------------------------------SQD----------------------------------------------THRELAECLR---G------I------------------------------------------------PADDIVSYLASNP-PEAYT--H---------------------AIR---------------------------P------FV----DG--------------E--FI----PRDPK-EM------------------------------------------YAAGE------V-NE---------------------------------------------------------------------------------------------------------------------------VS--IM------------------I-------------------GCLSEEG---------------------T-------MIIIPPDASLESSDRPVLD---------KTNY----------------------DGLL-PVFIRNVDELVKDTAALVYM--------------SPEEMM-----------------------KAEP------------------------------------------------EYT----------------D---VIVDC-----MG-D------------------------------FFFLCP----SFEAADHL-SAA-----G-------------------------------L-PTYKYIM-------SH-RPSISIW-----GKG-MTWL--------G-ATHG---------EDI-PYTLG------APFM--LD--ILDPDQSFLLTGLFNEQE-------------- 633
634 TVEMEETEDC--------------------LYLDVFV--------PSP-----------R-PNP---A------PVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FFA-GA------GS------V--PEQLPIPLSF-----YG----EVIVVT------F-N---YR-LG-------------MLGFLNT--------GDGE---I-----P-A---NLGMFD--QREA----------------------------------------------L-----------------------------K--WVQEN-----------------------------IAAFG---------------------GD------------------------------------------------------PGR----V-TI--F-G--ES-----------------AG-----------------------------G-ASVNF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPL-------S---------------A---------------GLFRGAILQ-----------------------------------------------------------------------------------------S-GNAL---------LNMGNTD---------L---------------------------VEKTF---------EFG----KGAGC----------------------------------------------------------DFN----------------------------------------------NSKDLAECLR---G------R------------------------------------------------SLEDLKDG------------------------YIIINVHPGHIELA---------------------------P------VV----DG--------------H--FL----NDTPL-KL------------------------------------------MQQGH------V-NV---------------------------------------------------------------------------------------------------------------------------DN--VL------------------H-------------------GDLLNEGSC---------------------------FTIFTGFASTEDIPPPVLT---------LDDF----------------------KNHLANFFMID------------------------------DPLIL-D---------TIVFVL----SDSAHI---------------------------------------T---GNKTDYF----------------K---ELADA-----F--D------------------------------SIISCP----INPFSNLL-STA-----G--------------------------------KTAYRYTM-------TH-APSHSAL------GP-LKWA--------G-ATHV---------EDI-PYVFG------SPLL--REREDGPKGMSGFFDGAEE----------------- 634
635 -------ENC--------------------LYLNIFV--------PQS-----------S-EAV---ASK--K-AVVIW----M-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FYI-SS------GS------A--PEHDGTVMSA-----LG----NIIVVT------I-N---YR-LG-------------PLGFLST--------GDEV---A-----T-G---NYGLLD--QRQA----------------------------------------------I-----------------------------I--WVREN-----------------------------IEAFG---------------------GD------------------------------------------------------IDR----I-TV--M-G--ES-----------------AG-----------------------------A-ASIGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSHG-------S---------------R---------------GLFKRAIMQ-----------------------------------------------------------------------------------------S-GSGH---------SPWAIVP--SSEV---A---------------------------RKRSF---------ALG----ELVGC----------------------------------------------------------SH----TTTS---------------------------------------QLIQ---CLR---Q------V------------------------------------------------PADSLVQA----Q-LLVTNKTG------------EAKN--AIAFT----------------------------P------IV----DG--------------V--FL----ADTPTNLF------------------------------------------EQKNP------V-NQ---------------------------------------------------------------------------------------------------------------------------AD--IL------------------I-------------------GSNADEGTM------------------SL-------LFMFPH-LSNI--TNPVIN---------HTIF----------------------DHVT------------PQI--IYNN--------------H-NSLIL-E---------SIKFMY----TDWNTA--------------------------------------DS---EH-TNYF----------------Q---SLSQM-----SG-D------------------------------ESFTCP----ADLFAKQY-FER-----GN------------------------------T--VYMYHF-------SH-HPSTSIY-------N-TSWL--------G-ASHA---------EEI-PFVFG------WHFH--R----------------------------------- 635
636 -----------------------------------------------------------------------------------I-------P---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FVQ-GT------GS------C--LLYDASKF-------AN---SSIIVVN------I-N---YR-LG-------------ALGFLGT------------DLLS-------G---NFGFLD--QVMA----------------------------------------------L-----------------------------Q--WVRSN-----------------------------IEAFG---------------------GD------------------------------------------------------KNK----V-TI--F-G--ES-----------------AG-----------------------------A-LSVIS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LVSER-------S---------------K---------------NLFQRAIVS-----------------------------------------------------------------------------------------S-ATFT-------L-------GL---KTKSQI---------------------------RGISN---------GFT----SKIGC----------------------------------------------------------N----I----------------------------------------------EDIDCLRS--K-------------------------------------------------------SPEEILKAQDQVANVFRGKLLDIVTVWT---------------------------------------------P------VV----DC--------------D--II----LGQPLTMI------------------------------------------------RDGILV-NN---------------------------------------------------------------------------------------------------------------------------VP--LI------------------I-------------------GETKDEGNLFVYFNFQKK---------------------------------------------------------------------------------------------------------------------------------ITQHKY-RNMISLMFG-SNS--------------------------QMVLNKYPAPTSDDG----------------DNKGD-CRPILSKL-----YG-D------------------------------YVFRCPNRYLINRLLTQNNKSSSSSSPV----------------------------------IYHYQF----------RHSLSSGNPIPYCSG-------------I-VCHG---------SEL-PLIFNTYESAMNFELD------------------------------------- 636
637 CSEVGTSEDC--------------------LYLDVFI----------P---------------RTVNPGSK--VPVMVF----I-------P---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FTQ-GT------GS------C--PLYDGLKF-------AN---SSVIVVN------V-N---YR-LG-------------VLGFLCT------------GLLS-------G---NFGFLD--QVMA----------------------------------------------L-----------------------------D--WVQEN-----------------------------IEVFG---------------------GD------------------------------------------------------KNQ----V-TI--Y-G--ES-----------------AG-----------------------------A-FSVAA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LSSEK-------S---------------E---------------GKFHRAILS-----------------------------------------------------------------------------------------S-TPYT-------V-------GL---KSQTVA---------------------------RGFAG---------RFS----SKIGC----------------------------------------------------------D----L----------------------------------------------EDIDCHRS--K-------------------------------------------------------SPEEILAIQKELGLAIGDKILDAFTIWS---------------------------------------------P------VV----DG--------------I--NV----NEQPLTMI------------------------------------------------KQGT-T-HD---------------------------------------------------------------------------------------------------------------------------VP--TI------------------I-------------------GDNQDEAILFVYMTYKNV---------------------------------------------------------------------------------------------------------------------------------VIPSSY-RTMVHVLFGIANG--------------------------NKVLEHYPLP----G----------------FLK-D-SRPILSKL-----LT-D------------------------------YLFRCPGRYHV-------SKSAQANESP----------------------------------IYHYQY----------KQVLSGGHSFEACEG-------------L-VCHG---------TEL-PMVFNTYESALDLDLEE------------------------------------ 637
638 -SPIGTSEDC--------------------LYLDVFT----------P---------------KDATPNSK--YPVIVY----I-------P---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FSV-GS------GS------V--PLYDATKF-------AQ---SSVIVVN------I-N---YR-LG-------------VLGFMGT------------DLMH-------G---NYGFLD--QIKA----------------------------------------------L-----------------------------E--WVYNN-----------------------------IGSFG---------------------GN------------------------------------------------------KEM----I-TI--W-G--ES-----------------AG-----------------------------A-FSVSA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LTFTY-------S---------------R---------------QYFNAAISS-----------------------------------------------------------------------------------------S-SPLT-------V-------GL---KDKTTA---------------------------RGNAN---------RFA----TNVGC----------------------------------------------------------N----I----------------------------------------------EDLTCLRG--K-------------------------------------------------------SMDEILDAQEKVGLTFGDKILDAFTIWS---------------------------------------------P------VI----DG--------------D--II----PMQPLTAV------------------------------------------------KEGK-T-YD---------------------------------------------------------------------------------------------------------------------------VP--TI------------------I-------------------GNVKHEAIPFIYSFFQDS---------------------------------------------------------------------------------------------------------------------------------VGIDYY-RVLVAIVFP-LNA--------------------------MKILPLYPAAPRGQ---------------------D-SRPILSEL-----IT-D------------------------------YLFRCPDRYHT-------VTNAKKLSSP----------------------------------TYHYHY----------VHVKSTGHSLDACDD-------------K-VCHG---------TEL-SLFFNSYE-LMGERLDNDE---------------------------------- 638
639 FDVTGISEDC--------------------LTLDVYT----------P--------------------SLSGQRPVMVF----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FIS-GW------SS----------MADMRVYAA-----KY----NVVGVA------I-Q---YR-LG-------------ALGFMST--------EDNT---------VKG---NMGFKD--QILS----------------------------------------------L-----------------------------K--WVQEN-----------------------------IANFG---------------------GD------------------------------------------------------PNQ----V-TI--F-G--ES-----------------AG-----------------------------A-WSVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-FVSHM-------S---------------N---------------GLFNRAILM-----------------------------------------------------------------------------------------S-GSAVGMPQLSPSAQPLQEAI---------------------------------------------------KLA----NAIGC----------------------------------------------------------PNA----------------------------------------------TTEELTNCLLR--K-------------------------------------------------------PAMEIVNA------TTMSMEFN---------------------------------------------------P------VV----DN--------------E--YF----TDVPL-AL------------------------------------------MEKGL------F-QK--------------------------------------------------------------------------------------------------------------------------GVD--LL------------------A-------------------GFTFVEGFMLGQMFFSHVDITNLNYSSFRECVSIAYAAFMPGMTINPALIDEALKVYIKDSESPEQMT------------------------------------------------------------------------------------Y--------------------------------------------------------------------------------ALTKL-----VG-D------------------------------CIITQATYNTALKAMEFG-----------------------------------------HQKVYLYDF--------HGRPFYSNK---------PEGI--------L-ADHG---------DDI-IFAFGFSEATKSYGLEYPED--------------------------------- 639
640 PIDKIQDEDC--------------------LHINVYV--------PQP-----------R-K------AN--T-PVMFW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FNV-GS------GT------R---MYDSTILSS-----LN----DVIVVT------I-N---YR-VG-------------PLGFLST--------GDDV---A-----S-G---NYGFLD--QVEA----------------------------------------------L-----------------------------R--WVQQN-----------------------------IAAFG---------------------GD------------------------------------------------------PDT----V-TI--F-G--ES-----------------AG-----------------------------A-A------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LQ-----------------------------------------------------------------------------------------Q--------------CPGLFLS--DASK---T---------------------------NKIAH---------GQG----KLVGC----------------------------------------------------------EK----DNSK---------------------------------------ELIE---CLR---T------V------------------------------------------------PADKFRDVSDVTK-V-------------------VFDIGTLVPFT----------------------------P------TI----DG--------------H--FI----HEDPMELI-------------------------------------------AKKA------F-NS---------------------------------------------------------------------------------------------------------------------------EE--LM------------------I------------------------------------------------------------------------------------------------------------------------------------G---------------K-KQAVL-D---------TIKLIY----VDWDHA--------------------------------------DE---EN-ANYL----------------S---ALSQM-----AG-D------------------------------MIMVCP----TDIAARAH-YAA-----GL------------------------------A--TYLYQM-------TH-VPAKSLW-------P-INSN--------T-AKHG---------DDI-SFTFG------YTLL--SE-KQLALGGDETTIYKQTP---------------- 640
641 PTDKIQDEDC--------------------LHLNVYA--------PQP-----------R-K------DN--T-PVMFW----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FIM-GS------GT------R---MYDATILSS-----LN----DVIVVT------I-N---YR-LG-------------ALGFLST--------GDDV---A-----P-G---NYGFLD--QVEA----------------------------------------------L-----------------------------R--WVQQN-----------------------------IAAFG---------------------GD------------------------------------------------------PNT----V-TL--F-G--ES-----------------AG-----------------------------A-MSAHY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VMSPM-------S---------------K---------------GLFKRSILQ-----------------------------------------------------------------------------------------S-GTGV---------INGVLHT--DTSK---T---------------------------NKIAH---------GQG----KLVGC----------------------------------------------------------EK----DNSK---------------------------------------ELIE---CLR---T------V------------------------------------------------PADEFRDSSDVTK-RTIANVTG------------INDI--TMPFQ----------------------------P------TL----DG--------------E--FI----KEDPSTI----------------------------------------------RT------F-NG---------------------------------------------------------------------------------------------------------------------------EE--LM------------------T-------------------GTTGDEGLF------------------FF-------FSLFP---NDD--SELSVN---------KTLY----------------------DSMF------------SMV--IPG---------------K-NQAVL-D---------MIKLIY----VDWDHA--------------------------------------DE---EN-ANYL----------------S---PLSQM-----AG-D------------------------------VFFVCP----SDVAARDY-YGA-----GL------------------------------N--TYMYQL-------TH-APAKSVW-------P-FKTG--------K-PLHG---------DDI-LFVF------------------------------------------------- 641
642 ----------------------------------------------------------------------------MVW----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FII-GS------GT------R---LYDATILSS-----LN----DVIVVT------I-N---YR-LG-------------ALGFFST--------GDDV---A-----P-G---NYGFLD--QVEA----------------------------------------------L-----------------------------G--WVQQN-----------------------------IAAFG---------------------GD------------------------------------------------------PNT----V-TL--F-G--QS-----------------AG-----------------------------A-ISIHY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VLSPM-------S---------------K---------------GLFKRTILQ-----------------------------------------------------------------------------------------S-GTAT---------IKGFMAQSDDASR---T---------------------------NIIAN---------GLG----KFVGC----------------------------------------------------------EK----DNSK---------------------------------------ELLE---CLR---A------V------------------------------------------------PADEFRDAFYVTK-LAIANMTK------------IKDM--MIPFP----------------------------P------TL----DG--------------E--FV----KEDPLNT---------------------------------------------ETK------F-NG---------------------------------------------------------------------------------------------------------------------------EE--LM------------------I-------------------GATTDEGFM------------------MY-------LPLFP---VHD--SEFTVN---------KTMY----------------------EAMY------------SML--ISD---------------K-NQAVL-D---------AVKLIY----VDWDHA--------------------------------------DE---ED-ANYL----------------S---ALCQM-----AG-D------------------------------MMFVCP----SDLAARAH-SAQ-----GI------------------------------N--TYLYQM-------TH-VPATTLW-------P-VKTG--------T-SLHA---------DDI-QFVFG------YPL--------------------------------------- 642
643 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GDDV---A-----P-G---NYGFLD--QVEA----------------------------------------------L-----------------------------R--WVQQN-----------------------------IAAFG---------------------GN------------------------------------------------------PNE----V-TI--F-G--ES-----------------AG-----------------------------A-ISIHY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VLSPL-------S---------------K---------------GLFKRAILQ-----------------------------------------------------------------------------------------S-GTAT---------MIGFFQS--DASK---T---------------------------NKIAH---------GQG----KIAGC----------------------------------------------------------EK----DNSK---------------------------------------ELIE---CLR---T------A------------------------------------------------PADKFRNSSDPES-GVIANATG------------LEDI--FVPFP----------------------------P------TM----DG--------------V--FL----TEDPKDAV-------------------------------------------RGNV------F-NG---------------------------------------------------------------------------------------------------------------------------EE--FM------------------I-------------------GTMADEGFM------------------MY-------FMLFP---DEH--SELTVN---------KTVY----------------------DEIY------------AMY--FLD---------------K-NQAVL-D---------VIKLIY----VDWDHA--------------------------------------DE---EN-ANYL----------------S---AMSQM-----AG-D------------------------------AFFVCP----SDEAARAF-YGA-----GF------------------------------D--TYLYQM-------TH-ASATTFW-------P-IKTG--------T-ALHG---------DDV-QFVFG------YTL--------------------------------------- 643
644 PVDKIQDEDC--------------------LHVSVYV--------PQP-----------S-N------DK--K-SVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LTY-GS------GT------M---LHDGTVLSA-----LN----DVIIVT------I-N---YR-LG-------------VFGFFST--------GDDV---A-----S-G---NYGFLD--QVEA----------------------------------------------L-----------------------------R--WVQQN-----------------------------IAAFG---------------------GD------------------------------------------------------PDN----V-TI--F-G--QS-----------------AG-----------------------------S-ISCHA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-MLSEM-------S---------------K---------------GLFNRAILQ-----------------------------------------------------------------------------------------S-GTAI---------IKGFFNT--DPVK---S---------------------------KRVAA---------GLG----HVVGC----------------------------------------------------------EK----DNTV---------------------------------------DLLK---CLR---S------L------------------------------------------------PAEEFLDADDPSK-GIIANVTG------------MDDL--MLPFL----------------------------P------NV----DG--------------I--FL----KEDPMVTA-------------------------------------------KSRP------F-ND---------------------------------------------------------------------------------------------------------------------------VD--LM------------------I-------------------GTMADEGMV------------------FI-------VGLFPE-AEDK--SDITMN---------KTTY----------------------DGMY------------PHI--IPEA--------------K-NDAVL-S---------MLELLY----VDWDHA--------------------------------------DD---DE-ANYV----------------D---AISQM-----AG-D------------------------------WMFVCP----SDTVARSH-VEG-----VR------------------------------T--TYLYQM-------TH-VPTNTLW-------P-IETW--------K-ANHG---------DDV-SLVFG------IPLF--SE-KQLALGGDETSMFKYP----------------- 644
645 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FG---------------------GD------------------------------------------------------PSR----V-TI--F-G--ES-----------------AG-----------------------------A-GSTHI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-TISPL-------S---------------K---------------GLFKRAIMQ-----------------------------------------------------------------------------------------S-GAAT---------IDGMWQY--NKTL---S---------------------------NLIAH---------GVG----KIVGC----------------------------------------------------------DK----DTSK---------------------------------------DLID---CIR---N------V------------------------------------------------PADQLRNISDPSN-GLLADALE------------MPGV--QLAFL----------------------------P------TI----DG--------------F--LI----KEDPMDTF------------------------------------------FKTKT------F-ND---------------------------------------------------------------------------------------------------------------------------VD--VM------------------F-------------------GTVSDEGMI------------------FL-------FSLFSD-AENE--GPLILN---------KTTY----------------------DAMY------------PNF--LFTI--------------QPNEAVL-D---------TIKLLY----VDWAHV--------------------------------------DE---EN-ANYL----------------D---ALSQM-----AS-D------------------------------IFFVCP----INRAARAS-AEA-----GL------------------------------N--TYVYQM-------TH-VPAMTIW-------P-LKTD--------T-AVHG---------DEL-GFVFG------------------------------------------------ 645
646 LVGTLHSRAG--------------------LVGALYS--------RAG-----------L-S------GI--K-SVMMW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LMS-GS------GT------E---MYDATILSA-----LN----DVIVVT------I-N---YR-LG-------------LFGLLST--------GDEE---V-----P-G---NVGFLD--QVEA----------------------------------------------L-----------------------------R--WIQQN-----------------------------IAAFG---------------------GD------------------------------------------------------SSR----V-TI--F-G--QS-----------------AG-----------------------------G-GSAHI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-TISPL-------S---------------K---------------GLFKRAIIQ-----------------------------------------------------------------------------------------S-GSAS---------LPGMWQY--NTTL---S---------------------------NLIAH---------GVG----KIVGC----------------------------------------------------------DE----NTSK---------------------------------------DLVD---CIR---N------V------------------------------------------------PADQLRNISDPSN-GLLANALG------------MPGV--QFAFL----------------------------P------TI----DG--------------Y--FI----TEDPMDTI------------------------------------------FKKKA------F-ND---------------------------------------------------------------------------------------------------------------------------VD--LM------------------I-------------------GTVSNEGMM------------------YL-------FSLFPD-AESE--GPLTLN---------KTTY----------------------EAMY------------PHF--FFTI--------------QPNEAVL-D---------MTKLLY----VDWAHV--------------------------------------DE---EN-ANYL----------------D---ALSQM-----TS-D------------------------------VFFICP----INRAVRAG-VEA-----GL------------------------------N--TYVYQM-------TH-VPAMTIW-------P-LKTG--------T-AVHG---------DEL-GFVFG------YNML--SE-KQMVLGGDNTTMFKWTTSEVD------------ 646
647 NPNTQVSEDC--------------------LYLNVWT----------P-------------------SPKPHKAAVMV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G---NYGMYD--QVLA----------------------------------------------L-----------------------------K--WMKSN-----------------------------IGTFG---------------------GD------------------------------------------------------PNR----V-TI--F-G--ES-----------------TG-----------------------------A-ASVGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPL-------S---------------E---------------PLFNRAILQ-----------------------------------------------------------------------------------------S-GTPD---------AEWAVMT------HGGA---------------------------ETKSQ---------ILG----SFHGC-----------------------------------------------------------NF----------------------------------------------SQSDFVDCLRN--V-------------------------------------------------------SADELSARE---RQFSEMPWT----------------------------------------------------P------IA----DG--------------K--YL----LYDPK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HSDEGRY------------------FILYGFVPGYEKDSTNLQTYENYLANVDYTNSDLNTCSRA--------------------------------------------------------------------------------AIKDHY----THWESP-------------------------------------------HDAVVNR----------------D---NLGDV-----ID-D------------------------------RLLICP----TVNFAHKY-AQT-------------------------------------NVNVYSYQY--------NIRDSQNPW---------PEWM--------A-VIHG---------DEI-QFVFG------------------------------------------------ 647
648 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NYGMYD--QVLA----------------------------------------------L-----------------------------K--WVKSN-----------------------------IGAFG---------------------GD------------------------------------------------------PNM----V-TI--F-G--ES-----------------AG-----------------------------A-ASVGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPL-------S---------------E---------------PLFNRAILQ-----------------------------------------------------------------------------------------S-GAPD---------ANWAVMT------HAQS---------------------------RQRSE---------TLG----LSHGC----------------------------------------------------------DDF----------------------------------------------EDRDFVDCLRC--I-------------------------------------------------------PADTLSANEWVTGNFNEFPWV----------------------------------------------------P------VV----DN--------------K--FL----TDEPK-RL------------------------------------------IRNGH------F-KK---------------------------------------------------------------------------------------------------------------------------AS--IM------------------A-------------------GVNGDEGTY------------------FILYQ-IPGYEIDTPSYQTYDNYLGNVDVVNYDLNMCSRS--------------------------------------------------------------------------------AIKDHY----SHWNML-------------------------------------------YDSVANR----------------D---ALDDV-----VG-D------------------------------RQFICP----TVDFAHKY-AQE-------------------------------------NVNVYTYKL--------DIRDSQNPW---------PQWM--------G-IMHG---------DDI-QFVFGMPLNPANGYTDE------------------------------------ 648
649 FDINDQSEDC--------------------LYLNIFV--------------------------PKS-IEKNKTFPVMFY----I-------H---------------------------------------------------------G--------------------G----S-------------------------------------------------------------------------------------------------N--RAGMGAMLPGDLLA-AY---GQIIVIN------F-N---YR-LG-------------LLGFLSSVENNFP-----------------G---NNGLLD--QVLA----------------------------------------------M-----------------------------K--WVNSN-----------------------------IQYFN---------------------GD------------------------------------------------------VSS----I-TI--V-G--HS-----------------AG-----------------------------A-GDTGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LVSPL-------T---------------K---------------GLFKNAILM-----------------------------------------------------------------------------------------S-GSPL---------AHWAMAMPNQYPGS--------------------------------------------NINSTI-------------------------------------------------------------------------------------------------------------------------LRIALNAADIRQI------------------------------------------------SVQDLIAIESIMSKFLPFSVVPY--------------------------------------------------P-----AVV----DN--------------Y--YL----TEQPR-TS------------------------------------------FKNGDFHGEAFF------------------------------------------------------------------------------------------------------------------------------------------------------L-------------------SFTADESFA-DL-----------------GLFKNASFPGFLVRYEPFYPKICNFLD-------------------------------------------------------------------------------------------VLTAAY-SDVN------PSG-----------------------------------------------------------------KRLIEA-----EA-D------------------------------MLFYAGMTELADLLSDSEAKPE----------------------------------------VTVLEYDIIMPYLNN-----------------PKWQ--------G-VNHG---------QDI-FYLFG------------------------------------------------ 649
650 FPSQEMNEDC--------------------LHLDVHT----------P---------------SH-NPGEN--LAVMVY----F-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------Y---VN------GA------A--GYYDGSPY-----A-LF---QNVVLVA------A-N---YR-LG-------------ALGYLST--------GD--EAAF-------G---NFALLD--QQMA----------------------------------------------L-----------------------------Q--WVHNH-----------------------------IKLFG---------------------GD------------------------------------------------------PNR----V-TI--F-G--ES-----------------AG-----------------------------A-VNVIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LQSHL-------S---------------R---------------GFFHRAISQ-----------------------------------------------------------------------------------------S-GVAH-------S----PIM-M---SKNP-----------------------------HHVAQ---------RLA----KKLLC----------------------------------------------------------P----TSS-----------------------------------------NK-ELVECLRT--K-------------------------------------------------------AADDIV---K----VDMTDPDIPTLPFA---------------------------------------------P------VV----DG--------------F--FI----EEEPLEA--------------------LMTGKLT--------AGPELLIGVNN---HEGG-F-SN---------------------------------------------------------------------------------------------------------------------------LA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NRMHAKL--LTDFNVQSFRKLLQFELQKFIPGDLSDLIHSIELMYGGKHGMTD----------------KD----ALYQLTEV-----VG-D------------------------------LIYVVPALAL--------AESRTALGG----------------------------------KVYFYEY----------QHRMSCSRAPSW------V---------R-ADHG---------DEE-AIVVG------------FPFLEEHELGRLHFTPEE------------------ 650
651 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YDSVPLVA-----MS----DIIVVA------V-N---YR-LG-------------VFGFLTT--------GDDV---A-----P-G---NMGMKD--QIMA----------------------------------------------L-----------------------------K--WVQEN-----------------------------IEAFG---------------------GD------------------------------------------------------PGR----V-TI--A-G--QS-----------------AG-----------------------------G-ASVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-MLSPL-------S---------------E---------------GLFHRAIMQ-----------------------------------------------------------------------------------------S-GNAI---------CPFAWSP---MDV---C---------------------------VEDTY---------EFA----ASLNC-----------------------------------------------------------TTQ---------------------------------------------NSRLMLECLQ---E------V------------------------------------------------HADVLLQE----Q-RYGSG-----------------------YFAK---------------------------P------VV----DG--------------H--FL----PDNPI-EM------------------------------------------VKRHR------F-QN---------------------------------------------------------------------------------------------------------------------------LP--TL------------------I-------------------GTNEDEGSN------------------NA------MYQFFPGSLFSK----PSMN---------ISEF----------------------RSIL-PRNLWYA------K----------------------DPVEV-T---------AVEHWY----VDWSIA--------------------------------------DN---ET-ADQF----------------D---ALIRL-----GT-D------------------------------QAFACP----TEYLVRGL-QSV-----G--------------------------------VEVYRYEM-------TH-DPSWSLFG-----GV-PKWM--------G-AAHG---------EDI-QYVFA------WDLN--PS---------------------------------- 651
652 ---REVNEDC--------------------LYLSIYT--------PSP-------------KPT----SL--V-PVFVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------YVI-GG------GS------E--LIYQPLPMVV-----LS----DIIVVN------V-N---YR-LG-------------AFGYFTT--------GDDV---A-----R-G---NYGMLD--QVMA----------------------------------------------L-----------------------------Q--WVQDN-----------------------------IEAFG---------------------GD------------------------------------------------------PRR----V-TI--G-G--ES-----------------AG-----------------------------G-SSVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-SLSPL-------T---------------D---------------GLFHQTIMQ-----------------------------------------------------------------------------------------S-GNAL---------CPWSWAT---QER---G---------------------------TEVGR---------ELA----ETFGC-----------------------------------------------------------PTE---------------------------------------------DSSAMIACLR---Q------V------------------------------------------------PERDLTQA----Q-FYLSS-----------------------VLST---------------------------P------IV----DG--------------Y--FL----LDHPM-EL------------------------------------------INRRQ------F-KI---------------------------------------------------------------------------------------------------------------------------QP--TL------------------M-------------------GTNEDEGAG------------------NA------L-SLFPGSTRSE--TPPVMN---------ISFF----------------------RSLI-PSQTYND------A----------------------TDIEL-A---------AIENEY----VDWSVA--------------------------------------DD---PTDGNQI----------------D---GFIRL-----NT-D------------------------------ISFSCP----TEYVARAL-EAA-----G--------------------------------AEIYRYEM-------TH-DPSWSVYA-----GI-PKWL--------G-AAHA---------EDL-QYVFT------WGLN--PAPIARIVGQSD------------------------ 652
653 -----ENEDC--------------------LYLSVHT--------SSE-------------RPS----N---A-PVMIW----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FTG-GS------GS------S--SSYDPYPYFG-----LT---ADYVVVH------I-N---YR-LG-------------VLGFLTT--------GDAA---S-----P-G---NYGMYD--QVMA----------------------------------------------L-----------------------------E--WVQEN-----------------------------IAAFG---------------------GD------------------------------------------------------PSR----V-TI--M-G--ES-----------------AG-----------------------------A-ASVGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LVSPL-------S---------------K---------------DLFHQSIMQ-----------------------------------------------------------------------------------------S-GNAL---------CPWAVDT--NIDR---Q---------------------------IGFTM---------EIA----DMVNC-----------------------------------------------------------TTT---------------------------------------------DNQALVECLK---N------V------------------------------------------------EINDLLMA----Q-ATLVGKYL-----------------HVELLFV---------------------------P------VV----DG--------------A--FL----PDVPL-EL------------------------------------------IKRGE------F-KS---------------------------------------------------------------------------------------------------------------------------VP--TL------------------L-------------------GTNREEGTL------------------IA------L-RAYPLYIGSR--NPPTTT---------LQEF----------------------RDFL-PDYLYE-------Y----------------------TPLVA-S---------AVEQWY----IDWKLA--------------------------------------DD---PE-ADQF----------------E---AFVNL-----QT-D------------------------------QVFACS----TEAMARAL-EES-----G--------------------------------APVFRYEM-------TH-DPSSLIV---------PGWL--------G-AGHG---------EDL-QFVFA------RGLS--STGGRQTHQE-------------------------- 653
654 --NKGENEDC--------------------LYLGVHT--------SSP-------------RPS----S---A-PVMVW----L-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FTL-GG------GT------W--TAYDPYPLIA-----IS---PDIVVVN------V-N---YR-LG-------------VLGFLTT--------GDSA---S-----I-G---NFGMLD--QVMA----------------------------------------------L-----------------------------R--WVQEN-----------------------------IAAFG---------------------GD------------------------------------------------------PSR----V-TI--M-G--ES-----------------AG-----------------------------A-ASVGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPL-------S---------------Q---------------GLFHQAIME-----------------------------------------------------------------------------------------S-GNAL---------CPWAVDT--NIDR---Q---------------------------IGFTN---------EIA----DTVNC-----------------------------------------------------------TTT---------------------------------------------DNQALVECLR---N------T------------------------------------------------DVIVLLRT----Q-ALLVGKYL-----------------FNELLFV---------------------------P------VV----DG--------------A--FL----PDIPI-DM------------------------------------------IKREE------F-HS---------------------------------------------------------------------------------------------------------------------------VP--TL------------------L-------------------GTNEDEGTL------------------IA------L-RANPLYLRRK--DPPTMT---------LREF----------------------RESL-PDYLYY-------Y----------------------TPLLA-S---------AVEQWY----IDWTVA--------------------------------------DD---SS-ADQL----------------E---AFVRL-----NT-D------------------------------QVFSCP----TEITARAL-EGS-----Q--------------------------------ATVYRYEM-------TH-DPSRSVVG-----ER-PGWL--------R-AGHG---------EEL-QYVFG------WGIK--SR-RNQT----------------------------- 654
655 ----NLDEDC--------------------LYLSVHT--------SSP-------------RPN----N---G-PVVVW----F-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------YSL-GA------GS------N--TVYEPLPLIA-----FA---PDIVFVG------V-N---YR-LG-------------LYGFMTT--------GDSA---A-----P-G---NYGMYD--QVMA----------------------------------------------L-----------------------------Q--WVQDN-----------------------------IAAFG---------------------GN------------------------------------------------------PNR----V-TI--M-G--ES-----------------AG-----------------------------A-ASVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-MLSPL-------S---------------E---------------GLFHQAIME-----------------------------------------------------------------------------------------S-GNAL---------CPWAVDT--DMER---Q---------------------------VGFTR---------EIA----DLVNC-----------------------------------------------------------TEE---------------------------------------------DSEALLTCLR---E------V------------------------------------------------EEKDLTRA----Q-ITLTAKYL-----------------TNEMLYA---------------------------P------VV----DY--------------A--FL----PDIPM-EI------------------------------------------VRRQE------F-HK---------------------------------------------------------------------------------------------------------------------------VP--TL------------------I-------------------GTNEDEGTL------------------IA------V-RVYPLYVVRP--NPPNIS---------LSEF----------------------RELI-PLYLFY-------N----------------------SPMMA-S---------AVEQWY----IDWTQA--------------------------------------DD---TS-ANHI----------------N---SFINW-----NT-D------------------------------QMFACP----AEAMARAV-ADT-----G--------------------------------APVYRYEM-------TH-DPSKAVFD-----ST-PSWY--------G-AGHA---------VEL-QYVFG------------------------------------------------ 655
656 ---REVDEDC--------------------LYLAVHT--------SSP-------------RPS----N---A-PVVVW----F-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------YTI-GA------GS------A--TYYEPLPLIA-----LA---PDIVFVT------V-N---YR-LG-------------VYGFLTT--------GDSV---S-----P-G---NYGMFD--QVMA----------------------------------------------L-----------------------------E--WVQTN-----------------------------IDAFG---------------------GD------------------------------------------------------PSR----V-TI--M-G--ES-----------------AG-----------------------------A-SSAGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPL-------S---------------D---------------GLFHQVIMQ-----------------------------------------------------------------------------------------S-GNAL---------CPWAVDT--VIDR---Q---------------------------VGFTR---------EIA----DQVNC-----------------------------------------------------------TDL---------------------------------------------DNELVVECLR---D------V------------------------------------------------DEPVLTQA----Q-ATLTLKYL-----------------TNELLFT---------------------------P------VV----DQ--------------A--FI----PDLPV-EI------------------------------------------IKRQE------F-RS---------------------------------------------------------------------------------------------------------------------------VP--TL------------------L-------------------GTNEDEGTL------------------IA------L-RAYPSYVLRQ--NPPTVT---------LEDF----------------------IKLL-PDYLFY-------Y----------------------TPMLA-T---------ATEQWY----VDWRQA--------------------------------------DD---SA-ANQV----------------N---AFIKL-----NT-D------------------------------QMFACP----TEAMARAM-VDT-----G--------------------------------APVYRYEM-------TH-DPTMSIFI-----GL-PGWL--------G-AGHA---------EEL-QFVF------------------------------------------------- 656
657 -------EDC--------------------LYLNVYA--------PNP-------------TPD----N---A-AVMVW----F-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------YNA-GT------AG------R--YMFSGIPLAA-----VG----NVIVVT------A-N---YR-LG-------------SLGFLST--------GDAA---A-----P-G---NYGSFD--QVMA----------------------------------------------L-----------------------------R--WVQEN-----------------------------IASFG---------------------GD------------------------------------------------------PTR----V-TI--F-G--ES-----------------AG-----------------------------A-TSVGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VVSKE-------S---------------E---------------DLFTWAIMQ-----------------------------------------------------------------------------------------S-GSTM---------TPFAYNP--DLNA---A---------------------------REDAF---------KLG----SNVGC-----------------------------------------------------------DEA---------------------------------------------DSNDLIACLR---T------KS-----------------------------------------------ASEVLAGG----L-QFGFLSAP----------------------------------------------------------VV----DG--------------R--FL----ITDPV-QM------------------------------------------LAKGD------F-KH---------------------------------------------------------------------------------------------------------------------------RN--IL------------------L-------------------GSNHDEGTL------------------WA-------LGIYPDYTLSK--SAPYMS---------RADY---------------------------DEHRDDFLTGS--L----------------------NDIAL-K---------AMDQQY----IDWSSA--------------------------------------DN---LD-TDYL----------------D---LLVRQ-----IT-D------------------------------ETFTAP----ADATARAF-YQH-----G-------------------------------AGDVYMYEL-------TH-VPSVPAYSLNL--LG-PGWL--------G-VTHG---------EDL-QFVFG------------------------------------------------ 657
658 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MA----------------------------------------------L-----------------------------R--WVQEN-----------------------------IASFG---------------------GD------------------------------------------------------PTR----V-TI--F-G--ES-----------------AG-----------------------------A-TSVGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VMSKE-------S---------------E---------------DLFTWAIMQ-----------------------------------------------------------------------------------------S-GSTM---------TPFAYNP--DLNA---A---------------------------REDAF---------KLG----SNVGC-----------------------------------------------------------DEA---------------------------------------------DSNDLIACLR---T------KS-----------------------------------------------ASEVLAGG----L-QFGFLSAP----------------------------------------------------------VV----DG--------------R--FL----TTDPV-QM------------------------------------------LAKGD------F-KH---------------------------------------------------------------------------------------------------------------------------RN--IL------------------L-------------------GSNHDEGTL------------------WA-------LGIYPDYTLSK--SAPYMS---------RADY---------------------------DEHRDDFLTGS--L----------------------NDIAL-K---------AMDQQY----IDWSSA--------------------------------------DN---LD-TDYL----------------D---LLVRQ-----IT-D------------------------------ETFTAP----ADATARAF-YQH-----G-------------------------------AGDVYMYEL-------TH-VPSVPAYSLNL--LG-PGWL--------G-VTHG---------EDL-QFVFG------------------------------------------------ 658
659 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IA--------SDAA---A-----P-G---NYGSFD--QVMA----------------------------------------------L-----------------------------R--WVQEN-----------------------------IASFG---------------------GD------------------------------------------------------PTR----V-TI--F-G--ES-----------------AG-----------------------------A-TSVGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VMSKE-------S---------------E---------------DLFTWAIMQ-----------------------------------------------------------------------------------------S-GSTM---------TPFAYNP--DLNA---A---------------------------REDAF---------KLG----SNVGC-----------------------------------------------------------DEA---------------------------------------------DSNDLIACLR---T------KSASEVLAGGLQVAGYIRVTFKFEMTD---------SYDLVIACLRTKYASEVLAGG----L-QFGFLSAP----------------------------------------------------------VV----DG--------------R--FL----TTDPV-QM------------------------------------------LAKGD------F-KH---------------------------------------------------------------------------------------------------------------------------RN--IL------------------L-------------------GSNHDEGTL------------------WA-------LGIYPDYTLSK--SAPYMS---------RADY---------------------------DEHRDDFLTGS--L----------------------NDIAL-K---------AMDQQY----IDWSSA--------------------------------------DN---LD-TDYL----------------D---LLVRQ-----IT-D------------------------------ETFTAP----ADATARAF-YQH-----G-------------------------------AGDVYMYEL-------TH-VPSVPAYSLNL--LG-PGWL--------G-VTHG---------EDL-QFVFG------------------------------------------------ 659
660 GRRSGKDEDC--------------------LYLNVYV--------PQP-------------VTD----F---K-AVMVW----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------YNA-GA------GG------R--LWYSGTPLAA-----FG----DVIVVT------I-N---YR-LG-------------PFGFLST--------GDES---A-----P-G---NFGMMD--QIIA----------------------------------------------L-----------------------------Q--WVQDN-----------------------------IQNFG---------------------GD------------------------------------------------------PTR----V-TL--F-G--QS-----------------AG-----------------------------A-TSIGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPL-------S---------------Q---------------PLFKYAIMQ-----------------------------------------------------------------------------------------S-GSTL---------TPFAYTD--DKER---S---------------------------REEAF---------LVG----ENLGC-----------------------------------------------------------RTT---------------------------------------------SSRQLISCLR---T------KS-----------------------------------------------TSQILASS----L-SLIFLSAP----------------------------------------------------------VI----DG--------------V--FL----PDHPE-VL------------------------------------------VQTGQ------F-KR---------------------------------------------------------------------------------------------------------------------------TN--IL------------------I-------------------GTNHDEGTA------------------WA-------LSAFPRDINSN--EKPNMY---------RDLY---------------------------DVWHGRYTYGL--T----------------------NDIIL-R---------SMDQEY----LNWKEA--------------------------------------DD---PE-ADYL----------------D---AFVAQ-----IT-D------------------------------QTFVAP----ADTLSRAY-ATQ-----N-------------------------------GGDVYLYQM-------TH-VPSASVYELTPRDIG-PGWL--------G-VTHG---------EEF-QFVFG------WSFI--PDISDSRPQLPPIE---------------------- 660
661 TIMESMSEDC--------------------LYLNVYS--------PSP-------------KPT----N---A-TVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FTS-GT------AN------Q--YDYYGVPLVA-----VG----DVIVVT------I-N---YR-LG-------------VFAKFTT--------KDAE---A-----P-G---NVGMLD--QVAA----------------------------------------------L-----------------------------Q--WINDN-----------------------------IEAFG---------------------GD------------------------------------------------------KDR----I-TL--F-G--ES-----------------AG-----------------------------G-AAVEY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-TLSKR-------S---------------R---------------GLFNQAIIQGVPFAEPPRRFKPPVAKLPWDGPLNVTEFKDACTQLPIFGTIMESMSEDSFGGDKDRITLFGESAGGAAVEYLTLSKRSRGLFNQAIIES-GSTV---------PNWSFDP--RPAEM--E---------------------------VQDAK---------NLG----EALGC-----------------------------------------------------------DTS---------------------------------------------PSSALIACLE----------------------------------------------------------------TKT----A-NEIINSSL-----------------LAYSFCP---------------------------V------SV----DG--------------D--FL----DDEPA-NL------------------------------------------YKNKD------F-KR---------------------------------------------------------------------------------------------------------------------------CP--IL------------------T-------------------GTNRDEGTL------------------FL-------IAVFPTDAPNP--PRPEVN---------TSGL----------------------DVII-RSLMVTYGI----T----------------------EDILI-A---------AIRQEY----TDWTIA--------------------------------------DN---SS-ANQM----------------P---SYIEC-----AG-D------------------------------QGFSCP----SDQFARYH-AGV-----G--------------------------------DTVFKYFF-------TH-EPSRSVF---EGFPG---WF--------G-AGHA---------EEV-TFVFG------APFI--EQLSDRDIYMLTD----------------------- 661
662 ----FMDEDC--------------------LYLNIFV--------PNP-------------KPH----K---A-AVMLW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FES-GT------AS------T--YDFYGVPLVA-----V--------------------------------------------------------DDDK---A-----T-G---NYGMLD--QVAA----------------------------------------------L-----------------------------S--WVKSN-----------------------------IEAFG---------------------GD------------------------------------------------------SER----I-TL--F-G--ES-----------------AG-----------------------------A-SS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-ASAF---------SNFAYQP--DRSA---E---------------------------KRYAE---------ETG----EELGC-----------------------------------------------------------DSS---------------------------------------------SSNELIECLK---G------I------------------------------------------------NARRLRAV----A-DRVYPA-Y-----------------------S---------------------------V------SV----DG--------------Y--FL----ADTPA-NL------------------------------------------YRRGD------V-QH---------------------------------------------------------------------------------------------------------------------------PT--LL------------------I-------------------GFNKDEGSI------------------RV-------FGENLAYAGST--KGPPIN---------KSNP----------------------EESV-KASSAKYGL----G----------------------DSILQ-E---------AMLQEY----TDWAKA--------------------------------------DD---PD-AEFL----------------D---ELIHF-----HG-D------------------------------FDFICP----TITTSRLH-AEA-----G--------------------------------DTVFQYFM-------TH-EPSMSYLQYRNLLPS-TPWL--------K-AGHT---------EDL-TFVWG------VPFI--KELDDVHGYNMTAE---------------------- 662
663 ----------------------------------------------------------------------------MVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FSV-GT------GS------S--YGRYGVPLVA-----VG---QDVIIVT------L-N---YR-LM-------------VWGVFNT--------GDDV---A-----T-G---NYGLLD--QQLA----------------------------------------------L-----------------------------Q--WVQDN-----------------------------IGAFG---------------------GD------------------------------------------------------PST----V-TL--F-G--ES-----------------AG-----------------------------A-ASVGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSEG-------S---------------K---------------DLFNQAIMQ-----------------------------------------------------------------------------------------S-GTSL---------SPWAFRH--EPEA---D---------------------------REEAI---------ALG----AKVGC-----------------------------------------------------------DFT---------------------------------------------DSTQLVDCLR---T------V------------------------------------------------DAVTLMNA----F-WQVYTQSY---------------------------------------------------I------RV----DG--------------I--FL----KDSPA-NL------------------------------------------YASSS------F-KK---------------------------------------------------------------------------------------------------------------------------AA--IL------------------A-------------------GYNQDEGYI------------------AA-------KDLFSEYQGDE--V-PTMP---------KSMY----------------------TAAL-PNALTGN------T----------------------EDIVM-R---------SVDQQY----IDWTQA--------------------------------------DN---TS-ADYL----------------T---AFTEA-----VG-D------------------------------QQFSCP----TDHLIRAH-AQS-----G--------------------------------DTVFQYFM-------TH-APSTSYFQSGPGGSG-PGWL--------G-ATHT---------EDI-QFVFG------WP---------------------------------------- 663
664 -YFPEQDEDC--------------------LYLNVYA--------PNP-------------KPS----G---A-AVMVY----I-------H---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------FSS-GS------AM------V--YDFYGVPLVA-----VG----DVIVVV------L-N---YR-LG-------------VFAKFTT--------KSDA---A-----P-G---NIGMLD--QVVA----------------------------------------------L-----------------------------Q--WVKSN-----------------------------IEAFG---------------------GD------------------------------------------------------PNR----I-TI--F-G--ES-----------------SG-----------------------------S-ASVNF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSKL-------S---------------H---------------GLFQQAIMQ-----------------------------------------------------------------------------------------S-GVAS---------STWAFED--NPGK---E---------------------------VENAH---------KLG----QAFRC-----------------------------------------------------------DLT---------------------------------------------PLSDLVACLQ---A------V------------------------------------------------DPNELWTV----A-NQVYDGSY-----------------------H---------------------------V------YV----DG--------------M--FL----EDTPQ-NL------------------------------------------YAKGE------F-TR---------------------------------------------------------------------------------------------------------------------------AP--IL------------------A-------------------GVTQDEGTY------------------DI------WVKFFWPYAYSE--TPPPFN---------QSQL----------------------EDYL-RSGLRNENVLSSDS----------------------ADILL-D---------AVLHEY----IDWTIA--------------------------------------DD---PD-ADFF----------------Q---PAVDA-----IG-D------------------------------VSIKCP----MDSILRAH-VSA-----G--------------------------------DPVYKYVF-------KYPVTTMSYFHVVGVLPL-TPWL--------G-AGHA---------EDL-LYVWG------VPFI--DQLDNVHGQN-------------------------- 664
665 LYYPVMSEDC--------------------LYLNVYS--------PSP-------------KSS----G---L-PVMVW----I-------H---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------FSA-GS------AM------D--YDYYGVPMVA-----VG----DVIVVT------I-N---YR-LA-------------IFAQFST--------EDFE---A-----P-G---NYGMLD--QVAA----------------------------------------------L-----------------------------E--WTYNN-----------------------------IEAFG---------------------GD------------------------------------------------------KDR----I-TI--F-G--ES-----------------AG-----------------------------G-ASVSF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VLSKL-------S---------------R---------------GFFSQAIYQ-----------------------------------------------------------------------------------------S-GTAL---------NPWAFKH--DPAG---E---------------------------TEKAQ---------ELG----RSMGC----------------------------------------------------------DDVS---------------------------------------------STAALVSCLR---N------VQ-----------------------------------------------DPAALTQA----A-DVIYQAAY-----------------------P---------------------------V------TL----DG--------------T--FL----EDTPT-NL------------------------------------------YKMGD------F-AN---------------------------------------------------------------------------------------------------------------------------VP--VM------------------V-------------------GFNKDEGTL------------------YI-------LQVLPESFGSP--LPPYIN---------RTSF----------------------ENFI-RYVMIYYDR----N----------------------DEIVN-D---------AVFQEY----IDWTMA--------------------------------------DD---GA-ADYF----------------Q---STVDF-----GT-D------------------------------FDFVCT----SDMVMRVH-AQA-----G--------------------------------GTVYKYYM-------TH-RPSESLFKYGDVIPN-IPWL--------G-AGHG---------EEL-TFVWG------HPFI--AELKDIHGHN-------------------------- 665
666 LYYPVMSEDC--------------------LYLNVYT--------PSP-------------KPS----G---I-PVMVW----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FSS-GS------AM------T--YDYYGVPLVA-----VG----DVIVVT------I-N---YR-LA-------------IFAQFST--------EDFE---A-----P-G---NYGMLD--QVAA----------------------------------------------L-----------------------------E--WIYNN-----------------------------IEAFG---------------------GN------------------------------------------------------KDR----I-TI--F-G--ES-----------------AG-----------------------------G-ASVSF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VLSKL-------S---------------R---------------GFFSQAIYQ-----------------------------------------------------------------------------------------S-GTAF---------NPWAFKH--NPAE---E---------------------------TEKAQ---------ELG----RSMGC----------------------------------------------------------DEVS---------------------------------------------STAALVSCLR---N------VQ-----------------------------------------------DPVVLAQA----A-DAIYQAAY-----------------------P---------------------------V------TL----DG--------------T--FL----EDTPT-NL------------------------------------------YKMGD------F-AN---------------------------------------------------------------------------------------------------------------------------IP--IM------------------M-------------------GFNKDEGTL------------------YI-------LQVLPESFGSP--LPPYIN---------RTSF----------------------ENFI-RYVMIAYDR----N----------------------DEIVN-D---------AVFQEY----IDWTMA--------------------------------------DD---SA-ADYF----------------Q---SMVDF-----GG-D------------------------------FDFVCT----SDMVMRMH-TQA-----G--------------------------------GTVYKYYM-------TH-RPSESVFKYGDVVPS-VPWL--------G-AGHG---------EEL-TFVWG------HPFI--EELKDIHGHN-------------------------- 666
667 -FYPVISEDC--------------------LYLNVYT--------PSP-------------KPS----G---I-PVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FSI-GT------VM------D--YEYYGVPLVA-----VG----DVIVVT------I-N---YR-LA-------------IFAQFST--------EDEE---S-----P-G---NYGMLD--QVAA----------------------------------------------L-----------------------------E--WVYNN-----------------------------IEAFG---------------------GD------------------------------------------------------KNR----I-TI--F-G--ES-----------------AG-----------------------------S-ASVSF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LVSKL-------S---------------R---------------QFFNQAIYQ-----------------------------------------------------------------------------------------S-GTVF---------SPWAFKD--DPVA---E---------------------------LEKAQ---------ELG----REIGC----------------------------------------------------------EDTV---------------------------------------------SSSALVSCLR---N------A------------------------------------------------DAVELSTA----A-DKVYESQY-----------------------P---------------------------V------TL----DG--------------F--FL----DDSPT-NV------------------------------------------YKMGD------F-AN---------------------------------------------------------------------------------------------------------------------------VP--IL------------------I-------------------GFNKDEGTL------------------IP-------FASFPAYVGSP--TPPPIN---------RTYF----------------------EGVV-KQILTNYGK----D----------------------DEIVY-D---------AVLQEY----IDWTMA--------------------------------------DD---PK-SDYF----------------Q---SWVNF-----GT-D------------------------------SDFACP----SDFVMRRH-VEA-----G--------------------------------GTVYKYYM-------TH-APSKSILAYGDQFPS-SPWL--------G-AGHA---------EDL-TFVWG------QPFI--DELYHIHGHN-------------------------- 667
668 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E---S-----P-G---NYGMLD--QVAA----------------------------------------------L-----------------------------E--WVYNN-----------------------------IEAFG---------------------GD------------------------------------------------------KNR----I-TI--F-G--ES-----------------SG-----------------------------S-ASVSF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LVSKL-------S---------------R---------------QFFNQAIHQ-----------------------------------------------------------------------------------------S-GTVF---------SPWAFKD--DPVA---E---------------------------LEKAQ---------ELG----REMGC----------------------------------------------------------EDTV---------------------------------------------SSSALVSCLR---D------A------------------------------------------------NAVELSTA----A-DKVYGSQY-----------------------P---------------------------V------TL----DG--------------S--FL----VDSPT-NV------------------------------------------YTMGD------F-AN---------------------------------------------------------------------------------------------------------------------------VP--IL------------------I-------------------GFNKDEGTL------------------NP-------FFFLPAYIGSP--TPPPVN---------RTYF----------------------EGVV-RQILTNYGK----D----------------------DEIVY-D---------AVLQEY----IDWTMA--------------------------------------DD---PE-SDYF----------------Q---SWVNF-----GT-D------------------------------SDFACP----SDFVMRRH-VEA-----G--------------------------------GNVYKYYM-------TH-APSKSFFANGDQSPS-TPWL--------G-AGHA---------EDL-TFVWG------HPFI--DELYHIHGH--------------------------- 668
669 -FYPVISEDC--------------------LYLNVYT--------PSP-------------KPS----G---M-PVMVW----I-------H---------------------------------------------------------G--------------------G----N-----------------------------------------------------------------------------FVA-GT------AM------S--YDYYGVPLVA-----FG----DVIVVT------L-N---YR-LA-------------IFAHFST--------EDTE---S-----P-G---NYGMLD--QAAA----------------------------------------------L-----------------------------K--WVYNN-----------------------------IEAFG---------------------GD------------------------------------------------------KNQ----I-TL--F-G--GS-----------------AG-----------------------------S-SSVNF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-ILSEL-------S---------------R---------------GFFNQAILQ-----------------------------------------------------------------------------------------S-GTAI---------GNGAFKH--DPVA---E---------------------------LEKAQ---------ELG----REMGC----------------------------------------------------------EDVV---------------------------------------------STSALVSCLR---E------VE-----------------------------------------------DPVALSTA----A-DKVYAEGY-----------------------P---------------------------V------TM----DG--------------T--FL----KETPT-NL------------------------------------------YKMGN------F-AN---------------------------------------------------------------------------------------------------------------------------VP--IL------------------I-------------------GFNKDEGTL------------------VP-------YIFYPDYHGGP--TAPPIN---------RNAF----------------------ENII-KGSMANNGR----D----------------------DEIVY-D---------AVFQEY----IDWTMA--------------------------------------DD---PE-SDYF----------------Q---SWVNF-----GT-D------------------------------SNFACP----SDSVMRRH-VEA-----G--------------------------------VTVYKYYM-------TH-APSKSVRMYGDALPN-TPWL--------G-AGHA---------EET-IFVWG------LPFI--DELYYYRGHN-------------------------- 669
670 --YPQQSEDC--------------------LYLNVYV--------PSP-------------KPS----N---A-AVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FSE-GS------SS------S--SAFTGGPIVS-----VG----DVILVT------I-S---YR-LS-------------IFATFTT--------KDNV---A-----P-G---NFGMLD--QVAA----------------------------------------------L-----------------------------R--WVYEN-----------------------------IEAFG---------------------GD------------------------------------------------------RER----I-TI--F-G--VS-----------------AG-----------------------------A-ASVSF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-TLSKL-------S---------------R---------------DYFSQAILQ-----------------------------------------------------------------------------------------S-GSAL---------SVWAYKD--NAES---E---------------------------MTKVQ---------SLA----TAMDC-----------------------------------------------------------DAE---------------------------------------------NTSALVQCLR---S------K------------------------------------------------EAEALRAA----A-SKIYTSNY---------------------------------------------------V------TL----DG--------------N--FL----EDSPL-NL------------------------------------------YMKND------F-KK---------------------------------------------------------------------------------------------------------------------------LP--MI------------------A-------------------GFTKDEGTL------------------LT-------LS------GTL--PTPPLS---------GKGF----------------------KRII-AAFVQEYGI----T----------------------SEDVL-G---------VVLQEY----IDWTIS--------------------------------------DD---PD-ADYF----------------Q---ATVDF-----IT-D------------------------------THFACA----VDSELRFH-AGG-----S--------------------------------SPLYEYFF-------TH-VPTQSISTLFEE-PK--PWL--------G-AGHG---------EDV-PLVFG------WPFI--EDLVTYTGFN-------------------------- 670
671 ------DEDC--------------------LYLNVYR----------P-----------EIRKS-----A---LPVMVY----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FFG-GSAGPGVTGP----------EY----FMD-----SG----EVILVT------M-A---YR-LG-------------PFGFLST--------QDAV---------MSG---NFGLKD--QNLA----------------------------------------------L-----------------------------R--WVQRN-----------------------------IRFFG---------------------GD------------------------------------------------------PQR----V-TI--F-G--QS-----------------AG-----------------------------G-VAAHM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSPR-------S---------------H---------------GLFHRVISM-----------------------------------------------------------------------------------------S-GTAN---------VPFAIAE-----QP------------------------------LEQAR---------LLA----EFADV----------------------------------------------------------PDARNL-------------------------------------------STVKLTKALRR--I-------------------------------------------------------NATKLLNA--------GDGLKYWDVDHMTNFR-----------------------------------------PVVEEGLEV----DA-----------------FL----NAHPM-DM------------------------------------------LAQG-MP------TS---------------------------------------------------------------------------------------------------------------------------IP--LL------------------L-------------------GTVPGEGAVR-------VV-------NIL-----------------------------------GNETLRQSFNLRFDELLQE---LLEFPASFSQDRRE-------KMMD------------------------------------LLVEVY-FQGQHEVNE------------------------------------------------------------------LTVQGFMNL-----IS-D------------------------------RGFKQP-LYNTIH--KNV-CHT-------------------------------------PNPVYLYSF-------NYQGP---LS-------YASAYTSANVTGKYG-VVHC---------DDL-LYLFR------SPLLF----PDFQRNSTE------------------------ 671
672 ----------------------------------VYA--------------------------PKV-KSTRTPLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FFF-GN------GN------S--DFHFPAKL-------ME---QEVIVVT------L-N---YR-LG-------------ALGFLSL----------PEEGIH-------G---NMGLKD--QRLA----------------------------------------------L-----------------------------E--WVQEN-----------------------------IASFN---------------------GD------------------------------------------------------PNN----V-TL--F-G--ES-----------------AG-----------------------------G-SSVHL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-TFARH-------A---------------K---------------RLFHKAIMQ-----------------------------------------------------------------------------------------S-GTAN---------MEWVFQNEAPAKTR--------------------------------------------RLA----ELLGG----------------------------------------------------------GDFGG--------------------------------------------DSKALLTFLQS--E-------------------------------------------------------KATPTAILANTLKVLSPDERRRHLPFAFK--------------------------------------------P------VV----ED----------SS-SPDRFL----EQDIM-EL------------------------------------------MHKKDCLGS---------------------------------------------------------------------------------------------------------------------------------MP--VI------------------M-------------------GYNSAEGLA-----------IVVKAKQKLEAYEDDLARLVPRNLVLD-PQAPEAQ--------------------------------------------------------------------------------------------EAASDI------------------------------------------------RAFFFNGQALSK----------------ENMDNLVDL-----FS-D------------------------------YHFSMD----LQRAVEIHASCQT------------------------------------QSPLYFYRLDYVGGR--N-----------------LYKKIFQNEDLRG-VAHA---------DDI-CYLFQM------AGDETEMNRDD------------------------------ 672
673 KSFSDVSEDC--------------------LYLNVFA----------P-----------KNVSS-----PDQRFPVMVW----I-------H---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------FRY-GS------GS----------EYDGRILAA-----KG----EVVVVT------I-N---YR-LG-------------ALGFLST--------DDSV---------TSG---NQGLLD--QVMA----------------------------------------------L-----------------------------K--WVNRN-----------------------------IQHFG---------------------GN------------------------------------------------------PSQ----V-TL--F-G--QS-----------------AG-----------------------------G-SAVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-IFSRL-------S---------------E---------------GLFQAVIAQ-----------------------------------------------------------------------------------------S-GCAL---------SPFSVYR-----PPHSI---------------------------RTTTR---------NLA----LMLHC----------------------------------------------------------PVN----------------------------------------------SSQSIIDCLRQ--K-------------------------------------------------------SAAELSIT--------YP--QHPDM--IAAFA-----------------------------------------P------RV----DG--------------Y--FL----HDTPE-KL------------------------------------------LQRGEFN------HN---------------------------------------------------------------------------------------------------------------------------VN--VM------------------T-------------------GFVPNESADE-------IP-------DDF-----------------------------------NAKG---GYDVTQYNSL-----VTSWSRRFLN--SD-------HVRS------------------------------------AVTCFY-TPSESD-DQ------------------------------------------------------------------KNVQTYMQL-----KS-D------------------------------YGYIIP----HIQMATQL-NHR-------------------------------------GTNTWLYAF-------NYRSQ---NY-------PEPSWM--------G-IIHA---------SEL-YYLFG------TPLFHSEACPGDQNVTCPQIWTSYQHWDD------------- 673
674 NGYTKINEDC--------------------LYLNIYA----------P-----------KNINH-----PAELLPVMVW----I-------H---------------------------------------------------------G--------------------G----Y-----------------------------------------------------------------------------YEA-GS------GS----------AYDGRILAS-----RG----EVIVVT------V-N---YR-LG-------------ALGFLST--------FDSM---------ATG---NQALLD--QVLA----------------------------------------------L-----------------------------K--WVQKN-----------------------------IRSFG---------------------GD------------------------------------------------------PDR----V-TI--F-G--ES-----------------AG-----------------------------G-AAVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-MFSPL-------S---------------E---------------GLFHGLITQ-----------------------------------------------------------------------------------------S-GCAL---------SPFAIYR-----PPYSQ---------------------------LSNTR---------SVA----LSLGC----------------------------------------------------------PAT----------------------------------------------SSRAMIECLRT--K-------------------------------------------------------SAQEIVEV--------KPVVHYPKL--SLAFA-----------------------------------------P------RV----DG--------------Y--FL----HDVPE-NL------------------------------------------LKRGEFH------NN---------------------------------------------------------------------------------------------------------------------------IR--VM------------------T-------------------GFVDDEASIF-------IP-------SIF-----------------------------------DKSG---GYDVHFYEAL-----LDELSSGFLH--RE-------KVQS------------------------------------ALICLY-PPAINN-SQ------------------------------------------------------------------KNVETYMQL-----AS-D------------------------------YEFRFP----TIHMSADL-TSK-------------------------------------GVLTWMYQF-------DYLSA---HT-------PEPEWK--------G-VYHS---------SEL-YFVFG------APLFNSMPCPGLRNTTCPQ----------------------- 674
675 -ILEG-SEDC--------------------LYLNVYT----------P---------------ERPRTNGS--LPVMVW----F-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------WQC-GS------GI------S--SFYGPDFLL-------D---HDIVLVS------A-N---FR-LG-------------PLGFLS---------TETLDCPG-----------NNGLKD--QLEV----------------------------------------------L-----------------------------H--WVRAN-----------------------------IASFG---------------------GD------------------------------------------------------PNS----V-TV--F-G--ES-----------------AG-----------------------------G-ASVTY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-MLSEK-------S---------------R---------------GLLHRGIAQ-----------------------------------------------------------------------------------------S-GTYF-------N----PWAQP---AHKGVA---------------------------AGRAT---------KLA----QIVGC----------------------------------------------------------G----NAG-----------------------------------------EWPEKLECLRK--K-------------------------------------------------------PAEDIVASLY----DMFVWDFDPMIPFP---------------------------------------------P------VVEPEHDG--------------A--FL----TVAPRQAA----------KPHGLQLPL-MVGAT---------AEEGLL--------KTAA-L-LN---------------------------------------------------------------------------------------------------------------------------LP--QL------------------L-------------------AEFKSQFEQVLPVVLNYD---------------------------------------------------------------------------------------------------------------------------------HHDDSV-RQTIT----------------------------------QRIESFYFKSGHDYD----------------KT----NHQNLTDL-----IS-DG--W----------------FVAGIDEYLRLRMSQEDVA------------------P----------------------------------TYVYLF----------DHKGAASFTEIFKGGRNEFY--------G-ACHA---------EEL-QYLF---PIGRELFVSAVPTQKD------------------------------ 675
676 ----TSTEDC--------------------LYLNVFT----------P---------------NIDFSTIQEPLPVMFF----I-------A---------------------------------------------------------G--------------------G----R-----------------------------------------------------------------------------FEM-GS------GS------G--ELYNGTKMVN-----SS----NIVFVS------I-N---YR-LG-------------IFGMLQT--------DTIS-----------G---NLAFED--QLLA----------------------------------------------L-----------------------------K--WVQQN-----------------------------IKAFG---------------------GD------------------------------------------------------PNQ----V-TV--F-G--ES-----------------AG-----------------------------G-TSCAL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LTSPA-------S---------------A---------------GLFSKIIIE-----------------------------------------------------------------------------------------S--------------NPWSLPIKTIDEAK--------------------------------------------DLAKIFAKDLGC----------------------------------------------------------DINDN--------------------------------------------------ACLYS--K-------------------------------------------------------NQEELLLAMNISQ--------------------------------------------NHFNVLAPLLTFLPWTP------VV----DG--------------V--LI----TDQPL-AL------------------------------------------IQKGD------Y-NK---------------------------------------------------------------------------------------------------------------------------VP--II------------------V-------------------GTVRNEALV-------------------------FV-AGIALDISKIEYIGGLIDIFGLSHEI------------------------------------------------------------------------------------KIYELY-KPFINGSNF------------------------------------------------------------------M---DTLGV-----VGTD------------------------------YIFVCP----VRNAAMYLSTNS-------------------------------------DFPVYTYQF-------QH-------------VSSFNPYGNGYDYCADQ-VCHG---------LEL-PYVFGNA--GQYTFSAQEQ---------------------------------- 676
677 --RGNYTEDC--------------------LVLNVFV----------P-----------STLNLDTAIAPEDGLPVMVW----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FMT-GS------ST------I--LFYHGEPLCN-----RT----NTVIVT------V-N---YR-LG-------------AFGFLSL--------NEGD-VVL-----E-G---NQGIRD--QQLA----------------------------------------------L-----------------------------T--WVKDN-----------------------------IANFG---------------------GD------------------------------------------------------KNK----V-TI--F-G--ES-----------------AG-----------------------------A-QSVVL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LVSPT-------S---------------E---------------SLFHRAIIQ-----------------------------------------------------------------------------------------S-SPA--------------------------Y---------------------------YQFYTNTEANELTRE-----------------------------------------------------------------------------------------------------------------------------------K-------------------------------------------------------DVDDIVAAYPAVV-NFVGQRKYGVGATETFR------------------------------------------P------YI----DE--------------V--LI----PDQPL-KL------------------------------------------LETGN------W-NK---------------------------------------------------------------------------------------------------------------------------KA--II------------------I-------------------GSNTEEG-Q-------------------------------------------------------------------------------------------------------------------------------------------------------SESFQQFHDFELFKATTTYF---FGPILAPSLIREYSKLVANVSD-DYDY--I----------------K---LIEDM-----TG-D------------------------------GLFVCP----TRTLARLAYET-----TNI------------------------------PNSVFLYSN-------AY-PPN----------------A----ST------HA---------VEI-PYVFRT--VFNETADDNI----------------------------------- 677
678 ----RQSENC--------------------LYVNVFA-----P-D-TP-----------S-QN---------L-PVMVW----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FYL-GA------GS------E--PLFDGSRLAA-----QG----EVIVVT------L-N---YR-LG-------------PFGFLHL-------SSFDEA--Y-----S-D---NLGLLD--QAAA----------------------------------------------L-----------------------------K--WVRDN-----------------------------ISAFG---------------------GD------------------------------------------------------PDN----V-TV--F-G--ES-----------------AG-----------------------------G-MSIAA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LAMPA-------A---------------K---------------GLFQKAIME-----------------------------------------------------------------------------------------S-GASR---------T----MT---TEK---A---------------------------ASTAA---------AFL----QVLGI----------------------------------------------------------NESQ--------------------------------------------------LDRLH---T------V------------------------------------------------SAEDLLKA---AD-KLRKAENE------------NLF---QLLFQ----------------------------P------AL----DP--------------K--TL----PAEPE-KA------------------------------------------IAGGA------A-AD---------------------------------------------------------------------------------------------------------------------------IP--LL------------------I-------------------GTNRDEGYL------------------FF-------T--------PD--SD-VHS---------QETF----------------------NAAL-EYLL-------EQP----------------------LAKKAAD---------LYPRSL----------------------------------------------------------------------------E---SQIHM-----MT-D------------------------------LLFWRP----AVAYASAQ-SQY-------------------------------------AP-VWMYRF-DWPSDKP----------------P---YN--------K-AFHA---------LEL-PFVFG--------------NLDGLERMAKAE---------------------- 678
679 ----RQSEDC--------------------LYVNVFA-----P-D-TP-----------S-KN---------L-PVMVW----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FYL-GA------GS------E--PLYDGSKLAA-----QG----EVIVVT------L-N---YR-LG-------------PFGFLHL-------SSFNEA--Y-----S-D---NLGLLD--QAAA----------------------------------------------L-----------------------------K--WVREN-----------------------------ISAFG---------------------GD------------------------------------------------------PDN----V-TV--F-G--ES-----------------AG-----------------------------G-MSIAA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LAMPA-------A---------------K---------------GLFQKAIME-----------------------------------------------------------------------------------------S-GASR---------T----MT---KEQ---A---------------------------ASTSA---------AFL----QVLGI----------------------------------------------------------NEGQ--------------------------------------------------LDKLH---T------V------------------------------------------------SAEDLLKA---AD-QLRIAEKE------------NIF---QLFFQ----------------------------P------AL----DP--------------K--TL----PEEPE-KA------------------------------------------IAEGA------A-SG---------------------------------------------------------------------------------------------------------------------------IP--LL------------------I-------------------GTTRDEGYL------------------FF-------T--------PD--SD-VHS---------QETL----------------------DAAL-EYLL-------GKP----------------------LAEKVAD---------LYPRSL----------------------------------------------------------------------------E---SQIHM-----MT-D------------------------------LLFWRP----AVAYASAQ-SHY-------------------------------------AP-VWMYRF-DWHPKKP----------------P---YN--------K-AFHA---------LEL-PFVFG--------------NLDGLERMAKAE---------------------- 679
680 -PENMS-EDC--------------------LSLNIWS----------P---------------S---LNKEACLPVMVY----I-------H---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------FLI-GT------GE----------VYDGTALCT-----LH----GVIVVT------I-N---YR-LG-------------LLGFLFN--------EAAG---------IRG---NMGLLD--QIAA----------------------------------------------L-----------------------------K--WVQKY-----------------------------IRHFG---------------------GD------------------------------------------------------ANN----V-TV--F-G--ES-----------------AG-----------------------------A-ISIAS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPL-------A---------------T---------------GLFHRAICQ-----------------------------------------------------------------------------------------S-GTML---------YPSAAWTPTQANKYWLK---------------------------RLQAK----------------GLSGD----------------------------------------------------------HPSVVKSFLSNLDPYS---------------------------------FVESIKTSCH-------------------------------------------------------------------------------------------------------------------------------------------VI----DG--------------S--FL----PAEPK-AL------------------------------------------MTSKR------I-NP---------------------------------------------------------------------------------------------------------------------------VP--LL------------------I-------------------GFNQCEGYD----------------------------------------FMIPIVGS--EGLKSLARA----------------------REIIEFLVTKAFFRGLANSAD------------------------------------VIQLLM----------------------------------------KEYVLSLGDATEDVVMEAL-----------------------VHL-----YG-D------------------------------LLFVAP----SLLQAELQSDVS---------------------------------------PTYVYEF----------AHRL------SVSTT-PSWC--------L-SKHG---------EEI-PFVFGEPFLDRFPDGIWSEDE-------------------------------- 680
681 DKQVRGAEDC--------------------LFLNVYA-----P---TN-----------A-QK---------A-PVMVW----I-------H---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------FQM-GA------GS------D----YDLSVLAR-----EQ----GVVAVS------L-N---YR-LG-------------ALGFLAT-------PALDTAQGT-----A-G---NLGLLD--QQLA----------------------------------------------L-----------------------------K--WVRDN-----------------------------IAAFG---------------------GD------------------------------------------------------AQN----V-TV--F-G--ES-----------------AG-----------------------------G-MSICA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-LASPG-------A---------------A---------------GLFDKAIIQ-----------------------------------------------------------------------------------------S-GPCT---------APGIMQS---RAE---A---------------------------YNLGS---------RFA----AAVGC----------------------------------------------------------DPAD--------------------------------------------------AACLR---A------V-------------------------------------------------------P---AD-KLVLTRSP------------NAAFPGAVPFP----------------------------P------VY----GD--------------S--TV----PRAPA-EV------------------------------------------LRQGQ------N-A----------------------------------------------------------------------------------------------------------------------------VP--LL------------------I-------------------GTNLNEGTL------------------FA-------AFVGD----PR--RD-LNA---------AEFL------------------------GL-NAVL-------NGP----------------------NA----------------PRAL----LA-YNS---------------------------------------R---TS-GTRT----------------Q---AAAAS-----AT-D------------------------------SLFACP----SSNLARDI-SRF-------------------------------------TP-VYSYEFRDPNPPRPA-QLRPTVG------VP---SF--------G-AFHG---------SEI-VSVTG--------------TPSGLGNPSDFTP--------------------- 681
682 TQELEGSEDC--------------------LHLNVYT--------------------------PGAGEKAGQPLPVMVF----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FLF-GS------GN------G--DCYSPEYL-------LQ---EEVIVVT------L-N---YR-LG-------------ALGFLHL----------PSQGIE-------G---NAGLKD--QLAV----------------------------------------------L-----------------------------R--WVQQN-----------------------------IAAFN---------------------GD------------------------------------------------------PHN----V-TL--F-G--ES-----------------AG-----------------------------A-ASVHL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-MLSPV-------S---------------R---------------QYFHRAICQ-----------------------------------------------------------------------------------------S-GASV---------MEWVMQRDSINRTR--------------------------------------------SLA----RHI-D----------------------------------------------------------PDAKT--------------------------------------------DEQVYRTLLAA--D-------------------------------------------------------KAQLMGLMLHT---LSADEKRRGLPMPFK--------------------------------------------P------VV----EE----------GEPGPDTVV----PVHPF-VA------------------------------------------MQQRDRTGT---------------------------------------------------------------------------------------------------------------------------------MP--II------------------F-------------------GNNDREGTI-----------MMMDAIKKLDLYDNDMARMIPRTVNVA-PGSAACE--------------------------------------------------------------------------------------------QLASEV------------------------------------------------KQFYCGAQGVTK----------------ETANQLADL-----MT-D------------------------------YHFGIL----ANTCAELHARYQP------------------------------------NSPMFYYQFSYDGEL--N-----------------MYKKLLQ-LSIPG-ACHA---------DEL-SYLFLMRLANYDVKPDTEAGRVR------------------------------ 682
683 -------------------------------VFTTQM-----P-KDDE-----------S-AE----QPK--L-PVMVW----L-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FSF-GS------GN------S--FLYGPDYLVA------E----DIVLVT------L-N---YR-LG-------------PLGFLTA-------GPD-----A-----P-G---NQGLKD--QVLA----------------------------------------------L-----------------------------K--WVRDN-----------------------------IAAFG---------------------GD------------------------------------------------------PNQ----V-TI--F-G--ES-----------------AG-----------------------------A-SSVQL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LLSSQ-------A---------------K---------------GLFHRAISQ-----------------------------------------------------------------------------------------S-GSAL---------NPWSMSA-----S---S---------------------------SQRAA---------RLA----ANLGY----------------------------------------------------------VGANKTED---------------------------------------------ILDFLR---R------V------------------------------------------------PAMKLVEA---AP-TTITAEDQ-----------RNNI---GLPFV----------------------------P------VV----EGYWNQDSQEEQFYEEP--FL----TQHPS-DM------------------------------------------YHSQN------F-NS------------------------------------------------------------------------------------------------------------------D--------VA--YM------------------T-------------------GYNTHEAML------------------FI--------------------RR-LRK---------NPQL----------------------LSII--------------------------------------ENDFGR---------LVPQDL----NV-TES---------------------------------------H---DR-VTREIRSFYLGSKHVGIESVD---EMIAL-----LT-D------------------------------LMFLQG----IRRTARNH-AKF-----G-------------------------------NAPVYMYRFSFDGSLGLY-KRMLGIP------RP-------------G-VCHG---------DEL-GYLFK------FGFF--NLSLDPKSMEVQ------------------------ 683
684 LPPVSMSEDC--------------------LYLNIYA----------P-----------A-HAH---EGS--NLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LMT-GM------AS------M----YDGSLLTV-----NE----DLVVVT------I-Q---YR-LG-------------VLGFFST--------GDEH---A-----R-G---NWGYLD--QVAA----------------------------------------------L-----------------------------R--WVQQN-----------------------------IAHFG---------------------GN------------------------------------------------------PDR----V-TI--F-G--ES-----------------AG-----------------------------G-TCVST---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VVSPM-------S---------------Q---------------GLFHGAIME-----------------------------------------------------------------------------------------S-GVAL---------LPYLIAD------T--S---------------------------EMFST---------MVA----KVSGC----------------------------------------------------------EAM----------------------------------------------DSEALVHCLR---A------K------------------------------------------------SEAEILAI----N-----KVVQM---------------------VP---------------------------A------VV----DG--------------E--FL----PRHPK-EL------------------------------------------LASED------F-RP---------------------------------------------------------------------------------------------------------------------------VP--SI------------------I-------------------GVNNDEYGW-----------------------------TIPL-VMGTTQMIKELS---------RENL----------------------QAILKKTTAQL--MLPLECSD------------------------------------LLMEEY----------------------------------------------MGDI---EDPKTLQ----------------A---QFTEL-----ME-D------------------------------FMFVIP----ALQVAHFQ-CSH------A------------------------------P--VYFYEF-------QH-QITFLKD------IR-PPHV--------K-ADHA---------D-------------------------------------------------------- 684
685 LPPVSMSEDC--------------------LYLNIYT----------P-----------A-HAQ---EGS--NLPVMVW----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------LTV-GM------AS------M----YDGSVLAA-----TE----DVVVVA------I-Q---YR-LG-------------VLGFFST--------GDEH---A-----R-G---NWGFLD--QVAA----------------------------------------------L-----------------------------R--WVQQN-----------------------------IAHFG---------------------GN------------------------------------------------------PDR----V-TI--F-G--ES-----------------AG-----------------------------G-ISVSS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VVSPM-------S---------------K---------------GLFHRAIME-----------------------------------------------------------------------------------------S-GVAL---------LPGTIFS------F--S---------------------------EVVYQ---------TVA----KLSGC----------------------------------------------------------EAM----------------------------------------------DSEALVRCLR---G------K------------------------------------------------SEEEILAI----S-----KNFQM---------------------IP---------------------------G------VV----DG--------------E--FL----PKHPQ-EL------------------------------------------LASAD------F-HP---------------------------------------------------------------------------------------------------------------------------VP--SI------------------I-------------------GFNNDEYGW-----------------------------IVPK-VIGSTQTIKGIT---------RENL----------------------QAVLKDTAPQM--MLPPECSD------------------------------------LLMEEY----------------------------------------------MEDI---EDPKTLQ----------------I---QFTEM-----ME-D------------------------------FMFVIP----SLQVAYFQ-RSH------A------------------------------P--VYFYEF-------QH-QSSFLKD------VR-PPHV--------N-ADHG---------DEV-PFVFG------SFFW--GMKL----NLTE------------------------ 685
686 LPPVSTSEDC--------------------LYLNIYT----------P-----------A-HAH---EGS--NLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LVA-GM------AS------M----YDGSLLAA-----IE----DLVVVT------I-Q---YR-LG-------------VLGFFST--------GDQH---A-----R-G---NWGFLD--QVAA----------------------------------------------L-----------------------------R--WIQQN-----------------------------IAHFG---------------------GK------------------------------------------------------PDR----V-TI--F-G--ES-----------------AG-----------------------------G-TSVSS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VVSPM-------S---------------K---------------GLFHGAIME-----------------------------------------------------------------------------------------S-GVAL---------LPYLITD------T--S---------------------------EMVST---------TVA----KLSGC----------------------------------------------------------EAM----------------------------------------------DSEALVRCLR---G------K------------------------------------------------SEAEILAI----N-----KLVQM---------------------IP---------------------------A------VV----DG--------------E--FF----PRHPK-EL------------------------------------------LASED------F-HP---------------------------------------------------------------------------------------------------------------------------VP--SI------------------I-------------------GVNNDEFGW-----------------------------TIPV-VMGSAQTIKEIT---------RENL----------------------QAVLKNTTAQL--MLPPECSD------------------------------------LLMEEY----------------------------------------------MGDT---EDAQTLQ----------------I---QFTEM-----ME-D------------------------------FMFVIP----ALQVAYFQ-RSH------A------------------------------S--VYFYEF-------QH-QIASLKD------VR-PTHV--------K-ADHA---------DEI-PFVFG------YFFW--DMKL----D--------------------------- 686
687 RSPVSMSEDC--------------------LYLSIYT----------P-----------A-HTH---KDS--NLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LCW-GM------AS------T----YDGSMLAA-----IE----DVVVVT------I-Q---YR-LG-------------ILGFFST--------GDEH---A-----R-G---NWGYLD--QVAA----------------------------------------------L-----------------------------R--WVQQN-----------------------------IVHFG---------------------GN------------------------------------------------------PDR----V-TI--F-G--ES-----------------AG-----------------------------G-ISVSS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VVSPM-------S---------------Q---------------GLFHGAIME-----------------------------------------------------------------------------------------S-GVAL---------LPNLISN------T--S---------------------------EVIYT---------MVA----NLSGC----------------------------------------------------------EPV----------------------------------------------DSEALMSCLR---E------K------------------------------------------------SEEEMLAI----N-----NIVRT---------------------IS---------------------------G------VV----DG--------------K--FL----PRHPL-EL------------------------------------------LASVD------F-HP---------------------------------------------------------------------------------------------------------------------------VP--SI------------------I-------------------GINSDEYGW-----------------------------IIP--MLHPDSTMKEIN---------RETM----------------------RAVLKNTAVQM--MLPPECSD------------------------------------LLTEEY----------------------------------------------MGDT---EDSKTLQ----------------I---QFNEM-----MG-D------------------------------FIFVIP----ALQVAHFQ-RSH------A------------------------------P--VYFYEF-------QH-QSNFLKD------IR-PPHV--------K-ADHG---------DEL-PYVIG------YLFW--DMKF----VFTE------------------------ 687
688 LSSFPMSEDC--------------------LYLNIYT----------P-----------A-HAH---EGS--NLPVMVW----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------LVI-GM------AS------M----FDGSLLTV-----NE----DLVVVT------I-Q---YR-LG-------------VLGFFST--------GDQH---A-----R-G---NWGYLD--QAAA----------------------------------------------L-----------------------------R--WVQQN-----------------------------IAHFG---------------------GN------------------------------------------------------PDR----V-TI--F-G--ES-----------------AG-----------------------------G-TSVSS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VVSPM-------S---------------Q---------------GLFHGAIME-----------------------------------------------------------------------------------------S-GVAL---------LPDLISE------T--S---------------------------EMVST---------TVA----KLSGC----------------------------------------------------------EAM----------------------------------------------DSQALVRCLR---G------K------------------------------------------------SEAEILAI----N-----KVFKM---------------------IP---------------------------A------VV----DG--------------E--FF----PRHPK-EL------------------------------------------LASED------F-HP---------------------------------------------------------------------------------------------------------------------------VP--SI------------------I-------------------GVNNDEFGW-----------------------------SIPV-VMGSAQMIKGIT---------RENL----------------------QAVLKDTAVQM--MLPPECSD------------------------------------LLMEEY----------------------------------------------MGDT---EDAQTLQ----------------I---QFTEM-----MG-D------------------------------FMFVIP----ALQVAHFQ-RSH------A------------------------------P--VYFYEF-------QH-PPSYFKD------VR-PPHV--------K-ADHA---------DEI-PFVFA------SFFW--GMKL----DFTE------------------------ 688
689 LPPISMSEDC--------------------LYLNIYV----------P-----------A-HAH---EGS--NLPVMVW----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------LTV-GM------AS------M----YDGSMLAA-----TE----DVVVVA------I-Q---YR-LG-------------VLGFFST--------GDQH---A-----K-G---NWGYLD--QVAA----------------------------------------------L-----------------------------R--WVQQN-----------------------------IVHFG---------------------GN------------------------------------------------------PDR----V-TI--F-G--ES-----------------AG-----------------------------G-TSVSS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VVSPM-------S---------------Q---------------GLFHGAIME-----------------------------------------------------------------------------------------S-GVAV---------LPDLISS------S--S---------------------------EMVHR---------IVA----NLSGC----------------------------------------------------------AAV----------------------------------------------NSETLMCCLR---G------K------------------------------------------------NEAEMLAI----N-----KVFKI---------------------IP---------------------------G------VV----DG--------------E--FL----PKHPQ-EL------------------------------------------MASKD------F-HP---------------------------------------------------------------------------------------------------------------------------VP--SI------------------I-------------------GINNDEYGW-----------------------------ILPT-IMDPAQKIEEIT---------RKTL----------------------PAVLKSTALKM--MLPPECGD------------------------------------LLMEEY----------------------------------------------MGDT---EDPETLQ----------------A---QFREM-----KG-D------------------------------FMFVIP----ALQVAHFQ-RSH------A------------------------------P--VYFYEF-------QH-RPSFFKD------FR-PPYV--------K-ADHG---------DEI-FLVFG------YQFG--NIKL----PYTE------------------------ 689
690 MHPTPMSEDC--------------------LYLNIYT----------P-----------A-HAR---EGS--NLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LVL-GS------AS------M----NVASTLAA-----TE----EIVIVA------I-Q---YR-LG-------------ILGFFST--------GDEH---A-----R-G---NWGYLD--QVAA----------------------------------------------L-----------------------------C--WVQQN-----------------------------IAYFG---------------------GN------------------------------------------------------HGK----V-TI--F-G--VS-----------------AG-----------------------------G-TSVSS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VVSPM-------S---------------K---------------GLFHGAIMQ-----------------------------------------------------------------------------------------S-GVAL---------LPDLISD------T--S---------------------------EVVYK---------TVA----NLSGC----------------------------------------------------------EAS----------------------------------------------DSEALIRCLR---A------K------------------------------------------------SKQEILAI----N-----QVFKM---------------------IP---------------------------G------VV----DG--------------K--FL----PKHPQ-EL------------------------------------------LASGD------F-HP---------------------------------------------------------------------------------------------------------------------------VP--SI------------------I-------------------GVNTDECGL-----------------------------GVPM-FMGLDHIIKKIT---------RDTL----------------------PTVLKSTAAQM--MLPPECID------------------------------------LIMEEY----------------------------------------------MGDT---EDPETLQ----------------E---QFKEM-----LG-D------------------------------FMFVIP----ALEVAHFQ-RSQ------A------------------------------P--VYFYEF-------QH-LPSFIKQ------VR-PSHV--------K-ADHG---------DDI-LFVFS------SYFW--GMNF----D--------------------------- 690
691 VHPTPMSEDC--------------------LYLNIYT----------P-----------A-HAR---EGS--NLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LVL-GS------AS------M----NDASTLAA-----TE----EIVIVS------I-Q---YR-LG-------------VLGFFST--------GDQN---A-----R-G---NWGYLD--QVAA----------------------------------------------L-----------------------------R--WVQQN-----------------------------IAYFG---------------------GN------------------------------------------------------HGK----V-TI--F-G--GS-----------------AG-----------------------------G-TSVSS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VVSPM-------S---------------K---------------GLFHGAIMQ-----------------------------------------------------------------------------------------S-GVAL---------LPDLISD------K--S---------------------------EVVYK---------TVA----NLSGC----------------------------------------------------------EAP----------------------------------------------DSEALIRCLR---A------K------------------------------------------------SKQEILAI----N-----QVFKM---------------------IP---------------------------G------VV----DG--------------K--FL----PKHPQ-EL------------------------------------------LASGD------F-HP---------------------------------------------------------------------------------------------------------------------------VP--SI------------------I-------------------GINTDECGW-----------------------------GIPV-FLGLDHIIKKIT---------RETL----------------------PTVLKSTAAQM--MLPPECID------------------------------------LIMEEY----------------------------------------------MGDT---ENPETLQ----------------E---QFRHM-----LG-D------------------------------FMFVIP----ALQVAHFQ-RSQ------A------------------------------P--VYFYEF-------QH-LPSFIKQ------VR-PSHV--------K-ADHG---------DDI-LFVFG------SYLW--GMTF----DLTE------------------------ 691
692 LPPISMSEDC--------------------LYLNIYT----------P-----------T-HAQ---EGS--NLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LVV-GS------AS------M----NDVSKLAA-----TE----EIVIVA------I-Q---YR-LG-------------VLGFFST--------GDQH---A-----R-G---NWGYLD--QVAA----------------------------------------------L-----------------------------R--WVQKN-----------------------------IAYFG---------------------GN------------------------------------------------------RDR----V-TI--F-G--VS-----------------AG-----------------------------G-TSVSS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-ILSPM-------S---------------K---------------GLFHGAIMQ-----------------------------------------------------------------------------------------S-GVAL---------LPDLISD------T--S---------------------------EVVYK---------TVA----NLSGC----------------------------------------------------------EAT----------------------------------------------DSEALIHCLR---A------K------------------------------------------------SKQEILAI----N-----QVFKM---------------------IP---------------------------A------VV----DG--------------E--FL----PKHPQ-EL------------------------------------------LTSMD------F-HP---------------------------------------------------------------------------------------------------------------------------VP--SI------------------I-------------------GVNTDECGW-----------------------------GVPM-FMGLDHIIKNIT---------RETL----------------------PAVLKNTAARM--MLPPECSH------------------------------------LLVEEY----------------------------------------------MGDT---EDPETLQ----------------A---QFREM-----LG-D------------------------------FMFVIP----ALQVAHFQ-RSQ------A------------------------------P--VYFYEF-------QH-LSSFIKH------VR-PSHV--------K-ADHG---------DDV-AFVFG------SYLW--DMNL----DLTE------------------------ 692
693 LPPFPMSEDC--------------------LYLNIYA----------P-----------D-HAH---EGS--NLPVMVW----I-------H---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------LVI-GM------AS------M----YDGSMLAA-----ME----NVVVVT------I-Q---YR-LG-------------VLGFFST--------GDER---A-----R-G---NWGYLD--QVAA----------------------------------------------L-----------------------------R--WLQQN-----------------------------IAYFG---------------------GN------------------------------------------------------PDR----V-TI--F-G--TS-----------------AG-----------------------------G-TSVSS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VVSPM-------S---------------Q---------------GLFRGAIME-----------------------------------------------------------------------------------------S-GVAL---------ISSLISV------S--S---------------------------DVVYQ---------TVA----NLSGC----------------------------------------------------------EQV----------------------------------------------DSEALVNCLR---G------K------------------------------------------------SEEEIMAI----N-----KAFKI---------------------IP---------------------------G------IV----DG--------------I--FL----PRHPQ-EL------------------------------------------MASAD------F-HP---------------------------------------------------------------------------------------------------------------------------VP--SI------------------I-------------------GVNNDEYGW-----------------------------IIPS-SMSMIDSKKGMD---------RQMV----------------------QAILQRRATQM--MWPPEVSD------------------------------------LLMEEY----------------------------------------------MGDN---EDPQFLQ----------------V---QFKEM-----MK-D------------------------------FTFVIP----ALQVAQFQ-RSH------A------------------------------P--VFFYEF-------QH-RPSFFKD------SK-PSHV--------K-ADHG---------DEI-LFIFR------SFWG--GTQV----D--------------------------- 693
694 LPFTSTSEDC--------------------LYLSVYT----------P-----------A-HTH---QGS--NLPVMVW----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------LVH-GM------AS------M----YDGSALAA-----FE----DVVVVI------I-Q---YR-LG-------------VLGFFST--------GDKH---A-----A-G---NWGYLD--QVAA----------------------------------------------L-----------------------------H--WVQQN-----------------------------IAYFG---------------------GD------------------------------------------------------PGR----V-TI--F-G--ES-----------------AG-----------------------------G-TSVSS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VVSPM-------S---------------Q---------------GLFHRAIME-----------------------------------------------------------------------------------------S-GVAL---------LPNLIAS------S--S---------------------------DVVSK---------TVA----NLSAC----------------------------------------------------------GQV----------------------------------------------DSEALVHCLR---D------K------------------------------------------------SEEEILAI----N-----KAFKI---------------------IP---------------------------G------MV----DG--------------I--FL----PRHPE-EL------------------------------------------LASAD------F-QP---------------------------------------------------------------------------------------------------------------------------VP--SI------------------I-------------------GVNNDEYGW-----------------------------LLPS-GVGTLDTQREMD---------RETI----------------------KALLQKTAAVM--TLPPEFGE------------------------------------LVMEEY----------------------------------------------MGGS---EDPQTLQ----------------T---QFQEI-----ME-D------------------------------SIFVIP----ALQVAYFQ-RSR------A------------------------------P--VYFYEF-------QH-RPSLFKD------IK-PPHV--------K-ADHG---------DEV-LFVFG------TYFW--GNYI----E--------------------------- 694
695 FPSDSMSEDC--------------------LYLSIYT----------P-----------A-HSH---EGS--NLPVMVW----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------LVF-GM------AS------L----YDGSMLAA-----LE----NVVVVI------I-Q---YR-LG-------------VLGFFST--------GDKH---A-----T-G---NWGYLD--QVAA----------------------------------------------L-----------------------------R--WVQQN-----------------------------IAHFG---------------------GN------------------------------------------------------PDR----V-TI--F-G--ES-----------------AG-----------------------------G-TSVSS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VVSPI-------S---------------Q---------------GLFHGAIME-----------------------------------------------------------------------------------------S-GVAL---------LPGLIAS------S--A---------------------------DVIST---------VVA----NLSAC----------------------------------------------------------DQV----------------------------------------------DSEALVGCLR---G------K------------------------------------------------SKEEILAI----N-----KPFKM---------------------IP---------------------------G------VV----DG--------------V--FL----PRHPQ-EL------------------------------------------LASAD------F-QP---------------------------------------------------------------------------------------------------------------------------VP--SI------------------V-------------------GVNNNEFGW-----------------------------LIPK-VMRIYDTQKEMD---------REAS----------------------QAALQKMLTLL--MLPPTFGD------------------------------------LLREEY----------------------------------------------IGDN---GDPQTLQ----------------A---QFQEM-----MA-D------------------------------SMFVIP----ALQVAHFQ-CSR------A------------------------------P--VYFYEF-------QH-QPSWLKN------IR-PPHM--------K-ADHG---------DEL-PFVFR------SFFG--GNYI----KFTEEE---------------------- 695
696 LPSTSMSEDC--------------------LYLNIHT----------P-----------A-YSH---EGS--NLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LVL-GM------AS------M----YDGSALAA-----FG----DVVVVV------I-Q---YR-LG-------------LLGFFST--------GDKH---A-----T-G---NWGYLD--QVAA----------------------------------------------L-----------------------------R--WVQQN-----------------------------IAYFG---------------------GD------------------------------------------------------PGR----V-TI--F-G--ES-----------------AG-----------------------------G-ISVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VISPM-------S---------------Q---------------GLFHGAIME-----------------------------------------------------------------------------------------S-GVAL---------LPGLTIN------S--S---------------------------DKVAK---------VVA----NLSAC----------------------------------------------------------GQV----------------------------------------------DSEALVDCLR---H------K------------------------------------------------NEEEVLAI----N-----KLVKI---------------------IP---------------------------G------VV----DG--------------I--FL----PKHPL-EL------------------------------------------LASDD------F-QP---------------------------------------------------------------------------------------------------------------------------VP--SI------------------I-------------------GVNNDEYGW-----------------------------IIPL-SVNNSDTRREIS---------RESV----------------------RNALQELSTMT--TMPPEFGE------------------------------------LLMEEY----------------------------------------------IEDS---EDHQNLQ----------------N---QLHEI-----MG-D------------------------------YLFVIP----ALQVAMFH-RSH------A------------------------------P--VYFYEF-------QH-QSSFFKD------VR-PSSV--------R-ADHG---------DEV-LFLFR------N------EQI----Q--------------------------- 696
697 LPFTSMSEDC--------------------LYLSIYT----------P-----------A-HAR---EGS--NLPVLVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FTV-GM------AS------M----YDGSALAA-----FE----DLVVVI------I-Q---YR-LG-------------VLGFFST--------GDKH---A-----T-G---NWGYLD--QVAA----------------------------------------------L-----------------------------R--WVQQN-----------------------------IAYFG---------------------GD------------------------------------------------------PGR----V-TI--S-G--ES-----------------AG-----------------------------G-TSVSS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VVSPM-------S---------------K---------------GLFHGAIME-----------------------------------------------------------------------------------------S-GVAL---------LPSLIDS------S--S---------------------------DVVST---------MVA----NMSAC----------------------------------------------------------GQI----------------------------------------------DSEALVDCLR---G------K------------------------------------------------SEEEILAI----N-----KPFRI---------------------VP---------------------------G------VV----DG--------------T--FL----PRHPH-EL------------------------------------------LASAD------F-QP---------------------------------------------------------------------------------------------------------------------------VP--SI------------------I-------------------GVNNDEYGW-----------------------------LIPS-------------------------------------------------------------VLPPQSVD------------------------------------ILMEEY----------------------------------------------LGDS---ADPQTLQ----------------V---QFHEM-----MG-D------------------------------YIFVIP----ALQVASFQ-RVH------A------------------------------P--VYFYEF-------QH-RPSFFKD------TK-PPHV--------R-ADHG---------DEM-FFVFG------TAFW--KGYV----EVTE------------------------ 697
698 LPFTSMSEDC--------------------LYLSIYT----------P-----------A-HAR---EGS--NLPVLVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FTV-GM------AS------M----YDGSALAA-----FE----DLVVVI------I-Q---YR-LG-------------VLGFFST--------GDKH---A-----T-G---NWGYLD--QVAA----------------------------------------------L-----------------------------R--WVQQN-----------------------------IAYFG---------------------GD------------------------------------------------------PGR----V-TI--S-G--ES-----------------AG-----------------------------G-TSVSS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VVSPM-------S---------------K---------------GLFHGAIME-----------------------------------------------------------------------------------------S-GVAL---------LPSLIDS------S--S---------------------------DVVST---------MVA----NMSAC----------------------------------------------------------GQI----------------------------------------------DSEALVDCLR---G------K------------------------------------------------SEEEILAI----N-----KPFRI---------------------VP---------------------------G------VV----DG--------------T--FL----PRHPH-EL------------------------------------------LASAD------F-QP---------------------------------------------------------------------------------------------------------------------------VP--SI------------------I-------------------GVNNDEYGW-----------------------------LIPS-GLDTSDTQK--D---------RETV----------------------KAVLRNMLAML--VLPPQSVD------------------------------------ILMEEY----------------------------------------------LGDS---ADPQTLQ----------------V---QFHEM-----MG-D------------------------------YIFVIP----ALQVASFQ-RVH------A------------------------------P--VYFYEF-------QH-RPSFFKD------TK-PPHV--------R-ADHG---------DEM-FFVFG------TAFW--KGYV----E--------------------------- 698
699 LPLTSMSEDC--------------------LYLSIYT----------P-----------A-HAS---EGS--NLPVSVW----I-------H---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------LMI-GM------AS------M----YDGSALVA-----FE----DLVVVI------I-Q---YR-LG-------------VLGFFST--------GDKH---A-----T-G---NWGYLD--QVAA----------------------------------------------L-----------------------------R--WIQQN-----------------------------IAYFG---------------------GD------------------------------------------------------PGC----V-TI--F-G--GS-----------------AG-----------------------------G-ISVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VVSPM-------S---------------Q---------------GLFHRAIME-----------------------------------------------------------------------------------------S-GVAL---------LPGLTVS------S--S---------------------------DEVTT---------RVA----KLSGC----------------------------------------------------------GQV----------------------------------------------DSEALVGCLR---S------K------------------------------------------------SEEEILAI----S-----KHFKF---------------------FP---------------------------A------VV----DG--------------T--FL----PRHPQ-EL------------------------------------------LAFAD------F-QP---------------------------------------------------------------------------------------------------------------------------VP--SI------------------I-------------------GVNNNEFGW-----------------------------LLPL-VHGLLEKMGQMS---------PEDI----------------------LAILRHYLANL--DVPPELMP------------------------------------SITDEY----------------------------------------------LGSS---SDAEARR----------------D---DFQEL-----LA-D------------------------------IIMNLP----AL---NFS-RSFXGRDPGS------------------------------PPFFFFYEF-------QH-XPSSFVK------IK-PAWV--------R-ADHG---------AEV-AFIFGGHFLMDESSL--QAFP----EATEEE---------------------- 699
700 LPLTSMSEDC--------------------LYLSIYT----------P-----------A-HAS---EGS--NLPVSVW----I-------H---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------LMI-GM------AS------M----YDGSALVA-----FE----DLVVVI------I-Q---YR-LG-------------VLGFFST--------GDKH---A-----T-G---NWGYLD--QVAA----------------------------------------------L-----------------------------R--WIQQN-----------------------------IAYFG---------------------GD------------------------------------------------------PGC----V-TI--F-G--GS-----------------AG-----------------------------G-ISVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VVSPM-------S---------------Q---------------GLFHRAIME-----------------------------------------------------------------------------------------S-GVAL---------LPGLTVS------S--S---------------------------DEVTTVSIPSCEKPEVA----KLSGC----------------------------------------------------------GQV----------------------------------------------DSEALVGCLR---S------K------------------------------------------------SEEEILAI----S-----KHFKF---------------------FP---------------------------A------VV----DG--------------T--FL----PRHPQ-EL------------------------------------------LAFAD------F-QP---------------------------------------------------------------------------------------------------------------------------VP--SI------------------I-------------------GVNNNEFGW-----------------------------LLPL-TLNISDPKKEMD---------KEMV----------------------KATLQQMSSLV--ALPPEAGD------------------------------------LLIEEY----------------------------------------------IEDS---ADPQTIK----------------A---QFHEM-----ME-D------------------------------TIFVIP----ALQVANFQ-RSH------A------------------------------P--VYFYEF-------QH-QPSFFKD------IK-PPHV--------R-ADHG---------DEL-LFVFG------TISW--RGYV----KVTEEE---------------------- 700
701 ----------------------------------------------------------------------------MTW----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------LVM-SM------AS------I----RDGSMLAA-----IE----DVVVIN------I-Q---YH-LG-------------ILGFFSS--------GDEQ---A-----R-G---NWGYLV--QVAV----------------------------------------------L-----------------------------H--WVQQN-----------------------------IANFG---------------------GN------------------------------------------------------PDR----V-TI--F-G--GS-----------------AG-----------------------------G-TSVSS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-IVSPM-------S---------------Q---------------GLFHGAIME-----------------------------------------------------------------------------------------S-GVAL---------LPGLISN------T--P---------------------------EVVYI---------TVA----TLSGC----------------------------------------------------------EAM----------------------------------------------DSETLVQCLR---N------K------------------------------------------------SEEEILAI----N-----KVFTM---------------------IP---------------------------A------VV----DG--------------E--FL----PNHPQ-QL------------------------------------------LTPVD------F-HP---------------------------------------------------------------------------------------------------------------------------VP--SI------------------I-------------------GVNNDEYGW-----------------------------LFPM-IVGSDQTIKEIT---------RENL----------------------QAVLNNITTQM--MLPPECSD------------------------------------LLMEEY----------------------------------------------IGDI---EDAQTLQ----------------A---QFREM-----MG-D------------------------------FMFIIP----ALQVAHFQ-SAH------A------------------------------S--VYFYEF-------HL-EANYLKN------VR-PPHV--------K-ADHG---------DEV-PFVFG------NSFW--GMKF----DLT------------------------- 701
702 MPHFSMSEDC--------------------LYLNIYV----------P-----------A-HAN---ESS--NLPVMVW----L-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------LVM-GM------AS------M----YDGSRLAA-----TE----DVVVVA------T-Q---YR-LG-------------ILGFYST--------GDEY---A-----R-G---NWGFLD--QTAS----------------------------------------------L-----------------------------R--WVQQN-----------------------------IANFG---------------------GN------------------------------------------------------PDS----V-TL--F-G--QS-----------------AG-----------------------------G-TSVSF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VVSPM-------S---------------Q---------------GLFHRAIME-----------------------------------------------------------------------------------------S-GVAL---------LPLFISN------S--S---------------------------ETVFT---------TVA----NLSDC----------------------------------------------------------ETS----------------------------------------------NSEALVHCLR---G------K------------------------------------------------SEAEILAI----N-----KAFRI---------------------MP---------------------------V------VV----DG--------------K--FL----PRHPK-EL------------------------------------------LASAD------F-HP---------------------------------------------------------------------------------------------------------------------------VP--SI------------------I-------------------GVNNDEFGW-----------------------------ILP--------------------------------------------------TVRSRSNLLC--MLPPECGA------------------------------------LLIEEY----------------------------------------------IGDT---KDPRTLQ----------------M---QFREM-----IG-D------------------------------FTIIIP----ALQVARFQ-RSH------A------------------------------P--VYFYEF-------QH-GSRFLKN------FR-PRHV--------K-ADHG---------DEL-FLIFG------SFFW--GTKF----DLTE------------------------ 702
703 PPNVSASEDC--------------------LYLNVFT----------P---------------D---TEA--KLPVLVS----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LIA-GS------AS------M----YDTPALSA-----FE----NVVLVV------L-Q---YR-LG-------------IPGFFST--------GSKE---A-----P-G---NWGLLD--QVAA----------------------------------------------L-----------------------------R--WVQEN-----------------------------IEAFG---------------------GD------------------------------------------------------PTS----V-TI--M-G--ES-----------------AG-----------------------------G-FSVGV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-VLSPL-------S---------------R---------------GLFHRAISE-----------------------------------------------------------------------------------------S-GVAL---------LNILAVK------D--L---------------------------RAMVQ---------TVA----NVSGC----------------------------------------------------------ENS----------------------------------------------SPAALVRCLR---S------K------------------------------------------------TEEELAAL----N-IQLCQVFGS---------------------AL---------------------------A------VV----DG--------------K--LL----PKAPE-EL------------------------------------------LAAKE------F-RK---------------------------------------------------------------------------------------------------------------------------VP--YL------------------I-------------------GINNHEYGW-----------------------------TLPQ-SGLFVSITEVMD---------RQAV----------------------TAAFQESAPVL--NIPVEATQ------------------------------------RALKEY----------------------------------------------VGET---EDPRELR----------------A---QFLDY-----MG-D------------------------------VMFLLP----SVRTARAH-RDS-----GA------------------------------P--VYFYQF-------QH-RPSIFRD------TR-PVYV--------K-ADHV---------DQV-IFVSG------TPLL--RSKDSPLGEYTEEE---------------------- 703
704 IPNVSASEDC--------------------LYLNIFT----------P---------------N---TEA--KLPVLVS----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LIV-GF------AS------M----YDAPALSA-----FE----NVVLVT------L-Q---YR-LG-------------IPGFFST--------GSKE---A-----P-G---NWGLLD--QVAA----------------------------------------------L-----------------------------R--WVQEN-----------------------------IEAFG---------------------GD------------------------------------------------------PTS----V-TI--M-G--VS-----------------AG-----------------------------G-FSVGV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-VLSPL-------S---------------R---------------GLFHRAISD-----------------------------------------------------------------------------------------S-GVAL---------LDILAAK------N--P---------------------------GAMVQ---------TVA----NVSGC----------------------------------------------------------ENS----------------------------------------------SPAALVRCLR---S------K------------------------------------------------TEEELAVL----N-IQLCQIFGM---------------------AL---------------------------A------VV----DG--------------E--FL----PKAPE-KL------------------------------------------LAAKE------F-SD---------------------------------------------------------------------------------------------------------------------------VP--YL------------------I-------------------GITNHEYGW-----------------------------ALPQ-SGLFVSITEVMD---------RQAV----------------------TAAFQESAPVL--NLPVEATQ------------------------------------RALKEY----------------------------------------------VGET---EDPRELR----------------A---QFLDY-----MG-D------------------------------VMFLLP----AVRAAIAH-RDS-----GA------------------------------P--VYFYQF-------QH-PPSIARD------IR-PAYV--------K-ADHA---------DQV-AFVLG------TPLL--RSKDSPLGEYTEEE---------------------- 704
705 PPNVSASEDC--------------------LYLNVFT----------L---------------D---TEA--KLPVLVS----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LIA-GS------AS------M----YDVPALSA-----FE----NVVLVV------L-Q---YR-LG-------------IPGFFST--------GSKE---A-----P-G---NWGLLD--QVAA----------------------------------------------L-----------------------------R--WVQEN-----------------------------IEAFG---------------------GD------------------------------------------------------PTS----V-TI--M-G--AS-----------------AG-----------------------------G-FSVGV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-ILSPL-------S---------------R---------------GLFHRAISE-----------------------------------------------------------------------------------------S-GVAL---------LDILAVK------N--P---------------------------GAMVQ---------TVA----NVSDC----------------------------------------------------------ENS----------------------------------------------SPAALVRCLR---S------K------------------------------------------------TEEELAAL----N-IQLCQIFGM---------------------AL---------------------------A------VV----DG--------------E--FL----PKAPE-KL------------------------------------------LAAKE------F-SN---------------------------------------------------------------------------------------------------------------------------VP--YL------------------I-------------------GITNHEYGW-----------------------------AFPR-SGILLSTPEVMD---------RQAV----------------------TAAFQESAPVL--NLPVEATQ------------------------------------RAMEEY----------------------------------------------LGET---EDPNELR----------------A---QFLDY-----MG-D------------------------------VIFLLP----AVRAARAH-RDS-----GA------------------------------P--VYFYEF-------QH-PPSIFRD------TR-PAYV--------K-ADHG---------DQV-TFVLG------TPLL--RSKDSPLGEYTEEE---------------------- 705
706 PPNVSASEDC--------------------LYLNVFT----------P---------------D---TEA--KLPVLVW----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------LLV-GS------AS------L----YDAPALSA-----FE----NVVVVV------L-Q---YR-LG-------------IPGFFST--------GSKE---A-----P-G---NWGLLD--QVAA----------------------------------------------L-----------------------------R--WVQEN-----------------------------IEAFG---------------------GD------------------------------------------------------PTS----V-TI--M-G--ES-----------------AG-----------------------------G-FSVGV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-ILSPL-------S---------------K---------------GLFHRAISE-----------------------------------------------------------------------------------------S-GVSL---------LSGIFVK------S--P---------------------------GDMVQ---------TVA----NVSGC----------------------------------------------------------ENS----------------------------------------------SPAALVRCLR---S------K------------------------------------------------TEEELAAL----N-IQLCQVLGM---------------------VP---------------------------A------VV----DG--------------E--FL----PKAPE-EM------------------------------------------LAEKE------F-SN---------------------------------------------------------------------------------------------------------------------------VP--YV------------------I-------------------GMNNQEYGW-----------------------------VIAQ-SPILPSLTEGMD---------RQAV----------------------AAAFQESAPVL--KLRLEVTQ------------------------------------RALEEY----------------------------------------------LGET---EDPQELR----------------A---QFQDF-----MG-D------------------------------VMFLLP----SVRAARAH-RDS-----GA------------------------------P--VYFYEF-------QH-RPSIFRD------TK-PAFV--------K-ADHG---------DEV-AFVLG------TPFL--SSKDSPLGEYTEEE---------------------- 706
707 LPKLPISEDC--------------------LYLNVFT----------P---------------D---TEA--KLPVLVW----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------LIM-GC------AY------F----YNAPGLSA-----LE----NVVVVV------L-Q---YR-LG-------------IPGFFST--------GSKE---A-----P-G---NWGLLD--QVAA----------------------------------------------L-----------------------------R--WVQEN-----------------------------IEAFG---------------------GD------------------------------------------------------PTL----V-TI--M-G--ES-----------------AG-----------------------------G-FSVGV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-TLSPL-------S---------------R---------------GLFHRAISE-----------------------------------------------------------------------------------------S-GVAL---------VPSLFEK------S--P---------------------------GDMIQ---------TVA----NVSGC----------------------------------------------------------ENS----------------------------------------------SPSALVRCLR---S------K------------------------------------------------TEEELAAL----N-IQLCQVLGV---------------------IP---------------------------A------VV----DG--------------E--FL----PKAPG-EL------------------------------------------LAAKE------F-SD---------------------------------------------------------------------------------------------------------------------------VP--YL------------------I-------------------GINNHEYGW-----------------------------ILPQ-SGTFRSIMEGMD---------RQVV----------------------TAAFQQSAPIL--KIPVEATQ------------------------------------RALEEY----------------------------------------------VGET---EDPQELR----------------A---QFQDF-----MG-D------------------------------VIFGLP----SVRAARAH-RDS-----GA------------------------------P--VYFYEF-------QH-RPSIFRD------IR-PAYV--------K-ADHG---------DEV-PFVLG------ALFS--SNKDSPFGEYTEEE---------------------- 707
708 SIPLTFSEDC--------------------LYLNIYT----------P-----------V-DLR---KKN--RLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LMV-GG------AS------T----YSGLVLSA-----HE----NVVVVT------I-Q---YR-LG-------------IWGYFST--------GDEH---S-----R-G---NWGLLD--QVAA----------------------------------------------L-----------------------------R--WVQEN-----------------------------IANFG---------------------GN------------------------------------------------------PGS----V-TI--F-G--ES-----------------AG-----------------------------G-ISVSI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPL-------A---------------K---------------NLFHRAISE-----------------------------------------------------------------------------------------S-GVAL---------ITALVKK------D--M---------------------------KDAAQ---------QIA----FFAGC----------------------------------------------------------KNT----------------------------------------------TSAVTVRCLR---Q------K------------------------------------------------TEEELLEI----S-RKM-KFFTI---------DLYGDSRENHAFLP---------------------------I------VV----DG--------------V--LL----PKMPE-EI------------------------------------------LAEKK------F-NF---------------------------------------------------------------------------------------------------------------------------VP--YI------------------I-------------------GINKHEFGC-----------------------------LLPK-LMGYPLSEGKLD---------QKTA----------------------MSLLWKSCPII--GIPEELIP------------------------------------LAAEKY----------------------------------------------LEGT---DDPVKKK----------------D---LFLEV-----LG-D------------------------------AMFGVP----SVTVARYH-RDA-----GA------------------------------P--TYMYEF-------QY-HPSFSSD------MK-PKTL--------I-GDHG---------DEL-YSVFG------APFL--KG------GASEEE---------------------- 708
709 NIPLKFSEDC--------------------LYLNIYT----------P-----------A-DLT---KNS--RLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LVV-GG------AS------T----YDGLALSA-----HE----NVVVVT------I-Q---YR-LG-------------IWGFFST--------GDEH---G-----R-G---NWGHLD--QLAA----------------------------------------------L-----------------------------R--WVQEN-----------------------------IANFG---------------------GN------------------------------------------------------PGS----V-TI--F-G--ES-----------------AG-----------------------------G-ESVSV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPL-------A---------------K---------------NLFHRAISE-----------------------------------------------------------------------------------------S-GVAL---------TAALVKK------D--M---------------------------KDTAQ---------QIA----VFAGC----------------------------------------------------------KST----------------------------------------------TSAVLVHCLR---Q------K------------------------------------------------TEDELLEV----S-LKL-KFFTL---------DLFGDPRESYPFLP---------------------------T------VV----DG--------------V--LL----PKMPQ-EI------------------------------------------LAEKK------F-NS---------------------------------------------------------------------------------------------------------------------------VP--YI------------------I-------------------GINKQEFGW-----------------------------LLPM-MMGYPLSEDKLD---------QKTA----------------------SSLLWKSYPIA--NIPEELTP------------------------------------LASEKY----------------------------------------------LGGT---DDPVKKK----------------A---LFLDM-----LG-D------------------------------VVFGVP----SVTVARHH-RDA-----GA------------------------------P--TYMYEF-------QY-HPSFSSD------MK-PQTV--------V-GDHG---------DEL-FSVFG------APFL--KG------GASEEE---------------------- 709
710 NIPLKFSEDC--------------------LYLNIYT----------P-----------A-DLT---KNS--RLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LVV-GG------AS------T----YDGLALSA-----HE----NVVVVT------I-Q---YR-LG-------------IWGFFST--------GDEH---G-----R-G---NWGHLD--QLAA----------------------------------------------L-----------------------------R--WVQEN-----------------------------IANFG---------------------GN------------------------------------------------------PGS----V-TI--F-G--ES-----------------AG-----------------------------G-ESVSV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPL-------A---------------K---------------NLFHRAISE-----------------------------------------------------------------------------------------S-GVAL---------TAALVKK------D--M---------------------------KDTAQ---------QIA----VFAGC----------------------------------------------------------KST----------------------------------------------TSAVLVHCLR---Q------K------------------------------------------------TEDELLEV----S-LKL-KFFTL---------DLLGDPRESYPFLP---------------------------T------VV----DG--------------V--LL----PKMPQ-EI------------------------------------------LAEKK------F-NS---------------------------------------------------------------------------------------------------------------------------VP--YI------------------I-------------------GINKQEFGW-----------------------------LLPM-MMGYPLSEDKLD---------QKTA----------------------SSLLWKSYPIA--NIPEELTP------------------------------------LASEKY----------------------------------------------LGGT---DDPVKKK----------------A---LFLDM-----LG-D------------------------------VVFGVP----SVTVARHH-RDA-----GA------------------------------P--TYMYEF-------QY-HPSFSSD------MK-PQTV--------V-GDHG---------DEL-FSVFG------APFL--KG------GASEEE---------------------- 710
711 KIALKFSEDC--------------------LYLNIYT----------P-----------A-DLT---KKS--RLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LVV-GG------AS------T----YDGLPLSA-----YE----NVVVVT------I-Q---YR-LG-------------IWGFFST--------GDEH---S-----P-G---NWGHLD--QVAA----------------------------------------------L-----------------------------K--WVQEN-----------------------------IANFG---------------------GN------------------------------------------------------PGS----V-TI--F-G--ES-----------------AG-----------------------------G-ESVSV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-MLSPL-------A---------------K---------------NLFHRAISE-----------------------------------------------------------------------------------------S-GVAL---------TTAVCKK------D--S---------------------------KAAAQ---------KIA----VFSGC----------------------------------------------------------KTT----------------------------------------------TSAVIVHCLR---Q------K------------------------------------------------TEDELLET----S-LKM-KFFTL---------DFHGDPRESYPFLP---------------------------T------VV----DG--------------V--LL----PKMPE-EI------------------------------------------LAEKK------F-NT---------------------------------------------------------------------------------------------------------------------------VP--YI------------------V-------------------GINKQEFGW-----------------------------FLPT-ILGYPLSEGKLD---------QKKA----------------------TSLLWKSYPIV--NIPEELTP------------------------------------VAIEKY----------------------------------------------LGGT---NDPVKKK----------------D---LFLDL-----MA-D------------------------------VVFGVP----TVTVARYH-RDA-----GA------------------------------P--TYVYEF-------QH-YPSFSSD------RR-PKTV--------I-GDHM---------DEL-FPLFG------APFL--KG------GASEEE---------------------- 711
712 KIAFQFSEDC--------------------LYLNIYT----------P-----------A-DLT---KKS--RLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LMV-GR------AS------D----YDGLALSA-----YE----NVVVVT------I-Q---YR-LG-------------IWGFFST--------GDEH---S-----P-G---NWGHLD--QVAA----------------------------------------------L-----------------------------R--WVQEN-----------------------------IANFG---------------------GD------------------------------------------------------PSS----V-TI--F-G--ES-----------------AG-----------------------------G-ESVSV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPL-------A---------------K---------------NLFHRAISE-----------------------------------------------------------------------------------------S-GVAL---------TTCLVKK------D--S---------------------------KAEAQ---------QIA----ILAGC----------------------------------------------------------KTT----------------------------------------------TSAVIVDCLR---Q------K------------------------------------------------TEDELLET----S-LKM-KFFTL---------DFHGDPRESHPFLP---------------------------T------VV----DG--------------V--LL----PKMPE-EI------------------------------------------LAEKT------F-NT---------------------------------------------------------------------------------------------------------------------------VP--YI------------------V-------------------GFNKQEFGW-----------------------------ILPTQLMGYPLSEGKLD---------QKTA----------------------TSLLWKSYPIV--NIPEELTP------------------------------------AATEKY----------------------------------------------LGGT---DDPVKKK----------------D---LFLDL-----IG-D------------------------------VMFGVP----SVTVARLH-RDA-----GA------------------------------P--TYMYEF-------QY-RPSFSSD------MK-PKTV--------I-GDHG---------DDV-YSVFG------VPLI--KE------GASEEE---------------------- 712
713 NIPLKLSEDC--------------------LYLNIYT----------P-----------A-DLT---KKN--RLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LMV-GA------AS------T----YDGLALAA-----HE----NVVVVT------I-Q---YR-LG-------------IWGFFST--------GDEH---S-----R-G---NWGHLD--QVAA----------------------------------------------L-----------------------------R--WVQDN-----------------------------IASFG---------------------GN------------------------------------------------------PGS----V-TI--F-G--ES-----------------AG-----------------------------G-ESVSV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPL-------A---------------K---------------NLFHRAISE-----------------------------------------------------------------------------------------S-GVAL---------TSVLVKK-----GD--V---------------------------KPLAE---------QIA----ITAGC----------------------------------------------------------KTT----------------------------------------------TSAVMVHCLR---Q------K------------------------------------------------TEEELLET----T-LKM-KFLSL---------DLQGDPRESQPLLG---------------------------T------VI----DG--------------M--LL----LKTPE-EL------------------------------------------QAERN------F-HT---------------------------------------------------------------------------------------------------------------------------VP--YM------------------V-------------------GINKQEFGW-----------------------------LIPMQLMSYPLSEGQLD---------QKTA----------------------MSLLWKSYPLV--CIAKELIP------------------------------------EATEKY----------------------------------------------LGGT---DDTVKKK----------------D---LFLDL-----IA-D------------------------------VMFGVP----SVIVARNH-RDA-----GA------------------------------P--TYMYEF-------QY-RPSFSSD------MK-PKTV--------I-GDHG---------DEL-FSVFG------APFL--KE------GASEEE---------------------- 713
714 NISVQISEDC--------------------LYLNIYT----------P-----------A-DLT---KKS--RLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LMI-GG------AS------T----YDGLALSA-----HE----NVVVVT------I-Q---YR-LG-------------IWGFFST--------GDEH---S-----P-G---NWGHLD--QVAA----------------------------------------------L-----------------------------R--WVQEN-----------------------------IANFG---------------------GD------------------------------------------------------PGS----V-TI--F-G--ES-----------------AG-----------------------------G-ESVSV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPL-------A---------------K---------------NLFHRAISE-----------------------------------------------------------------------------------------S-GVAF---------TAGLVQK------D--S---------------------------KAAAQ---------QIA----VFAGC----------------------------------------------------------KTA----------------------------------------------TSAVIVHCLR---Q------K------------------------------------------------TEDELLET----S-VKM-KFLSL---------DFRGDSRESHPFLP---------------------------A------VV----DG--------------V--LL----PKMPE-EI------------------------------------------LAEKT------F-NT---------------------------------------------------------------------------------------------------------------------------VP--YI------------------I-------------------GINKQEFGW-----------------------------VIPM-MMGYPLSEGKLD---------QKTA----------------------TSLLQKSCPIL--NIPEEVTP------------------------------------VATEKY----------------------------------------------LGGT---EDPVKKK----------------D---LFLDL-----IG-D------------------------------VMFGVP----SVTVARLH-RDA-----GA------------------------------S--TFMYEF-------QY-RPSFSSV------MK-PKTV--------I-GDHG---------DEI-FSVFG------APFL--KE------GASEEE---------------------- 714
715 NIPVQFSEDC--------------------LYLNIYT----------P-----------A-DLT---KKS--RLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LMV-GG------AS------T----YDGLALSA-----HE----NVVVVT------I-Q---YR-LG-------------IWGFLST--------GDEH---S-----P-G---NWGHLD--QVAA----------------------------------------------L-----------------------------H--WVQDN-----------------------------IANFG---------------------GD------------------------------------------------------PGS----V-TI--F-G--ES-----------------AG-----------------------------G-ESVSV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPL-------A---------------K---------------NLFHRAISE-----------------------------------------------------------------------------------------S-GVAF---------TAGLVQK------D--S---------------------------KAAAQ---------QIA----VFAGC----------------------------------------------------------KST----------------------------------------------TSAVIVHCLR---Q------K------------------------------------------------TDDELLEL----S-LKM-KFLSL---------DLLGEPRESHPLLP---------------------------T------VV----DG--------------V--LL----PKMPE-EI------------------------------------------LAEKT------F-NT---------------------------------------------------------------------------------------------------------------------------VP--YI------------------V-------------------GINKQEFGW-----------------------------IIPT-MMGYPLSEGKMD---------QRTA----------------------TSLLQNSSTLL--NIPEELTP------------------------------------VAIEKY----------------------------------------------LGGT---DDPVKKK----------------D---LFLDL-----MG-D------------------------------VMFGVP----SVTVARLH-RDA-----GA------------------------------S--TFMYEF-------QY-RPSFSSA------MR-PKTV--------I-GDHG---------DEI-FSVFG------APFL--KE------GASEEE---------------------- 715
716 NISVQFSEDC--------------------LYLNIYT----------P-----------A-DLT---KES--RLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LVL-GG------AS------T----YDGRVLSA-----HE----NVVVVT------I-Q---YR-LG-------------IWGFLST--------GDEH---S-----R-G---NWGHLD--QLAA----------------------------------------------L-----------------------------R--WVQEN-----------------------------IANFG---------------------GD------------------------------------------------------PGS----V-TI--F-G--QS-----------------AG-----------------------------G-ASVSV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPL-------A---------------K---------------DLFHRAISE-----------------------------------------------------------------------------------------S-GVAL---------TAVVADD------Y--M---------------------------RAAVQ---------QFA----NFSGC----------------------------------------------------------NTT----------------------------------------------TSAVIVDCLR---Q------K------------------------------------------------SEKELLEA----S-LKM-KFLML---------DFTGDSRESYPFLA---------------------------T------VV----DG--------------V--LL----PKMPK-EI------------------------------------------LAEKT------F-NT---------------------------------------------------------------------------------------------------------------------------VP--YV------------------V-------------------GLNKHEFGW-----------------------------ILPT-VMGFPLSEGKLD---------QKTA----------------------TSLLQKANPIL--HIPEELTP------------------------------------VAVEKY----------------------------------------------LGGT---DNPVKKK----------------D---LFLDL-----MG-D------------------------------LMFGVP----IITLARLH-RDA-----GA------------------------------S--TYVYEF-------QH-RPSFSSV------MR-PKTV--------M-WDHG---------DEL-FSLFG------APFL--KE------GASEEE---------------------- 716
717 NIPLQFSEDC--------------------LYLNIYT----------P-----------A-DLT---KNS--RLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LVV-GG------AS------T----YDGLALSA-----HE----NVVVVT------I-Q---YR-LG-------------IWGFFST--------GDEH---S-----R-G---NWGHLD--QVAA----------------------------------------------L-----------------------------R--WVQDN-----------------------------IANFG---------------------GN------------------------------------------------------PGS----V-TI--F-G--ES-----------------AG-----------------------------G-FSVSV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPL-------A---------------K---------------NLFHRAISE-----------------------------------------------------------------------------------------S-GVSL---------TAALITT------D--V---------------------------KPIAG---------LVA----TLSGC----------------------------------------------------------KTT----------------------------------------------TSAVMVHCLR---Q------K------------------------------------------------TEDELLET----S-LKL-NLFKL---------DLLGNPKESYPFLP---------------------------T------VI----DG--------------V--VL----PKAPE-EI------------------------------------------LAEKS------F-ST---------------------------------------------------------------------------------------------------------------------------VP--YI------------------V-------------------GINKQEFGW-----------------------------IIPT-LMGYPLAEGKLD---------QKTA----------------------NSLLWKSYPTL--KISENMIP------------------------------------VVAEKY----------------------------------------------LGGT---DDLTKKK----------------D---LFQDL-----MA-D------------------------------VVFGVP----SVIVSRSH-RDA-----GA------------------------------S--TYMYEF-------EY-RPSFVSR------HEDPKAV--------I-GDHG---------DEI-FSVFG------SPFL--KD------GASEEE---------------------- 717
718 NIPLQFSEDC--------------------LYLNIYT----------P-----------A-DLT---KNS--RLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LVV-GG------AS------T----YDGLALSA-----HE----NVVVVT------I-Q---YR-LG-------------IWGFFST--------GDEH---S-----R-G---NWGHLD--QVAA----------------------------------------------L-----------------------------R--WVQDN-----------------------------IANFG---------------------GN------------------------------------------------------PGS----V-TI--F-G--ES-----------------AG-----------------------------G-FSVSV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPL-------A---------------K---------------NLFHRAISE-----------------------------------------------------------------------------------------S-GVSL---------TAALITT------D--V---------------------------KPIAG---------LVA----TLSGC----------------------------------------------------------KTT----------------------------------------------TSAVMVHCLR---Q------K------------------------------------------------TEDELLET----S-LKL-NLFKL---------DLLGNPKESYPFLP---------------------------T------VI----DG--------------V--VL----PKAPE-EI------------------------------------------LAEKS------F-ST---------------------------------------------------------------------------------------------------------------------------VP--YI------------------V-------------------GINKQEFGW-----------------------------IIPT-LMGYPLAEGKLD---------QKTA----------------------NSLLWKSYPTL--KISENMIP------------------------------------VVAEKY----------------------------------------------LGGT---DDLTKKK----------------D---LFQDL-----MA-D------------------------------VVFGVP----SVIVSRSH-RDA-----GA------------------------------S--TYMYEF-------EY-RPSFVSA------MR-PKAV--------I-GDHG---------DEI-FSVFG------SPFL--KD------GASEEE---------------------- 718
719 KIPLQFSEDC--------------------LYLNIYT----------P-----------A-DLT---KSD--RLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LVL-GG------AS------T----YDGLVLST-----HE----NVVVVV------I-Q---YR-LG-------------IWGFFST--------GDEH---S-----R-G---NWGHLD--QVAA----------------------------------------------L-----------------------------H--WVQDN-----------------------------IAKFG---------------------GD------------------------------------------------------PGS----V-TI--F-G--ES-----------------AG-----------------------------G-ESVSV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPL-------A---------------K---------------NLFQRAISE-----------------------------------------------------------------------------------------S-GVAL---------TAGLVKK------N--T---------------------------RPLAE---------KIA----VISGC----------------------------------------------------------KNT----------------------------------------------TSAAMVHCLR---Q------K------------------------------------------------TEEELLGT----T-LKL-NLFKL---------DLHGDSRQSHPFVP---------------------------T------VL----DG--------------V--LL----PKMPE-EI------------------------------------------LAEKN------F-NT---------------------------------------------------------------------------------------------------------------------------VP--YI------------------V-------------------GINKQEFGW-----------------------------ILPT-MMNYPPSDVKLD---------QMTA----------------------MSLLKKSSFLL--NLPEDAIA------------------------------------VAIEKY----------------------------------------------LRDK---DYTGRNK----------------D---QLLEL-----IG-D------------------------------VVFGVP----SVIVSRGH-RDA-----GA------------------------------P--TYMYEF-------QY-SPSFSSE------MK-PDTV--------V-GDHG---------DEI-YSVFG------APIL--RG------GTSEEE---------------------- 719
720 IIPHKFSEDC--------------------LYLNIYT----------P-----------A-DLT---QNS--RLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LVI-DG------AS------T----YDGVPLAV-----HE----NVVVVV------I-Q---YR-LG-------------IWGFFST--------EDEH---S-----R-G---NWGHLD--QVAA----------------------------------------------L-----------------------------H--WVQDN-----------------------------IANFG---------------------GN------------------------------------------------------PGS----V-TI--F-G--ES-----------------AG-----------------------------G-ESVSV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPL-------A---------------K---------------NLFHRAIAQ-----------------------------------------------------------------------------------------S-SVIF---------NPCLFGR------A--A---------------------------RPLAK---------KIA----ALAGC----------------------------------------------------------KTT----------------------------------------------TSAAMVHCLR---Q------K------------------------------------------------TEDELLEV----S-LKM-KFGTV---------DFLGDPRESYPFLP---------------------------T------VI----DG--------------V--LL----PKAPE-EI------------------------------------------LAEKS------F-NT---------------------------------------------------------------------------------------------------------------------------VP--YM------------------V-------------------GINKHEFGW-----------------------------IIPM-FLDFPLSERKLD---------QKTA----------------------ASILWQAYPIL--NISEKLIP------------------------------------AAIEKY----------------------------------------------LGGT---EDPATMT----------------D---LFLDL-----IG-D------------------------------IMFGVP----SVIVSRSH-RDA-----GA------------------------------P--TYMYEY-------QY-RPSFVSD------DR-PQEL--------L-GDHA---------DEL-FSVWG------APFL--KE------GASEEE---------------------- 720
721 KIHLEFSEDC--------------------LYLNIYT----------P-----------A-DFT---KNS--RLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------MTL-GG------AS------T----YDGRVLSA-----YE----NVVVVA------I-Q---YR-LG-------------IWGFFST--------GDEH---S-----R-G---NWGHLD--QVAA----------------------------------------------L-----------------------------H--WVQDN-----------------------------IANFG---------------------GD------------------------------------------------------PGS----V-TI--F-G--ES-----------------AG-----------------------------G-FSVSV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPL-------T---------------K---------------NLFHRAISE-----------------------------------------------------------------------------------------S-GVVF---------LPGLLTK------D--V---------------------------RPAAK---------QIA----DMAGC----------------------------------------------------------ETT----------------------------------------------TSAIIVHCLR---Q------K------------------------------------------------TEEELLEI----M-KKM-NLIKL---------SSQRDNKESYHFLS---------------------------T------VV----DN--------------V--VL----PKDPK-EI------------------------------------------LAEKN------F-NT---------------------------------------------------------------------------------------------------------------------------VP--YI------------------V-------------------GINKQECGW-----------------------------LLPT-MMGFVPADVELD---------KKMA----------------------ITLLEKFASLY--GIPEDIIP------------------------------------VAIEKY----------------------------------------------RKGS---DDSIKIR----------------D---GILAF-----IG-D------------------------------VSFSIP----SVMVSRDH-RDA-----GA------------------------------P--TYMYEY-------QY-YPSFSSP------QR-PKHV--------V-GDHA---------DDL-YSVFG------APIL--RD------GASEEE---------------------- 721
722 KVHLQFSEDC--------------------LYLNIYT----------P-----------A-DFT---KDS--RMPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LTQ-GG------AS------T----YDGQVLSA-----YE----NVVVVA------I-Q---YR-LG-------------IWGFFST--------GDEH---S-----R-G---NWGHLD--QVAA----------------------------------------------L-----------------------------H--WVQDN-----------------------------IANFG---------------------GD------------------------------------------------------PGS----V-TI--F-G--ES-----------------AG-----------------------------G-FSVSV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPL-------S---------------K---------------NLYHRAISE-----------------------------------------------------------------------------------------S-GVVL---------ITELFTK------D--V---------------------------RPAAK---------QIA----DMAGC----------------------------------------------------------KTT----------------------------------------------TSAIIVHCLR---Q------K------------------------------------------------TEEELLEI----M-EKM-NLIKL---------SSQRDTKESYHFLS---------------------------T------VI----DD--------------V--VL----PKDPK-EI------------------------------------------LAEKN------F-NT---------------------------------------------------------------------------------------------------------------------------VP--YI------------------V-------------------GINKQECGW-----------------------------LLPT-MMRFVPPDVKLD---------KKMA----------------------IMLLEKFASIY--GIPEDIIP------------------------------------VAIEKY----------------------------------------------RKGS---DDPIKIR----------------D---GILAF-----IG-D------------------------------VLFCIP----SVMVSRDH-RDA-----GA------------------------------P--TYVYEY-------QY-YPSFSSP------QR-PKDV--------V-GDHA---------DDV-YSVFG------APIL--RD------GASEEE---------------------- 722
723 KIHLEFSEDC--------------------LYLNIYT----------P-----------A-DFS---KNS--RLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LKL-GG------AS------S----FDGRALSA-----YE----NVVVVA------I-Q---YR-LS-------------IWGFFST--------GDEH---S-----R-G---NWGHLD--QVAA----------------------------------------------L-----------------------------H--WVQDN-----------------------------IANFG---------------------GD------------------------------------------------------PGS----V-TI--F-G--ES-----------------AG-----------------------------G-YSVSI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-ILSPL-------S---------------K---------------NLFHRAISE-----------------------------------------------------------------------------------------S-GVAF---------IPGMFTK------D--V---------------------------RPITE---------QIA----VTAGC----------------------------------------------------------KTT----------------------------------------------TSAVIVHCMR---Q------K------------------------------------------------TEEELLEI----M-HKL-NLYKL---------SLQGDTKNSDQFVT---------------------------S------VL----DG--------------V--VL----PKDPK-EI------------------------------------------LAEKN------F-NT---------------------------------------------------------------------------------------------------------------------------VP--YI------------------V-------------------GINKQECGW-----------------------------LLPT-MTGFLPADVKLD---------KKKA----------------------IALLEQFASMT--GIPEDIIP------------------------------------VAVEKY----------------------------------------------TKGS---DDPDQIR----------------E---GVLDA-----MG-D------------------------------VAFGVP----SVIVSRGH-RDT-----GA------------------------------P--TYMYEY-------QY-YPSFSSP------QR-PKNV--------V-GDHA---------DDV-YSVFG------APIL--RE------GASEEE---------------------- 723
724 NVPLEYSEDC--------------------LYLNIYS----------P-----------T-DLT---SKD--RLPVMVW----V-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LLS-GG------AS------T----FDGLALST-----HE----NVVIVV------I-Q---YR-LG-------------IWGFLST--------GDEH---S-----R-G---NWGHLD--QVAA----------------------------------------------L-----------------------------Q--WVQNN-----------------------------IANFG---------------------GD------------------------------------------------------PSS----V-TL--F-G--ES-----------------AG-----------------------------G-ESVSV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPL-------T---------------K---------------NLFQRAISE-----------------------------------------------------------------------------------------S-GVAL---------TPCLFRE------T--T---------------------------RRAAE---------QVA----IATGC----------------------------------------------------------VAT----------------------------------------------TSADIVHCLR---E------K------------------------------------------------TEEELLAT----T-LKM-KFFAL---------DLLGDPRESYPFLT---------------------------T------VI----DG--------------V--VL----PKAPE-EI------------------------------------------LAEKS------F-NT---------------------------------------------------------------------------------------------------------------------------VP--YI------------------V-------------------GINKQEFGW-----------------------------FIPM-MMGYPLSEGKLD---------QKSA----------------------TSLLWKSYPLT--NISKELTP------------------------------------VATEKY----------------------------------------------LGGS---DCPDKKK----------------D---LFLDM-----MG-D------------------------------VLFAVP----SVIVARYH-RDA-----GA------------------------------P--TYMYEF-------KY-HPSFVSD------MR-PKTV--------I-ADHG---------DEV-YSVWG------TPFL--KE------GASEEE---------------------- 724
725 SIPPLFSEDC--------------------LYLNIYS----------P-----------A-DLT---KSS--LLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LMT-GG------AS------L----YNGLALSA-----HE----NVVVVT------I-Q---YR-LG-------------IWGLFST--------GDEH---S-----R-G---NWAHLD--QLAA----------------------------------------------L-----------------------------R--WVQDN-----------------------------IANFG---------------------GN------------------------------------------------------PDS----V-TV--F-G--SS-----------------AG-----------------------------G-VSVSV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPL-------A---------------K---------------NLFHRAISE-----------------------------------------------------------------------------------------S-SVVL---------GTNLRNK------N--I---------------------------QAVTE---------MIA----TVSGC----------------------------------------------------------NDT----------------------------------------------SSTAMVQCLR---Q------K------------------------------------------------TENELLEI----T-VKL-EVTKV---------GGAASAKKDNTSMS---------------------------T------VI----DG--------------V--VL----PKAPE-EI------------------------------------------LAEKS------F-ST---------------------------------------------------------------------------------------------------------------------------VP--YI------------------V-------------------GFNKQEFGW-----------------------------IIPT-MLGDLLSEGKMN---------EETA----------------------SLLLRRFHSDL--NISESLIP------------------------------------AVIEKY----------------------------------------------LRGT---DDPAKKR----------------D---LLLDM-----FS-D------------------------------VFFGIP----AVLLSRSL-RDA-----GV------------------------------S--TYMYEF-------RY-RPSFVSD------KR-PQTV--------E-GDHG---------DEI-FSVFG------IPLL--KE------GTSEEE---------------------- 725
726 ILPLKISEDC--------------------LYLNIYS----------P-----------A-DLT---KSS--QLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LVI-GG------RS------P----YNGLALSA-----HE----NVVVVT------I-Q---YR-LG-------------IWGLFST--------GDEH---S-----Q-G---NWAHLD--QLAA----------------------------------------------L-----------------------------R--WVQDN-----------------------------IANFG---------------------GN------------------------------------------------------PDS----V-TI--F-G--ES-----------------SG-----------------------------G-ISVSV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPL-------G---------------K---------------DLFHRAISE-----------------------------------------------------------------------------------------S-GVVI---------NTNVGKK------N--I---------------------------QAVNE---------IIA----TLSQC----------------------------------------------------------NDT----------------------------------------------SSAAMVQCLR---Q------K------------------------------------------------TESELLEI----S-GKL---------------------VQYNISLS---------------------------T------VI----DG--------------V--VL----PKAPE-EI------------------------------------------LAEKS------F-NT---------------------------------------------------------------------------------------------------------------------------VP--YI------------------V-------------------GFNKQEFGW-----------------------------IIPM-MLQNLLPEGKMN---------EETA----------------------SLLLRRFHSEL--NISESMIP------------------------------------AVIEKY----------------------------------------------LRGV---DDPAKKS----------------E---LILDM-----FG-D------------------------------IFFGIP----AVLMSRSL-RDA-----GV------------------------------S--TYMYEF-------RY-RPSFVSD------KR-PQMV--------E-GDHG---------DEI-FSVFG------APLL--KE------GASEEE---------------------- 726
727 HIQFRTSEDC--------------------LYLNVYS----------P-----------A-D-----KKN--KLPVMVW----I-------H---------------------------------------------------------G--------------------G----N-----------------------------------------------------------------------------FVF-GG------AS------R----YDGSALSA-----YE----DIVVVI------I-Q---YR-LG-------------LLGFFNT--------GDEH---A-----R-G---NWAFLD--QVEA----------------------------------------------L-----------------------------R--WVQEN-----------------------------IEHFG---------------------GD------------------------------------------------------PGS----V-TL--F-G--VS-----------------AG-----------------------------S-CSVFA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VLSTL-------S---------------K---------------GLFHKAILE-----------------------------------------------------------------------------------------S-GVLI---------PSNKDLL-----LS--A---------------------------DVK-----------KIA----DIFKC----------------------------------------------------------ETN----------------------------------------------SSLSLVNCLR---N------R------------------------------------------------EAMDIVFN----S-TEI-------------------------PFLP---------------------------L------VL----DG--------------V--FL----HKSPE-DI------------------------------------------LAGKE------F-NV---------------------------------------------------------------------------------------------------------------------------VP--FM------------------I-------------------GVTNNEFGW-----------------------------NVRS-TSTIPALRDVGD---------KRSI----------------------TSALEFLLPMM--NLPPELLP------------------------------------VIMDEY----------------------------------------------LGNT---DDPAELR----------------D---RFLEL-----LG-D------------------------------VFIVIP----SIKALSYY-RES-----GA------------------------------P--TYLFEY-------QH-RPTSYSD------TK-PEYV--------K-ADHG---------DEV-GFVF------------------------------------------------- 727
728 HIQFRTSEDC--------------------LYLNVYS----------P-----------A-D-----KKN--KLPVMVW----I-------H---------------------------------------------------------G--------------------G----N-----------------------------------------------------------------------------FVF-GG------AS------R----YDGSALSA-----YE----DIVVVI------I-Q---YR-LG-------------LLGFFNT--------GDEH---A-----R-G---NWAFLD--QVEA----------------------------------------------L-----------------------------R--WVQEN-----------------------------IEHFG---------------------GD------------------------------------------------------PGS----V-TL--F-G--VS-----------------AG-----------------------------S-CSVFA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KIA----DIFKC----------------------------------------------------------ETN----------------------------------------------SSLSLVNCLR---N------R------------------------------------------------EAMDIVFN----S-TEI-------------------------PFLP---------------------------L------VL----DG--------------V--FL----HKSPE-DI------------------------------------------LAGKE------F-NV---------------------------------------------------------------------------------------------------------------------------VP--FM------------------I-------------------GVTNNEFGW-----------------------------NVRS-TSTIPALRDVGD---------KRSI----------------------TSALEFLLPMM--NLPPELLP------------------------------------VIMDEY----------------------------------------------LGNT---DDPAELR----------------D---RFLEL-----LG-D------------------------------VFIVIP----SIKALSYY-RES-----GA------------------------------P--TYLFEY-------QH-RPTSYSD------TK-PEYV--------K-ADHG---------DEV-GFVFG------GPYL--AGDISLRDEATEEE---------------------- 728
729 KVRLQMSEDC--------------------LYLNIYT----------P-----------V-STE---KQE--KLPVFVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LVL-GA------AS------S----YDGSALAA-----FD----NVVVVT------I-Q---YR-LG-------------IAGYFST--------GDKY---A-----R-G---NWGYLD--QVAA----------------------------------------------L-----------------------------Q--WIQEN-----------------------------IIHFG---------------------GD------------------------------------------------------PGS----V-TI--C-G--ES-----------------AG-----------------------------G-ISVSA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPL-------A---------------K---------------GLFHKAISE-----------------------------------------------------------------------------------------S-GTA----------IRALFTD------K--P---------------------------EEEAQ---------RIA----AASGC----------------------------------------------------------EKS----------------------------------------------SSAALVECLR---E------K------------------------------------------------TEEEMEQI----T-------LKM-----------------PPMFIS---------------------------S------AV----DG--------------V--FF----PRSPR-QL------------------------------------------LSEKA------I-NA---------------------------------------------------------------------------------------------------------------------------VP--YI------------------I-------------------GVTNCEFGW-----------------------------GLPN-MMKFPDFTHGLD---------KEVS----------------------YQVLKNFIELSFESFTSDTVD------------------------------------LIFNEY----------------------------------------------IGKA---ESRAQVR----------------D---GLLDA-----LG-D------------------------------HFFVFS----AVEVARYH-RDA-----GH------------------------------P--VYFYEF-------QH-RPSSATG------VV-PEFV--------K-ADHG---------SEI-AFVFG------KPFL--AG------NVTEEE---------------------- 729
730 KVRLQMSEDC--------------------LYLNIYT----------P-----------V-STE---KQE--KLPVFVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LVL-GA------AS------S----YDGSALAA-----FD----NVVVVT------I-Q---YR-LG-------------IVGYFST--------GDKY---A-----R-G---NWGYLD--QVAA----------------------------------------------L-----------------------------Q--WIQEN-----------------------------IIHFG---------------------GD------------------------------------------------------PGS----V-TI--C-G--ES-----------------AG-----------------------------G-ISVSA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPL-------A---------------K---------------GLFHKAISE-----------------------------------------------------------------------------------------S-GTA----------IRTLFTD------K--P---------------------------EEEAQ---------RIA----AASGC----------------------------------------------------------EKS----------------------------------------------SSAALVECLR---E------K------------------------------------------------TEEEMEQI----T-------LKM-----------------PSMFIS---------------------------S------TV----DG--------------V--FF----PKSPR-EL------------------------------------------LSEKA------I-NA---------------------------------------------------------------------------------------------------------------------------VP--YI------------------I-------------------GVNNCEFGW-----------------------------VIPE-MMKVPDFTEGLD---------KEVA----------------------RQVLQSSFVLSFKSVPSDIVD------------------------------------LVFNEY----------------------------------------------IGKA---ESRAQVR----------------D---GLLDA-----IG-D------------------------------HMFVFP----AIEVARYH-RDA-----GH------------------------------P--VYFYEF-------QH-RPSSATG------VV-PEFV--------K-ADHG---------DEI-AFVFG------KPFL--AG------NATEEE---------------------- 730
731 KVRLQMSEDC--------------------LYLNIYT----------P-----------V-STE---KQE--KLPVFVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LVL-GA------AS------S----YDGSALAA-----FD----NVVVVT------I-Q---YR-LG-------------IVGYFST--------GDKY---A-----R-G---NWGYLD--QVAA----------------------------------------------L-----------------------------Q--WIQEN-----------------------------IIHFG---------------------GD------------------------------------------------------PGS----V-TI--C-G--ES-----------------AG-----------------------------G-ISVSA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIA----AASGC----------------------------------------------------------EKS----------------------------------------------SSAALVECLR---E------K------------------------------------------------TEEEMEQI----T-------LKMEMTTLKVCYTSPEKCEQPSMFIS---------------------------S------TV----DG--------------V--FF----PKSPR-EL------------------------------------------LSEKA------I-NA---------------------------------------------------------------------------------------------------------------------------VP--YI------------------I-------------------GVNNCEFGW-----------------------------VIPE-MMKVPDFTEGLD---------KEVA----------------------RQVLQSSFVLSFKSVPSDIVD------------------------------------LVFNEY----------------------------------------------IGKA---ESRAQVR----------------D---GLLDA-----IG-D------------------------------HMFVFP----AIEVARYH-RDA-----GH------------------------------P--VYFYEF-------QH-RPSSATG------VV-PEFV--------K-ADHG---------DEI-AFVFG------KPFL--AG------NATEEE---------------------- 731
732 HQIFPISEDC--------------------LILNIYS----------P-----------A-EAT---AGA--GKPVMVW----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------LLL-GA------AT------S----QDGSALAA-----YG----DVVVVT------V-Q---YR-LG-------------LPGFFST--------GDKH---A-----A-G---NWGFLD--VVAA----------------------------------------------L-----------------------------H--WVQGN-----------------------------ITPFG---------------------GD------------------------------------------------------PNS----V-TI--F-G--GS-----------------AG-----------------------------A-CIVSA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPL-------A---------------A---------------GLFHRAIAQ-----------------------------------------------------------------------------------------S-GVIT---------QPGLLDS------D--P---------------------------WPLAQ---------SFA----DFLAC----------------------------------------------------------SSN----------------------------------------------SSAEMVQCLR---Q------K------------------------------------------------ASKELILP----------KTMRI-------------------TA-A---------------------------Y------TI----DG--------------T--FF----PKTPK-EL------------------------------------------LRERR------F-HS---------------------------------------------------------------------------------------------------------------------------VP--FL------------------L-------------------GVNNHEFGW-----------------------------LIPR-GWGILDKMEQMN---------VEDV----------------------LATLRPYLTKL--DVPHEVMS------------------------------------TIMDEY----------------------------------------------QGSR---SHAHAKR----------------E---AFQEL-----LS-D------------------------------IILNFP----ILNFSRNL-RDS-----GV------------------------------S--VFFYEF-------QH-RPSSFVK------IK-PAWV--------K-ADHG---------AET-AFIFG------GPFLTDESSTLAFPEATEEE---------------------- 732
733 QQIFSVSEDC--------------------LVLNVYS----------P-----------A-EVP---AGS--GRPVMVW----V-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------LIT-GA------AT------S----YDGSALAA-----YG----DVVVVT------V-Q---YR-LG-------------VLGFFST--------GDEH---A-----P-G---NQGFLD--VVAA----------------------------------------------L-----------------------------R--WVQEN-----------------------------IAPFG---------------------GD------------------------------------------------------LNC----V-TV--F-G--GS-----------------AG-----------------------------G-SIISG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPV-------A---------------A---------------GLFHRAITQ-----------------------------------------------------------------------------------------S-GVIT---------TPGIIDS------H--P---------------------------WPLAQ---------KIA----NTLAC----------------------------------------------------------SSS----------------------------------------------SPAEMVQCLQ---Q------K------------------------------------------------EGEELVLS----------KKLKN-------------------TIYP---------------------------L------TV----DG--------------T--VF----PKSPK-EL------------------------------------------LKEKP------F-HS---------------------------------------------------------------------------------------------------------------------------VP--FL------------------M-------------------GVNNHEFSW-----------------------------LIPR-GWGLLDTMEQMS---------REDM----------------------LAISTPVLTSL--DVPPEMMP------------------------------------TVIDEY----------------------------------------------LGSN---SDAQAKC----------------Q---AFQEF-----MG-D------------------------------VFINVP----TVSFSRYL-RDS-----GS------------------------------P--VFFYEF-------QH-RPSSFAK------IK-PAWV--------K-ADHG---------AEG-AFVFG------GPFLMDESSRLAFPEATEEE---------------------- 733
734 YPNLEVSEDC--------------------LYLNIYA----------P-----------A-HAN---TGS--KLPVMVW----F-------P---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FET-GS------AS------I----FDGSALAA-----YE----DVLIVT------T-Q---YR-LG-------------IFGFFKT--------GDQH---A-----P-G---NWAFLD--QLAA----------------------------------------------L-----------------------------T--WVQEN-----------------------------IEFFG---------------------GD------------------------------------------------------PHS----V-TI--F-G--ES-----------------AG-----------------------------A-ISVSG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-VLSPM-------A---------------S---------------GLFHKAIME-----------------------------------------------------------------------------------------S-GVAI---------IPFL-RA-----PD--D---------------------------ERNEDLQ-------VIA----RICGC----------------------------------------------------------NVS----------------------------------------------DSVALLQCLR---A------K------------------------------------------------SSEELLDI----N-----KKTKS---------------------FT---------------------------R------VV----DG--------------F--FF----PDEPL-DL------------------------------------------LTEKT------F-NS---------------------------------------------------------------------------------------------------------------------------IP--SV------------------I-------------------GVNNHECGF-----------------------------LLP--MKEFPEILGGSN---------KSLA----------------------LHLIHRVL-----HIPNQYLY------------------------------------LVADQY----------------------------------------------FYNK---HSPVEIR----------------D---SFLDL-----LG-D------------------------------VFFVVP----GVVTARYH-RDA-----GA------------------------------P--VYFYEF-------QH-PPECLKD------TR-PAFV--------K-ADHS---------DEI-RFVFG------GAFL--KGNIVMFEGATEEE---------------------- 734
735 YPKLEASEDC--------------------LYLNIYA----------P-----------A-HAD---NGS--NLPVMVW----F-------P---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FKM-GS------AS------S----FDGSALAA-----YE----DVLIVT------T-Q---YR-LG-------------IFGFFDT--------GDEH---A-----R-G---NWALLD--QVAA----------------------------------------------L-----------------------------T--WVRDN-----------------------------IEFFG---------------------GD------------------------------------------------------PRS----V-TI--F-G--ES-----------------AG-----------------------------A-ISVSS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-ILSPI-------A---------------N---------------GLFHKAIME-----------------------------------------------------------------------------------------S-GVAI---------LPLLMRP-----PG--D---------------------------ERKKDLQ-------VLA----RICGC----------------------------------------------------------HAS----------------------------------------------DSAALLQCLR---A------K------------------------------------------------PSEELMDI----S-----KKLTF---------------------SI---------------------------P------VI----DD--------------F--FF----PDEPV-AL------------------------------------------LTQKA------F-NS---------------------------------------------------------------------------------------------------------------------------VP--SI------------------I-------------------GVNNHECAF-----------------------------LLS---TEFSEILGGSN---------RSLA----------------------LYLVHTFL-----NIPTQYLH------------------------------------LVADHY----------------------------------------------FYNK---HSPVEIR----------------D---SFLDL-----LG-D------------------------------VLFVVP----GVVTARYH-RDA-----GA------------------------------P--VYFYEF-------QH-PPQCLND------TR-PAFV--------K-ADHS---------DEI-RFVFG------GAFL--KGDIVMFEGATEEE---------------------- 735
736 YPKFGVSEDC--------------------LYLNIYA----------P-----------A-HAD---TGS--KLPVLVW----F-------P---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FKT-GS------AS------I----FDGSALAA-----YE----DVLVVV------V-Q---YR-LG-------------IFGFFTT--------WDQH---A-----P-G---NWAFKD--QVAA----------------------------------------------L-----------------------------S--WVQKN-----------------------------IEFFG---------------------GD------------------------------------------------------PSS----V-TI--F-G--ES-----------------AG-----------------------------A-ISVSS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-ILSPM-------A---------------K---------------GLFHKAIME-----------------------------------------------------------------------------------------S-GVAI---------IPYL-EA-----HD--Y---------------------------EKSEDLQ-------VVA----HFCGN----------------------------------------------------------NAS----------------------------------------------DSEALLRCLR---T------K------------------------------------------------PSKELLTL----S-----QKTKS---------------------FT---------------------------R------VV----DG--------------A--FF----PNEPL-DL------------------------------------------LSQKA------F-KA---------------------------------------------------------------------------------------------------------------------------IP--SI------------------I-------------------GVNNHECGF-----------------------------LLP--MKEAPEILSGSN---------KSLA----------------------LHLIQNIL-----HIPPQYLH------------------------------------LVANEY----------------------------------------------FHDK---HSLTEIR----------------D---SLLDL-----LG-D------------------------------VFFVVP----ALITARYH-RDA-----GA------------------------------P--VYFYEF-------RH-RPQCFED------TK-PAFV--------K-ADHA---------DEV-RFVFG------GAFL--KGDIVMFEGATEEE---------------------- 736
737 YPKFHVSEDC--------------------LYLNIYA----------P-----------A-HAD---TGS--KLPVMVW----F-------P---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FES-GS------AS------L----FDGSALAA-----YE----DVLVVT------T-Q---YR-LG-------------MLGFFNT--------GNQH---A-----L-G---NWAFMD--QMAA----------------------------------------------L-----------------------------H--WVQEN-----------------------------IEFFG---------------------GD------------------------------------------------------PRS----V-TI--F-G--ES-----------------AG-----------------------------A-ISVSS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-ILSPM-------A---------------N---------------GLFHKAIME-----------------------------------------------------------------------------------------S-GVAV---------IPYL-KA-----SD--D---------------------------ERNEALQ-------VVA----DICGC----------------------------------------------------------NSS----------------------------------------------DSVALLQCLR---A------K------------------------------------------------PSEELLII----S-----QKTKA---------------------FT---------------------------R------VV----DG--------------F--VF----PEEPV-DL------------------------------------------LTKKT------F-NP---------------------------------------------------------------------------------------------------------------------------IP--SI------------------I-------------------GVNNHECGF-----------------------------LLP--MKEFPEILGDSN---------KSLA----------------------LRLIHTIL-----HVPVQHLH------------------------------------LVANEY----------------------------------------------FYNK---HSLFEIR----------------N---SFLDL-----LG-D------------------------------VFFVVP----ALVTAQYH-RDA-----GA------------------------------S--VYFYEF-------QH-RPHCLKD------IK-PAFV--------K-ADHS---------DEI-RFVFG------GAFL--KGDVVMFEGATEEE---------------------- 737
738 YKWLHFSEDC--------------------LYLNVYA----------P-----------V-LAP---GAP--LLPVMVW----F-------P---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FLA-GS------AS------T----YEGSELAA-----RG----KVVLVF------L-Q---YR-LG-------------ILGFFST--------GNSH---A-----R-G---NWGLLD--QIAA----------------------------------------------L-----------------------------R--WVQEN-----------------------------IEAFG---------------------GD------------------------------------------------------PDS----V-TL--F-G--QS-----------------AG-----------------------------A-MSVSG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-MVSPL-------A---------------Q---------------GLFHQAISQ-----------------------------------------------------------------------------------------S-GTAV---------LKAFITP------D--P---------------------------LTSAK---------KIA----HLAGC----------------------------------------------------------DHN----------------------------------------------STKVMVECLR---S------L------------------------------------------------SAEEVTLV----S-KRM-SFFQA---------NSHKDPKEIVWFLS---------------------------P------VV----DG--------------V--VF----PEDPV-VL------------------------------------------LTRGQ------V-KP---------------------------------------------------------------------------------------------------------------------------VP--YL------------------L-------------------GVNNAEFEW-----------------------------NLPF-LMKIQLNQRMMN---------QTNI----------------------NKILWSFNVLL--NITKEQVP------------------------------------VVAREY----------------------------------------------LNDAISNHDWKMFR----------------N---RLIDL-----IG-D------------------------------ATFVYA----TLQAARYH-RDA-----GS------------------------------P--VYLYEF-------KH-HASSGII------IK-P-YN--------G-ADHG---------DEL-SYLFG------SPFS--KGS-----SAGEE----------------------- 738
739 YKWLRFSEDC--------------------LYLNVYA----------P-----------A-RAP---GDP--QLPVMVW----F-------P---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FIV-GA------AS------S----YEGSDLAA-----RE----KVVLVF------L-Q---HR-LG-------------IFGFLST--------DDSH---A-----R-G---NWGLLD--QMAA----------------------------------------------L-----------------------------R--WVQEN-----------------------------IAAFG---------------------GD------------------------------------------------------PGN----V-TL--F-G--QS-----------------AG-----------------------------A-MSISG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-MMSPL-------A---------------S---------------GLFHRAISQ-----------------------------------------------------------------------------------------S-GTAL---------FRLFITS------N--P---------------------------LKVAK---------KVA----HLAGC----------------------------------------------------------NHN----------------------------------------------STQILVNCLR---A------L------------------------------------------------SGTKVMRV----S-NKM-RFLQL---------NFQRDPEEIIWSMS---------------------------P------VV----DG--------------V--VI----PDDPL-VL------------------------------------------LTQGK------V-SS---------------------------------------------------------------------------------------------------------------------------VP--YL------------------L-------------------GVNNLEFNW-----------------------------LLPY-IMKFPLNRQAMR---------KETI----------------------TKMLWSTRTLL--NITKEQVP------------------------------------LVVEEY----------------------------------------------L-DNVNEHDWKMLR----------------N---RMMDI-----VQ-D------------------------------ATFVYA----TLQTAHYH-RDA-----GL------------------------------P--VYLYEF-------EH-HA-RGII------VK-PRTD--------G-ADHG---------DEM-YFLFG------GPFA--TGL-----SMGKE----------------------- 739
740 -------EDC--------------------LYMNVWV----------P-----------QGVDQ---IE---SMPVMVF----Y-------Y---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FIL-GT------GE----------MYPGSLLAT-----QG----DVIVVN------F-N---YR-LS-------------TLGWLSSVMYNGLMKGDDV---L-----P-G---NYGLWD--ARAA----------------------------------------------L-----------------------------Q--WVQQN-----------------------------IAQFG---------------------GD------------------------------------------------------PSR----V-TI--F-G--QS-----------------AG-----------------------------G-SMVSH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-VISPQ-------F---------------D---------------GLFQRAIAI-----------------------------------------------------------------------------------------S-GASS---------SFFSLTRQAKGNLL--------------------------------------------MMS----DIFSC----------------------------------------------------------NST----------------------------------------------DSQEIVDCLRG--I-------------------------------------------------------DDDMLDFWGIIGD-IAFRERLP-------------GFL-----------------------------------P------TI----DG--------------E--MV----LGEPA-EM------------------------------------------FAQGY------G-KN---------------------------------------------------------------------------------------------------------------------------ID--FI------------------T-------------------GSTYHDAAG------------------FI------FRNVLARRNNED--NIAATPESLDASLNFFFNF---------------------------------------------------------------------AVN-NRELVDTVYDLY-------------------------------------------------PDLITDDNMTR----------------TL--TATEF-----GT-D------------------------------MVFRGP----SFYEATEHARNS----------------------------------QEDGGSTYHYEY-------HFGHTFLAGH---------PDWV--------T-GSHV---------DDL-YTVFG------DVF--------------------------------------- 740
741 -------EDC--------------------LYLNVWV----------P-----------EGVDE---VS---DLPVMVY----Y-------F---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FVL-GT------GE----------MYPSQKLAT-----EA----NVIVVN------F-N---YR-LS-------------TLGWLSS--------GDDV---L-----P-G---NFGMWD--ARAA----------------------------------------------L-----------------------------Q--WVQRN-----------------------------IAQFG---------------------GD------------------------------------------------------PDR----V-TI--F-G--QS-----------------AG-----------------------------G-CMVSH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-VISPQ-------F---------------E---------------GLFQRAIAI-----------------------------------------------------------------------------------------S-GVAN---------TYFGLTRQPRGNLL--------------------------------------------MMS----EVFGC----------------------------------------------------------ETE----------------------------------------------DAQEIVDCLRP--F-------------------------------------------------------DNDLLDFWGIIGD-V-MRGRMP-------------SFI-----------------------------------P------TI----DG--------------E--MI----IGEPS-EL------------------------------------------YAEGY------G-KD---------------------------------------------------------------------------------------------------------------------------ID--YI------------------T-------------------GNTHHDSAG------------------II------LMNPIAMRFLGDRFSVAATQESLSEFMELFFSF---------------------------------------------------------------------STN-GEELTDIVYDLY-------------------------------------------------PDMISTDNLTR----------------TL--NTVEW-----ST-D------------------------------MWMRGP----SFYEATQHGLNA----------------------------------GPDGGSTYHYEF-------QFRHTFLAGY---------PDWV--------D-GSHV---------DDL-YTVFG------QPF--------------------------------------- 741
742 --VELQDEDC--------------------LHLNIFS----------------------------PSNSQGKRYPVMVY----I-------H---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------YRV-GS--------------G--NSFLGHVLAQ-----H-----GIVVVN------I-N---YR-LE-------------ALGFLTT--------GDDL---------LPG---NYGLLD--QIAA----------------------------------------------L-----------------------------K--WVKQN-----------------------------IAAFA---------------------GD------------------------------------------------------PSR----V-TI--A-G--NS-----------------AG-----------------------------G-ASVGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-NVSPA-------A---------------R---------------GLFNQAIIQ-----------------------------------------------------------------------------------------S-GS---PLAFWATHNETANLRNFFRHYA---------------------------------------------------NVHGC--------------------------------------------------------------------------------------------------------QQNSISELIACLREIPWQLFNFELRFELPRISPSRTDI-R---------------------------------------------------------------------------------------------------------P------RV----DK-----------------SV------------------------------------------------------LESMAVDLYK-TAHI---------------------------------------------------------------------------------------------------------------------------NVKSIM------------------T-------------------GVVKSEWSRHITLFL-----HEDLLPNKPHLAIHHVFADRFWWDPA-ITQ-------------------------------------------------------------------------------------------------VVVHEY--TNWSRRDDQV----------------------------------------------------------------ENRRNYLQC-----IS-D------------------------------MAMLAP----TVKLAD-MCSKR-------------------------------------GVSVYLYQF-------NHESHSDETF---------QPWQ--------A-NYHQ---------IEL-NYVFGSPFTNIDTEQGLQMNFTRED---------------------------- 742
743 STAAFAEENC--------------------LTLNVFA----------P---------------RWKLAEFPKGLPVLVY----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------YEI-GF--------------T--SYMDDYSLTGTLPL-K-----DVIVVT------M-N---YR-LG-------------PLGFLTI--------ADGI---------ANG---NYGLWD--QTLA----------------------------------------------L-----------------------------Q--WVQDN-----------------------------IASFG---------------------GN------------------------------------------------------PES----V-TL--S-G--TS-----------------AG-----------------------------A-TSTDF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-SLSPH-------S---------------N---------------QLFQRSISM-----------------------------------------------------------------------------------------S-GTAF---------CNFAIRPKDVEVGVCKE---------------------------FAQFQ----------------GYTGT-----------------------------------------------------------------------------------------------------------DSQSLFDWYMA--Q-------------------------------------------------------NVSKFKEVAGFQSTAAGAVPFI---------------------------------------------------P------NF----DGDFFPK------------PFDILRREAPKKDALIT---------------------------------------VVTMESVGMIIF-NP-------------------------------------------------------------------------------------------------------------------------------LFANAYNNFEGFINETYGPDV-------------------TDYYADVKK------------------------------------------------------------------------------------------------------------------------------------------KLTGFY-LKDVNASDKA-----------------------------------------------------------------TVNRRVVDY-----VS-D------------------------------SVFNSGTLDAVKSYVKY------------------------------------------GNKVYLGSF-------NYFNDATKDMVELMQPFK-------------E-ASHS---------SDF-KYYFGSGVMANFTPTDEE----------------------------------- 743
744 RTPTPEEAGC--------------------LTLNVFT----------P---------------RNASSEFKNGRPVMVY----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------YEL-CA--------------S--SDFCAYSLSGTLPL-K-----DVVVVS------I-N---YR-LG-------------VFGFLTT--------GDNV---------CPG---NFGLWD--QTLA----------------------------------------------L-----------------------------K--WVQKH-----------------------------ISSFG---------------------GD------------------------------------------------------PNC----V-TV--F-G--QS-----------------AG-----------------------------G-ASTDL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-SLSPH-------S---------------R---------------DLFQRFIPI-----------------------------------------------------------------------------------------S-GTAH---------CDFAIRASENQAKIFRE---------------------------FAEFH----------------GFSGR-----------------------------------------------------------------------------------------------------------DSSALFKWYQE--Q-------------------------------------------------------SPETLSNVKGYKKSISGFLTFI---------------------------------------------------P------NL----DGDFFPK------------PLDELRKEAPKKQMMTG---------------------------------------VTEYEGLMLASM-NP-------------------------------------------------------------------------------------------------------------------------------AFSPADVGLTLMPQGIYGKDV-------------------VSNPDEIQK------------------------------------------------------------------------------------------------------------------------------------------IFYEKY-VEGVDKSDEL-----------------------------------------------------------------AMRKKLCEA-----LG-D------------------------------EFFNVGVIQAAKNAAKH------------------------------------------GNEVYFYTF-------EYVNPDSFGMWDGMMPFK-------------A-AVHC---------TEL-RYLLGEGVYSKFEPTEED----------------------------------- 744
745 FSQKNATEDC--------------------LYLSIYA----------------------------PSIRKSHPLPVMVW----F-------Y---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------FQM-GP--------------S--VKFDATALAA-----MN----EVIVVV------P-N---YR-VG-------------IFGFLSLGHETECK----------------G---NMGLLD--QLES----------------------------------------------L-----------------------------K--WVKEN-----------------------------IEYFG---------------------GD------------------------------------------------------KNN----V-TI--F-G--ES-----------------AG-----------------------------G-ISVHM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-MMSPL-------S---------------A---------------GYFHKAISH-----------------------------------------------------------------------------------------S-GTANMP----GVYFSD------QQRIVTKL---------------------------LESL-----------------NIKET-----------------------------------------------------------------------------------------------------------DPSLVLHQLQNLPADQLVDYNAVQFRFG-------------WYPTFD---------NHFFKTSP-----EMATVAKV-----------------------------------------------------------------P-------------------------------FL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-------------------GCNSDEGGWLMALTTPNFISGLSKQEFSHYARILLR---KYDKTIDYNKALPVL---------------------------------------------------------------------------------------------IMR--Y-SRGLDVKDKM-----------------------------------------------------------------YYSNLYGRM-----MG-D------------------------------CIFVNR----IIQTSQANSDK--------------------------------------GVDTFLYFMSHPPLHKHGDGY--GPLIARLPDHI-------------G-TDHA---------DDI-PFTFGLP-FLPNSLKSG------------------------------------ 745
746 ----R-SEDC--------------------LYLDVYT----------------------------PSTSDSSSLPVMVW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LQN-GF--------------G--NIYHAHCLCA-----LY----DVVVVV------P-T---YR-VN-------------ICGFLTLGADTKWP----------------G---NIGMLD--QVAA----------------------------------------------L-----------------------------K--WTRDN-----------------------------VKGFG---------------------GD------------------------------------------------------PSN----V-TI--F-G--ES-----------------AG-----------------------------A-FSVGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VVSPM-------S---------------K---------------GLFHRAISH-----------------------------------------------------------------------------------------S-GTAHFP----VLLSRS------SKDALQSL---------------------------LEFL-----------------NIKET-----------------------------------------------------------------------------------------------------------KPEVIVEKLKQVPMQQLLEAQWKIQTEKISSFYFIQGLFHIFYSCVD---------NKFITDDPLN-IWKAKGTAPV-----------------------------------------------------------------P-------------------------------YM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-------------------GCNNSEGDGILVAIVTD--NDATEEKTLQFIQDSLQA--METPVRGFRKTSVSI---------------------------------------------------------------------------------------------VLQ-KY-ATGLD-NDKE-----------------------------------------------------------------KWMKMYGAL-----MR-D------------------------------LWFIVP----SIMQCNAHAAA--------------------------------------GRKTFLYYMTQQPRHNHTNQY--GAEIKNKPDHC-------------Q-CDHA---------DDI-LYTFGLPLFSKDQFKPEVEFSEED----------------------------- 746
747 ----NLQEDC--------------------LYLNVFT----------------------------NNLDAKANLPVLVW----L-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LSM-GS--------------A--VYYDAKTICS-----MQ----DVVVVI------P-N---YR-VN-------------VFGFFTAGKDTKWK----------------G---NMGLYD--QLKA----------------------------------------------L-----------------------------E--WVKHN-----------------------------VKSFG---------------------GN------------------------------------------------------PDN----V-TI--F-G--ES-----------------AG-----------------------------G-LSVGC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VLSPL-------S---------------R---------------GYFHRAISH-----------------------------------------------------------------------------------------S-GTATMPKGTETITKPESIAPVPY--------------------------------------------------------IVGC-----------------------------------------------------------------------------------------------------------NNTETAAKKYSVTQDSQREAVGKLLKEK-----YIQNY------SVDDKHRWSKTAGEMFAD------INSSNIAPV-----------------------------------------------------------------P-------------------------------YM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-------------------GCNNTEGFGIISGMIPEFESGSTKEGVMDFLKMILQ---YKTCTEKQLKNIAES---------------------------------------------------------------------------------------------LLK-NY-SKNYSAEDKL-----------------------------------------------------------------RWSKAAGEI-----LG-D------------------------------LWFAVP----SLLQANAHAGA--------------------------------------GHPTYFYYMTQISKFCHSKDHILSGDLKLKVDFC-------------E-CDHG---------DDL-TYTFGLP-YATTKLSSEVKFTKDE----------------------------- 747
748 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q----DVVVVI------P-N---YR-VN-------------VFGFFTAGKDTKWK----------------G---NMGFFD--QLKA----------------------------------------------L-----------------------------E--WVKHN-----------------------------IQVFG---------------------GN------------------------------------------------------PEN----V-TI--F-G--ES-----------------TG-----------------------------G-FSVGY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VLSPL-------S---------------R---------------GYFHRAISQ-----------------------------------------------------------------------------------------S-GTATMP----TMMKTE------YTNFRKCM---------------------------LEHL-----------------KITAT-----------------------------------------------------------------------------------------------------------NPDEIVAEMKKISADKIMEAQAEGFKTV-----TF-GA------SID---------GEFILEDALDGIRNSSNIAPV-----------------------------------------------------------------P-------------------------------YM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-------------------GCNNTEGFGIISGMIPEFESGSTKEGVMDFLKMILQ---YKTCTVSRNTYIFSS---------------------------------------------------------------------------------------------CLK--------CSNDKL-----------------------------------------------------------------RWSKAAGEI-----LG-D------------------------------LWFAVP----SLLQANAHAGA--------------------------------------GHPTYFYYMTQISKFCHSKDHILSGDLKLKVDFC-------------E-CDHG---------DDL-TYTFGLP-YATTKLSSE------------------------------------ 748
749 ----NLQEDC--------------------LYLNVFT----------------------------NNLDAKANLPVLVW----L-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------LSM-GS--------------A--VYYDAKTICS-----MQ----DVVVVI------P-N---YR-VN-------------VFGFFTAGKDTKWK----------------G---NMGLYD--QLKA----------------------------------------------L-----------------------------E--WVKHN-----------------------------VKSFG---------------------GN------------------------------------------------------PDN----V-TI--F-G--ES-----------------AG-----------------------------G-LSVGC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VLSPL-------S---------------R---------------GYFHRAISH-----------------------------------------------------------------------------------------S-GTATMP----TMMKTE------YTNFRKCM---------------------------LEHL-----------------KITAT-----------------------------------------------------------------------------------------------------------DPDEMVAALKKVSAEKILEAQGEAYKKV-----FPMGAFGL---TVD---------GEFILGEGTETITKPESIAPV-----------------------------------------------------------------P-------------------------------YI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-------------------GCNNTEVCGILSVMIPEFATGATEEGIEGYLKMLLQAEKFPSVTVGK----------------------------------------------------------------------------------------------------LLKEKY-IQNYSVDDKH-----------------------------------------------------------------RWSKTAGEM-----FA-D------------------------------MWFIIP----SFYI--NYTDA--------------------------------------GHPTYFYYMTQAAKVFHSKEYVLSGELKPKVDFC-------------E-CDHG---------DDL-IYTFGYP-HSTTKLAPVVKFTDEE----------------------------- 749
750 EDSHLVSEDC--------------------LHLNIYA----------P-----------FPVLL-----SSEK-PVMIW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FTS-GQ------GK----------STDGSRLSL-----KG----DVIVVT------I-N---YR-LN-------------VFGFFSM--------GNPN---------ARG---NFGLYD--QQLA----------------------------------------------I-----------------------------K--WVYEN-----------------------------IHAFG---------------------GD------------------------------------------------------PNK----I-TL--F-G--ES-----------------AG-----------------------------G-VSTTI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-GVIPS-------N---------------V---------------GLFKRVIGE-----------------------------------------------------------------------------------------S-GSVL---------ARRDYQT-----KTY------------------------------ETSK---------QII----KNIHC----------------------------------------------------------EKS----------------------------------------------SDTEILGCLRS--Q-------------------------------------------------------NASVLLQTWQQID-WKKPSKASYSM--TTSIG-----------------------------------------P------IT----DG--------------E--LI----PESPE-TA------------------------------------------LKNPKSSMYRQF-TS---------------------------------------------------------------------------------------------------------------------------VD--LL------------------V-------------------GTNTADSGLL-------Y----------F-----------------------------------NLKPYAQIFNINVTEGVPTRIVCDEMAPSIV---REIFSIKCPALAE------------------------------------AICKQY-SPKSPATLQ------------------------------------------------------------------VQSQMAADL-----YG-D------------------------------FLEDVP----TIKSLNYH-AQS-------------------------------------VKSTFQYLF-------SHRPNWEIIG-------DRPPWL-------VG-ANHA---------SEI-PFVFG------LKSFYPPTIP-------------------------------- 750
751 --SANYSEDC--------------------LYLNVFT----------PKYKQRTQGLIFS------------DLPVLVF----I-------H---------------------------------------------------------G--------------------G----R-----------------------------------------------------------------------------YWT-GS--------------A--ADFAADKMAS-----VG----NAVVVV------I-Q---YR-LN-------------IFGFQPY---------DSN-----------T---NIGLLD--QQMA----------------------------------------------L-----------------------------K--WVQDN-----------------------------VRAFG---------------------GD------------------------------------------------------ANK----V-TI--F-G--ES-----------------AG-----------------------------G-SSVLY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLQPT-------S---------------Y---------------SLYDRAILE-----------------------------------------------------------------------------------------S-AWQF---------VIPTVAT---------A---------------------------RVKSN---------DYL----IKKNC----------------------------------------------------------NRTKTDGTQ----------------------------------------DLTAILTCLQS--L-------------------------------------------------------DPLTLTPTTGQSDFFL---------------------------------------------------------P------MI----DG--------------K--FI----TQLPL-KS------------------------------------------IKQRQ------Y-NQ--------------------------------------------------------------------------------------------------------------------------NAK--II------------------I-------------------GHNYDEGYF---------------------------------------MAYSRLGFKTINESVTDATY----------------------YSSLTKYLNVYFTPEQTQ---------------------------------------TIVDLY-----------------------------------------------------EPAKAAL----------------GNWLAASEF-----FG-D------------------------------YYITCG----SILAAQYFNAY--------------------------------------DTDFKTYIF-------NYSSPNYPAS---------EAYL--------A-ASHG---------NEL-AYIFFNP---------------------------------------------- 751
752 SIWYPQSEAC--------------------LTLNVIR----------D-----------SSVDE------TSSLPVGVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FYQ-GS------GA------D--QRYNTSAIVANAQR-IG---KPFIAVT------I-N---YR-LS-------------TWGFLNSAEIREAGATNL------------------GLRD--QRLA----------------------------------------------L-----------------------------H--WIQEN-----------------------------IASFG---------------------GD------------------------------------------------------PKK----V-TI--W-G--ES-----------------AG-----------------------------G-MSVGN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-LIAYGGR-----D---------------D---------------GLFRAGIME-----------------------------------------------------------------------------------------S-GG------------------------SIAA---------------------------SPGNTTA-YQSQYDDIV----AKAGC----------------------------------------------------------ATASDTLQ------------------------------------------------CLR---EVPFESL---------------------------------------------------NAIFNTTTGDP-AYS--FG----------------------------------------------------P------TV----DG--------------D--FL----REWGS-VQ------------------------------------------LDKGEFV-------K---------------------------------------------------------------------------------------------------------------------------VP---I-----------------IS-------------------GTNTDEGASF-------GP-------TGI------NTTQQFY------------------------------------------------NYLTGGASGYRYPPAIAKE----ILDLYPDDPSKGIP---EFLGNQRIPS-------K-GWQW----------------------------------------------------------------------------R---RTSAY-----AG-D------------------------------YSMHAN----RRRQTEVWAEH--------------------------------------GIPAYAYRFNMR------SGNADWIG---------------------G-AQHF---------EEV-AFVFKNF---------------------------------------------- 752
753 -TFYNQSEDC--------------------LYLNIVR----------P-----------AGYDQ-------EKLPVGFW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FSN-GG------GG------D--QRYNLSFIVKQSVK-IG---KPIIGVS------I-N---YR-LN-------------LWGFLHSNEVVGEGITNL------------------GLRD--QRLA----------------------------------------------L-----------------------------Y--WVQEN-----------------------------IATFG---------------------GD------------------------------------------------------PGK----V-TI--F-G--ES-----------------AG-----------------------------A-ASVGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-V-----------------------------------------------ATTSS-----------------------------------------------------------------------------------------S-APQY-------------------YSLVIPY---------------------------S-------TEPKMERSA----RKPPS----------------------------------------------------------RRSYPRLDAP---------------------------------------RPGTGSNVSR---EVSFLTL---------------------------------------------------NATYDSI-------NGSFA----------------------------------------------------P------TI----DG--------------D--FI----RTYGS-KQ------------------------------------------LLDGQFV-------R---------------------------------------------------------------------------------------------------------------------------VP---I-----------------IT-------------------GTNSDEGASM-------SP-------TGI------NTTEDFK------------------------------------------------ATLSS---------FLPVSFQDAILKAYPDDLSVNVIAS---LGDQRPVA-------PYGAQF----------------------------------------------------------------------------R---RSASF-----WG-D------------------------------YYFIAS----RRQTAKTWAAH--------------------------------------GIPAYAYRFNAI------PAGVPPEV---------------------G-VGHY---------KEI-GFMFNNLEGVGYRPDIKPFEGK------------------------------- 753
754 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VS------I-A---YR-LG-------------PYGFFNGNEVAAEKALNL------------------GLKD--QRLA----------------------------------------------L-----------------------------H--WIQEN-----------------------------IAGFG---------------------GD------------------------------------------------------PRK----L-TI--Y-G--QS-----------------AG-----------------------------A-EGVGY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LRAFNGR-----D---------------D---------------GLFRAAIMQ-----------------------------------------------------------------------------------------S-GP------------------------VIPQ---------------------------GPLSLTASYQYRYEGVV----AEEGC----------------------------------------------------------SHADHKLD------------------------------------------------CLR---ALPFAVL---------------------------------------------------NNVLNSS-----AYNTGWG----------------------------------------------------P------TV----DG--------------D--FV----ARYTS-EQ------------------------------------------VDDGSFA-------R---------------------------------------------------------------------------------------------------------------------------VP---I-----------------IA-------------------GTTTDEGSTQ-------SP-------KPV------NTTEELR------------------------------------------------GWMNTTSS---YQLALPKSSINALLTLYPNTTTFGIPSSAELGGNVTLPQ-------PYGAAF----------------------------------------------------------------------------R---RSAAY-----FG-D------------------------------QVFTAS----RRKTCQAWAAH--------------------------------------ALSAYCYRFNTK------PTTTSWVE---------------------G-VAHF---------SDV-AFVFNNLNGQGY--DVNPFAMGN------------------------------ 754
755 ---TTKTEDC--------------------LVLNIYA----------P-----------ASVNLDSTNNMNELLPVMFW----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FFA-GS------GT------N--PGYDGGWLTN-----KT----NTVVVN------I-N---YR-LD-------------ALGFLVF--------EEGG-EKF-----D-G---NQGFKD--QQLA----------------------------------------------L-----------------------------K--WVRDN-----------------------------IAKFG---------------------GD------------------------------------------------------KNK----V-TI--F-G--NS-----------------AG-----------------------------A-QSVML---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-VLSQE-------S---------------D---------------PLFHRAIMQ-----------------------------------------------------------------------------------------S-NPA--------------------------V---------------------------FYYYTTDEAKVVTEELL----DVLNC-----------------------------------------------------------TTNK-------------------------------------------------LDCLMS--T-------------------------------------------------------EAHTLVNARAKVM-AKAALRRNIFDGVEPYR------------------------------------------P------VT----DG--------------I--EF----IGQPL-DQ------------------------------------------FQSGN------W-QK--------------------------------------------------------------------------------------------------------------------------NKA--LI------------------V-------------------GSNTEEL-E------------------------------------------------------------------------------------------------------------------------------------------FINVVF-RNRTVRKNIFETVNNFVLGD-----Y---YGPIVS----ERYMQLAGETPEVQYDY--T----------------A---ILAQE-----IG-D------------------------------MFFVCP----SRALARLASRS-----SPA------------------------------SDTVYLYSN-------SH-PADL---------GACTSEA----STCGH-AYHG---------SEP-RYVFNT--VPNATADD------------------------------------- 755
756 ----------------------------------IDV----------P-----------SAFNLADT-KPSNLLPVLFY----I-------H---------------------------------------------------------G--------------------G----F-----------------------------------------------------------------------------FFA-DS------GT------S--YLEDGRWLCN-----AT----NTVVVT------I-N---YR-LG-------------ALGFLAY--------KQGG-VEL-----G-G---NQGLKD--QQFA----------------------------------------------M-----------------------------R--WVQEN-----------------------------IHKFG---------------------GD------------------------------------------------------KDK----I-TL--F-G--NS-----------------AG-----------------------------A-QAIMF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LVSST-------S---------------E---------------PLFHQAIMQ-----------------------------------------------------------------------------------------S-NPS--------------------------V---------------------------FKYSTTVDSYRVTEYLM----EAINC-----------------------------------------------------------TKN--------------------------------------------------LTCLME--T-------------------------------------------------------DPTTLVNALGQVR-KSALVNAEIFNAIEPYR------------------------------------------P------VI----DG--------------H--EF----TDQPL-QL------------------------------------------IQEGK------W-PE---------------------------------------------------------------------------------------------------------------------------KN--FI------------------I-------------------GTNTEELYP------------------------------------------------------------------------------------------------------------------------------------------YVVAIF-NNTNIGKVEFEDFNKYMLGK-----E---IGEMVN----TKYEQLVSNPSQ-TTDY--T----------------Q---VLGVE-----LT-D------------------------------MFFTCP----SRALARFASNS-----SR-------------------------------GKEIYLYDN-------SY-PNGG---------PGCYAVRQNLDGVCGT-SFHG---------SEV-VFVFGSGPSFGMTFTDNDT---------------------------------- 756
757 LTPFPKSEDC--------------------LQLNVFV----------P-----------G-VPS---PSS--KKTVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------YIA-GS------SL------I----YDGSNIAH-----QG----DVIVVT------I-N---YR-LG-------------IFGFLSL--------NDPV---G-----K-G---NYGLWD--QILA----------------------------------------------L-----------------------------Q--WVQRN-----------------------------IAAFG---------------------GD------------------------------------------------------PSS----V-TI--F-G--ES-----------------AG-----------------------------G-FSVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-SLIPS-------N---------------R---------------GLFHRVISQ-----------------------------------------------------------------------------------------S-GVAA---------SRWAFG-------S--S---------------------------EPATR---------SVG----DMLGC----------------------------------------------------------SR--QL-------------------------------------------SSQLYIDCLR---K------V------------------------------------------------NASSLNDY---------TIAYLQRDPSTIRQL----------LEFT---------------------------P------YI----DD--------------E--LF----HHMPS-KI------------------------------------------LSNSSLLEHEFL-IS---------------------------------------------------------------------------------------------------------------------------LD--LI------------------S-------------------GTVRTEGSL------------------LA------GVI-------NQPAVQEKFNIN-ITAGISTEFM----------------------CDNFTKTLVSEFFDGNNRVKD------------------------------------LICEKY------------------------------------------------TV--QNNMTEQG----------------R---RMLDI-----FT-D------------------------------FVFVAP----SFIQLQSH-SLQ-----NV------------------------------RSKSFQYVL---------ERKKVTLDGTLSYY---PPWY-------DP-PGHA---------EDL-YYLFP-------Q-SIGLTSPVD------------------------------ 757
758 --MFRMDVDC--------------------LILNIYT----------P-----------V-NVT-----G--KLPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------YTA-GG------AI------S----YDGSALAN-----VG----NVVVVT------I-N---YR-LG-------------LEGFLSF--------GDRF---L-----K-G---NYGIWD--QILA----------------------------------------------L-----------------------------E--WVKNN-----------------------------IEDYG---------------------GN------------------------------------------------------PEE----V-TI--F-G--ES-----------------AG-----------------------------G-MSVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-SLIPR-------N---------------K---------------GLFKRAIMQ-----------------------------------------------------------------------------------------S-GVAN---------SVFAFQ------HD--P---------------------------ADSKR---------AIA----GQFGC----------------------------------------------------------PY-NQV-------------------------------------------NPRASFECMQ---Q------V------------------------------------------------TMSTLVNA---------TGNVISNADSTL-------------LPVG---------------------------P------VV----DE--------------E--LF----KRTIP-EM------------------------------------------LADKGSEELDFF-RT---------------------------------------------------------------------------------------------------------------------------ID--IM------------------V-------------------GTADSEGSL------------------LL------RMG---------KAVQSTYGFNIITDGIPYHVF----------------------CNVFIQGIVTETYKGNDKVSE------------------------------------AMCRRY------------------------------------------------G--RADDQSETS----------------R---QAVNM-----YT-D------------------------------MFFLSP----AVEILLVH-ASD-----NK------------------------------IAKSYQFVF---------SEWS--LPFIFDAEEFPP-WY-------QG-AGHA---------TDL-IYLFFLEFMPILNPNITIDASD------------------------------- 758
759 FESFEMSEDC--------------------LQLNIYV----------P-----------N-SVN---ISSTVQTPVMVF----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FTG-GG------AD------L----YDSSELSR-----QG----GVIIVT------I-Q---YR-LG-------------IFGFFSL--------GNEE---A-----S-G---NYGLWD--QMLA----------------------------------------------L-----------------------------K--WVNQN-----------------------------IGSFG---------------------GN------------------------------------------------------AGA----V-TV--F-G--QS-----------------AG-----------------------------G-VSSLF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-SLIPE-------N---------------K---------------NVFHRVIVQ-----------------------------------------------------------------------------------------S-G-------------NLLVS-------N--S---------------------------TQASY---------DIG----ELLGC----------------------------------------------------------SN--NI-------------------------------------------GTSTFVACLR---------------------------------------------------------------------------------NKDPNTILTTSSTYRFTGAGLPFT---------------------------P------NV----DG--------------E--LL----KKTPE-SL------------------------------------------LNDFSSEEYKFF-SS---------------------------------------------------------------------------------------------------------------------------LD--FM------------------T-------------------GTIKTDGNI------------------FL------VSL-------SE-SIQNALGIN-LTAGVSTEEF----------------------CNTLVPAILNVPYKNNTLVSK------------------------------------RLCEEY------------------------------------------------RV--QNNVSEQS----------------R---QMLQF-----VT-D------------------------------YTFAYP----AFGGLRAH-SSQ-----NL------------------------------ASNTYQYVF-----ELEAERSRL-----LQRP---PVWY-------IG-PGHG---------DEM-FYLFP---------NIHLTDVQ------------------------------- 759
760 TKYPGISEDC--------------------LKLNIYV----------P-----------T-GVV---SSN--NKPVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FVY-GS------GG------D----YDGSSLSL-----NG----DVIVVT------M-N---YR-LG-------------IFGFLQS--------KNYK---A-----K-G---NAGLWD--QILA----------------------------------------------L-----------------------------N--WVRYN-----------------------------IKDYG---------------------GN------------------------------------------------------PKD----V-TI--F-G--ES-----------------SG-----------------------------G-MSVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-SLIPS-------N---------------R---------------GLFHRVIAQ-----------------------------------------------------------------------------------------S-GVAN---------SFLALP------NT--A---------------------------AQHTI---------EIA----EMVGC----------------------------------------------------------SHVRST-------------------------------------------NEQNFIECLQ---S------V------------------------------------------------DAANLVNA---------TDYLFVGNELKFMAD----------LPFA---------------------------P------VI----DG--------------E--LF----HKNPA-IL------------------------------------------LKDRTSSEFTFF-QS---------------------------------------------------------------------------------------------------------------------------LD--LM------------------V-------------------GTCDNDGSE------------------AL------GLS-------S--SFQSQLNVD-FSKGLPTRVF----------------------CESIITEFSKTLYNNSRDVSA------------------------------------AISEKY------------------------------------------------SV--TNDNQEQA----------------R---MFLNM-----YG-D------------------------------AGFVAP----ATLVLKQH-SNS-----LQ------------------------------GSTTYQFVF------------SEELPFLNPDA---PSWY-------KG-SAHA---------SDI-YFMFYYEDMKKES-NFSKET--------------------------------- 760
761 TKYPGLTEDC--------------------LKLNIYV----------P-----------H-EIS---SSN--NKAVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FAF-GS------GG------T----YDGSPLSL-----IG----DVIVVT------I-N---YR-LG-------------IFGFLQS--------NNYK---A-----K-G---NAGLWD--QILA----------------------------------------------L-----------------------------N--WVRYN-----------------------------IKDYG---------------------GN------------------------------------------------------PKD----V-TI--F-G--ES-----------------AG-----------------------------G-FSVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-SLIPS-------N---------------R---------------GLFHRVIAQ-----------------------------------------------------------------------------------------S-GVAN---------SHLALP------NK--S---------------------------AKHTI---------EIG----EMVGC----------------------------------------------------------SQDRIM-------------------------------------------NEQNFIDCLQ---S------V------------------------------------------------DAMDLVNA---------SDQLFLGLGFDSMVD----------IPFA---------------------------P------AI----DG--------------E--LF----HKTPN-IL------------------------------------------LKDRTSSEFNFF-QS---------------------------------------------------------------------------------------------------------------------------LD--MM------------------I-------------------GTCDNDGSL------------------AL------GLS-------P--SFQSKLNLN-FSEGLPTREF----------------------CESIITVFSKALYNNSRDVSA------------------------------------AICEKY------------------------------------------------SV--TNDNEEQA----------------R---MFLHM-----YA-D------------------------------AGFVAP----ATLALKQH-SNS-----VQ------------------------------GSTTYQFVF------------SEELPLLNPNA---PSWY-------RG-SAHA---------SDI-FFMFFYEEMKRVS-NFSKET--------------------------------- 761
762 FVKYGMNEDC--------------------LHLDIYA----------P-----------P-GLS---RFS--IKSVMVW----V-------H---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------YTV-GS------AS------F----YDGSMLAK-----TG----HVVVVT------I-N---YR-LG-------------ILGFLAL--------KNST---T-----K-G---NYGLWD--QMMA----------------------------------------------L-----------------------------Q--WIKDN-----------------------------IDDYG---------------------GD------------------------------------------------------PNS----I-TI--F-G--QS-----------------AG-----------------------------G-FSVGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-ALIPQ-------N---------------K---------------GLFHRVIMQ-----------------------------------------------------------------------------------------S-GVPN---------SSLKVTR---PGYD--T---------------------------YTTSD---------TIS----THL-C----------------------------------------------------------PF-FRQ-------------------------------------------DLAMRVICLR---Y------L------------------------------------------------SSPTLTRP---------Y---------AY-------------LSFA---------------------------P------VV----DN--------------E--LF----EQTPE-EI------------------------------------------LKDGNSSAFEFF-MS---------------------------------------------------------------------------------------------------------------------------LD--IV------------------V-------------------TNCDVDGSV------------------LF------PTL---------KVLEISYKFD---SSTPPELV----------------------WAYGPESMLESYYGTNKRIIK------------------------------------EVSNFY------------------------------------------------GFTRDLDFKDQS----------------K---KWTAF-----YT-D------------------------------LFFMAP----SMEIADVH-Y-------NR------------------------------VSSTFRLVL---------TRKSPVYPGLMYNESSPPGWF-------HG-AAHS---------DDV-VFLFLIETLQELDPNTTVT---------------------------------- 762
763 TIWYGTSEDC--------------------LQLNIYV----------P-----------F-ATS---PSI--KKSVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------YFF-GT------AS------F----YDGSMIAV-----EG----GVIVVT------V-N---YR-LG-------------FFGFLSL--------GDET---T-----K-G---NYGLLD--QIQA----------------------------------------------L-----------------------------K--WVKEN-----------------------------IADYG---------------------GN------------------------------------------------------PNN----I-TI--F-G--ES-----------------AG-----------------------------G-FSVGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-SLIPQ-------N---------------K---------------GLFRRAIHE-----------------------------------------------------------------------------------------S-GTAN---------SLLTLGS---PVEA--T---------------------------IETAK---------ALG----CQT-----------------------------------------------------------------T-------------------------------------------NSTILMNCLL---EKPADAIL------------------------------------------------TQSTMVSE---------R--LCNLDRMNC-------------LYFG---------------------------P------VI----DG--------------D--LL----VRTPV-EL------------------------------------------MSNKTTEAYKFF-QS---------------------------------------------------------------------------------------------------------------------------LD--LM------------------V-------------------GNCRMEGSL------------------YL------SMLGNNVQYQKDKNINVSIGLS-------HQYL----------------------CDVMSPNIANFYFKNNRKVSQ------------------------------------AICQEY------------------------------------------------Y--VADNATLQS----------------R---AVLDV-----YS-D------------------------------LFFISD----ATYTLNAH-V-------NS------------------------------ESSTYQFMY---------NQ---VLPFKLVPE---PTWY-------EG-PSHA---------EEL-YYLFTMEYFDRILPNVTISDSD------------------------------- 763
764 IDKLENDEDC--------------------LYLNVYV----------P-----------G-KIS---KDK--DLSVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FIT-GG------AS------Q----YKPQKIVV-----GG----GVIVVT------I-N---YR-LG-------------LLGFLTL--------HDPL---V-----P-G---NYGLWD--QIEA----------------------------------------------L-----------------------------R--WIQDN-----------------------------IAAFG---------------------GN------------------------------------------------------PKS----V-TI--F-G--ES-----------------AG-----------------------------G-MSVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-TLIPS-------N---------------E---------------GLFQRAISQ-----------------------------------------------------------------------------------------S-GVVS---------FYALARR-----KA--E---------------------------KHTNE---------LLL----KKTNC-----------------------------------------------------------D--RG-------------------------------------------NLSETLKCLR---E------L------------------------------------------------PVDNITNS---------VGMADFMNPSNITVED---------GSMV---------------------------P------TV----DG--------------D--LI----KEDLA-YP-------------------------------------------KSWDSEVYNFF-RS---------------------------------------------------------------------------------------------------------------------------ID--FM------------------S-------------------GTLDGEGIM------------------GM--------------FIIHPSLIEKMNIN-VSESVPKTIL----------------------CDYMAAMFVDTAAGNIPSLTQ------------------------------------EICDYY-------------------------------------------------T--AEDVDEQS----------------N---KVLEF-----IG-D------------------------------SWFIVP----SNIMLSIH-ANS-----NE------------------------------KRNTFQYLV------------TRPTPFPLLPFE-IPSWI-------KG-AGHG---------EEL-HLLFIMSH-EQVSEEKLKTIDLNA----------------------------- 764
765 -----NDEDC--------------------LYLNVYV----------P-----------G-KIS---KEK--QLSVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FVL-GG------AS------Q----YKPQKIVL-----GG----DVIVVT------I-N---YR-LG-------------LFGFLTL--------HDPL---V-----P-G---NYGLWD--QIEA----------------------------------------------F-----------------------------R--WIKKN-----------------------------IAAFG---------------------GN------------------------------------------------------SKS----V-TI--F-G--QS-----------------AG-----------------------------G-MSVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-TLIPS-------N---------------E---------------GLFQRAISQ-----------------------------------------------------------------------------------------S-GAVP---------FYAIAGR-----KA--E---------------------------EQINT---------ILL----KNTNC-----------------------------------------------------------K--RE-------------------------------------------SISETLSCLQ---D------L------------------------------------------------PAENITEA---------ITFTEFVNPDNITAQI---------GSMT---------------------------P------TI----DG--------------T--LI----KTDLS-YS-------------------------------------------KYWDSEVYRFF-RS---------------------------------------------------------------------------------------------------------------------------ID--FM------------------S-------------------GTLDGEGIM------------------GF--------------FNVPPGAFEKLNVN-VAEGVPKSVL----------------------CEVIAPMYVEMRVGNIHSLTQ------------------------------------EICDYY-------------------------------------------------T--AEGVDEQS----------------N---KVFEF-----YT-D------------------------------SWFIVP----SNIMLSMH-AKK-----NE------------------------------KTKTFQYFI------------IKTSPFSLLPTELLPSWF-------KG-ARHG---------DEL-PLLFNVSR-DHISEEK------------------------------------- 765
766 ---LENDEDC--------------------LYLNVYV----------P-----------G-KIS---KDN--QLSVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FMF-GG------AS------Q----YKPQKIVL-----GG----DVIVVT------I-N---YR-LG-------------LLGFLNL--------HDPL---V-----P-G---NYGLWD--QIEA----------------------------------------------L-----------------------------R--WIQNN-----------------------------IAAFG---------------------GN------------------------------------------------------PHS----V-TI--F-G--QS-----------------AG-----------------------------G-ISASI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-ALIPS-------N---------------E---------------GLFQRAISQ-----------------------------------------------------------------------------------------S-GVAS---------FFSFPKR-----KA--E---------------------------ERTNA---------ILL----NKTKC-----------------------------------------------------------N--RE-------------------------------------------NTEETLKCLR---K------L------------------------------------------------PVDNITEA---------IGMTEFSKPLNVSFEM---------GSFV---------------------------P------SV----DG--------------E--LV----KENLA-YP-------------------------------------------KSWDNEIYNFF-RS---------------------------------------------------------------------------------------------------------------------------ID--FM------------------S-------------------GTLDGEGGS------------------AY--------------SMFPSELLEKMHVN-VTESVPKTVL----------------------CEVLAPVFVETVAGNKPSLTQ------------------------------------EICDYY-------------------------------------------------T--TEDIDEQS----------------N---KVFEF-----LG-D------------------------------AWAIAP----SNFLLSIH-AKN-----NN------------------------------MVKTFQYLV------------TKPTPFPLVPMD-PPAWL-------KG-AGHG---------DEL-HLLFEMSH-DGMSEKK------------------------------------- 766
767 ----QNDEDC--------------------LYLNVYV----------P-----------G-KIS---KDN--QLSVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FVF-GG------AS------Q----YKPQKIVL-----GG----NVIVVT------I-N---YR-LG-------------LFGFLNL--------HDPL---A-----P-G---NYGLWD--QVEA----------------------------------------------L-----------------------------R--WIQKN-----------------------------IAAFG---------------------GN------------------------------------------------------PKS----I-TI--F-G--QS-----------------AG-----------------------------G-MSVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-ALIHS-------N---------------E---------------GLFQRAISQ-----------------------------------------------------------------------------------------S-GAVS---------FFAIAGK-----KA--E---------------------------GKTNE---------VLL----KNTNC-----------------------------------------------------------K--RE-------------------------------------------RVSETLSCLQ---N------L------------------------------------------------PAENITEA---------VTLTEFVNPDNITAEI---------GSMT---------------------------P------TV----DG--------------Y--LI----KKDLA-YP-------------------------------------------ENWDDRIYQLF-RS---------------------------------------------------------------------------------------------------------------------------ID--FM------------------S-------------------GTTDGEGNV------------------GF--------------FNIPQNVLTKLNVS-ATEAVPKSVL----------------------CQVLAPMFVQTGAGNIPSLTQ------------------------------------EICDYY-------------------------------------------------T--AEDVDEQS----------------N---KVFEF-----YG-D------------------------------SWFIAP----SNIMLSIH-ANN-----KE------------------------------NTKTFQYLF------------TQPSPFPLLPRELLPSWL-------KG-AGHG---------DEL-HLLFIISR-DHIP---------------------------------------- 767
768 FNFSETNEDC--------------------LYLDIYV----------P-----------G-KIS---LER--NLSVIVW----I-------F---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FII-GA------AN------Q----YRPQPMVL-----KG----DVIVVT------I-N---YR-LG-------------LLGFFTM--------HDPL---L-----S-G---NYGIMD--QIEA----------------------------------------------L-----------------------------R--WIHNN-----------------------------IASFG---------------------GN------------------------------------------------------PNS----V-TI--F-G--ES-----------------AG-----------------------------G-MSISL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-TLIPS-------N---------------E---------------GLFQRAISQ-----------------------------------------------------------------------------------------S-GVVS---------TVTFAKK-----EW--E---------------------------IRTKD---------IFL----ERTNC----------------------------------------------------------SD--KR-------------------------------------------DAAETLDCLQ---K------L------------------------------------------------PVENITNA---------IMLPDIMDFQNVSYQA---------GGLY---------------------------P------SV----DG--------------K--LI----DEHLA-YP-------------------------------------------KSPEDKSYTFF-RS---------------------------------------------------------------------------------------------------------------------------LD--FM------------------S-------------------GTLDGEGNM------------------LY--------------MGLTPDVQKKYNFS-VTEKIPKSVL----------------------CEMTAPVFVNNAVGNVPELAQ------------------------------------EICDFY------------------------------------------------TT--AESIDAQS----------------N---KVCEF-----HG-D------------------------------STFIVP----SNLMLSTH-AKD-----NP------------------------------QANTYQFLI------------TKTRPFPIGGD--PPSWF-------KG-AGHA---------DDL-RFFFNFSDIFQIPDE-------------------------------------- 768
769 ----EYTEDC--------------------LYLNIYV----------P-----------G-DVS---RDR--RLSVMLF----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FVM-GS------AG------E----YNGQRLAA-----QG----DVIVVT------I-N---YR-LG-------------LFGFLNL--------LDPI---A-----N-G---NYALWD--QMAA----------------------------------------------L-----------------------------R--WVHEN-----------------------------IEAFG---------------------GN------------------------------------------------------PDS----V-TI--F-G--ES-----------------SG-----------------------------G-MCVHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-TLIPA-------N---------------I---------------GMFQRAISM-----------------------------------------------------------------------------------------S-GVVN---------KQIIMND-----ND--L---------------------------NKVLN---------MIS----DKTDC----------------------------------------------------------KQ--EN-------------------------------------------KAEL-LMCLQ---K------L------------------------------------------------TPTEILGI---------VNIYEFMTPDNYTEEM----------LIG---------------------------P------SI----DG--------------E--LI----NGQLY-HT------------------------------------------MHDRSSPEATFF-RS---------------------------------------------------------------------------------------------------------------------------LD--FM------------------S-------------------GTTNAEGSV------------------LF--------------YSLMPDFQETFNFS-VEDGITRRVL----------------------CEAIIPGLIQGLYGNRPDLSQ------------------------------------RLCEFY------------------------------------------------TS--DKGNDDQS----------------N---RALAF-----YG-D------------------------------LTMVAP----STSALIAH-GRK-----NT------------------------------AHRTYNYIL------------SAPSPVPFEPP--PPAWF-------SG-AGHA---------DDL-YLLFDM----PIL---------------------------------------- 769
770 ---DEQSEDC--------------------LQLNVWT----------------------------PSLDPSANKAVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FAG-GW--------------S--SMYEGVALAA-----YE----DVVFVS------I-N---YR-CG-------------LLGFLST--------GDEV---------IPG---NYGLLD--QMEA----------------------------------------------L-----------------------------R--WISKY-----------------------------IRKFG---------------------GN------------------------------------------------------PDN----V-TI--L-G--QS-----------------AG-----------------------------G-ISCAM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LVSEA-------A---------------Q---------------GLFHRAICQ-----------------------------------------------------------------------------------------S-GTCLIPGMTWSQDTAKGNTLNAMKKL-------------------------------------------------------GC--------------------------------------------------------------------------------------------------------ESENSQDILKFLQEISIEEIT-------SKLTPA--DIFR---------------------------------------------------------------------------------------------------------P------CV----DN-----------------KV------------------------------------------------------VASGNIEAFRPSSDI------------------------------------------------------------------------------------------------------------------------------PLM------------------V-------------------GCNNGEGALMVHLFCGFKVPNDEVFNNVLRIMAAMGF-------PSDVTD-------------------------------------------------------------------------------------------------AILEEY-KTEYFEGDSEE----------------------------------------------------------------DRLRGLTEL-----IG-D------------------------------FVFVYP----SMSAAEKYC--E-------------------------------------GSNTYLYYL-------D-ITPSYSPY---------PEWV--------G-ADHA---------ADV-SFVQGHML--FDYNHLPSWTFNDE----------------------------- 770
771 VPYKSVSEDC--------------------LQLNIYV----------P-----------S-NMT---REV--KRSVMVY----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------YMA-GS------AI------D----EDGSKFAS-----FG----NVILVT------I-N---YR-LG-------------IFGFPSM--------QNPN---V-----D-E---NVGIWD--QMLA----------------------------------------------L-----------------------------E--WIKNN-----------------------------IDDYG---------------------GN------------------------------------------------------SSD----V-TI--F-G--QS-----------------AG-----------------------------S-FSVNL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-MMIPR-------N---------------K---------------GLFHRAILQ-----------------------------------------------------------------------------------------S-GTAN---------SLIAF-------KR--S---------------------------SDLGH---------RIG----MDAGC-------------------------------------------------------------RDQ-------------------------------------------DPRMFLKCIQ---N------L------------------------------------------------DAGSLVNS---------TLDYSSNLGINVLTE----------IVFS---------------------------P------VL----DK--------------D--LF----QKTPI-EI------------------------------------------IHDKSSAEFQFF-ES---------------------------------------------------------------------------------------------------------------------------ID--MI------------------V-------------------GNCDEEGGY------------------VA------EYA-------A--LFEKQYNFS-RKDGIPRRFL----------------------CDGVIPSIVELYYKNSSSISE------------------------------------TICREY------------------------------------------------S---SNDKDTQS----------------M---NAAHL-----LS-D------------------------------FPFISS----AVSALQAH-SFN------Q------------------------------KSSTYQYIF------------SEDIRPFYTNM---PKWY-------HG-AVHG---------TEL-AFMFVAKDMYP-T-NFTLSP--------------------------------- 771
772 EVFNSASEDC--------------------LQLNIYV----------P-----------S-NMT---REV--KRSVMVF----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------YMA-GS------AI------D----EDGSKFAA-----FG----NVILVT------I-N---YR-LG-------------IFGFPSM--------QNPN---V-----D-E---NVGIWD--QMLA----------------------------------------------L-----------------------------K--WIKNN-----------------------------IDDYG---------------------GN------------------------------------------------------SSD----V-TI--F-G--QS-----------------AG-----------------------------G-FSVNL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-MMIPR-------N---------------K---------------GLFHRAILQ-----------------------------------------------------------------------------------------S-GTAN---------SLVAF-------KR--S---------------------------SDLGR---------RIG----TNAGC-------------------------------------------------------------RDQ-------------------------------------------DPRMFVKCIQ---N------L------------------------------------------------DAGSLVNS---------TLNHSSTLGINVLTE----------IVFS---------------------------P------IL----DN--------------D--LF----LRTPM-EI------------------------------------------IHDKFSAEFQFF-ES---------------------------------------------------------------------------------------------------------------------------TD--MI------------------A-------------------GNCDEEGGY------------------IA------QYA-------T--FFEKQYNFS-VVDGIPKRFL----------------------CDGVIPSIVELYYKNSSSISE------------------------------------TICEEY------------------------------------------------S---SNDKTTQS----------------L---NAAHL-----LS-D------------------------------FVFISS----AVSALQAH-SFN------Q------------------------------KSSTYQYIF------------SEDIRPFYTNM---PKWY-------HG-AVHG---------TEL-AFMFVAKDMYP-T-NFTLSQ--------------------------------- 772
773 LPNDRTEEDC--------------------LLLNVYV----------P-----------E-TAT---VNNS--LAVMVW----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FVV-GQ------GK----------IYNAVPLTV-----YG----NIIVVT------I-N---YR-LG-------------ILGSLTT--------GDEL---------AKG---NYAFKD--QQLA----------------------------------------------L-----------------------------R--WIKDN-----------------------------IGNFH---------------------GN------------------------------------------------------PNQ----I-TI--A-G--ES-----------------AG-----------------------------A-TSVMY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-MLSPS-------N---------------E---------------GLFQRGIAM-----------------------------------------------------------------------------------------S-TYFT---------PQSRPHHPPQAAEFYIR------------------------------VA----------------SIVGC----------------------------------------------------------YNSTVGDVGAQPPPPP---------------------------------NSEAILQCLRA--V-------------------------------------------------------SADDLISAALSIP-LLLSKVPYG--------------------------------------------------V------VI----DD--------------E--YF----PHSVR-TM------------------------------------------IEYSD------L-NK---------------------------------------------------------------------------------------------------------------------------YD--LM------------------I-------------------GTVDQEGLV----------------------------------------FAINIGPSIAEGL-SLETY----------------------KVLLQDL-SASYTSGVPEAAS------------------------------------SITQQY----------------------------------------TDW-----DNVDDKNMNRLN--------------------GYINA-----AG-D------------------------------IAFCLP----SIYFANRHATDS-----DG------------------------------TKSTYYYDF----------KTSVPMSFYGDIATT---------------AGHG---------DEL-GYLF------------YDEDSQLYQSTPY------------------------ 773
774 ------DEDC--------------------LYLNIYT----------P------------------SLDLSAKLPVMVW----I-------H---------------------------------------------------------G--------------------G----------------------------------------------------------------------------------YMMFSS------AA------E--VGYHPHEKTV-----QQ---TGMVYVT------F-N---YR-LN-------------AFGFLALNLLSERSITNTS-----------G---NYGFMD--QILV----------------------------------------------L-----------------------------E--WVQRN-----------------------------IRYFG---------------------GD------------------------------------------------------PDL----V-TI--F-G--QS-----------------SG-----------------------------G-TSVWA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-MVSPL-------A---------------K---------------GLFHRAWMS-----------------------------------------------------------------------------------------S-SSSVFNATLEQAEKDNLVFL----------------------------------------------------------HRSNC---------------------------------------------------------------------------------------------------------SD-----AECLYS--L-------------------------------------------------------TPSQVMDAV----------------------------------------------------------------PIDIYPYWVPADACDLPTKGLLYGPICIVDGLVV----PNAPL-EIWQQG---------------------------------------KGND-------------------------------------------------------------------------------------------------------------------------------------VP--LI------------------I-------------------GSTAQEVDFLPSDMTIRSWDWDEYTKQVTERLDTFGEAVTM----------------------------------------------------------------------------------------------------------EAMKLY-PH-DDPD--------------------------------------------------------------------ATPELIYTT-----MGSD------------------------------IRVICGNDIVAMEAAKSL-----------------------------------------TSPVYRYIV--------------------TLSPSRPFSFFGLPWEPRY-AFHM---------WDV-FAFFGNVPFFLPAHTKND----------------------------------- 774
775 ----------------------------------VWS----------P------------------RLETDALLPVFVW----I-------H---------------------------------------------------------G--------------------G----------------------------------------------------------------------------------YLMNGF------GH------Q--SGYSPDSEFV-----TS---MNVVAVS------M-N---YR-LN-------------AFGFLT---LKELWVENESY----------G---NFGLLD--QILV----------------------------------------------L-----------------------------K--WVKKN-----------------------------IQNFG---------------------GD------------------------------------------------------PNS----V-TI--V-G--QS-----------------SG-----------------------------G-TSIFG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LASLP-------A---------------E---------------GLFQRAITM-----------------------------------------------------------------------------------------S-ASPKFEKSYISAANENQVFI----------------------------------------------------------KKSKC---------------------------------------------------------------------------------------------------------KDISVKLKECLYN--L-------------------------------------------------------TSEEVIRAI----------------------------------------------------------------PNDVYPYWLMEDLLDFPKKDLFDGALIVMEPMSV----SEYPQ-NIKNINF-------------------------------------TTSDK-------------------------------------------------------------------------------------------------------------------------------------VS--VL------------------I-------------------GSTAQEIGILPGAIFTGVYQWISLKEYLDKRLLNFSLSYS-----------------------------------------------------------------------------------------------------------KIFDLY-KNINNIN--------------------------------------------------------------------DSAQYAYET-----ISSD------------------------------VRINCPSNKLAKDILLSN-----------------------------------------KYDVFRYIV--------------------TNYPNKPVSLNGFP-PSKY-AVHF---------WDS-TALFNFKAVNNYSLSETDK---------------------------------- 775
776 PDLPRQSEDC--------------------LTLNVYV--------PQN-----------T-HSE---VKE--PLAVMVW----I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------YLVGGS------EQ------F--PGHL---IAA-----QE----NVIVVT------L-N---YR-LG-------------VWGFLTS--------GDST---I-----P-G---NMGLMD--QVLA----------------------------------------------L-----------------------------R--WVQDN-----------------------------IASFG---------------------GN------------------------------------------------------PHK----V-TI--F-G--QS-----------------AG-----------------------------G-MSITL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-MVSPK-------T---------------R---------------RLFQHAIAQ-----------------------------------------------------------------------------------------S-GAVTNQVLLERNSPRWT-----------------------------------------PMLQ---------QLA----SSVGC----------------------------------------------------------PTD----------------------------------------------TN--LVQCLQ---S------V------------------------------------------------DNARLAALDN-----------M---------------------FYE---------------------------P------IV----DG--------------PGGCV----PMQP--AL------------------------------------------AWNTS------V-RH---------------------------------------------------------------------------------------------------------------------------AP--FL------------------M-------------------GVVKDEG---------------------M-------AIF-------------DMN---------LPGI----------------------DKEL-ALRDGIDFNVAMKITTMMLMKLYPGPDQPFTSLFTPEQMQF-----------VLQYYY----KHPEDS----------------------------------------------FDNL----------------R---SLMSF-----VR-D------------------------------ALFVSQ----TQQAAGSL-QQP-----T-------------------------------S-RNDTFLY-------QF-VYRDASY-----PEE-PFPM--------G-PSHA---------GEL-KYMFE------ECST--SE---------------------------------- 776
777 QTDVRGSEDC--------------------LYLNIWV----------P-----------QGKKT---VST--NLPVMVW----I-------Y---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FLW-GG------GQGPNFLQN--YLYDGQEIAT-----RG----NVIVVT------F-N---YR-LG-------------PLGFLST--------GDAN---L-----P-G---NYGLKD--QHMA----------------------------------------------I-----------------------------A--WVKRN-----------------------------IRNFG---------------------GD------------------------------------------------------PDN----I-TI--F-G--ES-----------------AG-----------------------------A-VSVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-MLSPH-------N---------------K---------------GLIKRAISQ-----------------------------------------------------------------------------------------S-GVGL---------CSWAIQKDPLYWAT--------------------------------------------KVA----EKVGC----------------------------------------------------------PTD----------------------------------------------NTTTMANCLKV--T-------------------------------------------------------DPAALT----------LGYHLDVIGL-KYPLVHYLAFS-----------------------------------P------VI----DG--------------D--FL----PDAPE-KL------------------------------------------FDN--------A-AD---------------------------------------------------------------------------------------------------------------------------ID--YI------------------A-------------------GVNNMDGHF------------------FA------SIDMPAL-------NRPLAKIKPEDVYNVAQGL---------------------------------------------------------------------TMEKGVEGAFRTFSLY-------------------------------------------------TQVWTDSVNQE----------------VMKRTVIDL-----ET-D------------------------------YIFLVP----TQQTLALHQQHA----------------------------------K--SAKTYSYVF-------S-QPSRMLIY---------PSWV--------G-ADHA---------DDL-QYVFG------KPFVTPLGY--------------------------------- 777
778 QTDVRGKEDC--------------------LYLNIWI----------P-----------QGKRE---VST--NLPVMVW----I-------Y---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FLL-GG------GQGANFLDN--YLYDGEEIAV-----RG----NVIVVT------L-N---YR-VG-------------PLGFLST--------GDPN---M-----P-G---NYGLKD--QHMA----------------------------------------------I-----------------------------A--WVKRN-----------------------------IKAFG---------------------GD------------------------------------------------------PDN----I-TI--F-G--ES-----------------AG-----------------------------A-ASVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-ILSPK-------N---------------A---------------GLFKRAISQ-----------------------------------------------------------------------------------------S-GVSL---------CSWVIQKDPLTWAK--------------------------------------------KVG----EQVGC----------------------------------------------------------PTD----------------------------------------------NTTVLANCLRA--T-------------------------------------------------------DPKALT----------LAHHVELISL-PGPLVHTLSIT-----------------------------------P------VV----DG--------------D--FL----PDMPE-NL------------------------------------------FAN--------A-AD---------------------------------------------------------------------------------------------------------------------------ID--YI------------------A-------------------GVNNMDGHF------------------FA------GFDLPAI-------NRPLQKITASDVYNLVKGL---------------------------------------------------------------------TADRGERGANLTYDLY-------------------------------------------------TELWGDNPEQQ----------------VMKRTVVDL-----AT-D------------------------------YIFLIP----TQWTLNLHHKNA----------------------------------R--SGKTYSYLF-------S-QPSRMPIY---------PSWV--------G-ADHA---------DDL-QYVFG------KPFATPLGYLPK------------------------------ 778
779 QDNTYGAEDC--------------------LYLNIWV----------P-----------QGKKE---VSR--NLPVMIW----I-------Y---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FLM-GA------GHGANFLSN--YLYDGEEIAT-----RG----NVIVVT------F-N---YR-VG-------------PLGFLST--------GDAN---L-----P-G---NYGLRD--QHMA----------------------------------------------I-----------------------------A--WVKRN-----------------------------IAAFG---------------------GD------------------------------------------------------PNN----I-TI--F-G--ES-----------------AG-----------------------------G-ASVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-TLSPY-------N---------------K---------------GLIRRAISQ-----------------------------------------------------------------------------------------S-GVAL---------CPWVIQKNPLFWAK--------------------------------------------RIA----EKVGC----------------------------------------------------------PLD----------------------------------------------DTARMARCLKV--T-------------------------------------------------------DPRALT----------LAYKMPLAGM-EYPMLHYLGFL-----------------------------------P------VV----DG--------------D--FL----PDDPV-NL------------------------------------------YVN--------T-AD---------------------------------------------------------------------------------------------------------------------------ID--YL------------------A-------------------GTNDMDGHI------------------FA------SIDMPAI-------NKQKQEVTDEDFYKLVSGL---------------------------------------------------------------------TITKGLRGANTTFDIY-------------------------------------------------TEPWALDASQE----------------TRKKTVVDF-----ET-D------------------------------ILFLVP----TKIALAQHRANA----------------------------------K--SAKTYTYLF-------S-HPSRMPTY---------PKWV--------G-ADHA---------DDI-QYVFG------KPFATPLGYRSQ------------------------------ 779
780 QDNTYGDEDC--------------------LYLNIWV----------P-----------QGKKE---VSR--DLPVMIW----I-------Y---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FLM-GA------GQGANFLSN--YLYDGEEIAT-----RG----NVIVVT------F-N---YR-VG-------------PLGFLST--------GDAN---L-----P-G---NYGLRD--QHMA----------------------------------------------I-----------------------------A--WVKRN-----------------------------IAAFG---------------------GD------------------------------------------------------PNN----I-TI--F-G--ES-----------------AG-----------------------------G-ASVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-TLSPY-------N---------------K---------------GLIRRAISQ-----------------------------------------------------------------------------------------S-GVAL---------SPWAIQKKPLFWAK--------------------------------------------KIA----EKVGC----------------------------------------------------------PVD----------------------------------------------DTSRMAKCLKI--T-------------------------------------------------------DPRALT----------LAYKMPLTGT-EYPVLHYLGFL-----------------------------------P------VV----DG--------------D--FI----PDDPM-NL------------------------------------------YAN--------A-AD---------------------------------------------------------------------------------------------------------------------------VD--YL------------------A-------------------GTNDMDGHM------------------FA------SLDMPAI-------NKNKQDITAEEFYKLVSGL---------------------------------------------------------------------TMTKGLRGANATFDLY-------------------------------------------------TEPWALDSSQE----------------TKKKTVVDF-----ET-D------------------------------VLFLMP----TETALVQHRANA----------------------------------K--SAKTYAYLF-------S-LPSRMPVY---------PSWV--------G-ADHA---------DDI-QYVFG------KPFATPLGYRSQ------------------------------ 780
781 QDNTYGEEDC--------------------LYLNIWV----------P-----------QGKKE---VSR--NLPVMIW----I-------Y---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FLM-GA------GHGANFLSN--YLYDGEEIAT-----RG----NVIVVT------F-N---YR-VG-------------PLGFLST--------GDAN---L-----P-G---NYGLRD--QHMA----------------------------------------------I-----------------------------A--WVKRN-----------------------------IAAFG---------------------GD------------------------------------------------------PNN----I-TL--F-G--ES-----------------AG-----------------------------G-ASVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-TLSPY-------N---------------K---------------GLIRRAISQ-----------------------------------------------------------------------------------------S-GVAL---------CPWVIQRNPLFWAK--------------------------------------------RIA----EKVGC----------------------------------------------------------PLD----------------------------------------------DTARMAKCLKV--T-------------------------------------------------------DPRALT----------LAYKMPLAGM-EYPMLHYLGFI-----------------------------------P------VV----DG--------------D--FI----PDDPI-NL------------------------------------------YAN--------T-AD---------------------------------------------------------------------------------------------------------------------------ID--YI------------------V-------------------GTNNMDGHI------------------FA------SIDMPAI-------NKNKQEVTDEDFYKLISGL---------------------------------------------------------------------TMIKGLRGANSTFDVY-------------------------------------------------TKPWARDATQE----------------TKKKTVVDF-----ET-D------------------------------ILFLVP----TETALAQHRANA----------------------------------K--SAKTYTYLF-------S-HPSRMPIY---------PKWV--------G-ADHA---------DDI-QYVFG------KPFATPLGYRPQ------------------------------ 781
782 QDSTYGDEDC--------------------LYLNIWV----------P-----------QGRKQ---VSR--DLPVMIW----I-------Y---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FLM-GS------GHGANFLNN--YLYDGEEIAT-----RG----NVIVVT------F-N---YR-VG-------------PLGFLST--------GDAN---L-----P-G---NYGLRD--QHMA----------------------------------------------I-----------------------------A--WVKRN-----------------------------IAAFG---------------------GD------------------------------------------------------PNN----I-TL--F-G--ES-----------------AG-----------------------------G-ASVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-TLSPY-------N---------------K---------------GLIRRAISQ-----------------------------------------------------------------------------------------S-GVAL---------SPWVIQKNPLFWAK--------------------------------------------KVA----EKVGC----------------------------------------------------------PVG----------------------------------------------DAARMAQCLKV--T-------------------------------------------------------DPRALT----------LAYKVPLAGL-EYPMLHYVGFV-----------------------------------P------VI----DG--------------D--FI----PADPI-NL------------------------------------------YAN--------A-AD---------------------------------------------------------------------------------------------------------------------------ID--YI------------------A-------------------GTNNMDGHI------------------FA------SIDMPAI-------NKGNKKVTEEDFYKLVSEF---------------------------------------------------------------------TITKGLRGAKTTFDVY-------------------------------------------------TESWAQDPSQE----------------NKKKTVVDF-----ET-D------------------------------VLFLVP----TEIALAQHRANA----------------------------------K--SAKTYAYLF-------S-HPSRMPVY---------PKWV--------G-ADHA---------DDI-QYVFG------KPFATPTGYRPQ------------------------------ 782
783 QDNTYGQEDC--------------------LYLNIWV----------P-----------QGRKQ---VSH--NLPVMVW----I-------Y---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FLM-GS------GQGANFLKN--YLYDGEEIAT-----RG----NVIVVT------F-N---YR-VG-------------PLGFLST--------GDAN---L-----P-G---NFGLRD--QHMA----------------------------------------------I-----------------------------A--WVKRN-----------------------------IAAFG---------------------GD------------------------------------------------------PDN----I-TI--F-G--ES-----------------AG-----------------------------A-ASVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-TLSPY-------N---------------K---------------GLIRRAISQ-----------------------------------------------------------------------------------------S-GMAL---------SPWAIQKNPLFWAK--------------------------------------------TIA----KKVGC----------------------------------------------------------PTE----------------------------------------------DTGKMAACLKI--T-------------------------------------------------------DPRALT----------LAYKLPVKKQ-EYPVVHYLAFI-----------------------------------P------VI----DG--------------D--FI----PDDPI-NL------------------------------------------YNN--------T-AD---------------------------------------------------------------------------------------------------------------------------ID--YI------------------A-------------------GINNMDGHL------------------FA------TIDVPAV-------DKTKQTVTEEDFYRLVSGH---------------------------------------------------------------------TVAKGLKGAQATFDIY-------------------------------------------------TESWAQDPSQE----------------NMKKTVVAF-----ET-D------------------------------VLFLIP----TEIALAQHKAHA----------------------------------K--SAKTYSYLF-------S-HPSRMPIY---------PKWM--------G-ADHA---------DDL-QYVFG------KPFATPLGYRPQ------------------------------ 783
784 QDSTYGNEDC--------------------LYLNIWV----------P-----------QGRKE---VSH--DLPVMIW----I-------Y---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FLM-GA------SQGANFLSN--YLYDGEEIAT-----RG----NVIVVT------F-N---YR-VG-------------PLGFLST--------GDSN---L-----P-G---NYGLWD--QHMA----------------------------------------------I-----------------------------A--WVKRN-----------------------------IEAFG---------------------GD------------------------------------------------------PDN----I-TL--F-G--ES-----------------AG-----------------------------G-ASVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-TLSPY-------N---------------K---------------GLIKRAISQ-----------------------------------------------------------------------------------------S-GVGL---------CPWAIQQDPLFWAK--------------------------------------------RIA----EKVGC----------------------------------------------------------PVD----------------------------------------------DTSKMAGCLKI--T-------------------------------------------------------DPRALT----------LAYKLPLGST-EYPKLHYLSFV-----------------------------------P------VI----DG--------------D--FI----PDDPV-NL------------------------------------------YAN--------A-AD---------------------------------------------------------------------------------------------------------------------------VD--YI------------------A-------------------GTNDMDGHL------------------FV------GMDVPAI-------NSNKQDVTEEDFYKLVSGL---------------------------------------------------------------------TVTKGLRGANATYEVY-------------------------------------------------TEPWAQDSSQE----------------TRKKTMVDL-----ET-D------------------------------ILFLIP----TKIAVAQHKSHA----------------------------------K--SANTYTYLF-------S-QPSRMPIY---------PKWM--------G-ADHA---------DDL-QYVFG------KPFATPLGYRAQ------------------------------ 784
785 ATDVIGSEDC--------------------LYLNIWV----------P-----------QGR-T---VSS--NLPVMVF----I-------Y---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FLL-GG------GQGANFLDN--YLYDGEEMAD-----RG----NVIVVT------F-N---YR-VG-------------ALGFMST--------GDDG---I-----P-G---NYGLWD--QHAA----------------------------------------------I-----------------------------S--WVHRN-----------------------------IKAFG---------------------GN------------------------------------------------------PDN----I-TL--F-G--ES-----------------AG-----------------------------A-ASVNF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-IITPK-------N---------------K---------------GMIRRAISQ-----------------------------------------------------------------------------------------S-GVAL---------CPWAISRNPRQFAE--------------------------------------------EIA----TKVGC----------------------------------------------------------PID------------------------------------------------SGMADCLKR--A-------------------------------------------------------DPKAVT----------LAGKLKLTSSPDAPIVHNLYLS-----------------------------------P------VI----DG--------------D--FI----PDEPE-TL------------------------------------------FGN--------A-AD---------------------------------------------------------------------------------------------------------------------------ID--YI------------------A-------------------GVNDMDAHI------------------FA------TIDIPSI-------NNALTTTPVEEVQALATAL---------------------------------------------------------------------SRDRGQDAGIATFQEY-------------------------------------------------TVNWGDKPNKE----------------KVKQTVVEL-----ET-D------------------------------FMFLVP----TQAALYLHTDNA----------------------------------K--SARTFSYLF-------T-ESSRIPVF---------PLWM--------G-ADHA---------DEL-QYVFG------KPFATPLGYFPC------------------------------ 785
786 -----------------------------------------------------------------------------------I-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------F---VM------GS------S--SFFDASNL-----S-GF---GNVVVVT------A-N---YR-LG-------------PIGFLAT--------DD--DTSK-------G---NYGLWD--QHMV----------------------------------------------I-----------------------------Q--WVHDN-----------------------------IASFG---------------------GD------------------------------------------------------PHR----V-TL--F-G--ES-----------------AG-----------------------------G-ASSFY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-AMYPP-------N---------------K---------------GLIHRIISE-----------------------------------------------------------------------------------------S-GTAI-------C----PWA-Y---GEKATV---------------------------GRFAK---------LLG----LKLNC----------------------------------------------------------S----IAT-----------------------------------------NS-ELLSCLRT--K-------------------------------------------------------PYEDLISNAQ----VGTQEDEIYRPEWT---------------------------------------------P------VV----DK--------------E--FI----KMLPPDN--------------------YLYPETMYADVRDALVDLDLLIGVND---GDGG-F-IT---------------------------------------------------------------------------------------------------------------------------MV--SL------------------L-------------------PFVHSKVTPSYPAI----------------------------------------------------------------------------------------------------------------------------------------DVV-NNYVTNSM--LTD----RFGITLD---------SLADIMSFVYTNWSGSE--TN----------------DT----YRQKLLDM-----TT-D------------------------------YQFFIPAYVS--------AQTLVKLQAP-------------------------------ERHTYKYLF----------THRSPFGRPIPW------VP--------G-AAHG---------DEL-AYVFG------------FP---------------------------------- 786
787 GGTPFISEDC--------------------LSLNIYA----------P---------------AAAHTTGN--LPVMVW----F-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------F---VM------GS------S--SFFDASNL-----S-GF---GNVVVVT------A-N---YR-LG-------------PIGFLAT--------DD--DTSK-------G---NYGLWD--QHMV----------------------------------------------I-----------------------------Q--WVHDN-----------------------------IAFFG---------------------GD------------------------------------------------------PHR----V-TL--F-G--ES-----------------AG-----------------------------G-ASSFY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-AMYPP-------N---------------K---------------GLIHRIISE-----------------------------------------------------------------------------------------S-GTAI-------C----PWA-Y---GEKATV---------------------------GRFAK---------FLG----LKLNC----------------------------------------------------------S----IAT-----------------------------------------NS-ELLSCLRT--K-------------------------------------------------------PYEDLISNAQ----VGTQEDEIYRPEWT---------------------------------------------P------VV----DN--------------E--FI----KMLPPDN--------------------YLYPETMYADVRDALADLDLLLGVND---GDGG-F-IT---------------------------------------------------------------------------------------------------------------------------MV--SL------------------L-------------------PFVQSKVTHSYPAI----------------------------------------------------------------------------------------------------------------------------------------DVV-NNYVTNSM--LTD----RFGITLD---------SLADIMSFVYTNWSASE--TN----------------DT----YRQKLLDM-----TT-D------------------------------YQFFIPAYVS--------AQALVKLQAP-------------------------------ERHTYKYLF----------THRSPFGRPIPW------VP--------G-AAHG---------DEL-AYVFG------------FPSSMQTGPSFQ------------------------ 787
788 --------------------------------------------------------------------------PVMVW----F-------H---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------F---VI------GQ------S--SIYDASNL-----S-GF---GNVVVVT------A-N---YR-LG-------------PIGFLAT--------DD--DTSK-------G---NYGLWD--QRMV----------------------------------------------I-----------------------------Q--WVHDN-----------------------------IASFG---------------------GD------------------------------------------------------PHR----V-TL--F-G--ES-----------------AG-----------------------------G-ASSFY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-AMYPP-------N---------------K---------------GLIHRIISE-----------------------------------------------------------------------------------------S-GTAI-------C----PWA-Y---GDKSTV---------------------------GRFAK---------LLG----LKLNC----------------------------------------------------------S----IAT-----------------------------------------NS-ELLSCLRT--K-------------------------------------------------------PYEDLISNAQ----VGTQEDEIYRPEWT---------------------------------------------P------VV----DN--------------E--FI----KMLPPDN--------------------YLYPETMYADVRDALADLDLLIGVND---GDGG-F-IT---------------------------------------------------------------------------------------------------------------------------MV--SL------------------F-------------------PFVQSKVTPSYRAI----------------------------------------------------------------------------------------------------------------------------------------NVV-NNYVTNSM--LTD----RFGHTLE---------SVVDVMSFVYTNWSASE--TN----------------NT----YLQKVLDM-----AT-D------------------------------YQFFIPAYVS--------ARALFQLQAP-------------------------------ERHTYKYLF----------THRSSFGKFIPW------VP--------G-AGHG---------DEI-PYVFG------------FP---------------------------------- 788
789 --------------------------------MQVGT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVIYVN------F-N---YR-LG-------------PFGWPQGQESEDQGV---------------L---NLGLHD--HIAA----------------------------------------------L-----------------------------Q--WVQHN-----------------------------IHHFG---------------------GD------------------------------------------------------RNK----V-TI--F-G--ES-----------------AG-----------------------------SISNGIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LNSGL-----------------------E---------------RLARGAIFQ-----------------------------------------------------------------------------------------S-GQANSVINPKASYREDVWQRLIR-------------------------------------------------------AMPSC-------------------------------------------------------------------------------------------------------AATSESGSSIPCLREASSVEILTAWLQIFQEIQDFILFL-----------------------------------------------------------------------------------------------------------P------TIDPARGS-----------------LL----PDYPS-RL------------------------------------------YSQGRFARIPFIS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTNLDEGTAF--------------------------------------------------------------------------------ANSNPNATEDNIKGHIIGYNSPSPDEKGLARVVDELFDVYPDVPSLGSPFNTGDELFGLSRSY--------------------------------------------------------------------------------KRHAA-----ILTD------------------------------MVFEAPRRMWLEAATSR------------------------------------------GVKAWSYLFKQPQPLDNPAW---------------------------G-VYHS---------SEI-EFVY------------------------------------------------- 789
790 ----------------------------------VYT------------------------------KDLKGRRPVIVF----L-------H---------------------------------------------------------P--------------------G----GFYVFSGQS--------------------------------------------------------------------KYLA-GP--------------------------------EHFMDRDCVLVS------L-N---YR-LG-------------SLGFLAT--------GSKE---------APG---NAGLKD--QVLA----------------------------------------------L-----------------------------R--WIQQH-----------------------------IQRFG---------------------GD------------------------------------------------------PDS----V-TL--L-G--YS-----------------AG-----------------------------S-ISVAL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-MLSPM-------S---------------R---------------GLFHRGICM-----------------------------------------------------------------------------------------S----------------------------------------------------------AAPYGPVKYKDNDLQLAKRQAGLLKC--------------------------------------------------------------------------------------------------------PQESIGEMVECMRRK----------------------------------------------------------------------------------------------------------------------------------PYLDYVSTY----NG-----------------MFEFGWNPVLNWRI------------------------------------------VVEKDFGQERYL------------------------------------------------------------------------------------------------------------------------------------------------------IESPFKTARRGDFHKVALITGITEFEFLSGAFFDLRNE---------------------------------------------------------------------------------------------------------------------------------SIVNRY---------------------------------NRDWEHYASIALLLEQNSTQSRAASRVFREKYMPESLDKLEYPKSLKGMGEL-----LS-D--------------------ALIGVSFHRFLQLMSP-----------------------------------------------------HTPIYTYLFRYKGRYTFLKNPDNQQTI--------------------GPVHH----------DEL-IYLFHVGLLIPLLKRED------------------------------------ 790
791 -VFSPYDTD-----------------------------------------------------------DESKTYPILVW----I-------H---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------FLAGSA--------------D--TGIDMEVIAANIVSKG------IAFVS------I-N---YR-LG-------------PLGFMNYQNGDKLE----------------G---NFGIWD--MVMA----------------------------------------------L-----------------------------Q--WIQSN-----------------------------IKQFN---------------------GD------------------------------------------------------PTK----V-TV--M-G--ES-----------------AG-----------------------------G-AASSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-ALSPK-------T---------------S---------------GLLHQAIIM-----------------------------------------------------------------------------------------SGSSMAGWAIHRHSQPAYSVDNLVAYFRSLRKGCEKWINEDDTKEVVGDEYQHLTHSVIRSALCNYQNVK------------INC----------------------------------------------------------------------------------------------LTDDM-------TQMDK-MNCLRKELN-------------------------------------------------------FSSPLFRKALAAELGVSKMV-------------------------------------------------------------V----DG--------------D--LV----PSSGV-SL------------------------------------------VRNNARIPIMTG------------------------------------------------------------------------------------------------------------------------------------------------------VARKEWGHKKAMFYNMHQRDGLKRSD---------------------------------------------------------------------------------------------------------------------------------------------VEEQVYRIIDNSFHETASEKLANSTVQLIANATIVRYLETPNNEFIADQVVGALQK----------------------------------------LESD------------------------------IEFVAP----CEREVAAYVDK--------------------------------------GVPVYLYSFDYVPKSPILESERKIYSLFGTKPVEMKRTEKSEILE--KAAFHG---------LDH-AFIFSKGYSSNFEISPYTKREE------------------------------- 791
792 LQMPA-SEDC--------------------LYLNVFA--------PNP-------------MPA----N---A-AVMVY----F-------P---------------------------------------------------------G--------------------G----A-----------------------------------------------------------------------------FKF-GG------AS------N--PNYAGVSLAA-----SS----DVIIVT------V-G---YR-VS-------------VFGIFST--------GDEV---A-----P-G---NYAMLD--QVAA----------------------------------------------L-----------------------------Q--WVHNN-----------------------------IEAFG---------------------GN------------------------------------------------------KEK----V-TI--F-G--QS-----------------SG-----------------------------A-GSVGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLSKL-------S---------------A---------------SFFSQAILQ-----------------------------------------------------------------------------------------S-GSAL---------SPRYFRN--DPEE---D---------------------------RRDAM---------ELA----SAVGC-----------------------------------------------------------PST---------------------------------------------DSIAMVTCLR---T------V------------------------------------------------DEMTLLQV----Q-DSVYQSGY-----------------------F---------------------------I------RL----DG--------------I--FL----EDTPD-NL------------------------------------------LYGED------S-IP---------------------------------------------------------------------------------------------------------------------------LPAAIM------------------A-------------------GFNSQEGTA------------------SV-------RSFFPEYTTRE--TGPFIN---------RSMF----------------------KTMV-HSSLLGSDK----H----------------------S-LIR-E---------SVYQEY----VDWSRV--------------------------------------DY---DD-LDYF----------------D---AYVPF-----YS-D------------------------------YIWRSG----SDASVRRY-YEL-----G-------------------------------VANIYQYYF-------TH-TPSSSFSRAGPVNPT---WL--------G-AGHT---------EEF-QFVFG------WSFD--ENILQYK-HELTDDE--------------------- 792
793 ------------------------------------------------------------------------KYPVIFF----I-------Q---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FSVGTS--------------M--FIYSSEVLS------TY---NDVVVVT------F-N---YR-LQ-------------ALGYLSTQDDVAPG--------------------NWGMWD--QVAA----------------------------------------------L-----------------------------K--WVKQN-----------------------------IEYFN---------------------GD------------------------------------------------------PDA----I-TA--Y-G--QS-----------------AG-----------------------------A-VSVGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-MLS--PQ-----S---------------K---------------GLFNQAITQ-----------------------------------------------------------------------------------------S-GSAHVNWAVKLPPYDP---MDSTIELA---------------------------------------------------TKMDC-------------------------------------------------------------------------------------------------------PTGTSTE-IIDCLRT-------------------------KNAFDIVA---N-----------AFTIMDYDQLGFM----------------------------------------------------------------------V------VV----DG--------------PGNFL----PDDPF-SL------------------------------------------MERGE------Y-QK---------------------------------------------------------------------------------------------------------------------------MP--YM------------------S-------------------GYTKSELAVSAMAGIEDPNSGITRQEFREKIMKLV------------------TA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKYDSCSDV-----IHEDI--A--------------------------RSMEFYYLPWEAPRDKIRLRDQYIKLESDADFVAGVHYSAL------------GMLNDEDNPKYIYRFDYESESARYDDYV-------------------------E-VPHL---------EDL-FYCFGRPHKRPLVDILPVPGFVKILERRWTDTD-------------------- 793
794 LPSANQSEDC--------------------LYLNVFA----------------------------PKIRED------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNICK--LL-VS---REIIVVT------F-H---YR-LG-------------FLGFLST--------GDDV---------CPG---NYGLFD--MLEA----------------------------------------------M-----------------------------R--WVHAN-----------------------------ISSFG---------------------GD------------------------------------------------------PEN----I-TL--S-G--QS-----------------AG-----------------------------A-AAAGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-SFSPL-------T---------------K---------------GLFKRKIVM-----------------------------------------------------------------------------------------G-GNSY---------CHWATTSNHHIREYCKK---------------------------WAKRLGWKPQLNYANKREESVDIFNFFYGL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTSKLGMTM-----------------------FFSNTIFKECHL--------HFHFHLLQLLIKRFSHT-----TGNFSEKLKSMCPQLLVAE-------------------------------------------------------------------------------------------------------------------------------------SAIGLL------------------R-------------------GTEKEIDSAIDVLSRKNGLSR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKIETMTEK-----VYGDS--PALRADLKARKMLFVQLISDIFANYGIYRFMRD-------------------------------------------------CQQRSVECYGYSF-------DHRSKRMWGWLQHVAPFT-------------G-GTHT---------SEI-TYLFDCNALSTPLGMSK------------------------------------ 794
795 LPSANQSEDC--------------------LYLNVFA----------------------------PKIREDKKYPVLFY----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------YVM-DS--------------A--ERYTAKNICK--LL-VS---REIIVVT------F-H---YR-LG-------------FLGFLST--------GDDV---------CPG---NYGLFD--MLEA----------------------------------------------M-----------------------------R--WVHAN-----------------------------ISSFG---------------------GD------------------------------------------------------PEN----I-TL--S-G--QS-----------------AG-----------------------------A-AAADL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-SFSPL-------T---------------K---------------GLFKRKIVM-----------------------------------------------------------------------------------------G-GNSY---------CHWATTSNHDIREYCKK---------------------------WAKRLGWKPQLNYANKREESVDIFNFFNGL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTSKLGMTM-----------------------FFSNTIFKECQLPLAPVIDGEILPHDLKVLRETQEHVPSLVGGGEYEALL--FC---------------------------------------------------------------------------------------------------------------------------------------------AIGLL------------------R-------------------GTEKEINSAIDVLSRKNRLSR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SKIEAMTEK-----VYGDS--PALRADSKARKMFFVQLISDIFANYGNYRFMRD-------------------------------------------------CQQRGVECYGYSF-------DHQSKQMWGWLQHVVPFT-------------G-GTHT---------SEL-SYLFDCNYMSAPLGMNK------------------------------------ 795
796 PKTSPQSEDN--------------------LTLNIFT--------------------------PVWTPKNETGFPVILY----I-------H---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FVS-DS--------------A--HKYGDMSICQHL---VT---KDVVVVT------I-Q---YR-LG-------------FLGFWTT--------GDSS---------IPD---NVALHD--MVFA----------------------------------------------L-----------------------------K--WVKEN-----------------------------IGLFN---------------------GD------------------------------------------------------PNN----I-TL--M-G--QS-----------------AG-----------------------------G-ASVDF---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-SISPV-------S---------------R---------------DLFQKVIPM-----------------------------------------------------------------------------------------G-GNAS---------CSWAIHPRPLNACRNRA------------------------------------------------QEIGV-------------------------------------------------------------------------------------------------------FDGMNTLDWVEKLREL---------------------------------------------------------PADKFASALNMEAVDTKTD------------------------------------------------------P----ELLIGPKYDN-----------------LF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPRPVM------ELRKEAPMKPRLL-------------------GCAKSEGLVFAFFGLNTKHPLHAVQQDVSAILSEKLFPLKARDYQEK----------------------------------------------------------------------------------------------------ALEKLI-EIGTDHSKE------------------------------------------------------------------EWQRAMVDL-----KG-D------------------------------SFLNVGIQQNVLDVLETQP----------------------------------------STPIYMYSFDYCNPKAYGIMGFKLPF---------------------KDATHC---------TDI-SYVVGNHIVNSFDFNEED----------------------------------- 796
797 YNTWTISENC--------------------LTLDVYT--------RSL-----------T-GTS----------SIV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YDF-------------------------RAYSS-----VK----DIVMVS------I-Q---YR-LG-------------PLGWAGM--------GDEH---M-----P-S---NLGFQD--QVLA----------------------------------------------L-----------------------------T--WVQEN-----------------------------IKNFG---------------------GD------------------------------------------------------PDQ----V-TI--F-G--QS-----------------AG-----------------------------G-YSVSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-IASPM-------S---------------K---------------GLFKRAIAQ-----------------------------------------------------------------------------------------S-GAFLQTVLAPPFYNN----------T--------------------------------AATI---------EFA----ECLGC----------------------------------------------------------PS-----------------------------------------------ESHAMAECLR---N------F------------------------------------------------PAERFA-VSRSNP-C----SRI---------------------LMQ---------------------------P------AL----DG--------------S--FF----PDNIE-KL------------------------------------------VKTKQ------Y-NR--------------------------------------------------------------------------------------------------------------------------DID--II------------------L-------------------GTVQNEGYF------------------LT-------SGKAPHLVSPD------TS---------LQKV----------------------EEFI-YGVLSKRYPHLPQKA-------------------RRAHVQE-----------AMETYV----RDPKPN-----------------------------------------------GLI----------------E---AATQF-----MG-D------------------------------SLILWP----TYAFALGL-ADT-----M-------------------------------KGNTFFYEL-------RH-RPSIS--------RR-PYFI--------G-PDHC---------DDL-PMMLG------SQFT--GK------------LGLFPVELSEED---------- 797
798 YNKWKLSEDC--------------------LTLDVYT--------RST-----------T-GKR----------PVIVY----I-------H---------------------------------------------------------G--------------------G----ALQAGQMNE---------------------------------------------------------------------YDF-------------------------RAYSS-----VR----DIVVVP------I-Q---YR-LG-------------ALGWASM--------EDEH---M-----P-A---NLGFQD--QVMA----------------------------------------------L-----------------------------K--WVQQN-----------------------------IHHFG---------------------GD------------------------------------------------------PNQ----V-TI--I-G--QS-----------------AG-----------------------------G-WSITM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-IISPM-------S---------------K---------------GLFKRAIAQ-----------------------------------------------------------------------------------------S-GSIIR---ASSFSPNVLVSS---MGT--------------------------------CMSL---------FMQ----EFSGC----------------------------------------------------------PSN----------------------------------------------DSRAMAECFR---K------L------------------------------------------------PVERFA-ASESEP-C----KQK---------------------LLA---------------------------T------A-----DG--------------V--YL----PDDPE-KL------------------------------------------LRTGQ------Y-NK--------------------------------------------------------------------------------------------------------------------------DID--VI------------------M-------------------GTMSTEGYW------------------LS-------ATRIPPLVAED------TS---------LERV----------------------QGYF-LHEITRRYPRLPLYV-------------------RQAAVAA-----------AVVAYV----RDTRTN-----------------------------------------------GLI----------------K---AATEF-----FG-D------------------------------SFLLWP----TYATALDF-SKT-----L-------------------------------EGKTYFYQI-------RH-RPSIS--------NH-PDFI--------G-SDHC---------DDL-VLMLG------TQFT--NG------------FGVIPLTISDED---------- 798
799 NATNNW-------------------------------------------------------------------LPVMVW----V-------Y---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------FTG-GS------NN----------MYPGTAILNYAQH-TD---KPFIYVA------L-N---YR-LG-------------AFGWGTGSGFAENHAANL------------------GLKD--IIKG----------------------------------------------L-----------------------------T--WVQEN-----------------------------IWAFG---------------------GN------------------------------------------------------PEK----V-TV--F-G--ES-----------------AG-----------------------------A-ISISL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-FL---NQ-----S---------------T---------------TLFSGAIME-----------------------------------------------------------------------------------------S-GAQS------------------------TV---------------------------PLGPTNTTWESAYVSLL----DVTNC----------------------------------------------------------TTPSEKNVTQ---------------------------------------FQ-----CLK---EMPAQNLL------------------------------------------------KGQLTVQSQAQF-----SAGFIFG-------------------------------------------------P------TI----DG--------------K--LI----PGSPH-TL------------------------------------------ISEGHFA-------K---------------------------------------------------------------------------------------------------------------------------KP--FI------------------T-------------------GNNKDEGTNF-------VP-------TTI------NSTL-YG------------------------------------------------LGIIALGEPV----DPTKETLEKVLALYPNVPSLGSPFDTGNETF------------GLDPSF----------------------------------------------------------------------------K---QFAAI-----YG-D------------------------------AQFQAP----RRFFLRESNKHG-------------------------------------NTQTWTYLFEQY------TPGAPPYL---------------------G-SHHG---------SEV-IY--------------------------------------------------- 799
800 DHAPNQSEDC--------------------LNLNVYT------------------------PA-RMLGNSGRKLPVLVF----I-------Y---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------FTS-GK------NS------N--PLFNGASFLQVVAQ-ER----QTVIVV------P-N---YR-VG-------------VFGFLSSMELM----REGS-----------L---NAGLMD--QAAA----------------------------------------------F-----------------------------G--WVKQN-----------------------------IEAFG---------------------GD------------------------------------------------------SSL----I-TA--W-G--QS-----------------AG-----------------------------A-ISIAT---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LMQYGGK-----N---------------P-------------DNTPFDRMILQ-----------------------------------------------------------------------------------------SGGLPP---------------VLNTPYQ---------------------------------GQNDFDKV----------ALSVNC----------------------------------------------------------PKTSA--------------------------------------------V--PVMDCLRS--V-------------------------------------------------------DASTLFKESFKLQ----LIYR----------------------------------------------------P------SV----DG--------------T--YI----TEQPYKAI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VGQRLDRVPAI-----------MLG-------------------NTDEGTYFAI---------------------------------------------------------------------------------------KAGVDSPEAARKFMHKSLDFL-----------------------KLPMYEQLDALY-PVDGP----I-----------------------------------------------------------------SPVFRGGAP-----YG-D------------------------------GIFNCP----SRQISQFLSNQ--------------------------------------GDDAEVYK--GRFNVKPSLLPPGKDALKNA-----------------G-VYHG---------AEL-AYTWNYSSLLDPHNGDRAI---------------------------------- 800
801 SSTLKMSENC--------------------LNLDVYL----------P-----------VQYNG----VYSSGLPVVVY----F-------Y---------------------------------------------------------G--------------------G----D-----------------------------------------------------------------------------FDH-GH------NS------Q--PYYNGDSFLQ-AQA-TD---RQVIIVV------P-N---YR-TN-------------VFGFMASQELASEGSLNP------------------GLLD--QVAA----------------------------------------------L-----------------------------K--WVKKY-----------------------------IKGFG---------------------GN------------------------------------------------------PNN----V-VA--W-G--HS-----------------AG-----------------------------A-TSISL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LMGNGGN-----S---------------S---------------YFNR-MILQ-----------------------------------------------------------------------------------------S-GGMA-------------------SVLNTPK---------------------------LVQPDFTKLATAVGCNT----TATT--------------------------------------------------------------------------------------------------------------------------TTMACM---------------------------------------------------RNVDANVLSNA-ANNLNFRYY--------------------------------------------------P------VV----DG--------------Q--YL----IEQPS-SA------------------------------------------LAAQRVR-------K---------------------------------------------------------------------------------------------------------------------------ID--SV-----------------IT-------------------TVTNEG---------------------------------------------------------------------------------------------T-------RFAIDSSVSNIKSDSTYRRGSVSFLNTSSSNAFDLYYPASANSSAL----------------------------------------------------------------------------K---ITSDS-----YG-D------------------------------SEYNAP----AFQLAQYLVSG--------------------------------------SNPVAVYKGRFNIKPSIVANQRYKAI---------------------G-VFHE---------SDL-PFMWAYS---------------------------------------------- 801
802 PIPEGSSEDC--------------------LFLDVYA----------P---------------ARPRRDSSRLLPVYVF----I-------Q---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------F---SS------NG------N--PYYNGSGLIQ---A-SD---MNIVVVN------F-N---YR-VG-------------PYGFLAG--------SEILEGGS-------L---NNGLRD--QIQV----------------------------------------------L-----------------------------K--WVQKH-----------------------------ISKFG---------------------GN------------------------------------------------------PDH----V-VI--G-G--DS-----------------AG-----------------------------G-ASVTL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LSAYE-------G---------------R-------------DDGLFHAAAAE-----------------------------------------------------------------------------------------S-QSFA-------TMLTVDESQF---AYD--------------------------------------------NLV----NRTGC----------------------------------------------------------S----DTG--------------------------------------------DTLNCLRS--L-------------------------------------------------------DVEDLQRE-------------NIVTPFP---------------------------------------------G------AQQP----------------------------------------------------PLYMYGPT---------IDGDLIPDYTYRLFQQGK-F-IH---------------------------------------------------------------------------------------------------------------------------VP--VI------------------F-------------------GDVTNEGTKFVP-----------------------------------------------------------------------------------------------------------------------------------------EDLV-SDTATYVW--LQS----------------QWPALTPKHFSRIHEYYLQ---DVN----------------STRPFPNATRYWRP-----VS-DA--------------------------YGEIRYVCPGIAL--------NAAYAKAGIP----------------------------------NWNYHY-------AVQDPEDEASGLGVY--------------------HV---------VEL-NAIWGPDNIWWSDTISQPPPESYFTFN-------------------------- 802
803 DTFTNQSEDC--------------------LFVNVIK----------P-----------AYIPS------KQKLPVLVW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FML-GD------TS----------SYDGTPIVERSMT-LG---TPVIYVS------I-N---YR-MS-------------AYGFLPGKEAKEAGIGNI------------------GILD--QVAG----------------------------------------------L-----------------------------E--WVQKH-----------------------------IYRFG---------------------GD------------------------------------------------------SNK----V-IL--W-G--ES-----------------AG-----------------------------A-SSVGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LVRNDGD-----T---------------K---------------GLFHGAFMQ-----------------------------------------------------------------------------------------S-GS--------------------------PV---------------------------PFGDIERG-QPQFDKLV----EDTGC----------------------------------------------------------SDAADK-------------------------------------------ID-----CLR---SVPHDQL---------------------------------------------------QSVITKAPNLL-GYHSLKLPFG-------------------------------------------------P------TI----DG--------------K--VL----VRNPQ-VS------------------------------------------LIKGLYA-------K---------------------------------------------------------------------------------------------------------------------------VP--IV------------------S-------------------GACDDEATIF-------SF-------GSQ------NVTTDAE------------------------------------------------FKEFLRG-YL----PVTQDKIDMIAALYPEDPTAGSPFGTGSAN-------------ALTPQF----------------------------------------------------------------------------K---RIAAF-----HG-D------------------------------WRFHAA----RRFFVSRVSK---------------------------------------TQPTWSFLWKRG------K--ALPYV---------------------G-AAHT---------YEI-PEFFASGNNPDYIG--------------------------------------- 803
804 DTFENQSEDCQLSSFSIPPKPETYAVLTSGLFINVIK----------P-----------AHIPK------GKKLPVLFW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FML-GD------TS----------SYNGVPLVERSLV-LD---QPVIYVS------I-N---HR-LS-------------AYGFLGGKEAKDAGLGNI------------------GIRD--QVAA----------------------------------------------L-----------------------------E--WVQRY-----------------------------IHKFG---------------------GD------------------------------------------------------SGK----V-TI--W-G--ES-----------------AG-----------------------------A-AAVGI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LVRNDGD-----T---------------K---------------GLFHAAFMQ-----------------------------------------------------------------------------------------S-GG--------------------------PI---------------------------PWNPIEAG-QEPFDTLA----RDTGC----------------------------------------------------------FEASDK-------------------------------------------IA-----CLR---DLPYERF---------------------------------------------------HAAVMKAPDLL-GYAPFKLPFG-------------------------------------------------P------ST----DG--------------I--VV----TRNLF-QS------------------------------------------VALGLYA-------K---------------------------------------------------------------------------------------------------------------------------VP--II------------------M-------------------GNCDDEGTMF-------SF-------GSQ------NVTYGCL------------------------------------------------LSVNL-----------------------------GSPFGTGNAN-------------ALTPQF----------------------------------------------------------------------------K---RIAAF-----QT-D------------------------------WLFHST----RRFFMSYASK---------------------------------------TQPNWYYLWKRG------K--DTPYI---------------------G-AAHT---------QEI-PEIFGTGENPDYIG--------------------------------------- 804
805 ----------------------------------------------------------------------------VVW----I-------F---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FQL-GS------TS----------MYDGGMIVKRAVD-QR---QPVIFVS------M-N---YR-LS-------------GFGFMASKEIRDAGVGNI------------------GLHD--QREA----------------------------------------------L-----------------------------R--WIKKH-----------------------------ISAFG---------------------GD------------------------------------------------------PDK----V-TI--W-G--ES-----------------AG-----------------------------A-ISVAL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-MTAYDGN-----H---------------E---------------GLFRGGFMQ-----------------------------------------------------------------------------------------S-GA--------------------------PI---------------------------PVGPLENG-QVYYDDVV----RETGC----------------------------------------------------------AGSSDT-------------------------------------------LE-----CLR---GVPYNRL---------------------------------------------------KAAINKSPSIF-DYQSLRLAWL-------------------------------------------------P------RT----DG--------------V--FL----TDDPL-KL------------------------------------------VQQGKVA-------R---------------------------------------------------------------------------------------------------------------------------VP--FVNGMYASCHPMFPLDPSETL-------------------GNCDDEGTLF-------SL-------ATL------NVTTDAG------------------------------------------------FKNWVKNVFL----RIPDEQVERIAQLYPSTPSAGSPFGTGNRN-------------ALTPQF----------------------------------------------------------------------------K---RFAAF-----QG-D------------------------------GVFQAP----RRWFLQHTAH---------------------------------------RQDVWTYVHKRL------K--GLPVL---------------------G-AAHA---------TDL-LNSFF------------------------------------------------ 805
806 GVGGPISEDC--------------------LYANVFT---------------------------NQYCMKRKNCSVMIV----V-------H---------------------------------------------------------G--------------------G----R-----------------------------------------------------------------------------ILTESA--------------S--A-FNPEILVNNFVGQGR----NIVVVT------F-N---YR-LG-------------TFGF-GVLNGEKGD----------------S---NVGMFD--MLEA----------------------------------------------V-----------------------------K--WTRKE-----------------------------VHNFG---------------------GN------------------------------------------------------KDK----L-TM--V-G--HS-----------------AG-----------------------------G-SLVGA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-TSSPL-------S---------------K---------------GMLNQQIIM-----------------------------------------------------------------------------------------SGA--------------------------------------------------------LYQMGKLANFKGMTAMA----QKAGC----------------------------------------------------------------------------------------------LPEVFGFRKLSQVRIDKTYSCLRNI----------------------------------------------------------SA---QEVLDAQLWVLQNTTYYISV-----------------------------------------------P------HI----DG--------------E--FL----LNYSD-EI------------------------------------------LASGTIHPINSM------------------------------------------------------------------------------------------------------------------------------------------------------I-------------------GTTTAE---------------------------------------------------------------------------------------------------------------------------------------------LRDPIY-INDLKNADKKEELLKN----LCEHIGYELYTE-------PEEFSRKCQKFYGNG-------------------------DDAQF-----LADD------------------------------MEFYDG----SIKVANAHASK--------------------------------------NTKVFIY--DYKDAGPAFKKYAQA-----------------------PPPHHS---------EDL-IYVFGTSRGN------------------------------------------- 806
807 PNGKQADTDH--------------------LIHN-----------GNP-------------------QNTTNGLPILIW----I-------Y---------------------------------------------------------G--------------------G----G-----------------------------------------------------------------------------FMT-GS------AT------L--DIYNADIMAA-----VG----NVIVAS------F-Q---YR-VG-------------AFGFLHLAPEMPSEFAEEA---------P-G---NVGLWD--QALA----------------------------------------------I-----------------------------R--WLKDN-----------------------------AHAFG---------------------GN------------------------------------------------------PEW----M-TL--F-G--ES-----------------AG-----------------------------S-SSVNA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-LMSPV-------T---------------R---------------GLVKRGMMQ-----------------------------------------------------------------------------------------S-GTMN---------APWSHMT-------------------------------------SEKAV---------EIGKALINDCNC----------------------------------------------------------NASMLKT------------------------------------------NPAHVMSCMRS--V-------------------------------------------------------DAKTISVQQWNSYSGILSFPSA---------------------------------------------------P------TI----DG--------------A--FL----PADPM-TL------------------------------------------MKTAD------L-KD---------------------------------------------------------------------------------------------------------------------------YD--IL------------------M-------------------GNVRDEGTY------------------FLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAERE--------------------------------------------------------------------------------AIIFQY------------------------------------------------TSWEGNPGYQNQ----------------Q---QIGRA-----VG-D------------------------------HFFTCP----TNEYAQAL-AER-------------------------------------GASVHYYYF-------TH-RTSTSLW---------GEWM--------G-VLHG---------DEI-EYFFG------QPLNNSLQYRPV------------------------------ 807
808 --------------------------------------------------------------GNPISSASPSSLPRSLC----T-------R---------------------------------------------------------R--------------------S----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PAV---CFGRLD--QRLG----------------------------------------------L-----------------------------E--WVHDN-----------------------------VASFG---------------------GD------------------------------------------------------PGR----V-TL--F-G--ES-----------------AG-----------------------------A-MSIGQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LHM---------D---------------G-------------AGVLFQQVVMQ-----------------------------------------------------------------------------------------S----------------------------------------------------------NPMGYRFRSVTVANFLGEAMKRGLDC--------------------------------------------------------------------------------------------------------------FSLDCLQTEPASEVMRVQESIMGLPRSVGDFFTWGPVITDRNYRRHVGKHRKTWNCDTYEEEAEERERQESRTVTLTGLALAAAAEHASAAKA----------------------------------------------PGGRGVMSRGRGRD---------------EGQAL----PPVPV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ML--------------------------------------GVNSHEGLMFVHGAFPVTMPKLVYYSFVTALFRTSVI--------------------------------------------------------------------------------------------------------------GVLRAYGHLADQCEESG-----------------------------------------------------------------DYRRVMSQI-----MH-D------------------------------YLFRCPNLRAAQLLQEQNGR---------------------------------------DAPVFVYEFSHPTEVPGFPECS-------------------------GSSCHT---------AEL-PYVF------------------------------------------------- 808
809 ------------------------------------------------V--------------------------IYIH----------------------------------------------------------------------G--------------------K------------------------------------------------------------------------------------------------------------------------------------------YG-----------------------------------------------------------------------------------------------------------------------------------------------------------------TAEEAE-----------------------H--YK---KFFNEEDIIG--FEYTSEYPWDFQ--------------KEFSNFIDNIYMK---------------YKKI----SI--I-A--NS-----------------IG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-FT--ML-----------------------SLTNKNIEK---------------------------------------------AFFIS---------PIVDMEKLITDMM---------------------------FLENITEKELYRKKEIKTSFGETLSWDYLTFARKNPIE-W----NIPTY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-----GEKDK--LTSYETILNFTN-----KSKAHLTIM-----------------------------------------------------------------------------------------------------------KDGEHWFHTDEQMEFLN------NWIK--------------------------------------------- 809
810 ------------------------------------------------V--------------------------IYIH----------------------------------------------------------------------G--------------------K------------------------------------------------------------------------------------------------------------------------------------------YG-----------------------------------------------------------------------------------------------------------------------------------------------------------------TAEEAE-----------------------Y--YR---KFFNETDIIG--FEYTSEYPWDFQ--------------KEFSNFIDNIYIK---------------YKKI----SI--I-A--NS-----------------IG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-FT--ML-----------------------SLTNKNIEK---------------------------------------------AFFIF---------PIVDMEKLITDMM---------------------------FLENITEEELYKKKKIKTSFGETLSWDYLTFTRKNPTE-W----NIPTY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-----GENDD--LTSYETILNFTN-----KSKANLTIM-----------------------------------------------------------------------------------------------------------KGGEHWFHTDEQIEFLD------NWIK--------------------------------------------- 810
811 ---------------------------------------------KKLV--------------------------IYIH----------------------------------------------------------------------G--------------------K------------------------------------------------------------------------------------------------------------------------------------------GG-----------------------------------------------------------------------------------------------------------------------------------------------------------------YADEAN-----------------------H--YE---TLFPDFDVIG--FDYKAETPWDAK--------------QEFSAYFDAVAAN---------------YDEV----ML--I-A--NS-----------------IG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-FS--MN-----------------------ALGEKRIKQ---------------------------------------------ALFIS---------PMVNLEKLICNMM---------------------------LWANVSEDELREKGEIATNFGKTLSWKYLCYVRENPIK-W----NIPTH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-----GSNDN--LTDLETMREFAQ-----KVGASLTIM-----------------------------------------------------------------------------------------------------------QGGEHWFHTDEQMDFLD------RWIEK-------------------------------------------- 811
812 -----------------------------------------------------------------------------MH----------------------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------MSN-----------------------------------------------------------------------------------------------------------------------------------------------KEDK---------IILAFVEEIT-----------------------AKGYQ---VLSFDLPEHG--ERKYKNYPCKVQN-----------CVKDLNIIMDYAETL---------------SNNI----SV--F-A--CS-----------------MG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-FS--LL-----------------------AYSHKFLKK---------------------------------------------SLFLS---------PVVNMEAIINNMM---------------------------TCFGVSEDRLKEEKEISTPIGQTLYWDYYCYVKEHPVITW----NTKAS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-----GEEDD--LCEFQVISAFAR-----RFNCDLEIM-----------------------------------------------------------------------------------------------------------NKAGHYFHTEKQISFLK------NWLRTQI------------------------------------------ 812
813 -------------------------MIRENLKIKNIPAILWGNKSDNLF--------------------------IAVH----------------------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------MSN-----------------------------------------------------------------------------------------------------------------------------------------------KEDK---------IILAFVEEIT-----------------------AKGYQ---VLSFDLPEHG--ERKYKNYPCKVQN-----------CVKDLNIIMDYAETL---------------SNNI----SV--F-A--CS-----------------MG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-FS--LL-----------------------AYSHKFLKQ---------------------------------------------SLFIS---------PVVNMEAIINNMM---------------------------TCFGISEDRLEEEKEISTPVGQILYWDYYCYVKEHPVITW----NTKTS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-----GEDDD--LCEFEVISAFTK-----RFNCDLEIM-----------------------------------------------------------------------------------------------------------NKAGHYFHTEKQISFFK------NWLRTQI------------------------------------------ 813
814 -------------------------MIKQNLKIENIPAILWGNKSDKLF--------------------------VVVH----------------------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------MSN-----------------------------------------------------------------------------------------------------------------------------------------------KADD---------VIVVFAEEAI-----------------------KAGYQ---VLSFDLPEHG--DRKDEAYVCKVQN-----------CVKDLNIIMKYAQAL---------------SNNI----SV--F-A--CS-----------------MG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-FS--LL-----------------------AYSNEPLKQ---------------------------------------------CLFLS---------PVVNMERIINNMM---------------------------TWFNISEEMLKTKQEIKTPIGETLYWDYYCYVKDYPIELW----SKPTS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-----GLQDS--LCEFEVVSEFAK-----RFNCNLQVM-----------------------------------------------------------------------------------------------------------ENGEHYFHTEEQLQFFK------QWVK--------------------------------------------- 814
815 ----------------LYVLFDGGNMLKNNFKISNIPTVLWGDKSEKIF--------------------------IAVH----------------------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------MSN-----------------------------------------------------------------------------------------------------------------------------------------------KEDA---------VIQILAEEAN-----------------------QKGYQ---VLSFDLPEHG--ERKNDNTPCKVQF-----------CISELSIIMNYAKEH---------------WKEV----SV--F-A--CS-----------------IG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-FS--LL-----------------------AYQNDVLKK---------------------------------------------ALLLS---------PVVNMERIIENMM---------------------------KWFNITPELLQKEMTIETPIGQKLYWDYLCYVKEHPINTW----NTDTY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-----GAKDE--LCEFETINYFTK-----KHRCELEVM-----------------------------------------------------------------------------------------------------------ETGEHYFHTEEQLKIFK------QWLNKHID----------------------------------------- 815
816 -------------------------MLKNIFKISNIPAVLWGDKSEKIF--------------------------IAVH----------------------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------MSN-----------------------------------------------------------------------------------------------------------------------------------------------KEDA---------VIQIVAEEAD-----------------------RKGYQ---VLSFDLPEHG--ERKNDNTPCKVQF-----------CVNELSIIMNYAKEH---------------WKEI----NV--F-A--CS-----------------MG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-FS--LL-----------------------AFQNDVIEK---------------------------------------------ALFLS---------PVVNMERIIENMM---------------------------KWFNVTPELLQKEMTIETPIGQKLYWDYLCYVKEHPISTW----NTDTY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-----GAKDE--LCEFETINYFTK-----KHRCELEVM-----------------------------------------------------------------------------------------------------------ETGEHYLHTEEQLKIFE------QWLHKHID----------------------------------------- 816
817 -------------------------MLKDNFNISNIPAVLWGDRSEKVF--------------------------IAVH----------------------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------MSN-----------------------------------------------------------------------------------------------------------------------------------------------KEDT---------VIQKLAEEAN-----------------------QKGYQ---VLSFDLPEHG--ERTNDNTPCKVQV-----------CVSELSIIMNYLKEH---------------WKQV----SV--F-A--CS-----------------IG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-FS--LL-----------------------AYQNDVIEK---------------------------------------------ALFLS---------PVVNMERIIENMM---------------------------KWFNVTPELLQKEMTIETPIGQKLYWDYLCYVKEHPINTW----NIDTY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-----GAKDE--LCEFEIINDFTK-----KHRCELEVM-----------------------------------------------------------------------------------------------------------ETGEHYFHTAEQLKIFE------QWLHKHIN----------------------------------------- 817
818 -------------------------MFKDKFNISNIPTVLWGEKSEKLF--------------------------IAVH----------------------------------------------------------------------G--------------------N------------------------------------------------------------------------------------------------------------------------------------------MSN-----------------------------------------------------------------------------------------------------------------------------------------------KEDT---------VIKILAKEAI-----------------------QKGYQ---VLSFDLPEHG--DRKGDSMPCKVQF-----------CINDLSAIMSYAKKY---------------WSEV----SI--F-A--CS-----------------MG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-FS--LL-----------------------AYKNNMIRK---------------------------------------------ALFLS---------PVVNMEKIIENMM---------------------------MWFNITPERLQKEMTIETPIGQKLYWDYYCYVKQHPINTW----SIDTN----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-----GAKDE--LCEFETINDFVK-----KYCCGLEVM-----------------------------------------------------------------------------------------------------------DTGEHYFHTEEQLNVFQ------HWLRKNID----------------------------------------- 818
819 ---------------------------------------------DKNEYRIKMRDGIHLYTIVYSPKDKSKKYPIILT----RTPYSVGPY---------------------------------------------------------G-----------------------------------------------------------------------------------------------------------------------------------------------------------------EDKFARFLG---PAEQFVKEGYIFVLQDVRGRFMSEGEFDNMRPHKPNKAKNETDESSDTYD----------------------------------------------------------------------------------TIEWLVKN---------------------------------------------------------------------------------------------------------------IPNNNGKV-GM--W-G--NS-----------------YP-----------------------------G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FYT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAID-------------------------------------------------------------------------------------------------------------------------------------------AHPNLAAVSPQAPISDWFI-------------------------------------------------- 819
820 -------------------------------------------------VYITTQDNKKIGAYLLEPECHKDPKKFIVA----L-------H---------------------------------------------------------G--------------------K---------------------------------------------------------------------------------------------------------------GCSREDYVSNSKIHTLVNL---GYCVLVPD---YR--G--------------------------------------------------FADSE-----------------------------------------------------GEFKIDMVNLDIMACFEYLTSRF-DAQE-----------------------------------------------------------------------------------------------------------------------------I-HM--I-G--HS-----------------LGTGIMAEYYRYITKNNIEAKYHPRKMFMISAFTSIIDVGMENVIFRT---INFLVPWIKERVLKEI-------------GYDT-------------------V---------------------------------------------------------------------------------------------------------------------------KNIESAKGR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLYH-----GMKDD--VVPYHHSVTLSKKYGA---KIKL----------------------------------------------------------------------------------------------------------------SDHGHGNILKDE---------------------------------------------------------- 820
821 --------------------------------------KSVTGNVYTYEYKNS----LKMDVYYPSVKR--ESYPFVLF----A-------H---------------------------------------------------------G--------------------G-----------------------------------------------------------------------------------------------------GWISGYRRQPNNVS-WYRFLNANGFAVATFD------------YR-YG-----------------------------------------YFH-YIEDILEDLKSAIS-------------------------------------------------------------------------------FLNEN--------------------------------------------------------------------------------------------------------REHLLI--KN----L-NL--M-G--LS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LVLYHA--MRSSK--------------EGEKDFD--------GN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AWYAPCD--LLD--L----WSMET--SSLFARFSVATTLKGFPVRKKEDYVFYSPV--AWVNPKAPSTMLVH-----GMKDD--VVPYISSVKMYKKLRENGVEAKLRLH-----------------------------------------------------------------------------------------------------------PEGKHGFEFVLKDSLTVKFLYETVSF---------------------------------------------- 821
822 -----------------------------------------EIKADVYRADDN--Q-------T---RP-----V-MVW----F-------H---------------------------------------------------------G--------------------G---------ALIV----------------------------------------GHRGGVS--GRVLQDM--------LNA-GYT-----V----------------------------------------VS------F-D---Y---------------------------------RLAPETK-------L---PEIIAD--LEDG----------------------------------------------F-----------------------------T--WLH---A-KGPELFN------------------------------------V-------DTS--------------------------------------------------------K----V-AV--S-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------C-LTM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VAGY-----------------------------------------------------------------------------------RAK----------------------------------------P------------------------------------------------------------RL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MV-H-----GTKDT--DVPY-EQST-----------LMA-EQ-F-----QQH-----------------GV-------E-------------HELVTI--PN-------------G------------------------------------EHGL-AGGD------------------------------------------------------------ 822
823 --------------------------------------------------------------------P-----T-IVR----F-------H---------------------------------------------------------G--------------------G---------GLVT----------------------------------------NQFEQVMADSIFADFWPQWLSDLALRH-SAI-----V----------------------------------------VS------P-N---Y---------------------------------RLMPQAT-------G---LDIYDD--IEDF----------------------------------------------W-----------------------------T--WLRSP-DFQELLAKHK----------------------------IPTQ---L-------DLD--------------------------------------------------------R----I-LV--T-G--ES-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-LSIN-----------------------------------------ASLTH---------------------------ASEVRA-------------A--IAT------------------------------------------Y-----PSLDPSS-----------------P------------------------------------------------------------DFTQP----------------------------------------------RTDLLPFG---QSLPESLI----------------E---------DVLGP----V--RD-------------------------------------------------G--NPV-SSLVGQEYLPVMCAAIQYGRLGGWYARESQESARQKLLYPVRRLEEPDVQVPVG---------------------------G-------------------------IT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-Q-----GKQDS--VVPA-SHSV-----------PFV-ER-AREVLQGKP-----------------GA-------E------------RISLVLR--DG-------------E-------------------------------------HGF-----------DAEVRYEEQ--------------------------------------------- 823
824 ------------------------------------------PHNPDFVAPEG--E-------L---PP-----L-LVM----I-------H---------------------------------------------------------G--------------------G---------P--T----------------------------------------AAAQPTL--RLSIQYW--------TSR-GIG-----V----------------------------------------LD------V-N---YG--G----ST---------------GFGRAYRELLDGAWG-------V---VDV-ED--CIAG----------------------------------------------A-----------------------------Q--FLA---A-TGR----------------------------------------A-------DPN--------------------------------------------------------R----L-LI--T-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-TVL------------------------------------------AALAF---------------------------HKVFRA-------------G--ASH------------------------------------------F-----GVADLAA-----------------L------------------------------------------------------------ARD---------------------------------------------------THKFE---SRYLDRLV------GPY-PERADLY---------EARSP----L--TH-------------------------------------------------A--DQI-TS--------------------------------------------P------------------------------------------------------------VI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FF-Q-----GLEDK--VVPP-AQSE-----------MMY-EA-L-----RSR-----------------GV-------Y-------------TEYVPF--PG-------------E------------------------------------QHGF-RKAENIITAIERELAFYGN--------------------------------------------- 824
825 ------------------------------GQ--TAHAWYYPPTNGDFRGPSD--A-------L---PP-----L-LVK----S-------H---------------------------------------------------------G--------------------G---------P--T----------------------------------------AAAGNSL--SLKIQYW--------TSR-GFA-----Y----------------------------------------VD------V-N---YG--G----ST---------------GYGRDYRQRLNGQWG-------I---VDV-AD--CVNA----------------------------------------------A-----------------------------R--YLA---D-QGL----------------------------------------V-------DGE--------------------------------------------------------Q----L-AI--S-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-TTL------------------------------------------AALTF---------------------------HNVFKA-------------G--ASY------------------------------------------Y-----GVSDLTA-----------------L------------------------------------------------------------ATD---------------------------------------------------THKFE---ARYLDGLI------GPY-PERKDLY---------ERRSP----V--NH-------------------------------------------------A--DQL-TC--------------------------------------------P------------------------------------------------------------VI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FF-Q-----GLEDK--VVPP-NQTE-----------MMV-QA-L-----KAK-----------------GI-------K-------------VEYVAF--PE-------------E------------------------------------QHGF-RMAANI---------------------------------------------------------- 825
826 SIVWSSSPDVVQYKPFFSTPEFIEFPTSTPGQ--NAYAYFYPPLNPMFQGLPD--E-------R---PP-----L-LVK----T-------H---------------------------------------------------------G--------------------G---------P--T----------------------------------------AEAQGIL--DLSVQYW--------TSR-GWA-----F----------------------------------------LD------V-N---YG--G----ST---------------GYGREYRERLLEKWG-------I---VDV-DD--CCSC----------------------------------------------A-----------------------------R--FLV---E-NGK----------------------------------------V-------DDQ--------------------------------------------------------R----L-CI--T-G--RS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-TTL------------------------------------------ASLAF---------------------------RDTFKA-------------G--ASL------------------------------------------Y-----GVGDLSL-----------------L------------------------------------------------------------RAE---------------------------------------------------THKFE---SHYMDSLV------G----NERAYY---------E-RSP----I--NF-------------------------------------------------V--NKF-TC--------------------------------------------P------------------------------------------------------------VI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LF-Q-----GLDDK--VVPP-DQAR-----------AIY-KA-L-----KEK-----------------GL-------P-------------VALVEY--EG-------------E------------------------------------QHGF-RKAENIKFTLEQQMLFFAR--------------------------------------------- 826
827 EIVWSSSPDVLKYKAYFSVPELIEFPTEVPGQ--NAYAYFYPPTNPLYNASME--E-------K---PP-----L-LVK----S-------H---------------------------------------------------------G--------------------G---------P--T----------------------------------------AESRGSL--NLNIQYW--------TSR-GWA-----F----------------------------------------VD------V-N---YG--G----ST---------------GYGREYRERLLRQWG-------I---VDV-DD--CCGC----------------------------------------------A-----------------------------K--YLV---S-SGK----------------------------------------A-------DVK--------------------------------------------------------R----L-CI--S-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-TTL------------------------------------------ASLAF---------------------------RDVFKA-------------G--ASL------------------------------------------Y-----GVADLKM-----------------L------------------------------------------------------------KEE---------------------------------------------------GHKFE---SRYIDNLV------G----DEKDFY---------E-RSP----I--NF-------------------------------------------------V--DKF-SC--------------------------------------------P------------------------------------------------------------II--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LF-Q-----GLEDK--VVTP-DQSR-----------KIY-EA-L-----KKK-----------------GL-------P-------------VALVEY--EG-------------E------------------------------------QHGF-RKAENIKYTLEQQMVFFAR--------------------------------------------- 827
828 SIIWSSSEDVTKYTSYFSLPEFMEYPTVIPGK--HAYAYFYAPYNHVFQGSSD--E-------K---PP-----L-LVR----T-------H---------------------------------------------------------G--------------------G---------P--T----------------------------------------DEARGVL--DLGVQYW--------TSR-GWA-----L----------------------------------------VD------V-N---YG--G----SA---------------GYGREYRERLSGQWG-------I---VDV-ND--CCSC----------------------------------------------A-----------------------------T--FLV---E-TGR----------------------------------------V-------DGQ--------------------------------------------------------R----L-CV--T-G--ES-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-TTL------------------------------------------ACLAF---------------------------RQTFKA-------------G--SSL------------------------------------------Y-----GIADLAS-----------------L------------------------------------------------------------RKG---------------------------------------------------MHKFE---AHYIDNLV------G----NKQAYF---------E-RSP----I--NF-------------------------------------------------V--ERF-TC--------------------------------------------P------------------------------------------------------------VI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LF-Q-----GLEDP--VVSP-DQAT-----------IIH-RA-I-----KDK-----------------GL-------P-------------VALVEY--EG-------------E------------------------------------QHGF-RKAQNIKFTLEQQMMFFAR--------------------------------------------- 828
829 ------------------------------------------PCNGDYQPPEN--E-------K---PP-----L-IVI----S-------H---------------------------------------------------------G--------------------G---------P--T----------------------------------------SSTSTAL--NLKNQFW--------TSC-GFA-----V----------------------------------------LD------V-N---YG--G----ST---------------GYGKAYRERLKGRWG-------V---VDV-AD--CVNG----------------------------------------------A-----------------------------K--YLV---K-IGK----------------------------------------A-------DPK--------------------------------------------------------R----L-II--R-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-TVF------------------------------------------SALIF---------------------------YDVFAA-------------G--SSY------------------------------------------F-----GVADLES-----------------F------------------------------------------------------------ARD---------------------------------------------------THKFE---SHYLETLV------GKY-PEQKSLY---------DARSP----I--NH-------------------------------------------------A--DRL-SC--------------------------------------------P------------------------------------------------------------II--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-Q-----GLEDK--VVLP-AQAE-----------VMI-AK-M-----KQK-----------------GL-------P-------------YAYVVF--EH-------------E------------------------------------QHGF-RNAKNIKTALESELYFFGK--------------------------------------------- 829
830 -----------------------------------SYGYYYPPQNLDYQGPLE--S-------R---PP-----L-LVK----A-------H---------------------------------------------------------G--------------------G---------P--T----------------------------------------SATSNSL--NLGIQYF--------TSR-GFG-----V----------------------------------------LD------V-N---YR--G----ST---------------GYGKNYRHLLRSKWG-------L---LDV-AD--CCSG----------------------------------------------A-----------------------------Q--YLV---E-TGK----------------------------------------A-------DRR--------------------------------------------------------R----L-CI--D-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-TTL------------------------------------------ACLCF---------------------------HDVFNA-------------G--VSK------------------------------------------Y-----GIGDLAI-----------------L------------------------------------------------------------VAE---------------------------------------------------THKFE---SRYCDRLL------APCTPENQHIF---------DSRSP----M--KH-------------------------------------------------I--DQF-NC--------------------------------------------P------------------------------------------------------------IA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FF-Q-----GDEDK--IVPP-NQAE-----------MMF-NA-I-----KEK-----------------KI-------P-------------CAMVIF--KG-------------E------------------------------------QHGF-RKAENIQMALDGEFYFYSR--------------------------------------------- 830
831 ----KSTKDMPVDTGYFSIPEEITFPTAG-GD--TAHAYFYPPKNKDFTAPEG--T-------L---PP-----L-LVR----A-------H---------------------------------------------------------G--------------------G---------P--T----------------------------------------SSCSSTL--NLNIQYF--------TSR-GVG-----L----------------------------------------LD------V-N---YR--G----ST---------------GYGKTYRNKLRLNWG-------I---HDV-DD--CCHG----------------------------------------------A-----------------------------L--YLA---D-KGK----------------------------------------V-------DRK--------------------------------------------------------R----L-AI--D-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-TTL------------------------------------------AALAF---------------------------RDIFHA-------------G--VSH------------------------------------------Y-----GVGDLEA-----------------L------------------------------------------------------------AKD---------------------------------------------------THKFE---SRYLDTII------GAY-PEMESTY---------KERSP----I--NH-------------------------------------------------V--DKL-SC--------------------------------------------S------------------------------------------------------------IA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LF-Q-----GGEDK--IVPP-NQAE-----------MMF-EA-V-----KNK-----------------GL-------P-------------CAFVLF--PD-------------E------------------------------------QHGF-RKAENMRRALDGEFYFLGR--------------------------------------------- 831
832 -------------KGYFSVPENYTWKTSD-ND--VCYGYLYTPQNKDYSAPEG--T-------L---PP-----L-LVK----A-------H---------------------------------------------------------G--------------------G---------P--T----------------------------------------GYSSNTI--ALGIQYF--------TSR-GFA-----V----------------------------------------LD------V-N---YR--G----SF---------------GFGTAYRNKLKTKWG-------I---YDV-DD--CSSG----------------------------------------------A-----------------------------Q--ALA---D-EGR----------------------------------------V-------DKN--------------------------------------------------------C----L-CI--D-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-TTL------------------------------------------ACLAF---------------------------RTVFKA-------------G--ASH------------------------------------------Y-----GIGDLEA-----------------L------------------------------------------------------------VRD---------------------------------------------------THKFE---SRYIDNLI------APYSAETVKIY---------KERSP----I--NY-------------------------------------------------V--DQL-NC--------------------------------------------A------------------------------------------------------------MA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FF-Q-----GDEDK--IVLP-NQAE-----------MMY-EA-V-----MAK-----------------GL-------P-------------TVLVMF--KG-------------E------------------------------------QHGF-RKAENIQKALDGEFYFFAK--------------------------------------------- 832
833 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K--------------------------------------------------------R----V-AI--R-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-TTL------------------------------------------NALAN---------------------------TDVFTA-------------G--TSL------------------------------------------Y-----GIADLRL-----------------L------------------------------------------------------------SAE---------------------------------------------------THKFE---SRYDARLI------GTE-DPNSELW---------ATRSP----I--TH-------------------------------------------------I--HQI-NA--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-Q-----GEDDK--VVPP-SQAR-----------LMF-DA-L-----KDR-----------------GN-------A-------------VAMKIY--PS-------------E------------------------------------AHGF----------------------------------------------------------------- 833
834 WKSLKASSSSKIPDGYLSVPEAVAYPTQFDGQPATAHMLYYPPVNKDFAYPAG--T-------L---PP-----L-LVK----S-------H---------------------------------------------------------G--------------------G---------P--T----------------------------------------SAAASGL--SPLIQYW--------TSR-GFA-----V----------------------------------------AD------V-D---YG--G----ST---------------GYGTAYRNRLQGRWG-------L---VDV-QD--CAAA----------------------------------------------A-----------------------------E--WAV---S-AGR----------------------------------------V-------DKA--------------------------------------------------------R----L-TI--S-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-TTL------------------------------------------ACLAF---------------------------RKTFSA-------------G--VSL------------------------------------------Y-----GVADLKL-----------------L------------------------------------------------------------AEH---------------------------------------------------THKFE---SRYLDGLL------GPL-PAAEAVY---------AARSP----L--AH-------------------------------------------------A--GDF-SA--------------------------------------------P------------------------------------------------------------VA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FF-Q-----GDQDK--VVPP-EQAV-----------VMH-KA-L-----KDR-----------------GL-------P-------------TALVML--AG-------------E------------------------------------QHG------------------------------------------------------------------ 834
835 ---------------------------------------------KDSSTTTT--P-------P---PP-----L-LVK----S-------H---------------------------------------------------------G--------------------G---------P--T----------------------------------------DRAYSVL--NYEYQYW--------TSR-GFA-----I----------------------------------------LD------V-N---YR--G----SS---------------GFGKRYRKLLNGNWG-------L---YDN-AD--LVNA----------------------------------------------A-----------------------------L--HMV---K-MGL----------------------------------------A-------DKD--------------------------------------------------------K----M-FI--D-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-ATL------------------------------------------CSLTF---------------------------YDIFKG-------------G--CSY------------------------------------------Y-----GVADLET-----------------L------------------------------------------------------------FKE---------------------------------------------------THKFE---SRYQDTLITEMKLDGPN-GEWKRIY---------KDRSP----I--NH-------------------------------------------------L--DLL-KS--------------------------------------------P------------------------------------------------------------IA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LF-H-----GLEDH--VVPY-NQSV-----------LMY-DH-L-----KSK-----------------GI-------P-------------SILELF--PG-------------E------------------------------------GHGF-LSKDNIIKCLEYEYIFFCK--------------------------------------------- 835
836 ------------------------------------------PHSPDRTGPEG--E-------K---PP-----Y-VVW----A-------H---------------------------------------------------------G--------------------G---------P--T----------------------------------------GHAPLVL--DLEIAYF--------TSR-GIG-----V----------------------------------------AE------V-N---YG--G----ST---------------GYGRGYRELLRGQWG-------V---VDV-AD--CAAV----------------------------------------------A-----------------------------S--ALV---E-EGA----------------------------------------A-------DPD--------------------------------------------------------R----L-AV--R-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------W-TTA------------------------------------------ASLTG---------------------------TDVYAC-------------G--TIL------------------------------------------Y-----PILDLEG-----------------W------------------------------------------------------------ATD--------------------------------------------------ETHDFE---SRYLESLV------GPF-AEVPERY---------RERSP----L--HR-------------------------------------------------A--DRL-ST--------------------------------------------P------------------------------------------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-Q-----GLDDV--ICPP-AQCE-----------RFL-AA-L-----DGR-----------------GV-------A-------------HAYIAF--EG-------------E------------------------------------GHGF-RRVETMVRALEAELSLYAQ--------------------------------------------- 836
837 ------------------------------------------PYNPAYAGPNDPSE-------K---PP-----V-VVN----I-------H---------------------------------------------------------G--------------------G---------P--T----------------------------------------AHVSQGL--DWKKQYW--------TTR-GWA-----W----------------------------------------LD------V-N---YR--G----SS---------------GYGRAYIEQLNRNWG-------V---VDV-QD--CINS----------------------------------------------V-----------------------------R--LLSGG-E-HDL----------------------------------------V-------DPK--------------------------------------------------------R----A-VI--R-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-TVL------------------------------------------AVISL---------------------PEKETDRKTFAA-------------A--QAS------------------------------------------Y-----GISDLKK-----------------L------------------------------------------------------------EEF---------------------------------------------------THKFE---SHYLSGLL------GGSSAEVPETY---------AKRSP----I--NS-------------------------------------------------V--SKI-ET--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-Q-----GSADK--VVPP-AQSS-----------SIY-EI-L-----KAK-----------------NN-------D-------------VEYKEY--EG-------------E------------------------------------GHGW-RREDTMRDAIERERAFY----------------------------------------------- 837
838 ---------------------------------------------PAYAGPNDPSE-------K---PP-----V-VVN----I-------H---------------------------------------------------------G--------------------G---------P--T----------------------------------------AHVSQGL--DWKKQYW--------TTR-GWA-----W----------------------------------------LD------V-N---YR--G----SS---------------GYGRAYIEQLNRNWG-------V---VDV-QD--CINS----------------------------------------------V-----------------------------R--LLSGG-E-HDL----------------------------------------V-------DPK--------------------------------------------------------R----A-VI--R-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-TVL------------------------------------------AVISL---------------------PEKETDRKTFAA-------------A--QAS------------------------------------------Y-----GISDLKK-----------------L------------------------------------------------------------EEF---------------------------------------------------THKFE---SHYLSGLL------GGSSAEVPETY---------AKRSP----I--NS-------------------------------------------------V--SKI-ET--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-Q-----GSADK--VVPP-AQSS-----------SIY-EI-L-----KAK-----------------NN-------D-------------VEYKEY--EG-------------E------------------------------------GHGW----------------------------------------------------------------- 838
839 ----------------LEISEPEEFVFKSDGV--NVSGYFYPPKNSAYSAPAG--T-------L---PP-----V-LLL----G-------H---------------------------------------------------------G--------------------G---------P--T----------------------------------------APAQNNL--DLKKQFF--------TSR-GIA-----V----------------------------------------FD------V-N---YR--G----ST---------------GFGTEFRRMLYKNCG-------V---ADR-DD--MLNG----------------------------------------------A-----------------------------K--ALV---E-QGR----------------------------------------V-------DPD--------------------------------------------------------K----I-LI--T-G--SS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LIL------------------------------------------SCLIS---------------------P-----NNVIKA-------------A--VSL------------------------------------------Y-----GVADLLA-----------------L------------------------------------------------------------DED---------------------------------------------------THKLE---KSYNELLI------GKY-PEEAAIY---------QERSP----I--YH-------------------------------------------------I--DKI-RT--------------------------------------------P------------------------------------------------------------IA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-H-----GKEDT--VVPM-NQSV-----------TMF-EK-V-----RSS-----------------GV-------T-------------TALQLY--DG-------------E------------------------------------GHGF-RNGQVIKESTEATFYFLMK--------------------------------------------- 839
840 ----------------LEISEPEEFVFKSDGV--DVSGYFYPPKNCSYSAPAG--T-------L---PP-----V-LLL----G-------H---------------------------------------------------------G--------------------G---------P--T----------------------------------------APAQNNL--DLKKQFF--------TSR-GIA-----V----------------------------------------FD------V-N---YR--G----ST---------------GFGTEFRRMLYKNCG-------V---ADR-DD--MLNG----------------------------------------------A-----------------------------K--ALV---E-QGK----------------------------------------V-------DAE--------------------------------------------------------K----V-LI--T-G--SS-----------------SG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LIL------------------------------------------SCLIS---------------------P-----KNIIKA-------------A--VSV------------------------------------------Y-----GVADLLA-----------------L------------------------------------------------------------DED---------------------------------------------------THKLE---RCYNEMLI------GKY-PEQASIY---------EERSP----I--YH-------------------------------------------------I--DKI-RT--------------------------------------------P------------------------------------------------------------IA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-H-----GREDT--VVPM-SQSI-----------TMY-EK-I-----RAS-----------------GV-------T-------------TALMLF--DG-------------E------------------------------------GHGF-RNGQVIKESTEATFYFLMK--------------------------------------------- 840
841 --------------------------------NTLSHAFFLPPTNPKYSSAPG--E-------L---PP-----L-IIT----I-------H---------------------------------------------------------G--------------------G---------P--T----------------------------------------IHTDPGL--SMMWQYY--------TTR-GYA-----V----------------------------------------AL------L-N---YA--G----SS---------------GYGRAYRKLLNGSWG-------V---LDV-HD--AADC----------------------------------------------A-----------------------------R--YLI---S-EGK----------------------------------------V-------HPS--------------------------------------------------------R----I-GI--T-G--VS-----------------SG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-ATL------------------------------------------QAICM--------------------------FPTLFTG-------------A--VSV------------------------------------------S-----GISDVEA-----------------L------------------------------------------------------------VAE---------------------------------------------------THKFE---SHYAFRLLFDDKVPETE-EEKRKVY---------RERSP----R--FH-------------------------------------------------A--DKI-KA--------------------------------------------K------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-Q-----GTDDE--IVPL-NQAQ-----------AMA-DD-V-----QRS-----------------GG-------V-------------AKLVIF--EG-------------E------------------------------------GHGYPRKAENGLQAKEVEEGWWK---------------------------------------------- 841
842 -SNKVKALLSRHKFGILKIPVTQPSDELSDGGQLPFEAIFVSCE-DSWQK------------------P-----T-ALV----L-------H---------------------------------------------------------G--------------------G---------PHST--------------------------------------------SVSGYSKSSAFL--------TSL-GFN-----L----------------------------------------LI------V-N---YR--G----TP---------------GFGEEALQSLPGKVG-----------SQDVQD--CLTA----------------------------------------------L-----------------------------D--FVIK----E-------------------------------------GL---I-------DAS--------------------------------------------------------K----V-AV--V-G--IS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LAT------------------------------------------HLIGQ------------------------APD--RFAV-------------A--AAR------------------------------------------N-----PVCNLSL-----------------M------------------------------------------------------------IGTTDI-------------------PDWCYAVACGS--------EA----KIDA------------------SETP---SLDHLRLF---------YQKSP----V--AH-------------------------------------------------I--SKV-KV--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ML-L-----GGADL--RVPI-SNGL-----------QYA-RA-L-----RER-----------------GG-------E-------------IKIMLF--SE-------------D------------------------------------IHEINIP------QSDFES-----FLNIGVWFKKH---------------------------------- 842
843 ---------------------------------LPFEAIFVSCE-DSWQK------------------P-----T-ALV----L-------H---------------------------------------------------------G--------------------G---------PHST--------------------------------------------SVSGYSKSSAFL--------TSL-GFN-----L----------------------------------------LI------V-N---YR--G----TP---------------GFGEEALQSLPGKVG-----------SQDVQD--CLTA----------------------------------------------L-----------------------------D--FVIK----E-------------------------------------GL---I-------DAS--------------------------------------------------------K----V-AV--V-G--IS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LAT------------------------------------------HLIGQ------------------------APD--RFAV-------------A--AAR------------------------------------------N-----PVCNLSL-----------------M------------------------------------------------------------IGTTDI-------------------PDWCYAVACGS--------EA----KIDA------------------SETP---SLDHLRLF---------YQKSP----V--AH-------------------------------------------------I--SKV-KV--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ML-L-----GGADL--RVPI-SNGL-----------QYA-RA-L-----RER-----------------GG-------E-------------IKIMLF--SE-------------D------------------------------------IHEINIP------QSDFES-----FLNIGVWFK------------------------------------ 843
844 ---------------------------------LPFEAIFVSCE-DSWQK------------------P-----T-ALV----L-------H---------------------------------------------------------G--------------------G---------PHST--------------------------------------------SVSGYSKSSAFL--------TSL-GFN-----L----------------------------------------LI------V-N---YR--G----TP---------------GFGEEALQSLPGKVG-----------SQDVQD--CLTA----------------------------------------------L-----------------------------D--FVIK----E-------------------------------------GL---I-------DAS--------------------------------------------------------K----V-AV--V-G--IS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LAT------------------------------------------HLIGQ------------------------APD--RFAV-------------A--AAR------------------------------------------N-----PVCNLSL-----------------M------------------------------------------------------------IGTTDI-------------------PDWCYAVACGS--------EA----KIDA------------------SETP---SLDHLRLF---------YQKSP----V--AH-------------------------------------------------I--SKV-KV--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ML-L-----GGADL--RVPI-SNGL-----------QYA-RA-L-----RER-----------------GG-------E-------------IKIMLF--SE-------------D------------------------------------IHEINIP------QSDFES-----FLNIGVWFK------------------------------------ 844
845 -------LLADHKFSLLKIPISNPSDKLPDGAKLPFEAIFVSCK-DSTSS------------------P-----T-VVV----L-------H---------------------------------------------------------G--------------------G---------PHSV--------------------------------------------YPSSYSKSLAFL--------YAQ-GYN-----L----------------------------------------LV------V-N---YR--G----SL---------------GFGEEALQSLPGNIG-----------SQDVND--VLTA----------------------------------------------L-----------------------------D--FVTK----R-------------------------------------GL---I-------DAS--------------------------------------------------------R----V-AV--V-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTT------------------------------------------HLIGQ------------------------APE--TFVA-------------A--AAR------------------------------------------N-----PVCNLSL-----------------M------------------------------------------------------------VGTTDI-------------------PEWCFLEMYGK--------EG----KNCF------------------TESP---SAETLAQF---------YEKSP----I--SH-------------------------------------------------I--SKV-KT--------------------------------------------P------------------------------------------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-L-----GAKDL--RVPV-SNGL-----------QYA-RT-M-----KER-----------------GL-------E-------------TKIIVF--PE-------------D------------------------------------NHGLDKP------QADYES-----FLNIGVWFKKY---------------------------------- 845
846 -------------------------------AKLPFEAIFVSCK-DSTSS------------------P-----T-VVV----L-------H---------------------------------------------------------G--------------------G---------PHSV--------------------------------------------YPSSYSKSLAFL--------YAQ-GYN-----L----------------------------------------LV------V-N---YR--G----SL---------------GFGEEALQSLPGNIG-----------SQDVND--VLTA----------------------------------------------L-----------------------------D--FVTK----R-------------------------------------GL---I-------DAS--------------------------------------------------------R----V-AV--V-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTT------------------------------------------HLIGQ------------------------APE--TFVA-------------A--AAR------------------------------------------N-----PVCNLSL-----------------M------------------------------------------------------------VGTTDI-------------------PEWCFLEMYGK--------EG----KNCF------------------TESP---SAETLAQF---------YEKSP----I--SH-------------------------------------------------I--SKV-KT--------------------------------------------P------------------------------------------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-L-----GAKDL--RVPV-SNGL-----------QYA-RT-M-----KER-----------------GL-------E-------------TKIIVF--PE-------------D------------------------------------NHGLDKP------QADYES-----FLNIGVWFK------------------------------------ 846
847 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QDVKD--CLLA----------------------------------------------V-----------------------------D--HAIE----M-------------------------------------GI---A-------DPS--------------------------------------------------------R----I-TV--L-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTT------------------------------------------HLIGQ------------------------APD--KFVA-------------A--AAR------------------------------------------N-----PVCNMAS-----------------M------------------------------------------------------------VGITDI-------------------PDWCFFEAYGD--------QS----H--Y------------------TEAP---SAEDLSRF---------HQMSP----I--SH-------------------------------------------------I--SKV-KT--------------------------------------------P------------------------------------------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-L-----GTKDL--RVPI-SNGF-----------QYV-RA-L-----KEK-----------------GV-------E-------------VKVLVF--PN-------------D------------------------------------NHPLDRP------QTDYES-----FLNIAVWFNKYC--------------------------------- 847
848 ------------------------------------EAIYVSSS-KSKENGK-----------C---DP-----L-IAV----L-------H---------------------------------------------------------G--------------------G---------PHSV--------------------------------------------SPCSFSRTMAYL--------SSI-GYS-----Q----------------------------------------LI------I-N---YR--G----SL---------------GYGEDALQSLPGKVG-----------SQDVKD--CLLA----------------------------------------------V-----------------------------D--HAIE----M-------------------------------------GI---A-------DPS--------------------------------------------------------R----I-TV--L-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTT------------------------------------------HLIGQ------------------------APD--KFVA-------------A--AAR------------------------------------------N-----PVCNMAS-----------------M------------------------------------------------------------VGITDI-------------------PDWCFFEAYGD--------QS----H--Y------------------TEAP---SAEDLSRF---------HQMSP----I--SH-------------------------------------------------I--SKV-KT--------------------------------------------P------------------------------------------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-L-----GTKDL--RVPI-SNGF-----------QYV-RA-L-----KEK-----------------GV-------E-------------VKVLVF--PN-------------D------------------------------------NHPLDRP------QTDYES-----FLNIAVWFN------------------------------------ 848
849 --------------------------------------------------------------------------L-IVM----P-------H---------------------------------------------------------G--------------------G---------PHSH--------------------------------------------SNASWSPMIAGF--------CSI-GFA-----C----------------------------------------LL------I-N---YR--G----SL---------------GYGNAFVQDLIGYIS-----------EKDVSD--CVQA----------------------------------------------T-----------------------------K--FALNY-LQK--------------------------------------Y---G-------SNL--------------------------------------------------------K----A-VL--F-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTL------------------------------------------HLASR------------------------YKN--LYHV-------------A--TAR------------------------------------------N-----PVTHLVS-----------------L------------------------------------------------------------IDTSDI-------------------PDWCYTES-----------GLADWCEWPL------------------GYLP---NENELTRL---------SNQSP----L--KY-------------------------------------------------L--DKTWSV--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ML-L-----GGKDR--RVPN-SQGL-----------TFC-RK-L-----KAL---------------CPTV-------P-------------CETLLY--PY-------------D------------------------------------SHPLDSP------ACSLDV-----FVDCVNW-------------------------------------- 849
850 --------------------------------------------------------------------------L-IVM----P-------H---------------------------------------------------------G--------------------G---------PHSH--------------------------------------------SNASWSPMIAGF--------CSI-GFA-----C----------------------------------------LL------I-N---YR--G----SL---------------GYGNAFVQDLIGYIS-----------EKDVSD--CVQA----------------------------------------------T-----------------------------K--FALNY-LQK--------------------------------------Y---G-------SNL--------------------------------------------------------K----A-VL--F-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTL------------------------------------------HLASR------------------------YKN--LYHV-------------A--TAR------------------------------------------N-----PVTHLVS-----------------L------------------------------------------------------------IDTSDI-------------------PDWCYTES-----------GLADWCEWPL------------------GYLP---NENELTRL---------SNQSP----L--KY-------------------------------------------------L--DKTWSV--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ML-L-----GGKDR--RVPN-SQGL-----------TFC-RK-L-----KAL---------------CPTV-------P-------------CETLLY--PY-------------D------------------------------------SHPLDSP------ACSLDV-----FVDCVNW-------------------------------------- 850
851 ----------------------------------EYEAILAIPK---DVEQK-----------K---WP-----L-IVF----P-------H---------------------------------------------------------G--------------------G---------PHSV--------------------------------------------HTTDFLLLPAVF--------MLS-GFA-----M----------------------------------------VY------V-N---YR--G----SC---------------GYGDDNIRSLPGRVG-----------DQDVKD--CQEV----------------------------------------------A-----------------------------E--SVIK----L-------------------------------------DQ---I-------DEN--------------------------------------------------------K----V-AV--F-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTA------------------------------------------HLIGQ------------------------YPG--FYKA-------------A--CCR------------------------------------------N-----PATNIAV-----------------K------------------------------------------------------------IATTDI-------------------PDWCYVEA-----------GF----EFTY------------------SSLP---TGEKLTEM---------WKMSP----M--QY-------------------------------------------------V--DKV-ET--------------------------------------------P------------------------------------------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IM-L-----GLEDA--RVPP-KQGE-----------EYY-KQ-L-----RAR-----------------NK-------K-------------ARLIGY--SD-------------N------------------------------------SHPIQTV------EASADS-----CINILDW-------------------------------------- 851
852 -------------------------------GVNEYEAILAIPK---DVEQK-----------K---WP-----L-IVF----P-------H---------------------------------------------------------G--------------------G---------PHSV--------------------------------------------HTTDFLLLPAVF--------MLS-GFA-----M----------------------------------------VY------V-N---YR--G----SC---------------GYGDDNIRSLPGRVG-----------DQDVKD--CQEV----------------------------------------------A-----------------------------E--SVIK----L-------------------------------------DQ---I-------DEN--------------------------------------------------------K----V-AV--F-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTA------------------------------------------HLIGQ------------------------YPG--FYKA-------------A--CCR------------------------------------------N-----PATNIAV-----------------K------------------------------------------------------------IATTDI-------------------PDWCYVEA-----------GF----EFTY------------------SSLP---TGEKLTEM---------WKMSP----M--QY-------------------------------------------------V--DKV-ET--------------------------------------------P------------------------------------------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IM-L-----GLEDA--RVPP-KQGE-----------EYY-KQ-L-----RAR-----------------NK-------K-------------ARLIGY--SD-------------N------------------------------------SHPIQTV------EASADS-----CINILDWFWQHL--------------------------------- 852
853 ----------------------------------EYEAILAIPK---DAEQK-----------K---CP-----L-IVF----P-------H---------------------------------------------------------G--------------------G---------PHSV--------------------------------------------HTTDFLLLPAVF--------MLS-GFA-----M----------------------------------------VY------V-N---YR--G----ST---------------GYGDDSVHSLPGRVG-----------DQDVKD--CQEV----------------------------------------------A-----------------------------E--SVIK----L-------------------------------------DQ---I-------DEN--------------------------------------------------------K----V-AV--F-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTT------------------------------------------HLIGQ------------------------YPG--FYKA-------------A--CCR------------------------------------------N-----PVTNIAG-----------------M------------------------------------------------------------VATTDI-------------------PDWCYVEA-----------GF----DFTH------------------SSLT---TGETLTEM---------WNKSP----M--QY-------------------------------------------------V--DKV-ET--------------------------------------------P------------------------------------------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IM-L-----GLEDA--RVPP-KQGE-----------EYY-KK-L-----RAR-----------------NK-------K-------------ARLIGY--SD-------------N------------------------------------SHPILTV------EASADS-----CINILDW-------------------------------------- 853
854 --------------------------------DLSYECILLQSK-EKSSDGK-----------K---RP-----L-IVF----P-------H---------------------------------------------------------G--------------------G---------PNSV--------------------------------------------FTADFALYNACF--------VRC-GFS-----L----------------------------------------LM------V-N---YR--G----SA---------------GFTQNGIDSLIGRVG-----------DQDVKD--CQGA----------------------------------------------A-----------------------------E--KVIE----M-------------------------------------GL---A-------DRD--------------------------------------------------------R----V-LV--M-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTC------------------------------------------HLIGQ------------------------YPD--FYKA-------------A--VAR------------------------------------------N-----PVINMTS-----------------M------------------------------------------------------------FGSTDI-------------------PDWTYTQI-----------GL----TFDF------------------KSNP---DADIYAEL---------YNRSP----I--RY-------------------------------------------------V--DQV-KT--------------------------------------------P------------------------------------------------------------LM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LA-I-----GAKDQ--RVPP-KQAH-----------EMR-KA-L-----QAR-----------------GV-------Q-------------VRALCY--SE-------------C------------------------------------EHPISEV------KSEADC-----FINMLKWFNEHL--------------------------------- 854
855 ----------------------------PQYEGLDFDAILLRPS-EGPTAQK-----------P----P-----L-VVM----P-------H---------------------------------------------------------G--------------------G---------PHTV--------------------------------------------FSAGWMLYPATL--------CRL-GFA-----V----------------------------------------LL------V-N---YR--G----SL---------------GFGQDSVNSLPGNVG-----------TQDVRD--VQLC----------------------------------------------V-----------------------------E--RVLQ----E-------------------------------------EQ---L-------DAS--------------------------------------------------------R----V-AL--V-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LAC------------------------------------------HLIGQ------------------------FPD--TYRA-------------C--VVR------------------------------------------N-----PVVNIAS-----------------M------------------------------------------------------------LTITDI-------------------PDWCLTEV-----------GV----PYEP------------------NALP---DPAHLTVM---------LQKSP----M--SY-------------------------------------------------I--NQV-RT--------------------------------------------P------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GEDDK--RVPP-AQGL-----------EYY-RA-L-----KAR-----------------GV-------P-------------TRLLWY--PK-------------N------------------------------------NHALAGI------EAEADS-----FMNIVLWLLQ----------------------------------- 855
856 -----------------------------QYEGLDFDAILLRPS-EGPTAQK-----------P----P-----L-VVM----P-------H---------------------------------------------------------G--------------------G---------PHTV--------------------------------------------FSAGWMLYPATL--------CRL-GFA-----V----------------------------------------LL------V-N---YR--G----SL---------------GFGQDSVNSLPGNVG-----------TQDVRD--VQLC----------------------------------------------V-----------------------------E--RVLQ----E-------------------------------------EQ---L-------AAS--------------------------------------------------------R----V-AL--V-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LAC------------------------------------------HLIGQ------------------------FPD--TYRA-------------C--VVR------------------------------------------N-----PVVNIAS-----------------M------------------------------------------------------------LTITDI-------------------PDWCLTEV-----------GV----PYEP------------------NALP---DPAHLTVM---------LQKSP----M--SY-------------------------------------------------I--NQV-RT--------------------------------------------P------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GEDDK--RVPP-AQGL-----------EYY-RA-L-----KAR-----------------GV-------P-------------TRLLWY--PK-------------N------------------------------------NHALAGI------EAEADS-----FMNIVLWL------------------------------------- 856
857 -----------------------------QYEGLDFEAILLRPT-QIPQTGK-----------I----P-----L-VVT----P-------H---------------------------------------------------------G--------------------G---------PHSV--------------------------------------------FTTSWTLYPAVL--------CRM-GFA-----V----------------------------------------LL------V-N---YR--G----SL---------------GFGQDCVDCLPGNVG-----------SQDVKD--VQVC----------------------------------------------V-----------------------------Q--NVLE----E-------------------------------------DP---L-------NPQ--------------------------------------------------------R----V-AL--L-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSC------------------------------------------HLIGQ------------------------YPE--TYKA-------------C--VVR------------------------------------------N-----PVVNIAS-----------------M------------------------------------------------------------VGSTDI-------------------PDWCLTEA-----------GL----EYDQ------------------AALP---DPAQWTKM---------LLHSP----M--QY-------------------------------------------------V--DKV-QA--------------------------------------------P------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-I-----GEDDR--RVPP-KQGL-----------EYY-HA-L-----KAR-----------------GV-------P-------------ARMLWY--PG-------------N------------------------------------NHALSGV------EAESDG-----FMNIALWL------------------------------------- 857
858 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QDVKD--VQFA----------------------------------------------V-----------------------------E--QVLQ----E-------------------------------------EH---F-------DAD--------------------------------------------------------R----V-AL--M-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSC------------------------------------------HLIGQ------------------------YPE--TYRA-------------C--VAR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------MGSTDI-------------------PDWCVVEA-----------GF----PYSS------------------DCLP---DLSVWAEM---------LDKSP----I--KY-------------------------------------------------T--PQV-KT--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GQEDR--RVPF-KQGM-----------EYY-RA-L-----KAR-----------------NV-------P-------------VRLLLY--PK-------------S------------------------------------THALSEV------EVESDS-----FMNAVLW-------------------------------------- 858
859 ----------------------------VQFAGLDFEAILLQPS-NPPDKTQ-----------V----P-----M-VVM----P-------H---------------------------------------------------------G--------------------G---------PHSS--------------------------------------------FVTAWMLFPAML--------CKM-GFA-----V----------------------------------------LL------V-N---YR--G----ST---------------GFGQDSILSLPGKVG-----------HQDVKD--VQFA----------------------------------------------V-----------------------------E--QVLQ----E-------------------------------------EH---F-------DAD--------------------------------------------------------R----V-AL--M-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSC------------------------------------------HLIGQ------------------------YPE--TYRA-------------C--VAR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------MGSTDI-------------------PDWCVVEA-----------GF----PYSS------------------DCLP---DLSVWAEM---------LDKSP----I--KY-------------------------------------------------T--PQV-KT--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GQEDR--RVPF-KQGM-----------EYY-RA-L-----KAR-----------------NV-------P-------------VRLLLY--PK-------------S------------------------------------THALSEV------EVESDS-----FMNAVLWLHT----------------------------------- 859
860 ----------------------------VQFAGLDFEAILLQPS-NPPDKTQ-----------V----P-----M-VVM----P-------H---------------------------------------------------------G--------------------G---------PHSS--------------------------------------------FVTAWMLFPAML--------CKM-GFA-----V----------------------------------------LL------V-N---YR--G----ST---------------GFGQDSILSLPGKVG-----------HQDVKD--VQFA----------------------------------------------V-----------------------------E--QVLQ----E-------------------------------------EH---F-------DAD--------------------------------------------------------R----V-AL--M-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSC------------------------------------------HLIGQ------------------------YPE--TYRA-------------C--VAR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------MGSTDI-------------------PDWCVVEA-----------GF----PYSS------------------DCLP---DLSVWAEM---------LDKSP----I--KY-------------------------------------------------T--PQV-KT--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GQEDR--RVPF-KQGM-----------EYY-RA-L-----KAR-----------------NV-------P-------------VRLLLY--PK-------------S------------------------------------THALSEV------EVESDS-----FMNAVLWLHT----------------------------------- 860
861 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QDVKD--VQFA----------------------------------------------V-----------------------------E--QVLR----E-------------------------------------EH---F-------DAD--------------------------------------------------------R----V-AL--M-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSC------------------------------------------HLIGQ------------------------YPE--TYSA-------------C--VVR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------MGSTDI-------------------PDWCVVEA-----------GF----PYSS------------------DCLP---DVSVWAEM---------LDKSP----I--KY-------------------------------------------------T--PQV-KT--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GQEDR--RVPF-KQGM-----------EYY-RA-L-----KAR-----------------NV-------P-------------VRLLLY--PK-------------S------------------------------------THALSEV------EVESDS-----FMNAVLW-------------------------------------- 861
862 ----------------------------VQYVGLDFEAILLQPS-NPPDKTH-----------V----P-----M-VVM----P-------H---------------------------------------------------------G--------------------G---------PHSS--------------------------------------------FVTAWMLFPAML--------CKM-GFA-----V----------------------------------------LL------V-N---YR--G----ST---------------GFGQDSILSLPGNVG-----------HQDVKD--VQFA----------------------------------------------V-----------------------------E--QVLR----E-------------------------------------EH---F-------DAD--------------------------------------------------------R----V-AL--M-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSC------------------------------------------HLIGQ------------------------YPE--TYSA-------------C--VVR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------MGSTDI-------------------PDWCVVEA-----------GF----PYSS------------------DCLP---DVSVWAEM---------LDKSP----I--KY-------------------------------------------------T--PQV-KT--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GQEDR--RVPF-KQGM-----------EYY-RA-L-----KAR-----------------NV-------P-------------VRLLLY--PK-------------S------------------------------------THALSEV------EVESDS-----FMNAVLWLHT----------------------------------- 862
863 -------------------LQPPPEQENVQYAGLDFEAILLQPS-DPPDKTQ-----------V----P-----M-VVM----P-------H---------------------------------------------------------G--------------------G---------PHSS--------------------------------------------FVTAWMLFPAML--------CKM-GFA-----V----------------------------------------LL------V-N---YR--G----ST---------------GFGQDSILSLPGNVG-----------NQDVKD--VQFA----------------------------------------------V-----------------------------E--QVLQ----E-------------------------------------EH---F-------DAG--------------------------------------------------------R----V-AL--M-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSC------------------------------------------HLIGQ------------------------YPE--TYSA-------------C--VAR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------MGSTDI-------------------PDWCVVEA-----------GF----PYSS------------------DCLP---DLSVWAEM---------LDKSP----I--KY-------------------------------------------------T--PQV-KT--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GQEDR--RVPF-KQGV-----------EYY-RA-L-----KAR-----------------KV-------P-------------VRLLLY--PK-------------S------------------------------------THTLSEV------EVESDS-----FMNAVLW-------------------------------------- 863
864 ----------------------------VQYAGLDFEAILLQPS-DPPDKTQ-----------V----P-----M-VVM----P-------H-------------------------------------------------------------------------------------------------------------------------------------------------AML--------CKM-GFA-----V----------------------------------------LL------V-N---YR--G----ST---------------GFGQDSILSLPGNVG-----------NQDVKD--VQFA----------------------------------------------V-----------------------------E--QVLQ----E-------------------------------------EH---F-------DAG--------------------------------------------------------R----V-AL--M-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSC------------------------------------------HLIGQ------------------------YPE--TYSA-------------C--VAR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------MGSTDI-------------------PDWCVVEA-----------GF----PYSS------------------DCLP---DLSVWAEM---------LDKSP----I--KY-------------------------------------------------T--PQV-KT--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GQEDR--RVPF-KQGV-----------EYY-RA-L-----KAR-----------------KV-------P-------------VRLLLY--PK-------------S------------------------------------THTLSEV------EVESDS-----FMNAVLWLRT----------------------------------- 864
865 -------------------------QENVQYAGLDFEAILLQPG-SPPDKTQ-----------V----P-----M-VVM----P-------H---------------------------------------------------------G--------------------G---------PHSS--------------------------------------------FVTAWMLFPAML--------CKM-GFA-----V----------------------------------------LL------V-N---YR--G----ST---------------GFGQDSILSLPGNVG-----------HQDVKD--VQFA----------------------------------------------V-----------------------------E--QVLQ----E-------------------------------------EH---F-------DAS--------------------------------------------------------H----V-AL--M-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-ISC------------------------------------------HLIGQ------------------------YPE--TYRA-------------C--VAR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------LGSTDI-------------------PDWCVVEA-----------GF----PFSS------------------DCLP---DLSVWAEM---------LDKSP----I--RY-------------------------------------------------I--PQV-KT--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GQEDR--RVPF-KQGM-----------EYY-RA-L-----KTR-----------------NV-------P-------------VRLLLY--PK-------------S------------------------------------THALSEV------EVESDS-----FMNAVLWL------------------------------------- 865
866 ----------------------------VQYAGLDFEAILLQPG-SPPDKTQ-----------V----P-----M-VVM----P-------HGRHLALRALALPALFLAGPFTLRSL------------------------------SAG--------------------G---------PHSS--------------------------------------------FVTAWMLFPAML--------CKM-GFA-----V----------------------------------------LL------V-N---YR--G----ST---------------GFGQDSILSLPGNVG-----------HQDVKD--VQFA----------------------------------------------V-----------------------------E--QVLQ----E-------------------------------------EH---F-------DAS--------------------------------------------------------H----V-AL--M-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-ISC------------------------------------------HLIGQ------------------------YPE--TYRA-------------C--VAR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------LGSTDI-------------------PDWCVVEA-----------GF----PFSS------------------DCLP---DLSVWAEM---------LDKSP----I--RY-------------------------------------------------I--PQV-KT--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GQEDR--RVPF-KQGM-----------EYY-RA-L-----KTR-----------------NV-------P-------------VRLLLY--PK-------------S------------------------------------THALSEV------EVESDS-----FMNAVLWLRT----------------------------------- 866
867 ----------------------------VQYAGLDFEAILLQPG-SPPDKTQ-----------V----P-----M-VVM----P-------HGRHLALRALALPALFLAGPFTLRSL------------------------------SAG--------------------G---------PHSS--------------------------------------------FVTAWMLFPAML--------CKM-GFA-----V----------------------------------------LL------V-N---YR--G----ST---------------GFGQDSILSLPGNVG-----------HQDVKD--VQFA----------------------------------------------V-----------------------------E--QVLQ----E-------------------------------------EH---F-------DAS--------------------------------------------------------H----V-AL--M-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-ISC------------------------------------------HLIGQ------------------------YPE--TYRA-------------C--VAR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------LGSTDI-------------------PDWCVVEA-----------GF----PFSS------------------DCLP---DLSVWAEM---------LDKSP----I--RY-------------------------------------------------I--PQV-KT--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GQEDR--RVPF-KQGM-----------EYY-RA-L-----KTR-----------------NV-------P-------------VRLLLY--PK-------------S------------------------------------THALSEV------EVESDS-----FMNAVLWLRT----------------------------------- 867
868 ----------------------------VQYAGLDFEAILLQPG-SPPDKTQ-----------V----P-----M-VVM----P-------H---------------------------------------------------------G--------------------G---------PHSS--------------------------------------------FVTAWMLFPAML--------CKM-GFA-----V----------------------------------------LL------V-N---YR--G----ST---------------GFGQDSILSLPGNVG-----------HQDVKD--VQFA----------------------------------------------V-----------------------------E--QVLQ----E-------------------------------------EH---F-------DAS--------------------------------------------------------H----V-AL--M-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-ISC------------------------------------------HLIGQ------------------------YPE--TYRA-------------C--VAR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------LGSTDI-------------------PDWCVVEA-----------GF----PFSS------------------DCLP---DLSVWAEM---------LDKSP----I--RY-------------------------------------------------I--PQV-KT--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GQEDR--RVPF-KQGM-----------EYY-RA-L-----KTR-----------------NV-------P-------------VRLLLY--PK-------------S------------------------------------THALSEV------EVESDS-----FMNAVLWLRT----------------------------------- 868
869 ----------------------------VQYAGLDFEAILLQPG-SPPDKTQ-----------V----P-----M-VVM----P-------H---------------------------------------------------------G--------------------G---------PHSS--------------------------------------------FVTAWMLFPAML--------CKM-GFA-----V----------------------------------------LL------V-N---YR--G----ST---------------GFGQDSILSLPGNVG-----------HQDVKD--VQFA----------------------------------------------V-----------------------------E--QVLQ----E-------------------------------------EH---F-------DAS--------------------------------------------------------H----V-AL--M-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-ISC------------------------------------------HLIGQ------------------------YPE--TYRA-------------C--VAR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------LGSTDI-------------------PDWCVVEA-----------GF----PFSS------------------DCLP---DLSVWAEM---------LDKSP----I--RY-------------------------------------------------I--PQV-KT--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GQEDR--RVPF-KQGM-----------EYY-RA-L-----KTR-----------------NV-------P-------------VRLLLY--PK-------------S------------------------------------THALSEV------EVESDS-----FMNAVLWLRT----------------------------------- 869
870 ----------------------------VQYAGLDFEAILLQPG-SPPDKTQ-----------V----P-----M-VVM----P-------H---------------------------------------------------------G--------------------G---------PHSS--------------------------------------------FVTAWMLFPAML--------CKM-GFA-----V----------------------------------------LL------V-N---YR--G----ST---------------GFGQDSILSLPGNVG-----------HQDVKD--VQFA----------------------------------------------V-----------------------------E--QVLQ----E-------------------------------------EH---F-------DAS--------------------------------------------------------H----V-AL--M-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-ISC------------------------------------------HLIGQ------------------------YPE--TYRA-------------C--VAR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------LGSTDI-------------------PDWCVVEA-----------GF----PFSS------------------DCLP---DLSVWAEM---------LDKSP----I--RY-------------------------------------------------I--PQV-KT--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GQEDR--RVPF-KQGM-----------EYY-RA-L-----KTR-----------------NV-------P-------------VRLLLY--PK-------------S------------------------------------THALSEV------EVESDS-----FMNAVLWLRT----------------------------------- 870
871 ----------------------------VQYAGLDFEAILLQPG-SPPDKTQ-----------V----P-----M-VVM----P-------H---------------------------------------------------------G--------------------G---------PHSS--------------------------------------------FVTAWMLFPAML--------CKM-GFA-----V----------------------------------------LL------V-N---YR--G----ST---------------GFGQDSILSLPGNVG-----------HQDVKD--VQFA----------------------------------------------V-----------------------------E--QVLQ----E-------------------------------------EH---F-------DAS--------------------------------------------------------H----V-AL--M-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-ISC------------------------------------------HLIGQ------------------------YPE--TYRA-------------C--VAR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------LGSTDI-------------------PDWCVVEA-----------GF----PFSS------------------DCLP---DLSVWAEM---------LDKSP----I--RY-------------------------------------------------I--PQV-KT--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GQEDR--RVPF-KQGM-----------EYY-RA-L-----KTR-----------------NV-------P-------------VRLLLY--PK-------------S------------------------------------THALSEV------EVESDS-----FMNAVLWLRT----------------------------------- 871
872 ----------------------------VQYAGLDFEAILLQPG-SPPDKTQ-----------V----P-----M-VVM----P-------H---------------------------------------------------------G--------------------G---------PHSS--------------------------------------------FVTAWMLFPAML--------CKM-GFA-----V----------------------------------------LL------V-N---YR--G----ST---------------GFGQDSILSLPGNVG-----------HQDVKD--VQFA----------------------------------------------V-----------------------------E--QVLQ----E-------------------------------------EH---F-------DAS--------------------------------------------------------H----V-AL--M-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-ISC------------------------------------------HLIGQ------------------------YPE--TYRA-------------C--VAR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------LGSTDI-------------------PDWCVVEA-----------GF----PFSS------------------DCLP---DLSVWAEM---------LDKSP----I--RY-------------------------------------------------I--PQV-KT--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GQEDR--RVPF-KQGM-----------EYY-RA-L-----KTR-----------------NV-------P-------------VRLLLY--PK-------------S------------------------------------THALSEV------EVESDS-----FMNAVLWLRT----------------------------------- 872
873 -------------------------QENVQYADLDFEAILLQPS-NSPDKSQ-----------V----P-----M-VVM----P-------H---------------------------------------------------------G--------------------G---------PHSS--------------------------------------------FVTAWMLFPAML--------CKM-GFA-----V----------------------------------------LL------V-N---YR--G----ST---------------GFGQDSILSLPGNVG-----------HQDVKD--VQFA----------------------------------------------V-----------------------------Q--QVLQ----E-------------------------------------EH---F-------DAR--------------------------------------------------------R----V-AL--M-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSC------------------------------------------HLIGQ------------------------YPE--TYSA-------------C--IAR------------------------------------------N-----PVINIVS-----------------M------------------------------------------------------------MGTTDI-------------------PDWCMVET-----------GF----PYSN------------------DYLP---DLNVLEEM---------LDKSP----I--KY-------------------------------------------------I--PQV-KT--------------------------------------------P------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GQEDR--RVPF-KQGL-----------EYY-HA-L-----KAR-----------------NV-------P-------------VRLLLY--PK-------------S------------------------------------THALSEV------EVESDS-----FMNTVLWLHTHL--------------------------------- 873
874 ----------------------------VQYADLDFEAILLQPS-NSPDKSQ-----------V----P-----M-VVM----P-------H---------------------------------------------------------G--------------------G---------PHSS--------------------------------------------FVTAWMLFPAML--------CKM-GFA-----V----------------------------------------LL------V-N---YR--G----ST---------------GFGQDSILSLPGNVG-----------HQDVKD--VQFA----------------------------------------------V-----------------------------Q--QVLQ----E-------------------------------------EH---F-------DAR--------------------------------------------------------R----V-AL--M-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSC------------------------------------------HLIGQ------------------------YPE--TYSA-------------C--IAR------------------------------------------N-----PVINIVS-----------------M------------------------------------------------------------MGTTDI-------------------PDWCMVET-----------GF----PYSN------------------DYLP---DLNVLEEM---------LDKSP----I--KY-------------------------------------------------I--PQV-KT--------------------------------------------P------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GQEDR--RVPF-KQGL-----------EYY-HA-L-----KAR-----------------NV-------P-------------VRLLLY--PK-------------S------------------------------------THALSEV------EVESDS-----FMNTVLWLHT----------------------------------- 874
875 ----------------------------VQYADLDFEAILLQPS-NSPDKSQ-----------V----P-----M-VVM----P-------H---------------------------------------------------------G--------------------G---------PHSS--------------------------------------------FVTAWMLFPAML--------CKM-GFA-----V----------------------------------------LL------V-N---YR--G----ST---------------GFGQDSILSLPGNVG-----------HQDVKD--VQFA----------------------------------------------V-----------------------------Q--QVLQ----E-------------------------------------EH---F-------DAR--------------------------------------------------------R----V-AL--M-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSC------------------------------------------HLIGQ------------------------YPE--TYSA-------------C--IAR------------------------------------------N-----PVINIVS-----------------M------------------------------------------------------------MGTTDI-------------------PDWCMVET-----------GF----PYSN------------------DYLP---DLNVLEEM---------LDKSP----I--KY-------------------------------------------------I--PQV-KT--------------------------------------------P------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GQEDR--RVPF-KQGL-----------EYY-HA-L-----KAR-----------------NV-------P-------------VRLLLY--PK-------------S------------------------------------THALSEV------EVESDS-----FMNTVLWLHT----------------------------------- 875
876 ----------------------------AQYVGLDFEAILIQPS-NPPDKTQ-----------V----P-----M-VVM----P-------H---------------------------------------------------------G--------------------G---------PHSS--------------------------------------------FVTSWMLLPAML--------CKM-GFA-----A----------------------------------------LL------V-N---YR--G----ST---------------GFGQDSILSLPGNVG-----------SQDVKD--VQFA----------------------------------------------V-----------------------------E--QVLQ----E-------------------------------------EH---F-------DAG--------------------------------------------------------R----V-AL--L-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSC------------------------------------------HLIGQ------------------------YPE--TYGA-------------C--VVR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------MGSTDI-------------------PDWCVVEA-----------GY----LYSS------------------DCLP---DPNVWSEM---------LNKSP----I--KY-------------------------------------------------T--PQV-KT--------------------------------------------P------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GQEDR--RVPF-KQGM-----------EYY-RA-L-----KAR-----------------NV-------P-------------VRLLLY--PK-------------S------------------------------------THSLSEV------EVESDS-----FMNAVIWMCT----------------------------------- 876
877 -----------------------------QYVGLDFEAILIQPS-NPPDKTQ-----------V----P-----M-VVM----P-------H---------------------------------------------------------G--------------------G---------PHSS--------------------------------------------FVTSWMLLPAML--------CKM-GFA-----A----------------------------------------LL------V-N---YR--G----ST---------------GFGQDSILSLPGNVG-----------SQDVKD--VQFA----------------------------------------------V-----------------------------E--QVLQ----E-------------------------------------EH---F-------DAG--------------------------------------------------------R----V-AL--L-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSC------------------------------------------HLIGQ------------------------YPE--TYGA-------------C--VVR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------MGSTDI-------------------PDWCVVEA-----------GY----LYSS------------------DCLP---DPNVWSEM---------LNKSP----I--KY-------------------------------------------------T--PQV-KT--------------------------------------------P------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GQEDR--RVPF-KQGM-----------EYY-RA-L-----KAR-----------------NV-------P-------------VRLLLY--PK-------------S------------------------------------THSLSEV------EVESDS-----FMNAVIWMCT----------------------------------- 877
878 ----------------------------TQYPGLDFDALLLKPK-DTPADGK-----------L----P-----L-IVM----P-------H---------------------------------------------------------G--------------------G---------PHSV--------------------------------------------LLSEWILSTAVL--------CKM-GFS-----L----------------------------------------LL------V-N---YR--G----SL---------------GFGQDNVFSLPGLIG-----------TQDVKD--VQFA----------------------------------------------V-----------------------------D--SVLK----Q-------------------------------------GG---F-------DEQ--------------------------------------------------------K----V-AV--I-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LAC------------------------------------------HLIGQ------------------------YPG--FYKA-------------C--VAR------------------------------------------N-----PVINLTS-----------------M------------------------------------------------------------VGGTDI-------------------PDWCTVEA-----------GY----KYKP------------------DVYL---EPAVLVQM---------LIKKK----I--KH-------------------------------------------------V--AKV-KT--------------------------------------------P------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-L-----GEDDK--RVPN-KQGI-----------EYY-RA-L-----KNL-----------------QV-------P-------------VRVLWY--PG-------------N------------------------------------NHSLLKV------DAESDG-----FMNGALWIIQ----------------------------------- 878
879 -----------------------------------FDALLLKPK-DTPADGK-----------L----P-----L-IVM----P-------H---------------------------------------------------------G--------------------G---------PHSV--------------------------------------------LVSEWILSTAVL--------CKM-GFS-----V----------------------------------------LL------V-N---YR--G----SL---------------GFGQDNVFSLPGNCG-----------TQDVKD--VQFA----------------------------------------------V-----------------------------D--SVLK----Q-------------------------------------GG---F-------DEQ--------------------------------------------------------K----V-AV--I-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LAC------------------------------------------HLIGQ------------------------YPG--FYKA-------------C--VAR------------------------------------------N-----PVTNLAS-----------------M------------------------------------------------------------VCCTDI-------------------PDWCIVEA-----------GF----DYKP------------------DIQL---EPAILEQM---------LIKSP----I--KH-------------------------------------------------V--AKV-KT--------------------------------------------P------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GEGDK--RVPN-KQGI-----------EYY-KA-L-----KSL-----------------QV-------P-------------VRVLWY--PG-------------N------------------------------------NHSLSKV------DAESDG-----FMNGALWMIQHLSL------------------------------- 879
880 -----------------------------QFSGLNFGAILLKPY-SPPERRK-----------T----P-----L-VVN----I-------H---------------------------------------------------------G--------------------G---------PHAH--------------------------------------------FAADWNATAAAL--------TKL-GFA-----V----------------------------------------LM------V-N---YR--G----ST---------------GFGQDSIESLLGNVG-----------SQDVKD--VQRA----------------------------------------------V-----------------------------L--CALQ---NE-------------------------------------TT---L-------DPD--------------------------------------------------------R----V-VV--M-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LAC------------------------------------------HLIGQ------------------------YPD--FYRA-------------C--AAR------------------------------------------N-----PVINAAT-----------------L------------------------------------------------------------LGTSDI-------------------VDWRYSSV-----------GL----QYAF------------------DRLP---TSQSLISM---------LDKSP----I--IH-------------------------------------------------A--PQI-RA--------------------------------------------P------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GGRDR--RVSP-HQGL-----------ELY-RA-L-----KSR-----------------NT-------P-------------VRLLWF--SD-------------E------------------------------------GHTLSKV------NTQSDC-----FLNILLWFK------------------------------------ 880
881 ----------------------------HQFSGLNFGAILLKPY-SPPERRK-----------T----P-----L-VVN----I-------H---------------------------------------------------------G--------------------G---------PHAH--------------------------------------------FAADWNATAAAL--------TKL-GFA-----V----------------------------------------LM------V-N---YR--G----ST---------------GFGQDSIESLLGNVG-----------SQDVKD--VQRA----------------------------------------------V-----------------------------L--CALQ---NE-------------------------------------TT---L-------DPD--------------------------------------------------------R----V-VV--M-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LAC------------------------------------------HLIGQ------------------------YPD--FYRA-------------C--AAR------------------------------------------N-----PVINAAT-----------------L------------------------------------------------------------LGTSDI-------------------VDWRYSSV-----------GL----QYAF------------------DRLP---TSQSLISM---------LDKSP----I--IH-------------------------------------------------A--PQI-RA--------------------------------------------P------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GGRDR--RVSP-HQGL-----------ELY-RA-L-----KSR-----------------NT-------P-------------VRLLWF--SD-------------E------------------------------------GHTLSKV------NTQSDC-----FLNILLWFKE----------------------------------- 881
882 -----------------------------------FEALLLSPT-GGTTPH-----------------P-----L-VVC----P-------H---------------------------------------------------------G--------------------G---------PHAV--------------------------------------------FDARWRPSMAAL--------CWL-GFA-----M----------------------------------------LL------V-N---YR--G----SL---------------GFGQASIECLQSRMG-----------EQDVAD--TQLA----------------------------------------------V-----------------------------E--QALR----Y-------------------------------------EP---L-------DPH--------------------------------------------------------R----V-AL--L-A--GS-----------------HG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-IAL------------------------------------------HLLTR------------------------QPE--RYQA-------------C--ALR------------------------------------------N-----PVSNLPA-----------------L------------------------------------------------------------LGTSDI-------------------PDWRYTSL-----------GL----PYSF------------------QRVP---HVEDLVVM---------LQRSP----I--IQ-------------------------------------------------A--PRV-RA--------------------------------------------P------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LC-V-----GARDR--RVSP-TQAL-----------ELY-RV-L-----RAH-----------------RV-------P-------------TRLLWY--PE-------------G------------------------------------GHALTGV------ETEADV-----FGNCARWF------------------------------------- 882
883 -----------------------------------FEALLLSPT-GGTTPH-----------------P-----L-VVC----P-------H---------------------------------------------------------G--------------------G---------PHAV--------------------------------------------FDARWRPSMAAL--------CWL-GFA-----M----------------------------------------LL------V-N---YR--G----SL---------------GFGQASIECLQSRMG-----------EQDVAD--TQLA----------------------------------------------V-----------------------------E--QALR----Y-------------------------------------EP---L-------DPH--------------------------------------------------------R----V-AL--L-A--GS-----------------HG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-IAL------------------------------------------HLLTR------------------------QPE--RYQA-------------C--ALR------------------------------------------N-----PVSNLPA-----------------L------------------------------------------------------------LGTSDI-------------------PDWRYTSL-----------GL----PYSF------------------QRVP---HVEDLVVM---------LQRSP----I--IQ-------------------------------------------------A--PRV-RA--------------------------------------------P------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LC-V-----GARDR--RVSP-TQAL-----------ELY-RV-L-----RAH-----------------RV-------P-------------TRLLWY--PE-------------G------------------------------------GHALTGV------ETEADV-----FGNCARWF------------------------------------- 883
884 -----------------------------------------------------------------------------------------------------------------------------------------------------G--------------------G---------PHAV--------------------------------------------FDARWRPSMAAL--------CWL-GFA-----M----------------------------------------LL------V-N---YR--G----SL---------------GFGQASIECLQSRMG-----------EQDVAD--TQLA----------------------------------------------V-----------------------------E--QALR----Y-------------------------------------EP---L-------DPH--------------------------------------------------------R----V-AL--L-A--GS-----------------HG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-IAL------------------------------------------HLLTR------------------------QPE--RYQA-------------C--ALR------------------------------------------N-----PVSNLPA-----------------L------------------------------------------------------------LGTSDI-------------------PDWRYTSL-----------GL----PYSF------------------QRVP---HVEDLVVM---------LQRSP----I--IQ-------------------------------------------------A--PRV-RA--------------------------------------------P------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LC-V-----GARDR--RVSP-TQAL-----------ELY-RV-L-----RAH-----------------RV-------P-------------TRLLWY--PE-------------G------------------------------------GHALTGV------ETEADV-----FGNCARW-------------------------------------- 884
885 ------------------------------YTDQTFEAVLLSPQ-VSKEREK-----------T---FP-----L-IVS----P-------H---------------------------------------------------------G--------------------G---------PHAV--------------------------------------------FDACWHPTMACL--------CQL-GFA-----V----------------------------------------LM------V-N---YR--G----SL---------------GFGQASIDSLISHVG-----------VQDVED--TQLA----------------------------------------------V-----------------------------E--IALQ----I-------------------------------------GT---L-------DPK--------------------------------------------------------R----I-AL--F-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-ICC------------------------------------------HLIGR------------------------YPD--MYKA-------------C--AVR------------------------------------------S-----PVINMAT-----------------L------------------------------------------------------------LGTSDI-------------------PDWRYSAL-----------GL----PYFS------------------DQIP---TEVDLATM---------LLSSP----I--IH-------------------------------------------------A--AKV-QA--------------------------------------------P------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LC-V-----GAKDR--RVSP-CQAL-----------EYY-RV-L-----RAR-----------------GV-------P-------------VRLLWY--PE-------------E------------------------------------NHVISGV------EAKADV-----FINCAQWI------------------------------------- 885
886 --------------------------------------------------------------------P-----L-VVV----P-------H---------------------------------------------------------G--------------------G---------PHGV--------------------------------------------MPTAFVPSYAFL--------SATQGFA-----V----------------------------------------LH------V-N---FR--G----ST---------------GFGTTALESLPGRIG-----------KQDVAD--VVAA----------------------------------------------T-----------------------------K--AALAL-EPE-------------------------------------AL-----------DAA--------------------------------------------------------R----V-GV--V-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LGA------------------------------------------HLTAQ------------------------HPE--IFKA-------------T--ALR------------------------------------------N-----PVTNIAS-----------------M------------------------------------------------------------VTVSDI-------------------PDWCYVEALG-------CGKY----NFDA------------------FKTP---TAEDLHEM---------WKASP----V--AH-------------------------------------------------I--DGV-VA--------------------------------------------P------------------------------------------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VA-L-----GAKDR--RVPH-SQGL-----------EWF-HA-L-----RSR-----------------GV-------K-------------TKLLVY--PE-------------D------------------------------------VHAIDMP------ASEADQ-----WLNIVGWLKKH---------------------------------- 886
887 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YA-----I----------------------------------------LM------V-N---YR--G----ST---------------GFGQDSIESLPTRIG-----------ELDVKD--VIAA----------------------------------------------T----------------------------------LKV-QES-------------------------------------GI---V-------DAE--------------------------------------------------------R----I-GI--C-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTG------------------------------------------HCTSQ------------------------YPN--LFKA-------------A--AMR------------------------------------------N-----PVVNIPS-----------------M------------------------------------------------------------VTSTDI-------------------PDWCYVEAIG---------SY----NWRE------------------YMPP---TSTSIRMM---------WDKSP----I--RH-------------------------------------------------V--DRV-QT--------------------------------------------P------------------------------------------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VA-L-----GMQDL--RVPP-SQGL-----------EWY-HS-L-----RSK-----------------GV-------P-------------TKLLTY--DG-------------N------------------------------------DHAIAGV------KAEADH-----WVNIKQWFDNH---------------------------------- 887
888 ------------------------LRVVPRVGGNRDPFDCLIWM-PRQRTGP-----------L----P-----A-VVA----P-------H---------------------------------------------------------G--------------------G---------PHTA--------------------------------------------VTLGWYPAYAYL--------VAL-GYA-----V----------------------------------------VV------P-N---YR--G----ST---------------GYGQAALASLPGAIG-----------RNDVDD--CVAS----------------------------------------------V-----------------------------E--AAVA----E-------------------------------------GL---V-------DKS--------------------------------------------------------R----V-SV--V-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTA------------------------------------------HLLGQ------------------------HPA--AFRS-------------G--VMR------------------------------------------N-----PVTNISA-----------------M------------------------------------------------------------IAASDI-------------------PDWCYVEALGSEAGRQRCG-----------------------------PVP---SPEDLAAM---------YAASP----V--VY-------------------------------------------------V--DAV-KA--------------------------------------------P------------------------------------------------------------VF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MM-L-----GAKDR--RVPP-PDGL-----------QYL-SA-L-----RGR-----------------DVAAHGAPPE-------------SRLIVF--PE-------------D------------------------------------SHGLDKP------QTEFEQ-----WINVVWWLKRF---------------------------------- 888
889 ---------------------------------------------------------------L----P-----A-VVA----P-------H---------------------------------------------------------G--------------------G---------PHTA--------------------------------------------VTLGWYPAYAYL--------VAL-GYA-----V----------------------------------------VV------P-N---YR--G----ST---------------GYGQAALASLPGAIG-----------RNDVDD--CVAS----------------------------------------------V-----------------------------E--AAVA----E-------------------------------------GL---V-------DKS--------------------------------------------------------R----V-SV--V-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTA------------------------------------------HLLGQ------------------------HPA--AFRS-------------G--VMR------------------------------------------N-----PVTNISA-----------------M------------------------------------------------------------IAASDI-------------------PDWCYVEALGSEAGRQRCG-----------------------------PVP---SPEDLAAM---------YAASP----V--VY-------------------------------------------------V--DAV-KA--------------------------------------------P------------------------------------------------------------VF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MM-L-----GAKDR--RVPP-PDGL-----------QYL-SA-L-----RGR-----------------DVAAHGAPPE-------------SRLIVF--PE-------------D------------------------------------SHGLDKP------QTEFEQ-----WINVVWWLK------------------------------------ 889
890 -------------------------------SDIDFETIIVKPKGNSGGQEK-----------K---PP-----L-IVW----A-------H---------------------------------------------------------G--------------------G---------PHCV--------------------------------------------ISTGYLLLPGLF--------CQL-GFV-----I----------------------------------------AC------V-N---YR--G----SL---------------GFGQASIDSLPGFIG-----------INDVKD--IQAA----------------------------------------------A-----------------------------E--AVIE----Q-------------------------------------GL---A-------DPD--------------------------------------------------------R----V-AV--Y-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-LAM------------------------------------------HMTAQ------------------------YPD--FYKA-------------C--ITR------------------------------------------N-----PVTNLAA-----------------M------------------------------------------------------------LGGTDI-------------------PSWTMTEA-----------GI----DFDF------------------KKAP---SAEMYAKM---------FNCSP----M--AH-------------------------------------------------I--DKV-RA--------------------------------------------P------------------------------------------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-L-----GSDDL--RVPP-QQGI-----------RYH-QM-L-----KAR-----------------GV-------K-------------TRLLMY--TN-------------N------------------------------------SHPINKV------DAEADR-----LMNMYTWI------------------------------------- 890
891 -------------------------------SDIDFETIIVKPKGNSGGQEK-----------K---PP-----L-IVW----A-------H---------------------------------------------------------G--------------------G---------PHCV--------------------------------------------ISTGYLLLPGLF--------CQL-GFV-----I----------------------------------------AC------V-N---YR--G----SL---------------GFGQASIDSLPGFIG-----------INDVKD--IQAA----------------------------------------------A-----------------------------E--AVIE----Q-------------------------------------GL---A-------DPD--------------------------------------------------------R----V-AV--Y-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-LAM------------------------------------------HMTAQ------------------------YPD--FYKA-------------C--ITR------------------------------------------N-----PVTNLAA-----------------M------------------------------------------------------------LGGTDI-------------------PSWTMTEA-----------GI----DFDF------------------KKAP---SAEMYAKM---------FNCSP----M--AH-------------------------------------------------I--DKV-RA--------------------------------------------P------------------------------------------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-L-----GSDDL--RVPP-QQGI-----------RYH-QM-L-----KAR-----------------GV-------K-------------TRLLMY--TN-------------N------------------------------------SHPINKV------DAEADR-----LMNMYTWITEHL--------------------------------- 891
892 -------------------------------SDIDFETIILKPKANLGSQEK-----------K---LP-----L-IVW----A-------H---------------------------------------------------------G--------------------G---------PHSV--------------------------------------------FSTGYLLLPGLF--------CQL-GFV-----I----------------------------------------AC------V-N---YR--G----SI---------------GFGQASIDSLPGLVG-----------TNDVKD--VQAA----------------------------------------------A-----------------------------E--AVIE----Q-------------------------------------GL---V-------DRE--------------------------------------------------------R----V-AV--S-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LST------------------------------------------HMIGQ------------------------YPD--FYKA-------------C--VTR------------------------------------------N-----PVTNLAA-----------------M------------------------------------------------------------LGGTDI-------------------PSWTMTEA-----------GI----DFDF------------------KIAP---SAEMYAKM---------FNCSP----M--AH-------------------------------------------------I--DKV-KA--------------------------------------------P------------------------------------------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GSDDL--RVPP-QQGI-----------RYH-EM-L-----KAR-----------------GV-------K-------------TRLLMY--PD-------------N------------------------------------SHPINKV------DAEADC-----FMNMYTWITE----------------------------------- 892
893 -------------------------------SDIDFETIILKPKANLGSQEK-----------K---LP-----L-IVW----A-------H---------------------------------------------------------G--------------------G---------PHSV--------------------------------------------FSTGYLLLPGLF--------CQL-GFV-----I----------------------------------------AC------V-N---YR--G----SI---------------GFGQASIDSLPGLVG-----------TNDVKD--VQAA----------------------------------------------A-----------------------------E--AVIE----Q-------------------------------------GL---V-------DRE--------------------------------------------------------R----V-AV--S-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LST------------------------------------------HMIGQ------------------------YPD--FYKA-------------C--VTR------------------------------------------N-----PVTNLAA-----------------M------------------------------------------------------------LGGTDI-------------------PSWTMTEA-----------GI----DFDF------------------KIAP---SAEMYAKM---------FNCSP----M--AH-------------------------------------------------I--DKV-KA--------------------------------------------P------------------------------------------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GSDDL--RVPP-QQGI-----------RYH-EM-L-----KAR-----------------GV-------K-------------TRLLMY--PD-------------N------------------------------------SHPINKV------DAEADC-----FMNMYTWITEHL--------------------------------- 893
894 ----------------------------NDFPGLTFESILLKPT-----HTP-----------I---KG-----L-VVN----P-------H---------------------------------------------------------G--------------------G---------PHGC--------------------------------------------YPTSFDLQSAAL--------CKL-GFA-----V----------------------------------------SR------I-N---YR--G----ST---------------GFGQNSIFSLPGNIS-----------KQDVFD--VQQV----------------------------------------------A-----------------------------E--FVSE-------------------------------------------R---L-------NTG--------------------------------------------------------V----R-FI--T-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTL------------------------------------------QLIGQ------------------------FPD--YYSA-------------A--AAR------------------------------------------N-----PVTNIAS-----------------I------------------------------------------------------------VGVSDI-------------------RDWAFCVA-----------GC----KFTY------------------DACV---TSDMYNTM---------LTVSP----I--MH-------------------------------------------------V--DDV-KT--------------------------------------------P------------------------------------------------------------VM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IM-L-----GEADL--RVPI-SQSH-----------EYA-RM-L-----RAR-----------------GK-------T-------------VRLFQY--KD-------------N------------------------------------NHPISNV------KDEADC-----FVNILSWFNN----------------------------------- 894
895 --------------------------------GLTFESILLKPT-----HTP-----------I---KG-----L-VVN----P-------H---------------------------------------------------------G--------------------G---------PHGC--------------------------------------------YPTSFDLQSAAL--------CKL-GFA-----V----------------------------------------SR------I-N---YR--G----ST---------------GFGQNSIFSLPGNIS-----------KQDVFD--VQQV----------------------------------------------A-----------------------------E--FVSE-------------------------------------------R---L-------NTG--------------------------------------------------------V----R-FI--T-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTL------------------------------------------QLIGQ------------------------FPD--YYSA-------------A--AAR------------------------------------------N-----PVTNIAS-----------------I------------------------------------------------------------VGVSDI-------------------RDWAFCVA-----------GC----KFTY------------------DACV---TSDMYNTM---------LTVSP----I--MH-------------------------------------------------V--DDV-KT--------------------------------------------P------------------------------------------------------------VM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IM-L-----GEADL--RVPI-SQSH-----------EYA-RM-L-----RAR-----------------GK-------T-------------VRLFQY--KD-------------N------------------------------------NHPISNV------KDEADC-----FVNILSW-------------------------------------- 895
896 --------------------------------------------------------------------P-----C-VLV----P-------H---------------------------------------------------------G--------------------G---------PHAT--------------------------------------------TTTAFSPATTAL--------VLE-GFT-----L----------------------------------------AL------P-N---YT--G----SL---------------GYGEAPIRALVGACG-----------RTDVDD--C-----------------------------------------------------------------------------------IGTL-DHLVKIGIAE----------------------------DGPG----------------------------------------------------------------------R----V-FV--Q-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSA------------------------------------------HLIGQ------------------------FPD--RFSG-------------A--VMR------------------------------------------N-----PVISVGE------------------------------------------------------------------------------ISTTDI-------------------PDWYFSEF-----------GY----EYPVLSSTAESTDSQARNGDPDSIAP-LMTGQTFTQL---------QSASP----I--HH-------------------------------------------------V--DKV-KA--------------------------------------------P------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-V-----GLADR--RVAP-THGV-----------EYY-HA-L-----TAR-----------------AR-------K-------------VELLTF--EG-------------E------------------------------------SHPLDGV------EAARVC-----WEAGRDWLR------------------------------------ 896
897 --------------------------------------------------DS-----------K---TP-----L-IVF----P-------H---------------------------------------------------------G--------------------G---------PHVN--------------------------------------------AVQDFYPSLLFW--------ALE-GFA-----V----------------------------------------LS------V-N---YR--G----SS---------------GYGQDHIESLCGKIG-----------RQDVDD--MLHA----------------------------------------------T-----------------------------E--EVLRR-YPH------------------------------------------L-------DRD--------------------------------------------------------R----V-VV--C-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSL------------------------------------------HLLAQ------------------------FPS--MFKA-------------A--AVR------------------------------------------N-----PVTNVAT-----------------M------------------------------------------------------------FGATDI-------------------PDWCYTEI-----------GM----EACF-------------------AQP---SAEQYSKA---------FSMSP----M--AH-------------------------------------------------V--SNV-SG--------------------------------------------P------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-V-----GGDDR--RVPP-FQSK-----------EYY-FA-L-----KER-----------------GA-------D-------------VEMLWY--DK-------------H------------------------------------THGLAET-----PKGEGDG-----IVNIIKFFKRK---------------------------------- 897
898 --------------------------------------------------------------------P-----L-VVM----P-------H---------------------------------------------------------G--------------------G---------PHGV--------------------------------------------ISTGYSLYLSLL--------VSF-GFA-----V----------------------------------------AQ------V-N---YS--G----ST---------------GYGDDFVQDVVGRIG-----------ELDLAD--VNAA----------------------------------------------A-----------------------------Y--WASTL-----------------------------------------PG---I-------NKK--------------------------------------------------------K----V-SL--F-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-ITA------------------------------------------HLLGF------------------------EPD--FYKA-------------G--VLR------------------------------------------N-----PVINIGA-----------------M------------------------------------------------------------VATTDI-------------------SDWCFAEA-----------GL----AF-------------------DQSKPHLVTPQEYEFM---------FRHSP----A--SV-------------------------------------------------V--HKI-KS--------------------------------------------P------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-L-----GAGDR--RVPP-SEGL-----------RWS-QY-L-----RGA-----------------GK-------D-------------ISVIMF--PS-------------V------------------------------------GHALDSF------EAERYG-----F-------------------------------------------- 898
899 ------------------------LLIPSTCSSSDYEATVMLPSSTPPTDGY----------------P-----V-ILE----L-------H---------------------------------------------------------G--------------------G---------PHGN--------------------------------------------SPVMYRHMCDFW--------AAL-GFA-----I----------------------------------------VT------V-N---YR--G----ST---------------GFGIKALESLIGKVG-----------TQDVYD--CHYA----------------------------------------------L-----------------------------C--YLLEK-SSR-----------------------------------LGLS---L-------DKS--------------------------------------------------------R----V-HC--S-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LVT------------------------------------------HLIAQ------------------------FPG--FYKS-------------M--VTR------------------------------------------N-----PVTNLSS-----------------V------------------------------------------------------------FYTSDI-------------------QDWGLACA-----------GI----QRFESIHTSQKLQNSKDKLPPLSPDA---RLAILSKL---------WQHSP----V--SN------------------------------------------------DL--SKV-TT--------------------------------------------P------------------------------------------------------------SL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FG-L-----GGKDK--RVPP-NQGL-----------EYR-AT-I-----SSY-----------------GV-------P-------------TQLLWY--PE-------------D------------------------------------SHPLGSV------EATGDF-----AVNWGLWLLK----------------------------------- 899
900 ----------------------------LERDGATYEGILIVPNEGN----------------N---LP-----M-VVN----P-------H---------------------------------------------------------G--------------------G---------PHGA--------------------------------------------SMASWPRRDLTT--------LLNSGYA-----V----------------------------------------LQ------V-N---FR--G----SL---------------GFGDDFIRALPGNCG-----------DMDVKD--VHNA----------------------------------------------V-----------------------------L--TVLDK-NPR------------------------------------------I-------SRD--------------------------------------------------------K----V-VL--F-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LVS------------------------------------------HLIGQ------------------------YPG--FYKS-------------C--VAL------------------------------------------N-----PVVNIAT-----------------M------------------------------------------------------------HDITDI-------------------PEWCYFEGT----------GE----YPDW------------------TKIT---TTEQREKM---------FNSSP----I--AH-------------------------------------------------V--ENA-TT--------------------------------------------P------------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-I-----GEKDL--RVVP--HYR-----------AFI-RA-L-----KAR-----------------GV-------P-------------ARVLTY--PP-------------S------------------------------------NHPLDEV------NVEADY-----AINMVRWFE------------------------------------ 900
901 -------------------------FVNLERDGATYEGILIVPNEGN----------------N---LP-----M-VVN----P-------H---------------------------------------------------------G--------------------G---------PHGA--------------------------------------------SMASWPRRDLTT--------LLNSGYA-----V----------------------------------------LQ------V-N---FR--G----SL---------------GFGDDFIRALPGNCG-----------DMDVKD--VHNA----------------------------------------------V-----------------------------L--TVLDK-NPR------------------------------------------I-------SRD--------------------------------------------------------K----V-VL--F-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LVS------------------------------------------HLIGQ------------------------YPG--FYKS-------------C--VAL------------------------------------------N-----PVVNIAT-----------------M------------------------------------------------------------HDITDI-------------------PEWCYFEGT----------GE----YPDW------------------TKIT---TTEQREKM---------FNSSP----I--AH-------------------------------------------------V--ENA-TT--------------------------------------------P------------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-I-----GEKDL--RVVP--HYR-----------AFI-RA-L-----KAR-----------------GV-------P-------------ARVLTY--PP-------------S------------------------------------NHPLDEV------NVEADY-----AINMVRWFEK----------------------------------- 901
902 ------------------------EILEFEHDGQTYEGILNVPNEGQ----------------N---LP-----L-VVN----P-------H---------------------------------------------------------G--------------------G---------PHGA--------------------------------------------SWAVWPRRDLTT--------LLNSGFA-----V----------------------------------------LQ------I-N---FT--G----SV---------------GFGDDFIRDLAGKCG-----------DIDAKQ--VHNA----------------------------------------------V-----------------------------L--TVLEK-NPR------------------------------------------I-------SGD--------------------------------------------------------K----C-VL--F-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MVS------------------------------------------HLIGQ------------------------YPG--FYKS-------------C--VAL------------------------------------------N-----PVVNIST-----------------M------------------------------------------------------------HDITDI-------------------PEWCFYEGT----------GE----LADW------------------TKTT---TQEQREAM---------FNASP----I--AH-------------------------------------------------V--EKA-VT--------------------------------------------P------------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-I-----GEKDL--RVVP--HCR-----------AFI-RS-L-----KAR-----------------GV-------P-------------AKVLSY--PP-------------S------------------------------------NHPLDEV------NIEADY-----AINMVR--------------------------------------- 902
903 --------------------------LEFEHDGQTYEGILNVPNEGQ----------------N---LP-----L-VVN----P-------H---------------------------------------------------------G--------------------G---------PHGA--------------------------------------------SWAVWPRRDLTT--------LLNSGFA-----V----------------------------------------LQ------I-N---FT--G----SV---------------GFGDDFIRDLAGKCG-----------DIDAKQ--VHNA----------------------------------------------V-----------------------------L--TVLEK-NPR------------------------------------------I-------SGD--------------------------------------------------------K----C-VL--F-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MVS------------------------------------------HLIGQ------------------------YPG--FYKS-------------C--VAL------------------------------------------N-----PVVNIST-----------------M------------------------------------------------------------HDITDI-------------------PEWCFYEGT----------GE----LADW------------------TKTT---TQEQREAM---------FNASP----I--AH-------------------------------------------------V--EKA-VT--------------------------------------------P------------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-I-----GEKDL--RVVP--HCR-----------AFI-RS-L-----KAR-----------------GV-------P-------------AKVLSY--PP-------------S------------------------------------NHPLDEV------NIEADY-----AINMVRWFEK----------------------------------- 903
904 -------------------------------GGYPYEALFVSPRVVES---------------L---PP-----L-IVS----S-------H---------------------------------------------------------G--------------------G---------PHMS--------------------------------------------SVADFTVWTACF--------IGL-GYS-----V----------------------------------------VF------V-N---YN--G----ST---------------GYGQDFMKSLLGNVG-----------TLDVND--VQFA----------------------------------------------A-----------------------------E--SLVK----R-------------------------------------GS---V-------DAS--------------------------------------------------------R----V-FA--H-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-LSV------------------------------------------HLVSQ------------------------FPD--FYKA-------------T--FVR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------RNETDI-------------------INWTHSVT-----------GL----SYDP------------------KVTP---TPDQYSKM---------LEISP----I--VH-------------------------------------------------A--HKI-KG--------------------------------------------A------------------------------------------------------------VT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LA-V-----GAEDH--RCHP-SQAR-----------ELY-TL-L-----HAQ-----------------GK-------D-------------VNMFLY--P--------------D------------------------------------YHPLMSV------DTDADC-----FMHCVLLFN------------------------------------ 904
905 -------------------------------GGYPYEALFVSPRVVES---------------L---PP-----L-IVS----S-------H---------------------------------------------------------G--------------------G---------PHIS--------------------------------------------SVADFTVWTACF--------IGL-GYS-----V----------------------------------------VF------V-N---YN--G----ST---------------GYGQDFMKSLLGNVG-----------TLDVND--VQFA----------------------------------------------A-----------------------------E--SLVK----R-------------------------------------GS---V-------DAS--------------------------------------------------------R----V-FA--H-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSV------------------------------------------HLVSQ------------------------FPD--FYKA-------------T--FVR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------RNETDI-------------------MDWTHSVT-----------GL----PYDP------------------KATP---TTDQYSKM---------LEMSP----I--VH-------------------------------------------------A--HKI-KA--------------------------------------------A------------------------------------------------------------VT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LA-V-----GAEDH--RCPP-SQAR-----------ELY-TL-L-----HAQ-----------------GK-------D-------------VKVFLY--PK-------------D------------------------------------CHPLMSV------DTDADC-----YMHSM---------------------------------------- 905
906 -------------------------------SGYPYEALFVSPRVVES---------------L---PP-----L-IVL----P-------H---------------------------------------------------------G--------------------G---------PHTS--------------------------------------------SIADFFVWTTCL--------VGL-GYS-----I----------------------------------------VF------V-N---YN--G----SI---------------GYGQDFIKSLLGNVG-----------TLDVND--VQFA----------------------------------------------A-----------------------------E--SLVK----R-------------------------------------GS---V-------DAS--------------------------------------------------------R----V-FA--L-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSV------------------------------------------HLVSQ------------------------FPD--FYKA-------------T--FVR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------RNETDI-------------------IDWTHSVT-----------GL----PYDP------------------KVTP---TPDQYSKM---------LEMSP----I--VH-------------------------------------------------A--HKI-KG--------------------------------------------A------------------------------------------------------------VT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LA-V-----GAEDH--RCPP-SQAR-----------ELY-TL-L-----HAQ-----------------GK-------D-------------VNMFLY--PK-------------D------------------------------------CHPLMSV------DTDADC-----YMHCVL--------------------------------------- 906
907 ---------------------------------LSYEALFVSPRVVES---------------L---PP-----L-IVL----P-------H---------------------------------------------------------G--------------------G---------PHTS--------------------------------------------SIADFFVWTTCL--------VGL-GYS-----I----------------------------------------VF------V-N---YN--G----SI---------------GYGQDFIKSLLGNVG-----------TLDVND--VQFA----------------------------------------------A-----------------------------E--SLVK----R-------------------------------------GS---V-------DAS--------------------------------------------------------R----V-FA--L-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSV------------------------------------------HLVSQ------------------------FPD--FYKA-------------T--FVR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------RNETDI-------------------IDWTHSVT-----------GL----PYDP------------------KVTP---TPDQYSKM---------LEMSP----I--VH-------------------------------------------------A--HKI-KG--------------------------------------------A------------------------------------------------------------VT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LA-V-----GAEDH--RCPP-SQAR-----------ELY-TL-L-----HAQ-----------------GK-------D-------------VNMFLY--PK-------------D------------------------------------CHPLMSV------DTDADC-----YMHCVL--------------------------------------- 907
908 -----------------------------------------------------------------------------VL----P-------H---------------------------------------------------------G--------------------G---------PHTS--------------------------------------------SIADFFVWTTCL--------VGL-GYS-----I----------------------------------------VF------V-N---YN--G----SI---------------GYGQDFIKSLLGNVG-----------TLDVND--VQFA----------------------------------------------A-----------------------------E--SLVK----R-------------------------------------GS---V-------DAS--------------------------------------------------------R----V-FA--L-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSV------------------------------------------HLVSQ------------------------FPD--FYKA-------------T--FVR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------RNETDI-------------------IDWTHSVT-----------GL----PYDP------------------KVTP---TPDQYSKM---------LEMSP----I--VH-------------------------------------------------A--HKI-KG--------------------------------------------A------------------------------------------------------------VT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LA-V-----GAEDH--RCPP-SQAR-----------ELY-TL-L-----HAQ-----------------GK-------D-------------VNMFLY--PK-------------D------------------------------------CHPLMSV------DTDA---------------------------------------------------- 908
909 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L------T-T---LN--G----RF---------------YHLQE--------------------------K--TQFA----------------------------------------------A-----------------------------E--SLVK----R-------------------------------------GS---V-------DAS--------------------------------------------------------R----V-FA--H-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-LSV------------------------------------------HLVSQ------------------------FPD--FYKA-------------T--FVR------------------------------------------N-----PVINIAS-----------------M------------------------------------------------------------RNETDI-------------------INWTHSVT-----------GL----SYDP------------------KVTP---TPDQYSKM---------LEISP----I--VH-------------------------------------------------A--HKI-KG--------------------------------------------A------------------------------------------------------------VT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LA-V-----GAEDH--RCHP-SQAR-----------ELY-TL-L-----HAQ-----------------GK-------D-------------VNMFLY--P--------------D------------------------------------YHPLMSV------DTDADC-----FMHCVLLFN------------------------------------ 909
910 --------------------------------------------------------------------P-----L-IVW----P-------H---------------------------------------------------------G--------------------G---------PHSV--------------------------------------------ICNNYNHYAQVF--------CQL-GYI-----V----------------------------------------LL------V-N---YS--G----ST---------------SFSEKSLMSLPGNIG-----------SQDIYD--VHNI----------------------------------------------A-----------------------------L--NFISA-NQSI-----------------------------------------V-------DKE--------------------------------------------------------N----V-YV--F-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-IGA------------------------------------------HLIAQ------------------------YPD--FYCA-------------A--ALR------------------------------------------N-----PVIEIAS-----------------M------------------------------------------------------------SVTSDI-------------------PDWTYAVS-----------GL----SYNF------------------SNVP---NPEVYKVM---------LEKSP----V--IL-------------------------------------------------A--DKI-KA--------------------------------------------P------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LC-V-----GSKDA--RVPP-TQSI-----------HFF-KL-L-----KSL-----------------NK-------D-------------VKMLMY--PD-------------D------------------------------------CHPLSNI------ETEGDV-----FLNVSLWFYQH---------------------------------- 910
911 -----------------------------------FEMIYLKNTSKG----------------K---KP-----T-IIF----I-------H---------------------------------------------------------G--------------------G---------FQMS--------------------------------------------VDLEYSFSFAYL--------VSL-GYN-----I----------------------------------------II------P-N---YR--G----ST---------------GFGRDFLNSLVGQIS-----------QMDVDD--CIQA----------------------------------------------L-----------------------------S--YSCEK-VDP-------------------------------------EG---I-------DPD--------------------------------------------------------K----L-CA--I-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-IGA------------------------------------------IL-AA------------------------LPGFANIKT-------------V--ILR------------------------------------------N-----PVIDQAA-----------------Q------------------------------------------------------------AMVTDI-------------------PDWSMFKC-----------GI----SIDE-------------NKKSYNTAP---TIKEIEIM---------KNLSP----I--KY-------------------------------------------------I--QDI-NI--------------------------------------------P------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-L-----GENDL--RVPPKTQGL-----------LLY-NS-L-----KER-----------------DQ-------I-------------VKCLMY--PS-------------N------------------------------------GHALE-S-----IEAKLDQ-----WINISNWLNKYL--------------------------------- 911
912 -----------------------------------FELIYVKNNKNNNSNEDNNNNNNNNSIIK---RP-----T-ILF----I-------H---------------------------------------------------------G--------------------G---------PHMN--------------------------------------------ITIEYTYPFGYL--------QSL-GYN-----I----------------------------------------II------P-N---YR--G----SS---------------GCGKDFIDCLPGKIG-----------TLDKED--CLSS----------------------------------------------L-----------------------------N--YSIEF-IDK-------------------------------------QG---I-------DIN--------------------------------------------------------R----I-SI--I-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LAT------------------------------------------YL-SI------------------------EP---LIKT-------------V--ILR------------------------------------------N-----PVIDNSF-----------------L------------------------------------------------------------ATLTDI-------------------QDWCLFKC-----------G------IDK-------------N-NLYNSLP---TLKELEIM---------RNCSP----S--TC-------------------------------------------------F--DQI-KI--------------------------------------------P------------------------------------------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-L-----GEKDK--RVYSKSQGL-----------LLY-NN-L-----IER-----------------NI-------K-------------TKCLMY--LN-------------E------------------------------------SHSLDNT-----IDSKLDQ-----WINIAKWLNE----------------------------------- 912
913 --------------------------------IKSFELIYLKNKNSTQ---------------S---SPLG---C-LVF----I-------H---------------------------------------------------------G--------------------G---------PHSN--------------------------------------------LDVGYVSTITYL--------LSL-GYN-----I----------------------------------------II------P-N---YR--G----ST---------------GYGKDFVDCLPGYIG-----------DLDVDD--CVQA----------------------------------------------I-----------------------------N--YTLDK-ID--------------------------------------NT---I-------DRN--------------------------------------------------------K----I-GV--I-G--GS-----------------HG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSA------------------------------------------HL-SR------------------------FP---IVKT-------------S--IMR------------------------------------------N-----PVIDIPS-----------------M------------------------------------------------------------STLSDI-------------------PDWCFFEA-----------GI----NLSD-------------PTSQYHTLP---SMEEIEKM---------RKCSP----S--FH-------------------------------------------------I--ENI-KI--------------------------------------------P------------------------------------------------------------SL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LA-L-----GDSDL--RVPP-SQGL-----------LYY-RM-L-----RER-----------------DV-------P-------------TKCLMY--PK-------------T------------------------------------GHSLD-S-----IDARLDQ-----WVNISLWLKK----------------------------------- 913
914 VGEVE---------------------YVKVKTDVEVPTWVI---KR-----------------K---IPGN---T-IIY----I-------H---------------------------------------------------------G--------------------G---------PWSE--------------------------------------------VDNSWNLLIAPL--------VLA-GYN-----V----------------------------------------IA------P-N---YR--G----ST---------------GYGSKFMFMNIGDAG-----------GGDLRD--VVKV----------------------------------------------R-----------------------------D--YAIET-GIT----------------------------------------------------N--------------------------------------------------------K----V-GI--M-G--YS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTL------------------------------------------LAVGK--------------------------EPDKWDF-------------G--IAG------------------------------------------A-----AVADWVE-----------------M------------------------------------------------------------YDLSDSLFRGFMEILF---------------------------------------------------------------NGKNIDLM---------KERSP----I--TY-------------------------------------------------V--RNV-KV--------------------------------------------P------------------------------------------------------------LC--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-H-----SQNDT--RTPL-NPVM-----------RYI-QE-L-----QRT-----------------GK-------T-------------YEFHVI--PN-------------L------------------------------------GHAIYKVSDAIDILLPALIFLKK---------------------------------------------- 914
915 LPSGEPLLEGGLPEDLRRSIAGSRLVWVESFDGSRVPTYVLESGRA-----------------P---TPGP---T-VVL----V-------H---------------------------------------------------------G--------------------G---------PFAE--------------------------------------------DSDSWDTFAASL--------AAA-GFH-----V----------------------------------------VM------P-N---YR--G----ST---------------GYGEEWRLKIIGDPC-----------GGELED--VSAA----------------------------------------------A-----------------------------R--WARES-GLA----------------------------------------------------S--------------------------------------------------------E----L-YI--M-G--YS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTL------------------------------------------CALTM--------------------------KPGLFKA-------------G--VAG------------------------------------------A-----SVVDWEE-----------------M------------------------------------------------------------YELSDAAFRNFIEQLT---------------------------------------------------------------GGSR-EIM---------RSRSP----I--NH-------------------------------------------------V--DRI-KE--------------------------------------------P------------------------------------------------------------LA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----PQNDS--RTPL-KPLL-----------RLM-GE-L-----LAR-----------------GK-------T-------------FEAHII--PD-------------A------------------------------------GHAINTMEDAVKILLPAVFF------------------------------------------------- 915
916 YDS----------------------------NGLRIYALLYEKGGE-----------------D------K---G-IVY----I-------H---------------------------------------------------------G--------------------G---------PDWE--------------------------------------------CVNSFNPEIQFF--------MER-GFK-----V----------------------------------------IC------P-N---YR--G----SI---------------GYGRRFNHLNDKDPG-----------GGELLD--VIN---------------------------------------------------------------------------------SVKV-LGV----------------------------------------------------K--------------------------------------------------------K----I-AI--T-G--AS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LTM------------------------------------------MATTK--------------------------FSDLWCS-------------A--VAV------------------------------------------V-----PFVNWFT-----------------E------------------------------------------------------------KKLEREILQLYDEIKV---------------------------------------------------------------GNDE-NLL---------RDRSP----I--FF-------------------------------------------------I--DRI-KT--------------------------------------------S------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-A-----GENDP--RCPA-EETL-----------QVV-EE-L-----RKL-----------------GR-------E-------------VKYKIY--KD-------------E------------------------------------GHGFAKIENYVDSIKEAVEFITSHC-------------------------------------------- 916
917 ------------------------------PDSDRPYANLG----MIPAVPQK---------------------M-IVL----V-------H---------------------------------------------------------G--------------------G---------PKAR--------------------------------------------DHYGFSPMNAWL--------TNR-GYA-----V----------------------------------------LQ------V-N---FR--G----ST---------------GFGKRLTNAGNGEWG-------R----KMHFD--ILDA----------------------------------------------V-----------------------------E--FAVSK-----------------------------------------GI---A-------NRT--------------------------------------------------------E----V-AV--M-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-ETL------------------------------------------VALTF------------------------TPQ--TFAC-------------G--VDI------------------------------------------V-----GPSNLIS-----------------L------------------------------------------------------------VQAIP--------------------PYW----------------------------------LGF-RKDLIKMVGADIVTEEGRQSL---------QSRSP----L--FF-------------------------------------------------A--DRV-SR--------------------------------------------P------------------------------------------------------------IM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-Q-----GANDP--RVKQ-AESD-----------QFV-LA-L-----EKK-----------------NI-------P-------------VTYLLY--PD-------------E------------------------------------GHGVRKP-----QNSMEQHGHIETFLQQ----------------------------------------- 917
918 ------------------------------PDGDRPYANLG----MIPAVPQK---------------------M-IVL----V-------H---------------------------------------------------------G--------------------G---------PKAR--------------------------------------------DHYGFSPMNAWL--------TNR-GYS-----V----------------------------------------LQ------V-N---FR--G----ST---------------GFGKRLTNAGNGEWG-------R----KMHFD--ILDA----------------------------------------------V-----------------------------E--FAVSK-----------------------------------------GI---A-------NRS--------------------------------------------------------E----V-AV--M-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-ETL------------------------------------------VALTF------------------------TPQ--TFAC-------------G--VDI------------------------------------------V-----GPSNLIS-----------------L------------------------------------------------------------VQAIP--------------------PYW----------------------------------LGF-RKDLIKMVGADISDEEGRQSL---------QSRSP----L--FF-------------------------------------------------A--DRV-TK--------------------------------------------P------------------------------------------------------------IM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-Q-----GANDP--RVKQ-AESD-----------QFV-AA-L-----EKK-----------------HI-------P-------------VTYLLY--PD-------------E------------------------------------GHGVRKP-----QNSMEQHGHIETFLQQ----------------------------------------- 918
919 --------------LETLQLASMEPISYEARDGLTIHSYLT----TPVGIPTQ----------N---LP-----T-VLL----V-------H---------------------------------------------------------G--------------------G---------PWAR--------------------------------------------DVWGFSPTAQWL--------ANR-GYA-----V----------------------------------------LQ------V-N---FR--G----ST---------------GYGKAFLNAGNREWA-------G----KMHDD--LIDS----------------------------------------------V-----------------------------N--WLVEQ-----------------------------------------GI---S-------DPQ--------------------------------------------------------K----I-AI--M-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-ATL------------------------------------------VGLTF------------------------TPE--LFAA-------------G--VDI------------------------------------------V-----GPSNLIT-----------------L------------------------------------------------------------IGTIP--------------------PYW----------------------------------EPL-KAMLYHRVG-NLETEE--EFL---------KSRSP----L--FF-------------------------------------------------A--DRI-QK--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IG-Q-----GANDP--RVKQ-AESD-----------QIV-NA-M-----QEA-----------------GL-------P-------------VQYALY--TD-------------E------------------------------------GHGFARP-----ENRLHFFAIAEEFLAKYL--------------------------------------- 919
920 -------------------LVKGEVIRYPSYDGLMIPALYYKPK-IIES--GQ----------K---IP-----A-LIW----V-------H---------------------------------------------------------G--------------------G---------PGGQ--------------------------------------------SCVGYSSLIQYL--------VNH-GYA-----V----------------------------------------IA------V-N---NR--G----SS---------------GYGKTFYEAADRKHG-------E----ADLDD--CIWA----------------------------------------------K-----------------------------K--FLIST-----------------------------------------GY---V-------DAD--------------------------------------------------------K----I-GM--I-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTL------------------------------------------AALAF------------------------RPS--EMAV-------------G--VDL------------------------------------------F-----GLSNWIS-----------------T------------------------------------------------------------LKKIP--------------------AWW----------------------------------EYQ-RESLYQKIG-DPEKDT--AYL---------ESISP----L--FH-------------------------------------------------A--KNI-TK--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI-Q-----GANDP--RVLQ-AESD-----------QIV-EA-V-----NKN-----------------GT-------P-------------YRYEIY--QD-------------E------------------------------------GHGFTKK-----QNKI----------------------------------------------------- 920
921 QRGVADTAFAMRPDIDRAQLAPTTFHWFRARDGLRLSLLLTRSRVRVPGSANA----------R---QP-----A-VVA----V-------H---------------------------------------------------------G--------------------G---------PWSR--------------------------------------------DEVGYAGETQLL--------ANR-GYT-----V----------------------------------------IQ------V-N---FR--G----ST---------------GLGRATVDGAVGEFG-------Q----RMSDD--LLDA----------------------------------------------I-----------------------------A--WSVRN-----------------------------------------AN---V-------DPA--------------------------------------------------------R----V-CI--L-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-AAL------------------------------------------VGMTR------------------------DAA--HYRC-------------G--IDY------------------------------------------A-----GPFDLET-----------------L------------------------------------------------------------IRAFP--------------------PSW----------------------------------QPFLPRSWYRFVG-NPDQPAALERM---------RRVSP----L--AQ-------------------------------------------------L--EKA-RG--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-H-----GDNDP--RVRT-DQAL-----------RVV-RS-W-----RAR-----------------SL-------P-------------VSLLLA--GN-------------E------------------------------------GHSFNEE-----STSLAVNRAVERFL------------------------------------------- 921
922 -------------------------ITYASFDGLKIEALLFRAKGEVQN--GY----------T---I---------FW----P-------H---------------------------------------------------------G--------------------G---------PQSA--------------------------------------------ETKNFRALFQYL--------LRQ-GYN-----I----------------------------------------FA------P-N---FR--G----ST---------------RYGSTFTKMIEGDWG-------E----APRLD--CVAG----------------------------------------------I-----------------------------E--WLFEQ-----------------------------------------GI---S-------TPD--------------------------------------------------------K----L-FV--M-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTL------------------------------------------LLYGR------------------------HSE--YFRA-------------A--IDI------------------------------------------F-----GPSNLFS-----------------F------------------------------------------------------------IESMP--------------------ENW----------------------------------KPL-AVNL---IG-DIKNDE--DKL---------INDSP----I--TY-------------------------------------------------L--NQM-NK--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-Q-----GANDP--RVVK-TESD-----------QIF-RA-L-----QEK-----------------EV-------D-------------VEYLVL--DD-------------E------------------------------------GHGFSKK-----ENE------------------------------------------------------ 922
923 -------------------------ITYASFDGLNIEALLFRAKGEVQN--GY----------T---I---------FW----P-------H---------------------------------------------------------G--------------------G---------PQSA--------------------------------------------ETKDFRALFQYL--------LRQ-GYN-----I----------------------------------------FA------P-N---FR--G----ST---------------RYGSTFTKMIEGDWG-------E----APRLD--CVAG----------------------------------------------I-----------------------------E--WLFEQ-----------------------------------------GI---S-------TPD--------------------------------------------------------K----L-FV--M-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTL------------------------------------------LLYGR------------------------HSE--YFRA-------------A--IDI------------------------------------------F-----GPSNLFS-----------------F------------------------------------------------------------IESMP--------------------ENW----------------------------------KPL-AVNL---IG-DIKNDK--DKL---------IKDSP----I--TY-------------------------------------------------L--NQM-NK--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-Q-----GANDP--RVVK-TESD-----------QIF-RA-L-----QEK-----------------EV-------D-------------VEYIVL--ED-------------E------------------------------------GHGFSKK-----ENE------------------------------------------------------ 923
924 DTEWAALTKNYVIGLSESSFVEPNVITYASFDGLNIEALLFRAKGEVQN--GY----------T---I---------FW----P-------H---------------------------------------------------------G--------------------G---------PQSA--------------------------------------------ETKGFRELFQYL--------LRQ-GYN-----I----------------------------------------FA------P-N---FR--G----ST---------------RYGSTFTKMIEGDWG-------E----APRLD--CVAG----------------------------------------------I-----------------------------E--WLFEQ-----------------------------------------GI---S-------TPD--------------------------------------------------------K----L-FV--M-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTL------------------------------------------LLHGR------------------------HSE--YFRA-------------A--IDI------------------------------------------F-----GPSNLFS-----------------F------------------------------------------------------------IESMP--------------------ENW----------------------------------KPL-AVNL---IG-DINNDK--DKL---------IQDSP----I--TY-------------------------------------------------L--NQM-NK--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-Q-----GANDP--RVVK-EESD-----------QIF-HA-L-----QEQ-----------------GV-------D-------------VEYLVL--DD-------------E------------------------------------GHGFSKK-----ENEIYVYRRITEFLAK----------------------------------------- 924
925 -------------------------ITYSSFDGLNIEALLFRAKEEVQN--GY----------T---I---------LW----P-------H---------------------------------------------------------G--------------------G---------PQWA--------------------------------------------EIKDFTALFQYL--------LRQ-GYN-----I----------------------------------------FA------P-N---FR--G----ST---------------RYGSTFTKMIEGDWG-------E----APRLD--CVAG----------------------------------------------I-----------------------------K--WLFEQ-----------------------------------------GI---S-------TAD--------------------------------------------------------K----L-FV--M-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTL------------------------------------------LLYGR------------------------HSE--YLRA-------------A--IDL------------------------------------------F-----GPSSLFS-----------------F------------------------------------------------------------IDSMP--------------------EEW----------------------------------KPI-AVSF---IG-DVEKDK--DKL---------MKDSP----I--TY-------------------------------------------------L--NQM-KK--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-Q-----GANDP--RVVK-TESD-----------QIF-QA-L-----QEK-----------------EV-------D-------------VEYIVL--ED-------------E------------------------------------GHGFSKK-----ENE------------------------------------------------------ 925
926 LRRILDDSGITAGSPPETALARKLAIAYTTSDGTRVHGFVLLP----PGVDAA----------R---AP-----L-IAH----V-------H---------------------------------------------------------G--------------------G---------PANH--------------------------------------------FRAGYDGTAQFL--------ANR-GYV-----V----------------------------------------FQ------S-N---FR--G----ST---------------GHGLGYTFAPNGDYG-------N---GRVQQD--IVEG----------------------------------------------V-----------------------------R--WLLAQ-----------------------------------------GI---G-------DKD--------------------------------------------------------W----V-GI--V-G--HS-----------------FG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-STL------------------------------------------LGLTF------------------------QSE--LFKV-------------G--VAG------------------------------------------S-----PPADL----------------------------------------------------------------------------------GWA--------------------MRW----------------------LLEAGDQGDLPDRSL--KHTLAALSLDGTDAATFARL---------HAQSP----L--VN-------------------------------------------------A--AKM-HR--------------------------------------------P------------------------------------------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IM-A-----GGADR--TVAI-REVL-----------NYA-AT-V-----KAA-----------------GR-------P-------------LSLLVE--PG-------------G------------------------------------GH------------------------------------------------------------------- 926
927 --------------------------------------------------------------------------PAMLW----F-------H---------------------------------------------------------G--------------------G----S-----------------------------------------------------------------------------WAS-GT------WWHSPGVMG--ALRENGVTVVGVEL-RT------------------S---NR-FD-------------SGPL-------------------------------EQVED--AMLA----------------------------------------------H-----------------------------E--WIVRH-------------------------------------------------------ASR----------------LRID---------------------------------STR----V-GV--A-G--FS-----------------SG-----------------------------A-TLATI---LGTRGLL---------PLPPLPVGDNPPTPTPATVRRYPAAVIAVGAC---VLPGGPAEDGFFRKV-VGAQAVVS---------------------------------------------------------------------------------------------------------------E-FTP------------------------------------------------LM-------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIMAG----------------------------------------------------------QP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------TL------------------------------------------------------FVHAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NDE--Y----------------C--------------DMKSV--------------------RSFVE------------------QSVSYGNR--VALS----------------------------------EVE--N-AGHF---------FGF-YHPAGQRQMR------------------------------------------- 927
928 -----------------------------------------GNGPGVLV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LHAWWGLNDTIKMYCTQLAGAGFV---AFAPDLY-----HGKVTDNIAEAEA-----------LAQALDANHRQVRAEIVQATRFLSEHADKATRGL----AV--I-G--FS-----------------LG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-YALDLS-----------------------ATCPEYIRS-----------------------------VVLFYGTGLADFSNSKAAYLG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-----AANDP--FEPQANIYSLEDALKQAGRPVTFYHY-----------------------------------------------------------------------------------------------------------SGTGHWFCEPDRDQAYNPAAARLAWER--------------------------------------------- 928
929 -------------------------------DGALVHSFFFRPHNNFDTSRD-----------K---CP-----L-ILY----V-------H---------------------------------------------------------G--------------------G---------PESP------WDDSWS------------------------------------YRWNPQIL--------VEQ-GYC-----V----------------------------------------LA------T-N---FH--G----SG---------------SFGEEFQKSIRQHWF-----------DIPVDD--TMSA----------------------------------------------W-----------------------------K--YVHET-YSY------------------------------------------V-------DKE--------------------------------------------------------K----T-CA--M-G--AS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-HVN------------------------------------------WLMG-------------------------H--TDNITC-------------F--IVH------------------------------------------D-----GIFDLTS-----------------F------------------------------------------------------------GLDTD-ELFFVIREMG---G-----PVW-EQFE-------------------------------------------------MYERW------------NP----A--RS-------------------------------------------------A--KNF-SK--------------------------------------------P------------------------------------------------------------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI-H-----GGKDF--RIHE-YHGI-----------ALF-QS-L-----QLR-----------------GV-------P-------------SRFIYF--PT-------------Q------------------------------------SHWVWQ--------PQESVVW---HTEVVAWLDKY---------------------------------- 929
930 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K----T-CA--M-G--AS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-HVN------------------------------------------WLMG-------------------------H--TDNITC-------------F--IVH------------------------------------------D-----GIFDLTS-----------------F------------------------------------------------------------GLDTD-ELFFVIREMG---G-----PVW-EQFE-------------------------------------------------MYERW------------NP----A--RS-------------------------------------------------A--KNF-SK--------------------------------------------P------------------------------------------------------------AL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI-H-----GGKDF--RIHE-YHGI-----------ALF-QS-L-----QLR-----------------GI-------P-------------SRFIYF--PT-------------Q------------------------------------SHWVWQ--------PQESVVW---HTEVVTWLDKY---------------------------------- 930
931 -------------------YPPEEFYLESGIDGAMVHSFFFRPHNGFDTSKD-----------K---CP-----L-ILY----I-------H---------------------------------------------------------G--------------------G---------PESP------WDDAWS------------------------------------YRWNPQIL--------VEQ-GYC-----V----------------------------------------LA------T-N---FH--G----SG---------------SFGEAFQKSIRQHWF-----------DLPVDD--TMSA----------------------------------------------W-----------------------------K--YVHET-YSF------------------------------------------I-------DKE--------------------------------------------------------K----T-CA--M-G--AS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-HVN------------------------------------------WLMG-------------------------H--TDNITC-------------F--IVH------------------------------------------D-----GIFDLTS-----------------F------------------------------------------------------------GLDTD-ELFFVIREMG---G-----PVW-EQFD-------------------------------------------------MYEQW------------NP----A--RS-------------------------------------------------A--KNF-SK--------------------------------------------P------------------------------------------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI-H-----GGQDF--RIHE-YHGI-----------ALF-QS-L-----QLR-----------------GV-------P-------------SRLIYF--PT-------------Q------------------------------------SHWVWQ--------PQESVVW---HTEVVAW-------------------------------------- 931
932 ----------------------------------YVHSWYFAPANLRDSH-------------E---YP-----L-ILY----V-------H---------------------------------------------------------G--------------------G---------PESP------WANSWS------------------------------------YRWNPQLI--------AAR-GYG-----V----------------------------------------LA------T-N---FH--G----SS---------------SFGEVFQKSVRGNWY-----------SYPLED--IMDA----------------------------------------------W-----------------------------SNIYTHAD-KAY------------------------------------------L-------SRE--------------------------------------------------------K----V-CA--M-G--AS-----------------FG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-FMN------------------------------------------YMNS-------------------------H--VNNVTC-------------Y--VTH------------------------------------------D-----GVFDTMC-----------------N------------------------------------------------------------ALETD-ELFFPVRELG---G-----FLLDEQVD----------------------------------------------NQQLYEKW------------NP----A--RF-------------------------------------------------V--ENM-SA--------------------------------------------P------------------------------------------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI-H-----GQKDY--RIQV-YHGI-----------SLF-QA-L-----RLR-----------------GI-------K-------------TKLVYF--PT-------------Q------------------------------------SHWVWQ--------PQESLFW---HTQVFDW-------------------------------------- 932
933 ---------------------------------QYVHSWYFAPVNLRDGH-------------K---HP-----L-VLY----V-------H---------------------------------------------------------G--------------------G---------PESP------WANSWS------------------------------------YRWNPQII--------AAR-GYG-----V----------------------------------------LA------T-N---FH--G----SS---------------SFGEAFQKSVRGNWY-----------SYPLED--VMDA----------------------------------------------W-----------------------------SNIYTHAD-KVY------------------------------------------L-------SRE--------------------------------------------------------K----V-CA--M-G--AS-----------------FG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-FMN------------------------------------------YMNS-------------------------H--VNNVTC-------------Y--VTH------------------------------------------D-----GVFDTMC-----------------N------------------------------------------------------------ALETD-ELFFPVRELG---G-----FLLDEQVD----------------------------------------------NQQLYEKW------------NP----A--RF-------------------------------------------------V--ENM-SA--------------------------------------------P------------------------------------------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI-H-----GQKDY--RIQV-YHGI-----------SLF-QA-L-----RLR-----------------GI-------E-------------TKLVYF--PT-------------Q------------------------------------SHWVWQ--------PQESLFW---HAQVFDWL------------------------------------- 933
934 -----------------------------------VHSWYFAPAGLTDGR-------------E---YP-----L-ILY----V-------H---------------------------------------------------------G--------------------G---------PESP------WANSWS------------------------------------YRWNPQLI--------AAR-GYG-----V----------------------------------------LA------T-N---FH--G----SS---------------SFGEAFQKSVRGNWY-----------SYPLED--VMDA----------------------------------------------W-----------------------------SNIYTRPD-KVY------------------------------------------L-------SRE--------------------------------------------------------K----V-CA--M-G--AS-----------------FG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-FMN------------------------------------------YMNS-------------------------H--ISNVTC-------------Y--VTH------------------------------------------D-----GVFDTMC-----------------N------------------------------------------------------------ALETD-ELFFPVRELG---G-----FLLDEKVD----------------------------------------------NRPLYEKW------------NP----A--RF-------------------------------------------------V--ENM-SA--------------------------------------------P------------------------------------------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI-H-----GQKDY--RIQV-YHGI-----------ALF-QA-L-----RLR-----------------GI-------E-------------TKLVYF--PT-------------Q------------------------------------SHWVWQ--------PQESLFW---HAQVFDW-------------------------------------- 934
935 -------------------FGEYKEIHYTGANNDQIHAFITYPPNMKTNT-------------K---YP-----V-ILY----T-------H---------------------------------------------------------G--------------------G---------PESP------WTNNFH------------------------------------YRWNPQVI--------AAQ-GYI-----V----------------------------------------FA------P-N---FH--G----SG---------------SYGDAFLKAIRKNWG-----------GWPFED--LMKG----------------------------------------------M-----------------------------D--YLKTS-EPL------------------------------------------V-------DID--------------------------------------------------------N----A-CA--M-G--AS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MMN------------------------------------------WINSQ------------------------N--TGRFKC-------------I--ICH------------------------------------------D-----GIMDSEG-----------------S------------------------------------------------------------YYYMD-EMYFLETEFG---Y-----PMY----E----------------------------------------------DDTYYKKY------------SP----L--NY-------------------------------------------------V--NGY-NT--------------------------------------------P------------------------------------------------------------QL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TI-H-----GGSDY--RIDV-VAGY-----------QQF-VT-L-----QRK-----------------NI-------E-------------SKLVIY--PE-------------E------------------------------------NHWVLR--------PYNSIDW---HAQVFDWLAKY---------------------------------- 935
936 -----------------------------------VQGWAIKPKGWEANAAK-----------K---WP-----V-VLL----I-------H---------------------------------------------------------G--------------------G---------MYFG------LSDSASCSIGVFQGPKALGRTNGPRGGIQMVRVECLISANKPSKSHPLVF--------ANQ-GYF-----V----------------------------------------IM------I-N---PT--G----ST---------------TFGQEFTDAIAEDWG-----------GKPFID--MING----------------------------------------------W-----------------------------K--YVLEK-YPE------------------------------------------I-------DAE--------------------------------------------------------R----A-VA--A-G--AS-----------------WG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-AIN------------------------------------------WIQGH------------------------PEFGFGFKA-------------L--VAH------------------------------------------D-----GVFDATY-----------------N------------------------------------------------------------GYSTD-ELFFVIQPRM---GREASLRPW--ESK----------------------------------------------SKRLSEKM------------SP----S--NY-------------------------------------------------V--HKW-ST--------------------------------------------P------------------------------------------------------------QL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GSKDY--RLPE-TESI-----------GAF-HA-L-----QQL-----------------GI-------P-------------SRLVIF--PD-------------E------------------------------------NHWVLN--------HGN---------------------------------------------------- 936
937 -----------------------------------VMGWALKPRGWKPDQKA-----------K---YP-----L-AFL----I-------H---------------------------------------------------------G--------------------G---------PQSA------WDDSWS------------------------------------TRWNPALF--------AAQ-GYF-----V----------------------------------------VA------I-N---PT--G----ST---------------GYGQEFTDAIQGDWG-----------GKPFKD--LLAG----------------------------------------------Y-----------------------------H--YVLEN-YPE------------------------------------------I-------DPE--------------------------------------------------------R----T-AG--L-G--AS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MVN------------------------------------------WINGH------------------------N-DHFGFKA-------------L--VCH------------------------------------------D-----GVFDTVT-----------------T------------------------------------------------------------FFSTE-EIYFPTQDFA---G-----TPW--TNR----------------------------------------------AT--YEKW------------NP----V--NH-------------------------------------------------V--IEW-NT--------------------------------------------P------------------------------------------------------------EL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI-Q-----GGKDY--RLEN-SQGL-----------GAF-TA-L-----QLQ-----------------GV-------P-------------SRFVYF--PD-------------E------------------------------------NHWILK--------PHNSIKW---HHEVFRWL------------------------------------- 937
938 ------------------------------------HAWVIYPEGF--DKSK-----------T---YP-----L-AFL----I-------H---------------------------------------------------------G--------------------G---------PQGA------WYNSWS------------------------------------SRWNPKVF--------ADQ-GYV-----V----------------------------------------VA------P-N---PT--G----ST---------------GYGDELTDAIQNNWG-----------GAPYED--LVKA----------------------------------------------W-----------------------------E--YVRDN-LDY------------------------------------------V-------DTD--------------------------------------------------------R----G-VA--A-G--AS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MVN------------------------------------------WIQGS------------------------D-LGREFKA-------------L--VTH------------------------------------------D-----GTF-VAD-----------------A------------------------------------------------------------KISTE-ELWFMEREFN---G-----TFW--DVR----------------------------------------------DN--YRRF------------DP----SAPER-------------------------------------------------I--LRF-AT--------------------------------------------P------------------------------------------------------------HL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-H-----NDLDY--RLPV-AEGL-----------SLF-NV-L-----QER-----------------GV-------P-------------SRFLNF--PD-------------E------------------------------------NHWVTS--------PENSLVW---HQQVLGWLNKYSG-------------------------------- 938
939 ----------------------------------DIHAWVIYPENF--DKSK-----------K---YP-----L-IFF----I-------H---------------------------------------------------------G--------------------G---------PQGN------WADGWS------------------------------------TRWNPKAW--------ADQ-GYV-----V----------------------------------------VA------P-N---PT--G----ST---------------GFGQALTDAIQNNWG-----------GAPYDD--LVKC----------------------------------------------W-----------------------------E--YVHEN-LDY------------------------------------------V-------DTD--------------------------------------------------------H----G-VA--A-G--AS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MIN------------------------------------------WIQGS------------------------P-LGRKFKA-------------L--VSH------------------------------------------D-----GTF-VAD-----------------A------------------------------------------------------------KVSTE-ELWFMQREFN---G-----TFW--DAR----------------------------------------------DN--YRRW------------DP----SAPER-------------------------------------------------I--LQF-AT--------------------------------------------P------------------------------------------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI-H-----SDKDY--RLPV-AEGL-----------SLF-NV-L-----QER-----------------GV-------P-------------SRFLNF--PD-------------E------------------------------------NHWVVN--------PENSLVW---HQQALGW-------------------------------------- 939
940 ----------------------------------PIHAWVVKPSNF--RPGS-----------K---YP-----L-AFL----V-------H---------------------------------------------------------G--------------------G---------PQGA------WNDQWS------------------------------------TRWNPAVF--------AEQ-GYV-----V----------------------------------------IT------P-N---PR--G----ST---------------GYGQEFTDAIRGSWG-----------GLPYID--LEKG----------------------------------------------F-----------------------------D--YIEKN-LKY------------------------------------------V-------DTN--------------------------------------------------------R----A-VA--L-G--AS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MMN------------------------------------------WIQGQ------------------------P-LGRRFRA-------------L--VTH------------------------------------------D-----GVF-STT-----------------S------------------------------------------------------------LLATE-ELYFPLHDLK---G-----VQW--IVP----------------------------------------------EN--WAQW------------DP----S--RH-------------------------------------------------L--DKW-QT--------------------------------------------P------------------------------------------------------------HL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-H-----NEKDY--RLTI-AEGL-----------SAF-NV-L-----QMK-----------------GI-------D-------------SAFLTF--PD-------------E------------------------------------NHWVLN--------PENALMW---HYTIFNW-------------------------------------- 940
941 --------------------------------GDKVQSILVKPPFF--DPAK-----------K---YP-----M-VFL----I-------H---------------------------------------------------------G--------------------G---------PQGA------WEDNFH------------------------------------FRWNYQMF--------ASQ-GYV-----V----------------------------------------VA------P-N---PR--G----ST---------------GYGQKFTDEISGDWG-----------GKVYTD--LMNS----------------------------------------------Y-----------------------------D--YAVKN-FSF------------------------------------------I-------DSK--------------------------------------------------------N----T-FA--A-G--AS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MIN------------------------------------------WIAGH------------------------T---DRFNA-------------L--VSH------------------------------------------A-----GVFNLES-----------------M------------------------------------------------------------YGTTE-ELWFPEWEYG---G-----TPW--QKR----------------------------------------------EV--YEKW------------SP----H--RY-------------------------------------------------I--HNC-KT--------------------------------------------P------------------------------------------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-H-----GAKDF--RVPE-EQAF-----------QLF-TS-L-----QRL-----------------GI-------E-------------SKFLYF--PD-------------E------------------------------------THFVAK--------PLNSKLW---WET------------------------------------------ 941
942 --------------------GKVEGRWMKTTDGKDMLTWVIYPPQF--DPNK-----------K---YP-----T-LLF----C-------E---------------------------------------------------------G--------------------G---------PQSP------VSQFWS------------------------------------YRWNFQIM--------AAN-DYI-----I----------------------------------------VA------P-N---RR--G----LP---------------GFGVEWNEQISGDYG-----------GQCMKD--YFTA----------------------------------------------I-----------------------------D--EMAKE--SY------------------------------------------V-------DKD--------------------------------------------------------R----L-GC--V-G--AS-----------------FG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-SVY------------------------------------------WLAGH------------------------H--DKRFKA-------------F--IAH------------------------------------------D-----GIFNMEM-----------------Q------------------------------------------------------------YLETE-EKWFANWDMG---G-----AYW--EK-----------------------------------------------QNPIAQRT---------FANSP----H--LF-------------------------------------------------V--EKW-DT--------------------------------------------P------------------------------------------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CI-H-----GEKDF--RILA-NQAM-----------AAF-DA-A-----VMR-----------------GV-------P-------------AELLIY--PD-------------E------------------------------------NHWVLK--------PQNGVLW---QRTFFEWLDKW---------------------------------- 942
943 -------------------IGKVEERWSKTSDGKDLLSWIVLPPHF--DANK-----------K---YP-----T-LLF----C-------E---------------------------------------------------------G--------------------G---------PQSP------VSQFWS------------------------------------YRWNLQIM--------AAN-GYI-----I----------------------------------------VA------P-N---RR--G----LP---------------GFGSDWNAEISGDWT-----------GQCMKD--YLSA----------------------------------------------I-----------------------------D--DAANH-LPY------------------------------------------V-------DKD--------------------------------------------------------R----L-GA--V-G--AS-----------------FG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-SVY------------------------------------------YLASH------------------------H--NKRFKC-------------F--ISH------------------------------------------D-----GAFNLES-----------------M------------------------------------------------------------YTDTE-EAWFSNWEYD---D-----AYW--NKD----------------------------------------------QTANAKRT---------YDNSP----H--KF-------------------------------------------------V--DQW-DT--------------------------------------------P------------------------------------------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CI-H-----GEKDY--RINA-NQGM-----------GAF-NA-A-----RLR-----------------GI-------P-------------AELLIF--PD-------------E------------------------------------NHWVLK--------P------------------------------------------------------ 943
944 ------------------------------------------PPDF--DKNK-----------K---YP-----A-ILY----C-------Q---------------------------------------------------------G--------------------G---------PQNT------VSQFWS------------------------------------FRWNLRLM--------AEQ-GYI-----V----------------------------------------IA------P-N---RH--G----VP---------------GFGQKWNEQISGDYG-----------GQNMRD--YLTA----------------------------------------------V-----------------------------D--EMKKE--PY------------------------------------------V-------DGD--------------------------------------------------------R----I-GA--V-G--AS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-SVY------------------------------------------WLAGH------------------------H--DKRFAA-------------F--IAH------------------------------------------A-----GIFNLEM-----------------Q------------------------------------------------------------YATTE-EMWFANWDIG---G-----PFW--EK-----------------------------------------------DNVVAQRT---------YATSP----H--KY-------------------------------------------------V--QNW-DT--------------------------------------------P------------------------------------------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MI-H-----GELDF--RILA-SQAM-----------AAF-DA-A-----QLR-----------------GV-------P-------------SEMLIY--PD-------------E------------------------------------NHWVLQ--------PQNALLF---HRT------------------------------------------ 944
945 ------------------------------TDGGNMLTWVVLPPDF--DKNK-----------K---YP-----A-ILY----C-------Q---------------------------------------------------------G--------------------G---------PQNT------VSQFWS------------------------------------FRWNLRLM--------AEQ-GYI-----V----------------------------------------IA------P-N---RH--G----VP---------------GFGQKWNEQISGDYG-----------GQNMRD--YLTA----------------------------------------------V-----------------------------D--EMKKE--PY------------------------------------------V-------DGD--------------------------------------------------------R----I-GA--V-G--AS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-SVY------------------------------------------WLAGH------------------------H--DKRFAA-------------F--IAH------------------------------------------A-----GIFNLEM-----------------Q------------------------------------------------------------YATTE-EMWFANWDIG---G-----PFW--EK-----------------------------------------------DNVVAQRT---------YATSP----H--KY-------------------------------------------------V--QNW-DT--------------------------------------------P------------------------------------------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MI-H-----GELDF--RILA-SQAM-----------AAF-DA-A-----QLR-----------------GV-------P-------------SEMLIY--PD-------------E------------------------------------NHWVLQ--------PQNALLF---HRTFFGW-------------------------------------- 945
946 ---------------------------------------VVLPPHF--DPNK-----------K---YP-----A-ILY----C-------Q---------------------------------------------------------G--------------------G---------PQST------VSQFWS------------------------------------YRWNLRTF--------ASH-GYI-----M----------------------------------------VA------P-N---RR--G----VP---------------GFGKEWNEQISGDWG-----------GQNMKD--LLTA----------------------------------------------I-----------------------------D--EVAKE--PY------------------------------------------V-------DAD--------------------------------------------------------R----L-GC--T-G--AS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-TTY------------------------------------------WMAGH------------------------H--EGRFKA-------------L--AAH------------------------------------------A-----GIFNFDA-----------------Q------------------------------------------------------------YLETE-EKFFADWDMG---G-----AYW--E------------------------------------------------DNATTRHT---------YANSP----H--RF-------------------------------------------------V--DKW-DT--------------------------------------------P------------------------------------------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VT-H-----GDRDY--RILS-SQGF-----------MAF-DA-A-----KLR-----------------GI-------P-------------ARILYY--PD-------------E------------------------------------SHWILQ--------PQNGILF---YRT------------------------------------------ 946
947 -----------------------------------VNGWLMKPAQA--EGKT-----------S---YP-----L-ILS----I-------H---------------------------------------------------------G--------------------G---------PHMM------YGHTY--------------------------------------FHEFQVL--------AAK-GYA-----V----------------------------------------VY------V-N---PR--G----SY---------------GYGQEFVNAVRGDYG-----------GKDYED--VMQA----------------------------------------------V-----------------------------D--EAIKR-DPQ------------------------------------------I-------DPE--------------------------------------------------------R----L-GV--T-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MTN------------------------------------------WIVG-------------------------Q--TNRFKA-------------A--VTQ------------------------------------------R-----SISNWIS-----------------F------------------------------------------------------------HGVSDIGYFFTDWQLE---H-----DMF-----------------------------------------------------ADTEKL---------WDRSP----L--KY-------------------------------------------------A--ANV-ET--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GERDD--RCPI-EQAE-----------QLF-IA-L-----KKI-----------------GK-------E-------------TMLVRF--PK-------------A------------------------------------SHNLSRS-----GHPGQRIKR---LNYISSW-------------------------------------- 947
948 -------------FVGEHAISVPEDIQYVTEDGVTVNGWLMKPAHA--ESKT-----------A---YP-----L-ILN----I-------H---------------------------------------------------------G--------------------G---------PHMM------YGHTY--------------------------------------FHEFQVL--------AAK-GYA-----V----------------------------------------VY------V-N---PR--G----SH---------------GYGQEFVNAVRGDYG-----------GKDYED--VMQA----------------------------------------------V-----------------------------D--EAIKR-DPQ------------------------------------------I-------DPK--------------------------------------------------------R----L-GV--T-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MTN------------------------------------------WIVG-------------------------Q--TSRFKA-------------A--VTQ------------------------------------------R-----SISNWIS-----------------F------------------------------------------------------------HGVSDIGYFFTDWQLE---H-----DMF-----------------------------------------------------ADTEKL---------WDRSP----L--KY-------------------------------------------------A--ANV-ET--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GERDD--RCPI-EQAE-----------QLF-IA-L-----KKM-----------------GK-------E-------------TKLVRF--PK-------------A------------------------------------SHNLSRS-----GHPGQRIKR---L-------------------------------------------- 948
949 ---------------------IPEEIQYATEDGVTVNGWLMKPAQM--EGQT-----------T---YP-----L-ILN----I-------H---------------------------------------------------------G--------------------G---------PHMM------YGHTY--------------------------------------FHEFQVL--------AAK-GYA-----V----------------------------------------VY------I-N---PR--G----SH---------------GYGQEFVNAVRGDYG-----------GKDYDD--VMQA----------------------------------------------V-----------------------------D--EAIKR-DPH------------------------------------------I-------DPK--------------------------------------------------------R----L-GV--T-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MTN------------------------------------------WIVG-------------------------Q--TNRFKA-------------A--VTQ------------------------------------------R-----SISNWIS-----------------F------------------------------------------------------------HGVSDIGFFFTDWQLG---H-----DMF-----------------------------------------------------EDTEML---------WDRSP----L--KY-------------------------------------------------A--ANV-ET--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GERDD--RCPI-EQAE-----------QLF-IA-L-----KKM-----------------GK-------E-------------TMLVRF--PN-------------A------------------------------------SHNLSRT-----GHPRQRIKR---LNYISSW-------------------------------------- 949
950 --------------VSEHTISIPEEIQYATEDGVMVNGWLMKPAQM--EGET-----------T---YP-----L-ILN----I-------H---------------------------------------------------------G--------------------G---------PHMM------YGHTY--------------------------------------FHEFQVL--------AAK-GYA-----V----------------------------------------VY------I-N---PR--G----SH---------------GYGQEFVNAVRGDYG-----------GKDYDD--VMQA----------------------------------------------V-----------------------------D--EAIKR-DPH------------------------------------------I-------DPK--------------------------------------------------------R----L-GV--T-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MTN------------------------------------------WIVG-------------------------Q--TNRFKA-------------A--VTQ------------------------------------------R-----SISNWIS-----------------F------------------------------------------------------------HGVSDIGYFFTDWQLE---H-----DMF-----------------------------------------------------EDTEKL---------WDRSP----L--KY-------------------------------------------------A--ANV-ET--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GERDD--RCPI-EQAE-----------QLF-IA-L-----KKM-----------------GK-------E-------------TMLVRF--PK-------------A------------------------------------SHNLSRT-----GHPRQRIKR---L-------------------------------------------- 950
951 GQEEKQLTGANDKFVREHTISIPEEIQYATEDGVMVNGWLMRPAQM--EGET-----------T---YP-----L-ILN----I-------H---------------------------------------------------------G--------------------G---------PHMM------YGHTY--------------------------------------FHEFQVL--------AAK-GYA-----V----------------------------------------VY------I-N---PR--G----SH---------------GYGQEFVNAVRGDYG-----------GKDYDD--VMQA----------------------------------------------V-----------------------------D--EAIKR-DPH------------------------------------------I-------DPK--------------------------------------------------------R----L-GV--T-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MTN------------------------------------------WIVG-------------------------Q--TNRFKA-------------A--VTQ------------------------------------------R-----SISNWIS-----------------F------------------------------------------------------------HGVSDIGYFFTDWQLE---H-----DMF-----------------------------------------------------EDTEKL---------WDRSP----L--KY-------------------------------------------------A--ANV-ET--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GERDD--RCPI-EQAE-----------QLF-IA-L-----KKM-----------------GK-------E-------------TKLVRF--PN-------------A------------------------------------SHNLSR--------------------------------------------------------------- 951
952 --------------------------------------WLLKPARF--EEDK-----------K---YP-----L-ILN----I-------H---------------------------------------------------------G--------------------G---------PHMM------YGNTY--------------------------------------FHEFQVL--------AAK-GYA-----V----------------------------------------VY------V-N---PR--G----SH---------------GYGQTFVNAVRGDYG-----------GKDYED--VMQA----------------------------------------------V-----------------------------D--EVISA-HSF------------------------------------------V-------DTE--------------------------------------------------------R----L-GV--T-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MTN------------------------------------------WIVG-------------------------H--TNRFKA-------------A--VTQ------------------------------------------R-----SISNWLS-----------------F------------------------------------------------------------HGVSDIGFFFTDWQLG---H-----DMF-----------------------------------------------------EDAEKL---------WDRSP----L--KY-------------------------------------------------A--KQV-ET--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GERDD--RCPV-EQAE-----------QLF-TA-L-----KKM-----------------NK-------E-------------TVFVRF--PG-------------A------------------------------------SHNLSRS-----GHPKQRIKR---LGYI----------------------------------------- 952
953 ----------------------------------TVHGWFLKPAAF--EEDQ-----------T---YP-----L-ILY----I-------H---------------------------------------------------------G--------------------G---------PHMM------YGHTY--------------------------------------FHEFQVL--------AAQ-GYA-----V----------------------------------------VY------V-N---PR--G----SH---------------GYGQDFVNRVRGDYG-----------GGDYRD--VMQA----------------------------------------------V-----------------------------D--EAIQA-YPF------------------------------------------I-------DSG--------------------------------------------------------R----L-GV--T-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MTN------------------------------------------WIVG-------------------------Q--TDRFKA-------------A--VTQ------------------------------------------R-----SISNWFS-----------------F------------------------------------------------------------HGVSDIGFFFTDWQLG---H-----DLF-----------------------------------------------------EEADKL---------WDRSP----V--KY-------------------------------------------------A--SRV-ST--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GERDD--RCPI-EQAE-----------QLF-TA-L-----KKL-----------------NK-------T-------------TAFIRF--PK-------------A------------------------------------THELSRS-----GHPEQRMKR---IRYIRSW-------------------------------------- 953
954 ----------------------------------EVQGWTLHPPDF--DPAQ-----------R---YP-----L-AVY----I-------H---------------------------------------------------------G--------------------G---------PHIM------WGPGFR-----------------------------------SMWHEWQVA--------AAR-GYV-----V----------------------------------------FF------C-N---PR--G----SE---------------GYGELWRDAIRGNWG-----------EADAPD--ILAG----------------------------------------------I-----------------------------D--ALVAR--GY------------------------------------------I-------DPE--------------------------------------------------------R----I-GV--T-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTA------------------------------------------WLIG-------------------------H--DDRFAC-------------A--VAA------------------------------------------R-----GVYNLLT-----------------Q------------------------------------------------------------HSTSD-AHELIEIEFG---G-----FPW-----------------------------------------------------ELYEEL---------WDHSP----L--AH-------------------------------------------------A--HKI-KT--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----SELDY--RVPI-SEAE-----------QLF-AI-L-----RRQ-----------------KK-------V-------------VELVRY--PR-------------E------------------------------------GHELTRS-----GEPRHRADH---MRRTLEW-------------------------------------- 954
955 -----------------------EEITYLAPDGSEVQGWTLHPPDF--DPAQ-----------R---YP-----L-AVY----I-------H---------------------------------------------------------G--------------------G---------PHIM------WGPGFR-----------------------------------SMWHEWQVA--------AAR-GYV-----V----------------------------------------FF------C-N---PR--G----SE---------------GYGELWRDAIRGNWG-----------EADAPD--ILAG----------------------------------------------I-----------------------------D--ALVAR--GY------------------------------------------I-------DPE--------------------------------------------------------R----I-GV--T-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTA------------------------------------------WLIG-------------------------H--DDRFAC-------------A--VAA------------------------------------------R-----GVYNLLT-----------------Q------------------------------------------------------------HSTSD-AHELIEIEFG---G-----FPW-----------------------------------------------------ELYEEL---------WDHSP----L--AH-------------------------------------------------A--HKI-KT--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----SELDY--RVPI-SEAE-----------QLF-AI-L-----RRQ-----------------KK-------V-------------VELVRY--PR-------------E------------------------------------GHELTRS-----GEPRHRADH---MRRTLEWFDRY---------------------------------- 955
956 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E--------------------------------------------------------R----V-GV--A-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MVN------------------------------------------WLTAR------------------------H--PHRFRA-------------A--VTD------------------------------------------R-----SICNWFS-----------------F------------------------------------------------------------FGASDIGPRFTFLEL---FA-----TPW-----------------------------------------------------EAPEVL---------WEKSP----L--RL-------------------------------------------------A--HQV-KT--------------------------------------------P------------------------------------------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-H-----AEQDH--RCPI-DQGE-----------AWY-TA-L-----LHL-----------------GV-------K-------------TRFFRV--PE-------------E------------------------------------GHELS---------------------------------------------------------------- 956
957 -----------------------------------VPGFVLLP-----EGEG-----------P---HP-----L-ILY----I-------H---------------------------------------------------------G--------------------G---------PHTA------FGRAP--------------------------------------MLELALF--------QKA-GYA-----V----------------------------------------AF------A-N---PR--G----ST---------------GYGQDYA-LLEGAWG-----------ERDEED--LLGF----------------------------------------------L-----------------------------D--HVLAR-FP-------------------------------------------L-------DPE--------------------------------------------------------R----V-GV--A-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MVN------------------------------------------WLTAR------------------------H--PHRFRA-------------A--VTD------------------------------------------R-----SICNWFS-----------------F------------------------------------------------------------FGASDIGPRFTFLEL---FA-----TPW-----------------------------------------------------EAPEVL---------WEKSP----L--RL-------------------------------------------------A--HQV-KT--------------------------------------------P------------------------------------------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-H-----AEQDH--RCPI-DQGE-----------AWY-TA-L-----LHL-----------------GV-------K-------------TRFFRV--PE-------------E------------------------------------GHELSRS-----GRPDRRVAR---LRAYLDW-------------------------------------- 957
958 ----------------------------FETELGEGEGWVLLP-----EGEQ-----------K---VP-----A-LLN----I-------H---------------------------------------------------------G--------------------G---------PHTD------YGHGF--------------------------------------THEFQLM--------AAR-GYG-----V----------------------------------------CY------S-N---PR--G----SV---------------GYGQAWVDAIYGRWG-----------TVDADD--LLNF----------------------------------------------F-----------------------------D--RCLEA-VPR------------------------------------------L-------DAA--------------------------------------------------------K----T-AV--M-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MTN------------------------------------------WITG-------------------------H--TTRFQA-------------A--ITD------------------------------------------R-----CISNLIS-----------------F------------------------------------------------------------GGTSDIGLRFWDDELGLDFS-----RRA-----------------------------------------------------DALK-L---------WDLSP----L--QY-------------------------------------------------V--ENV-KT--------------------------------------------P------------------------------------------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-H-----SVLDH--RCPV-EQAE-----------QWY-AA-L-----HKH-----------------QV-------P-------------VRFVRF--PE-------------E------------------------------------NHELSRS-----GRPDRRLTR---LNEYFAWLERW---------------------------------- 958
959 ----------------------------VQSGDVTLDGWYIEPLNC--QPGK-----------K---YP-----T-ILN----I-------H---------------------------------------------------------G--------------------G---------PRGV------YGDVF--------------------------------------FHEMQCW--------AAQ-GYG-----V----------------------------------------IF------T-N---PR--G----SD---------------GRGNDFDD-IRGAYG-----------VTDYGD--LMAF----------------------------------------------A-----------------------------E--WCAAH-LPF------------------------------------------V-------DSD--------------------------------------------------------R----L-GV--A-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MVN------------------------------------------WMVT-------------------------H--TDRFKA-------------A--CAQ------------------------------------------R-----PISNWVS-----------------K------------------------------------------------------------FGSCDIGYYYVEDQHV---G-----LPW-----------------------------------------------------DGRPGP---------WDDSP----L--KY-------------------------------------------------A--ANA-KT--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-Q-----SSDDF--RCEA-SQSF-----------QMF-TA-M-----KVL-----------------GV-------P-------------CRMCFF--HG-------------E------------------------------------NHELSR--------------------------------------------------------------- 959
960 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-----------------------------E-----------------------------------------------------------------------------------------------------------------------------L-FV--T-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTN------------------------------------------WIVG-------------------------H--TDRFKA-------------A--CAQ------------------------------------------R-----SISNWTS-----------------M------------------------------------------------------------YGSTDIGFFFVDDQHV--EG-----TPW-----------------------------------------------------DYPERY---------WNDSP----L--KF-------------------------------------------------A--ANI-KT--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----SDKDM--RCDM-NQAT-----------QIF-TA-L-----KVR-----------------GV-------E-------------CRFCLF--HE-------------E------------------------------------THELS---------------------------------------------------------------- 960
961 -----------------------PEVFDFITNGDTTKGFVIYPIDY--DKNK-----------T---YP-----A-ILD----I-------H---------------------------------------------------------G--------------------G---------PKTV------YGDVY--------------------------------------YHEMQVW--------ANM-GYF-----V----------------------------------------IF------T-N---PH--G----SD---------------GYGNKFAD-IRGKYG-----------TIDYED--LMNF----------------------------------------------T-----------------------------D--YVLEK-YP-------------------------------------------I-------DKS--------------------------------------------------------R----V-GV--T-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTN------------------------------------------WIIG-------------------------H--TDRFKC-------------A--ASQ------------------------------------------R-----SISNWIS-----------------K------------------------------------------------------------FGTTDIGYYFNADQNQ---A-----TPW-----------------------------------------------------INHDKL---------WWHSP----L--KY-------------------------------------------------A--DKA-KT--------------------------------------------P------------------------------------------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-H-----SEEDY--RCWL-AEGL-----------QMF-TA-L-----KYH-----------------GI-------E-------------ARLCMF--RG-------------E------------------------------------NHELSRS-----GKPKHRIRR---LTEITNWFEKY---------------------------------- 961
962 ------------------------------------KGFVIYPIDY--DKNK-----------T---YP-----A-ILD----I-------H---------------------------------------------------------G--------------------G---------PKTV------YGDVY--------------------------------------YHEMQVW--------ANM-GYF-----V----------------------------------------IF------T-N---PH--G----SD---------------GYGNKFAD-IRGKYG-----------TIDYED--LMNF----------------------------------------------T-----------------------------D--YVLEK-YP-------------------------------------------I-------DKS--------------------------------------------------------R----V-GV--T-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTN------------------------------------------WIIG-------------------------H--TDRFKC-------------A--ASQ------------------------------------------R-----SISNWIS-----------------K------------------------------------------------------------FGTTDIGYYFNADQNQ---A-----TPW-----------------------------------------------------INHDKL---------WWHSP----L--KY-------------------------------------------------A--DKA-KT--------------------------------------------P------------------------------------------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-H-----SEEDY--RCWL-AEGL-----------QMF-TA-L-----KYH-----------------GI-------E-------------ARLCMF--RG-------------E------------------------------------NHELS---------------------------------------------------------------- 962
963 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S--------------------------------------------------------R----V-GV--T-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTN------------------------------------------WIIG-------------------------H--TDRFKC-------------A--ASQ------------------------------------------R-----SISNWIS-----------------K------------------------------------------------------------FGTTDIGYYFNADQNQ---A-----TPW-----------------------------------------------------INHDKL---------WWHSP----L--KY-------------------------------------------------A--DKA-KT--------------------------------------------P------------------------------------------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-H-----SEEDY--RCWL-AEGL-----------QMF-TA-L-----KYH-----------------GV-------E-------------ARLCMF--RG-------------E------------------------------------NHELSRS-----GKPKHRIRR---LTEITNWFEKY---------------------------------- 963
964 -----LKYRDIEYDPNPNIKGYTPERITVNSNGVEVEGWSII-------KDP-----------N---AP-----T-ILF----I-------H---------------------------------------------------------G--------------------G---------PHMA------YGYGY--------------------------------------FIEFQFF--------VDN-GFN-----V----------------------------------------IY------A-N---PR--G----SQ---------------GYGEEFAKACVGDWG-----------GKDFED--LMNF----------------------------------------------V-----------------------------N--TVKER-YSL---------------------------------------------------KG--------------------------------------------------------K----F-GI--T-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MTN------------------------------------------WIVT-------------------------K--TSMFSA-------------A--ISE------------------------------------------R-----SISNLVS-----------------M------------------------------------------------------------CGTSDIGFWFNAIESG--IA-----DPW---------------------------------------------------STEGIEKL---------MKMSP----I--YY-------------------------------------------------V--KNV-KT--------------------------------------------P------------------------------------------------------------TM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GEEDY--RCPI-EQAE-----------QFY-VA-L-----KMQ-----------------GV-------P-------------TTLVRY--QG-------------D------------------------------------SHEHARR-----GKPKNMIDR---LKTKLEWFSKY---------------------------------- 964
965 -----------------------------------IEGWLMKPYGY--EAGK-----------K---YP-----M-VIY----I-------H---------------------------------------------------------G--------------------G---------PHSS------YGEGW--------------------------------------FDEFQNL--------AAQ-GMF-----V----------------------------------------LF------T-N---PR--G----SS---------------GYGAPFTYSTRGRWG-----------MEDYQD--LMKA----------------------------------------------V-----------------------------D--IVSVR--AD------------------------------------------V-------DST--------------------------------------------------------K----M-GA--T-G--GS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MTT------------------------------------------WMAT-------------------------K--TTRFKA-------------I--ETD------------------------------------------R-----TITDWTY-----------------W------------------------------------------------------------YG-SSDAQGLTEFEFY---G-----KPW-----------------------------------------------------DNQKLY---------DELSP----I--RY-------------------------------------------------V--NKV-KT--------------------------------------------P------------------------------------------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-Q-----SEEDH--RTPM--GSA-----------EIWFMS-L-----KKQ-----------------GV-------P-------------VELIRY--PR-------------S------------------------------------NHDLSRT-----GEPWLLVDR---LGRLRQW-------------------------------------- 965
966 ---------------------------------LEIDGWYMKP-EL--KEGE-----------K---AP-----V-IVF----V-------H---------------------------------------------------------G--------------------G---------PKGM------YGYYF--------------------------------------KYEMQLM--------AAK-GYY-----I----------------------------------------VY------V-N---PR--G----SN---------------GYSEDFALRVLTRTG-----------LEDFQD--ILNG----------------------------------------------I-----------------------------E--EFLKL-EPQ------------------------------------------A-------DRE--------------------------------------------------------R----I-GI--T-G--IS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTN------------------------------------------WALT-------------------------Q--SDLFKA-------------G--ISE------------------------------------------N-----GISYWLT-----------------S------------------------------------------------------------YAFSDIGLWFDKEVIG---E-----NPL---------------------------------------------------ENENFRRL------------SP----L--FY-------------------------------------------------A--KNV-KA--------------------------------------------P------------------------------------------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----SLEDY--RCPL-DQSL-----------MFY-HV-L-----KDL-----------------GK-------E-------------AYIAIF--KR-------------G------------------------------------AHGHSIR-----GQPRHRMKR---YKLFVEF-------------------------------------- 966
967 -----------------------------------VQSWLIKPPGF--DASK-----------K---YP-----I-LLE----I-------H---------------------------------------------------------G--------------------G---------PFLG------YGDRF------------------------------------D--LEKQAL--------AGA-GYL-----V----------------------------------------LY------V-N---PR--G----ST---------------SYGEKFANGIHHDYP-----------NFDRLD--LESA----------------------------------------------V-----------------------------D--AVIAK--GI------------------------------------------V-------DTT--------------------------------------------------------R----L-YV--A-G--GS-----------------GG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-LTA------------------------------------------WITS-------------------------Y--THRYRA-------------A--VVE------------------------------------------Y-----PVINWTS-----------------W------------------------------------------------------------LWTADTPRGTTTW----FPG-----APW-----------------------------------------------------DHEAQY---------AKRSP----L--SR-------------------------------------------------V--QFV-KT--------------------------------------------P------------------------------------------------------------TM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VL-T-----GELDY--RTPM-SESE-----------QWY-SA-L-----RFR-----------------GV-------E-------------AVLVKV--PG-------------E------------------------------------PHGIRES-------PSHWLQK---MAYVQGW-------------------------------------- 967
968 -----------------------------------IQGWIVKPADF--DPSK-----------K---YP-----L-MLE----I-------H---------------------------------------------------------G--------------------G---------PHSM------YNVAF------------------------------------N--FSRQDH--------VAH-GYV-----L----------------------------------------LY------T-N---PR--G----ST---------------GYGSAFGNAIKNAYP-----------GKDYDD--LMAG----------------------------------------------V-----------------------------D--TVIGR--GY------------------------------------------V-------DTN--------------------------------------------------------R----L-YV--F-G--CS-----------------GG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-LTS------------------------------------------WIVG-------------------------H--TDRFSA-------------A--SAN------------------------------------------C-----PVTNWIS-----------------F------------------------------------------------------------VGTTD----GSNWYYN-FAK-----YPW-----------------------------------------------------DDPSEH---------LRRSP----L--MY-------------------------------------------------V--GNV-KT--------------------------------------------P------------------------------------------------------------TM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-T-----GVNDL--RTPM-AQTE-----------EYY-EA-L-----KIR-----------------KV-------P-------------TAMVRF--NN-------------E------------------------------------WHGTSST-------PSNFLRT---QLYLRSW-------------------------------------- 968
969 -----------------------------------VEGVLLLPVGY--QEGN-----------K---VP-----L-VVS----A-------H---------------------------------------------------------G--------------------G---------PTGV------HTNGFK-----------------------------------LGNDPGQTW--------AAR-GWA-----V----------------------------------------LY------P-N---PR--G----ST---------------GYGEWWMRANTGDWG-----------GGDYRD--IMTG----------------------------------------------V-----------------------------D--DLIKR--GI------------------------------------------A-------DST--------------------------------------------------------R----M-AF--E-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTS------------------------------------------WVVS-------------------------Q--TGRFKA-------------A--MMG------------------------------------------A-----GLPSLLS-----------------M------------------------------------------------------------AGTTDIPGYINTF-----FG-----QP-------------------------------------------------------QYDGSIVNPSIRKFLERSG----I--SY-------------------------------------------------S--DRI-TT--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GSNDE--RVPI-GQPM-----------EFY-RA-L-----KDR-----------------GK-------T-------------TELVFY--PR-------------E------------------------------------GHGFTEY-----YHQLDRMKR---EYEW----------------------------------------- 969
970 -----------------------------------LQGLLYLPPQA--SSAH-----------R---VP-----L-IVD----V-------H---------------------------------------------------------G--------------------G---------PTGAWQDDYFAFNEFL-----------------------------------LGH------------------GWA-----V----------------------------------------FE------P-N---PR--G----ST---------------GYGASFVAANHNDLG-----------GGDYRD--IMTG----------------------------------------------V-----------------------------D--AVIAH--DP------------------------------------------I-------DAQ--------------------------------------------------------K----L-VL--M-G--YS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-MAG------------------------------------------FVEG-------------------------K--TTRFKA-------------I--IAG------------------------------------------A-----PVIDQES-----------------E------------------------------------------------------------YGTEDGSWYDRWF-----YG-----LPW-----------------------------------------------------ERSDAA---------WRQSP----L--SF-------------------------------------------------A--AHA-HT--------------------------------------------P------------------------------------------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-Q-----GMADT--TDPK-GQSE-----------EMY-RA-L-----RQM-----------------GV-------P-------------VDLVEY--PR-------------D------------------------------------NHG-----------SLAR--------------------------------------------------- 970
971 ------------------------ESVQWTNDGLHVQGWLLYPKNY--DPAK-----------K---YP-----L-IVY----V-------H---------------------------------------------------------G--------------------GPAYANLAHWPYAG------YGPVP--------------------------------------F--------------SAL-GYF-----V----------------------------------------LM------P-N---PR--G----SY---------------GEGERFTKANRKDFG-----------YGDLRD--ILAG----------------------------------------------V-----------------------------D--AVEKQ--VP------------------------------------------I-------DNH--------------------------------------------------------R----V-GL--T-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MTM------------------------------------------FAVT-------------------------Q--TQRFHA-------------A--VAG------------------------------------------A-----GISDWKS-----------------Y------------------------------------------------------------YGENSIDQWMIPF-FG---A-----SVY-----------------------------------------------------NDPAVY---------AKSSA----I--NF-------------------------------------------------I--KNV-KT--------------------------------------------P------------------------------------------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-V-----GSNDK--ECPA-PQSY-----------EFW-HA-L-----RAM-----------------HV-------P-------------TELVVY--AG-------------E------------------------------------GHGFYKP-----------ADRRNVLERALAW-------------------------------------- 971
972 -----------------------------------VGGVLIKPVGY--QAGK-----------K---YP-----L-LVA----I-------H---------------------------------------------------------G--------------------G---------PAAA------DLLSF------------------------------------NGGYGAQTY--------AGK-GWV-----V----------------------------------------LM------P-N---YR--G----ST---------------NYGEAHKVGIVGNYF-----------PPGYND--IMTG----------------------------------------------V-----------------------------D--ALIGQ--GL------------------------------------------V-------DST--------------------------------------------------------K----M-GV--L-G--WS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-WSN------------------------------------------WIVT-------------------------H--TNRFKA-------------I--SSG------------------------------------------A-----GTSNWIS-----------------M------------------------------------------------------------YAQSDMQRNRQHYLGD---K-----LPY-----------------------------------------------------DDFEAY---------WRQSP----I--RY-------------------------------------------------I--RAA-KT--------------------------------------------P------------------------------------------------------------TM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IH-V-----VEGDP--RVPS-PQSV-----------ELH-MG-L-----KRV-----------------GV-------P-------------TELFMY--PG-------------A------------------------------------SHGI----------------------------------------------------------------- 972
973 ----------------------------------VVEGWYYLPPQF--DPSK-----------K---YP-----M-LVY----Y-------Y---------------------------------------------------------G--------------------G----------TSP------INRTLE------------------------------------GHYSLAMY--------AAQ-GYV-----V----------------------------------------YT------L-N---PS--G----TT---------------GYGQEYAARHVNAWG-----------DRTADE--IIGA----------------------------------------------T-----------------------------K--EFIRT-HSF------------------------------------------V-------NGK--------------------------------------------------------K----V-GC--F-G--AS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MTQ------------------------------------------YLQTK------------------------T---DIFAA-------------A--VSH------------------------------------------A-----GISSISN-----------------Y------------------------------------------------------------WGS----------------------GYWGMGYS----------------------------------------------TVASTDSY---------PWNNP----D--LYAGHS-----------------------------------------PLFRA--DKI-HT--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GSVDT--NVPT-AESV-----------NLY-NA-L-----KIL-----------------GR-------E-------------VEFIEF--TE-------------Q------------------------------------DHFILE--------PERRIRW---TNSICAW-------------------------------------- 973
974 ----------------------------------VITGKMCLPPNF--DPNK-----------K---YP-----M-IVY----Y-------Y---------------------------------------------------------G--------------------G----------TTP------TTRGIS------------------------------------NPYCAQLF--------ASR-DYV-----V----------------------------------------YV------I-Q---PS--G----TI---------------GFGQEFSARHVNAWG-----------KRTADD--IIEG----------------------------------------------T-----------------------------K--QFCKE-HPF------------------------------------------V-------DEK--------------------------------------------------------K----I-GC--L-G--AS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MTQ------------------------------------------YLQTQ------------------------T---DIFAA-------------A--VSH------------------------------------------A-----GISDVTS-----------------Y------------------------------------------------------------WGE----------------------GYWGYSYN----------------------------------------------AIAAADSY---------PWKDP----D--LFTKQG-----------------------------------------SLFNA--DKI-NT--------------------------------------------P------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GTVDT--NVPI-GESI-----------QLF-NA-L-----KIL-----------------GK-------T-------------VEFVTV--DG-------------E------------------------------------NHFISD--------YDKRIKW---HNSIMAW-------------------------------------- 974
975 ------------------------------------YAMVFKPHN------FEL---------GVK-YP-----T-VLN----V-------Y---------------------------------------------------------G--------------------GP--------------------------------EVQTVNNTFKG-K-HQ-LRM----HMLA--AQ----------------GYC-----V----------------------------------------IC------I-D---SR-GS--------------RH------RGKRFESHIRGRMG-----------QVELTD--QVDA----------------------------------------------L-----------------------------R--SLSDQ---------------------------------------L-GY---I-------DMD--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMGLV-----Q--------------YP--------------K--IFKV----------------------------------------------A--IAG------------------------------------------A-----PVTNWEYY----------------DTGYTERYMDMP--QNNEAG-----------------------------------------YSAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------L--EYV-----------------------------------------------NSFPEED-K--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GLIDE--NVHF-CHTS-----------RLI-SA-L-----NKA-----------------NK---PYEVH------------L-----F--PE-------------E------------------------------------RHSLRN-LESNKNYETKLLSFLQ---------------------------------------------- 975
976 ------------------QYCPQIFSPQ-LPSGDIVYAMVFKPHN------FEL---------GVK-YP-----T-VLN----V-------Y---------------------------------------------------------G--------------------GP--------------------------------EVQTVNNTFKG-K-HQ-LRM----HMLA--AQ----------------GYC-----V----------------------------------------IC------I-D---SR-GS--------------RH------RGKRFESHIRGRMG-----------QVELTD--QVDA----------------------------------------------L-----------------------------R--SLSDQ---------------------------------------L-GY---I-------DMD--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMGLV-----Q--------------YP--------------K--IFKV----------------------------------------------A--IAG------------------------------------------A-----PVTNWEYY----------------DTGYTERYMDMP--QNNEAG-----------------------------------------YSAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------L--EYV-----------------------------------------------NSFPEED-K--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GLIDE--NVHF-CHTS-----------RLI-SA-L-----NKA-----------------NK---PYEVH------------L-----F--PE-------------E------------------------------------RHSLRN-LESNKNYETKLLSFLQN--------------------------------------------- 976
977 ------------------------------------YAMVFKPHN------FEL---------GVK-YP-----T-VLN----V-------Y---------------------------------------------------------G--------------------GP--------------------------------EVQTVNNTFKG-K-HQ-LRM----HMLA--AQ----------------GYC-----V----------------------------------------IC------I-D---SR-GS--------------RH------RGKRFESHIRGRMG-----------QVELTD--QVDA----------------------------------------------L-----------------------------R--SLSDQ---------------------------------------L-GY---I-------DMD--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMGLV-----Q--------------YP--------------K--IFKV----------------------------------------------A--IAG------------------------------------------A-----PVTNWEYY----------------DTGYTERYMDMP--QNNEAG-----------------------------------------YSAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------L--EYV-----------------------------------------------NSFPEED-K--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GLIDE--NVHF-CHTS-----------RLI-SA-L-----NKA-----------------NK---PYEVH------------L-----F--PE-------------E------------------------------------RHSLRN-LESNKNYETKLLSFLQ---------------------------------------------- 977
978 ----------------NTQYNPSIHSPQ-ISSGDVLYAMVFKPHN------FML---------GVK-YP-----T-VLN----V-------Y---------------------------------------------------------G--------------------GP--------------------------------EVQTVSNTFKG-M-RQ-LRM----HMLA--SQ----------------GYC-----V----------------------------------------IC------V-D---SR-GS--------------RH------RGVEFESYIRCRMG-----------TVELSD--QVEV----------------------------------------------L-----------------------------R--ILADQ---------------------------------------L-GY---I-------DMD--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMGLV-----Q--------------YP--------------E--IFKV----------------------------------------------S--IAG------------------------------------------A-----PVTSWEYY----------------DTGYTERYMDLP--DSNRSG-----------------------------------------YAAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------L--NYI-----------------------------------------------QKFPDED-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-H-----GLIDE--NVHF-HHTS-----------QLV-SR-L-----VRA-----------------NK---PYQLQ------------V-----Y--PN-------------E------------------------------------RHSLRN-LEASKHYETKLLSFLQN--------------------------------------------- 978
979 ------------------------FSHV-ISSGDRLHGMIFRPHN------YRP---------GTK-YP-----T-VLN----I-------Y---------------------------------------------------------G--------------------GP--------------------------------EVQLVTNTFKG-L-RQ-LRL----HMLA--AL----------------GYC-----V----------------------------------------VT------I-D---SR-GS--------------QN------RGVNFESHIKGRLG-----------TVELHD--QVEV----------------------------------------------L-----------------------------Q--WVAET---------------------------------------M-SC---I-------DLN--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLLGLA-----Q--------------YS--------------H--VFKV----------------------------------------------A--IAG------------------------------------------A-----PVTSWNLY----------------DTGYTERYLGQP--QTNQIG-----------------------------------------YKNGSV---------------------------------------------------------------------------------------------------------------------------------------------------------L--SYV-----------------------------------------------NQFPDQE-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-H-----GMIDE--NVHF-AHTS-----------QLI-NA-L-----VRS-----------------GK---PYQLQ------------V-----Y--PN-------------E------------------------------------RHSLRH-LDASEHYETVLLTFLRN--------------------------------------------- 979
980 -------RIVHT-EIPVGYTPPQLFSFT-NKDGIELYGMVFRPHKDGVDLPLND---------GST-YP-----T-VLF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------HVQLVTNSFKG-L-RF-LRL----HTLA--SQ----------------GYA-----V----------------------------------------VV------V-D---AR-GS--------------FR------RGLNFEAHLRHQMG-----------MVELED--QVEA----------------------------------------------L-----------------------------R--WLAER---------------------------------------D-GY---L-------DLN--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSLMGLV-----Q--------------RP--------------D--VFKV----------------------------------------------G--IAA------------------------------------------A-----PVTDWKLY----------------DTGYTERYMGLP--TTNPLG-----------------------------------------YDASSL---------------------------------------------------------------------------------------------------------------------------------------------------------L--KLA-----------------------------------------------DHFPAED-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-H-----GLIDE--NVHF-HHTS-----------ALV-SE-L-----IKQ-----------------GK---PHDLQ------------I-----Y--PN-------------E------------------------------------RHGIR---------------------------------------------------------------- 980
981 ------------------------------------------PSN------LEV---------GKK-YP-----T-VLY----V-------Y---------------------------------------------------------G--------------------GP--------------------------------HVQLVTNSFKG-L-RY-QRL----YTLS--LL----------------GYV-----V----------------------------------------VI------I-D---GR-GS--------------TH------RGLKFESYLKNKMG-----------KVEMDD--QVEG----------------------------------------------L-----------------------------Q--YLSHK---------------------------------------L-NY---M-------DLT--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMGLA-----Q--------------RP--------------D--IFKV----------------------------------------------A--IAG------------------------------------------A-----PVVNWTKY----------------DTGYTERYMGTP--DANPEA-----------------------------------------YDEGSV---------------------------------------------------------------------------------------------------------------------------------------------------------T--RCA-----------------------------------------------ASFPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-H-----GLIDE--NVHF-VHTT-----------DLI-SA-L-----VKC-----------------CK---PYQLQ------------I-----Y--PA-------------E------------------------------------RHGIRN-PDSNEHFEVAVISFLQQ--------------------------------------------- 981
982 -------------------TPPQLFSFT-NSSGDQIHGLYHAPSN------LEV---------GKK-YP-----T-VLY----V-------Y---------------------------------------------------------G--------------------GP--------------------------------HVQLVTNSFKG-L-RY-QRL----YTLS--LL----------------GYV-----V----------------------------------------VI------I-D---GR-GS--------------TH------RGLKFESYLKNKMG-----------KVEMDD--QVEG----------------------------------------------L-----------------------------Q--YLSHK---------------------------------------L-NY---M-------DLT--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMGLA-----Q--------------RP--------------D--IFKV----------------------------------------------A--IAG------------------------------------------A-----PVVNWTKY----------------DTGYTERYMGTP--DANPEA-----------------------------------------YDEGSV---------------------------------------------------------------------------------------------------------------------------------------------------------T--RCA-----------------------------------------------ASFPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-H-----GLIDE--NVHF-VHTT-----------DLI-SA-L-----VKC-----------------CK---PYQLQ------------I-----Y--PA-------------E------------------------------------RHGIRN-PDSNEHFEVAVISFLQQH-------------------------------------------- 982
983 QPEVLVNLLDSS-SGVPDYTPPQLFSFT-NSSGDQIHGLYHAPSN------LEV---------GKK-YP-----T-VLY----V-------Y---------------------------------------------------------G--------------------GP--------------------------------HVQLVTNSFKG-L-RY-QRL----YTLS--LL----------------GYV-----V----------------------------------------VI------I-D---GR-GS--------------TH------RGLKFESYLKNKMG-----------KVEMDD--QVEG----------------------------------------------L-----------------------------Q--YLSHK---------------------------------------L-NY---M-------DLT--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMGLA-----Q--------------RP--------------D--IFKV----------------------------------------------A--IAG------------------------------------------A-----PVVNWTKY----------------DTGYTERYMGTP--DANPEA-----------------------------------------YDEGSV---------------------------------------------------------------------------------------------------------------------------------------------------------T--RCA-----------------------------------------------ASFPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-H-----GLIDE--NVHF-VHTT-----------DLI-SA-L-----VKC-----------------CK---PYQLQ------------I-----Y--PA-------------E------------------------------------RHGIRN-PDSNEHFEVAVISFLQ---------------------------------------------- 983
984 ---------------------------T-NSSGDQIHGLYHAPSN------LEV---------GKK-YP-----T-VLY----V-------Y---------------------------------------------------------G--------------------GP--------------------------------HVQLVTNSFKG-L-RY-QRL----YTLS--LL----------------GYV-----V----------------------------------------VI------I-D---GR-GS--------------TH------RGLKFESYLKNKMG-----------KVEMDD--QVEG----------------------------------------------L-----------------------------Q--YLSHK---------------------------------------L-NY---M-------DLT--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMGLA-----Q--------------RP--------------D--IFKV----------------------------------------------A--IAG------------------------------------------A-----PVVNWTKY----------------DTGYTERYMGTP--DANPEA-----------------------------------------YDEGSV---------------------------------------------------------------------------------------------------------------------------------------------------------T--RCA-----------------------------------------------ASFPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-H-----GLIDE--NVHF-VHTT-----------DLI-SA-L-----VKC-----------------CK---PYQLQ------------I-----Y--PA-------------E------------------------------------RHGIRN-PDSNEHFEVAVISFLQQHL------------------------------------------- 984
985 ------------------------------------------PHG------EEA---------GKK-YP-----T-VVM----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQQVTNCFKG-I-RF-LRH----HALA--SN----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CG------RGLKFESHIKNRLG-----------TVEIED--QVEG----------------------------------------------L-----------------------------Q--YLSSA---------------------------------------G-YC---V-------DMT--------------------------------------------------------R----V-GI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLLGIA-----Q--------------RP--------------D--VFKV----------------------------------------------G--IAG------------------------------------------A-----PVVNWLLY----------------DTGYTERYLNLP--SENEAG-----------------------------------------YRNGSV---------------------------------------------------------------------------------------------------------------------------------------------------------L--SHV-----------------------------------------------DQFPDEE-N--------------------------R-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-H-----GLIDE--NVHF-HHTS-----------ALI-TA-L-----VKA-----------------CK---PYRLQ------------I-----Y--PN-------------E------------------------------------RHGIRN-HEASEHYKTMILSFLQ---------------------------------------------- 985
986 ------IKNRLV-SACPDYNAPELFQYQ-SQSGFTHHGLFFHPHG------EEA---------GKK-YP-----T-VVM----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQQVTNCFKG-I-RF-LRH----HALA--SN----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CG------RGLKFESHIKNRLG-----------TVEIED--QVEG----------------------------------------------L-----------------------------Q--YLSSA---------------------------------------G-YC---V-------DMT--------------------------------------------------------R----V-GI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLLGIA-----Q--------------RP--------------D--VFKV----------------------------------------------G--IAG------------------------------------------A-----PVVNWLLY----------------DTGYTERYLNLP--SENEAG-----------------------------------------YRNGSV---------------------------------------------------------------------------------------------------------------------------------------------------------L--SHV-----------------------------------------------DQFPDEE-N--------------------------R-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-H-----GLIDE--NVHF-HHTS-----------ALI-TA-L-----VKA-----------------CK---PYRLQ------------I-----Y--PN-------------E------------------------------------RHGIRN-HEA----------------------------------------------------------- 986
987 -----------------------------SQSGFTHHGLFFHPHG------EEA---------GKK-YP-----T-VVM----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQQVTNCFKG-I-RF-LRH----HALA--SN----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CG------RGLKFESHIKNRLG-----------TVEIED--QVEG----------------------------------------------L-----------------------------Q--YLSSA---------------------------------------G-YC---V-------DMT--------------------------------------------------------R----V-GI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLLGIA-----Q--------------RP--------------D--VFKV----------------------------------------------G--IAG------------------------------------------A-----PVVNWLLY----------------DTGYTERYLNLP--SENEAG-----------------------------------------YRNGSV---------------------------------------------------------------------------------------------------------------------------------------------------------L--SHV-----------------------------------------------DQFPDEE-N--------------------------R-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-H-----GLIDE--NVHF-HHTS-----------ALI-TA-L-----VKA-----------------CK---PYRLQ------------I-----Y--PN-------------E------------------------------------RHGIRN-HEASEHYKTMILSFLQNHL------------------------------------------- 987
988 TSRLIAKLLEPP-ILPVDYHPPELFQYR-SLSGYDHYGYMYKPHN------CAP---------GRK-YP-----T-LLF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVTNSFKG-I-RF-LRL----HTLA--SL----------------GYA-----V----------------------------------------VV------L-D---GR-GS--------------NH------RGLQFEGHLRGRMG-----------TVEIED--QVEG----------------------------------------------L-----------------------------Y--WLAEN---------------------------------------V-DH---I-------DLN--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMGLA-----Q--------------RP--------------D--VFKI----------------------------------------------A--IAG------------------------------------------A-----PVTCWTAY----------------DTGYTERYMGTP--SANVTG-----------------------------------------YADGSV---------------------------------------------------------------------------------------------------------------------------------------------------------L--RYA-----------------------------------------------SQFPDEE-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-H-----GLIDE--NVHF-YHTS-----------MLI-NS-L-----VKA-----------------CK---PYQLQ------------V-----Y--PN-------------E------------------------------------RHGIRQ-QDTCEHYETMVLSYLQ---------------------------------------------- 988
989 ------------------------------------------------------------------------------Y----V-------Y---------------------------------------------------------G--------------------GP--------------------------------GVQIITSGNTV-Q-RL-VRL----QNFI--QA----------------GYV-----V----------------------------------------VC------M-D---SR-GS--------------CG------RGIKFEKHIKNAMG-----------TIEIED--QVEG----------------------------------------------L-----------------------------Q--YLANK---------------------------------------L-NF---I-------DLS--------------------------------------------------------R----V-AI--Y-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LALMALA-----Q--------------QP--------------D--MFKI----------------------------------------------A--IAG------------------------------------------A-----PVTDWELY----------------DTGYTERYMSLP--EFNFLG-----------------------------------------YANGSV---------------------------------------------------------------------------------------------------------------------------------------------------------I--NFR-----------------------------------------------NRFPDQP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----GLNDE--NVHF-THTS-----------TLI-NS-L-----VGA-----------------SK---PYTLL------------V-----Y--PN-------------E------------------------------------RHGLRK-MDSREHFETSLLNFLQSHL------------------------------------------- 989
990 TQKELFKLMLPQ-TMSFPFVPPELFMYKNSTTGDDMYGLLFKPHN------IEP---------GKQ-YP-----A-VQF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVSNSFKG-V-RF-LRL----YTLA--SL----------------GYA-----V----------------------------------------VI------V-D---GR-GS--------------CR------RGLRFEGVLRNRLG-----------HVELDD--QVEG----------------------------------------------L-----------------------------H--WIAAK---------------------------------------S-GC---I-------DLN--------------------------------------------------------R----I-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMGLA-----K--------------RP--------------D--TYKV----------------------------------------------A--IAG------------------------------------------A-----PVTCWTVY----------------DTGYTERYLDTP--TNNPTG-----------------------------------------YVQSSV---------------------------------------------------------------------------------------------------------------------------------------------------------L--NLA-----------------------------------------------KNFPNEE-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-H-----GLIDE--NVHF-HHTS-----------LLI-DE-L-----VKH-----------------CK---PYHLQ------------I-----Y--PQ-------------E------------------------------------RHGIRR-LETSEHYETNILSWLQ---------------------------------------------- 990
991 ------------------------------------YGMIYKPHA------VQP---------GRK-HP-----T-VLF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNSFKG-I-KY-LRL----NTLA--SL----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CQ------RGLRFEGALKNQMG-----------QVEIED--QVEG----------------------------------------------L-----------------------------Q--FVAEK---------------------------------------Y-GF---I-------DLS--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSLMGLI-----H--------------KP--------------Q--VFKV----------------------------------------------A--IAG------------------------------------------A-----PVTVWMAY----------------DTGYTERYMDVP--ENNQLG-----------------------------------------YEAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--LHV-----------------------------------------------EKLPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GFLDE--NVHF-FHTN-----------FLV-SQ-L-----IRA-----------------GK---PYQLQ------------I-----Y--PN-------------E------------------------------------RHSIRC-PESGEHYEVTLLHFLQE--------------------------------------------- 991
992 ------------------------------------YGMIYKPHA------VQP---------GKK-HP-----T-VLF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNSFKG-I-KY-LRL----NTLA--SL----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CQ------RGLRFEGALKNQMG-----------QVEIED--QVEG----------------------------------------------L-----------------------------Q--FVAEK---------------------------------------Y-GF---I-------DLS--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSLMGLI-----H--------------KP--------------Q--VFKV----------------------------------------------A--IAG------------------------------------------A-----PVTVWMAY----------------DTGYTERYMDVP--ENNQLG-----------------------------------------YEAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--LHV-----------------------------------------------EKLPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GFLDE--NVHF-FHTN-----------FLV-SQ-L-----IRA-----------------GK---PYQLQ------------I-----Y--PN-------------E------------------------------------RHSIRC-PESGEHYEVTLLHFLQE--------------------------------------------- 992
993 ------------------------------------YGMIYKPHA------LQP---------GKK-HP-----T-VLF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNSFKG-I-KY-LRL----NTLA--SL----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CQ------RGLRFEGALKNQMG-----------QVEIED--QVEG----------------------------------------------L-----------------------------Q--FVAEK---------------------------------------Y-GF---I-------DLS--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSLMGLI-----H--------------KP--------------Q--VFKV----------------------------------------------A--IAG------------------------------------------A-----PVTVWMAY----------------DTGYTERYMDVP--ENNQHG-----------------------------------------YEAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--LHV-----------------------------------------------EKLPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GFLDE--NVHF-FHTN-----------FLV-SQ-L-----IRA-----------------GK---PYQLQ------------I-----Y--PN-------------E------------------------------------RHSIRC-PESGEHYEVTLLHFLQE--------------------------------------------- 993
994 --------MEAA-SCPPDYVPPEIFHFH-TRSDVRLYGMIYKPHA------VQP---------GRK-HP-----T-VLF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNSFKG-I-KY-LRL----NTLA--SL----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CQ------RGLRFEGALKNQMG-----------QVEIED--QVEG----------------------------------------------L-----------------------------Q--FVAEK---------------------------------------Y-GF---I-------DLS--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSLMGLI-----H--------------KP--------------Q--VFKV----------------------------------------------A--IAG------------------------------------------A-----PVTVWMAY----------------DTGYTERYMDVP--ENNQLG-----------------------------------------YEAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--LHV-----------------------------------------------EKLPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GFLDE--NVHF-FHTN-----------FLV-SQ-L-----IRA-----------------GK---PYQLQ------------I-----Y--PN-------------E------------------------------------RHSIRC-PESGEHYEVTLLHFLQEH-------------------------------------------- 994
995 QPRFWASMMEAA-SCPPDYVPPEIFHFH-TRSDVRLYGMIYKPHA------VQP---------GRK-HP-----T-VLF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNSFKG-I-KY-LRL----NTLA--SL----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CQ------RGLRFEGALKNQMG-----------QVEIED--QVEG----------------------------------------------L-----------------------------Q--FVAEK---------------------------------------Y-GF---I-------DLS--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSLMGLI-----H--------------KP--------------Q--VFKV----------------------------------------------A--IAG------------------------------------------A-----PVTVWMAY----------------DTGYTERYMDVP--ENNQLG-----------------------------------------YEAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--LHV-----------------------------------------------EKLPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GFLDE--NVHF-FHTN-----------FLV-SQ-L-----IRA-----------------GK---PYQLQ------------I-----Y--PN-------------E------------------------------------RHSIRC-PESGEHYEVTLLHFLQ---------------------------------------------- 995
996 QPRFWASMMEAA-SCPPDYVPPEIFHFH-TRSDVRLYGMIYKPHA------VQP---------GRK-HP-----T-VLF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNSFKG-I-KY-LRL----NTLA--SL----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CQ------RGLRFEGALKNQMG-----------QVEIED--QVEG----------------------------------------------L-----------------------------Q--FVAEK---------------------------------------Y-GF---I-------DLS--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSLMGLI-----H--------------KP--------------Q--VFKV----------------------------------------------A--IAG------------------------------------------A-----PVTVWMAY----------------DTGYTERYMDVP--ENNQLG-----------------------------------------YEAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--LHV-----------------------------------------------EKLPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GFLDE--NVHF-FHTN-----------FLV-SQ-L-----IRA-----------------GK---PYQLQ------------I-----Y--PN-------------E------------------------------------RHSIRC-PESGEHYEVTLLHFLQ---------------------------------------------- 996
997 QPRFWASMMEAA-SCPPDYVPPEIFHFH-TRSDVRLYGMIYKPHA------VQP---------GKK-HP-----T-VLF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNSFKG-I-KY-LRL----NTLA--SL----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CQ------RGLRFEGALKNQMG-----------QVEIED--QVEG----------------------------------------------L-----------------------------Q--FVAEK---------------------------------------Y-GF---I-------DLS--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSLMGLI-----H--------------KP--------------Q--VFKV----------------------------------------------A--IAG------------------------------------------A-----PVTVWMAY----------------DTGYTERYMDVP--ENNQLG-----------------------------------------YEAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--LHV-----------------------------------------------EKLPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GFLDE--NVHF-FHTN-----------FLV-SQ-L-----IRA-----------------GK---PYQLQ------------I-----Y--PN-------------E------------------------------------RHSIRC-PESGEHYEVTLLHFLQ---------------------------------------------- 997
998 QPRFWASMMEAA-SCPPDYVPPEIFHFH-TRSDVRLYGMIYKPHA------LQP---------GKK-HP-----T-VLF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNSFKG-I-KY-LRL----NTLA--SL----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CQ------RGLRFEGALKNQMG-----------QVEIED--QVEG----------------------------------------------L-----------------------------Q--FVAEK---------------------------------------Y-GF---I-------DLS--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSLMGLI-----H--------------KP--------------Q--VFKV----------------------------------------------A--IAG------------------------------------------A-----PVTVWMAY----------------DTGYTERYMDVP--ENNQHG-----------------------------------------YEAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--LHV-----------------------------------------------EKLPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GFLDE--NVHF-FHTN-----------FLV-SQ-L-----IRA-----------------GK---PYQLQ------------I-----Y--PN-------------E------------------------------------RHSIRC-PESGEHYEVTLLHFLQ---------------------------------------------- 998
999 ------------------------------------YGMIYKPHA------VQP---------GKK-HP-----T-VLF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNSFKG-I-KY-LRL----NTLA--SL----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CQ------RGLRFEGALKNQMG-----------QVEIED--QVEG----------------------------------------------L-----------------------------R--FVAEK---------------------------------------Y-GF---I-------DLS--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSLMGLI-----H--------------KP--------------Q--VFKV----------------------------------------------A--IAG------------------------------------------A-----PVTVWMAY----------------DTGYTERYMDVP--EKNQVG-----------------------------------------YEAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--LHV-----------------------------------------------EKLPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GFLDE--NVHF-FHTN-----------FLV-SQ-L-----IRA-----------------GK---PYQLQ------------I-----Y--PN-------------E------------------------------------RHSIRC-PESGEHYEVTLLHFLQE--------------------------------------------- 999
1000 -------MMEAA-SCPPDYVPPEIFHFH-TRADVRLYGMIYKPHA------VQP---------GKK-HP-----T-VLF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNSFKG-I-KY-LRL----NTLA--SL----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CQ------RGLRFEGALKNQMG-----------QVEIED--QVEG----------------------------------------------L-----------------------------R--FVAEK---------------------------------------Y-GF---I-------DLS--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSLMGLI-----H--------------KP--------------Q--VFKV----------------------------------------------A--IAG------------------------------------------A-----PVTVWMAY----------------DTGYTERYMDVP--EKNQVG-----------------------------------------YEAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--LHV-----------------------------------------------EKLPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GFLDE--NVHF-FHTN-----------FLV-SQ-L-----IRA-----------------GK---PYQLQ------------I-----Y--PN-------------E------------------------------------RHSIR----------------------------------------------------------------1000
1001 ------------------------------------YGMIYKPHA------VQP---------GKK-HP-----T-VLF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNSFKG-I-KY-LRL----NTLA--SL----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CQ------RGLRFEGALKNQMG-----------QVEIED--QVEG----------------------------------------------L-----------------------------Q--FVAEK---------------------------------------Y-GF---V-------DLS--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSLMGLI-----H--------------KP--------------Q--VFKV----------------------------------------------A--IAG------------------------------------------A-----PVTVWMAY----------------DTGYTERYMDVP--ENNQLG-----------------------------------------YEAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--LHV-----------------------------------------------EKLPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GFLDE--NVHF-FHTN-----------FLV-SQ-L-----IRA-----------------GK---PYQLQ------------I-----Y--PN-------------E------------------------------------RHSIRC-PESGEHYEVTLLHFLQE---------------------------------------------1001
1002 -------MMEAA-SCPPDYVPPEIFHFH-TRSDVRLYGMIYKPHA------VQP---------GKK-HP-----T-VLF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNSFKG-I-KY-LRL----NTLA--SL----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CQ------RGLRFEGALKNQMG-----------QVEIED--QVEG----------------------------------------------L-----------------------------Q--FVAEK---------------------------------------Y-GF---V-------DLS--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSLMGLI-----H--------------KP--------------Q--VFKV----------------------------------------------A--IAG------------------------------------------A-----PVTVWMAY----------------DTGYTERYMDVP--ENNQLG-----------------------------------------YEAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--LHV-----------------------------------------------EKLPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GFLDE--NVHF-FHTN-----------FLV-SQ-L-----IRA-----------------GK---PYQLQ------------I-----Y--PN-------------E------------------------------------RHSIRC-PESGEHYEVTLLHFLQE---------------------------------------------1002
1003 QPRFWASMMEAA-NCPPDYVPPEIFHFH-TRADVQLYGMIYKPHT------LQP---------GRK-HP-----T-VLF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNSFKG-I-KY-LRL----NTLA--SL----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CQ------RGLHFEGALKNQMG-----------QVEIED--QVEG----------------------------------------------L-----------------------------Q--YVAEK---------------------------------------Y-GF---I-------DLS--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSLMGLI-----H--------------KP--------------Q--VFKV----------------------------------------------A--IAG------------------------------------------A-----PVTVWMAY----------------DTGYTERYMDVP--ENNQQG-----------------------------------------YEAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--LHV-----------------------------------------------EKLPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GFLDE--NVHF-FHTN-----------FLV-SQ-L-----IRA-----------------GK---PYQLQ------------I-----Y--PN-------------E------------------------------------RHSIRC-RESGEHYEVTLLHFLQ----------------------------------------------1003
1004 ------------------------------------YGMVYKPHD------VQP---------GKK-HP-----T-VLF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNSFKG-I-KY-LRL----NTLA--SL----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CQ------RGLRFEGALKNQMG-----------QVEIED--QVEG----------------------------------------------L-----------------------------Y--YVAEK---------------------------------------Y-GF---I-------DLS--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSLMGLI-----C--------------KP--------------N--VFKI----------------------------------------------A--IAG------------------------------------------A-----PVTVWMAY----------------DTGYTERYMDIP--ENNQQG-----------------------------------------YEAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--LHV-----------------------------------------------EKLPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GFLDE--NVHF-FHTN-----------FLV-SQ-L-----IRA-----------------GK---PYQLQ------------I-----Y--PN-------------E------------------------------------RHSIRC-PESGEHYEITLLHFLQE---------------------------------------------1004
1005 QPKFWASMMEAA-SCPPDYVPPEIFHFR-TQSDVELYGMVYKPHD------VQP---------GKK-HP-----T-VLF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNSFKG-I-KY-LRL----NTLA--SL----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CQ------RGLRFEGALKNQMG-----------QVEIED--QVEG----------------------------------------------L-----------------------------Y--YVAEK---------------------------------------Y-GF---I-------DLS--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSLMGLI-----C--------------KP--------------N--VFKI----------------------------------------------A--IAG------------------------------------------A-----PVTVWMAY----------------DTGYTERYMDIP--ENNQQG-----------------------------------------YEAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--LHV-----------------------------------------------EKLPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GFLDE--NVHF-FHTN-----------FLV-SQ-L-----IRA-----------------GK---PYQLQ------------I-----Y--PN-------------E------------------------------------RHSIRC-PESGEHYEITLLHFLQ----------------------------------------------1005
1006 -----------T-GCRPDYIPPEIFSFP-ASSGFRLYGMLYKPHN------LKP---------GKK-HP-----T-ILF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNSYKG-V-KY-LRL----NTLA--SL----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CQ------RGLKFEGALKNKMG-----------QVEIED--QVEG----------------------------------------------L-----------------------------Q--FVAEK---------------------------------------Y-KF---I-------DLS--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSLMGLI-----H--------------RP--------------N--IFKV----------------------------------------------A--IAG------------------------------------------A-----PVTVWMAY----------------DTGYTERYMDVP--ENNQQG-----------------------------------------YEAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--LHV-----------------------------------------------DKLPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GFLDE--NVHF-FHTN-----------FLV-SQ-L-----IRA-----------------GK---PYQLQ------------I-----Y--PN-------------E------------------------------------RHSIRC-PESGEHYEIMLLYFLQQH--------------------------------------------1006
1007 EPEFWASMMEAT-GCRPDYIPPEIFSFP-ASSGFRLYGMLYKPHN------LKP---------GKK-HP-----T-ILF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNSYKG-V-KY-LRL----NTLA--SL----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CQ------RGLKFEGALKNKMG-----------QVEIED--QVEG----------------------------------------------L-----------------------------Q--FVAEK---------------------------------------Y-KF---I-------DLS--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSLMGLI-----H--------------RP--------------N--IFKV----------------------------------------------A--IAG------------------------------------------A-----PVTVWMAY----------------DTGYTERYMDVP--ENNQQG-----------------------------------------YEAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--LHV-----------------------------------------------DKLPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GFLDE--NVHF-FHTN-----------FLV-SQ-L-----IRA-----------------GK---PYQLQ------------I-----Y--PN-------------E------------------------------------RHSIRC-PESGEHYEIMLLYFLQ----------------------------------------------1007
1008 -----------------------------------------------------------------------------LF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNSYKG-V-KY-LRL----NTLA--SL----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CQ------RGLKFEGALKNKMG-----------QVEIED--QVEG----------------------------------------------L-----------------------------Q--FVAEK---------------------------------------Y-KF---I-------DLS--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSLMGLI-----H--------------RP--------------N--IFKV----------------------------------------------A--IAG------------------------------------------A-----PVTVWMAY----------------DTGYTERYMDVP--ENNQQG-----------------------------------------YEAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--LHV-----------------------------------------------DKLPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GFLDE--NVHF-FHTN-----------FLV-SQ-L-----IRA-----------------GK---PYQLQ------------I-----Y--PN-------------E------------------------------------RHSIRC-PESGEHYEIMLLYFLQQHL-------------------------------------------1008
1009 -------------------IPPEIFHFR-TQSDVELYGMVYKPHD------LQP---------GKK-HP-----T-VLF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNSFKG-I-KY-LRL----NTLA--SL----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CQ------RGLKFEGALKNQMG-----------QVEIED--QVEG----------------------------------------------L-----------------------------H--YVAEK---------------------------------------Y-GF---V-------DLA--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSLMGLI-----C--------------KP--------------H--VFKV----------------------------------------------A--IAG------------------------------------------A-----PVTVWMAY----------------DTGYTERYMDVP--ENNQQG-----------------------------------------YEAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--LHV-----------------------------------------------EKLPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GFLDE--NVHF-FHTN-----------FLI-SQ-L-----IRA-----------------GK---PYQLQ------------I-----Y--PN-------------E------------------------------------RHSIRC-PESGEHYEITLLHF------------------------------------------------1009
1010 -----------V-CCPADYIPPEIFHFR-TQSDVELYGMVYKPHD------LQP---------GKK-HP-----T-VLF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNSFKG-I-KY-LRL----NTLA--SL----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CQ------RGLKFEGALKNQMG-----------QVEIED--QVEG----------------------------------------------L-----------------------------H--YVAEK---------------------------------------Y-GF---V-------DLA--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSLMGLI-----C--------------KP--------------H--VFKV----------------------------------------------A--IAG------------------------------------------A-----PVTVWMAY----------------DTGYTERYMDVP--ENNQQG-----------------------------------------YEAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--LHV-----------------------------------------------EKLPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GFLDE--NVHF-FHTN-----------FLI-SQ-L-----IRA-----------------GK---PYQLQ------------I-----Y--PN-------------E------------------------------------RHSIRC-PESGEHYEITLLHFLQ----------------------------------------------1010
1011 QPRFWASMMEAA-SCPADYIPPEIFHFR-TQSDVELYGMVYKPHD------LQP---------GKK-HP-----T-VLF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNSFKG-I-KY-LRL----NTLA--SL----------------GYA-----V----------------------------------------VV------I-D---GR-GS--------------CQ------RGLKFEGALKNQMG-----------QVEIED--QVEG----------------------------------------------L-----------------------------H--YVAEK---------------------------------------Y-GF---V-------DLA--------------------------------------------------------R----V-AI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSLMGLI-----C--------------KP--------------H--VFKV----------------------------------------------A--IAG------------------------------------------A-----PVTVWMAY----------------DTGYTERYMDVP--ENNQQG-----------------------------------------YEAGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--LHV-----------------------------------------------EKLPNEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-H-----GFLDE--NVHF-FHTN-----------FLI-SQ-L-----IRA-----------------GK---PYQLQ------------I-----Y--PN-------------E------------------------------------RHSIRC-PESGEHYEITLLHFLQ----------------------------------------------1011
1012 ------------------------------------YGMLYKPHD------LQP---------GKK-YP-----T-VLF----I-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNRFKG-V-KY-FRL----NTLA--SL----------------GYV-----V----------------------------------------VV------I-D---NR-GS--------------CH------RGLKFEGAFKYKMG-----------QIEIDD--QVEG----------------------------------------------L-----------------------------Q--YLASR---------------------------------------Y-DF---I-------DLD--------------------------------------------------------R----V-GI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMALM-----Q--------------RS--------------D--IFRV----------------------------------------------A--IAG------------------------------------------A-----PVTLWIFY----------------DTGYTERYMGHP--DQNEQG-----------------------------------------YYLGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--MQA-----------------------------------------------EKFPSEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GFLDE--NVHF-AHTS-----------ILL-SF-L-----VRA-----------------GK---PYDLQ------------I-----Y--PQ-------------E------------------------------------RHSIRV-PESGEHYELHLLHYLQE---------------------------------------------1012
1013 ------------------------------------YGMLYKPHD------LQP---------GKK-YP-----T-VLF----I-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNRFKG-V-KY-FRL----NTLA--SL----------------GYV-----V----------------------------------------VV------I-D---NR-GS--------------CH------RGLKFEGAFKYKMG-----------QIEIDD--QVEG----------------------------------------------L-----------------------------Q--YLASR---------------------------------------Y-DF---I-------DLD--------------------------------------------------------R----V-GI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMALM-----Q--------------RS--------------D--IFRV----------------------------------------------A--IAG------------------------------------------A-----PVTLWIFY----------------DTGYTERYMGHP--DQNEQG-----------------------------------------YYLGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--MQA-----------------------------------------------EKFPSEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GFLDE--NVHF-AHTS-----------ILL-SF-L-----VRA-----------------GK---PYDLQ------------I-----Y--PQ-------------E------------------------------------RHSIRV-PESGEHYELHLLHYLQE---------------------------------------------1013
1014 ------------------------------------YGMLYKPHD------LQP---------GKK-YP-----T-VLF----I-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNRFKG-V-KY-FRL----NTLA--SL----------------GYV-----V----------------------------------------VV------I-D---NR-GS--------------CH------RGLKFEGAFKYKMG-----------QIEIDD--QVEG----------------------------------------------L-----------------------------Q--YLASQ---------------------------------------Y-DF---I-------DLD--------------------------------------------------------R----V-GI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMALM-----Q--------------RS--------------D--IFRV----------------------------------------------A--IAG------------------------------------------A-----PVTLWIFY----------------DTGYTERYMGHP--DQNEQG-----------------------------------------YYLGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--MQA-----------------------------------------------EKFPSEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GFLDE--NVHF-AHTS-----------ILL-SF-L-----VRA-----------------GK---PYDLQ------------I-----Y--PQ-------------E------------------------------------RHSIRV-PESGEHYELHLLHYLQE---------------------------------------------1014
1015 -------------------TPPEIFSFE-STTGFTLYGMLYKPHD------LQP---------GKK-YP-----T-VLF----I-------Y---------------------------------------------------------G--------------------GP--------------------------------Q------------------------------------------------------------------------------------------------------------------------------------------------------G-----------QIEIDD--QVEG----------------------------------------------L-----------------------------Q--YLASR---------------------------------------Y-DF---I-------DLD--------------------------------------------------------R----V-GI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMALM-----Q--------------RS--------------D--IFRV----------------------------------------------A--IAG------------------------------------------A-----PVTLWIFY----------------DTGYTERYMGHP--DQNEQG-----------------------------------------YYLGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--MQA-----------------------------------------------EKFPSEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GFLDE--NVHF-AHTS-----------ILL-SF-L-----VRA-----------------GK---PYDLQ------------I-----Y--PQ-------------E------------------------------------RHSIRV-PESGEHYELHLLHY------------------------------------------------1015
1016 TKEFWATLLDSA-GPLPDYTPPEIFSFE-STTGFTLYGMLYKPHD------LQP---------GKK-YP-----T-VLF----I-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNRFKG-V-KY-FRL----NTLA--SL----------------GYV-----V----------------------------------------VV------I-D---NR-GS--------------CH------RGLKFEGAFKYKMG-----------QIEIDD--QVEG----------------------------------------------L-----------------------------Q--YLASQ---------------------------------------Y-DF---I-------DLD--------------------------------------------------------R----V-GI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMALM-----Q--------------RS--------------D--IFRV----------------------------------------------A--IAG------------------------------------------A-----PVTLWIFY----------------DTGYTERYMGHP--DQNEQG-----------------------------------------YYLGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--MQA-----------------------------------------------EKFPSEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GFLDE--NVHF-AHTS-----------ILL-SF-L-----VRA-----------------GK---PYDLQ------------I-----Y--PQ-------------E------------------------------------RHSIRV-PESGEHYELHLLHYLQ----------------------------------------------1016
1017 ------------------------------------YGMLYKPHD------LQP---------GKK-YP-----T-VLF----I-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNRFKG-V-KY-FRL----NTLA--SL----------------GYV-----V----------------------------------------VV------I-D---NR-GS--------------CH------RGLKFEGAFKYKMG-----------QIEIDD--QVEG----------------------------------------------L-----------------------------Q--YLASR---------------------------------------Y-DF---I-------DLD--------------------------------------------------------R----V-GI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMALM-----Q--------------RS--------------D--IFRV----------------------------------------------A--IAG------------------------------------------A-----PVTLWIFY----------------DTGYTERYMGHP--DQNEQG-----------------------------------------YYLGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--MQA-----------------------------------------------EKFPSEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GFLDE--NVHF-AHTS-----------ILL-SF-L-----VRA-----------------GK---PYDLQ------------I-----Y--PQ-------------E------------------------------------RHSIRV-PESGEHYELHLLHYLQE---------------------------------------------1017
1018 ------------------------------------YGMLYKPHD------LQP---------GKK-YP-----T-VLF----I-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNRFKG-V-KY-FRL----NTLA--SL----------------GYV-----V----------------------------------------VV------I-D---NR-GS--------------CH------RGLKFEGAFKYKMG-----------QIEIDD--QVEG----------------------------------------------L-----------------------------Q--YLASR---------------------------------------Y-DF---I-------DLD--------------------------------------------------------R----V-GI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMALM-----Q--------------RS--------------D--IFRV----------------------------------------------A--IAG------------------------------------------A-----PVTLWIFY----------------DTGYTERYMGHP--DQNEQG-----------------------------------------YYLGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--MQA-----------------------------------------------EKFPSEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GFLDE--NVHF-AHTS-----------ILL-SF-L-----VRA-----------------GK---PYDLQ------------I-----Y--PQ-------------E------------------------------------RHSIRV-PESGEHYELHLLHYLQE---------------------------------------------1018
1019 ------------------------------------YGMLYKPHD------LQP---------GKK-YP-----T-VLF----I-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNRFKG-V-KY-FRL----NTLA--SL----------------GYV-----V----------------------------------------VV------I-D---NR-GS--------------CH------RGLKFEGAFKYKMG-----------QIEIDD--QVEG----------------------------------------------L-----------------------------Q--YLASR---------------------------------------Y-DF---I-------DLD--------------------------------------------------------R----V-GI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMALM-----Q--------------RS--------------D--IFRV----------------------------------------------A--IAG------------------------------------------A-----PVTLWIFY----------------DTGYTERYMGHP--DQNEQG-----------------------------------------YYLGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--MQA-----------------------------------------------EKFPSEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GFLDE--NVHF-AHTS-----------ILL-SF-L-----VRA-----------------GK---PYDLQ------------I-----Y--PQ-------------E------------------------------------RHSIRV-PESGEHYELHLLHYLQE---------------------------------------------1019
1020 TKEFWATILDSA-GPLPDYTPPEIFSFE-STTGFTLYGMLYKPHD------LQP---------GKK-YP-----T-VLF----I-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNRFKG-V-KY-FRL----NTLA--SL----------------GYV-----V----------------------------------------VV------I-D---NR-GS--------------CH------RGLKFEGAFKYKMG-----------QIEIDD--QVEG----------------------------------------------L-----------------------------Q--YLASQ---------------------------------------Y-DF---I-------DLD--------------------------------------------------------R----V-GI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMALM-----Q--------------RS--------------D--IFRV----------------------------------------------A--IAG------------------------------------------A-----PVTLWIFY----------------DTGYTERYMGHP--DQNEQG-----------------------------------------YYLGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--MQA-----------------------------------------------EKFPSEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GFLDE--NVHF-AHTS-----------ILL-SF-L-----VRA-----------------GK---PYDLQ------------I-----Y--PQ-------------E------------------------------------RHSIRV-PESG----------------------------------------------------------1020
1021 TKEFWATILDSA-GPLPDYTPPEIFSFE-STTGFTLYGMLYKPHD------LQP---------GKK-YP-----T-VLF----I-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNRFKG-V-KY-FRL----NTLA--SL----------------GYV-----V----------------------------------------VV------I-D---NR-GS--------------CH------RGLKFEGAFKYKMG-----------QIEIDD--QVEG----------------------------------------------L-----------------------------Q--YLASR---------------------------------------Y-DF---I-------DLD--------------------------------------------------------R----V-GI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMALM-----Q--------------RS--------------D--IFRV----------------------------------------------A--IAG------------------------------------------A-----PVTLWIFY----------------DTGYTERYMGHP--DQNEQG-----------------------------------------YYLGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--MQA-----------------------------------------------EKFPSEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GFLDE--NVHF-AHTS-----------ILL-SF-L-----VRA-----------------GK---PYDLQ------------I-----Y--PQ-------------E------------------------------------RHSIRV-PESGEHYELHLLHYLQ----------------------------------------------1021
1022 TKEFWATILDSA-GPLPDYTPPEIFSFE-STTGFTLYGMLYKPHD------LQP---------GKK-YP-----T-VLF----I-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNRFKG-V-KY-FRL----NTLA--SL----------------GYV-----V----------------------------------------VV------I-D---NR-GS--------------CH------RGLKFEGAFKYKMG-----------QIEIDD--QVEG----------------------------------------------L-----------------------------Q--YLASQ---------------------------------------Y-DF---I-------DLD--------------------------------------------------------R----V-GI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMALM-----Q--------------RS--------------D--IFRV----------------------------------------------A--IAG------------------------------------------A-----PVTLWIFY----------------DTGYTERYMGHP--DQNEQG-----------------------------------------YYLGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--MQA-----------------------------------------------EKFPSEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GFLDE--NVHF-AHTS-----------ILL-SF-L-----VRA-----------------GK---PYDLQ------------I-----Y--PQ-------------E------------------------------------RHSIRV-PESGEHYELHLLHYLQ----------------------------------------------1022
1023 ------------------------------------YGMLYKPHD------LQP---------GKK-YP-----T-VLF----I-------Y---------------------------------------------------------G--------------------GPQEAQFPGARLAVDPPLTLCMLPRNSTQDAPLFQVQLVNNRFKG-V-KY-FRL----NTLA--SL----------------GYV-----V----------------------------------------VV------I-D---NR-GS--------------CH------RGLKFEGAFKYKMG-----------QIEIDD--QVEG----------------------------------------------L-----------------------------Q--YLASQ---------------------------------------Y-DF---I-------DLD--------------------------------------------------------R----V-GI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMALM-----Q--------------RS--------------D--IFRV----------------------------------------------A--IAG------------------------------------------A-----PVTLWIFY----------------DTGYTERYMGHP--DQNEQG-----------------------------------------YYLGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--MQA-----------------------------------------------EKFPSEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GFLDE--NVHF-AHTS-----------ILL-SF-L-----VRA-----------------GK---PYDLQ------------I-----Y--PQ-------------E------------------------------------RHSIRV-PESGEHYELHLLHYLQ----------------------------------------------1023
1024 ------------------------------------YGMLYKPHD------LQP---------GKK-YP-----T-VLF----I-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNRFKG-V-KY-FRL----NTLA--SL----------------GYV-----V----------------------------------------VV------I-D---NR-GS--------------CH------RGLKFEGAFKYKMG-----------QIEIDD--QVEG----------------------------------------------L-----------------------------Q--YLASR---------------------------------------Y-DF---I-------DLD--------------------------------------------------------R----V-GI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMALM-----Q--------------RS--------------D--IFRV----------------------------------------------A--IAG------------------------------------------A-----PVTLWIFY----------------DTGYTERYMGHP--DQNEQG-----------------------------------------YYLGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--MQA-----------------------------------------------EKFPSEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GFLDE--NVHF-AHTS-----------ILL-SF-L-----VRA-----------------GK---PYDLQ------------I-----Y--PQ-------------E------------------------------------RHSIRV-PESGEHYELHLLHYLQ----------------------------------------------1024
1025 -----------------------------------------------------------------------------LF----I-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNRFKG-V-KY-FRL----NTLA--SL----------------GYV-----V----------------------------------------VV------I-D---NR-GS--------------CH------RGLKFEGAFKYKMG-----------QIEIDD--QVEG----------------------------------------------L-----------------------------Q--YLASR---------------------------------------Y-DF---T-------DLD--------------------------------------------------------R----V-GI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMALM-----Q--------------RS--------------D--IFRV----------------------------------------------A--IAG------------------------------------------A-----PVTLWIFY----------------DTGYTERYMGHP--DQNEQG-----------------------------------------YYLGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--MQA-----------------------------------------------EKFPSEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GFLDE--NVHF-AHTS-----------ILL-SF-L-----VRA-----------------GK---PYDLQ------------I-----Y--PQ-------------E------------------------------------RHSIRV-PESGEHYELHLLHYLQENL-------------------------------------------1025
1026 TKEFWATILDSA-GPLPDYIPPEVFSFE-SSTGFTLYGMMYKPHN------LQP---------GKK-YP-----T-VIF----I-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNRFKG-L-KY-FRL----NTLA--SL----------------GYV-----V----------------------------------------VV------I-D---NR-GS--------------CH------RGLKFEGAFKYKMG-----------QIEIDD--QVEG----------------------------------------------L-----------------------------H--YLASQ---------------------------------------Y-DF---I-------DLD--------------------------------------------------------R----V-GI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMALM-----Q--------------RS--------------D--IFRV----------------------------------------------A--IAG------------------------------------------A-----PVTLWIFY----------------DTGYTERYMGHP--EHNEQG-----------------------------------------YYLGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--MQA-----------------------------------------------EKFPSEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GFLDE--NVHF-AHTS-----------ILL-SF-L-----VRA-----------------GK---PYDLQ------------I-----Y--PQ-------------E------------------------------------RHSIRV---------------------------------------------------------------1026
1027 -------------------IPPEVFSFE-SSTGFTLYGMMYKPHN------LQP---------GKK-YP-----T-VIF----I-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNRFKG-L-KY-FRL----NTLA--SL----------------GYV-----V----------------------------------------VV------I-D---NR-GS--------------CH------RGLKFEGAFKYKMG-----------QIEIDD--QVEG----------------------------------------------L-----------------------------H--YLASQ---------------------------------------Y-DF---I-------DLD--------------------------------------------------------R----V-GI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMALM-----Q--------------RS--------------D--IFRV----------------------------------------------A--IAG------------------------------------------A-----PVTLWIFY----------------DTGYTERYMGHP--EHNEQG-----------------------------------------YYLGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--MQA-----------------------------------------------EKFPSEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GFLDE--NVHF-AHTS-----------ILL-SF-L-----VRA-----------------GK---PYDLQ------------I-----Y--PQ-------------E------------------------------------RHSIRV-PESGEHYELHLL--------------------------------------------------1027
1028 TKEFWATILDSA-GPLPDYIPPEVFSFE-SSTGFTLYGMMYKPHN------LQP---------GKK-YP-----T-VIF----I-------Y---------------------------------------------------------G--------------------GP--------------------------------QVQLVNNRFKG-L-KY-FRL----NTLA--SL----------------GYV-----V----------------------------------------VV------I-D---NR-GS--------------CH------RGLKFEGAFKYKMG-----------QIEIDD--QVEG----------------------------------------------L-----------------------------H--YLASQ---------------------------------------Y-DF---I-------DLD--------------------------------------------------------R----V-GI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSLMALM-----Q--------------RS--------------D--IFRV----------------------------------------------A--IAG------------------------------------------A-----PVTLWIFY----------------DTGYTERYMGHP--EHNEQG-----------------------------------------YYLGSV---------------------------------------------------------------------------------------------------------------------------------------------------------A--MQA-----------------------------------------------EKFPSEP-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GFLDE--NVHF-AHTS-----------ILL-SF-L-----VRA-----------------GK---PYDLQ------------I-----Y--PQ-------------E------------------------------------RHSIRV-PESGEHYELHLLYYLQ----------------------------------------------1028
1029 ISLHSVGWVEAPRDVLPTSRLPELFRYK-NAQGYDIYGMLFKPVN------CTE---------GEK-YP-----T-MLY----V-------Y---------------------------------------------------------G--------------------GP--------------------------------GVQLVSNSQRS-V-RR-LNL----YALP--SF----------------GYA-----V----------------------------------------VM------L-D---TM-GS--------------CN------RGIRFEAAIQNCMG-----------QIEIEQ--QIEG----------------------------------------------L-----------------------------K--LIAEK---------------------------------------S-GI---I-------DMN--------------------------------------------------------R----I-VI--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LALMGLA-----Q--------------RP--------------D--IFKV----------------------------------------------A--IAG------------------------------------------A-----PVTCWQLY----------------DTGYTERYMKSP--AENKNA-----------------------------------------YQDSSV---------------------------------------------------------------------------------------------------------------------------------------------------------L--KFA-----------------------------------------------SQFPNEP-N--------------------------R-------------------------LM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-H-----GLMDE--NVHF-SHTK-----------ALI-SE-L-----IKE-----------------GK---PYQLQ------------V-----Y--PN-------------E------------------------------------RHGIRN-AAAAKHYETNVVWFLQ----------------------------------------------1029
1030 ------------------------------------FGMIIRPAN------FDG---------SKK-YP-----V-FHY----V-------Y---------------------------------------------------------G--------------------GP--------------------------------GIQIVHNDYSW-V-QF-IR-------FA--RL----------------GYV-----V----------------------------------------VV------L-D---NR-GS--------------AH------RGIDFEGFIAGKMG-----------TAEVED--QVEG----------------------------------------------L-----------------------------Q--IIAER---------------------------------------TGGF---M-------DLK--------------------------------------------------------R----V-VV--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MALQMIA-----K--------------HP--------------Q--QYIA----------------------------------------------A--IAG------------------------------------------G-----AVTDWRLY----------------DTAYTERYLGFP--VVADI------------------------------------------YQKSSI---------------------------------------------------------------------------------------------------------------------------------------------------------I--PLV-----------------------------------------------DKLPDEP-N--------------------------R-------------------------LM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----GLMDE--NVHF-SHAT-----------TLI-DE-C-----IKK-----------------GK---WHELL------------V-----F--PR-------------E------------------------------------RHGIRN-TDASVYLDARMMFFAQQ---------------------------------------------1030
1031 ------------------------------------YAMILRPSN------FDP---------YKK-YP-----V-FHY----V-------Y---------------------------------------------------------G--------------------GP--------------------------------GIQIVHNDFSW-I-QY-IR-------FC--RL----------------GYV-----V----------------------------------------VF------I-D---NR-GS--------------AH------RGIEFERHIHKKMG-----------TVEVED--QVEG----------------------------------------------L-----------------------------Q--MLAER---------------------------------------TGGF---M-------DMS--------------------------------------------------------R----V-VV--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MALQMIA-----K--------------HP--------------N--IYRA----------------------------------------------A--IAG------------------------------------------G-----AVSDWRLY----------------DTAYTERYMGYP--LEEHV------------------------------------------YGASSI---------------------------------------------------------------------------------------------------------------------------------------------------------T--GLV-----------------------------------------------EKLPDEP-N--------------------------R-------------------------LM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----GLMDE--NVHF-AHLT-----------HLV-DE-C-----IKK-----------------GK---WHELV------------I-----F--PN-------------E------------------------------------RHGVRN-NDASIYLDARMMYFAQQ---------------------------------------------1031
1032 ----------DNDKKKININIPKIFNFK-NSKGVTIYGQYTLPSD------YSK---------DKK-YP-----T-VVY----V-------Y---------------------------------------------------------G--------------------GP--------------------------------HVQIVRNQY-----NY-IKQ----H-YT--NF----------------GFI-----Q----------------------------------------VM------I-D---NV-GS--------------AN------RGLEFESHIREKMG-----------QVEIGD--QVEG----------------------------------------------I-----------------------------N--YLVGN---------------------------------------DIVS---I-------DVN--------------------------------------------------------R----I-AI--S-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-NSLMAIS-----Q--------------RP--------------D--VFKI----------------------------------------------A--VCG------------------------------------------A-----PVSDWRLY----------------NTGYTERYMNVP--QDNIDG-----------------------------------------YKLGDT---------------------------------------------------------------------------------------------------------------------------------------------------------T--HY-------------------------------------------------SFPTEE-N--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GLQDE--NVHF-SNTI-----------YII-DH-L-----TKT-----------------QK---PYILK------------T-----L--PN-------------E------------------------------------RHGVR----------------------------------------------------------------1032
1033 ------------------LPPPEVISFETRDREANLFAAVYRPDVN-----VHG---------PGP-YP-----T-IVA----V-------Y---------------------------------------------------------G--------------------GP--------------------------------HVQWVSRSWGC-T-VD-MRA----QRLR--DL----------------GFL-----V----------------------------------------LK------C-D---NR-GS--------------FR------RGLAFEAWVKWRMG-----------GVEITD--QEDC----------------------------------------------V-----------------------------H--WAVKK-----------------------------------------GL---A-------DPA--------------------------------------------------------R----V-GI--Y-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-ATAMCLC-----K--------------AP--------------N--TFRV----------------------------------------------G--VSG------------------------------------------A-----PVTAWDGY----------------DTHYTERYMGTP--MENPKG-----------------------------------------YTESSV---------------------------------------------------------------------------------------------------------------------------------------------------------L--THA-----------------------------------------------SKL--E--G--------------------------K-------------------------LM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----GLMDE--NVHF-RHTA-----------RLI-NA-L-----IAA-----------------RK---PYDLL------------I-----F--PD-------------E------------------------------------RHSPR----------------------------------------------------------------1033
1034 ---------------LANLPAPELLKFPTSDGSEMLHAALYRPDAR-----IHG---------PGP-YP-----L-ICA----V-------Y---------------------------------------------------------G--------------------GP--------------------------------HVQRVNRSWSQ-C-AD-MRA----QRLR--SL----------------GFC-----V----------------------------------------VK------C-D---NR-GS--------------SR------RGLAFESAISRRLG-----------RLEVLD--QVAA----------------------------------------------V-----------------------------R--QLAAR-----------------------------------------GV---A-------DPN--------------------------------------------------------R----V-GI--Y-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSAMCLC-----R--------------AP--------------D--VFHA----------------------------------------------A--VAG------------------------------------------A-----PVTSWDGY----------------DTHYTERYMGLP--SDNPAG-----------------------------------------YRESAL---------------------------------------------------------------------------------------------------------------------------------------------------------F--EHI-----------------------------------------------PNM--S--G--------------------------S-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MI-H-----GLIDE--NVHF-RHTA-----------RLI-NK-L-----VAS-----------------GK---SYELC------------I-----F--PD-------------E------------------------------------RHSPRR-LRDRIYMEQRIGDFFV----------------------------------------------1034
1035 ----------------LSLVTPTFVEFPSSDDKVTLQAAYLRPDQD-----KFG---------PGP-YP-----T-VVA----V-------Y---------------------------------------------------------G--------------------GP--------------------------------HVQTVSNSWTV-T-AD-LRS----QFLC--SQ----------------GYL-----V----------------------------------------IK------V-D---NR-GS--------------SR------RGLHFESQVKWNMG-----------YLEVED--QKAG----------------------------------------------V-----------------------------N--FFVER-----------------------------------------GL---A-------DKH--------------------------------------------------------R----V-AI--Y-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MSAMALA-----R--------------AP--------------E--TFHV----------------------------------------------G--IAG------------------------------------------A-----PVTHWDGY----------------DTHYTERYMGRP--QDNPEG-----------------------------------------YAQSSV---------------------------------------------------------------------------------------------------------------------------------------------------------M--THV-----------------------------------------------DQI--E--G--------------------------S-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----GLIDE--NVHF-RHTA-----------RLI-NA-L-----IRA-----------------QK---HYELL------------L-----F--PD-------------E------------------------------------RHSPRS-LKDRVFMEQRIHSFIQ----------------------------------------------1035
1036 LTTEQEDLRVSILQAQAKLSVPKIISFPTRDGKETLYGAVYLPDRD-----IHG---------DGP-YP-----T-MVS----V-------Y---------------------------------------------------------G--------------------GP--------------------------------HVQRVARMWAM-T-VD-MRA----QRFR--DM----------------GYA-----V----------------------------------------LK------V-D---NR-GS--------------FR------RGSAFEGAIKHCMG-----------TVEILD--QEDG----------------------------------------------V-----------------------------R--KLVEE-----------------------------------------GV---T-------IEG--------------------------------------------------------R----V-GI--Y-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MSAISLM-----K--------------VP--------------E--TFKL----------------------------------------------A--IAG------------------------------------------A-----PVTSWDGY----------------DTCYTERYMSTP--QLNPTG-----------------------------------------YREGSV---------------------------------------------------------------------------------------------------------------------------------------------------------M--EAV-----------------------------------------------GNMQKG--Q--------------------------K-------------------------LM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----GLIDE--NVHF-RHTA-----------RLI-SA-L-----INA-----------------RK---HYDLL------------L-----F--PG-------------E------------------------------------RHSPRH-LEDRIYMEQRIAE-------------------------------------------------1036
1037 -------------LKKFQQLSPEMVQFSGKDG-TSFYGTLYLPDEN-----KYG---------PPP-YK-----T-LIN----V-------Y---------------------------------------------------------G--------------------GP--------------------------------SVQLVSDSWIS-T-VD-MRA----QYLR--SK----------------GIL-----V----------------------------------------WK------M-D---NR-GS--------------AR------RGLHFEGQLKYNIG-----------RVDAED--QLAG----------------------------------------------A-----------------------------E--WLIEQ-----------------------------------------GL---A-------KAG--------------------------------------------------------H----I-GL--Y-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSAMCLA-----R--------------FP--------------D--TFCC----------------------------------------------A--VSG------------------------------------------A-----PVTAWDGY----------------DTFYTEKYMGLP--SEHRDA-----------------------------------------YEYGSI---------------------------------------------------------------------------------------------------------------------------------------------------------M--HHV-----------------------------------------------NNL--R--G--------------------------K-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GMIDE--NVHF-RHTA-----------RLI-NS-L-----MAE-----------------RK---PYEIL------------L-----F--PD-------------E------------------------------------RHMPRQ-LDDRIYMEERIWDFVER---------------------------------------------1037
1038 ------------ILKSLKLEPPEFVQIQANDGKTTLYGAVYKPDSS-----KFG---------PPP-YK-----T-MIN----V-------Y---------------------------------------------------------G--------------------GP--------------------------------SVQLVYDSWIN-T-VD-MRT----QYLR--SR----------------GIL-----V----------------------------------------WK------L-D---NR-GT--------------AR------RGLKFESWMKHNCG-----------YVDAED--QVTG----------------------------------------------A-----------------------------K--WLIEQ-----------------------------------------GL---A-------KPD--------------------------------------------------------H----I-GV--Y-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LSATLLT-----R--------------YP--------------E--IFNC----------------------------------------------A--VSG------------------------------------------A-----PVTSWDGY----------------DSFYTEKYMGLP--TE-EER-----------------------------------------YLKSSV---------------------------------------------------------------------------------------------------------------------------------------------------------M--HHV-----------------------------------------------GNLTDK--Q--------------------------K-------------------------LM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----GMIDE--NVHF-RHTA-----------RLV-NA-L-----VEA-----------------GK---RYELL------------I-----F--PD-------------E------------------------------------RHMPRK-KKDRIYMEQRIWEFIEK---------------------------------------------1038
1039 FGSQLLFHLSDSVELPLDFNPPISFTAT-ASSGETLHGVVYRPTK------YQE---------GKR-YP-----T-VLY----V-------Y---------------------------------------------------------G--------------------GP--------------------------------EFQVVKNDFSR-F--L-MKV----NQWT--TC----------------GFS-----V----------------------------------------VM------I-D---NR-GS--------------SN------RGKKFESHIQYQMG-----------SVEIED--QVVG----------------------------------------------L-----------------------------A--AAVKA---------------------------------------A-PC---V-------DAE--------------------------------------------------------R----V-AI--L-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MALHGIA-----K--------------RP--------------D--IFKV----------------------------------------------A--VSG------------------------------------------A-----PVTDYRWY----------------DTGYTERYLGVP--PLSDRA-----------------------------------------YEVSSV---------------------------------------------------------------------------------------------------------------------------------------------------------V--NLA-----------------------------------------------SKFPDKP-G--------------------------K-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-H-----GMNDE--NVLY-THTS-----------LLI-DA-L-----IRA-----------------GK---PYQIQ------------M-----Y--NG-------------E------------------------------------RHGIRN-PTSALHCDAAILQFL-----------------------------------------------1039
1040 ICSTSSWGLSYLHRSPSSIFKHKFCEFESTTSKQRHFALALWPCEE-----IES---------SKK-FP-----I-IHS----V-------Y---------------------------------------------------------G--------------------GP--------------------------------SIQIVRNSWHS-ISQF-LK-------FL--AY----------------GYA-----V----------------------------------------VI------V-D---GR-GS--------------AN------RGVSFEGHIKEAMG-----------SVEMED--QVEG----------------------------------------------L-----------------------------K--QAIDQ---------------------------------------TGNI---L-------DGE--------------------------------------------------------R----V-VC--I-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MSIQLIA-----E--------------YP--------------N--VYKA----------------------------------------------A--VVG------------------------------------------G-----AVTDWQLY----------------DTAYTER--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-G--------------------------R-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-H-----GMIDE--NVHF-QHTI-----------LLI-NS-L-----IKA-----------------SK---PHQLL------------L-----F--PT-------------E------------------------------------RHAIR----------------------------------------------------------------1040
1041 ---------------------------------------VLMPSD------YPDDT-------SRR-LP-----V-LLD----S-------Y---------------------------------------------------------G--------------------GP--------------------------------HGARVVAAHNA-H----LTS----QWFA--DQ----------------GFA-----V----------------------------------------VV------A-D---GR-GT--------------PG------RSPAWEKAIHHDF------------TATLDD--QIEA----------------------------------------------L-----------------------------H--DLATR---------------------------------------Y--P---L-------DLD--------------------------------------------------------R----V-AI--R-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LAALAVL-----R--------------RP--------------D--VFHA----------------------------------------------G--IAG------------------------------------------A-----PVTDWRLY----------------DTHYTERYLGDP--AAHPET-----------------------------------------YARNSL---------------------------------------------------------------------------------------------------------------------------------------------------------VTDEGL-----------------------------------------------SAPAEPH-R--------------------------P-------------------------LM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-H-----GLADD--NVVV-AHAL-----------RLS-SA-L-----LAA-----------------GR---PHEVL------------P-----L--SG-------------V------------------------------------THMTPQ-EQVAENLLLLQVDFLRRSLG------------------------------------------1041
1042 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLTSAGYA-----V----------------------------------------LC------P-N---IR-PSGSG---------------------GGGGGIN-----------------ERYAD--VLMI----------------------------------------------L-----------------------------K--KAVSE-NLV--------------------------------------------------DES--------------------------------------------------------R----V-TI--S-G--WS-----------------DG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LSSLAVI-----R--------------NE-------------FDFRAVVCGGGVPDWSLVDANSN-PL---------------------WPRLDAED--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDDGYVSGEDQSKGGIEKSTP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GREDD--QVPV--SGPLAFWRQ--RQ-RWNGPVQM-----------------------------------------------------------------------VLYPK-------------------------------EKHVIRDRKHLLDLWTRVLGFYEK----------------------------------------------1042
1043 --------VAKHDLPQTSYLSAFTTDDA-----EIHYVEI-KPRH------MNP---------KKK-YP-----L-LVS----V-------Y---------------------------------------------------------G--------------------GP--------------------------------GSRTFNTKFDV-M----LDQ----CISS--GL----------------DAI-----V----------------------------------------LQ------I-E---PR-GT--------------GG------KGWNFRSWARQNIG-----------HWEPRDITAVT-----------------------------------------------R-----------------------------K--YISQH---------------------------------------A-KN---V-------DTE--------------------------------------------------------H----V-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-TTLKTLE-----Y--------------DQ--------------GQ-TFKY----------------------------------------------G--ISV------------------------------------------A-----PVTDWRLY----------------DAVYTERYMGTP--KPTNDA-----------------------------------------YGEYAL---------------------------------------------------------------------------------------------------------------------------------------------------------I--KNI-----------------------------------------------DAFSKVK----------------------------R-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LL-H-----GTADD--NVHI-ENTY-----------KLL-DS-F-----NVH-----------------NV--RNYDSH------------I-----F--PD-------------S------------------------------------NHALTF-HNAGPILYRQIYHWL-ENAFS-----------------------------------------1043
1044 --------IKNYDLPITSYKTMVLDDGV-----EINYIEI-KPAN------LNP---------KKK-YP-----I-LVN----I-------Y---------------------------------------------------------G--------------------GP--------------------------------GSQTFTTKSSL-A----FEQ----AVVS--GL----------------DVI-----V----------------------------------------LQ------I-E---PR-GT--------------GG------KGWSFRSWAREKLG-----------YWEPRDITEVT-----------------------------------------------K-----------------------------K--FIQRN---------------------------------------S-QH---I-------DES--------------------------------------------------------K----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-TSLKTVE-----L--------------DN--------------GD-TFKY----------------------------------------------A--MAV------------------------------------------A-----PVTNWTLY----------------DSVYTERYMNQP--SENHEG-----------------------------------------YFEVST---------------------------------------------------------------------------------------------------------------------------------------------------------I--QNF-----------------------------------------------KSFESLK----------------------------R-------------------------LF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-H-----GTFDD--NVHI-QNTF-----------RLV-DQ-L-----NLL-----------------GL--TNYDMH------------I-----F--PD-------------S------------------------------------DHSIRY-HNAQRIVFQKLYYWL-RDAFA-----------------------------------------1044
1045 --------LKEINLPTVRYKEVTIGKKE--DQVTLNIMEI-LPPN------FKA-K-------NQK-YP-----L-FVY----T-------Y---------------------------------------------------------G--------------------GP--------------------------------GSQTVMKKFDI-G----FLQ----IVSA--RL----------------NSI-----I----------------------------------------LV------I-D---PR-GT--------------GG------KGWKFESFAKNNIG-----------YWESRDLKTITS----------------------------------------------E-----------------------------Y--IKKN----------------------------------------K-KL---I-------DKE--------------------------------------------------------R----V-AL--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-VTLKTLE-----Y--------------DK--------------GE-VFKY----------------------------------------------G--MAV------------------------------------------A-----PVTNWLFY----------------DSIYTERYMGLP--DTDPNY-----------------------------------------ETSARI---------------------------------------------------------------------------------------------------------------------------------------------------------N--D-F-----------------------------------------------DNFKS--VK--------------------------R-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----GTGDD--NVHV-QNLM-----------WLL-DQ-L-----NIH-----------------NV--ENYDMH------------L-----F--PD-------------S------------------------------------DHSISY-DNAGVIVYDKLYSWL-QNAF------------------------------------------1045
1046 ----------------------------------------------------DK---------HQA-IP-----L-IVH----V-------Y---------------------------------------------------------G--------------------GP--------------------------------NDQNTKEATQI-G----IEE----VVAS--AS----------------QAA-----I----------------------------------------LR------I-D---GR-GS--------------GG------RGWKYRSAIYGQLG-----------TVEVED--QIKA----------------------------------------------I-----------------------------K--VVLRL---------------------------------------YRHL---L-------DAR--------------------------------------------------------R----V-AV--F-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MTLSMVN-----E--------------AP-------------EQ--FFKC----------------------------------------------A--VSV------------------------------------------A-----PVTNFAYY----------------DATYTERYMGDA--P--LES-----------------------------------------Y--SDV---------------------------------------------------------------------------------------------------------------------------------------------------------T--KKL-----------------------------------------------DNFKSTR------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-H-----GLLDD--NVHF-QNSA-----------ILI-DE-L-----QNR-----------------GV---DFDLM------------V-----Y--PN-------------Q------------------------------------AHSL---SSRTSHVVGKMTHFL-RQCF------------------------------------------1046
1047 ----------------------------------------------------DK---------HQA-IP-----L-IVH----V-------Y---------------------------------------------------------G--------------------GP--------------------------------NDQNTKEATQI-G----IEE----VVAS--AS----------------QAA-----I----------------------------------------LR------I-D---GR-GS--------------GG------RGWKYRSAIYGQLG-----------TVEVED--QIKA----------------------------------------------I-----------------------------K--VVLRL---------------------------------------YRHL---L-------DAR--------------------------------------------------------R----V-AV--F-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MTLSMVN-----E--------------AP-------------EQ--FFKC----------------------------------------------A--VSV------------------------------------------A-----PVTNFAYY----------------DATYTERYMGDA--P--LES-----------------------------------------Y--SDV---------------------------------------------------------------------------------------------------------------------------------------------------------T--KKL-----------------------------------------------DNFKSTR------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-H-----GLLDD--NVHF-QNSA-----------ILI-DE-L-----QNR-----------------GV---DFDLM------------V-----Y--PN-------------Q------------------------------------AHSL---SSRTSHVVGKMTHFL-RQCF------------------------------------------1047
1048 ----------------------------------------------------EK---------TRA-IP-----L-LVH----V-------Y---------------------------------------------------------G--------------------GP--------------------------------NDQNTKDASQI-G----IEE----IVAS--GQ----------------QVA-----I----------------------------------------LR------I-D---GR-GS--------------GG------RGWKYRSAVYGQLG-----------TVEVDD--QLNV----------------------------------------------I-----------------------------K--TVLRV---------------------------------------YKHL---L-------DSN--------------------------------------------------------R----V-AV--F-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MTLSMVN-----E--------------AA-------------EN--MFKC----------------------------------------------A--ISV------------------------------------------A-----PVTNFAYY----------------DATYTERYMGDA--P--LEA-----------------------------------------Y--SDV---------------------------------------------------------------------------------------------------------------------------------------------------------T--KKL-----------------------------------------------DNFKTTR------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-H-----GLLDD--NVHF-QNSA-----------ILI-EE-L-----QNR-----------------GI---DFDLM------------V-----Y--PN-------------Q------------------------------------AHSL---SSRTAHVVGKMSQFL-KQCF------------------------------------------1048
1049 -------------------------------------YMLQKPAN------LQE---------TAK-VP-----L-LVD----I-------Y---------------------------------------------------------G--------------------GP--------------------------------DSKNVYQRTPT-A----HAI----QIVS--QY----------------DIA-----Y----------------------------------------AR------I-D---VR-GT--------------GG------RGWNVKEQVYKNLG-----------EAETTD--TLDM----------------------------------------------I-----------------------------R--EFVRN---------------------------------------F-NF---I-------DED--------------------------------------------------------R----I-II--M-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTAKIAA-----K--------------DQ-------------GE--LIKC----------------------------------------------A--ISI------------------------------------------A-----PVTDFKYYGMFHTLYFKTFTFEFADSAYTERYLGQP--SDNPNG-----------------------------------------YKNTNV---------------------------------------------------------------------------------------------------------------------------------------------------------I--PHA-----------------------------------------------RNLSNTK------------------------------------------------------YF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LA-H-----GERDD--NVHY-QNSA-----------RWS-EA-L-----QYN-----------------GI---HFTQLVIMEITFSIRKIV-----Y--AN-------------E------------------------------------AHSL---SRKMH---------------------------------------------------------1049
1050 -------------------------------------YMMLTPAN------LLD---------GAK-IP-----L-LLD----I-------Y---------------------------------------------------------G--------------------GP--------------------------------DSKQVFQKTPT-A----HAI----QIVS--QY----------------DIA-----Y----------------------------------------AR------I-D---VR-GT--------------GG------RGWDVKEAVYRKLG-----------DAEVVD--TLDM----------------------------------------------I-----------------------------R--AFINT---------------------------------------F-GF---I-------DED--------------------------------------------------------R----I-AV--M-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTSKIAI-----K--------------DQ-------------GE--LVKC----------------------------------------------A--ISI------------------------------------------A-----PVTDFKYY----------------DSAYTERYLGQP--AENLQG-----------------------------------------YINTNV---------------------------------------------------------------------------------------------------------------------------------------------------------I--PHA-----------------------------------------------RNVTNVK------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LA-H-----GERDD--NVHY-QNSA-----------RWS-EA-L-----QQN-----------------GI---HFTQL------------V-----Y--AN-------------E------------------------------------AHSL---SHKLFHLYGEVQRFLMNDCF------------------------------------------1050
1051 -------LTTELLMPTKKRGTLKIAGFD------LWYQMM-FPPN------FDS---------SKK-YP-----L-LID----V-------Y---------------------------------------------------------G--------------------GP--------------------------------ASQNIDYVFRL-E----WAT----YLCS--TE----------------RII-----V----------------------------------------AS------F-D---GR-GS--------------GF------QGDEIMHAIYERLG-----------TYEVED--QITA----------------------------------------------V-----------------------------R--KFIE----------------------------------------M-GF---I-------DKD--------------------------------------------------------R----I-AM--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VTSMALG-----S--------------GS--------------G--LFKC----------------------------------------------G--IAV------------------------------------------A-----PVAKWEYY----------------DAVYTERYM--HRPQDNFES-----------------------------------------YKNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------T--DRA-----------------------------------------------KNFKSVQ------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----GTADD--NVHF-QQAA-----------QIS-KA-L-----VEN-----------------QV---DFEAM------------W-----Y--TD-------------K------------------------------------DHSL-S-GKARYHLYTHLNHFL-KNCF------------------------------------------1051
1052 --------LQEIAMPSNMYGKLKIGEFD------LWYQMI-LPPR------FDK---------SKK-YP-----L-LID----V-------Y---------------------------------------------------------A--------------------GP--------------------------------CSQKSDFRFRV-G----WST----YLAS--TE----------------RVI-----V----------------------------------------AS------F-D---GR-GS--------------GY------QGDQIMHALYKRLG-----------TYEVED--QITA----------------------------------------------A-----------------------------R--QFID----------------------------------------M-GF---I-------DKS--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VTSMVLG-----A--------------GS--------------G--VFKC----------------------------------------------G--MAV------------------------------------------A-----PVSKWEYY----------------DSIYTERYM--LTPAENQAF-----------------------------------------YDNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------T--GRA-----------------------------------------------KSFKSVQ------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----GTADD--NVHF-QQAA-----------QIS-KA-L-----VDE-----------------QV---DFDTM------------W-----Y--TD-------------E------------------------------------DHSL-G-GSANQHVYTHMTHFL-KTCFA-----------------------------------------1052
1053 -------FLKDIQMPSKILKTISLHGEN------FWYQMI-LPPH------FDE---------SKK-YP-----L-LID----V-------Y---------------------------------------------------------A--------------------GP--------------------------------CSQKADATFKI-N----WAT----YLAS--SE----------------DII-----V----------------------------------------AS------F-D---GR-GS--------------GY------QGDKILHAIYRRLG-----------TYEVED--QILA----------------------------------------------A-----------------------------E--QFSK----------------------------------------M-RF---V-------DEK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VASMVLG-----S--------------HS--------------G--YFKC----------------------------------------------G--IAV------------------------------------------A-----PVSRWQYY----------------DSIYTERYMGLPTKEDNLHN-----------------------------------------YENSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--AKA-----------------------------------------------PYFKDVE------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QQGA-----------QIS-KA-L-----VDA-----------------EV---DFQAM------------W-----Y--TD-------------K------------------------------------DHGI-G-GHAHNHIYTHMSHFI-KQCFTL----------------------------------------1053
1054 -------FLKDIQMPSKILKTISLHGEN------FWYQMI-LPPH------FDE---------SKK-YP-----L-LID----V-------Y---------------------------------------------------------A--------------------GP--------------------------------CSQKADATFKI-N----WAT----YLAS--SE----------------DII-----V----------------------------------------AS------F-D---GR-GS--------------GY------QGDKILHAIYRRLG-----------TYEVED--QILA----------------------------------------------A-----------------------------E--QFSK----------------------------------------M-RF---V-------DEK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VASMVLG-----S--------------HS--------------G--YFKC----------------------------------------------G--IAV------------------------------------------A-----PVSRWQYY----------------DSIYTERYMGLPTKEDNLHN-----------------------------------------YENSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--AKA-----------------------------------------------PYFKDVE------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QQGA-----------QIS-KA-L-----VDA-----------------EV---DFQAM------------W-----Y--TD-------------K------------------------------------DHGI-G-GHAHNHIYTHMSHFI-KQCFTL----------------------------------------1054
1055 --------LKDIQMPSKKLGSITVGGYN------LWYQMI-LPPH------LDS---------SKK-YP-----L-LLE----V-------Y---------------------------------------------------------A--------------------GP--------------------------------CSQKVDHVFRI-N----WAT----YLAS--TE----------------QII-----V----------------------------------------AS------F-D---GR-GS--------------GY------QGDEIMHAINRRLG-----------TYEVED--QISA----------------------------------------------A-----------------------------R--TFSE----------------------------------------M-SF---V-------DKD--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VTSMVLG-----S--------------GS--------------G--VFKC----------------------------------------------G--IAV------------------------------------------A-----PVSRWQYY----------------DSIYTERYMGLPTESDNLRN-----------------------------------------YNSSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--ARA-----------------------------------------------EKFKEVE------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QQAA-----------QIS-KA-L-----VDA-----------------EV---DFQAM------------W-----Y--TD-------------K------------------------------------DHGI-S-GQAHKHIYTHMSHFI-KQCFSLP---------------------------------------1055
1056 -------MLQNVQMPSKKLDFIILNETK------FWYQMI-LPPH------FDK---------SKK-YP-----L-LLD----V-------Y---------------------------------------------------------A--------------------GP--------------------------------CSQKADTVFRL-N----WAT----YLAS--TE----------------NII-----V----------------------------------------AS------F-D---GR-GS--------------GY------QGDKIMHAINRRLG-----------TFEVED--QIEA----------------------------------------------A-----------------------------R--QFSK----------------------------------------M-GF---V-------DNK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VTSMVLG-----S--------------GS--------------G--VFKC----------------------------------------------G--IAV------------------------------------------A-----PVSRWEYY----------------DSVYTERYMGLPTPEDNLDH-----------------------------------------YRNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--SRA-----------------------------------------------ENFKQVE------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QQSA-----------QIS-KA-L-----VDV-----------------GV---DFQAM------------W-----Y--TD-------------E------------------------------------DHGIAS-STAHQHIYTHMSHFI-KQCFSLP---------------------------------------1056
1057 -------MLQNVQMPSKKLDFIILNETK------FWYQMI-LPPH------FDK---------SKK-YP-----L-LLD----V-------Y---------------------------------------------------------A--------------------GP--------------------------------CSQKADTVFRL-N----WAT----YLAS--TE----------------NII-----V----------------------------------------AS------F-D---GR-GS--------------GY------QGDKIMHAINRRLG-----------TFEVED--QIEA----------------------------------------------A-----------------------------R--QFSK----------------------------------------M-GF---V-------DNK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VTSMVLG-----S--------------GS--------------G--VFKC----------------------------------------------G--IAV------------------------------------------A-----PVSRWEYY----------------DSVYTERYMGLPTPEDNLDH-----------------------------------------YRNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--SRA-----------------------------------------------ENFKQVE------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QQSA-----------QIS-KA-L-----VDV-----------------GV---DFQAM------------W-----Y--TD-------------E------------------------------------DHGIAS-STAHQHIYTHMSHFI-KQCFSLP---------------------------------------1057
1058 -------MLQEVQMPSKKLDFIILNETK------FWYQMI-LPPH------FDT---------SKK-YP-----L-LID----V-------Y---------------------------------------------------------A--------------------GP--------------------------------CSQKADAIFRL-N----WAT----YLAS--TE----------------NII-----V----------------------------------------AS------F-D---GR-GS--------------GY------QGDKIMHAVNRRLG-----------TFEVED--QIEA----------------------------------------------A-----------------------------R--QFSK----------------------------------------M-GF---V-------DDK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VTSMVLG-----A--------------GS--------------G--VFKC----------------------------------------------G--IAV------------------------------------------A-----PVSRWEYY----------------DSVYTERYMGLPTPQDNLDY-----------------------------------------YKNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--SRA-----------------------------------------------ENFKQVE------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QQSA-----------QIS-KA-L-----VDA-----------------GV---DFQAM------------W-----Y--TD-------------E------------------------------------DHGIAS-GPAHQHIYTHMSHFI-KQCFSLP---------------------------------------1058
1059 -------MLQEVQMPSKKLDFIILNETK------FWYQMI-LPPH------FDT---------SKK-YP-----L-LID----V-------Y---------------------------------------------------------A--------------------GP--------------------------------CSQKADAIFRL-N----WAT----YLAS--TE----------------NII-----V----------------------------------------AS------F-D---GR-GS--------------GY------QGDKIMHAVNRRLG-----------TFEVED--QIEA----------------------------------------------A-----------------------------R--QFSK----------------------------------------M-GF---V-------DDK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VTSMVLG-----A--------------GS--------------G--VFKC----------------------------------------------G--IAV------------------------------------------A-----PVSRWEYY----------------DSVYTERYMGLPTPQDNLDY-----------------------------------------YKNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--SRA-----------------------------------------------ENFKQVE------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QQSA-----------QIS-KA-L-----VDA-----------------GV---DFQAM------------W-----Y--TD-------------E------------------------------------DHGIAS-GPAHQHIYTHMSHFI-KQCFSLP---------------------------------------1059
1060 -------MLQDVQMPSKKLDFIVLNETR------FWYQMI-LPPH------FDK---------SKK-YP-----L-LLD----V-------Y---------------------------------------------------------A--------------------GP--------------------------------CSQKADASFRL-N----WAT----YLAS--TE----------------NII-----V----------------------------------------AS------F-D---GR-GS--------------GY------QGDKIMHAINRRLG-----------TLEVED--QIEA----------------------------------------------A-----------------------------R--QFVK----------------------------------------M-GF---V-------DSK--------------------------------------------------------R----V-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VTSMVLG-----S--------------GS--------------G--VFKC----------------------------------------------G--IAV------------------------------------------A-----PVSRWEYY----------------DSVYTERYMGLPIPEDNLDH-----------------------------------------YRNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--SRA-----------------------------------------------EHFKQVE------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QQSA-----------QIS-KA-L-----VDA-----------------GV---DFQAM------------W-----Y--TD-------------E------------------------------------DHGIAS-STAHQHIYSHMSHFL-QQCFSL----------------------------------------1060
1061 --------LQDVQMPSKKLDSIILHETK------FWYQMI-LPPH------FDS---------SKK-YP-----L-LID----V-------Y---------------------------------------------------------A--------------------GP--------------------------------CSQKADAVFRL-N----WAT----YLAS--TE----------------NII-----V----------------------------------------AS------F-D---GR-GS--------------GY------QGDKIMHAVNRRLG-----------TFEVQD--QIDA----------------------------------------------A-----------------------------R--QFSK----------------------------------------M-GF---V-------DDK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VTSMVLG-----A--------------GS--------------G--VFKC----------------------------------------------G--IAV------------------------------------------A-----PVSRWEYY----------------DSVYTERYMGLPTPEDNLDY-----------------------------------------YRNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--SRA-----------------------------------------------ENFKQVE------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QQSA-----------QIS-KA-L-----VDA-----------------GV---DFQAM------------W-----Y--TD-------------E------------------------------------DHGIAS-STAHQHIYTHMSHFI-KQCFSLP---------------------------------------1061
1062 -------MLQDVQMPSKKLDSIILHETK------FWYQMI-LPPH------FDS---------SKK-YP-----L-LID----V-------Y---------------------------------------------------------A--------------------GP--------------------------------CSQKADAVFRL-N----WAT----YLAS--TE----------------NII-----V----------------------------------------AS------F-D---GR-GS--------------GY------QGDKIMHAVNRRLG-----------TFEVQD--QIDA----------------------------------------------A-----------------------------R--QFSK----------------------------------------M-GF---V-------DDK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VTSMVLG-----A--------------GS--------------G--VFKC----------------------------------------------G--IAV------------------------------------------A-----PVSRWEYY----------------DSVYTERYMGLPTPEDNLDY-----------------------------------------YRNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--SRA-----------------------------------------------ENFKQVE------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QQSA-----------QIS-KA-L-----VDA-----------------GV---DFQAM------------W-----Y--TD-------------E------------------------------------DHGIAS-STAHQHIYTHMSHFI-KQCFSLP---------------------------------------1062
1063 --------LQDVQMPSKTLDFIILNETK------FWYQMI-LPPH------FDK---------SKK-YP-----L-LIE----V-------Y---------------------------------------------------------G--------------------GP--------------------------------CSQKADAVFRL-N----WAT----YLAS--TE----------------NII-----V----------------------------------------AS------F-D---GR-GS--------------GY------QGDKIMHAINRRLG-----------TFEVED--QIEA----------------------------------------------A-----------------------------R--QFLK----------------------------------------M-GF---V-------DDK--------------------------------------------------------R----V-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VTSMVLG-----A--------------GS--------------G--VFKC----------------------------------------------G--IAV------------------------------------------A-----PVSRWEYY----------------DSIYTERYMGLPTPEDNLDH-----------------------------------------YRNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--SRA-----------------------------------------------ENFKQVE------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QQSA-----------QLS-KA-L-----VDA-----------------GV---DFQAM------------W-----Y--TD-------------E------------------------------------DHGIDS-STAHQHIYTHMSHFI-QQCFSL----------------------------------------1063
1064 --------LQDVQMPSKTLDFIILNETK------FWYQMI-LPPH------FDK---------SKK-YP-----L-LIE----V-------Y---------------------------------------------------------G--------------------GP--------------------------------CSQKADAVFRL-N----WAT----YLAS--TE----------------NII-----V----------------------------------------AS------F-D---GR-GS--------------GY------QGDKIMHAINRRLG-----------TFEVED--QIEA----------------------------------------------A-----------------------------R--QFLK----------------------------------------M-GF---V-------DDK--------------------------------------------------------R----V-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VTSMVLG-----A--------------GS--------------G--VFKC----------------------------------------------G--IAV------------------------------------------A-----PVSRWEYY----------------DSIYTERYMGLPTPEDNLDH-----------------------------------------YRNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--SRA-----------------------------------------------ENFKQVE------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QQSA-----------QLS-KA-L-----VDA-----------------GV---DFQAM------------W-----Y--TD-------------E------------------------------------DHGIDS-STAHQHIYTHMSHFI-QQCFSL----------------------------------------1064
1065 -------VLQDVQMPSKKLDFIHLHGTK------FWYQMI-LPPH------FDK---------SKK-YP-----L-LLE----V-------Y---------------------------------------------------------A--------------------GP--------------------------------CSQKADAIFRL-N----WAT----YLAS--TE----------------NII-----V----------------------------------------AS------F-D---GR-GS--------------GY------QGDKIMHAINRRLG-----------TFEVED--QIEA----------------------------------------------T-----------------------------R--QFSK----------------------------------------M-GF---V-------DDK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VTSMVLG-----A--------------GS--------------G--VFKC----------------------------------------------G--IAV------------------------------------------A-----PVSKWEYY----------------DSVYTERYMGLPTPEDNLDS-----------------------------------------YRNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--SRA-----------------------------------------------ENFKQVE------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QQSA-----------QIS-KA-L-----VDA-----------------GV---DFQSM------------W-----Y--TD-------------E------------------------------------DHGIAS-STAHQHIYTHMSHFL-KQCFSL----------------------------------------1065
1066 --------YKLLSLQHKVTSTIHLYTNF------IWHIIIIILPH------FPY---------SKKHWP-----VKLMN----R-------Y---------------------------------------------------------A--------------------GP--------------------------------CSQKADAIFRL-N----WAT----YLAS--TE----------------NII-----V----------------------------------------AS------F-D---GR-GS--------------GY------QGDKIMHAINRRLG-----------TFEVED--QIEA----------------------------------------------T-----------------------------R--QFSK----------------------------------------M-GF---V-------DDK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VTSMVLG-----A--------------GS--------------G--VFKC----------------------------------------------G--IAV------------------------------------------A-----PVSKWEYY----------------DSVYTERYMGLPTPEDNLDS-----------------------------------------YRNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--SRA-----------------------------------------------ENFKQVE------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QQSA-----------QIS-KA-L-----VDA-----------------GV---DFQSM------------W-----Y--TD-------------E------------------------------------DHGIAS-STAHQHIYTHMSHFL-KQCFSLL---------------------------------------1066
1067 -----------------------------------------ILPH------FPY---------SKKHWP-----VKLMN----R-------Y---------------------------------------------------------A--------------------GP--------------------------------CSQKADAIFRL-N----WAT----YLAS--TE----------------NII-----V----------------------------------------AS------F-D---GR-GS--------------GY------QGDKIMHAINRRLG-----------TFEVED--QIEA----------------------------------------------T-----------------------------R--QFSK----------------------------------------M-GF---V-------DDK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VTSMVLG-----A--------------GS--------------G--VFKC----------------------------------------------G--IAV------------------------------------------A-----PVSKWEYY----------------DSVYTERYMGLPTPEDNLDS-----------------------------------------YRNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--SRA-----------------------------------------------ENFKQVE------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QQSA-----------QIS-KA-L-----VDA-----------------GV---DFQSM------------W-----Y--TD-------------E------------------------------------DHGIAS-STAHQHIYTHMSHFL-----------------------------------------------1067
1068 ---------------------------D------LWAEMF-LPPN------FDE---------RKE-YP-----V-LFD----V-------Y---------------------------------------------------------A--------------------GP--------------------------------YSQKVNEQFRL-Y----WTA----YLTS--SL----------------DII-----V----------------------------------------AS------F-D---GR-GS--------------GY------QGEKILHEIYRKLG-----------TVEVED--QIEA----------------------------------------------G-----------------------------R--QFQN----------------------------------------L-QY---V-------DKN--------------------------------------------------------K----M-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-VTSHVIG-----R--------------GS--------------D--VFKC----------------------------------------------G--IAV------------------------------------------A-----PVTDYLYY----------------DSVYTERYM--QHPQDNEKG-----------------------------------------YNDTIV---------------------------------------------------------------------------------------------------------------------------------------------------------M--HHA-----------------------------------------------ENFKKAK------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----GTGDD--NVHF-QHTA-----------DLV-DA-L-----TKA-----------------EV---EFDLQ------------F-----Y--TD-------------Q------------------------------------DHAIR----------------------------------------------------------------1068
1069 --------LKNIQLPKEEIKKLEVNEIT------LWYKMI-LPPQ------FDR---------SKK-YP-----L-LIQ----V-------Y---------------------------------------------------------G--------------------GP--------------------------------CSQSVRSVFAI-S----WIS----YLAS--KE----------------GIV-----I----------------------------------------AL------V-D---GR-GT--------------AF------QGDKLLYAVYRKLG-----------VYEVED--QITA----------------------------------------------V-----------------------------R--KFIE----------------------------------------M-GF---I-------DEK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VSSLALA-----S--------------GT--------------G--LFKC----------------------------------------------G--IAV------------------------------------------A-----PVSSWEYY----------------ASIYTERFMGLPTKDDNLEH-----------------------------------------YKNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--ARA-----------------------------------------------EYFRNVD------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QNSA-----------QIA-KA-L-----VNA-----------------QV---DFQAM------------W-----Y--SD-------------Q------------------------------------NHGI-S-GLSTKHLYTHMTHFL-KQCFSL----------------------------------------1069
1070 ------------------IKKLEVNEISLSDFNALWYKMI-LPPQ------FDR---------SKK-YP-----L-LIQ----V-------Y---------------------------------------------------------G--------------------GP--------------------------------CSQSVRSVFAI-S----WIS----YLAS--KE----------------GIV-----I----------------------------------------AL------V-D---GR-GT--------------AF------QGDKLLYAVYRKLG-----------VYEVED--QITA----------------------------------------------V-----------------------------R--KFIE----------------------------------------M-GF---I-------DEK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VSSLALA-----S--------------GT--------------G--LFKC----------------------------------------------G--IAV------------------------------------------A-----PVSSWEYY----------------ASIYTERFMGLPTKDDNLEH-----------------------------------------YKNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--ARA-----------------------------------------------EYFRNVD------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QNSA-----------QIA-KA-L-----VNA-----------------QV---DFQAM------------W-----Y--SD-------------Q------------------------------------NHGI-S-GLSTKHLYTHMTHFL-----------------------------------------------1070
1071 ---------------RREIKKLEVNEIT------LWYKMI-LPPQ------FDR---------SKK-YP-----L-LIQ----V-------Y---------------------------------------------------------G--------------------GP--------------------------------CSQSVRSVFAI-S----WIS----YLAS--KE----------------GIV-----I----------------------------------------AL------V-D---GR-GT--------------AF------QGDKLLYAVYRKLG-----------VYEVED--QITA----------------------------------------------V-----------------------------R--KFIE----------------------------------------M-GF---I-------DEK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VSSLALA-----S--------------GT--------------G--LFKC----------------------------------------------G--IAV------------------------------------------A-----PVSSWEYY----------------ASIYTERFMGLPTKDDNLEH-----------------------------------------YKNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--ARA-----------------------------------------------EYFRNVD------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QNSA-----------QIA-KA-L-----VNA-----------------QV---DFQAM------------W-----Y--SD-------------Q------------------------------------NHGI-S-GLSTKHLYTHMTHFL-KQCFSL----------------------------------------1071
1072 --------LKNIKLPKEEIKKLEVDEIT------LWYKMI-LPPQ------FDK---------SKK-YP-----L-LIQ----V-------Y---------------------------------------------------------G--------------------GP--------------------------------CSQSVRSIFAI-S----WIS----YLAS--KE----------------GIV-----I----------------------------------------AL------V-D---GR-GT--------------AF------QGDKLLYAVYRKLG-----------VYEVED--QITA----------------------------------------------V-----------------------------R--KFIE----------------------------------------M-GF---I-------DEK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VSSLALA-----S--------------GT--------------G--LFKC----------------------------------------------G--IAV------------------------------------------A-----PVSSWEYY----------------ASIYTERFMGLPTKDDNLKH-----------------------------------------YKNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--ARA-----------------------------------------------EYFRNVD------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QNSA-----------QIA-KA-L-----VNA-----------------QV---DFQAM------------W-----Y--SD-------------Q------------------------------------NHGI-S-GLSTKHLYTHMTHFL-KQCFSL----------------------------------------1072
1073 --------LKNIKLPKEEIKKLEVDEIT------LWYKMI-LPPQ------FDK---------SKK-YP-----L-LIQ----V-------Y---------------------------------------------------------G--------------------GP--------------------------------CSQSVRSIFAI-S----WIS----YLAS--KE----------------GIV-----I----------------------------------------AL------V-D---GR-GT--------------AF------QGDKLLYAVYRKLG-----------VYEVED--QITA----------------------------------------------V-----------------------------R--KFIE----------------------------------------M-GF---I-------DEK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VSSLALA-----S--------------GT--------------G--LFKC----------------------------------------------G--IAV------------------------------------------A-----PVSSWEYY----------------ASIYTERFMGLPTKDDNLKH-----------------------------------------YKNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--ARA-----------------------------------------------EYFRNVD------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QNSA-----------QIA-KA-L-----VNA-----------------QV---DFQAM------------W-----Y--SD-------------Q------------------------------------NHGI-S-GLSTKHLYTHMTHFL-KQCFSL----------------------------------------1073
1074 --------LKNIQLPKEEIKKLEVDEIT------LWYKMI-LPPQ------FDR---------SKK-YP-----L-LIQ----V-------Y---------------------------------------------------------G--------------------GP--------------------------------CSQSVRSVFAV-N----WIS----YLAS--KE----------------GMV-----I----------------------------------------AL------V-D---GR-GT--------------AF------QGDKLLYAVYRKLG-----------VYEVED--QITA----------------------------------------------V-----------------------------R--KFIE----------------------------------------M-GF---I-------DEK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VSSLALA-----S--------------GT--------------G--LFKC----------------------------------------------G--IAV------------------------------------------A-----PVSSWEYY----------------ASVYTERFMGLPTKDDNLEH-----------------------------------------YKNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--ARA-----------------------------------------------EYFRNVD------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QNSA-----------QIA-KA-L-----VNA-----------------QV---DFQAM------------W-----Y--SD-------------Q------------------------------------NHGL-S-GLSTNHLYTHMTHFL-KQCFSL----------------------------------------1074
1075 --------LKNIQLPKEEIKKLEVDEIT------LWYKMI-LPPQ------FDR---------SKK-YP-----L-LIQ----V-------Y---------------------------------------------------------G--------------------GP--------------------------------CSQSVRSVFAV-N----WIS----YLAS--KE----------------GMV-----I----------------------------------------AL------V-D---GR-GT--------------AF------QGDKLLYAVYRKLG-----------VYEVED--QITA----------------------------------------------V-----------------------------R--KFIE----------------------------------------M-GF---I-------DEK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VSSLALA-----S--------------GT--------------G--LFKC----------------------------------------------G--IAV------------------------------------------A-----PVSSWEYY----------------ASVYTERFMGLPTKDDNLEH-----------------------------------------YKNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--ARA-----------------------------------------------EYFRNVD------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QNSA-----------QIA-KA-L-----VNA-----------------QV---DFQAM------------W-----Y--SD-------------Q------------------------------------NHGL-S-GLSTNHLYTHMTHFL-KQCFSL----------------------------------------1075
1076 --------LKNIQLPKEEIKKLKVDDIT------LWYKMI-LPPQ------FDK---------SKK-YP-----L-LIQ----V-------Y---------------------------------------------------------G--------------------GP--------------------------------CSQSVRSIFAV-S----WIS----YLAS--KE----------------GIV-----I----------------------------------------AL------V-D---GR-GT--------------AF------QGDKLLYAVYRKLG-----------VYEVED--QITA----------------------------------------------V-----------------------------R--KFIE----------------------------------------M-GF---I-------DEK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VSSLALA-----S--------------GT--------------G--LFKC----------------------------------------------G--IAV------------------------------------------A-----PVSSWEYY----------------ASIYTERFMGLPTKDDNLKH-----------------------------------------YKNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--ARA-----------------------------------------------EYFRNVD------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QNSA-----------QIA-KA-L-----VNA-----------------QV---DFQAM------------W-----Y--SD-------------Q------------------------------------NHGL-S-GLSTKHLYTHMTHFL-KQCFSL----------------------------------------1076
1077 --------LKNIQLPKEEIKKLEVDDIT------LWYKMM-LPPR------FDR---------SKK-YP-----L-LIQ----V-------Y---------------------------------------------------------G--------------------GP--------------------------------CSQSVKSVFSI-N----WIS----YLAS--KE----------------GIV-----I----------------------------------------AL------V-D---GR-GT--------------AY------QGDKLLYAVYRKLG-----------VYEVED--QITA----------------------------------------------V-----------------------------R--KFIE----------------------------------------M-GF---I-------DEK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VSSLALA-----S--------------GT--------------G--LFKC----------------------------------------------G--IAV------------------------------------------A-----PVSSWEYY----------------ASIYTERFMGLPTKNDNLEH-----------------------------------------YKNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--ARA-----------------------------------------------EYFRNVD------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QNSA-----------QIA-KA-L-----VNA-----------------QV---DFQAM------------W-----Y--SD-------------Q------------------------------------NHGI-P-GLSSKHLYTRMTHFL-KQCFSLS---------------------------------------1077
1078 --------LKNIQLPKEEIKKLEVDDIT------LWYKMM-LPPR------FDR---------SKK-YP-----L-LIQ----V-------Y---------------------------------------------------------G--------------------GP--------------------------------CSQSVKSVFSI-N----WIS----YLAS--KE----------------GIV-----I----------------------------------------AL------V-D---GR-GT--------------AY------QGDKLLYAVYRKLG-----------VYEVED--QITA----------------------------------------------V-----------------------------R--KFIE----------------------------------------M-GF---I-------DEK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VSSLALA-----S--------------GT--------------G--LFKC----------------------------------------------G--IAV------------------------------------------A-----PVSSWEYY----------------ASIYTERFMGLPTKNDNLEH-----------------------------------------YKNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--ARA-----------------------------------------------EYFRNVD------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QNSA-----------QIA-KA-L-----VNA-----------------QV---DFQAM------------W-----Y--SD-------------Q------------------------------------NHGI-P-GLSSKHLYTRMTHFL-KQCFSL----------------------------------------1078
1079 --------LRNIQLPKVEIKKLKDGGLT------FWYKMI-LPPQ------FDR---------SKK-YP-----L-LIQ----V-------Y---------------------------------------------------------G--------------------GP--------------------------------CSQSVKSVFAV-N----WIT----YLAS--KE----------------GIV-----I----------------------------------------AL------V-D---GR-GT--------------AF------QGDKFLHAVYRKLG-----------VYEVED--QLTA----------------------------------------------V-----------------------------R--KFIE----------------------------------------M-GF---I-------DEE--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VSSLALA-----S--------------GT--------------G--LFKC----------------------------------------------G--IAV------------------------------------------A-----PVSSWEYY----------------ASIYSERFMGLPTKDDNLEH-----------------------------------------YKNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--ARA-----------------------------------------------EYFRNVD------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QNSA-----------QIA-KA-L-----VNA-----------------QV---DFQAM------------W-----Y--SD-------------Q------------------------------------NHGISS-GRSQNHLYTHMTHFL-KQCFSL----------------------------------------1079
1080 --------LRNIQLPKVEIKKLKDGGLT------FWYKMI-LPPQ------FDR---------SKK-YP-----L-LIQ----V-------Y---------------------------------------------------------G--------------------GP--------------------------------CSQSVKSVFAV-N----WIT----YLAS--KE----------------GIV-----I----------------------------------------AL------V-D---GR-GT--------------AF------QGDKFLHAVYRKLG-----------VYEVED--QLTA----------------------------------------------V-----------------------------R--KFIE----------------------------------------M-GF---I-------DEE--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VSSLALA-----S--------------GT--------------G--LFKC----------------------------------------------G--IAV------------------------------------------A-----PVSSWEYY----------------ASIYSERFMGLPTKDDNLEH-----------------------------------------YKNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--ARA-----------------------------------------------EYFRNVD------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QNSA-----------QIA-KA-L-----VNA-----------------QV---DFQAM------------W-----Y--SD-------------Q------------------------------------NHGISS-GRSQNHLYTHMTHFL-KQCFSL----------------------------------------1080
1081 --------LQEIILPKEEINKLEVDGIT------LWYKML-IPPQ------FDR---------SKK-YP-----L-LIQ----V-------Y---------------------------------------------------------G--------------------GP--------------------------------CSQNVKHTFSI-S----WIT----YLAS--KE----------------GII-----V----------------------------------------AL------V-D---GR-GT--------------AY------QGDKILHAVYRRLG-----------VYEVED--QISA----------------------------------------------V-----------------------------K--KFIE----------------------------------------M-GF---I-------DEK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VTSLALG-----S--------------GS--------------G--VFKC----------------------------------------------G--IAV------------------------------------------A-----PVSSWEYY----------------ASIYTERFMGLPVESDNLEH-----------------------------------------YKNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--ARA-----------------------------------------------KNFQNVE------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QNSA-----------QIA-KA-L-----VNA-----------------QV---DFQAM------------W-----Y--TD-------------Q------------------------------------NHGI-P-GLSSKHLYTHMTHFL-KQCFSLS---------------------------------------1081
1082 --------LQEIIPPKEEINKLEVDGIT------LWYKML-IPPQ------FDR---------SKK-YP-----L-LIQ----V-------Y---------------------------------------------------------G--------------------GP--------------------------------CSQNVKHTFSI-S----WIT----YLAS--KE----------------GII-----V----------------------------------------AL------V-D---GR-GT--------------AY------QGDKILHAVYRRLG-----------VYEVED--QISA----------------------------------------------V-----------------------------K--KFIE----------------------------------------M-GF---I-------DEK--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VTSLALG-----S--------------GS--------------G--VFKC----------------------------------------------G--IAV------------------------------------------A-----PVSSWEYY----------------ASIYTERFMGLPVESDNLEH-----------------------------------------YKNSTV---------------------------------------------------------------------------------------------------------------------------------------------------------M--ARA-----------------------------------------------KNFQNVE------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QNSA-----------QIA-KA-L-----VNA-----------------QV---DFQAM------------W-----Y--TD-------------Q------------------------------------NHGI-P-GLSSKHLYTHMTHFL-KQCFSL----------------------------------------1082
1083 ------------------------------------FQRLHLPPN------FNE---------SKK-YP-----M-LVQ----V-------Y---------------------------------------------------------S--------------------GP--------------------------------AYQQVRDRFEV-S----WKD----YVSS--AR----------------DVI-----V----------------------------------------MS------F-D---GR-GT--------------GY------RGDKIMHQVYKKLG-----------QYEPHD--QIAA----------------------------------------------A-----------------------------R--KLATE---------------------------------------N-QF---I-------DQS--------------------------------------------------------K----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-ELLNVIG-----E--------------DA-------------DN--VFKC----------------------------------------------G--FAV------------------------------------------A-----PVTKWEYY----------------HTIWTEKYMQQP--KDNPDG-----------------------------------------YAKGSA---------------------------------------------------------------------------------------------------------------------------------------------------------L--QGI-----------------------------------------------ENFRTHH------------------------------------------------------FN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LF-H-----GTKDE--NVHF-QNSA-----------QLS-KY-L-----IDG-----------------DV---KFGAF------------F-----A--AD-------------D------------------------------------DHSMSRVNNGYRNIYKQLTRQM-DLCFNL----------------------------------------1083
1084 --------------------------------------RLHLPPN------FNE---------SKK-YP-----M-LVQ----V-------Y---------------------------------------------------------S--------------------GP--------------------------------AYQQVRDRFEV-S----WKD----YVSS--AR----------------DVI-----V----------------------------------------MS------F-D---GR-GT--------------GY------RGDKIMHQVYKKLG-----------QYEPHD--QIAA----------------------------------------------A-----------------------------R--KLATE---------------------------------------N-QF---I-------DQS--------------------------------------------------------K----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-ELLNVIG-----E--------------DA-------------DN--VFKC----------------------------------------------G--FAV------------------------------------------A-----PVTKWEYY----------------HTIWTEKYMQQP--KDNPDG-----------------------------------------YAKGSA---------------------------------------------------------------------------------------------------------------------------------------------------------L--QGI-----------------------------------------------ENFRTHH------------------------------------------------------FN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LF-H-----GTKDE--NVHF-QNSA-----------QLS-KY-L-----IDG-----------------DV---KFGAF------------F-----A--AD-------------D------------------------------------DHSMSRVNNG-----------------------------------------------------------1084
1085 --------------------------------------RLHLPPN------FNE---------SKK-YP-----M-LVQ----V-------Y---------------------------------------------------------S--------------------GP--------------------------------AYQQVRDRFEV-S----WKD----YVSS--AR----------------DVI-----V----------------------------------------MS------F-D---GR-GT--------------GY------RGDKIMHQVYKKLG-----------QYEPHD--QIAA----------------------------------------------A-----------------------------R--KLATE---------------------------------------N-QF---I-------DQS--------------------------------------------------------K----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-ELLNVIG-----E--------------DA-------------DN--VFKC----------------------------------------------G--FAV------------------------------------------A-----PVTKWEYY----------------HTIWTEKYMQQP--KDNPDG-----------------------------------------YAKGSA---------------------------------------------------------------------------------------------------------------------------------------------------------L--QGI-----------------------------------------------ENFRTHH------------------------------------------------------FN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LF-H-----GTKDE--NVHF-QNSA-----------QLS-KY-L-----IDG-----------------DV---KFGAF------------F-----A--AD-------------D------------------------------------DHSMSRVNNG-----------------------------------------------------------1085
1086 --------------------------------------MLHLPPN------FNE---------SKK-YP-----M-LVQ----V-------Y---------------------------------------------------------S--------------------GP--------------------------------AYQQVRDRFEV-S----WKD----YVSS--AR----------------DVI-----V----------------------------------------MS------F-D---GR-GT--------------GY------RGDKIMHQVYKKLG-----------QYEPHD--QIAA----------------------------------------------A-----------------------------R--KLATE---------------------------------------N-QF---I-------DQS--------------------------------------------------------K----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-ELLNVIG-----E--------------DA-------------DN--VFKC----------------------------------------------G--FAV------------------------------------------A-----PVTKWEYY----------------HTIWTEKYMQQP--KDNPDG-----------------------------------------YAKGSA---------------------------------------------------------------------------------------------------------------------------------------------------------L--QGI-----------------------------------------------ENFRTHH------------------------------------------------------FN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LF-H-----GTKDE--NVHF-QNSA-----------QLS-KY-L-----IDG-----------------DV---KFGAF------------F-----A--AD-------------D------------------------------------DHSMSRVNNG-----------------------------------------------------------1086
1087 ----------------------------------EWFYMLQLPPN------FDE---------SKK-YP-----M-LVQ----V-------Y---------------------------------------------------------S--------------------GP--------------------------------AYQEVEDRFGV-S----WKD----YVSS--AR----------------DVI-----V----------------------------------------MS------F-D---GR-GT--------------GF------RGDEIMHQVYRKLG-----------QYEPHD--QIAA----------------------------------------------A-----------------------------K--KLANE---------------------------------------N-SF---I-------DET--------------------------------------------------------R----M-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-ATSRTIG-----E--------------DV-------------NN--VFKC----------------------------------------------G--FAV------------------------------------------A-----PVTKWEYY----------------HTIYTERYMQQP--KDNPDG-----------------------------------------YEKSTT---------------------------------------------------------------------------------------------------------------------------------------------------------L--QGI-----------------------------------------------ESFRSHH------------------------------------------------------YN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LF-H-----GTRDE--NVHF-QNSA-----------QLS-KY-L-----IEG-----------------DV---KFGAF------------F-----A--AD-------------D------------------------------------DHSMSRVDNGYKNIYKLLTRQM-EICFNL----------------------------------------1087
1088 -------------LNDYYFRERIYGNLTLPGISGEWFYMLQLPPN------FDE---------SKK-YP-----M-LVQ----V-------Y---------------------------------------------------------S--------------------GP--------------------------------AYQEVEDRFGV-S----WKD----YVSS--AR----------------DVI-----V----------------------------------------MS------F-D---GR-GT--------------GF------RGDEIMHQVYRKLG-----------QYEPHD--QIAA----------------------------------------------A-----------------------------K--KLANE---------------------------------------N-SF---I-------DET--------------------------------------------------------R----M-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-ATSRTIG-----E--------------DV-------------NN--VFKC----------------------------------------------G--FAV------------------------------------------A-----PVTKWEYY----------------HTIYTERYMQQP--KDNPDG-----------------------------------------YEKSTT---------------------------------------------------------------------------------------------------------------------------------------------------------L--QGI-----------------------------------------------ESFRSHH------------------------------------------------------YN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LF-H-----GTRDE--NVHF-QNSA-----------QLS-KY-L-----IEG-----------------DV---KFGAF------------F-----A--AD-------------D------------------------------------DHSMSRVDNGYKNIYKLLTRQM-EICF------------------------------------------1088
1089 -----------TQWPTYRYRDYTIDGNT------YWAEMI-LPPD------FSE---------DSK-YP-----V-LLD----V------------------------------------------------------------------------------------------------------------------------------------------------------TE----------------GVI-----V----------------------------------------VS------F-D---GR-GS--------------GY------QGDKVLYELHEKFG-----------TVEVRD--QIFV----------------------------------------------A-----------------------------K--ELAK----------------------------------------I-DY---I-------DET--------------------------------------------------------R----I-GI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-VTTMVAG-----E--------------GD--------------G--VFKC----------------------------------------------A--AAV------------------------------------------A-----PVVDWRLY----------------DSVYAERYMGDPHHPKNSRA-----------------------------------------YDAANA---------------------------------------------------------------------------------------------------------------------------------------------------------YSGHRI-----------------------------------------------KEFSKLE-G--------------------------N-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI-H-----GTADD--NVHF-QNTA-----------LLN-KA-L-----VEN-----------------DI---DYRVQ------------IAEAKLV--TG-------------Q------------------------------------WHGKTTLSA------------------------------------------------------------1089
1090 ---------------------------------------MFLPPG------LKVDH-------ITQ-YP-----L-LVH----T-------Y---------------------------------------------------------G--------------------GP--------------------------------NTQLVTEEFRI-G----WST----YLGS--KE----------------NVI-----Y----------------------------------------AS------I-D---GR-GS--------------VG------RGLRFLHATYKKLG-----------QLEVQD--QIAG----------------------------------------------A-----------------------------K--FLRDN---------------------------------------Y-NF---V-------DGE--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-VAAHALG-----D--------------AD-------------QK--VISC----------------------------------------------G--ISV------------------------------------------A-----PVTDWRYY----------------DTAYTERYMGFASSDDNFRG-----------------------------------------YDRANI---------------------------------------------------------------------------------------------------------------------------------------------------------S--QKA-----------------------------------------------ENFIGKK------------------------------------------------------YM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-H-----GTADD--NVHF-QHTA-----------QFT-KA-L-----TEA-----------------EV---DYRMQ------------V-----Y--SD-------------N------------------------------------NHALSG-EHTGRHLHRTMTSFLK----------------------------------------------1090
1091 --------LENKARPIREYLYIKDDNGD------EIMAEIFFPPM------LNEEH-------ITK-YP-----M-LIN----T-------Y---------------------------------------------------------G--------------------GP--------------------------------GTQRVTKQFSV-G----FET----YMST--KE----------------NTV-----Y----------------------------------------ML------I-D---GH-GS--------------GG------RGDTWLHSIYRRLG-----------TKEVED--QILG----------------------------------------------A-----------------------------R--FARER---------------------------------------F-KF---I-------DPE--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-VTAHALG-----H--------------SG-------------ND--VISC----------------------------------------------G--VAV------------------------------------------A-----PVTDFRYY----------------DTAYTEKFMGLAHSDDNYKG-----------------------------------------YDESNV---------------------------------------------------------------------------------------------------------------------------------------------------------A--YKA-----------------------------------------------VNFKDKH------------------------------------------------------FM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AV-H-----GTGDD--NVHF-QHTA-----------QLA-KA-L-----TEA-----------------EV---EFRTQ------------I-----Y--AD-------------Q------------------------------------NHALAS-PKTNLHLYRCILHFLKD---------------------------------------------1091
1092 --------VESVKWPRKIYGTFASSDYP---TKPYNYEMW-VPAD------FDP---------TKK-YP-----V-LLE----V-------Y---------------------------------------------------------A--------------------GP--------------------------------EFQKIQDVWRK-G----FAQ---TYMVS--TR----------------DVI-----V----------------------------------------VS------V-D---GR-GS--------------AF------EGYKFMRQVYLKLG-----------QYEPVD--QTAF----------------------------------------------V-----------------------------R--YLIDT---------------------------------------Y-DY---V-------DAS--------------------------------------------------------H----V-AL--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-TTSHTIG-----Y--------------DG--------------GK-TFQC----------------------------------------------G--LAV------------------------------------------A-----PLGDWTWY----------------DAMYAERYMGNL--TTNADGLSFY-------------------------------------FQKASI---------------------------------------------------------------------------------------------------------------------------------------------------------VRGHDL-----------------------------------------------NNFKNAW------------------------------------------------------YT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QSAA-----------EME-KA-L-----VEH-----------------DV---DFDDF------------F-----Y--AD-------------Q------------------------------------AHSINI-GNANKHIYRQIDLRL-SHCLG-----------------------------------------1092
1093 ------------------------------------YEMW-VPAD------FDP---------TKK-YP-----V-LLE----V-------Y---------------------------------------------------------A--------------------GP--------------------------------EFQKIQDVWRK-G----FAQ---TYMVS--TR----------------DVI-----V----------------------------------------VS------V-D---GR-GS--------------AF------EGYKFMRQVYLKLG-----------QYEPVD--QTAF----------------------------------------------V-----------------------------R--YLIDT---------------------------------------Y-DY---V-------DAS--------------------------------------------------------H----V-AL--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-TTSHTIG-----Y--------------DG--------------GK-TFQC----------------------------------------------G--LAV------------------------------------------A-----PLGDWTWY----------------DAMYAERYMGNL--TTNADG-----------------------------------------YEKASI---------------------------------------------------------------------------------------------------------------------------------------------------------VRGHDL-----------------------------------------------NNFKNAW------------------------------------------------------YT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QSAA-----------EME-KA-L-----VEH-----------------DV---DFDDF------------F-----Y--AD-------------Q------------------------------------AHSINI-GNANKHIYRQIDLRL-SHC-------------------------------------------1093
1094 ------------EMPVKSYGNIDSK--T---GYKFRYERL-DPPN------FDV---------NKK-YP-----L-LIE----V-------Y---------------------------------------------------------A--------------------GP--------------------------------GYQNVDAFWSR-S----WGS---AYVPA--GL----------------GVI-----L----------------------------------------VR------I-D---GR-GS--------------NF------YGDEFMHEVYQGLG-----------QKEIED--QIEA----------------------------------------------A-----------------------------E--YF-GK---------------------------------------L-PE---V-------DSS--------------------------------------------------------K----I-AM--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-ATSHALG-----L--------------NT--------------G--ILKC----------------------------------------------G--MAV------------------------------------------A-----PLVDWRYY----------------DTIYAERYMGLP--AINTDG-----------------------------------------YDKANI---------------------------------------------------------------------------------------------------------------------------------------------------------I--NKA-----------------------------------------------ENFPQSS------------------------------------------------------YY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QNSA-----------QLS-KA-L-----VEN-----------------DI---RFNNF------------F-----Y--AD-------------Q------------------------------------DHSINV-GNAYTHVYKVLTRQL-CQCFNL----------------------------------------1094
1095 --------LANKALPITEYVNIPINNKE------SMYAKMLLPPI------LDQ-KQ------HYT-YP-----L-LLS----V-------Y---------------------------------------------------------G--------------------GP--------------------------------DTQKVTYKFQL-S----WED----YLVS--SK----------------NYI-----V----------------------------------------AY------A-D---GR-GG--------------AG------RGQKWLHANYKNLG-----------SLEVTD--AITA----------------------------------------------G-----------------------------R--YFNN----------------------------------------I-AY---V-------ESS--------------------------------------------------------K----K-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-TTASVIG-----Q--------------GD--------------G--LFEC----------------------------------------------G--ISV------------------------------------------A-----PVTDWHYY----------------DSVYTERYMGMP--HENEIG-----------------------------------------YTNSNV---------------------------------------------------------------------------------------------------------------------------------------------------------S--QYA-----------------------------------------------AKFKNVK------------------------------------------------------YM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----GTGDD--NVHF-QNSA-----------QFI-KA-L-----VEK-----------------DV---FFRLQ------------V-----Y--TD-------------Q------------------------------------QHGLSG-GNTKKHLYESMEDFL-GECF------------------------------------------1095
1096 --------LANKALPITEYVNIPINNKE------SMYAKMLLPPI------LDQ-KQ------HYT-YP-----L-LLS----V-------Y---------------------------------------------------------G--------------------GP--------------------------------DTQKVTYKFQL-S----WED----YLVS--SK----------------NYI-----V----------------------------------------AY------A-D---GR-GG--------------AG------RGQKWLHANYKNLG-----------SLEVTD--AITA----------------------------------------------G-----------------------------R--YFNN----------------------------------------I-AY---V-------ESS--------------------------------------------------------K----K-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-TTASVIG-----Q--------------GD--------------G--LFEC----------------------------------------------G--ISV------------------------------------------A-----PVTDWHYY----------------DSVYTERYMGMP--HENEIG-----------------------------------------YTNSNV---------------------------------------------------------------------------------------------------------------------------------------------------------S--QYA-----------------------------------------------AKFKNVK------------------------------------------------------YM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----GTGDD--NVHF-QNSA-----------QFI-KA-L-----VEK-----------------DV---FFRLQ------------V-----Y--TD-------------Q------------------------------------QHGLSG-GNTKKHLYESMEDFL-GECF------------------------------------------1096
1097 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HSVYRQLG-----------QLETVD--QLRG----------------------------------------------A-----------------------------R--FFQE----------------------------------------K-CY---V-------DSS--------------------------------------------------------H----F-AI--Y-G--SS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MAGMIES-----S--------------GT--------------G--VFTA----------------------------------------------A--ISQ------------------------------------------S-----PVSDWHYY----------------DSIYTERYMNQP--TDNSDG-----------------------------------------YRVTSL---------------------------------------------------------------------------------------------------------------------------------------------------------L--TRL-----------------------------------------------SNVSVESLP--------------------------H-------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTGDD--NVHF-QNTA-----------QLI-SV-L-----TER-----------------EI---QYQLM------------V-----Y--TD-------------Q------------------------------------DHSLSG-GKTRNHLYQLITDFL-----------------------------------------------1097
1098 ---------------------------------------I-LPPN------LDI-TG------RKK-YP-----V-LIR----V-------Y---------------------------------------------------------G--------------------GP--------------------------------GSQMVSNRFER-D----WHS----YLAA--SQ----------------RYI-----I----------------------------------------IM------L-D---GR-GT--------------GF------RGRNLRNPVRDDLG-----------HWEVQD--QVAA----------------------------------------------A-----------------------------R--EMAK----------------------------------------R-VY---V-------DRS--------------------------------------------------------R----I-GI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTCKAIE-----A--------------DS--------------G--IFTL----------------------------------------------G--MAV------------------------------------------A-----PVTDWRYY----------------DSIYTERYMSTP--SANKDG-----------------------------------------YATSAV---------------------------------------------------------------------------------------------------------------------------------------------------------N--N-V-----------------------------------------------TSFSG-DKV--------------------------D-------------------------FI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WA-H-----GSGDD--NVHY-MNSA-----------ALL-DK-L-----TQE-----------------QV--RGWRFR------------M-----F--TD-------------S------------------------------------NHSMDK-RMAYREVYEWMNDFL-EE--------------------------------------------1098
1099 ---------------------------------------I-LPPN------LDI-TG------RKK-YP-----V-LIR----V-------Y---------------------------------------------------------G--------------------GP--------------------------------GSQMVSNRFER-D----WHS----YLAA--SQ----------------RYI-----I----------------------------------------IM------L-D---GR-GT--------------GF------RGRNLRNPVRDDLG-----------HWEVQD--QVAA----------------------------------------------A-----------------------------R--EMAK----------------------------------------R-VY---V-------DRS--------------------------------------------------------R----I-GI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTCKAIE-----A--------------DS--------------G--IFTL----------------------------------------------G--MAV------------------------------------------A-----PVTDWRYY----------------DSIYTERYMSTP--SANKDG-----------------------------------------YTTSAV---------------------------------------------------------------------------------------------------------------------------------------------------------N--N-V-----------------------------------------------TSFSG-DKV--------------------------D-------------------------FI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WA-H-----GSGDD--NVHY-MNSA-----------ALL-DK-L-----TQE-----------------QV--RGWRFR------------M-----F--TD-------------S------------------------------------NHSMDK-RMAYREVYEWMNDFL-EE--------------------------------------------1099
1100 ---------------------------------------I-LPPN------LDI-TG------RKK-YP-----V-LIR----V-------Y---------------------------------------------------------G--------------------GP--------------------------------GSQMVSNRFER-D----WHS----YLAA--SQ----------------RYI-----I----------------------------------------IM------L-D---GR-GT--------------GF------RGRNLRNPVRDDLG-----------HWEVQD--QVAA----------------------------------------------A-----------------------------R--EMAK----------------------------------------R-VY---V-------DRS--------------------------------------------------------R----I-GI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTCKAIE-----A--------------DS--------------G--IFTL----------------------------------------------G--MAV------------------------------------------A-----PVTDWRYY----------------DSIYTERYMSTP--SANKDG-----------------------------------------YATSAV---------------------------------------------------------------------------------------------------------------------------------------------------------N--N-V-----------------------------------------------TSFSG-DKV--------------------------D-------------------------FI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WA-H-----GSGDD--NVHY-MNSA-----------ALL-DK-L-----TQE-----------------QV--RGWRFR------------M-----F--TD-------------S------------------------------------NHSMDK-RMAYREVYEWMNDFL-EE--------------------------------------------1100
1101 --------------------PLVTRTTIENDGYELNMLEI-LPPN------LDI-TG------RKK-YP-----V-LIR----V-------Y---------------------------------------------------------G--------------------GP--------------------------------GSQMVSNRFER-D----WHS----YLAA--SQ----------------RYI-----I----------------------------------------IM------L-D---GR-GT--------------GF------RGRNLRNPVRDDLG-----------HWEVQD--QVAA----------------------------------------------A-----------------------------R--EMAK----------------------------------------R-VY---V-------DRS--------------------------------------------------------R----I-GI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTCKAIE-----A--------------DS--------------G--IFTL----------------------------------------------G--MAV------------------------------------------A-----PVTDWLYY----------------DSIYTERYMSTP--SANKDG-----------------------------------------YTTSAV---------------------------------------------------------------------------------------------------------------------------------------------------------N--N-V-----------------------------------------------TSFSG-DKV--------------------------D-------------------------FI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WA-H-----GSGDD--NVHY-MNSA-----------ALL-DK-L-----TQE-----------------QV--RGWRFR------------M-----F--TD-------------S------------------------------------NHSMDK-RMAYREVYEWMNDFL-----------------------------------------------1101
1102 -----------------------TRTTIENDGYELNMLEI-LPPN------LDI-TG------RKK-YP-----V-LIR----V-------Y---------------------------------------------------------G--------------------GP--------------------------------GSQMVSNRFER-D----WHS----YLAA--SQ----------------RYI-----I----------------------------------------IM------L-D---GR-GT--------------GF------RGRNLRNPVRDDLG-----------HWEVQD--QVAA----------------------------------------------A-----------------------------R--EMAK----------------------------------------R-VY---V-------DRS--------------------------------------------------------R----I-GI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTCKAIE-----A--------------DS--------------G--IFTL----------------------------------------------G--MAV------------------------------------------A-----PVTDWRYY----------------DSIYTERYMSTP--SANKDG-----------------------------------------YTTSAV---------------------------------------------------------------------------------------------------------------------------------------------------------N--N-V-----------------------------------------------TSFSG-DRV--------------------------D-------------------------FI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WA-H-----GSGDD--NVHY-MNSA-----------ALL-DK-L-----TQE-----------------QV--RGWRFR------------M-----F--TD-------------S------------------------------------NHSMDK-RMAYREVYEWMNDF------------------------------------------------1102
1103 --------------------PIVTYSTLMSDGYELNVKET-RPPK------FDD-SG------RTK-YP-----V-LFY----V-------Y---------------------------------------------------------G--------------------GP--------------------------------FSQQVDARWPR-T--A-WSN----YLAA--GL----------------GYI-----V----------------------------------------VS------V-D---GR-GT--------------GY------KGRKLRNPVKNNLG-----------FFETID--QIEA----------------------------------------------A-----------------------------R--QYVR----------------------------------------K-PY---V-------DSK--------------------------------------------------------R----I-GI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MSSKVVE-----A--------------NE--------------G--VHTL----------------------------------------------A--MAV------------------------------------------A-----PVTSWLLY----------------DTIYTERYMNLP--ALNPGG-----------------------------------------YVNASI---------------------------------------------------------------------------------------------------------------------------------------------------------S--N-V-----------------------------------------------TGFHN---V--------------------------D-------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LA-H-----GSGDD--NVHY-SNSA-----------HLL-DM-F-----TQA-----------------KV--RKYRFR------------M-----F--TD-------------S------------------------------------DHSIAR-RGANREVYEYLTAFL-----------------------------------------------1103
1104 -------------------------------------KMI-VPPD------FDP-SG------KTK-YP-----V-LMQ----V-------Y---------------------------------------------------------G--------------------GP--------------------------------YSQMVNQKW----------NLDFMYHLP--LI----------------GFV-----S----------------------------------------VI------V-D---GR-GT--------------GF------KGRKFRNAVSKQLG-----------LHEVED--QIEA----------------------------------------------G-----------------------------R--WLGQ----------------------------------------Q-KY---I-------DSK--------------------------------------------------------K----I-GI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MAAKCIE-----A--------------NS--------------G--VFAL----------------------------------------------G--MSV------------------------------------------A-----PVTDWRFY----------------DTVYTERYMKTP--VQNPEG-----------------------------------------YAKSAV---------------------------------------------------------------------------------------------------------------------------------------------------------S--N-M-----------------------------------------------TGFSQ---S--------------------------R-------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTGDD--NVHF-QNSA-----------MLV-WH-F-----TGA-----------------NLSPKNVRVQ------------Y-----Y--TD-------------S------------------------------------DHSISD-NGANPQVFGLLTSYA-CDTFRL----------------------------------------1104
1105 -------------------------TIPNQIGNDMNVKMI-VPPD------FDP-SG------KTK-YP-----V-LMQ----V-------Y---------------------------------------------------------G--------------------GP--------------------------------YSQMVNQKW----------NLDFMYHLP--LI----------------GFV-----S----------------------------------------VI------V-D---GR-GT--------------GF------KGRKFRNAVSKQLG-----------LHEVED--QIEA----------------------------------------------G-----------------------------R--WLGQ----------------------------------------Q-KY---I-------DSK--------------------------------------------------------K----I-GI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MAAKCIE-----A--------------NS--------------G--VFAL----------------------------------------------G--MSV------------------------------------------A-----PVTDWRFY----------------DTVYTERYMKTP--VQNPEG-----------------------------------------YAKSAV---------------------------------------------------------------------------------------------------------------------------------------------------------S--N-M-----------------------------------------------TGFSQ---S--------------------------R-------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTGDD--NVHF-QNSA-----------MLV-WH-F-----TGA-----------------NLSPKNVRVQ------------Y-----Y--TD-------------S------------------------------------DHSISD-NGANPQVFGLLTSY------------------------------------------------1105
1106 --------LKEYSFNYPKFQELNLGDDSEGQKVIANSYEI-LPPD------FDS-NL------RNH-YP-----V-FFF----A-------Y---------------------------------------------------------G--------------------GP--------------------------------GSQLVKKEFAV-S----FLQ----VVAA--QL----------------DAI-----V----------------------------------------VV------V-D---GR-GT--------------GF------KGKPFRAVVTGDLG-----------HYEAED--QIAA----------------------------------------------A-----------------------------K--LYSE----------------------------------------K-YY---V-------NKE--------------------------------------------------------R----I-SL--F-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LTLKTLE-----R--------------DA--------------GR-YFKY----------------------------------------------G--IAV------------------------------------------A-----PVTDWRLY----------------DSVYTERYMSEP--LSNPRG-----------------------------------------YADAKV---------------------------------------------------------------------------------------------------------------------------------------------------------H--N-V-----------------------------------------------SALAK--VP--------------------------R-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-H-----GTGDD--NVHF-QHTL-----------VLL-DQ-L-----NLA-----------------GV--ENYDLL------------V-----F--PD-------------S------------------------------------RHSIDI-HNANVIVYDKILNWA-NQAY------------------------------------------1106
1107 -------ILEDYAVPRKSFRELNLGKDEFGKDILVNSYEI-LPND------FDE-TL------SDH-YP-----V-FFF----A-------Y---------------------------------------------------------G--------------------GP--------------------------------NSQQVVKTFSV-G----FNE----VVAS--QL----------------NAI-----V----------------------------------------VV------V-D---GR-GT--------------GF------KGQDFRSLVRDRLG-----------DYEARD--QISA----------------------------------------------A-----------------------------S--LYGS----------------------------------------L-TF---V-------DPQ--------------------------------------------------------K----I-SL--F-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LTLKTLE-----K--------------DG--------------GR-HFKY----------------------------------------------G--MSV------------------------------------------A-----PVTDWRFY----------------DSVYTERYMHTP--QENFDG-----------------------------------------YVESSV---------------------------------------------------------------------------------------------------------------------------------------------------------H--N-V-----------------------------------------------TALAQ--AN--------------------------R-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-H-----GTGDD--NVHF-QNSL-----------KFL-DL-L-----DLN-----------------GV--ENYDVH------------V-----F--PD-------------S------------------------------------DHSIRY-HNANVIVFDKLLDWA-KRAF------------------------------------------1107
1108 ------------------------------------------PPH------FNP-A--------RK-YP-----V-LFH----L-------Y---------------------------------------------------------G--------------------GP--------------------------------GSQTVDRRFNV-D----FQS----YVAA--SL----------------GYI-----V----------------------------------------VT------V-D---GR-GT--------------GF------IGRAARCIIRGNIG-----------HYEAID--QIAT----------------------------------------------A-----------------------------K--NWAQ----------------------------------------K-PY---V-------DES--------------------------------------------------------R----M-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MTLKTLE-----Q--------------DA--------------GE-TFQY----------------------------------------------G--MAV------------------------------------------A-----PVTDWRFY----------------DSVYTERYMHTP--QHNPTG-----------------------------------------YDNTSI---------------------------------------------------------------------------------------------------------------------------------------------------------S--D-M-----------------------------------------------AALHN--NV--------------------------R-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI-H-----GASDD--NVHI-QNTL-----------TLI-DK-L-----DLA-----------------SV--QNYDVH------------F-----Y--PD-------------S------------------------------------DHSIFF-HNAHTMVYERLASWL-VNAFN-----------------------------------------1108
1109 ------------------------------------AMET-LPLN------FDK-T--------KK-YP-----V-LFY----I-------Y---------------------------------------------------------G--------------------GP--------------------------------GSQTVTKKWAL-S----FSS----LIAA--EL----------------DAV-----V----------------------------------------VT------I-D---GR-GT--------------GFNNLNYKLGSKFKFIVRDRLG-----------QYEPID--VISA----------------------------------------------A-----------------------------N--KWAE----------------------------------------K-SY---V-------DPE--------------------------------------------------------R----I-AV--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTLKTLE-----T--------------DI--------------DNPIFNY----------------------------------------------A--VAI------------------------------------------A-----PVTRWRLY----------------DSIYTERYLNTP--QENPKG-----------------------------------------YETGSI---------------------------------------------------------------------------------------------------------------------------------------------------------H--N-V-----------------------------------------------TNFKH--VK--------------------------K-------------------------FF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IG-H-----GSGDD--NVHV-QNSL-----------QLL-DE-F-----NLA-----------------EV--ENFEFM------------I-----F--PD-------------S------------------------------------NHG------------------------------------------------------------------1109
1110 --------LRNYVVPEVKYSQVELDDKETGQPFLVTAMET-LPLN------FDK-T--------KK-YP-----V-LFY----I-------Y---------------------------------------------------------G--------------------GP--------------------------------GSQTVTKKWAL-S----FSS----LIAA--EL----------------DAI-----V----------------------------------------VT------I-D---GR-GT--------------GFNNLNYKLGSKFKFIVRDRLG-----------QYEPID--VISA----------------------------------------------A-----------------------------N--KWAE----------------------------------------K-SY---V-------DPE--------------------------------------------------------R----I-AV--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTLKTLE-----T--------------DI--------------DNPIFNY----------------------------------------------A--VAI------------------------------------------A-----PVTRWRLY----------------DSIYTERYLNTP--QENPKG-----------------------------------------YETGSI---------------------------------------------------------------------------------------------------------------------------------------------------------H--N-V-----------------------------------------------TNFKH--VK--------------------------K-------------------------FF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IG-H-----GSGDD--NVHV-QNSL-----------QLL-DE-F-----NLA-----------------EV--ENFEFM------------I-----F--PD-------------S------------------------------------NHGMNY-HNGFNVVYDRILDFF-KRAF------------------------------------------1110
1111 -----------------------------------------LPVG------FSP---------DKK-YP-----V-LFT----P-------Y---------------------------------------------------------G--------------------GP--------------------------------GAQEVSKRWQS-L--D-FNA----YIASDPEL----------------EYV-----T----------------------------------------WT------V-D---NR-GT--------------GY------RGREFRSLVAKQLG-----------KLEAED--QVYA----------------------------------------------A-----------------------------K--QAAK----------------------------------------L-DW---V-------DSE--------------------------------------------------------H----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LTGKVLE-----T--------------DS--------------G--AFSL----------------------------------------------G--LLT------------------------------------------A-----PVSDWRLY----------------DSMYTERYMKTL--STNAEG-----------------------------------------YNTTAI---------------------------------------------------------------------------------------------------------------------------------------------------------R--H-T-----------------------------------------------DGFKNVE-G--------------------------G-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IQ-H-----GTGDD--NVHF-QNAA-----------ALG-DT-L-----IGN-----------------GVTPEKMQVQ------------W-----F--TD-------------S------------------------------------DHSIRY-NGGNVFLYRQLAQRLYK---------------------------------------------1111
1112 -----------------------------------------LPPG------FSP---------DKK-YP-----I-LFT----P-------Y---------------------------------------------------------G--------------------GP--------------------------------GAQEVTKRWQA-L--N-FKA----YVASDSEL----------------EYV-----T----------------------------------------WT------V-D---NR-GT--------------GF------KGRKFRSAVTRQLG-----------LLEAED--QIYA----------------------------------------------A-----------------------------Q--QAAN----------------------------------------I-PW---I-------DAD--------------------------------------------------------H----I-GI--W-G--WS-----------------FG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LTSKVLE-----K--------------DS--------------G--AFTL----------------------------------------------G--VIT------------------------------------------A-----PVSDWRFY----------------DSMYTERYMKTL--STNEEG-----------------------------------------YETSAV---------------------------------------------------------------------------------------------------------------------------------------------------------R--K-T-----------------------------------------------DGFKNVE-G--------------------------G-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IQ-H-----GTGDD--NVHF-QNSA-----------ALV-DL-L-----MGD-----------------GVSPEKLHSQ------------W-----F--TD-------------S------------------------------------DHGISY-HGGGVFLYKQLARKLYQ---------------------------------------------1112
1113 --------------------------------------IV-KPID------FDP---------SRH-YP-----V-LMV----Q-------Y---------------------------------------------------------S--------------------GP--------------------------------NSQQVLDRYSF-D----WEH----YLAS---K----------------GYV-----V----------------------------------------AC------V-D---GR-GT--------------GA------RGEEWRKCTYMQLG-----------VFESDD--QIAA----------------------------------------------A-----------------------------T--AIGQ----------------------------------------L-PY---V-------DAA--------------------------------------------------------R----I-GI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-TTLMSLC-----R--------------GN--------------G--TFKA----------------------------------------------G--IAV------------------------------------------A-----PVADWRFY----------------DSVYTERFMRTP--KENASG-----------------------------------------YKMSSA---------------------------------------------------------------------------------------------------------------------------------------------------------L--DVA-----------------------------------------------SQLQG------------------------------N-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-S-----GSADD--NVHL-QNTM-----------LFT-EA-L-----VQA-----------------NI---PFDMA------------I-----Y--MD-------------K------------------------------------NHSIYG-GNTRYHLYTRKAKFL-----------------------------------------------1113
1114 ------------RLKAYRYNPKEFTIIKTQSGLELNAWIV-KPID------FDP---------SRH-YP-----V-LMV----Q-------Y---------------------------------------------------------S--------------------GP--------------------------------NSQQVLDRYSF-D----WEH----YLAS---K----------------GYV-----V----------------------------------------AC------V-D---GR-GT--------------GA------RGEEWRKCTYMQLG-----------VFESDD--QIAA----------------------------------------------A-----------------------------T--AIGQ----------------------------------------L-PY---V-------DAA--------------------------------------------------------R----I-GI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-TTLMSLC-----R--------------GN--------------G--TFKA----------------------------------------------G--IAV------------------------------------------A-----PVADWRFY----------------DSVYTERFMRTP--KENASG-----------------------------------------YKMSSA---------------------------------------------------------------------------------------------------------------------------------------------------------L--DVA-----------------------------------------------SQLQG------------------------------N-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-S-----GSADD--NVHL-QNTM-----------LFT-EA-L-----VQA-----------------NI---PFDMA------------I-----Y--MD-------------K------------------------------------NHSIYG-GNTRYHLYTRKAKFLFDNL-------------------------------------------1114
1115 ------------TLAGYAIPQKEFFTFQTTDGVTLNGWMM-KPVN------FSA---------SKK-YP-----V-LMY----Q-------Y---------------------------------------------------------S--------------------GP--------------------------------GSQQVLDTWGI-S----WET----YMAS---L----------------GYI-----V----------------------------------------VC------V-D---GR-GT--------------GG------RGEAFEKCTYLKIG-----------VKEAKD--QVET----------------------------------------------A-----------------------------L--YLGK----------------------------------------Q-PY---V-------DKD--------------------------------------------------------R----I-GI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTLMSMS-----E--------------GT--------------P--VFKA----------------------------------------------G--VAV------------------------------------------A-----APTDWRFY----------------DTIYTERFMRTP--KENAEG-----------------------------------------YKESSA---------------------------------------------------------------------------------------------------------------------------------------------------------F--TRA-----------------------------------------------DKLHG------------------------------N-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----GMADD--NVHF-QNCA-----------EYA-EH-L-----VQL-----------------GK---QFDMQ------------V-----Y--TN-------------R------------------------------------NHGIYG-GNTRQHLYTRLTNF------------------------------------------------1115
1116 ------------------------FTFQTTDGVTLNGWMM-KPVN------FSA---------SKK-YP-----V-LMY----Q-------Y---------------------------------------------------------S--------------------GP--------------------------------GSQQVLDTWGI-S----WET----YMAS---L----------------GYI-----V----------------------------------------VC------V-D---GR-GT--------------GG------RGEAFEKCTYLKIG-----------VKEAKD--QVET----------------------------------------------A-----------------------------L--YLGK----------------------------------------Q-PY---V-------DKD--------------------------------------------------------R----I-GI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTLMSMS-----E--------------GT--------------P--VFKA----------------------------------------------G--VAV------------------------------------------A-----APTDWRFY----------------DTIYTERFMRTP--KENAEG-----------------------------------------YKESSA---------------------------------------------------------------------------------------------------------------------------------------------------------F--TRA-----------------------------------------------DKLHG------------------------------N-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----GMADD--NVHF-QNCA-----------EYA-EH-L-----VQL-----------------GK---QFDMQ------------V-----Y--TN-------------R------------------------------------NHGIYG-GNTRQHLYTRLTNF------------------------------------------------1116
1117 -------------------------------------WMI-KPKN------FDP-A--------KK-YP-----V-FMF----Q-------Y---------------------------------------------------------S--------------------GP--------------------------------GSQQVANSWDG-GNGI-WFD----ML-A--QK----------------GYL-----V----------------------------------------VC------V-D---GR-GT--------------GF------RGTKYKKVTYKNLG-----------KYEIED--QITA----------------------------------------------A-----------------------------K--WLGN----------------------------------------Q-SY---V-------DKS--------------------------------------------------------R----I-GI--F-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MASLAMT-----K--------------GA--------------D--VFKM----------------------------------------------G--IAV------------------------------------------A-----PVTNWRFY----------------DSIYTERFLQTP--QENKDG-----------------------------------------YD---L---------------------------------------------------------------------------------------------------------------------------------------------------------N--S-P-----------------------------------------------TTYAKLLKG--------------------------K-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QNSM-----------EFS-EA-L-----IQN-----------------K---KQFDFM------------A-----Y--PD-------------K------------------------------------NHSIIG-GNTRPQLYEKMTNYI-----------------------------------------------1117
1118 --------------------------------------ML-KPEG------FDP---------SKK-YP-----L-VMT----Q-------Y---------------------------------------------------------S--------------------GP--------------------------------GSQTVKNCFSF-G----WEE----YLAQ---E----------------GFV-----V----------------------------------------VA------V-D---GR-GT--------------GG------RGSEFKKCTYLQMG-----------ILETQD--QIEA----------------------------------------------A-----------------------------Q--ALGQ----------------------------------------L-PY---I-------DAK--------------------------------------------------------R----I-GI--Y-G--WS-----------------FG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTLMTMT-----R--------------GQ--------------G--TFAA----------------------------------------------G--VAV------------------------------------------A-----PPTDWGLY----------------DSIYTERYMRTP--QENAKG-----------------------------------------YQATSV---------------------------------------------------------------------------------------------------------------------------------------------------------M--PYV-----------------------------------------------SGLKG------------------------------D-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-Q-----GTADD--NVHM-QNVM-----------HLV-PA-L-----VEA-----------------DK---DYRML------------V-----Y--TD-------------K------------------------------------NHSIYG-GNTRNHLFRQITNHFKNSL-------------------------------------------1118
1119 --------LKGVALPSHKILTVDIDGGF------QAKVLLQLPPN------LDT-SG------ATK-YP-----M-LVD----V-------Y---------------------------------------------------------G--------------------GP--------------------------------DSYSVTNKWMV-D----WGT----YLSS--NQ----------------SVI-----Y----------------------------------------AK------I-D---GR-GS--------------GL------RGESLLHAIYLKLG-----------TVEISD--QINV----------------------------------------------T-----------------------------Q--KLSTL---------------------------------------F-NY---I-------DPD--------------------------------------------------------H----V-GI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-AAAMALA-----N--------------DE-------------AK--VFKC----------------------------------------------A--ASI------------------------------------------A-----PVTDWAYY----------------DSIYTERYMGLP--NTNELG-----------------------------------------YANSRL---------------------------------------------------------------------------------------------------------------------------------------------------------S--TMA-----------------------------------------------VKLRGKK------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----GTLDD--NVHY-QQAM-----------ILA-KN-L-----ERQ-----------------DI---LFKQI------------S-----Y--AD-------------E------------------------------------DHGL---SNVRPHLYHSLDRFF-GECFA-----------------------------------------1119
1120 --------LKGVALPSHKILTVDIDGGF------QAKVLLQLPPN------LDT-SG------ATK-YP-----M-LVD----V-------Y---------------------------------------------------------G--------------------GP--------------------------------DSYSVTNKWMV-D----WGT----YLSS--NQ----------------SVI-----Y----------------------------------------AK------I-D---GR-GS--------------GL------RGESLLHAIYLKLG-----------TVEISD--QINV----------------------------------------------T-----------------------------Q--KLSTL---------------------------------------F-NY---I-------DPD--------------------------------------------------------H----V-GI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-AAAMALA-----N--------------DE-------------AK--VFKC----------------------------------------------A--ASI------------------------------------------A-----PVTDWAYY----------------DSIYTERYMGLP--NTNELG-----------------------------------------YANSRL---------------------------------------------------------------------------------------------------------------------------------------------------------S--TMA-----------------------------------------------VKLRGKK------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----GTLDD--NVHY-QQAM-----------ILA-KN-L-----ERQ-----------------DI---LFKQI------------S-----Y--AD-------------E------------------------------------DHGL---SNVRPHLYHSLDRFF-GECFA-----------------------------------------1120
1121 --------LKGKAIPRVEIHELDLGNGF------TAKAMLLIPPG------TNTSSS------AIK-HP-----M-LVD----V-------Y---------------------------------------------------------G--------------------GP--------------------------------NSANVVGTWSI-G----WGT----HLAS--NR----------------SVV-----Y----------------------------------------AK------I-D---GR-GS--------------GL------RGDRLMYQIYRKLG-----------TVEVQD--QITG----------------------------------------------A-----------------------------R--KLAEQ---------------------------------------L-PF---V-------DPQ--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-ASAMALA-----Q--------------DT-------------QH--VFQC----------------------------------------------A--VSV------------------------------------------A-----PVTDWLFY----------------DSIYTERYMGLPTLTDNRAG-----------------------------------------YETSRL---------------------------------------------------------------------------------------------------------------------------------------------------------T--ALH-----------------------------------------------ERFRNRT------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----GTYDD--NVHY-QQAM-----------QLA-RA-L-----ETH-----------------DI---MFKQV------------S-----Y--PD-------------E------------------------------------DHSL---AGVRPHLYHTLGKFF-SECL------------------------------------------1121
1122 --------------------------------------KLLLPPS------LNR-NR------ASQ-YP-----M-LVY----V-------Y---------------------------------------------------------G--------------------GP--------------------------------SSQQVSDRYRV-D----WGY----HLST--SR----------------GVI-----Y----------------------------------------AL------I-D---GR-GS--------------GF------QGDKMLHEIYRRMG-----------TVEIQD--QIKV----------------------------------------------A-----------------------------K--FLKEN---------------------------------------L-PF---V-------DGN--------------------------------------------------------K----T-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-ATASALA-----Q--------------DT-------------EG--VFKC----------------------------------------------G--MSV------------------------------------------A-----PVTNWIYY----------------DSIYTERYMGLPTAEDNLKA-----------------------------------------YDDGDV---------------------------------------------------------------------------------------------------------------------------------------------------------C--KYP-----------------------------------------------ENFRGKQ------------------------------------------------------FY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHY-QQSL-----------QLA-KS-L-----EGA-----------------DV---LFRQQ------------S-----Y--TD-------------E------------------------------------NHSI---NTFKKHLYHSLGTFLMTDCFDI----------------------------------------1122
1123 --------LKRKAVPTKKYLEIPIEGYI------MNAQLT-LPAN------MDN---------ARK-HA-----L-LVD----V-------Y---------------------------------------------------------G--------------------GP--------------------------------GSQKVQETFQL-G----WPA----YLAS--QY----------------NVI-----V----------------------------------------AS------I-D---GR-GA--------------GN------YGDNYLFELYKKFG-----------TVEIED--QMQG----------------------------------------------A-----------------------------E--Y-IKE---------------------------------------L-SY---I-------DSN--------------------------------------------------------K----A-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-ASAMALA-----T--------------G---------------E--TFNC----------------------------------------------A--MSV------------------------------------------S-----PVTDWRYY----------------DSAYTERYMGFP--SDNLQG-----------------------------------------YLASNV---------------------------------------------------------------------------------------------------------------------------------------------------------S--SLA-----------------------------------------------KNFIDKS------------------------------------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-H-----GLADD--NVHF-QNTA-----------NLI-KA-L-----THF-----------------EV---DYEVQ------------F-----Y--TD-------------K------------------------------------AHDLAG-LHTRRHLYRLLTKHL-IQCLNL----------------------------------------1123
1124 -------------------------------------ELL-IPRA------LDI---------ARR-HP-----L-LVD----V-------Y---------------------------------------------------------G--------------------GP--------------------------------GSQQVDTKYHQ-G----WYS----YLSS--KH----------------HVI-----I----------------------------------------AR------I-D---GR-GS--------------GY------KGQKMLYEINKRLG-----------TVEIED--QITA----------------------------------------------T-----------------------------E--YLLDN---------------------------------------F-RY---L-------DWN--------------------------------------------------------K----T-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-AATLA-A-----T--------------H---------------G--IYNC----------------------------------------------T--MAV------------------------------------------A-----PVTDWRFY----------------DSVYTERYMGLPKATDNLQA-----------------------------------------YKNSNI---------------------------------------------------------------------------------------------------------------------------------------------------------S--AVA-----------------------------------------------SGLHKTK------------------------------------------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----GLADD--NVHF-QNSA-----------NLV-KA-L-----VQE-----------------GV---SHQVQ------------Y-----Y--TD-------------Q------------------------------------NHALAD-PMVQQDLYHILTDFL-VHSFGL----------------------------------------1124
1125 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHAVYKNLG-----------HYETID--ALNL----------------------------------------------A-----------------------------K--YLRK----------------------------------------Q-TY---I-------HPD--------------------------------------------------------R----I-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-YAASVLA-----D--------------SN--------------G--LINT----------------------------------------------A--VSV------------------------------------------A-----PVTDWRYY----------------DTVYTERYMGLPFAEENLKG-----------------------------------------YESTSL---------------------------------------------------------------------------------------------------------------------------------------------------------L--TKV-----------------------------------------------SNFTGKN------------------------------------------------------FF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QNSA-----------QLV-TA-L-----IRE-----------------KI---KFQSQ------------Y-----F--PD-------------L------------------------------------DHSISS---------------------------------------------------------------1125
1126 --------------------------------------------P------YDF-DP------KRK-YA-----V-LFD----V-------Y---------------------------------------------------------G--------------------GP--------------------------------NTQKVDDIFTI-E----F-P----IIFP--SY----------------NII-----L----------------------------------------VN------F-D---AR-GS--------------GY------RGYKFLHAVYKRLG-----------YYETID--AVNV----------------------------------------------A-----------------------------K--YLKK----------------------------------------Q-SY---V-------DPN--------------------------------------------------------R----F-AI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-YAATVLA-----D--------------SH--------------G--VINT----------------------------------------------A--VSV------------------------------------------A-----PVTDWRYY----------------DTVYSERYMGLPTLADDLKG-----------------------------------------YEETAL---------------------------------------------------------------------------------------------------------------------------------------------------------M--SKA-----------------------------------------------SRFKDKN------------------------------------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHF-QNSA-----------QLA-AA-L-----VKE-----------------KV---KFTTQ------------F-----F--TE-------------K------------------------------------DHNIDS-GDYVYT--------------------------------------------------------1126
1127 -----------------RFLRVPVGDDG----QFEASVRLFLPPE------IDFEEAAAGTATTRK-YP-----M-VVN----V-------Y---------------------------------------------------------A--------------------GP--------------------------------DSVRVTDSFS--G----FAN----YMAT--TK----------------GVI-----Y----------------------------------------AQ------I-D---GR-GT--------------GN------QGYEFLFSINNRLG-----------TYEMED--QIAV----------------------------------------------A-----------------------------R--YLQER---------------------------------------Y-AF---I-------DPE--------------------------------------------------------R----T-GI--W-G--SS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-ATAMTLE-----K--------------DH-------------EQ--VYRC----------------------------------------------G--ISV------------------------------------------A-----PVTSWMFY----------------DSIYTERYMGRPT--DNGAG-----------------------------------------YDRSDI---------------------------------------------------------------------------------------------------------------------------------------------------------S--SFT-----------------------------------------------DELKNHL------------------------------------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GTADD--NVHY-QQSM-----------VFV-RA-L-----LDH-----------------DI---DFEQM------------S-----Y--PD-------------E------------------------------------AHSL---SGVQRHLYHTMDQFW-DRCFA-----------------------------------------1127
1128 --------------PSYRFMNVTLADGS----IGYA--KLALPP--------NFVE-------TKK-YP-----L-IVV----V-------Y---------------------------------------------------------Q--------------------GP--------------------------------NSVRVTNGFTL-G----YEA----FVTT--SR----------------DTI-----Y----------------------------------------AY------I-D---GR-GT--------------GN------KGKDLLFSVNNDLG-----------DHEVED--QLFV----------------------------------------------T-----------------------------R--WMQQN---------------------------------------L-AF---V-------DAE--------------------------------------------------------R----C-GI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTAKTIE-----K--------------DD-------------DR--VFQC----------------------------------------------G--VSV------------------------------------------A-----PVTSWLYY----------------DTIYTERYMGLPTDDDNLKK-----------------------------------------YNESSV---------------------------------------------------------------------------------------------------------------------------------------------------------F--GNL-----------------------------------------------ENFKSHD------------------------------------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GSGDD--NVHY-QHSL-----------LLA-KL-L-----QRQ-----------------DI---QFEEQ------------T-----Y--TD-------------E------------------------------------NHGI---GNALPHLYHTIDAFW-TNCLNL----------------------------------------1128
1129 --------------------------------------RLYLPPV------LRE-DE------ITR-YP-----T-ILH----V-------Y---------------------------------------------------------S--------------------GP--------------------------------GSQLVTDHWHV-D----WNT----YLSG--SK----------------DYI-----V----------------------------------------VE------I-D---GR-GS--------------AG------QGYQLLHEVYKRLG-----------SVEVSD--QLEV----------------------------------------------S-----------------------------E--YLRDN---------------------------------------L-HF---I-------DSR--------------------------------------------------------R----M-GV--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-TAALALA-----G--------------QQ--------------S--IFQC----------------------------------------------G--ISV------------------------------------------S-----PVTNWKLY----------------DSTYAERYLSFPNVTDNYKG-----------------------------------------YEESDL---------------------------------------------------------------------------------------------------------------------------------------------------------S--KYV-----------------------------------------------DNLRDRQ------------------------------------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----GTADD--NVHV-QQSM-----------VLA-RS-L-----TSK-----------------GV---LYKQQ------------I-----Y--PD-------------E------------------------------------GHSL---SGVKRHLYRSMTAFF-EDCF------------------------------------------1129
1130 --------MAKTAMPQIKTFPVMISGGY------HAQVRLYLPPV------LRE-DE------ITR-YP-----T-ILH----V-------Y---------------------------------------------------------S--------------------GP--------------------------------GSQLVTDHWHV-D----WNT----YLSG--SK----------------DYI-----V----------------------------------------VE------I-D---GR-GS--------------AG------QGYQLLHEVYKRLG-----------SVEVSD--QLEV----------------------------------------------S-----------------------------E--YLRDN---------------------------------------L-HF---I-------DSR--------------------------------------------------------R----M-GV--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-TAALALA-----G--------------QQ--------------S--IFQC----------------------------------------------G--ISV------------------------------------------S-----PVTNWKLY----------------DSTYAERYLSFPNVTDNYKG-----------------------------------------YEESDL---------------------------------------------------------------------------------------------------------------------------------------------------------S--KYV-----------------------------------------------DNLRDRQ------------------------------------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----GTADD--NVHV-QQSM-----------VLA-RS-L-----TSK-----------------GV---LYKQQ------------I-----Y--PD-------------E------------------------------------GHSL---SGVKRHLYRSMTAFF-EDCF------------------------------------------1130
1131 --------INKVALPQVKSFPVMISGGY------HAQVRLFLPPG------LRE-DE------ITR-YP-----M-IVH----V-------Y---------------------------------------------------------S--------------------GP--------------------------------GTQLVTDKWRV-D----WNT----YLAG--TK----------------DYI-----V----------------------------------------TQ------I-D---GR-GS--------------SG------QGYQLLHEVYRRLG-----------TVEVSD--QLEV----------------------------------------------A-----------------------------E--YLRDS---------------------------------------L-HF---V-------DKR--------------------------------------------------------R----V-GI--W-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-TAALAMA-----S--------------PT--------------S--LFQC----------------------------------------------G--ISV------------------------------------------A-----PVTNWKLY----------------DSTYTERYMGMPNVTDNYKG-----------------------------------------YEDSDL---------------------------------------------------------------------------------------------------------------------------------------------------------S--KHA-----------------------------------------------EKLRDKQ------------------------------------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MV-H-----GTADD--NVHF-QQSM-----------VFS-KA-L-----SSK-----------------GA---LFKQL------------I-----Y--PD-------------E------------------------------------GHNL---AGVKKHLYRSMTLFL-EDCF------------------------------------------1131
1132 -------------------------------NQIDVEAKLYLPPE------LDPAH-------ITQ-YP-----L-LLY----A-------Y---------------------------------------------------------G--------------------GP--------------------------------TFQVVTSAFTI-D----WLT----YISA--TA----------------KVI-----V----------------------------------------AQ------V-D---GR-GT--------------GG------RGRLYEQSIYKNLG-----------VIEIED--QLDS----------------------------------------------V-----------------------------K--ALIRR---------------------------------------Y-HY---I-------NES--------------------------------------------------------Q----V-GA--Y-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-TVSHLLT-----R--------------PE-------------NQ--WIRC----------------------------------------------G--ISV------------------------------------------A-----PVSDFRYY----------------TTAYSERYLGRF--IDDPDA-----------------------------------------YSRTAI---------------------------------------------------------------------------------------------------------------------------------------------------------R-----------------------------------------------------NPKNMASK--------------------------G-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-H-----GTADD--NVHL-VNTA-----------KLI-KE-L-----VAA-----------------GV---DLDLM------------I-----Y--PD-------------D------------------------------------DHFLSK-GRNLESLYRKMTIFL-LDCYN-----------------------------------------1132
1133 ------------RLPTREFIRVDLGEGF------SGYGVISYPPD------IDD---------DEE-VP-----L-FVD----V-------Y---------------------------------------------------------A--------------------GP--------------------------------GTQQVSKRFNMGGTSSNWKA----YLGS--TH----------------RIA-----V----------------------------------------AS------L-D---GR-GM--------------SG------VSEETKFMVYKNLG-----------DVEIRD--QILG----------------------------------------------G-----------------------------E--FMRNL---------------------------------------P-SI---S-------DEL--------------------------------------------------------P----A-GI--W-G--SS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-VTSHVIS-----R--------------NE--------------EDNPFRC----------------------------------------------G--IAF------------------------------------------A-----PVTNFLAY----------------DTAYTERYMSLASTDDNNEG-----------------------------------------YLKTDV---------------------------------------------------------------------------------------------------------------------------------------------------------S--RMA-----------------------------------------------SNFEGRQ------------------------------------------------------FF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LA-H-----GTADD--NVHY-WHAA-----------QLN-RK-L-----SAA-----------------EV---PFRQM------------T-----L--ID-------------M------------------------------------AHGVG--SSISRHYYATLTDFLSR---------------------------------------------1133
1134 ------------------------------------------PPL------FDA---------NKR-YP-----V-MLY----V-------Y---------------------------------------------------------G--------------------GP--------------------------------GSQTVKTSWSL-G----FPQ----YFST--TL----------------QMV-----V----------------------------------------IR------V-D---PR-GT--------------GY------RGNRFKFLTYRKIG-----------LLESDD--FLNV----------------------------------------------F-----------------------------R--YLRQQ-----------------------------------------SY---V-------DPD--------------------------------------------------------K----I-CM--F-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTAMVTG-----R--------------NQ--------------G--LFKI----------------------------------------------G--FSV------------------------------------------A-----PVANWGFY-----------------------------------G-----------------------------------------FKNKTV---------------------------------------------------------------------------------------------------------------------------------------------------------S-----------------------------------------------------------------------------------------------------------------FF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IA-H-----GTSDD--NVHY-SNTA-----------ILV-EA-L-----QNE-----------------VI---PFRMQ------------A-----Y--TN-------------K------------------------------------DHSIR--GGANKHLVLQMTDMITKSFGI-----------------------------------------1134
1135 --------LKDITLPKREIMEFERDGYK-------MNTFIYYPPG------FDK---------DKQ-YP-----V-LMY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFMYSTYLRMG-----------VQEAED--IIAF----------------------------------------------A-----------------------------K--YIKTF-----------------------------------------RY---V-------HKS--------------------------------------------------------K----V-GI--F-G--WS-----------------HG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LGGMAMG-----I--------------ND--------------H--VFSL----------------------------------------------G--LLV------------------------------------------A-----PVSDFRFY----------------DTGYTERFMLSP--KENLKG-----------------------------------------YEEASI---------------------------------------------------------------------------------------------------------------------------------------------------------L--NRL-----------------------------------------------DGFKNAT------------------------------------------------------VF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IA-H-----GNADD--NVHF-QNSA-----------VLV-QS-L-----QEK-----------------GI---QFRMM------------M-----Y--PN-------------K------------------------------------NHNID--GYGRKHLFVAMTNLIAEKFVL-----------------------------------------1135
1136 ---------------------PSVFFKVIKVKNITAYIQEIRPPN------FNP---------RKR-YP-----T-VFH----L-------Y---------------------------------------------------------G--------------------AP--------------------------------QSALVTGKYEM-D----INE----LMAS--VY----------------NFL-----V----------------------------------------IK------V-D---IV-DI--------------SD-----VSGQHLFSDSHELI---------------IKS--WIEL----------------------------------------------L-----------------------------R--SYVDT-----------------------------------------PY---I-------DRH--------------------------------------------------------R----V-GI--W-G--WS-----------------FG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LTLKILE-----N--------------AD-----------------FIKT----------------------------------------------G--AVV------------------------------------------A-----PVTDWRYY----------------DAYYSENLLGAYSKQTTAI------------------------------------------YDKTAV------------------------------------------------------------------------------------------------------------------------------------------------------------HYS-----------------------------------------------ENFRKLC----------------------------G-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VL-H-----GTSDD--NVHI-ENTM-----------QLT-KA-M-----VEK-----------------GV--YNYYPF------------I-----V--PN-------------A------------------------------------NHEFSD-PTDYTFLREKLSGHF-----------------------------------------------1136
1137 -------------------------------DGTRIDGLLTLP---VNKSEAK----------P---YP-----L-LVF----I-------H---------------------------------------------------------G--------------------G---------PQGQ--------------------------------------------DAHEFNTIPQLF--------AAR-GWA-----V----------------------------------------LN------V-N---YR--G----SN---------------GRGLAFQRAIWANWG-------V----LEVQD--VQAC----------------------------------------------V-----------------------------H--KVIQE-----------------------------------------GI---A-------DPN--------------------------------------------------------R----M-GV--G-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------I-MTD------------------------------------------FMIAS------------------------TNE--FKAASSGAGTGDPLALYG--VDE------------------------------------------Y-----G--NQYN-----------------F------------------------------------------------------------ELGEP----------------------W----------------------------------KDL---NTYIKIG------------------------YP----F--FH-------------------------------------------------A--DRI-HT--------------------------------------------P------------------------------------------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FM-G-----GTSDF--NVPV-VAGE-----------QMY-LA-L-----QTL-----------------HV-------P-------------SALIVY--PQ-------------Q------------------------------------FHGFTDP-----TYIRDRYQYWFNW--------------------------------------------1137
1138 ---------------------------------TTLYGTLMLPEG------KTA---------AHS-VP-----L-IVN----P-------Y---------------------------------------------------------G--------------------GP--------------------------------DVGEATDRWGG-RHLF-WNE-----LLA--QH----------------GFA-----V----------------------------------------LT------M-D---NR-GM--------------GA------RGRAFEQACYHNFG-----------PPELAD--QLAS----------------------------------------------V-----------------------------D--QVLKK---------------------------------------Y-PQ---L-------DPH--------------------------------------------------------R----L-GW--W-G--WS-----------------WG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-FTLYALS-----H--------------SD-----------------RFRV----------------------------------------------G--VAV------------------------------------------A-----PVTSWRNY----------------DSIYTERYMGLP--SEDAHA-----------------------------------------YEVDSV---------------------------------------------------------------------------------------------------------------------------------------------------------Q--NSV-----------------------------------------------AHLH----G--------------------------H-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LM-H-----GTGDD--NVHF-ANTI-----------QYI-QK-L-----IEA-----------------GV---PYDYN------------V-----F--PR-------------K------------------------------------THSIAG-ALDQTELYNRI---------------------------------------------------1138
1139 -------------LANKYRPTVELGSLKTAEG-DELYYKLTRPAE------LEP---------GRK-YP-----V-VLY----V-------Y---------------------------------------------------------G--------------------GP--------------------------------HSQLVTDSWRA-LRMG-WDT----FMA---QE----------------GYI-----V----------------------------------------FT------L-D---NR-GT--------------AN------RGMAFESITHRQLG-----------KVEMAD--QMLG----------------------------------------------I-----------------------------D--YLRSL-----------------------------------------PY---V-------DAD--------------------------------------------------------R----I-GV--Y-G--WS-----------------FG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MATNLML-----S--------------HP--------------E--TFKV----------------------------------------------G--VAG------------------------------------------G-----PVMNWAYY----------------EVMYGERYMDTP--AENPEG-----------------------------------------YRENNL---------------------------------------------------------------------------------------------------------------------------------------------------------I----------------------------------------------------ERA-GDLKG--------------------------R-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GGIDP--VVLW-QHSQ-----------LFL-QA-S-----VKA-----------------GT---LPDYM------------V-----Y--PM-------------D------------------------------------EHNVR--GQDRVHLH------------------------------------------------------1139
1140 -------------DTGYAMPEIRTGTIMAADGQTPLYYKLTMPLH------FDP---------AKK-YP-----V-IVY----V-------Y---------------------------------------------------------G--------------------GP--------------------------------HAQLVTKTWRS-SVGG-WDI----YMA---QK----------------GYA-----V----------------------------------------FT------V-D---SR-GS--------------AN------RGAAFEQVIHRRLG-----------QTEMAD--QMCG----------------------------------------------V-----------------------------D--FLKKQ-----------------------------------------SW---V-------DAD--------------------------------------------------------R----I-GV--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MTTNLML-----T--------------YG--------------D--VFKV----------------------------------------------G--VAG------------------------------------------G-----PVIDWNRY----------------EIMYGERYFDAP--QENPEG-----------------------------------------YDAANL---------------------------------------------------------------------------------------------------------------------------------------------------------L----------------------------------------------------KRA-GDLKG--------------------------R-------------------------LM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GAIDP--VVVW-QHSL-----------LFL-DA-C-----VKA-----------------RT---YPDYY------------V-----Y--PS-------------H------------------------------------EHNV-----------------------------------------------------------------1140
1141 ------------------MPEIRTGTIMAADGQTPLYYKLTMPLH------FDP---------AKK-YP-----V-IVY----V-------Y---------------------------------------------------------G--------------------GP--------------------------------HAQLVTKTWRS-SVGG-WDI----YMA---QK----------------GYA-----V----------------------------------------FT------V-D---SR-GS--------------AN------RGAAFEQVIHRRLG-----------QTEMAD--QMCG----------------------------------------------V-----------------------------D--FLKSQ-----------------------------------------SW---V-------DAD--------------------------------------------------------R----I-GV--H-G--WS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MTTNLML-----T--------------HG--------------D--VFKV----------------------------------------------G--VAG------------------------------------------G-----PVIDWNRY----------------EIMYGERYFDAP--QENPEG-----------------------------------------YDAANL---------------------------------------------------------------------------------------------------------------------------------------------------------L----------------------------------------------------KRA-GDLKG--------------------------R-------------------------LM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GAIDP--VVVW-QHSL-----------LFL-DA-C-----VKA-----------------RT---YPDYY------------V-----Y--PS-------------H------------------------------------EHNVM--GPDRVHLYETITRY------------------------------------------------1141
1142 -------------YEGYEMPTIETGTIKADDGTTDLYYRLTKPAD------FDP---------NKK-YP-----V-IVY----V-------Y---------------------------------------------------------G--------------------GP--------------------------------HAQLVTGGWLN-GSRG-WDI----YMA---NK----------------GYI-----M----------------------------------------FT------L-D---NR-GS--------------AN------RGLEFENATFRRLG-----------IEEGKD--QVKG----------------------------------------------I-----------------------------E--FLKSL-----------------------------------------PY---I-------DGN--------------------------------------------------------R----I-GV--H-G--WS-----------------FG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-MTTALLL-----R--------------YP--------------E--IFKV----------------------------------------------G--VAG------------------------------------------G-----PVIDWGYY----------------EVMYGERYMDTP--ESNPEG-----------------------------------------YKECNL---------------------------------------------------------------------------------------------------------------------------------------------------------K----------------------------------------------------NLA-GQLKG--------------------------H-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-H-----DDHDD--TCVP-QHTL-----------SFM-KA-C-----VDA-----------------RT---YPDLF------------I-----Y--PC-------------H------------------------------------KHNVS--GRDRVHLHEKI---------------------------------------------------1142
1143 ------------------MPTIETGTIKADDGTTDLYYRLTKPAD------FDP---------NKK-YP-----V-IVY----V-------Y---------------------------------------------------------G--------------------GP--------------------------------HAQLVTGGWLN-GSRG-WDI----YMA---NK----------------GYI-----M----------------------------------------FT------L-D---NR-GS--------------AN------RGLEFENATFRRLG-----------IEEGKD--QVKG----------------------------------------------I-----------------------------E--FLKSL-----------------------------------------PY---I-------DGN--------------------------------------------------------R----I-GV--H-G--WS-----------------FG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-MTTALLL-----R--------------YP--------------E--IFKV----------------------------------------------G--VAG------------------------------------------G-----PVIDWGYY----------------EVMYGERYMDTP--ESNPEG-----------------------------------------YKECNL---------------------------------------------------------------------------------------------------------------------------------------------------------K----------------------------------------------------NLA-GQLKG--------------------------H-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------II-H-----DDHDD--TCVP-QHTL-----------SFM-KA-C-----VDA-----------------RT---YPDLF------------I-----Y--PC-------------H------------------------------------KHNVS--GRDRVHLHEKITRY------------------------------------------------1143
1144 ---------------------------------TPLHYSLIKPAG------FDP---------KKQ-YP-----V-VVF----V-------Y---------------------------------------------------------G--------------------GP--------------------------------AAQTVTRAWPG-RSDSFFNQ----YLA---QQ----------------GYV-----V----------------------------------------FT------L-D---NR-GT--------------PR------RGAAFGGALYGKQG-----------TVEVDD--QLRG----------------------------------------------I-----------------------------E--WLKSQ-----------------------------------------AF---V-------DPA--------------------------------------------------------R----I-GV--Y-G--WS-----------------NG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-MTLMLLA-----K--------------HD--------------E--AYAC----------------------------------------------G--VAG------------------------------------------A-----PVTDWALY----------------DTHYTERYMDLP--KANEAG-----------------------------------------YREASV---------------------------------------------------------------------------------------------------------------------------------------------------------F----------------------------------------------------THVDGIGAG--------------------------K-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GMADD--NVLF-TNST-----------KLM-SE-L-----QKR-----------------GT---PFELM------------T-----Y--PG-------------A------------------------------------KHGLR--GSDLLHRYRLTEDFFARCL-------------------------------------------1144
1145 ---------------------------------TELFGNVWKPIDF--DSTK-----------R---YP-----V-IAY----V-------Y---------------------------------------------------------P--------------------G---------PQTE----------------------------AV-TTGF------------SVRQPLLQL--------AQL-GFI-----V----------------------------------------VE------V-G---HR-GG----SP---------------QRSLAYHRFGYGNMR-----------DYALAD--KKSA----------------------------------------------I-----------------------------E--QLAAR-HAY------------------------------------------I-------DLD--------------------------------------------------------R----V-GI--F-G--HS-----------------GG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTA------------------------------------------AAMLL------------------------PPYNDFFKV-------------G--WSE------------------------------------------S-----GNHDNNI-----------------Y------------------------------------------------------------N------------------------QNW----------------------------------------------------SEWNHGV------------RV----VSKEDSARAARGGATAGSRGGPAGAGSAAREVAQDSTNYDGVRFDIRIPTNDELA--GNL-KG--------------------------------------------N------------------------------------------------------------LA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-T-----GDLDN--NVHP-GGTI-----------KLA-NA-L-----MRA-----------------NK-------R-------------FDYFVY--PG-------------E------------------------------------PH-------------------------------------------------------------------1145
1146 ----------------------------------DLYGLMWTPTKL--DSAR-----------K---YP-----I-INY----I-------Y---------------------------------------------------------P--------------------G---------PQGG----------------------------SVGSRQF-----------SAATRDNQAL--------AEL-GFI-----V----------------------------------------VA------I-D---GT--G----NP---------------MRSKSFHDAYYGRMG-----------DNTLPD--QIAG----------------------------------------------M-----------------------------K--ELASR-YRF------------------------------------------I-------DLD--------------------------------------------------------R----V-GM--W-G--HS-----------------GG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-ATA------------------------------------------GALFR------------------------YP--DFFKV-------------G--IAE------------------------------------------S-----GNHDNRN-----------------Y------------------------------------------------------------E------------------------DDW----------------------------------------------------GERYHGL---------LTRNG----ASDNYEAEA-----------------------------------------NQTLA--KNL-KG--------------------------------------------K------------------------------------------------------------LM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LA-H-----GTMDD--NVPP-DNTL-----------LVV-DA-L-----IKA-----------------GK-------D-------------FDLIMI--PN-------------A------------------------------------AHG------------------------------------------------------------------1146
1147 -----------------------RFTVKAADGMTDLYGVLIPPAST--NTKC-----------K---YP-----I-LDY----I-------Y---------------------------------------------------------G--------------------G---------PQLL----------------------------HT-PKEFIWGGEYSVEQPIDLVGGAQSF--------AQL-GFA-----V----------------------------------------IL------M-D---GR--G----TP---------------YRSKGFHDFSDGKLE-------W---SAGIED--HVVA----------------------------------------------I-----------------------------K--QLAEQ-YPF------------------------------------------L-------DSE--------------------------------------------------------K----V-GI--Y-G--ES-----------------GG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-AAA------------------------------------------RAILT------------------------YP--DVYKV-------------V--VSG------------------------------------------C-----GNHDQRL-----------------Y------------------------------------------------------------L------------------------AAW----------------------------------------------------GERFQGL-------------F----NSELYREQD-----------------------------------------NTRLV--KNL-NG--------------------------------------------K------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-T-----GDLDD--NVHP-ALTM-----------RMV-NA-L-----IKE-----------------NK-------D-------------FDLLIL--PN-------------R------------------------------------QHGISV---------------------------------------------------------------1147
1148 --------------IASGWQPPLSFHAKGRDGETDIWGVIHKPLNF--DRNK-----------R---YP-----V-VEN----I-------Y---------------------------------------------------------A--------------------G---------PTGS----------------------------FV-PKSF-----------SAL-V--EPL--------TQM-GFI-----V----------------------------------------VQ------I-D---GM--G----TN---------------NRSRAFHDIAWKNLK-----------DAGFPD--RILW----------------------------------------------H-----------------------------K--AASAK-YSW------------------------------------------Y-------DIS--------------------------------------------------------N----V-GI--F-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-NAV------------------------------------------SALLF------------------------HS--DFYKV-------------A--VAN------------------------------------------S-----GCYDNRM-----------------D------------------------------------------------------------K------------------------IWW----------------------------------------------------NEQWMGW-------------P----VGIEYSLSS-----------------------------------------AIDNA--HRL-QG--------------------------------------------K------------------------------------------------------------LM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-V-----GEMDR--NVDP-SSTF-----------QMA-DR-L-----IKA-----------------GK-------Y-------------FDMLVV--PS-------------A------------------------------------DHG------------------------------------------------------------------1148
1149 --------------------------------KTQIWGLIYKPLHF--DASK-----------K---YP-----V-VED----I-------Y---------------------------------------------------------A--------------------G---------PQGS----------------------------FV-PKSF-----------GPR-F--EPL--------TAL-GFV-----V----------------------------------------VQ------I-D---GM--G----TN---------------NRSKAFQDVIWKNLK-----------DSGFED--RILW----------------------------------------------H-----------------------------K--AVAAK-YRW------------------------------------------Y-------DIS--------------------------------------------------------H---GV-GI--F-G--TS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-STL------------------------------------------NALLF------------------------HP--EFYKA-------------G--VAN------------------------------------------S-----GCYDNRM-----------------D------------------------------------------------------------K------------------------IWW----------------------------------------------------NELWMGW-------------P----VGPQYAASS-----------------------------------------GVVNA--YRL-QG--------------------------------------------K------------------------------------------------------------LM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-M-----GGMDH--NVDP-SSTF-----------QVV-NA-L-----IHA-----------------GK-------D-------------FQLLVV--PN-------------G------------------------------------DHG------------------------------------------------------------------1149
1150 ---------------------------------TDIYGVVVRPVRF--DTRR-----------K---YP-----V-IEY----I-------Y---------------------------------------------------------A--------------------G---------PHGS----------------------------FV-PKNF-----------APH-YNMQSI--------ADL-GFI-----V----------------------------------------VQ------I-D---GM--G----TA---------------NRSRAFHDIAWKNLG-----------DAGFPD--RIRW----------------------------------------------H-----------------------------K--AFAAK-NPW------------------------------------------Y-------DIS--------------------------------------------------------R----V-GI--F-G--GS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-NAM------------------------------------------GALLF------------------------HP--EFYKV-------------A--VSF------------------------------------------A-----GCHDNRM-----------------D------------------------------------------------------------K------------------------IWW----------------------------------------------------NEQWMGY-------------P----IGPEYAASS-----------------------------------------NVVNA--HKL-QG--------------------------------------------E------------------------------------------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-V-----PELDT--NVDP-ASTM-----------QVV-NA-L-----IKA-----------------DK-------S-------------FDMLVM--PG-------------E------------------------------------DHG------------------------------------------------------------------1150
1151 --------------------------------KTDMWGIIIRPSNF--DPDK-----------K---YP-----V-LEY----I-------Y---------------------------------------------------------Q--------------------G---------PGNQ----------------------------YV-PKTF-----------IPYNYFMSGI--------AEL-GFI-----V----------------------------------------VM------V-D---GM--G----TS---------------FRSRTFENVCYKNLK-----------DAGLPD--HIAW----------------------------------------------I-----------------------------K--SAAQK-YPY------------------------------------------M-------DID--------------------------------------------------------R----V-GI--Y-G--CS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-ESM------------------------------------------TAVLF------------------------HP--EFYKA-------------A--YSA------------------------------------------C-----GCHDNRM-----------------D------------------------------------------------------------K------------------------IWW----------------------------------------------------NEQWLGY-------------P----VGEQYKEGS-----------------------------------------NVENA--HLL-SR--------------------------------------------P------------------------------------------------------------LM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-V-----GEMDD--NVDP-ASTM-----------QVA-NA-L-----IKA-----------------NK-------D-------------FELVVI--PG-------------A------------------------------------HH-------------------------------------------------------------------1151
1152 ---------------------------------DRQIVRLDLPARHGP-----------------------VPAL-HIV----P-------H---------------------------------------------------------G--------------------G---------------------------------------------------------------------------------SKT-----AVLVTH----GSGCDKTFYAWRLVDRL---IAHGAA-ALL---------I-D---LD-GHGESPRP-----------------------------------QAF---PHMVDS--VADP----------------------------------------------I-----------------------------D--WLRQR-YT--------------------------------------------------------------------------------------------------------------Q----V-GA--I-G--MS-----------------LG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVLAR---------------------------------------------------------------------------------------------A--VANGARVDALALWEVPP-----------RLRLDARAYRQVQIREAL-----AILQLRM-----------------L------------------------HLFRDGAVDHVI---------------------RA-WQTSGI-------------------------------------------------------------------------------RATISTWDLFDALAFP-------DS-------------------------------------------------L--RTL-----------------------------------------------ARREPPLP-----------------------------------------------------TL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-Y-----AGRDA--IVPP--AAA------------------A-----EVA-----------------------------------------ALAAG--WA-------------E------------------------------------YHLLPFASHISLPIDLECITLTVDW--------------------------------------------1152
1153 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------M----Q-----------------------------------------------------------------------------VIK-QK------LTAT-----------------CAQL-TG---YLHQPDT------N-A---HQ-TN-------------LPAIIIVPGGSYTHIP-----------VA-------QAES--LAMA----------------------------------------------F-----------------------------A--GHGYQ-------------------------------------------------------AFY----------------LEYTLLTDQQPLGLAPVLDLGRAVNLLRQHAAEWHIDPQQ----I-TP--A-G--FS-----------------VG-----------------------------G-HI------VALYNDYWATR-----VATELNVTPAMLKPNNVVLGYP---------------VISPLLGFPKDDATLATWTPTPN--------------------------------------------------------------------------------------------------------------E-LAA------------------------------------------------DQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVNSD----------------------------------------------------------NQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-------------------------------TF------------------------------------------------------IWTTA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDP--I----------------V--------------PATNTLAY---------ATA-LAT------------------------AKIP------YELH----------------------------------VFK--H-GPHG---------------------------------------------LALANAQTAWKPDANQPHVA-1153
1154 -----------------------------------------------------------------------------MF----L-------H---------------------------------------------------------G--------------------G-----------------------------------------------------------YWQAEQLSKDNNSLLGAPLVKNGAV-----L----------------------------------------VT------V-G---YS-LA----PE--------CTLHE------------------------------MVEQ--VKKA----------------------------------------------V-----------------------------V--FV-------------------------------------------------AK--RFP-DTR--------------------------------------------------------G----I-FI--S-G--HS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LAAMMLS-----V--------------DW-------------SSLL-----EGSKNVVKGILPMSGIYD-----------------VRP----------ITK------------------------------------------------------------------------------------------------------TYIN-------EP---MLL-------------------------------------------------------------------------------------------------------TESSASSVSP---------------------------------------------------------------------------------------------------------------L-------------L--LVDAI------PKCNLEVK-------------------------VH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IL-V-----AEYD-----PP----------------VLQIQA---------------------------QDYSK----------LLSSLGLDVETMTLPG-----------------K----------------------------------DHFEEMTDLSDENCPFQKVFLQ-----------------------------------------------1154
1155 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVEE--VKHS----------------------------------------------V-----------------------------M--FI-------------------------------------------------AN--KFP-DTR--------------------------------------------------------G----I-YV--C-G--HS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-LAAMLLT-----V--------------DW-------------TQ-Y-----DLLQNIIKGLLLVSGVFD-----------------LQP----------IVK------------------------------------------------------------------------------------------------------TYVN-------EP---LNL-------------------------------------------------------------------------------------------------------DEAEAIRLSP---------------------------------------------------------------------------------------------------------------L-----------------CHIKEACLHSKHC----K-------------------------VI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VS-V-----GEHD-----SP----------------SFRTQS---------------------------REYAK----------LLKDVGFDIKFKEVED-----------------K----------------------------------DHYNVVHDLVYDNYSLTQDFLK-----------------------------------------------1155
1156 ----------------------------------------------HVPYGDGEGENLDIYFPE----RVSEASPFCVF----F-------H---------------------------------------------------------G--------------------G-----------------------------------------------------------YWQS--GSKDTSAFMVNPLTAQGVA-----V----------------------------------------VI------V-A---YD-IA----PK--------GTLDQ------------------------------MVDQ--VTRS----------------------------------------------I-----------------------------V--YI-------------------------------------------------QK--QYP-RNE--------------------------------------------------------G----I-YL--C-G--HS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LAAMMLL-----A--------------DW-------------TK-H-----AVAPN-LRGFFLVSGIYD-----------------LEP----------IVF------------------------------------------------------------------------------------------------------TSQN-------GP---LLM-------------------------------------------------------------------------------------------------------TLEDARRNGP---------------------------------------------------------------------------------------------------------------Q-------------Q--LLEAALTQPVDPAC----H-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI-V-----GQHD-----SP----------------EFARQS---------------------------REFYQ----------TLCRGGWNASFEELHD-----------------V----------------------------------DHFEIIWKLTQDDYVLTQMILRT----------------------------------------------1156
1157 ----------------------------------------------HVSYGDGEGEKLDIYFPE----GVSEASPFCLF----F-------H---------------------------------------------------------G--------------------G-----------------------------------------------------------YWQS--GSKDTSAFMVNPLTEQGVT-----V----------------------------------------VV------V-A---YD-IA----PK--------GTLDQ------------------------------MVDQ--VTRS----------------------------------------------I-----------------------------V--FV-------------------------------------------------QK--QYP-CNE--------------------------------------------------------G----I-YL--C-G--HS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LAAMMLL-----A--------------NW-------------TK-H-----GVTPN-LKGFFLVSGIYD-----------------LKP----------IVY------------------------------------------------------------------------------------------------------TSQN-------AP---LLM-------------------------------------------------------------------------------------------------------TLEDAQRNSP---------------------------------------------------------------------------------------------------------------Q-------------L--LLEVALTRPLDPAC----H-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VS-V-----GQHD-----SP----------------EFHRQS---------------------------KEFYQVLPGLHLWPETLRQGGWNASFEEIHD-----------------M----------------------------------DHFEIIWNLTQKDYVLTQ---------------------------------------------------1157
1158 ----------------------------------------------HVPYGDRERERLDIYFPE----DESEALPFFVF----F-------H---------------------------------------------------------G--------------------G-----------------------------------------------------------YWQS--GSKDSSAFMVSPLTAQGVA-----V----------------------------------------VV------V-S---YD-IA----PK--------GTLDQ------------------------------MVDQ--VTQS----------------------------------------------I-----------------------------A--FV-------------------------------------------------QK--RYP-CNE--------------------------------------------------------G----I-YL--C-G--HS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LAAMMLL-----A--------------NW-------------TK-H-----GATPN-LKGFFLVSGIYD-----------------LEP----------IMH------------------------------------------------------------------------------------------------------IPEN-------EA---LLM-------------------------------------------------------------------------------------------------------TLEDAQRNSP---------------------------------------------------------------------------------------------------------------Q-------------R--CLEVALTQPVDAAC----P-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VI-V-----GQHD-----SP----------------EYHRQS---------------------------REFYQVSPTQ-----ALRRGGWKASFEELDD-----------------V----------------------------------DHFEIIWNLTQKDYVLTQ---------------------------------------------------1158
1159 ----------------------------------------------HVPYGDGEGEKVDIYFPD----ESSEALPFFLF----F-------H---------------------------------------------------------G--------------------G-----------------------------------------------------------YWQS--GSKDESAFMVHPLTAQGVA-----V----------------------------------------VI------V-A---YG-IA----PK--------GTLDH------------------------------MVDQ--VTRS----------------------------------------------V-----------------------------A--FV-------------------------------------------------QK--RYP-SNK--------------------------------------------------------G----I-YL--C-G--HS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LAAMMLL-----A--------------DW-------------TK-H-----GVTPN-LRGFFLVSGVFD-----------------LEP----------IVY------------------------------------------------------------------------------------------------------TSQN-------VA---LQL-------------------------------------------------------------------------------------------------------TLEDAQRNSP---------------------------------------------------------------------------------------------------------------Q-----------------LKVAQAQPVDPTC----R-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-V-----GQFD-----SP----------------EFHRQS---------------------------WEFYQ----------TLCQGEWKASFEELHD-----------------V----------------------------------DHFEIVENLTQKDNVLTQIILKT----------------------------------------------1159
1160 ----------------------------------------------DVPYGDGEGEKLDIYFPD----EDSKAFPLFLF----L-------H---------------------------------------------------------G--------------------G-----------------------------------------------------------YWQS--GSKDDSAFMVNPLTAQGIV-----V----------------------------------------VI------V-A---YD-IA----PK--------GTLDQ------------------------------MVDQ--VTRS----------------------------------------------V-----------------------------V--FL-------------------------------------------------QR--RYP-SNE--------------------------------------------------------G----I-YL--C-G--HS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LAAMVLL-----A--------------RW-------------TK-H-----GVTPN-LQGFLLVSGIYD-----------------LEP----------LIA------------------------------------------------------------------------------------------------------TSQN-------DP---LRM-------------------------------------------------------------------------------------------------------TLEDAQRNSP---------------------------------------------------------------------------------------------------------------Q-------------R--HLDVVPAQPVAPAC----P-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VL-V-----GQHD-----SP----------------EFHRQS---------------------------KEFYE----------TLLRVGWKASFQQLRG-----------------V----------------------------------DHFDIIENLTREDDVLTQIILKT----------------------------------------------1160
1161 -------------------------------------------------HSDRGAEVMPVCLPV----LCCAAFPVFVY----I-------H---------------------------------------------------------G--------------------G-----------------------------------------------------------YWQC--LSKDASGFAAPALLSQGVA-----V----------------------------------------VA------L-G---YD-IA----PR--------GHMDA------------------------------MVLQ--VRRS----------------------------------------------L-----------------------------A--FL-------------------------------------------------VK--QYH-RIR--------------------------------------------------------G----I-YL--C-G--HS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LAAMVLS-----T--------------DW-------------TE-F-----GVVPD-IRGAVLVSGVYD-----------------LEP----------LLH------------------------------------------------------------------------------------------------------TYVN-------DA---LNM-------------------------------------------------------------------------------------------------------SLEVAQRNSP---------------------------------------------------------------------------------------------------------------I-----------------LCVTQAVPVAASC----E-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VA-V-----AQHD-----SP----------------EFRRQS---------------------------QEYSQ----------ALRSAGWSVSLLDLAS-----------------V----------------------------------DHFDIIEKLSEETYVLTQV--------------------------------------------------1161
1162 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G----I-YL--C-G--HS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LAAMVLS-----T--------------DW-------------TE-F-----GVVPD-IRGAVLVSGVYD-----------------LEP----------LLH------------------------------------------------------------------------------------------------------TYVN-------DA---LNM-------------------------------------------------------------------------------------------------------SLEVAQRNSP---------------------------------------------------------------------------------------------------------------I-----------------LCVTQAVPVAASC----E-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VA-V-----AQHD-----SP----------------EFRRQS---------------------------QEYSQ----------ALRSAGWSVSLLDLAS-----------------V----------------------------------DHFDIIEKLSEETYVLTQV--------------------------------------------------1162
1163 -------------------------------------------------HSDRGAEVMPVCLPV----LCCAAFPVFVY----I-------H---------------------------------------------------------G--------------------G-----------------------------------------------------------YWQC--LSKDASGFAAPALLSQGVA-----V----------------------------------------VA------L-G---YD-IA----PR--------GHMDA------------------------------MVLQ--VRRS----------------------------------------------L-----------------------------A--FL-------------------------------------------------VK--QYH-RIR--------------------------------------------------------G----I-YL--C-G--HS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LAAMVLS-----T--------------DW-------------TE-F-----GVVPD-IRGAVLVSGVYD-----------------LEP----------LLH------------------------------------------------------------------------------------------------------TYVN-------DA---LNM-------------------------------------------------------------------------------------------------------SLEVAQRNSP---------------------------------------------------------------------------------------------------------------I-----------------LCVTQAVPVAASC----E-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VA-V-----AQHD-----SP----------------EFRRQS---------------------------QEYSQ----------ALRSAGWSVSLLDLAS-----------------V----------------------------------DHFDIIEKLSEETYVLTQVIL------------------------------------------------1163
1164 -----------------------------------------------VPYGDGEGEKLDIYFPA----DSSETFPVFVY----I-------H---------------------------------------------------------G--------------------G-----------------------------------------------------------YWQC--LSKDASGFAAPALLSQGVA-----V----------------------------------------VA------L-G---YD-IA----PR--------GHMDA------------------------------MVLQ--VRRS----------------------------------------------L-----------------------------A--FL-------------------------------------------------VK--QYH-RIR--------------------------------------------------------G----I-YL--C-G--HS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LAAMVLS-----T--------------DW-------------TE-F-----GVVPD-IRGAVLVSGVYD-----------------LEP----------LLH------------------------------------------------------------------------------------------------------TYVN-------DA---LNM-------------------------------------------------------------------------------------------------------SLEVAQRNSP---------------------------------------------------------------------------------------------------------------I-----------------LCVTQAVPVAASC----E-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VA-V-----AQHD-----SP----------------EFRRQS---------------------------QEYSQ----------ALRSAGWSVSLLDLAS-----------------V----------------------------------DHFDIIEKLSEETYVLTQV--------------------------------------------------1164
1165 -----------------------------------------------VPYGDGEGEKLDIYFPA----DSSETFPVFVY----I-------H---------------------------------------------------------G--------------------G-----------------------------------------------------------YWQC--LR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G----I-YL--C-G--HS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LAAMVLS-----T--------------DW-------------TE-F-----GVVPD-IRGAVLVSGVYD-----------------LEP----------LLH------------------------------------------------------------------------------------------------------TYVN-------DA---LNM-------------------------------------------------------------------------------------------------------SLEVAQRNSP---------------------------------------------------------------------------------------------------------------I-----------------LCVTQAVPVAASC----E-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VA-V-----AQHD-----SP----------------EFRRQS---------------------------QEYSQ----------ALRSAGWSVSLLDLAS-----------------V----------------------------------DHFDIIEKLSEETYVLTQV--------------------------------------------------1165
1166 -----------------------------------------------VPYGDGEGEKLDIYFPA----DSSETFPVFVY----I-------H---------------------------------------------------------G--------------------G-----------------------------------------------------------YWQC--LRMRQVSQPLRCCLRV------------------------------------------------------------------LL----LW--------PWVTT------------------------------LLPE--VRRS----------------------------------------------L-----------------------------A--FL-------------------------------------------------VK--QYH-RIR--------------------------------------------------------G----I-YL--C-G--HS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LAAMVLS-----T--------------DW-------------TE-F-----GVVPD-IRGAVLVSGVYD-----------------LEP----------LLH------------------------------------------------------------------------------------------------------TYVN-------DA---LNM-------------------------------------------------------------------------------------------------------SLEVAQRNSP---------------------------------------------------------------------------------------------------------------I-----------------LCVTQAVPVAASC----E-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VA-V-----AQHD-----SP----------------EFRRQS---------------------------QEYSQ----------ALRSAGWSVSLLDLAS-----------------V----------------------------------DHFDIIEKLSEETYVLTQVIL------------------------------------------------1166
1167 ----------------------------------------------NISYGMADDQKLDIFGAN----TLPRESPIFVF----I-------H---------------------------------------------------------G--------------------G-----------------------------------------------------------YWQV--MTKEDYSYIALPLTKAGAV-----T----------------------------------------IL------M-E---YT-RA----PK--------ANMGT------------------------------IVSE--VKQG----------------------------------------------M-----------------------------S--YI-------------------------------------------------MNFAKRR-ESC--------------------------------------------------------G----V-YL--C-G--HS-----------------AG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-LAAILLS-----V--------------DW-------------MAEC-----MIPSSLIKGALLISGIYD-----------------LRP----------LVP------------------------------------------------------------------------------------------------------SPIN-------DP---LKM-------------------------------------------------------------------------------------------------------TEATALENSP---------------------------------------------------------------------------------------------------------------I-------------T--VMEDIIKQSKSR------R-------------------------IE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-V-----ADED-----PA----------------ELRRQT---------------------------DEAWQ----------VLKHAGISSNSTLIPG-----------------V----------------------------------DHFGVVENIIQESFQVTQIAIE-----------------------------------------------1167
1168 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PALHTLVAYPVAKAGKI-----C----------------------------------------VI------V-G---KD-LA----PK--------VKITA------------------------------LVDE--CRKA----------------------------------------------I-----------------------------S--YF-------------------------------------------------AQ--IFP-LAS--------------------------------------------------------K----I-TL--V-G--HS-----------------SG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-ECAMLLA-----T--------------DW-------------SS-YNPDTASYLKRTLRKVVLVCGVFQ-----------------LEH----------LLE------------------------------------------------------------------------------------------------------TEDN-------KV---LQM-------------------------------------------------------------------------------------------------------TTEEARENSP---------------------------------------------------------------------------------------------------------------I-------------LPQNLKVLAQNVNKWGC----E-------------------------MV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MV-I-----AQHD-----AP----------------TILHWN---------------------------DAFME----------ELKSSGVKVTHKFLNG-----------------V----------------------------------DHFSVIGDITEESSALAQIISQ-----------------------------------------------1168
1169 ---------------------------------------KQGITVDHLRYGEGR-QLVDVFYSE----KTTNQAPLFVF----V-------H---------------------------------------------------------G--------------------G-----------------------------------------------------------YWQE--MDMSMSCSIVGPLVRRGYR-----V----------------------------------------AV------M-D---YN-LC----PQ--------VTLEQ------------------------------LMTQ--FTHF----------------------------------------------L-----------------------------N--WI-------------------------------------------------FDYTEMT-KVS--------------------------------------------------------S----L-TF--A-G--HS-----------------AG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-LLAQILM--------------------------------------RPNVITAQRSKMVWALIFLCGVYD-----------------LRE----------LSN------------------------------------------------------------------------------------------------------LESV-------NPKNILGL-------------------------------------------------------------------------------------------------------NERNIESVSP---------------------------------------------------------------------------------------------------------------M-------------LWEYTDVTVWNST--------K-------------------------IY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-A-----AEHD-----ST----------------TFIEQS---------------------------RHYAD----------VLRKKGYKASFTLFKG-----------------Y----------------------------------DHFDIIEETAIDDSDVSRFLRNI----------------------------------------------1169
1170 --------------------------WDYMWPYSIYRDLCLSPDGTQIPITICHRRDAFVQEATDFEAQPNTPKHCLIYVYGSY-----------------------------------------------------------------GEVPSMHFQLAPYMWMLRRRWT------------------------------------------------------------------------------------------------------------------------------------------V-AFAHVRGGG---------------------------------ELPNWGEQGKGKNKINAVHD--FIACCEHMI-----------------------------------------------------------------------KMGYTKPE----------------------------------------------------------------------------------------------------------------------L-MV--AAG--NS-----------------AGCVPIAAAMNMRGCGLFGNALLRSPFLDIIN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IDPDLPLSLAERDDWGDPLHSAEDYARLTQYDPYLNINDRVTYPGMMISTCLDDDRVPPWNTLKYVAKLRQQRRRKGTDPVARPLVLRLRSSG--------------------------------------------------GHYCWGDTENICEELSF----------------------------------------------------1170
1171 -------------------------------------------------------------KYALWWSPNAKNVAYLQFNDTEIPVIEYSYY---------------------------------------------------------G-----------------------------------------------------------------------------------------------------------------------------------------------------------------DSQYPRKITFPYPKAGAKNPTVRVFVIDTTNPEHFGPKEIFAPATIASSDHYVTWITWATDN--RICV----------------------------------------------------------------------------Q--WLKRVQNFS------------------------------------------------------------------------------------------------------------------VSAICDYNDRSRSWTCPENQQHIEESHTGWAG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FFVSAPYFTSDATSYYK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IY-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SDGDGYKHIHYVKDSVDKATQITSGKWEAIYIYKV-----------------------------------------------------------------------TDNEIFYSSNEFEGYPGRRNIYKIDLRRNPVTKQCITCHLRKERCQYYGARFSYNANYYALLCYGP----------------------------------------1171
1172 -------------------------------------------------------------------------LPGIIW----F-------Y---------------------------------------------------------P--------------------R-----------------------------------------------------------EYSNLQD-----------YERSRYT-----T----------------------------------------NI------N-A---FR-AV----PS--------ARPAS------------------------------A-------------------------------------------------------------------------------------Q--WMFVS-QGYAFIQPDIPIYGDAGRM-NDNYTRDLK----ENLDAVINA---AVDSGFV-DRD--------------------------------------------------------R----M-GL--G-G--HS-----------------YG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-STVNAMS-----L--------------MP-------------NF-KA-GIA------------GDGMYNRT---------------LTP----------FGF------------------------------------------------------------------------------------------------------QSER-------RN---FYQ-------------------------------------------------------------------------------------------------------AQSTYLDMSP---------------------------------------------------------------------------------------------------------------F-------------LRADK-------ISG------A-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LY-H-----ALEDQ--NTGT----------------DPISST---------------------------R-MYA----------ALQGLGKNAALYMYPY-----------------E----------------------------------DHSVSTYASDLDMWARWVAWMDIYV--------------------------------------------1172
1173 -----------------------------------------VKKKVVARRADGFSFNVNVTLPADY--KDGTRLPAMFW----F-------Y---------------------------------------------------------P--------------------R-----------------------------------------------------------EYDNQAA-----------YDRT-LS-----Q----------------------------------------GA------A-A---DR-RF----PS--------FGPRS------------------------------L-------------------------------------------------------------------------------------Q--FL-VT-QGYAVVEPDAPIFASDGQLPNDNYVADLR----NNLAAIIDA---LDTLQII-DRH--------------------------------------------------------R----L-GL--G-G--HS-----------------YG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-STVNAMV-----H--------------TP-------------FF-KA-GIA------------GDGAYNRT---------------LTP----------NGF------------------------------------------------------------------------------------------------------QSER-------RD---LWQ-------------------------------------------------------------------------------------------------------GRQTYLEMSP---------------------------------------------------------------------------------------------------------------M-------------LYADQ-------LNG------A-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MY-H-----STEDQ--NVGT----------------DPINST---------------------------R-LYH----------ALMGLGKTTSLYMYPY-----------------E----------------------------------DHGPIAKETVLDQWARWVAWLDKYV--------------------------------------------1173
1174 ----------------------------------------LQKEMIRYERKDGVQLTATLYLPPNYDPAKDGPLP-----------------------------------------------------------------------------------------------------------------------------------------------------------CLIWSYP----GE----FKSKDAA-----------------------------------------------------------------G----QV--------RGSPN------------------------------EFAG--IGPT----------------------------------------------S----------AL-----------------L--WL-AR-RFAILAGPTIPIIGEGNEEANDRYVEQLV----GSAEAAVQE---VIKRGVA-HPS--------------------------------------------------------K----I-AV--G-G--HS-----------------YG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MTANLLA-----H--------------AP-------------HL-FCCGIA------------RSGAYNRT---------------LTP----------FGF------------------------------------------------------------------------------------------------------QNED-------RT---LWE-------------------------------------------------------------------------------------------------------ATSTYVEMSP---------------------------------------------------------------------------------------------------------------F-------------ISANK-------IKK------P-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GEEDN--NPGT----------------LPMQSD---------------------------R-FFN----------ALKGHGALCRLVVLPF-----------------E----------------------------------SHGYSSRESIMHVLWETDRWLEKYC--------------------------------------------1174
1175 ----------------------------------------LQKEMIRYQRKDGVQLTATLYLPPGYDPSKDGPLP-----------------------------------------------------------------------------------------------------------------------------------------------------------CLFWSYP----GE----FKSKDAA-----------------------------------------------------------------G----QV--------RGSPN------------------------------EFAG--IGST----------------------------------------------S----------AL-----------------L--WL-AR-RFAILSGPTIPIIGEGDEEANDRYVEQLV----ASAEAAVEE---VVRRGVA-DRS--------------------------------------------------------K----I-AV--G-G--HS-----------------YG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MTANLLA-----H--------------AP-------------HL-FACGIA------------RSGAYNRT---------------LTP----------FGF------------------------------------------------------------------------------------------------------QNED-------RT---LWE-------------------------------------------------------------------------------------------------------ATNVYVEMSP---------------------------------------------------------------------------------------------------------------F-------------MSANK-------IKK------P-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GEEDN--NPGT----------------LTMQSD---------------------------R-FFN----------ALKGHGALCRLVVLPH-----------------E----------------------------------SHGYSARESIMHVLWETDRWLQKYC--------------------------------------------1175
1176 ----------------------------------------LYKEMIRYQRKDGVQLTAKLYLPPGYDASKDGPLP-----------------------------------------------------------------------------------------------------------------------------------------------------------CLVWSYP----GE----FKSKDAA-----------------------------------------------------------------G----QV--------RGSPN------------------------------EFSG--IGAT----------------------------------------------S----------PL-----------------L--WL-AR-GFAILSGPTIPIIGEGDVEANDSYVEQLV----TSAEAAVEE---VVRRGVV-HPD--------------------------------------------------------K----I-AV--G-G--HS-----------------YG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-MTANLLA-----H--------------AP-------------HL-FCCGIA------------RSGAYNRT---------------LTP----------FGF------------------------------------------------------------------------------------------------------QNED-------RT---LWE-------------------------------------------------------------------------------------------------------ATNTYVEMSP---------------------------------------------------------------------------------------------------------------F-------------MSANK-------IKK------P-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-H-----GEQDN--NSGT----------------LTMQSD---------------------------R-FFN----------ALKGHGVQSRLVILPF-----------------E----------------------------------SHGYSARESIMHVLWESDRWLQKYC--------------------------------------------1176
1177 -MALKQISSNKCFGGLQKVFEHDSVELNCKMKFAVYL----------------------PP--KAET--G--KCPALYW----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTEQNFISKS-GYHQA--ASEHGLVVIAPDTSPRG---CNIKGED------E-S---WD-FG-------------------------------------------T---GAGFYV--DATE----------------------------------------------D-----------------------------P--WKTNYRMYSYVTEELPQLINAN---F------P-VD--------------------------------------------------------------------------------PQR----M-SI--F-G--HS-----------------MG-----------------------------GHGALIC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LKNPG-----------------------K-------------Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KAYDA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LIDQ-----GKEDQ--FLSDGQLLPDNFITAC--TEKK-IP-VVFRLQE----------------------------------------------------------------------------------------------------G-YDHS-------------YYFIATFIADHIRHHAKYL----------------------------------1177
1178 -MALKQISSNKCFGGLQKVFEHDSVELNCKMKFAVYL----------------------PP--KAET--G--KCPALYW----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTEQNFISKS-GYHQA--ASEHGLVVIAPDTSPRG---CNIKGED------E-S---WD-FG-------------------------------------------T---GAGFYV--DATE----------------------------------------------D-----------------------------P--WKTNYRMYSYVTEELPQLINAN---F------P-VD--------------------------------------------------------------------------------PQR----M-SI--F-G--HS-----------------MG-----------------------------GHGALIC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LKNPG-----------------------K-------------YKSVSAFAPIC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPVLC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGKKAFSG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-TDQNKWKAYDATHLVKSYPGS---QLD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIDQ-----GKEDQ--FLSDGQLLPDNFITAC--TEKK-IP-VVFRLQE----------------------------------------------------------------------------------------------------G-YDHS-------------YYFIATFIADHIRHHAKYLN---------------------------------1178
1179 -MALKQISSNKCFGGLQKVFEHDSVELNCKMKFAVYL----------------------PP--KAET--G--KCPALYW----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTEQNFISKS-GYHQS--ASEHGLVVIAPDTSPRG---CNIKGED------E-S---WD-FG-------------------------------------------T---GAGFYV--DATE----------------------------------------------D-----------------------------P--WKTNYRMYSYVTEELPQLINAN---F------P-VD--------------------------------------------------------------------------------PQR----M-SI--F-G--HS-----------------MG-----------------------------GHGALIC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LKNPG-----------------------K-------------YKSVSAFAPIC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPVLC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGKKAFSG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-TDQSKWKAYDATHLVKSYPGS---QLD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIDQ-----GKDDQ--FLLDGQLLPDNFIAAC--TEKK-IP-VVFRLQE----------------------------------------------------------------------------------------------------G-YDHS-------------YYFIATFITDHIRHHAKYLN---------------------------------1179
1180 -MALKQISSNKCFGGLQKVFEHDSVELNCKMKFAIYL----------------------PP--KAET--G--KCPALYW----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTEQNFISKS-GYHQA--ASEHGLVVIAPDTSPRG---CNIKGED------E-S---WD-FG-------------------------------------------T---GAGFYV--DATE----------------------------------------------D-----------------------------P--WKTNYRMYSYVTEELPKLINAN---F------P-VD--------------------------------------------------------------------------------PQR----M-SI--F-G--HS-----------------MG-----------------------------GHGALIC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LKNPG-----------------------K-------------YKSVSAFAPIC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPVLC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGTKAFSG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-TDQNKWKAYDATHLVKSYPGS---QLD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIDQ-----GKDDQ--FLSDGQLLPDNFIAAC--TEKK-VP-VVFRLQE----------------------------------------------------------------------------------------------------G-YDHS-------------YYFIATFITDHIRHHAKYLN---------------------------------1180
1181 -MALKQISSNKCFGGLQKVFEHDSVELNCKMKFAIYL----------------------PP--KAET--E--KCPALYW----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTEQNFISKS-GFHQA--ASEHGLVVIAPDTSPRG---CNIKGED------D-S---WD-FG-------------------------------------------T---GAGFYV--DATE----------------------------------------------D-----------------------------P--WKTNYRMYSYVTEELPQLVNAN---F------P-VD--------------------------------------------------------------------------------PQR----M-SI--F-G--HS-----------------MG-----------------------------GHGALIC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LKNPG-----------------------K-------------YKSVSAFAPIC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPVLC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AWGKKAFGG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-TDQSKWKAYDATHLVKSYPGS---QLD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIDQ-----GKDDQ--FLSDGQLLPDNFIAAC--TEKK-VP-VVFRLQE----------------------------------------------------------------------------------------------------G-YDHS-------------YYFIATFITDHIRHHAKYLN---------------------------------1181
1182 -MALKQISSNRCFGGLQKVFEHSSVELKCKMRFAVYL----------------------PP--QAES--G--KCPALYW----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTEQNFISKS-GYQQA--ASEHGLVVIAPDTSPRG---CNIKGED------D-S---WD-FG-------------------------------------------T---GAGFYV--NATE----------------------------------------------D-----------------------------P--WKANYRMYSYVTEELPQLINAN---F------P-VD--------------------------------------------------------------------------------PQR----M-SI--F-G--HS-----------------MG-----------------------------GHGALIC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LKNPG-----------------------K-------------YRSVSAFAPIC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPVLC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SWGKKAFSG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-PDESKWKAYDATCLVKAYSGS---QID------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIDQ-----GKDDE--FLSNGQLLPDNFIAAC--TEKK-IP-VVFRLQE----------------------------------------------------------------------------------------------------L-LLHC-------------NF---------------------------------------------------1182
1183 -MALKQVSSNKCFEGFQKVFEHDSTELKCKMRFGIYL----------------------PP--KAET--A--KCPVLYW----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTEQNFITKA-GFQQA--AAEHGLIVVAPDTSPRG---CNIEGED------E-S---WD-FG-------------------------------------------T---GAGFYV--DATE----------------------------------------------D-----------------------------P--WKTNYRMYSYVRDELPKLINAN---F------P-TN--------------------------------------------------------------------------------PER----M-SV--F-G--HS-----------------MG-----------------------------GHGALIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LKNPG-----------------------K-------------YKSVSAFSPIC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPIQC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QWGKKALGG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-SDVSKWEAYDATQLVKSYPDS---HLD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIDQ-----GKDDQ--FLSAGQLLPDNFIAAC--TERK-IP-VVFRLQQ----------------------------------------------------------------------------------------------------G-YDHS-------------YFFIATFINDHIKHHAKFLN---------------------------------1183
1184 -MALKEISNNKCFDGFQKVYEHDSTELKCKMKFGIYL----------------------PP--KAVT--E--KCPVLYW----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTEQNFITKA-AFHQA--AAEHGLIVVAPDTSPRG---CNIKGED------D-S---WD-FG-------------------------------------------T---GAGFYV--NATE----------------------------------------------E-----------------------------P--WKTNYRMYSYIKDELPKLINAN---F------P-AD--------------------------------------------------------------------------------SGR----M-SI--S-G--HS-----------------MG-----------------------------GHGALIL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LKNPG-----------------------K-------------YKSVSAFAPIC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPVQC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGKKAFSG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-SSVKDWEAYDATHIVKSYEGP---PLD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIDQ-----GKDDQ--FLSAGQLLPDNFIAAC--TERK-VP-VVFRMQQ----------------------------------------------------------------------------------------------------G-YDHS-------------YYFITTFINDHIRHHAKYLN---------------------------------1184
1185 ---ITQVSSNKCFGGYQKVYSHESEELKCKMNFSVYL----------------------PP--KAED--AGVKLPVIYW----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCNEQNFTQKA-GGQKL--AASHGCIIVCPDTSPRG---CNIEGEE------E-G---WD-FG-------------------------------------------T---GAGFYV--DATE----------------------------------------------E-----------------------------K--WKMNYRMFSYVTKELPLLISSN---F------P-AD--------------------------------------------------------------------------------PSL----M-SI--M-G--HS-----------------MG-----------------------------GHGALIC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LKNPG-----------------------L-------------YKSVSAFAPIC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPVNC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGEKAFSG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-SDKNLWKEWDASCLAATYQGP---PLQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IFVDQ-----GEEDQ--FLKDGQLLPDNLVESC--AKAG-VP-IILRKQA----------------------------------------------------------------------------------------------------G-YDHS-------------YYFIATYLEDHFTHHAKFL----------------------------------1185
1186 -MAVSEVSCNKMFGGFQKVFSHESTQLKCKMNFGVYL----------------------PP--QAES--G--KCPVLYW----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTEQNFVTKA-CAQRA--AAEHGIIIIAPDTSPRG---CNIEGEE------D-G---WD-FG-------------------------------------------T---GAGFYV--NATE----------------------------------------------D-----------------------------K--WKTNYRMYSYVTEELPSVVNSS---F------P-VD--------------------------------------------------------------------------------SDR----Q-SI--F-G--HS-----------------MG-----------------------------GHGALIC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LKNPG-----------------------K-------------YRSVSAFAPIC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPINC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGQKAFSG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-SNKETWKEYDASELVKKYQGP---PVD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIDQ-----GKADN--FLPAGQLLPDNFVAAC--KESK-VP-VVLRMQE----------------------------------------------------------------------------------------------------G-YDHS-------------YYFMASFMDDHIKHHAKHLK---------------------------------1186
1187 -MALTEVSSNKMFGGYQKVFSHESKEVKCTMKFGIFL----------------------PP--QAEN--G--KCPILYW----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTEQNFVTKA-GAQRV--AAELGFVVVAPDTSPRG---CNIEGEE------D-G---WD-FG-------------------------------------------T---GAGFYV--NATQ----------------------------------------------E-----------------------------K--WKTNYRMYSYVTEELPALINAN---F------P-VL--------------------------------------------------------------------------------GDK----Q-GI--F-G--HS-----------------MG-----------------------------GHGALIC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LKNPG-----------------------K-------------YLSVSAFAPIC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPVNC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGKKAFSG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-DNQEDWKEYDACCLVKKYNGP---PLK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILVDQ-----GKADN--FLPAGQLLPDNFVTAC--AEAK-ME-LVMRMQE----------------------------------------------------------------------------------------------------G-YDHS-------------YYFMATFIEDHVRHHAKFL----------------------------------1187
1188 -----------------------SSTCNGEMHFAVYQ----------------------PP--QATH--K--PVPILYF----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------ICTEENFMVKAGGVQRF--AAEYGLMLVTPDTSPRH---TGIAGED------D-D---WD-FG-------------------------------------------T---GAGFYV--DATE----------------------------------------------E-----------------------------P--WRKNYQMYSYVVHELPSLINAN---F------P-TQ--------------------------------------------------------------------------------PEK----Q-GI--F-G--HS-----------------MG-----------------------------GHGALVC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-MRNPE-----------------------L-------------YKSVSAFAPIT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------APMRC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGQKAFGG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-RNQESWRAYDASELVKQVGY----HSS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIDQ-----GTADK--FLAE-QLLPEVFEKAC--ADVK-QP-LNLRYQE----------------------------------------------------------------------------------------------------G-YDHS-------------YYFIASFIEDH------------------------------------------1188
1189 -MSVKEVASNRSFGGWQKVYEHESEECKCTMRFGVYF----------------------PP--QAES--K--KCPALYY----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTEQNVVTKG-GTQGP--AAKQGLVIITPDTSPRG---CNIEGED------D-G---YD-FG-------------------------------------------S---GAGFYV--NATE----------------------------------------------E-----------------------------K--WKTNYRMYAYVTKELPQVISAN---F----GDK-VD--------------------------------------------------------------------------------GDK----M-SI--F-G--HS-----------------MG-----------------------------GHGALVC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LKEPG-----------------------K-------------YKSVSAFAPIV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPMQC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGQKALGG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-SDKEAHKEYDACELGKKYKGP---ALD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIDQ-----GTSDQ--FLQR-ELLPDHFKIVC--ADAG-IK-LNLRFQE----------------------------------------------------------------------------------------------------G-YDHS-------------YFLMSTFMEDHINHHAKYLN---------------------------------1189
1190 ------LSQSKTFDGIVFKYSHDSTLLACKMKFSVFL-----------------------P--KSVS--K--AIPALYF----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCNEDNFITKA-GAIKK--ASQLGLALICPDTSPRG---LGIDGED------D-S---WD-FG-------------------------------------------S---GAGFYV--NATE----------------------------------------------S-----------------------------K--W-SRYQMYSYIMHELPELVNAH---L------P-ID--------------------------------------------------------------------------------PSR----V-SI--F-G--HS-----------------MG-----------------------------GHGALVC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LGNPG-----------------------H-------------FKSVSAFAPIS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPIHC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KWGVKAFGG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTENKESWKQYDATELASKYTG---PKLA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLIDQ-----GSEDS--FLQDGQLLPDRFVASANTNESHL-L-VEYRLQE----------------------------------------------------------------------------------------------------G-YDHS-------------YWFISTFVDDHLEFHWKHL----------------------------------1190
1191 -----EVSKAKSFGGWQKVFQHHSDVLKCDMKFAIYL----------------------PQ--ESET--K--KVPVIYY----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTEQNVIAKS-GFQRY--ASEAGVAIVAPDTSPRG---CNIEGED------D-S---YD-FG-------------------------------------------S---GAGFYI--NATT----------------------------------------------E-----------------------------K--WKENYNMYSYVTKELPAAIETN---F------N-IE--------------------------------------------------------------------------------PSR----K-SI--F-G--HS-----------------MG-----------------------------GHGALIC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LKNPG-----------------------S-------------YISVSAFAPIC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPSNC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGKKAFTG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-PDEETWKEWDATELVKSYKGP--NLGY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIDQ-----GADDN--FLKEKQLLPEAFVDAC--RVSN-VP-VVLQMQE----------------------------------------------------------------------------------------------------G-YDHS-------------YYFVSTFIGGQIQHHAKLL----------------------------------1191
1192 -----EVSKAKSFGGWQKVFQHHSDVLKCDMKFAIYL----------------------PQ--ESET--K--KVPVIYY----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTEQNVIAKS-GFQRY--ASEAGVAIVAPDTSPRG---CNIEGED------D-S---YD-FG-------------------------------------------S---GAGFYI--NATT----------------------------------------------E-----------------------------K--WKENYNMYSYVTKELPAAIETN---F------N-IE--------------------------------------------------------------------------------PSR----K-SI--F-G--HS-----------------MG-----------------------------GHGALIC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LKNPG-----------------------S-------------YISVSAFAPIC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPSNC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGKKAFTG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-PDEETWKEWDATELVKSYKGP--NLGY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIDQ-----GADDN--FLKEKQLLPEAFVDAC--RVSN-VP-VVLQMQE----------------------------------------------------------------------------------------------------G-YDHS-------------YYFVSTFIGGQIQHHAKLL----------------------------------1192
1193 --SLTQTACNKIFGGWQKIFTHDSSETKCKMTFGIYL----------------------PP--QADD--E-CKVPVIYW----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTEQNFVTKA-GAQRY--AAQHGIAIVAPDTSPRG---CNIEGED------E-S---YD-FG-------------------------------------------S---GAGFYV--DATQ----------------------------------------------E-----------------------------K--WKTNYRMYSYITKELPDIVNAN---F------P-VL--------------------------------------------------------------------------------ADK----Q-SI--M-G--HS-----------------MG-----------------------------GHGALTL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LKNPG-----------------------M-------------YQSVSAFAPIC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPVQC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AWGQKALAG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-EDKEAWMDSDSCCLVKNYSGP---TSD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIDQ-----GQDDN--FLSQGQLLPDNFLAAC--NSNN-VP-VILRMQE----------------------------------------------------------------------------------------------------G-YDHS-------------YFFIATFIGEHIAHHAKYL----------------------------------1193
1194 ------VSSARCFQSSINVYSHDSEELQCKMKFGVIL----------------------PD--QAKE--S--KLPVLYW----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTEQNFLTKS-AAHKA--ACDNGVIIVCPDTSPRG---CNVEGEE------D-S---WD-FG-------------------------------------------T---GAGFYL--DATE----------------------------------------------E-----------------------------K--WKKHYRMYSYIVKEFPKIISAN---F------P-VI--------------------------------------------------------------------------------PGK----Q-SI--F-G--HS-----------------MG-----------------------------GHGAITI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LKNPG-----------------------M-------------FKSLSAFSPIS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPING---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGKKAFTG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-PNQESWRCYDATELAKNYDGD---EIE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLVDQ-----GAADP--YLKDELLLP-NFCNAC--NNNKKVK-LTYREHV----------------------------------------------------------------------------------------------------G-YDHG-------------FYFIATFIEDHIKYHARYL----------------------------------1194
1195 ------------------------------MTFAVYL----------------------PP--LAES--S--KCPVLYW----I-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTEQNFITKS-GFQKF--ASELGIIVVCPDTSPRG---ANIEGEN------N-S---WD-FG-------------------------------------------L---GASYYV--DATE----------------------------------------------E-----------------------------K--WKKNYRMYSYITKELPDIISNN---F------P-VL--------------------------------------------------------------------------------KDV----Q-SI--I-G--HS-----------------VG-----------------------------GHGALIC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LKNPV-----------------------K-------------YKSVSVFAPVS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPINC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGKKAFTA-----------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-LDQETWKEYDACELGKKYEGP---LLN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIDQ-----GSSDS--FAKD-QLLTENFIKVC--NENSLLK-VNYRLRE----------------------------------------------------------------------------------------------------G-YDHG-------------YYFISTFIEEHIRYHAAAL----------------------------------1195
1196 ---LTEVSCNKSFGGLQKVFSHDSSECKCKMTFSVYL----------------------PS--QSES--G--PCPTLIY----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTDQNVTNKG-GFQRV--AAQYGMVVVCPDTSPRG---CSIEGED------E-S---YD-FG-------------------------------------------S---GAGFYL--DATE----------------------------------------------E-----------------------------K--WKTNYRMSSYVTKELFDLIVNS---F------P-VN--------------------------------------------------------------------------------PDK----V-AI--T-G--HS-----------------MG-----------------------------GHGALTL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-LKNPH-----------------------L-------------FKSISAFAPIC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPISC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGQKAFKG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-PDENTWKEYDACELVSCYDGP---PRE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIDQ-----GKGDN--FYNQKQLLPENFVTSC--QVSR-TG-CIMNLRE----------------------------------------------------------------------------------------------------G-YDHS-------------YYFISTFMEDHIKFHSQHL----------------------------------1196
1197 -------------------YSHHSDTLNCDMEFSVYL----------------------PP--QSKN--K--KYPVLYW----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTAENFTTKS-GFQRY--AADHGVIVVAPDTSPRG---AQVKDIK------D-E---WD-IG-------------------------------------------C---GAGFYV--NATT----------------------------------------------N-----------------------------E--WDQHFKMYDYITKELPTLIKDN---F--------NC--------------------------------------------------------------------------------SDK----A-SI--S-G--HS-----------------MG-----------------------------GHGALIC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-LKNPG-----------------------M-------------YQSTSAFSPIV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPVNC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGQKAFST-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-EDIELWSAWDSVELIKQGHQ----VNH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LFVDQ-----GLADN--FLDN-QLKTDALKQAC--ESKK-IN-LELKYRQ----------------------------------------------------------------------------------------------------G-YDHS-------------YYYISSFIGEHI-----------------------------------------1197
1198 ---VSEVAVNKQFGGFNRRYKHKSSSLGCEMTFTIYY----------------------PP--AAAG--G--KVPVLYF----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCNDENFITKA-GAQRQ--AAARGVALIAPDTSPRG---LGVEGES------E-S---WD-FG-------------------------------------------V---GAGFYV--NATQ----------------------------------------------P-----------------------------K--W-KNWRMYEYVTEELPALLRAAPLGS------S-LD--------------------------------------------------------------------------------LDR----A-SV--F-G--HS-----------------MG-----------------------------GHGALVV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-LRNPT-----------------------R-------------FRTISAFSPIS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPINA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGVKAFTG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-EDKAAWKEYDASELLRGFNGD--VKPA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILVDT-----GSADK--FLTE-QLKPDSLEAAA--KESGYGN-VTVRMQD----------------------------------------------------------------------------------------------------G-YDHS-------------YFFISSFIDDHINFHADAL----------------------------------1198
1199 -----QLSKSKMFGGHILRFRHHSAALGCPMTFSLFV-----------------------P--ASPA--S--NLPVLYF----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCNDENFVIKS-GAQRA--AAAHGIALVAPDTSPRG---LNIEGEA------D-S---WD-FG-------------------------------------------V---GAGFYL--NATN----------------------------------------------E-----------------------------K--W-KNWRMYDYVVKELPKVL--SDNFE------Q-LN--------------------------------------------------------------------------------TSR----A-SI--F-G--HS-----------------MG-----------------------------GHGALTI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LKNTD-----------------------K-------------YKSVSAFAPIA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPINC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGQKAFTN-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-TTKSEWEDYDATCLIKKCNG---VSTP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIDQ-----GDDDK--FLAE-QLLPGNFEEAC--KAAGV-P-LTLRMQP----------------------------------------------------------------------------------------------------G-YDHS-------------FFFIATFIDDHIAHHAQFL----------------------------------1199
1200 -------SETACFGGRLLKCVHQSKATKTQMTFTVFL----------------------PP--AAAS--S--AVPVLYY----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTDDNFIQKA-GAQRI--AALRGVALVAPDTSPRG---AGVAGED------E-G---WD-FG-------------------------------------------T---GAGFYV--DATE----------------------------------------------A-----------------------------G--WKENYRMYAYVTEELPAAVAAS---F------PAVD--------------------------------------------------------------------------------TSK----A-SV--C-G--HS-----------------MG-----------------------------GHGALVV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-FRNPD-----------------------K-------------YRSVSAFSAIC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPVEC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGKKAFSG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-KDEAAWKEYDATELMRR-DGPFPSLGK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILLDQ-----GSADN--FLTAGQLIPEALVKAC--EDKG-QP-CEMRMQD----------------------------------------------------------------------------------------------------G-YDHS-------------YFFISSFIEDHVSMHADRL----------------------------------1200
1201 ------------------------------MRFAVYL----------------------PP--AAKD--R--PVPVVYY----L-------A---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTEETATIKA-GAQAH--AARLGLALVMPDTSPRG---ANIEGED------D-D---WD-FG-------------------------------------------S---GAGFYL--DATS----------------------------------------------E-----------------------------P--WSKNYRMYSYLTDELRKLVASR---F------P-VL--------------------------------------------------------------------------------DDA----T-GI--C-G--HS-----------------MG-----------------------------GHGALVI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LRNPD-----------------------S-------------YRSLSAFAPIC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------APMQC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGEKAFSS-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-DDPSARKKYDAVSLIAEGAHF---EGG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILVDQ-----GEDDP--FLES-QLHPHLLQDAC--DKAG-LA-LRLRRHA----------------------------------------------------------------------------------------------------G-YDHG-------------YYFIQSFIGEHLEHHARGLD---------------------------------1201
1202 -MAATLVSSNRSFKGRQFVYKHASSTTQCEMTFGVYI----------------------PD--HKPD--E--KLPALFY----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTHANFMEKS-GFQQF--ASKHRLVVVHPDTSPRG---VDVDGDS------E-S---WD-FG-------------------------------------------K---GAGFYV--NATV----------------------------------------------E-----------------------------K--WAKNYRMYDYIVKELLEEVVPS---V-----AP-ID--------------------------------------------------------------------------------LAK----I-GI--F-G--HS-----------------MG-----------------------------GHGALTI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-LRNSS-----------------------K-------------FQSISAFAPIC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPITV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGQKALTG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GDEDKSTWNQYDASEVLKAYSGP---KRE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILVDQ-----GAADN--FLA--QLKPETL------KSKENAE-IVVRMQA----------------------------------------------------------------------------------------------------E-FDHS-------------YYFIASFMADHFEHHAKILN---------------------------------1202
1203 ------IEKHASFGGSQEVYRHQSIALNCSMKFSIYL----------------------PP--HDKD--E--RLPVLYW----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCNEQNFITKA-GAQKY--AAEHKVIIVAPDTSPRG---EDVP-DH------A-D---YD-LG-------------------------------------------Q---GAGFYV--NATQ----------------------------------------------A-----------------------------P--WSQHFKMYDYIVEELRNLIDLN---F--------PT--------------------------------------------------------------------------------NQV----Q-SI--M-G--HS-----------------MG-----------------------------GHGALVI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-LKNPE-----------------------L-------------YKSISAFAPIV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------APSQV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGKKAFTH-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-ETETLWKSYDAIELI--KNAE--VHLP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILVDQ-----GTADD--FLEE-QLRPKLLSNIC--LEQE-YP-LTLNLRE----------------------------------------------------------------------------------------------------G-YDHS-------------YYFIASFIEKHIEFHSKFL----------------------------------1203
1204 ------IEKHVSFGGWQNMYRHYSQSLKCEMNVGVYL----------------------PP--KAAN--E--KLPVLYW----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCNEQNFITKS-GMQRY--AAEHNIIVVAPDTSPRG---SHVA-DA------D-R---YD-LG-------------------------------------------Q---GAGFYL--NATQ----------------------------------------------A-----------------------------P--WNEHYKMYDYIRNELPDLVMHH---F--------PA--------------------------------------------------------------------------------TAK----K-SI--S-G--HS-----------------MG-----------------------------GLGALVL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LRNPD-----------------------E-------------YVSVSAFSPIV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPSQV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGQQAFAA-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-ENKDAWLDYDPVSLI--SQGQ--RVAE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IMVDQ-----GLSDD--FYAE-QLRTPNLEKIC--QEMN-IK-TLIRYHE----------------------------------------------------------------------------------------------------G-YDHS-------------YYFVSSFIGEHIAYHANKL----------------------------------1204
1205 ---MEMLEEHRCFEGWQQRWRHDSATLNCAMTFSIFL----------------------PP--PRDN--A--PPPVLYW----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCNDENFTTKA-GAQRI--AAELGIVLVMPDTSPRG---EQVA-ND------D-G---YD-LG-------------------------------------------Q---GAGFYL--NATQ----------------------------------------------Q-----------------------------P--WATHFRMYDYLRDELPALIHSQ---F--------NV--------------------------------------------------------------------------------SDR----C-AI--S-G--HS-----------------MG-----------------------------GHGALIM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LKNPG-----------------------K-------------YTSVSAFAPIV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPCRV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGEKAFSA-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-EDKTQWTEWDSCALMLASKPT--DAIP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLIDQ-----GDSDQ--FLAD-QLQPAVLAEIA--RQTA-WP-MTLRIQP----------------------------------------------------------------------------------------------------G-YDHS-------------YYFIASF----------------------------------------------1205
1206 ------LEEHRCFEGWQQRWRHDSSTLNCPMTFSIFL----------------------PP--PRDH--T--PPPVLYW----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCNDENFTTKA-GAQRV--AAELGIVLVMPDTSPRG---EKVA-ND------D-G---YD-LG-------------------------------------------Q---GAGFYL--NATQ----------------------------------------------P-----------------------------P--WATHYRMYDYLRDELPALVQSQ---F--------NV--------------------------------------------------------------------------------SDR----C-AI--S-G--HS-----------------MG-----------------------------GHGALIM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LKNPG-----------------------K-------------YTSVSAFAPIV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPCSV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGIKAFSS-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-EDKNAWLEWDSCALMYASNAQ--DAIP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLIDQ-----GDNDQ--FLAD-QLQPAVLAEAA--RQKA-WP-MTLRIQP----------------------------------------------------------------------------------------------------G-YDHS-------------YYFIASFIEDHLRFHAQYL----------------------------------1206
1207 ---MELLEEHRCFDGQQQRWRHHSPVLNCAMTFSIFL----------------------PP--ERE---T--PPPVLYW----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCNDENFTTKA-GAQRI--AAELGIALVMPDTSPRG---DEAA-ND------D-G---YD-LG-------------------------------------------Q---GAGFYL--NATE----------------------------------------------A-----------------------------P--WAAHYRMYDYLRDELPALIRSE---F--------SV--------------------------------------------------------------------------------GER----C-AV--S-G--HS-----------------MG-----------------------------GHGALIM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LKNPG-----------------------R-------------YASVSAFAPIV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPSQV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGKKAFTA-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-ADESAWHSWDSCALMQASRPE--DAVP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLIDQ-----GDNDP--FLAG-QLQPAVLAEVA--RQKA-WP-LTLRIQP----------------------------------------------------------------------------------------------------G-YDHS-------------YYFIASFIEDHLRFHAQHL----------------------------------1207
1208 ---LEKLSSNKAAGSFLTKYKFPSASLALPTQFNVFV----------------------PSSASPDS-----PAPVLFY----L-------A---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTEDTGAQKG-GFFNT--AGKEGIALVFPDTSPRG---AGVEGED------D-D---WQ-LG-------------------------------------------T---GAGFYI--NAET----------------------------------------------D-----------------------------K--WRKHYNMYDLIVKELPEVLKEANLGL---------D--------------------------------------------------------------------------------FSK----W-SI--M-G--HS-----------------MG-----------------------------GHGALSI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LKNPG-----------------------L-------------FKSASAFAPIC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPAAV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGINAFSN-----------------------YL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSSSSWLAHDSSALLPQFAD----EPK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILVDV-----GTDDQ--FLKQGQLQPQTLEKAG-------KKGVEVRMQD----------------------------------------------------------------------------------------------------G-YDHS-------------YYFISTFGPEHVAFHAKYL----------------------------------1208
1209 -MSFKTNATIIQFGGILHKLSHDSALTKTPMDVNVFI----------------------PPINPTST--TKQKIPVLIY----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTPQNATEKS-FFQYW--ASKYGFAIVFPDTSPRG---AKIEGED------D-S---WD-FG-------------------------------------------T---GAGFYV--DATQ----------------------------------------------S-----------------------------P--WNKNYQMYSYIHKELLDKLSEQ---F------IELDF-------------------------------------------------------------------------------ENN----I-GI--T-G--HS-----------------MG-----------------------------GMGALVG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LTQPK-----------------------K-------------YKSISAFAPIS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPSIV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QWGEKNFGN-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GNDDKQNWYKYDPTHLIKQYTTTNDYQPS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIHQ-----GLNDN--FYAD-QLKPENFVKAA--KEANYKGEIDLRLVD----------------------------------------------------------------------------------------------------G-YDHS-------------YFFISSFVEDHAKHHAKYL----------------------------------1209
1210 ------------FGGKLLKLSHAAKSTNCEMAFNLYL----------------------PP-QAYKT--PSQKLPLLIY----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTGDNCSEKG-FFQHG--ASKKGIAVLYPDTSPRG---LNIPGEN------D-T---WD-FG-------------------------------------------T---GAGFYV--NATK----------------------------------------------E-----------------------------P--YNKGYNMYTYITEELPATVFEA---F------PQID--------------------------------------------------------------------------------SSR----V-SI--T-G--HS-----------------MG-----------------------------GHGALTL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-LRNPG-----------------------K-------------YKSVSAFAPIS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPINC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AWGQKAFGG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEENKEKWKEHDATELVKGWAGKN---VD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIDV-----GTGDN--FYKQGQLLPENLEKAA--KEAGVTG-INVRYQP----------------------------------------------------------------------------------------------------D-YDHS-------------YYTMATFSDDHVEHAAKYL----------------------------------1210
1211 ------------CGGRLIKLSHNSNSTKTSMNVNIYL----------------------PKHYYAQDFPRNKRIPTVFY----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTPDNASEKA-FWQFQ--ADKYGFAIVFPDTSPRG---DEVANDP------EGS---WD-FG-------------------------------------------Q---GAGFYL--NATQ----------------------------------------------E-----------------------------P--YAQHYQMYDYIHKELPQTLDSH---FNKN-GDVKLDF-------------------------------------------------------------------------------LDN----V-AI--T-G--HS-----------------MG-----------------------------GYGAICG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LKGYSGK---------------------R-------------YKSCSAFAPIV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPSNV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGQKAFKG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-EEKAQWEAYDPCLLIKNIRHV--GDDR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIHV-----GDSDP--FLEE-HLKPEVLLEAV--KATSWQDYVEIKKVH----------------------------------------------------------------------------------------------------G-FDHS-------------YYFVSTFVPEHAEFHARNL----------------------------------1211
1212 -------------GGRLLKLSHVSDACKSTMDVNVYL----------------------PVQYYKK---TERAIPTIYY----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTPQNASEKA-FWQAQ--ADKYGFAVVFPDTSPRG---VEIPKDP------EDS---WD-FG-------------------------------------------E---GAGFYV--NATM----------------------------------------------E-----------------------------P--FARYYNMYDYIHNELPGLLAKH---FSAGPQNAKVDF-------------------------------------------------------------------------------LEN----I-GI--T-G--HS-----------------MG-----------------------------GFGALSG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LKNYRNA-----K--------------WR-------------FKSCSAFAPIV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPSVV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGQKAFRG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-EDKALWEQYDPCCLVKKVENA--GHDT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIHV-----GTSDP--FLEK-HLKPELLAEAI--KGTSWEGKVSINLVD----------------------------------------------------------------------------------------------------G-FDHS-------------YYFVSTFVPEHAKYHAEKL----------------------------------1212
1213 -MTIQTVSTNKSYGGVQGVYRHASQATGTDMVFSVYV----------------------PP--HADG--A--KLPVVWY----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTHANVTEKG-EFRKA--CAELGLIFVAPDTSPRG---PDVPGDP------NNA---YD-FG-------------------------------------------L---GAGFYV--DATQ----------------------------------------------E-----------------------------P--FARNYRMWSYVTDELPKLVAEN---F------P-VD--------------------------------------------------------------------------------PRR----Q-SV--M-G--HS-----------------MG-----------------------------GHGALTV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LRNPH-----------------------R-------------YRAASAFAPIV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------APSQV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGIKALTG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-PNKDNWRSHDTVALIEDGAK----YSG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FLVDV-----GDADN--FLKE-QLKPELLQAAC--TKAS-IP-LTLRRQA----------------------------------------------------------------------------------------------------G-YDHS-------------YYFISTFMGDHLNWHAERL----------------------------------1213
1214 -------------GGLLHRVKHKSSSTNTDMIFAIFL----------------------PSVYKIGT--NKAPLPAIYW----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTDQNFCQKA-GGSAFARAEEEGIAMIMPDTSPRG---EDIPSDD--------S---YD-LG-------------------------------------------T---GGGFYV--DATN----------------------------------------------A-----------------------------P--WDANYNMESYISKELPALVESE----------WGVGA-------------------------------------------------------------------------------NGV----R-SI--C-G--HS-----------------MG-----------------------------GHGALTL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LKAPAG----------------------S-------------WASVSAFSPIC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------HPTAC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGEKAFKN-----------------------YF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G--SVDAGKPHDATLLLKN-SGTGSIFDD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIDE-----GTNDE--FRDAGQLLVEDFEKAA--EEVG-QK-LTVRRQD----------------------------------------------------------------------------------------------------G-HDHS-------------YHFIAAFIVDHIGFHASRL----------------------------------1214
1215 ----RLLESKKAFNAEVNQYEHNSPTLGCVMKFSVIN----------------------GG--SGSD--E--KLPVIYW----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCSDRNFIEKA-GAFRA--AVENRVIIVCPDTSPRG---VDIEGDS------E-S---WD-FG-------------------------------------------K---GAGFYL--NATQ----------------------------------------------P-----------------------------K--WAANYKMYDYVTNELMEIIEQT---V--------KT--------------------------------------------------------------------------------NGK----K-AI--M-G--HS-----------------MG-----------------------------GHGALTI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-LRNPG-----------------------V-------------YTSVSAFAPIC-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPMQC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGNKAFTG-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-DDQEQWKAYDATEQMKGMKAA--PFDD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIDV-----GDKDN--FLTAGQLLPENFKAAC--DQVG-QK-CSLRMQP----------------------------------------------------------------------------------------------------G-YDHS-------------YFFIATFIEDHIKFHKQRL----------------------------------1215
1216 ------IEQHRSFEGEQRKYSHYSEVLQCDMKFSIYL----------------------PS--NKEK--K--KIPLIWW----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTDDNFSQKS-GFQRL--AEKHQVAVIMPDTSPRGEYVSDVA-----------A---WD-LG-------------------------------------------Q---GAGFYL--NATQ----------------------------------------------D-----------------------------P--WAQHYKMYSYIVDELTSIASTI---V------P-NF--------------------------------------------------------------------------------SGE----E-SI--M-G--HS-----------------MG-----------------------------GHGALAI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-LKNAK-----------------------R-------------FKAISAFSPIL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPSQV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PWGINAFTS-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-EDKDSWKQWDASDLIKED-N----IPP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILIMQ-----GSQDE--FYPK-QLEEHIFLENA--QKNS-QM-VTYKKME----------------------------------------------------------------------------------------------------G-YDHS-------------YFFISTFLNEHFSFH--------------------------------------1216
1217 ------LSKSKSFNGEVRRYSHKSTSLSCDMKFHVYV----------------------PS--KSST-----PSSVLWF----L-------S---------------------------------------------------------G--------------------L--------------------------------------------------------------------------------------TCTDENFIQKS-GAIQY--ASQNNIFLVCPDTSPRG---ITIENAE------D-K---WQGPG-------------------------------------------F---GAGYYL--NSTT----------------------------------------------D-----------------------------K--YKAHFQMFTYITKELFELINKE---F------TDTIN-------------------------------------------------------------------------------INK----H-SI--F-G--HS-----------------MG-----------------------------GLGAISL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-IKTNG-----------------------Q-------------YKSVSAFSPIS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPVNC---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DWSLHSFKE-----------------------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GTENKEAWLQYDPCHLLKNYDGK---PFD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LLVDQ-----GSADE--FFND--LKFDNLELAC--KENSKIN-LIARLQD----------------------------------------------------------------------------------------------------G-YNHG-------------YFYISTFIKDHIEYHSKHLN---------------------------------1217
1218 ------------------------------------------------------------VCGSVYTPQSKGKHALIIC----P-----------------------------------------------------------------N--------------------G------------------------------------------------------------------------------------------------------------------------------------------------HF-GG----GRYREDQQQRMGTL-----ARMGAVCVDYD-------------LFGWGESILQVG-------------------------------------------------------------------------------STAHR---------SS----------------AAHTIQAMNGLLILDY---MLASRKDIDTK--------------------------------------------------------R----I-GA--N-G--GS-----------------GG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-HTVLLTT-----L--------------DD---------------RFTASAPVVS-------------LASHFDGGCPCESGMPIQLSAGGTCNAELAATFAP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------QL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-S-----DGGDW--TASVPA--------------LEFPYL----------------------------------------------------------QRIYGFYDAKDNVTNVHLPK-------------------------------EKH--DFGPNKRNAVYDFFAE-------------------------------------------------1218
1219 ---------------------------------------------------------------DIKAGAEK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YE-VG----GRY--PLQARCVEL-----ARMGCMVFHYD-------------MLGYADGFCLSY-------------------------------------------------------------------------------DLIHR-FAKQRPEMSSEKNWGLFSAQSELRLISALGLQTLNSIRALDW----VCSLSEVDQK--------------------------------------------------------R----I-GI--T-G--AS-----------------GG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-QTFILAA-----I--------------DQ---------------RITAAFPAVM-------------VSTAMQGGCTCENATYLRV---GTGNIEFAALLAP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------L--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GM-T-----AADDW--TKEIES--------------KGLPEL----------------------------------------------------------KQHFKMLGVPEKVSGKYYP--------------------------------FPH--NYNYVSRAMMYEFFNQH------------------------------------------------1219
1220 -----------------------------------------------GFAALALAFVDANGLP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFDYGNLGNN----------VEL-------------------QF---EYFEMAV----------------------------------------------------------------------------K--FM--------SNHKDVNSKN-------------------------------------------------------------------------------------------------------L-AV--F-G--SS-----------------MS-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PI--ALAIGTHLRGI--------------T-CV---VWV---------------NSTIILQSISLMYKGKKLLSTATYDMEKWEEE-----------KMYRLMLRRTQQTPDDIMNQTFK---------------DSLIKFYEKKDV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LFVA-----GLEDA--NVPSEYHINQAENLLKLANHPNYKIV--------------------------------------------------------------------------RCMGTGHLIEPPYTICNKSHGSFGTPYFSNFGGSKIPH--CRN----Q--ENVWKGILQFLQQNL----------------------------------------1220
1221 -------------------------------------LDIYLPK-ESK-------D-------S---YP-----V-VIH----T-------Y---------------------------------------------------------G--------------------S---------AWSM----------------------------------------NNSKGSADLNTICAAL--------LKA-GYA-----V----------------------------------------VT------P-N---HR--S----AS-----------------DAVYPAQL--------------------HD--LKAV----------------------------------------------V-----------------------------R--FVR---G-NAAKYK-------------------------------------F-------DTN--------------------------------------------------------F----V-AV--S-G--FS-----------------SG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------H-L--------------------------------------------SSLVATTCGLKEGKSGSVTVDLVGDLGEFNSFSSCIDA-------------A--TLW------------------------------------------S-----PPTDIYT-----------------M------------------------------------------------------------NPINN----------------------------------------------FMGSGTYE---GAF---IG------AEREGNKDKWM---------VASSP----Y---Y-------------------------------------------------A--SDD-DP--------------------------------------------P------------------------------------------------------------II--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LF-H-----GTSDQ--IVNK-EQSE-----------ELY-DS-L-----KAH-----------------NV-------V-------------TELVSV--SG-------------G------------------------------------THG------------------------------------------------------------------1221
1222 --------------------------------IQIRNVKFPTMDGLTLHGFIATP---TNTLPKGV----------ILF----C-------H---------------------------------------------------------P--------------------F---------------------------------------------------------------------------------------------------------------------------------------------------KSTGRIALFQCQGLLNA----GFAVFAFDFRNHGESDTDPRYQSIHWLSQYELND-TRSAI----------------------------------------------------------------------------Q--YL--------RTQPELSVLP-------------------------------------------------------------------------------------------------------L-GM--L-G--MS-----------------RG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GT--ALAVAAKDPEI--------------QFVACEGAFL---------------NEELFLD-----------------HAIRWGER-----------FLPPLF---IQIVPTSEVIRAFRIMIWYSQRRQGCRYINLKPRVKGLKNR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LFFT-----GEKDQ--SVVPRM---TQLIVKRI---PDAHIT--------------------------------------------------------------------------VCSL-----------------------------PGAIHNAGRF----AQLEKFDSTLIDFFSRMV----------------------------------------1222
1223 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GYW-----V----------------------------------------LR------I-D---FR-GQGDSSDN-----------------------------CDPGLGRTL---AQDLED--LSTV----------------------------------------------Y-----------------------------Q---TVSD-RSL-----RVQLY----------------------------------------KTS------------------------------------------------------TIS----LDVV--V-A--HS-----------------RG-----------------------------S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-AMFKFCL-----K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LHAAESPLPSHLINCAGRYD----------------------------GRGLIERCTRLHPHWQAEGGFWANGPRNGEYKDFWIP-----------------LSETYSIA-GVCVPEFATIPQTCS-VM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SC-Y-----GMCDH--IVPISAASNYARLFE--GRHSLKLIE----------------------------------------------------------NA--------------------------------------------------DHNY-----------------------------------------------------------------1223
1224 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GYY-----V----------------------------------------LR------I-D---FR-GLGDSEDC-----------------------------GNPAVGRTL---EQDVED--ISTV----------------------------------------------Y-----------------------------E--FAASD-ACV-----ELVGH-------------------------------------------------------------------------------------------------ALT----LDTI--V-A--HS-----------------RG-----------------------------V---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-SMFEFAL-----R-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HPV-RNLVNCCGRFE----------------------------ATGWLERVMRTYPNFSADKGIPCVALRHGERQEIWLP-----------------EPEVLSVA-TTQIDRYANIDVQTW-VV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SI-Y-----GTADA--VIPLTAAGNFANMFR--GRHTLEIVV----------------------------------------------------------GA--------------------------------------------------GHDF-----------------------------------------------------------------1224
1225 ----------------------------------------------------------KNEIG---DIYKRLAAQLASR----G-------Y---------------------------------------------------------A--------------------S-----------------------------------------------------------LRIDF----AGG-GD---SSQP--------------------------------------------------F------V-E---NN-----------------FD---------------DSVAD-----------ALK--------S----------------------------------------------I-----------------------------E--FL-------------------------------------------------ANYTGID-NN---------------------------------------------------------R----I-GV--L-G--YS-----------------QG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R-IAQVVV-------------------------------------A------------------------------------------RAP-K--VKAL--ATW----------------------------------------------------SSASSNGAKNLEIMFNHAEEAYAKDSAM-------VTMPWGTQLEFGKKFFTAM-------E-----------------------------------------------------------------------------------------------------------------NSRALDE---------------------------------------------------------------------------------------------------------------V---AKYKG--------------------------P-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AI-G-----GSEDT--VVSP----------------LL-------------------------------ARELV----------QHAG-STDATLRIIDG-----------------A----------------------------------DH---------------------------------------------------GFKIFADNKL------1225
1226 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------LALAF----YGY-ED---LPKE--------------------------------------------------M------K-E---FN-----------------LEYFE------------------------------E--------A----------------------------------------------V-----------------------------N--YM-------------------------------------------------LQHNQVK-GP---------------------------------------------------------G----I-GL--L-G--FS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-LCISMA-------------------------------------S------------------------------------------FLK-G--ITAT--AVI----------------------------------------------------NGSVANVGAVLRY----------KDVTI-------PPLGANVKRIKVNK-SGIG-------D---IIDV--------------------------------------------------LNSPL------------------------------------------------EGPDRQSFIP---------------------------------------------------------------------------------------------------------------L---EKAEC--------------------------R-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----GQDDH--NWKS----------------EFFAAE---------------------------GSKRL----------QAHG-KEKPEIICYPG-----------------A----------------------------------GHYIEPPFFPMCAASMHLLVGMP----VMWGGEPKAHCEA-------QTDAWKQIRAFFHRHL------1226
1227 -----------------------------------------------------------------------------------G-------L---------------------------------------------------------A--------------------M-----------------------------------------------------------FALAY----YGF-ED---LPKQ--------------------------------------------------L------K-D---LH-----------------LEYFE------------------------------E--------G----------------------------------------------V-----------------------------N--YM-------------------------------------------------LKHPMVK-GP---------------------------------------------------------G----I-GL--L-G--HS-----------------KA-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-LCISMA-------------------------------------S------------------------------------------FLK-G--IIAI--VTV----------------------------------------------------NGSVVNVGAALHY----------KDITI-------PPIGIDAKRAKIDS-AGVF-------D---IIDV--------------------------------------------------LDNPL------------------------------------------------EGEGCKSFIP---------------------------------------------------------------------------------------------------------------L---ERAEG--------------------------R-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----GQDDH--NWKS----------------EFYANE---------------------------GSKRL----------QAHG-KLKPEIICYPG-----------------A----------------------------------GHYIEPPYIPYCPVSMHFLVGHP----VMWGGEPKAHAAA-------QVDAWQQIQAFFHKHL------1227
1228 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------MALAY----YKY-DD---LPKV--------------------------------------------------I------D-I---LH-----------------LEYFE------------------------------E--------A----------------------------------------------V-----------------------------T--YL-------------------------------------------------LSHPQVK-GP---------------------------------------------------------G----V-GL--L-G--IS-----------------KG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-LSLSMA-------------------------------------S------------------------------------------FLK-G--ITAA--VVI----------------------------------------------------NGATVNVISTLYY----------KEESL-------PGLGMHLERIKVTK-DGFK-------D---IIDI--------------------------------------------------LNVPL------------------------------------------------EAPDQKSLIP---------------------------------------------------------------------------------------------------------------L---ERSDT--------------------------A-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-V-----GQDDH--NWKS----------------EFYARE---------------------------ASKRL----------QAHG-KEKPQIVCYPK-----------------T----------------------------------GHHIEPPYIPWSIAAPHSYFDKP----ILLGGEPRAHAMA-------QVDAWQRLQTFFHKHL------1228
1229 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------MALAY----NNY-ED---LPKD--------------------------------------------------M------D-I---IH-----------------LEYFE------------------------------E--------A----------------------------------------------V-----------------------------T--YL-------------------------------------------------LSHPQVT-GS---------------------------------------------------------G----V-GV--L-G--IS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-LGFAMA-------------------------------------S------------------------------------------FLK-N--ITAA--VII----------------------------------------------------NGSISNIGGNLQY----------KDETV-------PSVGINTKRVKRTK-DGLK-------D---IVDL--------------------------------------------------LNNPL------------------------------------------------EGPDQKSLIP---------------------------------------------------------------------------------------------------------------V---ERSDT--------------------------A-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-V-----GQDDH--NWKS----------------EFYARE---------------------------ASKRL----------QAHG-KEKPQIICYPE-----------------T----------------------------------GHHIEPPYFPLCKASLNSLVGGP----VIWGGEPRAHAMA-------QVDAWQQLQTFFHNHL------1229
1230 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------MALAY----HNY-ED---LPKG--------------------------------------------------L------E-I---LH-----------------LEYFE------------------------------E--------A----------------------------------------------V-----------------------------N--YL-------------------------------------------------LDHPQVK-GL---------------------------------------------------------G----V-GL--L-G--NS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-LCLSMA-------------------------------------S------------------------------------------FLK-G--ITAS--VII----------------------------------------------------NGSVANVGGTLHY----------KDEIL-------PPVGLDANRMRVTK-DGLA-------D---ILDV--------------------------------------------------LNSPL------------------------------------------------EGADQKSFIP---------------------------------------------------------------------------------------------------------------V---ERAES--------------------------A-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-V-----GLDDH--NWKS----------------EFYANE---------------------------ASKRL----------QAHG-REQPQIICYPM-----------------A----------------------------------GHYIEPPYFPMCRASLHTLVGGP----VIWGGEPRAHAMA-------QMDAWKQLQTFFHKHL------1230
1231 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------MALAY----HNY-ED---LPKG--------------------------------------------------L------E-I---LH-----------------LEYFE------------------------------E--------A----------------------------------------------V-----------------------------N--YL-------------------------------------------------LDHPQVK-GL---------------------------------------------------------G----V-GL--L-G--NS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-LCLSMA-------------------------------------S------------------------------------------FLK-G--ITAS--VII----------------------------------------------------NGSVANVGGTLHY----------KDEIL-------PPVGLDANRMRVTK-DGLA-------D---ILDV--------------------------------------------------LNSPL------------------------------------------------EGADQKSFIP---------------------------------------------------------------------------------------------------------------V---ERAES--------------------------A-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-V-----GLDDH--NWKS----------------EFYANE---------------------------ASKRL----------QAHG-REQPQIICYPM-----------------A----------------------------------GHYIEPPYFPMCRASLHTLVGGP----VIWGGEPRAHAMA-------QMDAWKQLQTFFHKHL------1231
1232 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------MALAY----YNY-ED---LPQG--------------------------------------------------I------E-T---LH-----------------LEYFE------------------------------E--------A----------------------------------------------V-----------------------------N--YL-------------------------------------------------LDHPEVK-GP---------------------------------------------------------G----V-GL--L-G--SS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-LCLSMA-------------------------------------S------------------------------------------FLK-G--ITAA--VII----------------------------------------------------NGSVANVGGALHY----------KDETL-------PPVGFEQSRIKLTR-DGLA-------D---ILDV--------------------------------------------------LNSPL------------------------------------------------EGPDQKSFIP---------------------------------------------------------------------------------------------------------------V---ERAEN--------------------------A-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-V-----GLDDH--NWKS----------------EFYANE---------------------------ASKRL----------QAHG-KEKPQIICYPG-----------------A----------------------------------GHYIEPPYFPLCQASLHTLVGGP----VIWGGEPRAHAMA-------QVDAWKQLQT------------1232
1233 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------MALAY----YNY-DD---LPKS--------------------------------------------------I------E-S---LH-----------------LEYFE------------------------------E--------A----------------------------------------------V-----------------------------N--CL-------------------------------------------------LSHPQVK-GP---------------------------------------------------------G----V-GL--L-G--IS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-LCLSMA-------------------------------------S------------------------------------------FLK-G--ITAT--VII----------------------------------------------------NGSVANVGGALHY----------KGETL-------PPVSSNLNRIRVTS-EGFA-------D---ILDV--------------------------------------------------LNSPL------------------------------------------------EGPDQKSFIP---------------------------------------------------------------------------------------------------------------V---ERAES--------------------------A-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-V-----GQDDH--NWKS----------------EFYASE---------------------------ASKRL----------QAHG-KERPQIICYPG-----------------A----------------------------------GHYIEPPYFPMCPASMHTLVGRP----VIWGGEPRAHAMA-------QVDAWKQLQAFFHKHL------1233
1234 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------MALAY----YNY-DD---LPKS--------------------------------------------------M------E-S---LH-----------------LEYFE------------------------------E--------A----------------------------------------------V-----------------------------N--CL-------------------------------------------------LSHPQVK-GP---------------------------------------------------------G----V-GL--L-G--IS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-LCLSMA-------------------------------------S------------------------------------------FLK-G--ITAT--VII----------------------------------------------------NGSVANVGGALHY----------KGETL-------PPVSSNLNRIRVTS-EGFA-------D---ILDV--------------------------------------------------LNSPL------------------------------------------------EGPDQKSFIP---------------------------------------------------------------------------------------------------------------V---ERAES--------------------------A-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-V-----GQDDH--NWKS----------------EFYASE---------------------------ASKRL----------QAHG-KERPQIICYPG-----------------A----------------------------------GHYIEPPYFPMCPASMHTLVGRP----VIWGGEPRAHAMA-------QVDAWKQLQAFFHKHL------1234
1235 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------MALAY----YNY-ED---LPKG--------------------------------------------------L------E-N---LH-----------------LEYFE------------------------------E--------A----------------------------------------------V-----------------------------N--YL-------------------------------------------------LNHPQVK-GP---------------------------------------------------------G----V-GL--L-G--IS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-LCLSMA-------------------------------------S------------------------------------------FLK-G--ISAA--VII----------------------------------------------------NGSVAYVGGNLHY----------KGEIM-------PPVGFNQNRIKMTK-DGFV-------D---IVEV--------------------------------------------------LNSPL------------------------------------------------EGPDQKSFIP---------------------------------------------------------------------------------------------------------------V---ERAEC--------------------------P-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-V-----GQDDH--NWKS----------------EFYANE---------------------------ASKRL----------QAHG-KAKPQVICYPG-----------------T----------------------------------GHYIEPPYFPLCPASLHTIVGAP----VIWGGEPRAHARA-------QVDAWQQLQTFFHKHL------1235
1236 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------MALAY----YNY-ED---LPKG--------------------------------------------------L------E-N---LH-----------------LEYFE------------------------------E--------A----------------------------------------------V-----------------------------N--YL-------------------------------------------------LNHPQVK-GP---------------------------------------------------------G----V-GL--L-G--IS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-LCLSMA-------------------------------------S------------------------------------------FLK-G--ISAA--VII----------------------------------------------------NGSVAYVGGNLHY----------KGEIM-------PPVGFNQNRIKMTK-DGFV-------D---IVEV--------------------------------------------------LNSPL------------------------------------------------EGPDQKSFIP---------------------------------------------------------------------------------------------------------------V---ERAEC--------------------------P-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-V-----GQDDH--NWKS----------------EFYANE---------------------------ASKRL----------QAHG-KAKPQVICYPG-----------------T----------------------------------GHYIEPPYFPLCPASLHTIVGAP----VIWGGEPRAHARA-------QVDAWQQLQTFFHKHL------1236
1237 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------LALAY----YNY-ED---LPKS--------------------------------------------------L------R-H---VH-----------------LEYFE------------------------------E--------A----------------------------------------------V-----------------------------N--YL-------------------------------------------------LNHPQVK-GP---------------------------------------------------------G----V-GL--L-G--IS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-LCLSMA-------------------------------------S------------------------------------------FLK-G--ISAA--VII----------------------------------------------------NGSVHNVWGTLHY----------KGETL-------PPVGFNQNRIKMTK-DGFV-------D---IVEV--------------------------------------------------LNSPL------------------------------------------------EGPDQKSFIP---------------------------------------------------------------------------------------------------------------V---ERAEC--------------------------P-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-V-----GQDDH--NWKS----------------EFYANE---------------------------ASKRL----------QAHG-KAKPQVICYPG-----------------T----------------------------------GHYIEPPYFPLCPASLHTFVGTP----VIWGGEPMAHARA-------QVDAWQQLQTFFHKHL------1237
1238 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------MALAY----YNY-ED---LPKT--------------------------------------------------M------E-T---LH-----------------LEYFE------------------------------E--------A----------------------------------------------V-----------------------------N--YL-------------------------------------------------LSHPEVK-GP---------------------------------------------------------G----V-GL--L-G--IS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-LCLSMA-------------------------------------S------------------------------------------FLK-G--ITAA--VVI----------------------------------------------------NGSVANVGGTLRY----------KGETL-------PPVGVNRNRIKVTK-DGYA-------D---IVDV--------------------------------------------------LNSPL------------------------------------------------EGPDQKSFIP---------------------------------------------------------------------------------------------------------------V---ERAES--------------------------T-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-V-----GQDDH--NWKS----------------EFYANK---------------------------ACKRL----------QAHG-RRKPQIICYPE-----------------T----------------------------------GHYIEPPYFPLCRASLHALVGSP----IIWGGEPRAHAMA-------QVDAWKQLQTFFHKHL------1238
1239 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------MALAY----YNY-ED---LPKT--------------------------------------------------M------E-T---LH-----------------LEYFE------------------------------E--------A----------------------------------------------M-----------------------------N--YL-------------------------------------------------LSHPEVK-GP---------------------------------------------------------G----V-GL--L-G--IS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-LCLSMA-------------------------------------S------------------------------------------FLK-G--ITAA--VVI----------------------------------------------------NGSVANVGGTLHY----------KGETL-------PPVGVNRNRIKVTK-DGYA-------D---IVDV--------------------------------------------------LNSPL------------------------------------------------EGPDQKSFIP---------------------------------------------------------------------------------------------------------------V---ERAES--------------------------T-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-V-----GQDDH--NWKS----------------EFYANE---------------------------ACKRL----------QAHG-RRKPQIICYPE-----------------T----------------------------------GHYIEPPYFPLCRASLHALVGSP----IIWGGEPRAHAMA-------QVDAWKQLQTFFHKHL------1239
1240 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------MALAY----YNY-DD---LPKN--------------------------------------------------M------E-T---MH-----------------MEYFE------------------------------E--------A----------------------------------------------V-----------------------------N--YL-------------------------------------------------RSHPEVK-GP---------------------------------------------------------G----I-GL--L-G--IS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-LGLAMA-------------------------------------S------------------------------------------FLK-G--ITAA--VVI----------------------------------------------------NGSVAAVGNTISY----------KDETI-------PPVTILRNQVKMTK-DGLK-------D---VVDA--------------------------------------------------LQSPL--------------------------------------------------VDKKSFIP---------------------------------------------------------------------------------------------------------------V---ERSDT--------------------------T-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-V-----GQDDH--NWKS----------------EFYADE---------------------------ISKRL----------QAHG-KEKPQIICYPA-----------------A----------------------------------GHYIEPPYFPLCSAGMHLLVGAN----ITFGGEPKPHAMA-------QLDAWQQLQTFFHKQL------1240
1241 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SCPQVK-GP---------------------------------------------------------G----I-GL--L-G--IS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-LGLAMA-------------------------------------S------------------------------------------FLK-G--ITAA--VVI----------------------------------------------------NGSVAAVGNTISY----------KDETI-------PPVTILRNQVKMTK-DGLK-------D---VVDA--------------------------------------------------LQSPL--------------------------------------------------VDKKSFIP---------------------------------------------------------------------------------------------------------------V---ERSDT--------------------------T-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-V-----GQDDH--NWKS----------------EFYADE---------------------------ISKRL----------QAHG-KEKPQIICYPA-----------------A----------------------------------GHYIEPPYFPLCSAGMHLLVGAN----ITFGGEPKPHAMA-------QLDAWQQLQTFFHKQL------1241
1242 ------RVRATLFLPPEPGPFPGII-------------------------------DLFGVGG---GLLEYRASLLAGK----G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------MALAY----YNY-DD---LPKS--------------------------------------------------I------E-T---MH-----------------MEYFE------------------------------E--------A----------------------------------------------V-----------------------------N--YL-------------------------------------------------RSHPEVK-GP---------------------------------------------------------G----I-GL--L-G--IS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-LGLAMA-------------------------------------S------------------------------------------FLK-G--ITAA--VVI----------------------------------------------------NGSVAAVGNTISY----------KDETI-------PPVSLLRNQVKMTK-DGLL-------D---VVEA--------------------------------------------------LQSPL--------------------------------------------------VDKKSFIP---------------------------------------------------------------------------------------------------------------V---ERSDT--------------------------T-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-V-----GQDDH--NWKS----------------EFYADE---------------------------ISKRL----------QAHG-KEKPQIICYPA-----------------A----------------------------------GH-------------------------------------------------------------------1242
1243 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------LALAY----FRF-ED---LPEY--------------------------------------------------L------N-D---VH-----------------LEYFE------------------------------E--------A----------------------------------------------V-----------------------------H--FM-------------------------------------------------LQHPKMK-GP---------------------------------------------------------S----V-GL--L-G--FS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-LCLSMA-------------------------------------S------------------------------------------FLK-N--ITAT--VLI----------------------------------------------------NACVANTIAPLHY----------KGMII-------PNLSNDPGKHAITE-SGLL-------D---FMDI--------------------------------------------------WNNPL------------------------------------------------EEPNHQSLIP---------------------------------------------------------------------------------------------------------------L---EKAQG--------------------------P-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----GMDDH--NWKS----------------ECYARI---------------------------ASERL----------QAHG-KDKPQIIYYPG-----------------T----------------------------------GHCIDPPYFPPSRASVHALLGQA----IFYGGEPKAHSRA-------QVDAWQQIQTFFHKHL------1243
1244 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-------------------------------------------------LQHPKMK-GP---------------------------------------------------------S----V-GL--L-G--FS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-LCLSMA-------------------------------------S------------------------------------------FLK-N--ITAT--VLI----------------------------------------------------NACVANTIAPLHY----------KGMII-------PNLSNDPGKHAITE-SGLL-------D---FMDI--------------------------------------------------WNNPL------------------------------------------------EEPNHQSLIP---------------------------------------------------------------------------------------------------------------L---EKAQG--------------------------P-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----GMDDH--NWKS----------------ECYARI---------------------------ASERL----------QAHG-KDKPQIIYYPG-----------------T----------------------------------GHCIDPPYFPPSRASVHALLGQA----IFYGGEPKAHSRA-------QVDAWQQIQTFFHKHL------1244
1245 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-------------------------------------------------LQHPKVK-GP---------------------------------------------------------G----V-GL--L-G--FS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-LCLSMA-------------------------------------S------------------------------------------FLK-G--ITAT--IVI----------------------------------------------------NACVANTLAPLHY----------KDMII-------PELSYDLEKYTITE-SGFL-------N---FVDI--------------------------------------------------WGNPL------------------------------------------------EKTNHQSLIP---------------------------------------------------------------------------------------------------------------L---EKAQG--------------------------P-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----SMDDH--NWKS----------------EVYARI---------------------------ASERL----------QAHG-KDRPQIIYYPG-----------------T----------------------------------GHCIDPPYFPLCRASVHAVLGQP----VFHGGEPKAHSNA-------QADAWQQIQTFFHKHL------1245
1246 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-------------------------------------------------LQHPKVK-GP---------------------------------------------------------S----I-AL--L-G--FS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-LCLSMA-------------------------------------S------------------------------------------FLK-G--ITAT--VLI----------------------------------------------------NACVANTVAPLHY----------KDMII-------PKLVDDLGKVKITK-SGFL-------T---FMDT--------------------------------------------------WSNPL------------------------------------------------EEHNHQSLVP---------------------------------------------------------------------------------------------------------------L---EKAQV--------------------------P-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----GMDDQ--SWKS----------------EFYAQI---------------------------ASERL----------QAHG-KERPQIICYPE-----------------T----------------------------------GHCIDPPYFPPSRASVHAVLGEA----IFYGGEPKAHSKA-------QVDAWQQIQTFFHKHL------1246
1247 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-------------------------------------------------LQHPKVK-GP---------------------------------------------------------N----V-GL--L-G--FS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-LCLSMA-------------------------------------S------------------------------------------FLK-G--ITAT--VLI----------------------------------------------------NSCVANTVAPLPY----------KDMII-------PSLGSDPKRYTINE-SGLL-------N---FMGI--------------------------------------------------WENPL------------------------------------------------EGSNQKSIIP---------------------------------------------------------------------------------------------------------------F---ERAQG--------------------------P-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----GMDDN--NWKS----------------SFYAQI---------------------------ASERL----------QANG-KDRPEIICYKG-----------------T----------------------------------GHCIEPPYFPVCRASVHAVLGQP----ICHGGEPEFQSRA-------QVDAWQRIQTFFHKHL------1247
1248 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-------------------------------------------------LQHPKVK-GP---------------------------------------------------------N----V-GL--L-G--FS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-LCLSMA-------------------------------------S------------------------------------------FLK-G--ITAT--VLI----------------------------------------------------NSCVANTVAPLPY----------KDMII-------PSLGSDPKRYTINE-SGLL-------N---FMGI--------------------------------------------------WENPL------------------------------------------------EGSNQKSIIP---------------------------------------------------------------------------------------------------------------F---ERAQG--------------------------P-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----GMDDN--NWKS----------------SFYAQI---------------------------ASERL----------QANG-KDRPEIICYKG-----------------T----------------------------------GHCIEPPYFPVCRASVHAVLGQP----ICHGGEPEFQSRA-------QVDAWQRIQTFFHKHL------1248
1249 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-------------------------------------------------LRHPQVK-GP---------------------------------------------------------N----I-GL--I-G--VS-----------------KG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-LCLSMA-------------------------------------A------------------------------------------FLKDN--ITAT--VLI----------------------------------------------------NACVANTLVPLYY----------KDLFV-------PELGCDQTK---NK-SGLM-------D---LRDM--------------------------------------------------WNNPL------------------------------------------------EEPNHQSLIP---------------------------------------------------------------------------------------------------------------L---EKAQG--------------------------P-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-V-----GMDDH--NWKS----------------DVYARI---------------------------ACERL----------QAHG-KDRPQIIYYPE-----------------T----------------------------------GHCIEPPYFPPPIATVHFVLGEA----VFNGGKPRAQSRA-------QLDAWQRIQTFFQKYL------1249
1250 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------T-----------------------------------------------------------LALAY----YNF-ED---LPKE--------------------------------------------------L------D-S---ID-----------------LTYFE------------------------------E--------A----------------------------------------------V-----------------------------C--YM-------------------------------------------------LQLSQVK-GP---------------------------------------------------------G----I-GL--L-G--IS-----------------LG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-ICLSMA-------------------------------------S------------------------------------------FLK-N--ISAT--VSI----------------------------------------------------NGSGLSGNKPIYY----------KQTCI-------PSLGYDLRRIKVTF-SGLL-------D---IVDT--------------------------------------------------RNDTV------------------------------------------------GGYENPSMIP---------------------------------------------------------------------------------------------------------------I---EKAQG--------------------------P-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----GQDDH--NWRS----------------ELYAQI---------------------------ASERL----------QAHG-KEKLKIISYPG-----------------T----------------------------------GHYIEPPYFPLCPASVHKILNKP----VLWGGEPRAHSKA-------QEDAWKQILTFFCKHL------1250
1251 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------T-----------------------------------------------------------FALAY----YNF-ED---LPKE--------------------------------------------------I------D-S---VD-----------------LDYFE------------------------------E--------A----------------------------------------------L-----------------------------C--YM-------------------------------------------------LQHSEVK-GP---------------------------------------------------------G----I-GL--L-G--IS-----------------LG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-ICLSMA-------------------------------------S------------------------------------------FLK-N--ISAT--VSI----------------------------------------------------NGSGFSGNKGIRY----------KQTFI-------PPLGHDLRRIKVAF-SGIL-------D---IVDI--------------------------------------------------RNDVV------------------------------------------------GGHENPSMIP---------------------------------------------------------------------------------------------------------------M---EKAQG--------------------------P-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----GQDDH--NWRS----------------ELYAQI---------------------------ASERL----------QAHG-KEKPQIISYPG-----------------T----------------------------------GHYIEPPYFPFCPASIQKLLNKP----VIWGGEPRAHSKA-------QEDAWKQILTFFCKHL------1251
1252 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------T-----------------------------------------------------------LALAY----YNF-ED---LPNN--------------------------------------------------M------D-N---IS-----------------LEYFE------------------------------E--------A----------------------------------------------V-----------------------------C--YM-------------------------------------------------LQHPQVK-GP---------------------------------------------------------G----I-GL--L-G--IS-----------------LG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-ICLSMA-------------------------------------S------------------------------------------FLK-N--VSAT--VSI----------------------------------------------------NGSGISGNTAINY----------KHSSI-------PPLGYDLRRIKVAF-SGLV-------D---IVDI--------------------------------------------------RNALV------------------------------------------------GGYKNPSMIP---------------------------------------------------------------------------------------------------------------I---EKAQG--------------------------P-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-V-----GQDDH--NWRS----------------ELYAQT---------------------------VSERL----------QAHG-KEKPQIICYPG-----------------T----------------------------------GHYIEPPYFPLCPASLHRLLNKH----VIWGGEPRAHSKA-------QEDAWKQILAFFCKHL------1252
1253 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------T-----------------------------------------------------------LALAY----YDF-DD---LPKK--------------------------------------------------F------D-M---IH-----------------LEYFE------------------------------E--------A----------------------------------------------L-----------------------------C--YM-------------------------------------------------LQHSQIK-GT---------------------------------------------------------R----I-GL--L-G--IS-----------------LG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-ICLSMA-------------------------------------S------------------------------------------FLK-N--ISAT--VSI----------------------------------------------------NGSGFSGHRVIHY----------KDSNI-------PPLGHDLRRVKVAF-SGLL-------D---IVDV--------------------------------------------------RNDII------------------------------------------------GGCENPCMIP---------------------------------------------------------------------------------------------------------------I---EKAQG--------------------------P-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----GQDDH--NWRS----------------ELYAQI---------------------------ASERL----------QAHG-KEKPQIISYPG-----------------T----------------------------------GHYIEPPYFPMCPASLHKLLDKP----VMWGGEPRAHSKA-------QVDAWKEILTFFTKHL------1253
1254 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------T-----------------------------------------------------------LAVAY----YSF-ED---LPKK--------------------------------------------------F------D-T---ID-----------------LDYFE------------------------------E--------A----------------------------------------------L-----------------------------C--YM-------------------------------------------------LQHAQIK-GP---------------------------------------------------------G----I-GL--L-G--IS-----------------LG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-ICLSMA-------------------------------------S------------------------------------------FLK-N--VSAT--VTI----------------------------------------------------NGSGFNGNKAMYY----------KENCI-------PPLGHDLRRVKVAF-SGLV-------D---IVDV--------------------------------------------------RNDIV------------------------------------------------GGCENPCMIP---------------------------------------------------------------------------------------------------------------I---EKAQG--------------------------P-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----GQDDH--NWRS----------------EFCAQI---------------------------ASERL----------QAHG-KEKPQIISYPG-----------------T----------------------------------GHYIEPPYFPMCPASLHKLLDKP----VMWGGEPRAHSKA-------QVDAWKKILTFFTKHL------1254
1255 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------T-----------------------------------------------------------LALAY----YDF-DD---LPTR--------------------------------------------------L------D-S---IH-----------------LDYFE------------------------------E--------A----------------------------------------------V-----------------------------S--YM-------------------------------------------------LQHTQVK-GP---------------------------------------------------------G----I-GL--L-G--IS-----------------LG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-ICLSMA-------------------------------------S------------------------------------------FLK-N--ISAT--VSI----------------------------------------------------NGSGVSGSPDIHY----------KQTCL-------PRLGYDLRRIKVAF-SGLL-------D---IVDM--------------------------------------------------RNDVV------------------------------------------------GGCEDPSMIP---------------------------------------------------------------------------------------------------------------V---DKAQG--------------------------P-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----GLDDH--NWRS----------------EFYAQL---------------------------ASDRL----------QAHG-KEKPQIISYPG-----------------A----------------------------------GHNIEPPYFPLCPASLHKLVDKP----VLWGGEPRAHSKA-------QVDAWKQILTFFCKHL------1255
1256 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------T-----------------------------------------------------------LALAF----YDF-ED---LPKE--------------------------------------------------L------N-V---IE-----------------VDYFE------------------------------E--------A----------------------------------------------V-----------------------------R--YM-------------------------------------------------LRHPKVK-GP---------------------------------------------------------D----I-GL--L-G--LS-----------------LG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-VCLIMA-------------------------------------S------------------------------------------FLN-N--VSAT--VSI----------------------------------------------------NGSAFSGNRHIKY----------KQTMI-------PPLGHDLRRMKVAF-SGIL-------D---IVDI--------------------------------------------------RNDAV------------------------------------------------GGCENPSMIP---------------------------------------------------------------------------------------------------------------I---EKAKG--------------------------P-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FV-A-----GQDDH--CWRS----------------ELYTQI---------------------------ASDRL----------QAHG-KERPQVLSYPG-----------------T----------------------------------GHYIEPPYFPMCPASLHKIVNEA----VIWGGEVKAHSKA-------QIDAWKQILFFFGKHL------1256
1257 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------T-----------------------------------------------------------LALAY----YQY-ED---LIQK--------------------------------------------------P------T-K---LH-----------------LEYFE------------------------------E--------A----------------------------------------------V-----------------------------N--YM-------------------------------------------------LQHTQVK-GP---------------------------------------------------------G----I-GL--L-G--YS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-LSLAMA-------------------------------------A------------------------------------------FLK-N--ITAV--ATI----------------------------------------------------NGPVANTVFPLCY----------KDKTI-------PSLIWDENRARVYD-NNIL-------D---YSDI--------------------------------------------------AFDPF------------------------------------------------KAPGNQSLIP---------------------------------------------------------------------------------------------------------------I---EKAEA--------------------------H-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-A-----GQDDH--IINS----------------KYYVTE---------------------------ACKYL----------QARG-KENVQTLIYPG-----------------A----------------------------------GHCIDPPFSPFYPIGTHPVLHKR----AVLGGELTAYSKA-------QVHAWLQIRAFFHKHL------1257
1258 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------LALAF----QGY-QD---LPKR--------------------------------------------------A------D-R---FH-----------------LEYFE------------------------------E--------G----------------------------------------------I-----------------------------D--FL-------------------------------------------------RQQPEVK-GQ---------------------------------------------------------K----I-GL--V-S--IS-----------------KS-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-LALSMA-------------------------------------T------------------------------------------FLP-D--IAAT--IWV----------------------------------------------------NGCNANTLVPVYY----------KDICV-------PPLLFDVKRTKITP-LGLV-------D---IGEV--------------------------------------------------MDDPM------------------------------------------------SKEGLPSVIP---------------------------------------------------------------------------------------------------------------I---ERAPG--------------------------S-------------------------FM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FV-V-----SEADR--NWRS----------------AYYAKL---------------------------ACDRL----------KAHG-KNNYQLVKYEK-----------------A----------------------------------GHFIEVPYMPFCLANFHGVAGQP----VFFGGEPKAHAEA-------QLDAWPKMINFFKKHL------1258
1259 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------LALAY----QNY-QD---LPKK--------------------------------------------------A------D-K---FH-----------------LEYFE------------------------------E--------G----------------------------------------------L-----------------------------D--FL-------------------------------------------------RRQPEVK-GQ---------------------------------------------------------K----I-GL--L-S--IS-----------------KS-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-LALSMS-------------------------------------T------------------------------------------FLP-D--ITAA--VWI----------------------------------------------------NGCNANSLIPLYY----------KDMYI-------PPLTLDFKKKKMTA-LGLV-------D---MLEV--------------------------------------------------VNDPM------------------------------------------------SKEGLPTVIP---------------------------------------------------------------------------------------------------------------I---ERASA--------------------------S-------------------------FM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-A-----SEADM--NWRS----------------VYHAKL---------------------------ACDRL----------KAHG-KNNYELVKYEK-----------------A----------------------------------GHFIEVPYMPFCLAAFHGVLEQP----VLFGGEPKAHSEA-------QVDAWQRIIIFFKRTL------1259
1260 APVREGRLRATLFLPPGPGPFPGIL-------------------------------DLYGSGG---GLVEYRASLLASR----G-------F---------------------------------------------------------V--------------------T-----------------------------------------------------------LALAY----LAF-ED---LPVF--------------------------------------------------P------E-V---LD-----------------LDYFG------------------------------E--------A----------------------------------------------V-----------------------------E--FL-------------------------------------------------KKQEQVQ-ST---------------------------------------------------------R----I-GV--I-G--IS-----------------KG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-LALAVA-------------------------------------T------------------------------------------FWP-G--IQAA--VSI----------------------------------------------------SGSGLNAFIPLQV----------KDLTI-------PAHPFDLNRVKVNSDSGFV-------D---YSEV--------------------------------------------------LDDPR------------------------------------------------DPATWPSRIP---------------------------------------------------------------------------------------------------------------V---EKSSS--------------------------K-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FL-S-----GQDDK--NWQS----------------ELYCRE---------------------------TVRRL----------QESG-RHV-EFYCYPG-----------------A----------------------------------GH-------------------------------------------------------------------1260
1261 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------M-----------------------------------------------------------LALAY----FAY-ED---LPEQ--------------------------------------------------L------Q-E---VD-----------------LDYFE------------------------------E--------A----------------------------------------------A-----------------------------N--LL-------------------------------------------------LAHPKIQ-KP---------------------------------------------------------G----I-GV--L-S--TS-----------------KG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-IGLAMA-------------------------------------C------------------------------------------YLK-Q--VVAT--VWI----------------------------------------------------NGTNAIFEFPLKY----------RDMVM-------KPIPSFLERMQMDI-SGAV-------R---LRHY--------------------------------------------------KGDPR------------------------------------------------EKLNQQSVLP---------------------------------------------------------------------------------------------------------------V---EKARG--------------------------P-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-I-----SGDDE--CFNS----------------RQYAEQ---------------------------ALDQL----------RSHG-RSSGRMLVYPG-----------------A----------------------------------GHLLESPHGPSCYASWSYSLSAP----ILWGGDRVAHGAA-------QEHSWAEIQKFFRQHL------1261
1262 VPIREGRIRGALFLPPGEGPFPGLL-------------------------------DLFGGIG---GLVEYRASLLAVR----G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------LALAY----FAY-DD---LPKQ--------------------------------------------------L------E-E---VD-----------------LEYFE------------------------------E--------A----------------------------------------------A-----------------------------N--LL-------------------------------------------------LAHPKVQ-KP---------------------------------------------------------G----I-GV--I-S--VS-----------------KG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-IGLAMA-------------------------------------C------------------------------------------YLK-Q--VAAT--VCI----------------------------------------------------NGANAIHEFPLRY----------RDLVI-------TPIPSFPERMQVNA-AGAV-------R---IRHF--------------------------------------------------KGDPR------------------------------------------------DERNQHSVLP---------------------------------------------------------------------------------------------------------------V---EKARG--------------------------P-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FV-V-----GEADE--CFNS----------------KEYAEQ---------------------------ALDQL----------RRHG-KSSGRMLSYPG-----------------A----------------------------------GH-------------------------------------------------------------------1262
1263 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------LALAY----FAY-ED---LPSD--------------------------------------------------L------L-E---ID-----------------LEYFE------------------------------E--------A----------------------------------------------A-----------------------------N--LL-------------------------------------------------LAHPKVQ-TP---------------------------------------------------------G----I-GV--I-S--VS-----------------KG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-IGLAMA-------------------------------------C------------------------------------------FLK-Q--VVAT--IWI----------------------------------------------------NGTNAIFEFPLRY----------KDTVI-------TPIPTFVERMQLDI-SGAM-------R---LRHY--------------------------------------------------KGDPW------------------------------------------------DELNQQSVLP---------------------------------------------------------------------------------------------------------------I---EKALG--------------------------S-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----GENDE--CMNS----------------KEYAEQ---------------------------ALHQL----------RSHG-RNNGRMLLYPG-----------------A----------------------------------GHLIEPPYSPLCYASPNKNFSLP----LLWGGDPAAHAAA-------QEHSWGEILKFFRQHL------1263
1264 VQIREGRVRGALFLPPGEGPFPGVI-------------------------------DLFGGRG---GLVEFRASLLAAR----G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------LALAY----FAY-ED---LPSD--------------------------------------------------L------L-E---ID-----------------LEYFE------------------------------E--------A----------------------------------------------A-----------------------------N--LL-------------------------------------------------LAHPKVQ-TP---------------------------------------------------------G----I-GV--I-S--VS-----------------KG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-IGLAMA-------------------------------------C------------------------------------------FLK-Q--VVAT--IWI----------------------------------------------------NGTNAIFEFPLRY----------KDTVI-------TPIPTFVERMQLDI-SGAM-------R---LRHY--------------------------------------------------KGDPW------------------------------------------------DELNQQSVLP---------------------------------------------------------------------------------------------------------------I---EKALG--------------------------S-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----GENDE--CMNS----------------KEYAEQ---------------------------ALHQL----------RSHG-RNNGRMLLYPG-----------------A----------------------------------GH-------------------------------------------------------------------1264
1265 --IREGRVRGALFLPPGEGPFPGIV-------------------------------DLFGGRG---GLTEFRASLLATH----G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------LALAY----FLY-ED---LPKE--------------------------------------------------L------E-E---ID-----------------LEYFE------------------------------E--------A----------------------------------------------A-----------------------------N--WL-------------------------------------------------LAHPKIQ-KP---------------------------------------------------------G----I-GV--I-S--VS-----------------KG-----------------------------V---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-IALAMA-------------------------------------C------------------------------------------FTK-Q--VVAT--ICI----------------------------------------------------NGPNAIYEFPLRY----------KDLVI-------TPIPSFMERVQIDV-LGAM-------R---LRYY--------------------------------------------------KGDAR------------------------------------------------DELNRKSVLP---------------------------------------------------------------------------------------------------------------I---EKAQG--------------------------A-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----GDGDE--CLNS----------------REYAEQ---------------------------ALDQL----------RSHG-RNNGRMLVYPG-----------------A----------------------------------GH-------------------------------------------------------------------1265
1266 --IQEGRVRGALFLPPGKGPFPGII-------------------------------DLFGLIG---GLVEFRASLLASH----G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------LALAY----FAY-ED---LPEK--------------------------------------------------P------Q-E---VD-----------------LEYFE------------------------------E--------A----------------------------------------------A-----------------------------N--FL-------------------------------------------------LSHPKIQ-QP---------------------------------------------------------G----I-GV--I-S--TS-----------------KG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-IGLAMA-------------------------------------C------------------------------------------YLK-Q--VIAT--VCI----------------------------------------------------NGPTTITIFPLRY----------QDLVM-------TPIHPALERIQVHD-SGAL-------L---FRYT--------------------------------------------------TQYLH------------------------------------------------NKLNSQNILP---------------------------------------------------------------------------------------------------------------V---EKAQG--------------------------K-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----GENDE--CLDS----------------KLHAQK---------------------------AMDRL----------QRHG-RSSGRMLAYPG-----------------A----------------------------------GH-------------------------------------------------------------------1266
1267 --IQEGRVRGALFLPPGKGPFPGII-------------------------------DLFGVIG---GLVEFRASLLASH----G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------LALAY----FAY-KD---LPEK--------------------------------------------------L------Q-E---VD-----------------LEYFE------------------------------E--------A----------------------------------------------A-----------------------------N--FL-------------------------------------------------LSHPKIQ-QP---------------------------------------------------------G----I-GV--I-S--TS-----------------KG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-IGLAMA-------------------------------------C------------------------------------------YLK-Q--VIAT--VCI----------------------------------------------------NGATTTTAVPLRY----------QDLVV-------TPIQQALERMEVHV-SGAV-------C---FRHT--------------------------------------------------TQYLQ------------------------------------------------NK----NILP---------------------------------------------------------------------------------------------------------------V---EKAQG--------------------------K-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----GENDE--LLDS----------------KLHAQR---------------------------AMDRL----------RRHG-RSSGRMLAYPG-----------------A----------------------------------GH-------------------------------------------------------------------1267
1268 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------T-----------------------------------------------------------LALAY----CDY-ED---LPSQ--------------------------------------------------P------E-K---TD-----------------LEYFE------------------------------E--------A----------------------------------------------V-----------------------------N--FL-------------------------------------------------LRHPKVL-GP---------------------------------------------------------G----V-GI--V-S--IS-----------------KG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-IGLSMA-------------------------------------I------------------------------------------HLK-Q--VTAT--VLI----------------------------------------------------NGPNFVIRIPQVY----------RGQIS-------QPLPFSPQLLSINA-LGLA-------E---FQHN--------------------------------------------------FEEAR------------------------------------------------NEANENFLLP---------------------------------------------------------------------------------------------------------------I---EKAQG--------------------------H-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----GEDDK--NLNS----------------KAYAKQ---------------------------ATEQL----------RRNG-KNNWTLLSYPG-----------------A----------------------------------GHLLEAPYSPLCCASKISSLHLF----IHWGGEVTPHAIA-------QEHSWKEIKKFLRKHL------1268
1269 IQVREGHIRGTLFLPPGEGRFPGVI-------------------------------DLFAGVG---GLIESRASLLASH----G-------F---------------------------------------------------------A--------------------T-----------------------------------------------------------LALAY----CDY-ED---LPSQ--------------------------------------------------P------E-K---TD-----------------LEYFE------------------------------E--------A----------------------------------------------V-----------------------------N--FL-------------------------------------------------LRHPKVL-GP---------------------------------------------------------G----V-GI--V-S--IS-----------------KG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-IGLSMA-------------------------------------I------------------------------------------HLK-Q--VTAT--VLI----------------------------------------------------NGPNFVIRIPQVY----------RGQIS-------QPLPFSPQLLSINA-LGLA-------E---FQHN--------------------------------------------------FEEAR------------------------------------------------NEANENFLLP---------------------------------------------------------------------------------------------------------------I---EKAQG--------------------------H-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----GEDDK--NLNS----------------KAYAKQ---------------------------ATEQL----------RRNG-KNNWTLLSYPG-----------------A----------------------------------GH-------------------------------------------------------------------1269
1270 --VQEGHLRGALFLPPGEGRFPGVI-------------------------------DLFADIG---GLIEYRASLLASH----G-------F---------------------------------------------------------A--------------------A-----------------------------------------------------------LALAY----CDY-ED---LPLH--------------------------------------------------P------E-K---IE-----------------LEYFE------------------------------E--------A----------------------------------------------V-----------------------------N--FL-------------------------------------------------LRHPKVL-GP---------------------------------------------------------G----I-GI--V-S--IS-----------------KG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-IGLSMA-------------------------------------I------------------------------------------HLK-Q--VTAT--VLI----------------------------------------------------NGPNFVFSTPQVY----------RGQIS-------QPLSFSPQLVSINA-LGLA-------Q---FQYC--------------------------------------------------FEEAR------------------------------------------------SKASETFFFP---------------------------------------------------------------------------------------------------------------I---EKAQG--------------------------H-------------------------FL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----GEDDK--SINS----------------KAYAEQ---------------------------ATEQL----------RRNG-KDNWTLLSYPG-----------------A----------------------------------GH-------------------------------------------------------------------1270
1271 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------LALAF----FAY-ED---LPKG--------------------------------------------------L------T-Q---LD-----------------LDYFE------------------------------E--------A----------------------------------------------V-----------------------------E--LL-------------------------------------------------LRHPKVR-GP---------------------------------------------------------G----L-GV--I-G--VS-----------------KG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-VALAMA-------------------------------------A------------------------------------------FLP-Q--VVAT--VWI----------------------------------------------------NGTTFLYGNPLHY----------KGLRI-------PSIPYQTERMLFTE-LGAM-------D---NSAI--------------------------------------------------FADPR------------------------------------------------SPAYSSSAIP---------------------------------------------------------------------------------------------------------------V---EKIQG--------------------------K-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FV-V-----GEADR--SFNS----------------KLFAQL---------------------------ATERL----------PQDA-YR---LLSYPG-----------------A----------------------------------GHLIEPPGSPLCSISSLRGSPRP----VVWGGEPVPHARA-------QQHSWQEIVQFLELHL------1271
1272 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------L-------------------------------------------------LGHPKVR-GP---------------------------------------------------------G----L-GV--I-G--VS-----------------KG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-VALAMA-------------------------------------A------------------------------------------FLP-Q--VVAT--VWI----------------------------------------------------NGTTFLYGNPLHY----------KGLRI-------PSIPYQTERMLFTE-LGAM-------D---NSAI--------------------------------------------------FADPR------------------------------------------------SPAYSSSAIP---------------------------------------------------------------------------------------------------------------V---EKIQG--------------------------K-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FV-V-----GEADR--SFNS----------------KLFAQL---------------------------ATERL----------PQDA-YR---LLSYPG-----------------A----------------------------------GHLIEPPGSPLCSISSLRGSPRP----VVWGGEPVPHARA-------QQHSWQEIVQFLELHL------1272
1273 --IKTGRVRGALFVPPGPGPFPGVI-------------------------------DLFGGSG---GLFEFRASLLASK----G-------F---------------------------------------------------------V--------------------V-----------------------------------------------------------LALAY----FAY-DD---LPQS--------------------------------------------------L------T-E---VN-----------------LEYFQ------------------------------E--------A----------------------------------------------S-----------------------------I--LL-------------------------------------------------LNHTKVR-GP---------------------------------------------------------G----L-GV--I-G--LS-----------------KG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-IALAMA-------------------------------------T------------------------------------------FLP-Q--IVAA--VCI----------------------------------------------------NGATYMNGAPLCF----------RDVHI-------PAIPYSSERIVITE-MEGM-------A---TLHV--------------------------------------------------WGDPH------------------------------------------------DKGHQASAIP---------------------------------------------------------------------------------------------------------------V---EKALG--------------------------P-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FV-V-----GEDDE--SLKS----------------KLYAEI---------------------------AIARA----------KKNG-KNNCTLLSYPG-----------------A----------------------------------GH-------------------------------------------------------------------1273
1274 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------A-----------------------------------------------------------LALAH----FAF-DD---LPKT--------------------------------------------------I------G-V---TN-----------------LDYFE------------------------------E--------A----------------------------------------------A-----------------------------D--WL-------------------------------------------------LSLPNVR-SH---------------------------------------------------------G----V-GV--L-G--TS-----------------YG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-LALCMA-------------------------------------S------------------------------------------YMS-K--VSAV--TVT----------------------------------------------------SSLIAVTIAPLHY----------KDGVL-------PCVHYDLNRAVFSN-EGYI-------D---TRNV--------------------------------------------------IEDCT------------------------------------------------QEPGLKACIQ---------------------------------------------------------------------------------------------------------------V---EKAQC--------------------------P-------------------------IM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FV-A-----GEDDL--MTKS----------------VLYANQ---------------------------AIGRM----------KAHG-KTNYTLLQYPR-----------------T----------------------------------GHLIEPPYTPHCGLTYHG----VSQMCILAGGEPKSHAAA-------QEDSWHKILDFFKTHV------1274
1275 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------LALAF----FAY-DD---LPKE--------------------------------------------------M------V-N---VD-----------------LDYFE------------------------------E--------A----------------------------------------------A-----------------------------D--WL-------------------------------------------------LSLPNVQ-SH---------------------------------------------------------G----V-GV--V-A--TS-----------------KG-----------------------------V---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-IALSMA-------------------------------------A------------------------------------------HMD-K--INFL--QTG----------------------------------------------------C-----------------------------------CC---------SR-HQWL-------H---GCNC--------------------------------------------------CSTAL------------------------------------------------QGHSLPLC-T---------------------------------------------------------------------------------------------------------------V---EKARC--------------------------P-------------------------IM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FV-A-----AEDDL--STKA----------------VFFANQ---------------------------AIDRM----------KAHG-KTNYTLLQYPK-----------------A----------------------------------GHLIEPPYSPHCALYYHR----VFDWCMLAGGEPRSHAAA-------QEDSWHKILSFFRTHV------1275
1276 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E--------A----------------------------------------------A-----------------------------D--WL-------------------------------------------------LGHPKVQ-NH---------------------------------------------------------G----V-GL--V-G--TS-----------------KA-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-IVLAMA-------------------------------------T------------------------------------------YMK-Q--LSDP--S-----------------------------------------------------------------------------------------------------AV-DTYL-------------------------------------------------------------------------------------------------------------------------------S---------------------------------------------------------------------------------------------------------------V---EKSHC--------------------------P-------------------------IM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FV-T-----GEDDM--NIPS----------------VFHANK---------------------------AIARM----------KAHG-KTNYTLLKYPG-----------------T----------------------------------GHLIEPPYTPHCGFYFHP----AFRVYVYAGGESKAHTAA-------QEDSWSKILDFLRKNV------1276
1277 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------C--------------------V-----------------------------------------------------------LALAF----FLY-ED---LTTV--------------------------------------------------Y------T-D---IT-----------------ADYFI------------------------------E--------A----------------------------------------------S-----------------------------K--WF-------------------------------------------------SGLPRVL-ST---------------------------------------------------------G----I-GV--I-A--LS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-YALEMT-------------------------------------R------------------------------------------HSS-T--VKAV--VLI----------------------------------------------------NAVSFYSDVPLKF----------SKGDI-------PCTEFHFDGIVPTI-NGL--------------------------------------------------------------------------------------------------------------------------------D---------------------------------------------------------------------------------------------------------------F---RKAHQ--------------------------PSDDFFIKAWESNAS-----------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CI-V-----GEDDH--CLNP----------------QL-TDQ---------------------------FLKLV----------PKEH-KHRFYVIKYPG-----------------A----------------------------------GHLIEPPFAPHCVASFHK----LMGCIYDWGGETKHHSYA-------QEDSWRRILQFFTTHL------1277
1278 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------C--------------------V-----------------------------------------------------------LALAF----FLY-ED---LTTD--------------------------------------------------Y------T-T---IT-----------------ADYFI--VRGIPKYNYFRKQTA-----------ANE--------A----------------------------------------------T-----------------------------K--WF-------------------------------------------------SGLPRVL-ST---------------------------------------------------------G----I-GV--I-G--LS-----------------KS-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T-FALEMA-------------------------------------R------------------------------------------HSS-A--VKAV--VLI----------------------------------------------------NAESFHSDVPLKF----------SKGDI-------PCAEFNFDGIVPTK-NGL--------------------------------------------------------------------------------------------------------------------------------D---------------------------------------------------------------------------------------------------------------F---TKTQE--------------------------PSDDFFIKAWESNAS-----------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CI-V-----GEDDH--CLNP----------------QL-TYR---------------------------FLNLV----------PKEQ-KHRFHVIKYPG-----------------A----------------------------------GHLIEPPFAPHCVASFHKHLECISGCIFDWGGETKAHSYA-------QEDSWRQIIQFFTTHL------1278
1279 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------C--------------------V-----------------------------------------------------------FALPF----FAY-ED---LPKS--------------------------------------------------L------P-D---VS-----------------LDYLI------------------------------E--------S----------------------------------------------T-----------------------------E--WF-------------------------------------------------AGLPKVK-KD---------------------------------------------------------G----I-GI--I-G--LS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-YALELC-------------------------------------R------------------------------------------QVS-Q--IKAV--VLV----------------------------------------------------NGVSFYSDVPLKY----------SKGDI-------MNSEFKFDKIITTP-EGI--------------------------------------------------------------------------------------------------------------------------------D---------------------------------------------------------------------------------------------------------------I---KECYK--------------------------PTDDEFIKAWESEAS-----------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CI-N-----GEDDG--SLDY----------------KT-NER---------------------------FLELV----------PEDQ-KHRFQLIKYPR-----------------A----------------------------------GHLIEPPYTPHCRYSFHK----VFQFDFLWGGETKGHSVA-------QEDSWRRILDFFSHHL------1279
1280 -EVKVGRVRGTLIKPKGRGPFPGII-------------------------------DMYGALG---GILEMRASLLANY----G-------Y---------------------------------------------------------A--------------------V-----------------------------------------------------------LALGY----CRY-KD---LPDN--------------------------------------------------I------L-E---ID-----------------LDYFE------------------------------E--------S----------------------------------------------I-----------------------------N--WF-------------------------------------------------TGQECVM-TG---------------------------------------------------------G----I-GT--I-G--LS-----------------KG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-LAVTMA-------------------------------------V-----------------------------------------------------------------------------------------------------------------------------------------------------YDNSKLVII--DDNA-------C---CLEI--------------------------------------------------VDDPV------------------------------------------------D----EAVFD---------------------------------------------------------------------------------------------------------------F---SRVKA--------------------------E-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WI-A-----VGDDL--LCKT----------------PFYAEE---------------------------AIKQI----------RSLN-KSNYRYLYYPG-----------------A----------------------------------GH-------------------------------------------------------------------1280
1281 FEVKVGRVRGTLIKPKGSGPFPGII-------------------------------DMYGALG---GLLEMRASLLANY----G-------Y---------------------------------------------------------A--------------------V-----------------------------------------------------------LALGY----CRY-KD---LPEN--------------------------------------------------F------L-R---ID-----------------LDYFE------------------------------E--------S----------------------------------------------I-----------------------------N--WF-------------------------------------------------TSQECVM-TG---------------------------------------------------------G----I-GT--I-G--LS-----------------KG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-LAVTMA-------------------------------------V------------------------------------------YFPDK--KGGE--FPK----------------------------------------------------LGTSDLNITTFNL----------SNVVE-------NPGRYDNSKLVII--DGNA-------C---SLEL--------------------------------------------------LDDPV------------------------------------------------D----EAVFD---------------------------------------------------------------------------------------------------------------F---SRVKA--------------------------E-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YI-A-----VGDDL--LCKT----------------PFYAEE---------------------------AIKRI----------RSLN-KSNYRYLYYPG-----------------A----------------------------------GH-------------------------------------------------------------------1281
1282 -----------------------------------------------------------------------------------G-------Y---------------------------------------------------------A--------------------V-----------------------------------------------------------LALAF----CGY-QD---LPEM--------------------------------------------------F------L-Q---ID-----------------LDYFE------------------------------E--------S----------------------------------------------I-----------------------------N--WF-------------------------------------------------TDQDFVM-PG---------------------------------------------------------G----I-GT--I-G--LS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-IAVAMA-------------------------------------T------------------------------------------YFPEK--VKAV--VSI----------------------------------------------------NGAHMHTYSAMKF----------RGQTL-------PYTGYETTKLIVK--DGNA-------S---CLEL--------------------------------------------------VDDPV------------------------------------------------E----QAVFD---------------------------------------------------------------------------------------------------------------F---SRVKA--------------------------E-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------WI-A-----AGDDL--NWKS----------------QFYAEE---------------------------AVKIL----------KTLN-MSNYQYLYYPE-----------------A----------------------------------GHLIEPSNTPFCALSYHKLLGLN----LLWGGKAKAHTRA-------QEDSWKRILQFFQKKL------1282
1283 --IRENGLIATFFYNENKKTNPGII-------------------------------VLGGSEG---GLNEYLAALLASH----N-------F---------------------------------------------------------S--------------------V-----------------------------------------------------------LALAY----FGI-DN---LPKQ--------------------------------------------------L------V-E---IP-----------------LEYIK------------------------------T--------A----------------------------------------------I-----------------------------E--WM-------------------------------------------------KQREEVT-KN---------------------------------------------------------W----L-GI--H-G--TS-----------------RG-----------------------------S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-LALLSA-------------------------------------C------------------------------------------FFQ-E--INAV--ASL----------------------------------------------------NGSAIALSGIVPW----------SDATT-----LPPAWTYKGTAL-----------------------P--------------------------------------------------YASPI--------------NPISVA---LECRKMFEEHRGMPYRKWYNALTSDSKVVENATIP---------------------------------------------------------------------------------------------------------------V---EKING--------------------------D-------------------------VL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-A-----GEEDE--A-DI----------------VRLSKK---------------------------AINRL----------DTFHSPHFYKQLVYKG-----------------A----------------------------------GH-------------------------------------------------------------------1283
1284 IEVKEGGLVGSLFLPFSQAPLPVII-------------------------------VLGGSNG---GLSENRARLIASN----G-------F---------------------------------------------------------A--------------------V-----------------------------------------------------------LALGY----FGL-EG---LPDN--------------------------------------------------L------E-N---IP-----------------LEYFE------------------------------R--------A----------------------------------------------F-----------------------------E--WL-------------------------------------------------SQRDDIL-GN---------------------------------------------------------R----V-GI--Y-G--IS-----------------RG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-LALLIG-------------------------------------C------------------------------------------LFP-E-KVQAI--VAA----------------------------------------------------LPSYVVFGGL---------------SIE-----RVPAWQYRGEPL-----------------------I--------------------------------------------------PDAPVPRCDLSYGKGQNPEDPLTISTSYLQGMQEFPED--------YAA----------AEIP---------------------------------------------------------------------------------------------------------------V---EKLQA--------------------------S-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LI-S-----GGDDQ--MWPS----------------TLFASK---------------------------IMDRL----------KAKQSQITRIHLDYPL-----------------A----------------------------------GH-------------------------------------------------------------------1284
1285 -----------------------------------------------------------------------------------G-------Y---------------------------------------------------------A--------------------A-----------------------------------------------------------LAVAY----FDW-NGSHLLPNQ--------------------------------------------------L------A-N---VP-----------------LEPCL------------------------------D--------A----------------------------------------------M-----------------------------K--WL-------------------------------------------------ANHSTVD-AN---------------------------------------------------------K----L-GI--I-G--YS-----------------KG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-LALLLA-------------------------------------S------------------------------------------KLE-KVDLQAL--VTL----------------------------------------------------SPSSHIFAGF--S----------MEEAL-----NTSSWSYQGAPV-----------------------P--------------------------------------------------Y-LPYPKTN----------HPLYETNLY--------------DLHSEAIKQSSKEIWEQARIS---------------------------------------------------------------------------------------------------------------V---EKIES--------------------------P-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IV-T-----GVQDS--TWP--------------------SVE---------------------------MVDTI----------EVQTSSKLIKKVILEE-----------------A----------------------------------GHDFTLPYLPI----------------------------------------------------------1285
1286 -----------------------------------------------------------------------------------G-------Y---------------------------------------------------------A--------------------A-----------------------------------------------------------LAVAY----FDW-NGSHLLPNQ--------------------------------------------------L------A-N---VP-----------------LEPCL------------------------------D--------A----------------------------------------------M-----------------------------K--WL-------------------------------------------------ANHSTVD-SN---------------------------------------------------------K----L-GI--I-G--YS-----------------KG-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E-LALLLA-------------------------------------S------------------------------------------KLE-KTDLQAL--VTL----------------------------------------------------SPSSHIFAGF--S----------MEEAL-----NTSSWSYQGVPV-----------------------P--------------------------------------------------Y-LPYPKTN----------HPLYETNLY--------------HLHSEAIKQSSQEIWEQARIS---------------------------------------------------------------------------------------------------------------V---EKIES--------------------------P-------------------------ML--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VV-T-----GMKDS--TWP--------------------SVE---------------------------MVDTI----------EAQTSSKLIKKVILQE-----------------A----------------------------------GHDFTLPYLPI----------------------------------------------------------1286
1287 --VEKHGIHGTLFIPPGQGPFPAVL-------------------------------TLFGSYP---GTMEFKAALLSSY----G-------F---------------------------------------------------------V--------------------T-----------------------------------------------------------LALAF----YGV-PG---LPSL-ES-----F----------------------------------------HS------W-K---VD-----------------LGYFE------------------------------K--------A----------------------------------------------F-----------------------------E--YL-------------------------------------------------SNIQEVD-DTK--------------------------------------------------------G----F-GV--I-C--IS-----------------FS-----------------------------T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Q-IMLAAA-------------------------------------S------------------------------------------FLP-K--IRCV--VWI----------------------------------------------------NGTIHTSYINLMY----------KGQEM-------PISQAHSEPGNFIL-NGVV-------KGRQLFLT--------------------------------------------------FQDPF------------------------------------------------CPEAVAGLTD---------------------------------------------------------------------------------------------------------------F---YKRKG--------------------------I-------------S-----------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FV-V-----GLSDE--SLHS----------------ELWANQ---------------------------AEKLF----------KLAG-HPSYKILRYPG-----------------A----------------------------------GH-------------------------------------------------------------------1287
1288 LTVEKHGIHGTLFIPPGQGPFPAVV-------------------------------TLFGGVP---GTMEYKAAILSSH----G-------F---------------------------------------------------------V--------------------T-----------------------------------------------------------FALAY----YGS-PG---LQTS-LD-----L----------------------------------------TE------N-G---LD-----------------LSYFD------------------------------K--------V----------------------------------------------F-----------------------------D--FL-------------------------------------------------SSLPSVD-SSR--------------------------------------------------------G----F-GL--I-C--IS-----------------FS-----------------------------T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------F-ICLAAA-------------------------------------A------------------------------------------WLS-R--ISCV--VWI----------------------------------------------------NGFLHTTMLDLVY----------KEKKI----CSFPLNLLRYSDINIGE-DNIW-------KGRDLYTV--------------------------------------------------FHDPF------------------------------------------------DPNAKASLSG---------------------------------------------------------------------------------------------------------------F---YRRKD--------------------------V-------------S-----------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-S-----GLSDE--NVPS----------------ELMANQ---------------------------AEKLF----------KLAG-HPSYKILRYPG-----------------A----------------------------------GH-------------------------------------------------------------------1288
1289 --VEKHGIHGTLFIPPGQGPFPAVV-------------------------------TIFGGHP---GTFEFKAALLARH----G-------F---------------------------------------------------------V--------------------T-----------------------------------------------------------MALAF----FGS-PG---LAQIKQP-----V----------------------------------------DD------W-D---FD-----------------LDYFD------------------------------K--------A----------------------------------------------F-----------------------------D--FL-------------------------------------------------SSLSSVD-SSR--------------------------------------------------------G----F-GV--I-C--IS-----------------FS-----------------------------T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M-LVMAAA-------------------------------------S------------------------------------------CVD-R--IRCV--VWI----------------------------------------------------NGFIHVNCMRITY----------KGKKFGRCGDKYPFNYDYQ---SMIT-NDGL-------STRKFFPY--------------------------------------------------FSNPF--------------------------------------------------DSSESLPD---------------------------------------------------------------------------------------------------------------F---FRRKD--------------------------V-------------S-----------YL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FI-V-----GLADE--SVIA----------------ETWANQ---------------------------AEQLF----------QMTG-HPSYKILRYPG-----------------A----------------------------------GH-------------------------------------------------------------------1289
1290 KFIKYGRIRGILFCPPGNGPFPAVI-------------------------------TLYGGTK-KQLPIQDVSAILVNN----G-------Y---------------------------------------------------------V--------------------S-----------------------------------------------------------LALAY----FNV-DD---LPKV--------------------------------------------------Y------G-N---LD-----------------IEYFE------------------------------E--------A----------------------------------------------V-----------------------------V--FL-------------------------------------------------QNLPVVN-KS---------------------------------------------------------S----I-GV--Y-G--IS-----------------KG-----------------------------G---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-VALAMA-------------------------------------S------------------------------------------FLP-Q--IKSV--VSM----------------------------------------------------NGSLHSIGGDTKYNGVTIPKLVHKDETY----------------YKVSKYDTIV-------S---SFIY--------------------------------------------------AKIPL---------------------------------------------------NDQSLIP---------------------------------------------------------------------------------------------------------------F---ERSKS--------------------------H-------------------------IL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FV-V-----SLDDS--SVNV----------------EHYLKI---------------------------LNNKI----------SSAK-TNNFKVITCDG-----------------M----------------------------------GH-------------------------------------------------------------------1290
1291 -----------------------------------------------------------------------------------G-------F---------------------------------------------------------A--------------------C-----------------------------------------------------------MALEY----LAP-AM---L--K--------------------------------------------------L------T-D---VN-----------------NTYFE------------------------------K--------A----------------------------------------------Y-----------------------------Q--IL-------------------------------------------------QNHPLVQ-KD---------------------------------------------------------K----M-AM--L-G--LS-----------------FG-----------------------------S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-ITFSMT-------------------------------------A------------------------------------------YSR-V--IKPQCCVCI----------------------------------------------------SGSHVVPVDKCLF----------K--VI-------EDFTGLVDKVPVNEDNHLI-------HRDMLLPI--------------------------------------------------PSDPA------------------------------------------------LK------VD---------------------------------------------------------------------------------------------------------------V---GRIKC--------------------------P-------------------------LL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-N-----GTDDQ--NWPT----------------VESAED---------------------------IEMIM----------EKAGNRHLLTVLTYPD-----------------A----------------------------------GHLIEPPYTPHFRASNFILYDTKKKVVMLWGGQTKPHAYA-------QEDSWKKILAFLQEHL------1291
1292 ------GVRGTLFLPPGPGPYPGVL-------------------------------DLWGGGG---GLVEYRSALLASH----G-------F---------------------------------------------------------A--------------------S-----------------------------------------------------------MALEY----LSP-DE---L--R--------------------------------------------------T------A-D---VD-----------------VSYFE------------------------------N--------A----------------------------------------------Y-----------------------------Q--IL-------------------------------------------------QNHPKVQ-KN---------------------------------------------------------K----M-AM--L-G--LS-----------------FG-----------------------------S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------A-ITFSMA-------------------------------------A------------------------------------------YST-I--IKPQCCVCI----------------------------------------------------SGSHVVPVDKSLF----------E--VF-------EEIKKNMDKVHVNEDNHVI-------QRGMILPI--------------------------------------------------PSDPA------------------------------------------------QK------ID---------------------------------------------------------------------------------------------------------------V---GRIKC--------------------------P-------------------------VM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LV-N-----GGDDQ--NWAS----------------VESAQD---------------------------MEMMM----------EKAGNRHLLTVLTYPD-----------------A----------------------------------GH-------------------------------------------------------------------1292
1293 -----------------------------------------------------------------------------------------------------------------------------------------------------G--------------------V-----------------------------------------------------------TVLLYDPRSTGLSDG---TPRN----------------------------------------------------------------E-----------------IDPVK------------------------------QAAD--YSDA----------------------------------------------L-----------------------------T--FL-------------------------------------------------STQASVY-PS---------------------------------------------------------Q----L-FF--W-G--MS-----------------FS-----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V-VALCAA-------------------------------------T------------------------------------------TDK-R--IRGV--LAI----------------------------------------------------AP-----------------------LTD-----LTYKPEHRRAKVLQQCMQDRA-------SQSAGNEP--------------------------------------------------YYLPL--------LNEQGENPAGFGVGL--------------EREEYARIVAAGRKLAKGHVN---------------------------------------------------------------------------------------------------------------R---TTIQSYYHMAMWQPFGLWAGVA-------PTP-------------------------VM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FV-V-----PEMDT--VSP--------------------AER---------------------------QREYF----------DTKLGNAPRRLHLVEG-----------------A----------------------------------GHMDIVQGAHLEG--------------------------------------------------------1293
Active site residue: X
Putative: +
Experimental: #
