Alignment for family S30
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30
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1 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVKLNSTQ---------------------------------------------------------------FKSFQRKLFT----AARDNN--HIVDIIVK-------RKTSVRFVKYQSRTY-AQ---VDVHHLSGKLRKTDMDNNTFV----NDCLDVMAKITAGNQ-PHTTEEITF-----GWSGMVL------------RTDKLLGKRTKSS---LK--------SFVVRGKDGSR----LVDARTRTS--- 1
2 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------KCKVDQNK---------------------------------------------------------------IGVDQLVGLVCDIMKVKDNGEIHLID---K-------KVQKFDFKRKHGTIY-AR---AQVKHLQGRRQRRDFESNPAL----DIWVDILMRRTVGRR-THKTNSIEA-----GWSGFLL------------NASKLIGRQSTHR---GN--------TFVVRGKCADT----LFDARVRMT--- 2
3 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Y-LK---INTKHEEGFNKARDVVMDNFT----QRLLELMITRTSGNN-RHSVQNIKP-----GHSGFVL------------NRETLCGTQSRAY---GR--------VFIVRGNHEGK----LYDARIKLSQ-- 3
4 -QLQFGTLPPVTISVTDSTNVTAMETDLKPGKQNKPTDAQRKVN----DNKAFIQSMHSEYTKQCTTLDKWEEEYNKARSMRPNSYKLVQTRQQRKAMLKRSMEKTSKQLKEQTDILEKCVIGPWGPPM---------------------------------------NTFSIAAGP--LPSAMETE--K----KWPL-HQTRS----Q-----------RIKKS-QMRPVK--------LDQGGFKKLVRELTTLMMLKSATFELCD-K-------HTQKVSVCRRHKKIY-LK---VHTMHEKGFNRARDVKIENFA----QHILELMVARTSGNN-WHSVRDIKP-----GYSGFVI------------NRKTLHGAQSRAY---GE--------IFIIRGNHEGK----LYDARIKLSST- 4
5 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PL-HKTPS----M-----------K-KRT-VHRICK--------MNDQGVDMLTRSLVKIFKTKSANIEYIG-K-------KSIKVDFIRKERTKF-AR---IQVAHLLGKRAQRDLLTGMEE----NHFIDIL-SKYSGN-----KTTINPGVVCAGWSGIVV------------GNGILTQKRSRSP---SE--------AFVIRGEHEGK----LYDARIKVTR-- 5
6 ----------------------------------------------------------EEANREKAIFLDFENSLGRRPYGIAQNEKVIMTARGVSKIVPISTRAMKHKRARERRRLEQPITLKWEPKL---------------------------------------SEFSIGGGP--SAKTIEEE--ETHT-KWPL-HKTPS----T-----------K-KRT-VHKKCR--------MDYQGIEMLMRSLIKISKAKNANIEFTD-K-------KTIKVDFVRKERTKF-AR---IQVAHLLGKRGKRDLLSGKKE----NQFIDIL-SSYSGN-----MKAIKPGVVCAGWSGIVV------------RNEILTQKRSRSP---SQ--------AFVIRGEHEGK----LYDARIKVT--- 6
7 ------------------------------------------------------------------------------------------------------------RDERKKRLEHEEFLKGSPTVV---------------------------------------AHISIAGGA--LPSQNTGE--ETPVKRPQW-HSNNK----R-----------V-RKP-IPRSPT--------LNAEGLASLMRAMGKIGARNSTKIEIVD-K-------KKVSARFVTRDAGSY-LQ---VRVAHHDGLRRKRDLKLSAFA----DQCLQHLSSKTHGST-YHHATQLKA-----GDSGLVL------------SARRLFGWHSGSC---SQ--------IFIVRGNHEGK----LYEARRKVT--- 7
8 MASFMVGSITVNTASVLKESFAQKVLTTPPVLVAQPVQRSFDAA----RMCARKAIADYEEKVAKAFSALEARCAARVSRMGTIRVKVMRSGTLRAQPLPKREQARLRKAERKARLEHEEFLKGSPTVI---------------------------------------AHISIAGGA--QPSQDMVE--PMSTRKAPW-HSASK----R-----------A-RKA-TPRSPT--------LNETGLASLMRAIAKIGAKNSTKVEIVD-K-------RRVQARYIKRDAGSY-LQ---VRVAHHEGLRRRRDLKLSAFA----DQCLTQLVSTTHGTK-YHHVTQLKA-----GDSGIVL------------LARRLFGWHSGSC---SQ--------IFVVRGNHEGK----LYEARRKVTLTM 8
9 ------------------------------------------------------------------------------------------------------------RKRAQREESKL-FMNTPVACV---------------------------------------TSINCVSSETNEIEDIKPG---------------------R-----------K---CATSRKLVRKKPYSKIIGAAIVNNLIAAVSKIMKSDGKELQIVHKR-----GARIIKFTDKR-------AY---VRVKHLEGKRCQTDLATDEQT----ERIFGVICKSTVKGFWKNNAS-IQA-----GDSGLVI------------HKNNGLTNYSRTR---GD--------YLIVRGRHEGK----IYDARTKIT--- 9
10 -------------------------------------------------------------------------------------------------------------RKIQKSKRRIRTFQAPDNVI---------------------------------------SNIKVDFDDAGEICCEAAH---------------------V-----------K---TATSRSTKRAVSYKVLKGESIINHLIREISKICKAENKVLEICTER-----KRRVIHFKDHQ-------AF---VRLRHMEGIVKQRDCETNPEL----EALFERICETAV-GRWNTPSSKIVP-----GSSGLVV------------FKGRHLGKYSSSP---GN--------YFIVRGRHEDK----LYDARIRIG--- 10
11 -------MAFVMFGQFESALPLLHSGGASLTVAPNCVAPIKRDI----LKETRFQMMKEEAQRERAWAKLEEETRERYESFQRGTLKRLPYGFMTLKKPSIVKLHKERIERENQEREERIFDSLSPFPI---------------------------------------THINMCEQP--V-RVLENV--NNNI-TWSL-CRSFK----Q-----------KKPKR-VPSMPK--------LSVVHFEGFLTAIGKICKKKDMSLEIIDGR-------KTVKA----KTHLGS-CY---VRTKHMDGARKKIDLTLNERQ----EEMLFSLAKGLS-------RAPIPLSHLTYGDSGRII------------LNPICDTAYSR-Y---KR--------GLIVRGEHEGK----IYDARVKVTRSV 11
12 MASIMIGSFACPLMASAKVAT----------------------------GIACEESRANVGIRGAAMTVAHTVMAPIVQVTRPNVTQVNNYGRRLIKQAEDKVESAFKNFFDKPEMKESLFKKSHAKLVRGRKQGWRLSTPSLEVAQQRQAKIDELMQEEADFLARKYDPQDVIGGH--VLVRDQTKRGEQVSFKGPFWHRTYK----T-----------KHTRTNTLSSPR--------MDETSLLGLVRGVFKIAKAKNLAIEIIG-K-------KVIKARYEQIGRSRY-LR---FATKHHEGRRSQRDMPVDHST----SSIQNEAVAVSAFKQ-PL-ARGITY-----GDSGLAI------------DANQL-GKVGRTF---SG--------YTIIRGECEGK----IFDARSKVTK-- 12
13 ------------------------------------------------------------------------------------------------------------------------HTIPDPSLV---------------------------------------S----------LQSRQRTT------------HASDK------------------------------------MNGVNTSTLIHHLTRIVHDRQLDVHFVG-K-------RRLDGRCVRVDGKSY-LQ---LQTKHTSGLRRRVDCHIPKGL----ESVIHALAKGSGYKS-RVHVSKIKK-----GWSGFVL------------QPKNITGLIGKHR---HD--------FFVVRGSLEGK----LIDACSRVNSR- 13
14 ---------------------------------------------------------------------------------------------------------EVSVSKSIEETHVAEHKKPDPSLV---------------------------------------S----------LQSRQRTK------------HASKK------------------------------------MSGNSFPELIQHLTRIVHDRQLDVHFVG-K-------RRLDGRCVRNNGKSY-LQ---LQTKHTLGLKRKVDCHIPKGL----EHIIHAIAKGSGYKA-RTHISDIKK-----GWSGFVL------------QPKNIIGRIGKHM---HD--------FFVVRGSSRGK----LVDACARI---- 14
15 ----QFGSFTELETSEPVVSAPKPNCEEPARTIAKPEEPVEQETCGDGKRLLQAQMEVDKAEQDLAFAYLSASLKPRLEGRTTATIARRRDGCLVYKTKPSWSQRKGTKKILKVDTLACK-NPYIPAVV---------------------------------------DKISIAGGS--SASV--MH--EQQK-PKIL-HTTPS----R-----------K-VAT-HYKRTV--------MNQQTLTALINQVGTIILNAEKEFEVVGCR-------KQKVTGKGTRHNGVRLVK---LKTAHEEGHRRKVDIRIPNGL----RSIVTRISARGGWHK-TWTDSELSP-----GSSGYVL------------NSSKIIGEFGLRR---HS--------IFVVRGRVYGK----IIDSQSKVTHTL 15
16 MSTICFGSIECKLPYSPA-------------------------------SCGHVTEEREVLASVEPFMDLEAQLSARLLRQKHATVRVLKNGTCAYRYKTDAQIVRIQKKLERKERDEYHFQMAAPSIV---------------------------------------SKITIAGGD--PPSK--YE--PQTP-KRVI-HTTPR----V-----------R-KVK-KHSIIK--------LTESQMNHLIKQVKRIMSAKKGSVHLIN-K-------KSTHVQYKEILGTTR-AA---VRTAHMMGLRRRVDFRCDMWT----TERLKCLARTDKWSN-RVHTINIRK-----GDSGVIL------------NADSLKGHFGRSS---GG--------LFIVRGSHEGK----LYDARSKVTQ-- 16
17 --------------------------------------------------------------SVDPFTNLEAQLSARLLRQEHATVRVLKNGTCAYRYKTDAQIVRIQKRLERKERDEHHFQMAAPSVV---------------------------------------SKITIAGGS--PPSK--SE--PQTP-KGII-HTTPR----V-----------R-KVK-KHSMIK--------LTESQMNHLIKQVKQIMSAKRGSVLLIN-K-------KNTQVQYKEILGATR-AA---VRTAHMMGLRRRVDFRCDMWT----TECLKSLARTDKWSD-QVRTINVRK-----GDSGVIL------------NANKLRGHFGRSS---GG--------LFIVCGSHEGK----LYDARSKVTQGV 17
18 MSTICFGSFECKLPYSPA-------------------------------SCEHIVKEREVPASVDPFADLETQLSARLLKQKYATVRVLKNGTFTYRYKTDAQIMRIQKKLERKDREEYHFQMAAPSIV---------------------------------------SKITIAGGD--PPSK--SE--PQAP-RGII-HTTPR----M-----------R-KVK-TRPIIK--------LTEGQMNHLIKQIKQIMSEKRGSVHLIS-K-------KTTHVQYKKILGAYS-AA---VRTAHMMGLRRRVDFRCDMWT----VGLLQRLARTDKWSN-QVRTINIRR-----GDSGVIL------------NTKSLKGHFGRSS---GG--------LFIVRGSHEGK----LYDARSRVTQ-- 18
19 MSTICFGSFECKLPYSPA-------------------------------SCGHIVKEREVLASVDPFADLETQLSARLLKQEYATVRVLKNGTFTYRYKTDAQITRIQKKLERKDREEYHFQMAAPSIV---------------------------------------SKITIAGGE--PPSK--LE--SQVR-RGVI-HTTPR----M-----------R-TAK-TYHTPK--------LTEGQMNHLIKQVKQIMSTKGGSVQLIS-K-------KSTHVHYKEVLGSHR-AV---VCTAHMRGLRQRVDFRCDKWT----VVRLQHLARTDKWNN-QVRATDLRK-----GDSGVIL------------SNTNLKGSFGRSS---EG--------IFIVRGSHEGK----IYDARSKVTQ-- 19
20 -ST-----------------------------------------------------------TTDPFASLEMQLSARLXRQEFATIRTSKNGTCMYRYKTDVQIARIQKKRKEREREEYNFQMAASSVV---------------------------------------SKITIAGGE--PPSK--LE--PQVR-RGVI-HTTPR----M-----------R-TAK-TYHTAK--------LTEGQMNHLIKQVKQIMSTKGGSVQLIS-K-------KSTHVHYKEVLGSHR-AV---VCTAHMRGLRKRVDFRCDKWT----VVRLQHLARTDKWNN-QVRATDLRK-----GDSGVIL------------SNTNLKGNFGRSS---EG--------LFIXRGSHEGK----IYDARSK----- 20
21 --TMMFGSFPSNIPFVSHTVPVSESSKGLDEVTNSTLEARETVV----FTVKTLSTDTPMAKCTDPFDKLDEILAKRLEKQAFATITKRKDGTLFYKYRSNKQLDKIKSKIQKQKEEEEKFQQSPPTII---------------------------------------TRISIAGGP--APSQ--VM--EIGG-KRGI-HTVPS----M-----------K-TKR-AFKKQN--------MTDAQFTNFIKKIKSIMAQKHASVEIIT-K-------KSTKLDYVTRSHKTC-AR---VAVLHLKGIKRRVDFSCDSWT----SNIVKQLSKVGKWQD-QVHTTQLRK-----GDSGVVL------------NAKKLKGHQSRSW---NG--------MFIVRGVYEGK----LFDARTKVT--- 21
22 ---------------------------------------------------------------------LEEKLEAYFDKRKYATIKKLKNGTFVYKHKTDAQIKRIKAAEARKEQELFSFKTSPPTII---------------------------------------SSISIGGGL--QPSA--MP--MEAQTHKKI-HTTPS----A-----------R-KRC-VLKKVS--------LTDTQLLNLVKQVKNIGVDKNLTIEVIG-K-------RRNVIRYKDFRTNVG-AF---IEVRHELGKRARVDLRIPNSN----IPFVQILAKTNAWGM-KVKTLDLRR-----GDSGVIL------------NPKKLHGKQGRSA---HD--------MFIVRGNCEGQ----VFDARSRVT--- 22
23 ------------------------------------------------------------------FAALEERLAPYFARRMHASIKQQKNGTLVYKHKTPAAIKRIEGREARLVQEELNFKNAPPFII---------------------------------------TNISIAGGM--APSV--ME--EGVA-ARII-HTTPK----M-----------K-KPK-YHKREA--------LNNAQFMHLLKQIKNVALLGNLQIEVID-R-------TKNKIDFIGEH-KKR-AR---VHVKHLRGITHRRDCVFDKWT----TSVVRILAKTNTWGD-HILCTELKK-----GDSGVIL------------NPDRMHGKRGRCA---DG--------IFIVRGKCDNV----VLDARSRVT--- 23
24 QATIMFGSFECKLTQSVAPKAT---------------------------HMATLSHENPVKRVINPFTALEKSLQPYLEKRMFADVRKKSNGTFVLKHASAKKVQKLQKLEATRLKEISDFKMGSPSIV---------------------------------------SSISIAGGH--SASQ--MQ--DEPSMKRPL-NTTPS----R-----------K-RKI-SFKKVG--------MSGTQMMNFIRQLKNIMADKCGGVELVG-K-------RTTKLKYSRTRLGVK-CI---CELAHMKGSRKRVDLRLNGEH----TEFVRQFARVHSWGN-TVDSHMLQR-----GDSGVVL------------NSSVCRGKFGRNW---DN--------LFIVRGEYEGK----IFDARSKLT--- 24
25 ---IMFGTFECKLANPMGLAPA---------------------------VIASAEHKSSNKQAANPFAALESELQPYLDRRLYAGIKMQKNGTLTLKRATDRAVRKCKKLATARKQELEEFKLGSPSIV---------------------------------------SKISIAGGP--VVSQ--MQ--DDTIVAWPL-HKTPS----M-----------K-LKT-NHKKVA--------MTQTQLSSFIRQLKNIMIEKGGNIELAG-K-------TTTKLHYKQTHMGVR-CV---CELAHVQGKRRRVDVKVSAEH----ASFVLELAKVPSWGD-VIRSNSLRR-----GDSGVIL------------QSRVCNGSFGRSW---GG--------FFIVRGAYEGK----IFDARSKLT--- 25
26 ---IMFGSFMCTVPHAVQLPVK---------------------------PVVGTSHAELEVAVKDPFADLEVSLQPYFERRMFANVRKKQNGTIVYKRPTANKVSKLKKRALSLKKEHEEFMLAAPSIV---------------------------------------TTISVAGGP--SPSQ--LQ--EEVKQVKPL-HKTPS----M-----------K-RRV-SYRNPV--------MTDAQLNWLVKQLKNIMAKKEGSVELVG-R-------KTTRVHYRATHLGVR-AM---CELAHMRGIRKRVDVKIPTEH----VPFLKSLARVPTWGR-VVHNTDVRR-----GDSGMIL------------QSKLCRGHFGRSW---DD--------LFIVRGSFEGK----ILDARSKLTE-- 26
27 ---------------------------------------------------------------------LAKDLEPYLQRRMDATIRTKANGMRMYRHKTDKQLQRIYKMREQREAERMAFLKADASII---------------------------------------TTISIAGGS--VPSA--MQ--EFVVHKRPL-NKTAS----A-----------K-QRR-TFCPLK--------FRSGHFEKLLKDVKNIAVANDLAIEVIG-K-------RTNRVTYVRNNSQVV-AR---VELQHMNGKIRRVDCVMPPSN----ARIVSYLARTTTWGS-RINCDKLVA-----GDSGKVF------------QSSLCVGNIGRSF---NN--------LFIVRGRYEGK----LFDARSKIT--- 27
28 TSVIQFGSFVCNLPKSQPLCTTV--------------------------HCPKQSMSTNIVRPSDPFAELEKHLEPYLQKRMDATIRQTKGGTLVYKHMSEAKRARKLRKKQREEEEVRLFMNAAPYIV---------------------------------------SNITIGGGE--VPSK--ME--EVSI-KRPL-NKTPS----R-----------K-IKK-SLTPVT--------FRDGHMNKFLRELRDCATRNSMTVHLIG-K-------RKTELAFKRRASLNA-VY---ATLHHMRGVDRKRDIVLEEWM----NDYVLNLSKVSTWGS-LFHAESLKR-----GDSGLIL------------NARALRGKFGRCS---RG--------FFIVRGKSDGV----VLDARSKLSMAT 28
29 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPS----M-----------K-KKK-TLKSPR--------LTQEKIHELTQAVLKIACRKRMNIELVD-K-------KSTKGQYKKFQGANY-LF---LHLKHMEGLRESVDLRIHTTT----QNLVLQAAKVGAWKR-TVKTTMLSK-----GSSGLVL------------NPDKLLGPRGHAP---HG--------MLVVRGALRGV----LYDARMKLGR-- 29
30 ---NEISEVLIAAPTEMKKAPKAPLPK-HLYPWTSKTQTPGEVHHKMVRKWVQKTQQAAAEKEKLVWKKLDEQLAARNEARKDLKVKWRWGLYRLVRKTRKDNQRQRRQKRMEK--EQQSLMAMPPQIL---------------------------------------TSISIAGGP--AASLEMTPTLNGKI------FCTPS----M-----------K-KKR-ALKSPT--------LTQEKIHELMQAVLKIACKKEMNVELVG-K-------KPTRGQYKKFQGAKH-LF---LHLKHMKGLRETVDLRIHPTT----QDIVLQSAKVGAWEK-LIKTVTLSK-----GSSGLVV------------NPYKLLGPRGHAP---QG--------MFVVRGALKGV----LYDARMKLG--- 30
31 ---------PTKEDTDVGAQKSTSLPA-HLYPWAPRSKNSGATRHQMVRKWVKKTQEAEEVKQKAVWKKLDEQLAVRNEAKKDLKVKWRWGLYRLVKKTRKDNQRQRQKKRMEK--EQQLLLAMPPQIL---------------------------------------TGISIAGGP--VASLQETPTVSGKI------LSTPS----M-----------K-RKR-ILKSPT--------LSSDKIQELIQATLKIACKQGLQVEIIN-K-------KTVKGAYRQHGGTNH-LF---LHLKHMEGWRKPVDLHIHQED----IELVTMAARVGAWNK-KFHTSQLCR-----GTSGLVL------------NPDKLTGPRGHAP---KG--------LFVVRGALAGV----VYDARMRLG--- 31
32 TSAHMAGANGSILKKAEETSRAIM-------------------------HKPVIFGEDYITEADLPYTPLHLEVDAEMERMYYLGRRALTHG---------KRRKVSVNNKRNRRRKVAKTYVGRDSIV---------------------------------------EKIVVPHTERKVDTTAAVEDICNEATTQLVHNSMPK----R-----------KKQKN------F--------LPATSLSNVYAQTWSIVRKRHMQVEIIS-K-------KSVRARVKRFEGSVQ-LF---ASVRHMYGERKRVDLRIDNWQ----QETLLDLAKRFK-NE-RVDQSKLTF-----GSSGLVL------------RQ----GSYGPAHWYRHG--------MFIVRGRSDGM----LVDARAKV---- 32
33 -MATQVIMVGEFKILEVNCKPHAPVAAIHVPTQTPKTND-------------------------IKWADLEFTLAKSLQRQAHGVVKVDKHGTARIKRASKHHMSCLEQQMADEVAEKEAFMAAPTQLV---------------------------------------TSIIFAGTT--PPSMMETETIVKKI------HTVGKRAKVM-----------R-KRS-YITPPTDKSLRNHGVTPYSVQQLCRTLGNLSKRTGISLEVVG-K-----TSKATKLRFTKTSFGHM-AR---VQLKHHDGRMHRRDLVVDTSTTTIMQTLFLKTARTNA------NLDVLTH-----GSSGLVF------------WNYLVTGQRMRTR---DN--------FIIVRGRCNGI----LVDARAKLSES- 33
34 ------------------------------------------------------------ASVMSVWDKLKDELSSKFKSRADLVPVKTRSGLWKYGEPNGISKDWLEKKQP-TTFQFPEAQCDVT----------------------------------------------------------HISIAGGPKPSSEVVKDQPK----K-----------AQATS-KRMKTRRVAPKLVKMTERQFTMFLAQVSAIMKKKNMRFE-IATRR----RVKAVKCGI---KSNTF-LKTVHVTTKHEGGIRKSIDLHMNSTQ----QNIIKAIVGNINKGR-ILNDTNFQR-----GDSGMVL------------LQQQLHGKFGRSI---NE--------LFVVRGRHNGV----LLNSLSRVTE-- 34
35 ------------------------------------------------------------------------------------------------------------------------TKC--------------------------------------------------------------------------------------------------------------------ALNEIQMGMLMKQVSAIIRQNNLAVNVIGQKK----KRRALNGNVLQRKEGKY-LK---VITKHELGVRARKDVLCDEFQ----QECIRTISSSILKKR-VFHENVADK-----GYSGIVL------------PQQSVQGKIGRCI---NG--------LFIIRGRHEGI----LLNSLSKLTE-- 35
36 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GMNFEIIG-K-------RSVSGRILQEEENEY-VK---INTIHECGPRKQIDVCTNRGI----DAILRIWSNKIQKKR-VIPTCEMRP-----GFSGVVV------------PVANVKGWVGRTK---ND--------ILIVRGSNYNQ----IIDSRVRVTK-- 36
37 AATMIFGSFTHDL-----------------------------------LGKAMSTIHSAVTAEKDIFSSIKERL----ERKRHGKICRMKNGSIYIKAASSTKVEKINAAAKKLADDKAAFLKAQPTIV---------------------------------------DKIIVNEKIQVVEAEEVHK------------REDVQTVFFK-----------KTKKRAPKLRAT--------CSSSGLDNLYNAVANIAKASSLRVEVIH-K-------KRVCGEFKQTRFGRA-LF---IDVAHAKGHRRRIDCRMHRRE----QRTMHMFMRKTT-KT-EVRSKHLRK-----GDSGIVL------------LTQKIKGHLSGVR---DE--------FFIVRGTCDDS----LLEARARFSQ-- 37
38 MSTIVFGSFTCHLDAAIHQDNADRVAKA----WARPENRQISNVHLLCRRTAKSLINTYESATASAWKGLEEKLQPMFAKREFSKTITKRKGLRCFKASSEQVIERKLKQQYKEERERFQWINGPENVV---------------------------------------THIEPVTEG--APTWVPFP----DIPKRPL-SKTPS----M-----------K-RHI-IFDKVR--------MSETTLQLFMRKVANNAKANGQKVEIIG-T-------KHVVGNYIRKSQLTY-FR---THVRHLDGLKPRYDITLDEAT----KKIVQIFANTSGFKH-VHGKGEITP-----GMSGFVI------------NPRNISDPMQIHD---TD--------LFIVRGKHNSI----LVDARCPVSKEH 38
39 MSTIVFGSFTCHLDAAIHQDNADRLAKA----WTRPENRQVSNVHLLCRRAAKSLINTYESATASAWKGLEEKLQPMFAKREFSKTVTKRKGLRCFKESSEKFIEKKLRKQYQEERERFQFVNGPDAIV---------------------------------------NQISVDKCE--ASVWVPFP----HIIEKPS-FATPS----M-----------K-KKV-VFTKVR--------MSEASLQLFMRRVAANAKANGQKVEIIG-R-------KRVVGNYTTKSRLTY-FR---THVRHLDGSKPRYDLVLDEAT----KKILQLFANTSRFHH-VHKKGEVTP-----GMSGFVV------------NPINLSDPMQVYD---TD--------LFIVRGKHNSI----LVDSRCKVSKKQ 39
40 --------------------------------------------------ASKAMLDDYSKTTAAAFATLRNVEAKAKARHEESRICSVRKGVFGYKPYTKNFLRKRSLQQKQREDEEKWFQSQPDSIV---------------------------------------GRIISYEQPQLIE------------------EDTPRVVWPR-----------ALKKPRIASTPKKL------LWNECGDELMKAVQPTSYR---TLEVIGNK-----RRQTHRISLKRVNWKSV-FK---VETRHETGLKVGLDPPTSAFQ----NHILNRLLRITPRLS-IREIENLTK-----GSSGYLI----------------------------DDPDDYAARVPFVVRGRYNSI----LLPS-------- 40
41 -------------------------------------------------------VVENPNKDTVVLNDFFKNFQFNEERR--SKIYTDKHGNVRYGKRPMKKRKRGKK-----------VELVSDKII---------------------------------------TKIETPEEVQPVYSFEDLP---------------------------------SIKKAYSKKKPREIIKT---RTEYSVRSLVKEIGKTCSFT--EIMIIDKK-----------IRKIKKRGSRYF-----VDVRHLNGCNPEVDLDHSSFS----DEILDWLMASLAVKS--TKLSEIVP-----GTSGLIT------------VGRNEFGK------------------FTIIRGWLDR-----IVDARENLTKS- 41
42 VNCFMVGTIKCKINENSIVAKGVMAAIPRQLTQDEVFMRKARLQ----AAVAKSTIEREEKERQFAFSKLEEKLRARREKLKDGIVIKTRKGLEWREATPNQQRGKLQS-----------------------------------------------------------TSFDASGGKTLTPHTIYCKTKSSKFSNGGVKCATSK----------------KMRTVRKPQSLK--------MKTESIDVLIEQVMTIAGKHAKQVTLID-K-------QKTNRVWIRRVNGVRLLQ---VETKHHKGIISQKDASLNNLT----KRVARHFARKTAYIH-P--SDSITH-----GHSGVVF------------LRANISGSKSYSI---DD--------LFVVRGKRNGK----LMESRNKVAWR- 42
43 VAHFMVGTITCNINVNPIVTKSIMAPIPKQLTQEEIDKRKAALQ----LAVAKATIAREEKIKQAALSKFDKNSQVKHTGLKDNTNVKTESDGGWIQATPKHCVKVKQN-----------------------------------------------------------SSITTAEKTVLIPHIAHCKTAPNKFSLGGKKCATSK----------------KMRIVWKPRNIK--------MKAESIDALIDQVVTCAGKHAKQVFLID-K-------QKANKVWVKRVNDIRLLQ---VETKHHRGKISQRDVLLNDLT----KRVARYFASKTTHVH-P--SSSITH-----GHSGVVF------------LRENIDGNKSYSS---DD--------LFVVRGKRNGK----LMEGRNKVAWHK 43
44 ----------------------------------------------------------------LQFGSLNTGL-------------VMTGNNWIVKPYDQETEKRAIAREWHAYYLNAGRELTTPTKAFEAFD----------------------------------------------AKMREKESVELPVVQHDADETTPECTLTD----DKGWFVQKVSRANKHKKP-KHTG----D----ASNLIRAVLNVSKKTKIPIEIIG-K-------RRTTLRFKNTHGKKL-LH---AVTQHEMKRIRRTDLQCDAFA----NATLNLVKQTNHVTP-IASIREIKP-----GHSGAIL---------------------KDAY---ND--------IFIVRGISNNM----LVDARTHV---- 44
45 ---------------------------------------------------------------MMNFGSLNVGL-------------KQVDGTWVPRVFEEKEMARLLAEKQHARVMRATQEMMKAPNPFAEFDEMH-------------------------------QRGNPFAGRVRKCETREPKSAQKPIVTVD---TVPVAIYTDVIWPENG----KVHALSRRRAPRKHAR----RSKILACDLLTQVLNISRRAGKSVEVIG-K-------RRCCLKPRRRDGKSC-FG---VITKHHKGVLSSRDMVKDLFV----DSIIEHIAYTGH-TP-LIDAADIKP-----GDSGLIY------------------REKKDGY---V---------TRVVRGRHDGD----IIDARDYVRAGI 45
46 --VKEAVHLALEVGNEIAE--RKPELKLTPYWSASLELHKRIRKHNEHSKIEAIRMRKEKEINKNIFAALEVKLNLR-ARRQGQVIVCDKRGTFKWKKRQQCKKSKVLSQVSDTVVTKIHSDFACKTLN---------------------------------------LNTAIPGIK----------------------RATSK----R-----------MWKRQKQPKI----------IGSNKVNHVMKNLCDIIIDRNIPIELIT-K-----R-----CRRRIFRKDGK-NY---VQLRHMTGANKPKDVSSSPEM----EKLFTRLCKFLIRKQ-PVKAARLTH-----GSSGLIF------------KP-KFADRVGRYF---GD--------YFITRGRYEGK----LFDGRSKLARSI 46
47 --IEEAAYLALEVGNEIAE--KKPELKLTPYWSASLELHKRVRKHKEHAKIEAIRVRKEKERDQRIFAALEAKLNLG-TRRKGQIVVCDKRGTLKWEKCQQRKKSKVVAQVSDSVVTKIHGNFECETRD---------------------------------------LDVAIPGIK----------------------CATSK----K-----------MWKKQKSSKL----------RGSNKINYVMKNLCEIIVDRNVPVELIT-K-----R-----CRRSIFRKDGK-NY---VQLRHMSGGNAPRDVSSSPEM----EKLFTRFCKFLIRRQ-SVKAARLTH-----GSSGLIF------------RP-KFADRIGRYF---GE--------YFITRGRYAGK----LFDGRSKLARSV 47
48 --VKEAVHLALEVGNEIAE--QKPELKLTPYWSASLELHKRVRKHKEHAKIAATQVLKEKEKDRKIFSALESKLNLK-ARRKNQTVVCDRRGTLKWKTRQGHKKSKLMQQVSDSVVTQIHCDLDYKPQY---------------------------------------SEFHFSGIK----------------------RATSK----K-----------VCKPRKQMRI----------VGNNKINYVMKNLSGIITERSIPVELIT-K-----R-----CKRRILQKKGK-SY---VQLRHMEGIRAQRDASSSLEM----EQLFTQFCKFLVGHK-SLKSSNLTY-----GSSGLIF------------KP-KFADNVGRYF---GD--------YFVVRGRLGGK----RFDGRSKLARS- 48
49 ---KQAVVVALEVGNQIAEVCKINELRSN---NDNLNLMKVICKHRMHTLEMRKEVRARVEKDKAIFKDLEMKLNLR-NRRKNQIIKKDSRGTLRWRRRETLSKKRV--QIPENIITEIANDHQESRIE---------------------------------------ECVLVPGIK----------------------CATSK----K-----------MPKKRLLQQF----------LKGSVDDLILQTIQLCKQERKV-IEVIG-K-----RGVKINC-------GAT-TI---VELKHMKGKMSKRDMPCDDFV----DSFFSKFIKKLSRAR-TEWS--ICR-----GDSGSIV------------Q-------IGSKF---G-----------IVRGRLDGY----LVDARDILS--- 49
50 ---------------------------------------------------------------------DGF-----------------------------------------------------DSVV---------------------------------------THIVI-PSTTRVENDKSLQ---------------------V-----------KHPAVVYRKRKTPPRQNYVTLDERGLSDLFTELSQYILLDRQVMQILQAG-----KRKPITISRCNVGP-YTTLH---VTTKHELGKMAPIDLSLDEDS----ESILQSFANTLPTTL-DIREEDFRP-----GTSGAIIRRDCLDNVAHKVP-----------D---SD--------YFIVRGRFAGS----LLDAR------- 50
51 --------------MAAQVTFSCFRNGSGVAADACRAQTMKFAFGSFVPGKIDWNTISSAMIEEYEAKQESFELACEKFQRGRTDTRVVRRKEFFQYAPKTRYQLKMARKKERKEEQKRRSLASSDTVV---------------------------------------TRIVFPPEAAKAEVSIEL----------------------I-----------RFPPVVVRKVRKQPRPNITRVSTDGFSCLIKELVG-ICDNKQVPLEIIAN-----KREKICARIRRFTPSHRCAQ---VKTLHHQGMYQSVDFKCPATL----ENLFGLIAQHAWKGR-SIEESKLTY-----GSSGFCI------------PHGKLYGRVLSGD---FD--------FFVVRGRYGSL----LVDACAHFPSAI 51
52 MNTITIGTI------------------KVNIKQNADTPM----------GEGTKKIFPFSSITKDPFADLQAKCADRISRMGELCFLTKGRYTTMIPKPEHVKSQEKLRREEELNFLNSEHILSS------------------------------------------------------LNTTDHSEPNSTWNRGVQVTFRSPFYKRTL-----------KVPVKKAKRKQI--------RGLQSAYHIARELLCIVKKRDLVLEVADIK-------KRANFATFKKYGKEYGMH---IALNHMVRKRRRVDVNL--------NKLMHEVATINAIPFEKLNTLTVKE-----GHSGLVL------------QTETVPNVCNNK----SR--------ITIVRGTVMESGIPVLVDARKELT--- 52
53 MTTINIGTI------------------PIIIKQNADALM----------GEGTKKISPSVNISTNPFADLEMKCAKRLERMGELCFSRKGRYTTMVPKPEHIKIREKQQREEELNFQSSEHILSS------------------------------------------------------LSTDSTLKQYSTRSNGMQVSFKTQHYRRTI-----------KKPRTQVKKTEL--------KGRYKIQHVTRELLKIIKKKDLVLEVADRK-------NRANFATFKKYGKEYGMH---IVLNHMVRKRRRVDVTL--------NKLMTKIATYCAIPFECLETLTLRE-----GHSGLVL------------QTETVPNIHYNK----SQ--------ITIVRGIVKEGQVPVLIDARTKL---- 53
54 MAQIMIGSIMVPLNKESSVSESNINISSIIPKTKTSTHI----------EAGLKNMSFNLQPTTDPFKAITLACKERVAKFGDMVFKTRRGITTMVPKPARLVEEEKRAAEALKRFMEVEWTLEE------------------------------------------------------IDPDAEYQVPDLRQRGSQVSFKSPYHKRTP-----------KTAEKLKVIKPV--------QGSKKIQHVTNALLKIVKNNNLILEVADRN-------KKANHATFSKYGSTYGMH---IIVNHMVRKRRSVDVRL--------NGLMASIAKQEAIGFEKLNVSTLRE-----GHSGLVL------------QTKTVPNCHFNN----DD--------ITIVRGVIKSHGVPCLVDARQNLNHQ- 54
55 ----------------------------------------------------------MAGTWQHVTYKWQPNLDNPRDVKRSMELFAAKRQVYDEKRALEHNSRLLRRA----------QMVDVEPII---------------------------------------TVQPKKCTQTWKEVVDRN-----PTNHFVYTRFTEV----K-----------KQQPV--------------KPVATSVNALVRKTLEIRKKFPVNVEFVGKK-----RKNTTTVSLKKVFNKTF-LH---CGTRHENNQFKRIDTNITRDW----VPVLLSVAKCYATLS-TNMMHNVHK-----GHSGLTF------------IQN-------------DE--------LFIIRGRLKGE----LCNSL------- 55
56 ----------------------------------------------------------MAGSWTHVTYKWQPDVNNARDVKRVMEMFAAKHQHYTEEQRLAHNSKLLRKA----------CVTSAEFIK---------------------------------------PAQKPKCHQTWVEKCDHN-----PTEHFVYQRSTPE----K-----------KVLST--------------KPKTTSVTKLIRDVLEISKGSGIKIELIGKR-----VKRKTQLSIRQHNGKDF-LH---CKTRHENGLFKRKDIDINVKW----LPTIEAIAKCYSTVN-AEELQSLNR-----GSSGLTF------------MQN-------------DE--------LFIVRGRMHGE----IVNSLHE----- 56
57 ----------------------------------------------------------MDGSWATVASRKRPNLDNPYVVRKVMERYAAKHQEYDAEKALAKNLRILKRTHPGTNFTLPTTQVPVEQPR---------------------------------------EEPKLKRVQIWVKVADHNVKVDTPITKRVVAKEKPK----P------------------------------LIVKYDVASLTSQVIKMKQNTNCEVVIIGRKQNHITRLNAV-------TRNKR-LH-LHCRTLHEEGKFKRRDVQIPAQW----LPTLTAICRKFDTMP-RHEFAKLRK-----GDSGLTC------------FYN-------------NE--------LFIIRGRCENK----LVNSL------- 57
58 ----------------------------------------------------------MAGEWNTVVGKRNQRKTEEQRIFDAQKRFYETHQVYDAQRALLHNSRILKRN-----FELTNAIEKPKNDP---------------------------------------KPIKKVFKQVWVAKVKEILNEPKPIDIKPVQARD-------------------------------------EVVKVDIGKFARVLLDQCKAYKVPVEIVGRK-----RKVVSRIQPYLKHGKTF-LK---LETNHEQGRITRRDLSMPDPV----KKLVLKIADKYEEPT-DEDLETFSK-----GSSGITF------------KSET------------GM--------LFVIRGRVNGV----LVNALDQYEEDV 58
Active site residue: X
Putative: +
Experimental: #
