Alignment for family M20B

            2          3          4                5                      6              7         8         9          10         11        12        13        14        15                  16            17         18        19           20        21        22        23        24         25        26        27        28        29        30        31         32        33         34        35        36        37        38        39        40        
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   1 LELAHIE-------SPSRREGAIAR-YLQEKFEALGAQCLFDDSAPRTGS------------E-VGNLVVKLSPSS--------RARVFLAAHMDTV-----------------------------------EPTDSPKIIFTNGVFKSDGRTICGADDKSAIAIFLELAHVIKE----------NKLS--FPVE---FVFTTCEEIGLLGAKHLDYSLLSAPF--GYALDS-VDPLELINKAPEAIRFTIKVLGKAAHAGINPEAGINAIKIASEAIAGITLGRIDEETTANIGTIKGGKATNIVPAEVVVEGEVRSHNRETLKAQWQHIISSFEEAVKVYPRQEKDLPKIHYDKVKDYPLMYVSEKHPVIKTALKAANNLGQKLRISTTGGGSDANIFNDKGFPCVILGTGMKKVHTTEECLPFDEFLLAARLSLEIL-------   1
   2 LQVIQIN-------ALSANEKPLAD-FINSFLTNLGYKVEFDDSAKFTQS------------N-TGNLICKI--GS--------GGDFVMTAHMDTA-----------------------------------RPTENVKPMIKEDRITSSGDTVLGVDNREGVAVLLYSLERIAL----------EKI----PVKDFTVAFTTCEETTLFGSKYLG---LNGNIKKGFVFDSGYRPGSFIYSACGAIGFNLKIFGRASHSGIAPEKGINSLLIAANAITKLPLGRIDEETTMNIGTLKSGSAVNVIPELTEVVGEVRSFNLDKAENYFRQLVKTFEE------EAEKLNAKIEYDYFWDFKPYTIKENSDVYKEILRAITKVGLVPSPKISLGGSDANSLNAKGIESVNIGIGAQNPHSNDEFVYIEDLIKSAEIALELV-------   2
   3 MELVQVD-------SETKFEAEICK-VLTKKFTDLGVEVFEDDTMAVTGH------------G-AGNLICTLPATK------DGVDTIYFTSHMDTV--VPGNGIKPSI--KDGY-------------------------------IVSDGTTILGADDKAGLASMFEAIRVLKE----------KNIP-HGKIE---FIITVGEESGLVGAKALDHERITAKY--GYALDSDGKVGEIVVAAPTQAKVNAIIRGKTAHAGVAPEKGVSAITIAAKAIAKMPLGRIDSETTANIGRFEGGTQTNIVCDHVQIFAEARSLINEKMEAQVAKMKEAFETTAKEMGGHADVEVNVM-YPGFKFADGDH-----VVEVAKRAAEKIGRTPSLHQSGGGSDANVIAGHGIPTVNLAVGYEEIHTTNEKIPVEELAKTAELVVAIIEEVAK--   3
   4 LELVQID-------SETKHEAEICK-VLKQKFSDLGVDVKEDDTMDITGH------------G-AGNLICTLKGTK------Q-TDTIYFTSHMDTV--VPGNGVKPVV--ENGY-------------------------------VKTDGTTILGADDKAGLAAMFEAIKVLKE----------ENIE-HGTIE---FIITVGEESGLIGAKALDRSMITASY--GYALDSDGKVGNIIVAAPTQ--------------------------------------------------------------------------------------------AKDMGGRAEVEIEVM-YPGFKYQDGDQ-----VVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTVNLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAGK--   4
   5 LINTFIDFVKIS--SLSLREKEFSS-FLKNRLENLGLKVIEDNAGKTLGG------------N-SGNLYAYLDGDG---------EPILISAHMDTV--SPGENINPQI--AGDY-------------------------------ILSDGNTILGADDKAAISAIVEAIQTIKE---------KKERT--KKIE---FLFTIGEEIGLVGAKNIDPSLIKSKE--GYVLDGEGDVGTLILRA-------------------------------------------------------------------------------------------------------PTSYDLRKETLYRGFNIDEREK--VVRRIVDVLNQMEKKINLTYTMGGSDANILNSYGIKTVNVGIGMENAHSKEERIKIENLYDTAVLIYNLIR------   5
   6 LINTFMDLVKIS--SLSLKEGDFSS-FLKSKLEDLGLRVVEDNAGKILGG------------N-SGNLYAYLEGDG---------DPILISAHMDTV--SPGENISPKI--ANGY-------------------------------IVSDGNTILGADDKAAISAIIEALQTIRE---------RSENT--RRVE---FLFTIGEEIGLVGAKNVDRSLIKSQE--GYVFDGEGEVGTLILRA-------------------------------------------------------------------------------------------------------PTKYDLRKENLYKGFSIDENEE--VVRRIVRVLNNMGKKVELTYTMGGSDANILNSYGIRTINVGIGMENAHSKEERISIDNLYDTAVLIYNLIR------   6
   7 --------ELMAI-PGKSGEEALIAAEIKSRLLKAGLS-------ETMIQFDSAHKKSPIGGQ-TGNMIVKLPGTM-------RGPRRLLMAHMDTVPLCEGA--KPVK--------------------------------KGDLIHSKSELTALGADDRSGCSVILNALLTILE----------HNLP-HPPLS---FCWMVQEEIGLVGVRLLTTSKLGKPR-MCFNWDG----------------------------------------------------------------------------------------------------KLSDMVCNSEGKQGSVSF----ESYLKYDSFRLPEQEPAVQTARLAIEKQGGQPELTIANGGLDANWMTAHGFPTVTLGCGQQDIHTTSETLMIDEYLKACQIGLLLATAT----   7
   8 TIDTQSDPESPSS-PSTEKQKDLGR-VLVTELKAMGVA-------DAHLD------------D-YGYVYATIPANT-D----KKVPVICFCSHMDTSPDVTGKDVKPQV--VKNYRGGDITLPGDTSQVIRFAEHPALKNQIGNDIITTDGTTLLGADNKAGVAEIMDAAHFFIY---------NPDAK-HGTLK---ILFTPDEEIG-RGVDNVDIKKLGADF--GYTMDG-ETAGSVEDETFSADGATITINGVSAHPGYAKGKMEHAIKIAAAIVERLPKEGCSPETTSGKQGFLHPIGIDGALEQATLSFIVRDFTDEGLKEKEVLLENIVKDVMKDYPRS-TYKFEVK-EQYRNMKQVIDRHPH-ILEYAIEAIRRAGLRPMRTAIRGGTDGSRLSFMGLPCPNIFAGEHAFHSRLEWVSRQDMEKAVQTIVHLAMIWEEK-   8
   9 --DTQSDEESASF-PSTEKQKILSK-DLAEELKQMGLK-------DAHMD------------E-WGYVMATLPSNT-S----KDVPPIAFIAHVDTSPAVSGANVNPVI--RKNHQGGDIVLE-NGGWVIKESENPDLKNMIGFDIITTDGTTLLGADNKAGVAEIMDAINYLIT---------HPEIK-HGDIK---VCFTPDEEVG-RGTEKIDLKKLGAKY--AYTVDG-SSRGEIETETFSADAVVIKFYGKNIHPGYAKGVMINSIKIAASFIDSLPKDRLSPETTEGREGYVHCTSINGNEELTTLKFIIRDFETPKLKEYEDLLKKLAEEAVAKFPGS-RMEFQVI-EQYRNMKEVLDKHPQ-VTDYAVEAMNRIGIKPIMHPIRGGTDGSRLCFMGLPTPNIFAGEHSFHSQTEWVAVQDMYEAVKLIVEIAKVWEEK-   9
  10 RIDTQSDETSPTF-PSTKKQLVLSR-MLFDECEQLGLE-------DVTIN------------E-YGIVMATIPSTV-E----ADVPAIGWVAHVDTSPEFSGTDVKPIV--HENYNGEDLVLPGDPSRVLRVSEEPRLKQMQGKTVITTDGTTLLGADDKSGVAVMMSAAAKLMG---------DSSIK-HGPIR---LCFTCDEEIG-RGIEKLDLNAFGVCC--AYTLDS-DGSGRID-----------------------------------------------------------------------------------------------------------ITINIH-KQYRNMRDGLPKEPR-ALEKAIEATRAAGLEPNLNVIRGGTDGSLLTEKGLPTPNLSSGQHNPHSPLEWTTVEEMQQAVDVLIQLAILWGKER  10
  11 -----SDPESETT-PSTPQQWDIAK-YIFQELQNLGLS-------DVSLD------------D-NGYIMAYVPSNI-T----ENEPTVGFIAHYDTSPDFNGKDVNPQI--WEDYSGADLLLNKETGFTLSSAKFPSLKKYVGKTLITTDGTSLLGADDKAGVAEIVTAAEYLLA---------HPEIK-HGRIA---IGFTPDEEIG-RGAHKFDVKKFGAEY--AYTMDG-SEVGELEYENFNAAGAVVKINGLSVHPGYAFGQMKNAGLLAAEFALMLPANE-TPATTKGFEGFYHLTDFKGDVSEAKLQYIIRDHHADKFEARKQFIKDKVAAFNSKYGEN-TAEIEIK-EQYRNMKQQFEGKMH-IIDIAEQAMKDANIEPKIKAIRGGTDGAQLSYMGLPCPNIFAGGENFHGPYEYVALESMEKAVKVIVNIAK------  11
  12 SFDTQSDESTGLT-PSTPKQMVFAE-YLKTELESLGLE-------DITLD------------E-HGYLFATLPANI-D----KKVPTIGFIAHMDTSPDMTGKDVTPRI--VKGYDGTDIVLCAEENIILSPAQFPELLDHKGEDLIVTNGKTLLGADDKAGIAEIVSAIVYLKE---------HPEIK-HGKIR---IGFNPDEEIG-EGAHKFDVGKFGCEW--AYTMDG-GEVGELE-----------------------------------------------------------------------------------------------------------ATLELR-DQYYNMREKIEPVMH-IIDTAFAAMEAVGVKPNVKPIRGGTDGAQLSFKGLPCPNIFAGGLNFHGRYEFVPIQNMEKAMNVIVKIAELVASK-  12
  13 --NTRSDEASETI-PSTPSQMEFAK-MLKKELEELGLS-------NVFIN------------K-ACFVNATLPSNI-D----KKVPTVGFIAHMDTA-DFNAEGINPQI--IDNYDGKDIILNKEQNIVLKVDEFPNLKNYISKTLITTDGTTLLGADDKSGIVEIIEAVKYLKE---------HPEIK-HGDIK---MAFGPDEEIG-RGADYFDVKEFAADY--AYTMDG-GPIGELEYESFNAAQATFKIKGVSVHPGTAKGKMINAGLIASEIIEMFPKDE-VPEKTEGYEGFYYLVETHTSCEDGEVVYILRDHDKAKFLAKKEFVKELVKKVNEKYGKE-LVKLELK-DEYYNMGEIIKDHMY-VVDIAKQAMENLGIKPLIKAIRGGTDGSKISFMGLPTPNIFAGGENFHGKYEFVALESMEKATDVIVEIVKLNAER-  13
  14 --NTRSDDASETI-PSTPSQMEFAK-MLKKELEELGLS-------NIFIN------------K-ACFVNATLPSNM-D----KKVQTVGFIAHMDTA-DFNAEGINPQI--VENYDGKDIVLNKEQNIVLKVEEFPNLKNYVSKTLITTDGTTLLGADDKSGIVEIIEAVKYLKE---------HPEIK-HGDVK---IAFGPDEEIG-RGADYFDVKEFAADY--AYTMDG-GPVGELEYESFNAAQAKFKIKGVSVHPGTAKGKMINASLIASEIIEMFPKDE-VPEKTEGYEGFYFLDEMKSNCEEGEVVYIIRDHDKAKFLAKKEFVKELVEKVNKKHGRE-VVKLELK-DEYYNMGEIIKDHMY-VVDIAKQAMENLGIKPLIKAIRGGTDGSKISFMGLPTPNIFAGGENFHGKYEFVALESMEKATDVIVEIVKLNAER-  14
  15 -FETRSDENSETI-PSTPSQTEFAK-MLKKELEEIGLE-------NIFIN------------D-ACFVNGTLPGNI-D----KKVPVIGFIAHMDTA-DFNAVNVNPQI--IENYDGKDIVLNKELGITMSVEEFPDLKKYVSQTVITTDGTTLLGSDDKSGIVEIIEAMKYFIA---------HPEIK-HGTVK---VAFGPDEEIG-RGADNFNVEEFGADF--AYTMDG-GPVGELEYESFNAAQVIYKIKGKSVHPGTAKGKMKNASLIAVDLATMFPADE-VPEKTEGYEGFYLLDGMTSNCEDARVEYILRDHDRKKFEQKKEFAKNIAEKLNEKYGKN-TVEVFMK-DQYYNMGDIIKDHMY-VVDIAREAMENLGIKPIIKPIRGGTDGSKISFMGLPTPNIFAGGENFHGKYEFVTLESMEKATDTIIEIIKLNAK--  15
  16 ---TQSNENNDTC-PSTPGQLTLAN-MLVEELKSIGME-------EAAID------------E-NGYVMATLPSNT-E----KNVPTIGFLAHVDTATDFTGKHVNPQI--VEDYDGKDIVLNEELQVILSPDQFPELPGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIK---------HPEIK-HGTIR---VAFTPDEEIG-RGPHKFDVKRFNAAF--AYTVDG-GPLGELEYESFNAAAAKITVKGNNVHPGTAKGKMINSAKIAMELNRMLPEEE-APESTEGYEGFYHLLSIQGDVEETKLHYIIRDFDKEGFNNRKAEMERIVSDLRNQYGKD-RIILDMK-DQYYNMREKIEPVKE-IVDTARQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISAENMVKAVNVIVEIVKL-----  16
  17 -VDTQSDESVDTC-PSTPGQLTLGN-MLVDELKSIGMQ-------DAAID------------E-NGYVMATLPSNT-E----KDVPTIGFLAHVDTATDFTGKNVNPQI--IESYDGKDIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIK---------HPEIK-HGTIR---VAFTPDEEIG-RGPHKFDVKRFNASF--AYTVDG-GPLGELEYESFNAAAAKITIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADE-APEYTEGYEGFYHLLSIQGDVEETKLHYIIRDFDKENFQNRKETMKRVVEELQNEYGQD-RILLDMN-DQYYNMREKIEPVIE-IVNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNMVKAVNVIVEIAK------  17
  18 ---TQSNEESHTV-PSTPGQIEFGK-LLVEELKEIGLT-------EVTMD------------E-NGYVMATLPANT-E----KDVPVIGFLAHLDTATDFTGKNVKPQI--HEDFDGKAITLNQELNVVLTPEQFPELPSYKGHTLITTDGTTLLGADDKAGLTEIMTAMNYLLH---------NPQIK-HGKIR---VAFTPDEEIG-RGPSHFDVKAFGASF--AYTMDG-GPLGGLEYESFNAASAKLTFKGNNTHPGTAKNKMLNASKLAMEFHAKLPVEE-APEYTEGYEGFYHLISINGDVEQSKVHYIIRDFDRDNFETRKNTITNITKQMKEKYGEE-NIILEMN-DQYYNMLEKIEPVRE-IVDIAYEAMKTLDIEPNIQPIRGGTDGSQLSYMGLPTPNIFTGGENYHGKFEYVSVDNMEKAVQVIIEIARL-----  18
  19 -IDTQSNEESHTV-PSTPGQIEFGK-LLVEELKQIGLT-------EVTMD------------E-NGYVMATLPANT-D----KDVPVIGFLAHLDTATDFTGKNVKPQI--HENFDGKAITLNQELNVILTPEQFPELPSYKGHTLITTDGTTLLGADDKAGLTEIMTAMNYLLH---------NPQIK-HGKIR---VAFTPDEEIG-RGPSHFDVNAFGASF--AYTMDG-GPLGGLEYESFNAASAKLTFKGNNTHPGTAKNKMISASKLAMEFHAQLPAEE-APEYTEGYEGFYHLISVNGDVEQSKSHYIIRDFERENFENRKDKIAHITKQMQEKYGEE-NIILEMN-DQYYNMLEKIEPVRE-IVDIAYEAMKKLDIEPNIQPIRGGTDGSQLSYMGLPTPNIFTGGENYHGKFEYVSVDNMEKAVQVIVEIVQLFEEQ-  19
  20 KIDTQSNEESHTV-PSTPGQIEFGK-QLVEELKQIGLI-------EVTMD------------E-NGYVMATLPANT-D----KDVPVIGFLAHLDTATDFTGKNVKPQI--HENFDGKAITLNEELNVVLTPEQFPELPSYKGHTLITTDGTTLLGADDKAGLTEIMTAMNYLIH---------NPQIK-HGKIR---VAFTPDEEIG-RGPSHFDVKAFGASF--AYTMDG-GPLGGLEYESFNAASAKLTFKGNNTHPGTAKNKMLNASKIAMEFHSQLPAEE-APEYTEGYEGFYHLLSLNGDVEQSKAYYIIRDFDRGNFEARKNKIKQIVEKMQEKYGEE-NIILEMK-DQYYNMLEKIEPVKE-IVDIAYDAMKNLNIEPNIQPIRGGTDGSQLSYMGLPTPNIFTGGENYHGKFEYVSVDNMEKATHVIIEIARLFEERA  20
  21 KIDTQSNEESHTV-PTTPGQIEFGK-LLVEELKEIGLT-------EVTMD------------D-NGYVMATLPANT-D----KDVPVIGFLAHLDTATDFTGKNVKPQI--HENFDGNAITLNEELNVVLTPEQFPELPSYKGHTIITTDGTTLLGADDKAGLTEIMVAMNHLIH---------NPQIK-HGKIR---VAFTPDEEIG-RGPAHFDVEAFGASF--AYTMDG-GPLGGLEYESFNAAGAKLTFNGTNTHPGTAKNKMRNATKLAMEFNGYLPVED-APEYTEGYEGFYHLLSLNGDVEQSKAYYIIRDFDRENFEARKNNVKNIVKTMQEKYGED-AVVLEMN-DQYYNMLEKIEPVRE-IVDIAYEAMKSLDIEPNIHPIRGGTDGSQLSYMGLPTPNIFTGGENYHGKFEYVSVDTMEKAVQVIVEIA-------  21
  22 -IDTQSNEESHTV-PTTPGQIEFGK-LLVEELKEIGLT-------EVTMD------------D-NGYVMATLPANT-D----KDVPVIGFLAHLDTATDFTGKNVKPQI--HENFDGNAITLNEELNVVLTPEQFPELPSYKGHTIITTDGTTLLGADDKAGLTEIMVAMNHLIH---------NPQIK-HGKIR---VAFTPDEEIG-RGPAHFDVEAFGASF--AYTMDG-GPLGGLEYESFNAAGAKLT------------------------FNGYLPVEE-APEYTEGYEGFYHLLSLNGDVEQSKAYYIIRDFDRENFEARKNNVKNIVKTMQEKYGED-AVVLEMN-DQYYNMLEKIEPVRE-IVDIAYEAMKSLDIEPNIHPIRGGTDGSQLSYMGLPTPNIFTGGENYHGKFEYVSVDTMEKAVQVIVEIA-------  22
  23 --DTQSNEDSHTV-PTTPGQIEFGK-LLVEELKEVGLT-------EVTMD------------D-NGYVMATLPANT-D----KDVPVIGFLAHLDTATDFTGKNVKPQI--HENFDGNAITLNEELNVVLTPEQFPELPSYKGHTIITTDGTTLLGADDKAGLTEIMVAMNYLIH---------NPQIK-HGKIR---VAFTPDEEIG-RGPAHFDVEAFGASF--AYTMDG-GPLGGLEYESFNAAGAKLTFNGTNTHPGTAKNKMRNATKLAMEFNGHLPVEE-APEYTEGYEGFYHLLSLNGDVEQSKAYYIIRDFDRKNFEARKNTIENIVKQMQEKYGQD-AVVLEMN-DQYYNMLEKIEPVRE-IVDIAYEAMKSLNIEPNIHPIRGGTDGSQLSYMGLPTPNIFTGGENYHGKFEYVSVDVMEKAVQVIIEIARRFEEQA  23
  24 GFDTQSDESSTTF-PSTDKQLVLLR-HLSEEMKELGLC-------EVEMD------------E-HGYVMGSIPASP-GC---EHAPVIGFIAHVDTAPDMSGKDVKPQI--IENYNGGDIRL--NEELTMRVADFPELAFFKGHTLITTDGTTLLGADDKAGVAEIMTAAEYLLA---------HPEIK-HGKIR---LGFTPDEEIG-RGVDHFDVERFGAKF--AYTMDG-SMEGELE-----------------------------------------------------------------------------------------------------------VSLELK-DQYYNMREMVEPHPE-IIEKAIAAMKFAGVTAKIQPIRGGTDGARLSYMGLPCPNIFAGGMNFHGKFEYCSLDSMRRAVDTICHLAALWAE--  24
  25 ---TKSNEDSNAH-PSTEGQMVLAK-ELARELKEMGMI-------DVSVD------------S-KAYVMATLPANT-E----NHVPTIGFIAHMDTAPDMSGKDVKPQF--VENYDGKDIILNKEKNIVLKVKDFPEIKDYIGKTLITTDGTTLLGADDKAGVAEIMTAMEHLIN---------HPEIK-HGTVK---IAFTPDEEIG-AGADYFDVEKFNADF--AYTVDG-GTVGELEYENFNAAGVKLTIHGRNVHPGSAKDKMINSITVGNELHSMLPENE-VPEHTEGYEGFYHIVAFNGTVEETKMQYIIRDFDREKFEERKATMQKVVDTLNSKYGEG-TVELKMN-DQYYNMKEKVEPVHH-IVDTAFKAIEEVGLVPKVVPIRGGTDGARLSFMGLPTPNLFTGGHNFHGKFEFIPTFAMSKAVDVILKIIEL-----  25
  26 ---TKSNEDSNTH-PSTEGQMVLAK-ELAKELKEMGMI-------EVSVD------------S-KAYVMATLPANT-E----DHVPVIGFVAHMDTAPDMSGKDIKPKF--IEGYDGNDIVLNEENNIVLKVEDFPEIKEYVGKTLITTDGTTLLGADDKAGVAEIMTAMEYLIN---------HPEIK-HGTVK---IAFTPDEEIG-AGADYFDVEKFNADF--AYTVDG-GAIGELECENFNAAGVKLTIHGRNVHPGSAKNKMINSITVGNELDSMLPQNE-VPEHTEGYEGFYHIVGFNGTVEETKMQYIIRDFDRRKFEERKATMKNIVNALNEKYGKN-TVVLDMN-DQYYNMKEKIKPVYH-IVDTAFKAMEEVGVVPKVVPIRGGTDGARLSFMGLPTPNLFTGGHNFHGKFEFIPTFAMNKAVDVILKIIEL-----  26
  27 -FDTKSSEESSTT-PSTKGQIQLAK-EIAKELKEIGLS-------EVSVD------------D-KAYVMATLPSNM-D----KKVPTIGFISHIDTSPEISGKDIKPQF--VENYDGKDIVLNPEKNIVLKVEDFPEIKDYIGKTLITTDGTTLLGADDKAGVAEIITAMQYLIE---------NPQIK-HGTIK---VAFTPDEEIG-AGADYFDVKKFNADF--AYTVDG-GAIGELEYENFNAAGAKITINGRNIHPGSAKHKMINSMIIGSELISMLPKNE-VPEHTEEYEGFYHLVAFNGSVEETKIQYIIRDFNREKFEDRKTTMKNVVKELNDKYGKD-TVILEVN-DQYYNMKEKIEPVKH-IVDSAFNAMKEVGVVPKVVPIRGGTDGARLSFMGLPTPNLFTGGHNFHGRFEFIPVFAMNKSVEVILKIIDIYSK--  27
  28 -FDTKSSEESITT-PSTRGQIELAK-ELAKELEKMGLS-------EVSVD------------D-KAYVMATLPSNM-D----KSLPTIGFISHMDTSPEISGKDIKPQF--IENYDGKDIVLNQEKNIVLKVKDFPEIKDYIGKNLITTDGTTLLGADDKAGIAEIITAVEYLIE---------NPQIK-HGTIK---IAFTPDEEIG-AGADYFDVKKFNADF--AYTVDG-GAIGELE-----------------------------------------------------------------------------------------------------YGEG-IVKIEVN-DQYYNMKEKIEPVKH-IVDTAFNAMKEVGVVPKVVPIRGGTDGARLSFMGLPTPNLFTGGHNFHGRFEFIPTFAMNKAVEVILKIIDIYSK--  28
  29 KVDTQSSEESDTV-PTTKTQLEFAK-KLGEELKAIGLK-------DVSVD------------E-NGYVMATLESNI-D----KKVPTIGFIAHMDTSPDLSGTNINPRI--VEKYDGQDIVLNKEKNIVLKINEFPEILEYKGQDIVVTDGNTLLGADDKAGIAEIITAMEYLIN---------HPEIK-HGTIK---VGFTPDEEVG-KGADHFDVKKFGADL--AYTLDG-GGIGELECETFNAAKAKVIIEGRNVHPGSAKNKMTNAVLVANKFINMLPENE-VPERTEGYEGFFHLLSVKSEVETAELNYIIRDFDRKKFEERKEQIKEVGKKINEEYNKE-IVCVKVE-DQYYNMKEKIDEVKY-VVDIAYDAMKAIDIEPILVPIRGGTDGSRLSFMGLPTPNLFAGGHNFHGRFEFVPVLSMEKAAELVVKIAELYANR-  29
  30 KVDTQSSEESDTV-PTTKTQLEFAK-KLGEELKAIGLK-------DVSVD------------E-SGYVMATLESNI-D----KKVPAIGFIAHMDTSPDLSGTNINPRI--VEKYDGQDIVLNKEKNIVLKINEFPEILEYKGQDIVVTDGNTLLGADDKAGIAEIITAMEYLIN---------HPEIK-HGTIK---VGFTPDEEVG-KGADHFDVKKFGADL--AYTLDG-GGIGELECE----------------------------------------------------------------------------------------------------NKE-IVCVKVE-DQYYNMKEKIDEVKY-VVDIAYDAMKAIDIEPILVPIRGGTDGSRLSFMGLPTPNLFAGGHNFHGRFEFVPVLSMEKAAELVVKIAELYANR-  30
  31 ---TQSKPGVRQV-PSTEGQWKLLR-LLQAQLEEMGLV-------KVTLS------------E-KGTVMGTLPANV-E----GDIPAIGFISHVDTSPDFSGKNVNPQI--VENYRGGDIALGIG-DEVLSPVMFPVLHQLLGQTLITTDGKTLLGADDKAGIAEIMTALATL-Q---------AKNIP-HGDIR---VAFTPDEEVG-KGAKHFDVEAFDARW--AYTVDG-GGVGELEFENFNAASVTIKIVGNNVHPGTAKGVMVNALSLAARIHAEVPADE-APETTEGYEGFYHLTSMKGSVDRAEMHYIIRDFDRKHFEARKRKMMEIAKKVGKGLHPDCYIELVIE-DSYYNMHEQVIAHPH-VVDIARQAMVDCDIEPQMKPIRGGTDGAQLSFMGLPCPNLFTGGYNYHGKHEFVTLEGMEKAVQVIVRIAEL-----  31
  32 SLDTQSKAGVRQV-PSTEGQWKLLH-LLKEQLEEMGLI-------NVTLS------------E-KGTLMATLPANV-P----GDIPAIGFISHVDTSPDCSGKNVNPQI--VENYRGGDIALGIG-DEVLSPVMFPVLHQLLGQTLITTDGKTLLGADDKAGIAEIMTALAVL-Q---------QKKIP-HGDIR---VAFTPDEEVG-KGAKHFDVDAFDARW--AYTVDG-GGVGELEFENFNAASVNIKIVGNNVHPGTAKGVMVNALSLAARIHAEVPADE-SPEMTEGYEGFYHLASMKGTVERADMHYIIRDFDRKQFEARKRKMMEIAKKVGKGLHPDCYIELVIE-DSYYNMREKVVEHPH-ILDIAQQAMRDCDIEPELKPIRGGTDGAQLSFMGLPCPNLFTGGYNYHGKHEFVTLEGMEKAVQVIVRIAELTAQRK  32
  33 ---TQSNPKSATV-PSTEKQKNLGN-LLVKQLKEMGIE-------NAHID------------E-KGYVYAHLKSNV-E----KNLKKVGFIAHMDTATELTGANVNPQF--VD-YKGGDIKLNDE--FTMSVKEFPCLNEVVGERLITTDGNTLLGADDKSGIAIIMDMVQKIIS---------E-NLP-HGDIS---IGFTPDEEIG-RGADCFDVKKFGADF--AYTIDG-GPIGELEYESFNACSAVVDIKGKNVHPGSAKDIMRNSLMVAHNLLSMLPANE-RPEHTEGYDGFYHLLEMNGDTENTHMEFIIRDFDREKFENKKEYMRKIVEVLNFKYDNS--ISLELK-DSYYNMREKLEDRMD-IIDLAYNSMVEIGITPKIQAIRGGTDGSRLSFMGLPCPNIFAGGFNFHGRYEFVPVSYMEKGSELLVKIVE------  33
  34 ---SQSDADSATV-PSTPGQTELAR-LLAGELKDMGAQ-------AELDD------------D-SGIVYASIPSNV-E----GNVPVIGWVAHVDTAPGVSGSGVKPRI--VRSYDGGDILLNPEQGMVLSPAVFPELTDYLGQDLVVTDGTTLLGADDKAGVAEIMDMAASFLL---------NPERP-HGEIR---IAFTPDEEIG-RGTDAFDVARFGADF--AYTVDG-GALGEIE-----------------------------------------------------------------------------------------------------------VKAEIT-DSYYNMKEKILPHMH-LVEHARRAMEAVGVRPEIVPVRGGTDGAHLSFMGLPCPNLCAGGHNFHGKYEYVPVRSLEKISAILQEIVSGYA---  34
  35 ---TRSDENSTTT-PSTQNQVKFAKNILLPEMEKIGLQ-------DVHYL------------P-NGYCIGTLPAND-P----ALTRKIGFISHMDTA-DFNAEGVAPQI--IENYDGNPITLGTS-GFNLDPKDFPQLKNYLGQTLVTTDGTTLLGSDDKSGIAEIMTSIEYLVA---------HPEIK-HCEIR---VGFGPDEEIG-IGANKFDVEDFNVDF--AYTVDG-GPLGELQYETFSAAAAKIDFIGRNVHPGSAKDQMINAFQLAIDFHNALPEAD-RPEKTDGYQGFYHLMDMTGSVDQAATSYIIRDFEEEDFQARKQVMLDIAENMNAAFDTP-RVIVNLH-DQYYNMKKVIEKDMT-PINIAKEVMENFDIKPIIEPIRGGTDGSKISFMGIPTPNIFAGGENMHGRFEFVSVETMEKAVDVILGIV-------  35
  36 ---TRSDETSATT-PSTQSQVDFATNILIPEMKRVGLE-------NVYYL------------P-NGYAIGTLPAND-S----SFTHKIGLISHMDTA-DFNAEGVNAQI--IENYDGEVIPLGQS-GFNLDPADFASLKKYKGQTLITTDGTTLLGSDDKSGIAEIMTAIEYLAA---------HPDIK-HCEIR---VGFGPDEEIG-IGADKFDAADFDVDF--AYTIDG-GPLGELQFETFSAAAADITFQGRNVHPGTAKGQMINALQLAIDFHNQLPEGA-RPELTDGYEGFYHLMNVEGTVEEAKASYIIRDFDTATFEQRKELMRSIADKMNATLGGE-RVQLELK-DQYYNMRQVIEKDMT-PINIAKAVMEKLDIKPIIEPIRGGTDGSKISFMGIPTPNIFAGGENMHGRFEYVSLQTMEHAVDTIIGIVS------  36
  37 ---TTSDENSESC-PSTKQQLELAK-FLTEELEQIGLS-------QVKMD------------E-NGYVYGLLPATE-GR---ESDTPIGFISHMDTSPDFSGVNPKPQI--IEDYDGEDVLLKGS-GAVLKVEDFPTLKWLKGRTLITTDGTTLLGADDKAGIAEIVTAMEELIEIDRHAESRGYENLSGHGDIW---VCFTPDEEIG-RGADRLDLSYFTAKY--AYTVDG-GYEGDIA----------------------------------------------------------------------------------------------------------SIELELK-HSYSNMLQIIEKTPE-VLERARTAIAAENITPVSDPVRGGTDGAKLSFMGLPCPNLGTGGYGYHGPFEHVTVEGME----TVVRIIKRI----  37
  38 ---TTSDENSSTH-PTTKRQFDLAN-ILVEEMKELGFK-------DVRCD------------E-HCYVYGFIPATK-GY---EDKHSIGLIAHMDTAPAACGENVNPQV--IENYDGGDVILKGN-NSILSPERFPNLKTLKGRTLITTDGTTLLGADDKAGIAEILTACEIIMN----------ENIP-HGKIC---VGFTPDEEVG-QGADFFDVKNFGADF--AYTIDG-GIEGEIA-----------------------------------------------------------------------------------------------------------VKVTLK-EQYRNMVELVKPCFH-LIDNAIEAMKSLNVTPVVEPIRGGTDGARLSYMGLPCPNLGTGGFAYHGEFEHITVEGMDICTNIIIEILKRYA---  38
  39 ---TQSDDTSKTV-PSTPTQHVLAK-MLGQELRDLGLS-------DVKVT------------E-HAYVTAKLPGNN------PTAPCIGLIAHIDTALEVTDDTVNPRI--VENYDGTPIVLDKGGTTVLSPDAFPSLKDHIGSDLIVTDGTTLLGADDKAGIAEIMTAVEYLKD---------HPEIS-RGDVA---VCFCPDEEIG-HGASLLDLKDFGAQF--AYTVDG-TGSDTFNWETFNAARADYHIQGLAVHPGSSKNKMVNANLLAAELIDAFPPAE-TPSHTEDREGFYHLCEMTGGVEEAELHYIIRDHDRQKFESRKAFAELVARQMNERFGRE-VVTVSVS-DQYANMADVLREKPE-IVDTALQAMKDCGITPQVIPVRGGTDGSQLSLRGLPTPNLFTGGYNAHGKYEYAVIQSMEGAVKVLCRIVELFGKR-  39
  40 -VNTQSKEDSETF-PSTPGQLELAN-IIKEDLIGMGF--------DASVS------------E-HGYVYVFIPKNI-D----ADSPKIGFLAHLDTSPEVTAQKVNPKL--VEKYDGNDVVLNPEKNITLSPQKFPILKEFIGNDLIVTDGTTLLGADDKAGVVEIIQAIKEIKI----------ENLP-HGDIY---IAFTPDEEVG-HGVDKIDLSIFKPDF--AYTLDG-EGYGIFEYENFNAALLKYKIHGINTHPGTAKGAMKNAIKISQELMFLFPPLE-TPEATQGYEGFYHFYEINGGVEEVNLKAIIRDHDKTKFQLRKYFAENIANFLNDKYGEG-TVSIEIK-DQYYNMREIIEKHQE-VLDLAKRAFERTGLEFKSKPIRGGTDGARLTYMGIPTPNIFSGGYNYHSIYEFVSVQAMEKAKEVVKNIILLATQK-  40
  41 ---TRSDLNSSAV-PTTKSQLDFLQ-MLKQELKELGFS-------HISLD------------LEDAYLVACIPSNLPEG---KTAPAIGFVAHVDTA-DFNAENIQPQV--HHNYDGKDVLLNAELGLMMRVEGFTNLKNYIGQTLITTDGTTLLGADDKAGLVSILEAAIDLLE---------NPEFP-HGDIW---VAFGPDEEIG-KGAHRFKAERMPAKF--AYTLDS-GVVGKLEYETFNAARAVVKINGTSVHPGQAKDVMVNALAEAAKLFSKLPEQE-VPERTSGYEGFYMLTKQSGNIGMVEAEYIIRDHSMEKFQERKKNFAKIVEKQNKTYDVP-RIECHIY-DEYFNMYEVLKEDMT-SVEVAKEAYRQCGIEPDIQPFRGGTDGCIITFKGIPTPNLFTGAENLHGQYEFVTLESMEKAKEVVLTIIQ------  41
  42 ---TRSDANSQTT-PTTVGQVVLAK-MIETELHELGLA-------DVHYN------------EQNGFLTARLPGNQ-P-----AAKSIGLIAHLDTA-DFSAENIRPQV--ITNYDGQDVLLNQEQGIVLSVAEFPNLKEYQGETLITTDGTTLLGADDKAGIVEILAAVEYFLA---------HPEVA-RGDVW---LAFGPDEEIG-RGADQFDAPNFPVAF--AYTIDS-GRVGHFEYETFNAAQAVITIEGTSVHPGTAYGSLVNAIKLGEQLDQSLPQKE-VPEQTRGNEGFYLLNKFTGSIEKAELVYIIRDHDQENFQARKQFLEKQVQRLNALADKP-RLTITFQ-DQYYNMKEIIEKDWT-PVELAVQAMESCDIEPIITPFRGGTDGSKISFMGIPTPNLFTGGENFHGQYEFITVESMAKAVQTIIAIIRL-----  42
  43 ---TQSDENSTTT-PSTDKQMTFAK-VLEQECREL-FD-------SVILD------------S-TGILYCQLDGDS-------QKDTIGLCAHMDTATECSGANVHPHV--IKEYDGSTIQLNDK--ISMHPDAYPKLAACIGDDLVVTDGSTLLGGDDKAGIAIVLEAIEQLKA----------SNLS-HAPIC---VAFTVDEEIG-RGADQFDLTKFPCAY--AYTVDG-DRIDNVEWENFNAAQAIVHIQGTAIHPGEGKGKLVNASLLAMDFAKCLPNDQ-TPATTCDRQGFYHLVSMQGAVEHAQLVYLLRDHDKTKFARKKLVLQQICDALNDKYGP--RFSVEIK-DQYYNMADFMQDKK--PVEKAKAALLSLGIEPVSIPVRGGTDGARLTEMGLACPNLGTGTFHHHGVYEFASITKMEKMVEVVKTIVT------  43
  44 KVETTSDPTVEDHKPSTKTQWDLAH-MLVKELKDFGIE-------DVTVD------------E-QAYVIANIPATK-GF---EDRATILLCSHMDTSPQCSGKNVNPQV--FRDYDGKDIVVNE--NFTIKIEDNPLLKNAVHDTIITTDGNTLLGADDKAGIANIMTALEYMFK----------TKMD-HGPLQ---IMFNADEETG-NGMFQVPMDKIKAKQ--AYTVDS-TEMPLIEYN-----------------------------------------------------------------------------------------------------------VDIK-FQYANMFDGMGPDAK-PVTILEKACRNAFGEPKESLIRGGTDGSHLTHLGVPTPNMFTGGINCHSRSEMAVLSWMVASTEVVIELIKLW----  44
  45 ---SRENGANGIM-PSSPGQMELAK-LLAVELEALGME-------NIEVR------------D-TAIVTATLPANT-D----DAIPVVSFFGHLDTSAEQTADTKAQRL----HYSGGDLCLNQELKIYLRESEFPELKNYIGDDLLVTDGTSLLGADDKAAIAAIMNALEYLVA---------HPEIK-HGPVK---VGFVPDEEQGLRGAKAFDVAAFGADF--GYTLDC-CGIGEFVYENWNAGDAEIIFTGQSAHPMSAKGKLKNSLLMAHKFIAMLPGGE-APEYTEGREGYYWVKQLQGNSARTVLKLDIRDFTEEGYKARMAYIRQLAVSTCALWGEN-SVVCHLT-DRYANVFNSLQGDAHYPIDIALRAYQKCGITPQPVAMRGGYDGAVLSQKGLPCPNIFTGAHNFHSIYEYLPVRSLRAASDVVVAVIEE-----  45
  46 TTTSRENGAKGIM-PSSPGQMKLAK-LLVSELEALGME-------DIILR------------E-NAIVTATLPANT-D----ETIPVVSFFGHLDTSAEQTADTKAQRL----PYNGGDLCLNPELNIYLRESEFPELKNYIGDDLIVTDGTSLLGADDKAALAAIMNALQFLIS---------HPEIR-HGEVK---VGFVPDEEQGLRGAKAFDVSEFGADF--GYTLDC-CGIGEFVYENWNAGDAEIIFTGQSAHPMSAKGKLKNSLLMAHKFISMLPGGE-APEYTEGREGYYWVKQLQGNSARTVLKLDIRDFSEEGYHARKTFVRQLAESACALWGEG-SVICQLS-DRYANVFNSLQGEGHYPIDIALRAYQRCGITPTPVAMRGGYDGAVLSQKGLPCPNIFTGAHNFHSIYEYLPVRSLRAASDVVIAIIQET----  46
  47 AISSQSDPRATTL-PTTPGQHEMAR-ELADELSRLGLD-------DIVID------------D-HATVTAVKRGNV------PGAPRIGFITHIDTVDVGLSPDIHPQI--LR-FTGDDLCLNSEKQIWLRVAEHPEILAYPDEEIIFSDGTSVLGADNKSAVTVVMTVLENL-----------TPEHR-HGDIV---VAFVPDEEVGLRGAKALDLSRFAVDF--AWTIDC-CELGEIVYENFNAAAAEIRFTGVTAHPMSAKGVLVNPLLMAADYISHFDRLQ-TPEHTAGREGYVWFNGIQGDQNSTLLQASIRDFDSESFLRRKQQIGDVAEKIAAQYPTA-SVEFSIG-DTYSNISNAIGDDRR-AIDLMFEAMESIGVTPKPTPMRGGTDGAALSAKGLLTPNFFTGAHNFHSKFEFLPLRAFEASYHTAFQLCLLAAR--  47
  48 ---TTSNAMSSSV-PSTPTQIEFEK-YLQNELNEMGI-------------------------------KNELTQTGHLFAYLSNSPTLAFFGHVDTSNDAPGKNIKPLIHVVGTE---DIHLPLN-NIILTAKE---LMKYQGKKIITSSGDTLLGADDKCAVAILMTICEMYKN----------KEVP----VV---IVFTPDEEIG-RSITHLDINKLKAKK--AYSLDG-NELGTYSTENFNAINCFVQIEG-TCCPSALLRYLELK-----------PIN--HPSLTKDKEGFVLCTSSKANETKASSSFIIRSFDEKELQHFVQIMNENGKIVESEYPVKVSIEMK---RMYSNIQRFYDCKV--LEDNLINAMKRCGVVPIKKPFRGGFDSCWLCEKGIESINFFSGGINFHSRREFAVVESMVKAVEIVNQLI-------  48
  49 --NSQSNESTHVT-PSTQCQFDMQK-QLQKDLKELNV--------HFTFD------------EKNCILKAELPATN------GSKKSIGFFAHIDTSPEASGEGVKPIIHQLPTEVTSDLALP-S-GTVISKDD---IKKYGGDEIITSSGDTLLGADDKSGVAILMGTLNKIMK----------DNIP-HPRIM---VIFTPDEEIG-ESCDHVCIEDLHLDY--AYSVDG-DELGTYNDEGFNAFGAELTINGYEVHPGEAYNIMEDAGFILSQFYTSLPISK-RPETTKEDEGYILCTEMSGSVIKAHARFIVRSFKINEMEFFIQLMKDQISFLKRRY-TKSSFDLKFT-EQYRNMKRYLPDTL--LVDKLIEAMKLSGVEAKKQYMRGGADCSHLSEKGLPCINMFAGGMNFHSRREFVPVKAINKGVEVLGHLVQLF----  49

     Active site residue:           X

     Metal binding site:            X

     Putative:              +

     Experimental:          #