Alignment for family M17

Family

Summary Holotypes Alignment Tree Genomes Structure Literature H-seq M-seq Architecture

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            4          5                  6          7         8         9        10        11        12              13         14        15        16                             17                      18        19                                                 20        21        22          23          24        25            26                  27                                       28        29          30        31        32                              33        34        35        36        37        38                                                 39        40        41            42                       43        44         45            46                   47                         48           49           50        51        5
     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   1 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGSFMAVAQGSD----EPLRFIVLQYSGA--------PKAQA---P----VV---------------------------LVGKGITFDSGGISIK--PAAEMDEMKFDMSGAASVLGTFRTLAEL------------------K---PA-INVIGLIPACENLLNGKAVKPGDVVTSMSGQTIEILNTDAEGRLVLCDALTY-AE-----------------------RF--KPAA---------------VVDIATLTGACMVALGGVRSGLFAN----KPELGDALFHAG---------------EISGDLCWRLPLDDDYAEGL-K-TNFADV--AN-VA--GRAGG-----------AITAAKFLQRFT-DK---------------YS-WAHLDIAGT--AW-KSGG----AK-GA--TGRPVPLLVEFLLS------   1
   2 ------------SACIVVGVFEPRRLSPIAEQLDKISDGYISALLRRGELEGKPGQTLLLHHVPNVLSERILLIGCGKERELDERQYKQVIQKTINTLNDTGSM----EAVCF-----LTELHVKGRNNY-WKVRQAVETAKETLYS----------FDQLKTNKSEPRRPLR------KMVFNVPTR-REL--------TSGERAIQHGLAIAAG-----------------------------------------IKAAKDLGNMPPNICNAAYLASQARQLADSY----SKNVITRVIGEQQMKELGMHSYLAVGQGSQ----NESLMSVIEYKGN--------ASEDAR--P----IV---------------------------LVGKGLTFDSGGISIK--PSEGMDEMKYDMCGAAAVYGVMRMVAEL------------------Q---LP-INVIGVLAGCENMPGGRAYRPGDVLTTMSGQTVEVLNTDAEGRLVLCDVLTY-VE-----------------------RF--EPEA---------------VIDVATLTGACVIALGHHITGLMAN----HNPLAHELIAAS---------------EQSGDRAWRLPLGDEYQEQL-E-SNFADM--AN-IG--GRPGG-----------AITAGCFLSRFT-RK---------------YN-WAHLDIAGT--AW-RSGK----AK-GA--TGRPVALLAQFLLNRAGFNG   2
   3 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNTFLAVARGSR----EAPRFVILEYRGA--------EASRA---P----IV---------------------------LIGKGITFDSGGISIK--PAGAMDEMKFDMCGAASVIGTIEACARL------------------E---LP-LNLVAVVPACENLPGGRAIKPGDIVSSMSGRTVEILNTDAEGRLILCDAITW-AK-----------------------SL--APEI---------------IIDVATLTGACVAALGAHASGLFSN----HQPLADALLQAG---------------EDSGDRAWQMPLWPEYERQL-K-SRFADV--AN-IG--GSKAG-----------AVTAAAFLGLFA-KD---------------ES-WAHLDIAGT--AW-KSGK----DK-GA--TGRPVGLLCRYLIDRANQEP   3
   4 -----------CAALLVGCREDNPLEDSLLARIDQLLQGAIASLVQSREITGELNRVTILHTLGRLPAERIVLVGLGNSGALTSDRLRQVGGSAVKALKGAGVT----RAASV-----VHRAAGVPPTSV-ADIAQGLSLGD---YS----------FDIYKT-KPGTTVPVT------ELVNLFEPG-TDT--------ADAERLLAADATICEA-----------------------------------------VSFARDLVSQPGNVATPLFLAEKALEF--SA----RLGIACTVLDRDEMERQGMEGILSVAKGSH----QLPRFIVLEYRGG--------SADKR---P----TV---------------------------LVGKGITFDSGGISLK--PREGMERMKDDMAGAAAVMGAVMAVAGL------------------R---LP-VNVIGLIPAAENLPGGGAYKPGDIVRTMSGQTVEIVNTDAEGRMILSDALFY-AQ-----------------------RF--KPAA---------------VIDLATLTGACLVALGSAVSGVMGN----DAALVKLLRRAG---------------EATGERLWELPLWDEYGEIM-K-SDVADL--KN-AG--GPHAG-----------TITAAWFLQRFV-GK---------------SR-WAHVDIAGT--AW-EEKGRPYQPK-GA--TGVGVRLLVEYLKATVR---   4
   5 ---------------------------------------------------------------------------------------------------AMGAV----LASYI-----YTRTRSVDEKDP-QWQVQGLF----------------------------------------------------C--------TSHETDFQEGMAIAAS-----------------------------------------MNFTRELGDLPGNIVTPASLAQTATQL--AQ----QFGFECTVIDQEEAAKLGMGAFYSVGKGSA----QPGKMIIL--RNT--------SPEKKA--P----LM---------------------------LVGKGLTFDTGGISIK--PSASMEEMKYDMCGGAAVLGAFHLMGSL------------------G---IR-KDVVGIVPAAENMPSGTANKPGDIVTACNGKTIEVINTDAEGRLILCDALAHGTK-----------------------TY--QPSA---------------IVDIATLTGACVVALGSHAIGVISN----NDEYAREVTAKG---------------ATLHERLWQLPAYAEYDEQL-K-SDFADM--QN-VG--GKEAG-----------TITAGLFLQKFV-PE---------------NTPWVHLDVAGT--AW-DGKKEYFHKK-GA--TGSGV---------------   5
   6 -----------------------------------------------------------------------------------------------------------------------------------------SETIKVDNLCVHLCTSKEITIEQIKA--------------------------------------------NRAQTFTEC-----------------------------------------ANYARDLGNAPGNALTPKILAEKARELAKET------ESEIEVLGETDMEKLGMGALLSVSQGSS----EEAQLITLKHTHP------------SASKT----VA---------------------------IVGKGLTFDAGGTSLK--PSKGMQDMKFDMCGAAAVLGAFKAICEC------------------N---AA-INVVCVVPSSENLINGDATKPGDIVTSYSGKTIEIYNTDAEGRLILCDAMAYTVE-----------------------KH--KPDV---------------MVDVATLTGAAIVALGHEMAAVISE----DEELQGELIEAG---------------KQVHERLWPLPINDDYKSLL-K-GKDADL--CN-IG--PPYAG-----------TVTAACFLSNFT----------------G-DTRWAHLDIAGT--AW-GMKGCSYINENLA--SGFGARLLAKWLM-------   6
   7 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MNGLLAVNEGSD----EEAKLLFLEYLPS--------KGAKDPYHV----L----------------------------VVGKGVLFDSGGLSLK--PAKGMEEMKMDMSGAAVALASILAIAEL------------------Q---LP-IRWTVALPLTDNMPSSKAIKVGSVVSMYNGKTVEILNTDAEGRLILADALSYCTE-----------------------KY--NPNC---------------VVDIATLTGSIMSALGSEYAGLFSN----DKKLADLLTQSG---------------DAVGEKLWQMPLDENYKKLL-K-SNIADL--KN-IG--GAFAG-----------SITAAKFLQDFV-GG---------------AK-WAHIDIAGV--MS-QATRSGYRSE-GA--RGFGVRMLCEFAKRCYQ---   7
   8 ---------------NADILVQFFSKKEMKRDAGKVLAGLGVVASPDGDFKASAGEIAMLYRQASGKEASRVILAGVGEGKTAEDYRKAADSVARKTVDLHLGV----LALDCSPIDDWAKQSKQKPEELAAILVEGVLSGA---YR----------FDRLKSGKLDKEETKEDKPKNIEELVLAGCG-SRL--------EAIEKGAGKGMIIGAC-----------------------------------------QNRARDLVNLPGNHLSAEDLAEAAIEA--GK----RGGFEVTVFDKKKIVELGMGGLLAVNKGSE----QPPTFVILDYKPK--------GKAKK---T----IA---------------------------LVGKGVTFDSGGISLK--PAQGMDEMKSDMSGAAVVIAAIEAAASL------------------G---LP-LRVVGLVPATDNMPGGSAQKPGDVITTMSGITVEVGNTDAEGRLILADALFYAKK-----------------------EY--NPDV---------------IIDLATLTGACIVALGNSVAGLFSN----DEKLAESIFEAG---------------QSSGEKVWRLPLWDEYDELI-K-SDVADV--HN-TG--GRGAG-----------TITAAKFLEKFI-DG---------------HKHWAHIDIAGP--AF-WAKG-GSKTP-GA--TGFGVRLLLDLLKGWS----   8
   9 --------------------------------------------------------------------------------------------------------------------------------------QTFIEGIYFGNYS----------FDKYKTEKKSP--------KPLEVFFYAENE------------KKVKNAISTATNLMNA-----------------------------------------VYFVRDLQNEPSNELTPELLAKRISSEAKKS------GIRCTVFDEKEIAKRNMGGLIAVGKGSI----NKPRFIILEYKPV----VKAAKAKKTKLKK----IA---------------------------LVGKGMTFDSGGISLK--PSKSMSEMKNDMAGASVVAGAVIAAAKN------------------K---LP-IHLFGIIPTAENMPSGEAFKPGDIIKTASGKTIEVDDTDAEGRVILADALDYASK-----------------------L---KPNQ---------------IIDLATLTGACVVALGEFVAGLFSK----NDELAEKLYKSG---------------LKTFDRVWRLPLWDDYHKLN-E-SSVADV--KN-LG--GRWGG-----------AISAAKFLENFV-DK---------------KIHWAHLDIAGP--SI-HNDSRNYTKK-YM--TGFGVRLLFDYL--------   9
  10 ------------------------------------------------------------------------------------IVIGAGKATGLKANDFLKFGGVAAGKLSATAAAMTIMAELPDGAMTSEQAVAIAAGLRLRAYK----------FDRYKTKKKDGEEGGSRADISLAV--------GDV--------AAAKKAFASAGHVVDG-----------------------------------------VIIARDLVNEPPNVLFPEEFARRASLL---R----KLGVKVEVLDVKAMDKLGMGALLGVGQGST----RPSRTVIMRWDGG-----------KKGEAP----VA---------------------------FVGKGVCFDTGGISIK--PAGSMEDMKGDMGGAACVVGLMHALAAR------------------K---AK-ANVVGAIGLVENMPDGNAQRPGDIVTSMSGQTIEIINTDAEGRLVLADVLWYVAK-----------------------KT--KPKF---------------MVDLATLTGAIVVALGTEHAGMFSN----NDELADRLLTAG---------------IESGEKVWRLPLGPEYDKLI-D-SQFADM--KN-TG--GRHGG-----------SITAAQFLQRFV--D---------------GTPWAHLDIAGT--AM-GAPKTDINQS-WG--SGYGVRLLD-----------  10
  11 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LEKEGMNMFLSVGQAGV----CPPRLVILEYKGN-----------PDSDEK----VA---------------------------LVGKGITFDTGGLNLK--PTGAIEDMHTDMCGSAAVLGAVRAASRQ------------------G---LK-VNIVCALALAENAIGSKAVKPLTIVKSHKGITVENNNTDAEGRLVLGDAMSYVQK-----------------------EY--KPKK---------------IIDVATLTGACMVALGEHCAGLFSN----SDDLAKKLQETG---------------TECHERCWRLPILPEHTAAL-KGSQ-SDS--RS-TGR-GRYGG-----------ASTAAAFLQQFV-YE---------------GIDWAHLDIAGP--SN-YSSPKSYFPK-GA--TGFGVQLLYTYLKEHEQ---  11
  12 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDK-SLQSLTLALPEA-TDA--------NAAEAGLREGIALGES-----------------------------------------QNLTRTLVNEPGNRLTPTLLGEQAKKM--CA----EQGLRCQVYSSEKLHELKMGSFWSVTQGSD----EPPALIVMEYTPE--------GAAEGP--V----LG---------------------------LVGKGITFDSGGLSLK--PADSMEKMKYDMAGAAAMIGAMRAIALL------------------K---PR-IKVISVICSAENMPSGKAQKPGDVQISMIGKSIEVLNTDAEGRLVLADGLAYAKQ-----------------------LG--ATH----------------LIDAATLTGAVMVALGGVNAGVFCN----DEEAWQHFEAAL---------------GQSGEKFWRLPLDEEYREML-R-SPIADI--KN-VG--GRYGG-----------ASTAAMFLKEFV-GD---------------TP-WVHLDIAGT--AW-MDEAKPWMSS-GP--SGIAMPSIVEWV--------  12
  13 ------------EVQTGDLLGVTADLAVLLYAEDETLPSAVAALCEPEDTTGRWQSQTLIYPRGALPARRLLLIGMGKRSAITADTVRQAAALAVRYAQDAKVA----TFHIG-----YNGNLPLTPAVFGQAFAEGSVLGA---YR----------YTRYKSDAKEQPTQKA----------VLQAA-TDA--------DAAAAGVRRGQIIAQA-----------------------------------------TAFARDLANGPGNDVTPAFLGQTALAL--GE----RYGLKTMVLDKAQLIEQGFGGILAVGQGSA----NEPRFIVMEY--G--------SPDQGP--P----IC---------------------------LVGKGITFDTGGISIK--PAEKMDDMKMDMSGAAAVFGAMQAVAEL------------------Q---LP-LYVVGIVCAAENMPSATAYRPGDIIRTLSGKTVEVLNTDAEGRIVLADGLFY-AQ-----------------------RY--QPAA---------------IVDLATLTPVRII---------------------------------------------------DSP-----------------------------------------------------------------------------------------------------------------------------  13
  14 ---------------------------------------------PEKDRRARVAEITVIAPAGDVSA----------------------------------------------------------------------------------------------------------------------------------------SGFAVGVAMAEG-----------------------------------------QAIAKRLGQMPGNVCTPDTFAEVGREI--AE----RHGMQLTVWGREQLAAANMGSFLSVAQGTS----QDPKLVALEHRGG--------PADQK---P----VV---------------------------LIGKGLCFDTGGISIK--PAPEMEWMKFDMSGAGGVMGAMETIGRL------------------K---LP-VNVVGIIGSTTNMPSGEAVKPGDVVRASNGKTIEIINTDAEGRLVLADLLVF-AK-----------------------RF--DPAI---------------AIDAATLTGAIVIGLGHNAVGVFGN----EQAAIDEVLNAG---------------QAAGEPGWALPLWEDYKEQI-K-SDVADL--KN-TG--GRAAG-----------SITAALFLQEFV-DG---------------YP-WVHLDVAGT--AY-SQSDLGWIPK-GP--TGTPVGTFVEIV--------  14
  15 ----------------------------LKKKIDAALSGEFSRILDEGVFRGERGDVMILPTLGKMSPQNLVLAGLGNRDSLTTEGLRRVSGQVAKAASKRRIK----TLLST-----LSGALKDVALSS-EAVVEGTLLAL---YR----------FDLYKTAGKDKDEPKVPA-QPLEALWIASSK-EGE--------KKHGRGISVAKAVVRG-----------------------------------------VYLARDLGNHPANVATPSMISETAAKE--AA----ARKISFVSYDFQTISQMGLGALAGVAKGSL----EPARLIRLEYKPK--------KAINKN--P----VL---------------------------LVGKTLTFDSGGISLK--PAEKMEAMKGDMSGGAAVLGTMMACADL------------------D---IP-LHIVGIMPATENMPSGTANKPGDVLTAFNGKTIEVINTDAEGRLILADALSWGIK-----------------------TF--HPEL---------------TIDLATLTGAVTVALGSHAIGVLGN----NRDLVARALEAG---------------EVSGERGWELPLFEEYYEQI-K-SPIADM--QN-VG--GRGAG-----------TITAAAFLSHFV-DD---------------CP-WLHLDIAGT--AW-VESDEPYKPK-GN--VGVGIRLLVHLL--------  15
  16 --------------------EDKKDL-------------------------------------------------------------------------------------------------PL------------------------------------------------------QSIDIIG--------------GEESAGLDAAKAVASG-----------------------------------------VSLCRDLVNSPPNMLTPGALADAAAKIAEDH----G--LECEILEEEEIVALGMGAYMGVAQGAV----FPPKFIHLTYKPS--------GTPKK---K----VA---------------------------LIGKGLTFDSGGYNIKAGAGSMIELMKFDMGGSACTLGAAKAIGQL------------------K---PDGVEAHFIVAACENMVSEKAMRPGDILTASNGKTIEVLNTDAEGRLTLADALVFAEK-----------------------L---GVDA---------------IIDSATLTGACLIALGTDYAGMWSS----DETLAKELTDVG---------------AETGEKLWRMPLAPEYGDQV-K-SKIADL--KN-VG--ARPGS-----------SITAALFLKEFV-EK----------------TPWAHLDIAGP--VW-KDE-----AG-GA--TGYGVRLLTRWVQ-------  16
  17 -----------GDSLAIGLFEDAVELTGELATLDQKFSGVLKELIAEEEFKGKANSTIFTRVNP---GRPVRKLILVGLGKPDALKLDTLRRAAAAVA----------RVAKKQKSKILGFSFPLWNNDPAASAQAIAEGVELALYQ----------DIRFKS-------EPEDKGSQIETVDLLGFS------------GQEAA-ITLANQIVSG-----------------------------------------VNLARELVAAPANAVTPITLAETAQAIAKDY----G--LQVEILEKEDCEKLGMGAFLGVAQASE----LPPKFIHLTYKPE--------GTPKK---K----LA---------------------------IIGKGVTFDSGGLNIK-GAGSGIETMKMDMGGAAATLGAAKAIAQI------------------K---PD-VEVHFISAVAENMISGRAMHPGDILTASNGKTIEVNNTDAEGRLTLADALVYAEK-----------------------L---GLDA---------------IVDLATLTGANVIALGDDIAGLYTP----DDDVASQIEKAA---------------QTSGEKIWRMPMEEKYFEGL-K-SGIADM--KN-TG--PRPGG-----------AITAALFLKQFV-KE----------------TPWAHLDIAGP--VW-TDKENGYNGA-GA--TGYGVRLLVNWVLGIGE---  17
  18 -------------------------------------------------------------------------------------------------------------------------------------AQAVLEGI----YH----------DVRFKS------GDDKEKGCLLESLEVIASN------------DEERC--KILTVCSSG-----------------------------------------VKMARDLVGAPSNYVTPSTLAETARNIAKEH----G--MSCTILERDECERRGMGAYLAVSRGSA----QPPKFIHVTYKPK--------GEVKK---K----IA---------------------------IVGKGLCFDSGGYNLKAGAGSMIELMKFDMGGSAATLGCAKAVGMM------------------K---PEGVEVHFIVAACENMISSDAMRPGDILTASNGKTIEVLNTDAEGRLTLADALVYAEQ-----------------------A---GAQE---------------IVDIATLTGACIISLGDEYAGLWSN----DETMGKEDFLLQ---------------VVTG---------------V-Q-ELLSSF--TT-SG--EKGGG-----------SITAALFLKEFV-KE----------------AKWSHLDIAGP--VW-N----------------------------------  18
  19 --------------------------------------------------------------------------------------------------------------------------------------------------Q----------YINFS-----------------EGIDIIGTS------------HSLSANLTKIWSTCSG-----------------------------------------VELSRQLVAAPAKIITPQALADTATNIARDF----N--LDIKILEREECQALGMGSYLAVGQGSS----LPPKFIHITYTPK--------GLINR---R----VA---------------------------IVGKGVTFDSGGYNLKVGA-SKIEMMKYDMGGSAAILGTARSIAEL------------------Q---PVGVEVHMIIAACENMISGSAIHPGDIVVASNGKTIEITNTDAEGRLTLADALVYACH-----------------------L---KPDS---------------IVDIATLTGASVIALGEEIAGLWST----SDHLAAELVQAG---------------EQGGELLWRMPLHYPYRKGM-R-SLMADM--KN-TA--SRAGS-----------SITAALFLKEFI-SP---------------GIEWAHIDMAGT--VW-SEKGRNQDPP-GA--TGFGVRTLVNWI--------  19
  20 -------------------------------------------------------------------------------------------------------------------------------------AAAIASGTVLGLHV----------DSRYRS---------EPNNVHLKHVDLIGLG--SG--------PELERKLQHANYVSSG-----------------------------------------VIFGKDLVNSPANVLTPVVLAEEASKIASTY----SDVFTATILDAERCKELKMGSYLGVAAASA----NPPRFIHLCYKPP-------GGNVKR---K----LA---------------------------IVGKGLTFDSGGYNIKVGAICSIELMKWDMGGSAAVFGAAKALGQI------------------K---PPGVEVHFIVAACENMISGTGMRPGDIVTASNGMTIEVNNTDAEGRLTLADALVYACK-----------------------Q---GVDK---------------IIDLATLTGYCRIALGLSIAGIFTP----SDELDKEVAAAS---------------EVSGEKFWRLPLEESYWESM-K-SSVADM--VN-TG--TPQGG-----------AITAALFLKKFV-DE---------------KVQWMHIDIAGP--VW-SHK-----NR-SA--TGFGVSTMVEWVLKNS----  20
  21 ---TGDVLAVAVTEKDLSKGSDSKFENALLNKLDSQLGGILSEASAEEDFTGKAGQSVVLRLSGQGFKRVGLIGLGQNAPSTTSACRGIGESIASVAK----------SAQASSAAVLLASPGGIQQEFKLNAAAAIASGTVLGLHE----------DSRFKS---------DSKKVHLKQVDLIGLG--SG--------PEVDQKLKYANDLSSG-----------------------------------------VIFGKELVNSPANVLTPAVLAEEASKIASTY----SDVFTATILDVEKCQELKMGSYLGVAAASA----NPPHFIHLCYKPV-------GGNVKR---K----LA---------------------------IVGKGLTFDSGGYNIKTGPGCSIELMKFDMGGSAAVFGAAKALAQI------------------K---PPGVEVHFIVAACENMISGTGMRPGDIVTASNGKTIEVNNTDAEGRLTLADALVYACN-----------------------Q---GVDK---------------IIDLATLTGACVVALGPSIAGIFTP----SDELAKEVTAAS---------------EVSGEKFWRLPLEESYWESM-K-SGVADM--VN-TG--GRQGG-----------SITAALFLKQFV-DE---------------KVQWMHIDMAGP--VW-NDK-----KR-AA--TGFGVSTLVEWVLKNS----  21
  22 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKPSLKSVDIIGFG--SG--------PELEKKLKYAEHVSYG-----------------------------------------VIFGKELVNSPANVLTPAVLAEEALNLASMY----SDVMTANILNEEQCKELKMGSYLAVAAASA----NPPHFIHLIYKPS-------SGPVKT---K----LA---------------------------LVGKGLTFDSGGYNIKTGPGCLIELMKFDMGGSAAVLGAAKAIGQI------------------K---PPGVEVHFIVAACENMISGTGMRPGDVLTASNGKTIEVNNTDAEGRLTLADALVYACN-----------------------Q---GVDK---------------VVDLATLTGACIIALGTSMAGIYTP----SDKLAKEVIAAS---------------ERSGEKLWRMPMEESYWEMM-K-SGVADM--VN-TG--GRAGG-----------SITAALFLKQFV-SE---------------DVEWMHIDMAGP--VW-NEK-----KK-AA--TGFGVATLVEWVQNHSSS--  22
  23 ----GDILVVGVTEKDLAKDGNSKFENPILSKVDAHLSGLLAQVSSEEDFTGKPGQSTVLRLPGLGSKRIALIGLGQSV-SSPVAFHSLGEAVATVSK----------ASQSTSAAIVLAS--SVSDESKLSSVSALASGIVLGLFE----------DGRYKS---------ESKKPSLKAVDIIGFG--TG--------AEVEKKLKYAEDVSYG-----------------------------------------VIFGRELINSPANVLTPAVLAEEAAKVASTY----SDVFTANILNEEQCKELKMGSYLAVAAASA----NPPHFIHLVYKPP-------NGSVKT---K----LA---------------------------LVGKGLTFDSGGYNIKTGPGCSIELMKFDMGGSAAVLGAAKAIGEI------------------K---PPGVEVHFIVAACENMISGTGMRPGDVITASNGKTIEVNNTDAEGRLTLADALVYACN-----------------------Q---GVDK---------------IVDLATLTGACVIALGTSMAGIYTP----SDELAKEVIAAS---------------ERSGEKLWRMPLEESYWEMM-K-SGVADM--VN-TG--GRAGG-----------SITAALFLKQFV-SE---------------KVQWMHIDMAGP--VW-NEK-----KK-SG--TGFGVATLVEWVQKNSSS--  23
  24 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKPSLKSVVFIGFG--TG--------PELENKLKYAEHVSYG-----------------------------------------VIFTKELVNSPANVLSPAVLAEEASNLASMY----SNVMTANILKEEQCKELKMGSYLAVAAASA----NPPHFIHLIYKPS-------SGPVKT---K----LA---------------------------LVGKGLTFDSGGYNIKIGPELIIELMKIDVGGSAAVLGAAKAIGEI------------------K---PPGVEVHFIVAACENMISGTGMRPGDVITASNGKTIEVNDTDSEGRLTLADALVYACN-----------------------Q---GVDK---------------IVDIATLTGEIIVALGPSMAGMYTA----SDELAKEVIAAS---------------QRSGEKLWRMPMEESYWEMM-K-SGVADM--VN-FG--GRAGG-----------SITAALFLKRFV-SE---------------NVEWLHIDMAGR--VW-NEK-----KK-AA--TGFGVATLVEWVQNNSS---  24
  25 ----GDLLAIGATENDMARDENSKFKNPLLQQLDSELNGLLSAASSEEDFSGKSGQSVNLRFPG---GRITLVGLGSSA-SSPTSYHSLGQAAAAAAK----------SSQARNIAVALASTDGLSAESKINSASAIATGVVLGSFE----------DNRFRS---------ESKKSTLESLDILGLG--TG--------PEIERKIKYAEHVCAG-----------------------------------------VILGRELVNAPANIVTPAVLAEEAKKIASTY----SDVISVNILDAEQCKELKMGAYLAVAAAATE---NPPYFIHLCFKTP-------TKERKT---K----LA---------------------------LVGKGLTFDSGGYNLKVGARSRIELMKNDMGGAAAVLGAAKALGEI------------------R---PSRVEVHFIVAACENMISAEGMRPGDIVTASNGKTIEVNNTDAEGRLTLADALIYACN-----------------------Q---GVEK---------------IIDLATLTGAIMVALGPSVAGAFTP----NDDLAREVVEAA---------------EASGEKLWRMPMEESYWESM-K-SGVADM--IN-TG--PGNGG-----------AITGALFLKQFV-DE---------------KVQWLHLDVAGP--VW-SDE-----KK-NA--TGYGVSTLVEWVLRN-----  25
  26 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPTASRLASLTVVGSG-LEG--------AQADTAIKRGEAVARG-----------------------------------------NLLTRYLVESPPNVCTPSHLAATAAHIAAVA----PEVFSLKVYEQSECEAMNMGLFLGVSEASA----EPPKFIHLKYSPK-------GGSASR---K----IA---------------------------IVGKGLTFDSGGYNLKAGGGSSRALMKFDMGGAGATLGAARILADL------------------Q---PADVEVHFIIAACENMVAGAGLRPGDILTSASGKTVEVNNTDAEGRLTLADAMWFAQK-----------------------C---GATA---------------VVDVATLTGACIVALGTQIAGLFTP----SDDMAAALTAAS---------------KAAGEKLWRMPFETDYSDDL-K-SPVADM--KN-TG--SRYGG-----------AITAALFLKQFV-NE---------------GVEWAHVDVAGP--VW-NDK-----LG-LP--TGYGAALLSEWAL-------  26
  27 ------------------------------------------------------------------GSKAKRYAIVGLGTTPKSDDDSAKDSYAEAGSSLGKAIANKCHAEKKVGAVTVVLPSVLASD--ATIMKDFATSFYQTLYA----------DNRYRTGAKVKKPAEDLKSVT----ILSEGG-EPV--------DA--SVIEAGKKLATG-----------------------------------------IFLTKDIVNAPHNVLNSLSLAETAKRIAEQS----GGRITCEILDKKACEARCMGGFLGVARGSE----TPPQFIHLTYTPP-------SGKISK---K----VG---------------------------VIGKGLLFDTGGYNIK---TAMMELMKFDCGGAAAVLGAARAIGAL------------------Q---PEGVEAHFVVAACENMINEKAMVPSDILTASNGKTIEVMNTDAEGRLTLADALVFCDK-----------------------EI--GCES---------------IIELSTLTGACMISLGKQICGVWTD----NDELAKEIEDIS---------------KKTGDKSWRMPMAKEYNELL-E-SKFADL--KN-IG--TRYGG-----------AITAALFLQNFV-SK---------------KKPFAHIDIAGP--VW-SDK------D-GA--TGFGAKLVTEWVTR------  27
  28 --------------------------SLQLARINAKYDGAIDRLLEEATNFTIGDKTAIMTYNTASGQKPQTLIIIHVGAT-------AADA-RKVGTDLARTI----QGGKKAKSCAILLPNQKSTREASAYVTEMTTALWVGLYK----------DKRFKS---IKDDTDDAGNVNTIDLIVPDGN-YDR--------ETIRNAIANGRTHSAA-----------------------------------------VYLSKDIVNAPHNVLNSVSLVDTAQRLNKMY----KRTLRCQILDQEECQRRGMGAYLGVARGSE----TPAQFIHITYRPPKSTYWSKSAPKLR---R----LG---------------------------IIGKGLLFDTGGYNIK---TSMMELMKFDCGGAAAVLGAVRAIAEL------------------E---PRGVEVHFVIAACENMINERAMVPGDILTASNGKTIEVVNTDAEGRLTMADALVYVDQ-----------------------EL--DCDE---------------ILELSTLTGACMISLGTSIAGLWTN----NDQLAVRLLESS---------------ARTGEKIWRMPMEADYRDAL-K-SKVADL--KN-LG--ARYGG-----------AIHAALFLQEFV-EG---------------DKPFAHVDM-------------------------------------------  28
  29 --------------------------------------------------------------------------------------------------------VVLSLVTMLHDNKLSKLTVVFEINVDKNLFRFFLETLFYEYMT----------DERFKS---------TDKNVNMEYIKHLGVYINNA--------DTYKEEVEKARVYYFG-----------------------------------------TYYASQLIAAPSNYCNPVSLSNAAVELAQKL----N--LEYKILGVKELEELKMGAYLSVGKGSM----YPNKFIHLTYKSK--------GDVKK---K----IA---------------------------LVGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYCVGTL------------------K---PENVEIHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEK-----------------------L---GVDY---------------IVDIATLTGAMLYSLGTSYAGVFGN----NEELINKILNSS---------------KTSNEPVWWLPIINEYRATL-N-SKYADI--NNISS--SVKAS-----------SIVASLFLKEFV--Q---------------NTAWAHIDIAGV--SW-NFK-----AR-KP--KGFGVRLLTEFVLNDAL---  29
  30 -----------------------------------------------------------------------------------------------------------------EEKALTLRLPGV-----------------------------------------------------------------------------TEGVLERARKVAEG-----------------------------------------VYLARDLVNEPPNLLTPEALAERALE-LRAL----G--VEVEVLDEEAIASLGMGAFLAVAQGSE----NPPRFIRLRY-AP-------PGA-RA---R----LD---------------------------LVGKGLTFDSGGYSLK--PTESMTTMKGDMAGAAAVLGAMKSAALL------------------G---LP-VEIRGYIAACENMISGRAYRVGDVLKTFSGKTVEVMNTDAEGRLTLADALFYAER-----------------------E---GAER---------------ILELSTLTGAAVVALGEEVAALFAT----ELAWGSLVQEAA---------------HRAGEKVWPMPLEKAYREKL-K-SPVADL--KN-VG--DRNGG-----------AITAALFLSEFV------------------RVPLAHLDIAGP--AF-AKKGHPLGPE-GG--TGFGVRTILEVAQAL-----  30
  31 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QAVDRGTILGES-----------------------------------------INLAREMVNRHAGDIFPVSFADRVVEV--AK----STGLEAEILDENQLKQEKMGSMLAVAQGSD----QPARLAILKY-----------QGADASAPT----LA---------------------------LVGKGVTFDSGGLSLK--PSDGMKTMKCDMGGAAAVLGAMNAIAQL------------------K---LP-VNVIGYMGLVENMVNGSSYKLGDVLTARNGKTIEVLNTDAEGRLVLADVLSFAVD-----------------------RG--AAN----------------IIDLATLTGACVVALGEEVTGVFAN----NAEWSQVVQDAA---------------QASGEDVWELPMFPQFADQL-K-SDVADL--KN-VG--TRWGG-----------AITAAKFLENFV-SE---------------TP-WVHLDIAGP--AF-ASANAPHREG-GG--TGCMVKTLV-----------  31
  32 --------------------------------------SQPAVSVLYSAHATHNPAAVARPHPAFRRQHGRGGPSGTWPQARRSSPEHARRGKRRSAGPCPHQCRRRPRSRPGAGRAGPQTEREVLRVEACEFPAALASAAAVAGWQ----------DRRYKGQAAQDEETESTGEMQLHVS------------------GLSAEEQQRTEGLLRG-----------------------------------------VTFARELTSAPANVLNPATLAREARGLASEH-------LQVEIWDESDIQARGMGLLLAVAAGSD----LGPRLIRLTLPAR-----------GEKRRV----IA---------------------------LVGKGITFDTGGYSLK--TSAGMYGMKNDMGGAAAVLGAMAALAEL------------------REQVPEGVEVRAYVAAAENMVGPRAMRPGDIYRAANGKTVEVTNTDAEGRLVLGDALTVACD-----------------------E---GATE---------------VIDLATLTGVKVSALGNDMAALFCN----DRALAAGLEQAA---------------ESAGEMVWELPLHRPYLRGY-QKNTLADL--KN--SDMQPAGA-----------SIKAALFLQEFV------------------TRPWAHLDIAGN-----AEKDS------VA--TGWGVGTLVEYVLAQG----  32
  33 --------------------------------------------------------------------------------------------------------------------------------------QAAAEGILLGDYC----------FDKYRTAR--PKYAGPEEVFL----------------------DGTEIGLKRAGAFAGG-----------------------------------------QIRSRSLANEPGNVIGPAEMAHCAQEVARAG------GLECTVYDEGQIHEMGMEALFAVGRGSA----KRPRFVHMVYRPQ---------GIENPK-R----VV---------------------------FVGKSVTFDSGGLSIK--TRDGMITMKGDKTGACNVLGIMEAVAAL----------------------RPSLEVHGIFGAVENMPDGDAYRVDDIIRAKNGKTIEVKNTDAEGRLTLADALAYACE-----------------------L---KPDA---------------LIDMATLTGAIGTALGGYTAGALGD----DAALAQAIIDAG---------------KAVGERFHYFPLDDDKLKEK-ISTPFADV--KN-SA--GPGGG-----------AITAGMFLREFV---------------VP-GTSWIHLDIASV--DY-YESAFDCYSA-GA--SSFGVRTCLQYLMNLEK---  33
  34 --------------------------YKGKSVAVFVYEGDLKPLARLSKGTSNKAKRVAELENFKGKEGEILKVPTLGTSVDFVYIVGLGKKEKVGEDTYRRASANLVKRMRRDKVESTVVVIPRRGDVSKEITKAITEGAILGNYR----------FDKYKSKKEDEKFEIKEVLIN----------------------RGDEEGIRLGKIFAEA-----------------------------------------QNYARNLVNEPGNVINPITLAEEAKKLAEEF------GLECKVYDEKQIQEMGMMALYSVGKGSA----TPPRFIHLIYKPS---------G--KPKEK----IA---------------------------LVGKGLTFDSGGLNIK--PGDYMRTMKMDKSGACAVLGIMRAIAQL----------------------KPDVEVHGLIGAAENMPDGNAYRPDDVIKAKNGKYIEIDNTDAEGRVTLADVLSYASE-----------------------L---KPDK---------------IIDMATLTGACMVALGEYTAGLFTN----APDFAEEIKKTA---------------KRTGERVWELPMDDERLRKK-IKNTVADV--LN-TG--GRYGG-----------AITAAMFLEEFV---------------GE-GIKWVHLDIAGP--AW-SKEEYGYYTK-GG--TGFGVRTCLEYIMKVSSNV-  34
  35 --------------------------------------------------------------------------FLDQENKILYAGVKEDDVHLLRESACLAVRTLKKLAFKSVKVGVYTCGAHSKDNVLLENLKALFLGLKLGLYE----------YDTFKSNKKE--------SVLKEAVVALELHKPCEKTCTNSLETSAKEALKYAEIMTES-----------------------------------------LNIVKDLVNTPPMIATPVYMAEVAQKVAKEN------HLEIHVHDEKFLEEKKMNAFLAVNKASLGV--NPPRLIHLVYKPK------------KAKKK----IA---------------------------LVGKGLTYDCGGLSLK--PADYMVTMKADKGGGSAVIGLLNALAKL------------------G---VE-AEVHGIIGATENMIGPAAYKPDDILISKEGKSIEVRNTDAEGRLVLADCLSYAQD-----------------------L---SPDV---------------IVDFATLTGACVVGLGEFTSAIMGH----NEELKNLFETSG---------------LESGELLAKLPFNRHLKKLI--ESKIADV--CNISS--SRYGG-----------AITAGLFLNEFIRDEF--------------KDKWLHIDIAGPAYVEKEWDVNSF----GA--SGAGVRACTAFVEEF-----  35
  36 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MEYTGD-------PRS-KF---R----TG---------------------------LVGKGITYDSGGYSIK--SAPSMVSMHSDMGGAATVIGTMMAIARS------------------K---AK-VNVVGVVAACENLISGHAYKTGDVISSMAGKTIEVENTDAEGRLTLADAVYFATS-----------------------EL--KVDR---------------VIDLATLTGAVLVALGEEYTGVLTN----NKEFLEEVKVSA---------------KNAGEKIWELPNDPAYKKLF-E-SKVADL--KN-TG--GRYGG-----------SITAGQFVECFV-DG---------------DTPWIHMDIAGT--AY-LSKANGYLPE-RA--TGVHVKTLYQLL--------  36
  37 --------------------MKFNIAKKGGVVAQLVFEEKIEGGYLNHLKEKELFSGKAEDVYYTLDSNLKAQLFIGLGKEEKIDLEVLRKTFFKAAS----------ELLKNKVEEVELNIPKLNNLCNYKTAEAIAEGMLHATYK----------YDKFKS------DRKEQTEITVNYNPEKGKE------------DRAEKGINEAVKLMEA-----------------------------------------VFLTRDLVNQPANVIYPETLAKIAKEKLEAK----G--VKVTVHGKKEIEALKMEAFLNVARAST----KEPKLIVMEYYNN-------PGS-NE---K----IA---------------------------LVGKGLTYDSGGYAIK--PATSMVDMFTDMGGSGTVIGAMHALADL------------------K---AK-VNVVAVVASCENMISGDGYRNGDIIGSMSGKTIEIINTDAEGRLTLADAVYYATN-----------------------NL--GATK---------------LIDLATLTGACVSALGEQVSGAVTN----NDEFFSELVKAN---------------ERAGEIVWRMPTIEYYKKMN-E-SKVADL--KN-SG--GKLGG-----------MMTAGLFVGSFLAKE---------------DIPWIHIDIAGT--AY-ITEKFGYLKE-NA--TGTLVKSLYYMLSKEA----  37
  38 ---------------------------------------------------------------SNLGPNTENVILLGLGKEEENSLENIRRAYLSLGK----------SLKANNVKSCNIEIKKFDGLCYKLVAQAMIEGIVNVTYS----------FDNFLK---------EKKPCFDCEVFFDVLE-DKK--------DHVENGIKEIKAIMEA-----------------------------------------VFMCRDLVNRPANDIYPETLANFAKEELEKV----G--IEVEVLEKKQIESLKMDAFLAVAQGSD----LPPKFIIMKHLPN---------KDEK---P----IV---------------------------LVGKGLTYDSGGYAIK--PATGMVTMKTDMGGSASVISTMYAVGKM------------------N---VQ-RNVIALVASCENMINGHAYRNGDIISSMKGSTIEVVNTDAEGRLTLADAIYYGAS-----------------------KL--NPEC---------------IVDVATLTGACIHALGSRVIGAVSN----NDEVFAKIKESA---------------DYMGEYLWRFPVFEEHRQSV-K-GKVGDL--LNSTG--AGSGG-----------AITAGVFLEHFV--E---------------NTPWVHLDIAGP--SF-SSSAWGTNPE-GA--SGTPVKTLYNFVKK------  38
  39 ---------------------------------------------------------------------------------------------------KKNKFTAKASEKISMTLVNKKKVIDFIIVGLGENKKLDAKNIRQYLFDGLKNITGKVFVSFDDKDLDNMDVIAEVVEHINYKFDKYFSKKKEEFLEVSYLTDKKVPKLIEGYELAKI-----------------------------------------SNIVKDLVNEQAEVLNPKELADRAVKLGKEF------GFEVEILDEKKAQKLGMTAYLAVARAAH----HRPYVIVMRYKGD-----------AKSKYT----YG---------------------------LVGKGLTYDTGGLSLK--PTESMLTMRCDMGGAATMIGAMCSIAKM------------------K---LK-KNVTCVVAACENSIGPNAYRPGDILTAMNGKTIEVTNTDAEGRLTLADALTYIVR-----------------------KE--KVNE---------------VIDAATLTGAVMVALGEDVTGVFTN----DDKMAKKVIEAS---------------ENWNEYFWQMPMFDIFKKNL--KSPYADM--QN-TG--VRWGG-----------STNAAKFLEEFI----------------D-DTKWVHLDIAGT--AW-ASGANPYYSQKGA--TGQVFRTVY-----------  39
  40 ------------------------------------------------------------------DSYDKYVLAATSEKVVLPDYLDKESKKIAETIIKKNKFTAKASEKISMTLVNKKKVIEFIIIGLGEKKKLDAKNTRQYLFDGLKNIIGKVLFSFDNKDLDNIDILAEVVEHINYKFDKYFSKKKEEFLEVSYLTDKKVPKLIEGYELAKI-----------------------------------------SNIVKDLVNEQAEVLNPKELADRATKLGKKF------GFDVEILDEKKAQKLGMNAYLSVARAAH----HRPYVIVMRYKGN-----------AKSKYT----FG---------------------------LVGKGLTYDTGGLSLK--PTDSMLTMRCDMGGAATMIGAMCSVAKM------------------K---LK-KNVTCVVAACENSIGPNAYRPGDILTAMNGKTIEVTNTDAEGRLTLADALTYIVR-----------------------KE--KVNE---------------VIDAATLTGAIMVALGEDVTGVFTN----DEKMARKVIDAS---------------ENWNEYFWQMPMFDLYKKNL--KSSYADM--QN-TG--VRWGG-----------STNAAKFLEEFI----------------D-DTKWVHLDIAGT--AW-ASGANPYYSQKGA--TGQVFRTVYSYIKDNKN---  40
  41 --------------------------------------------------------------------------------------------------IKKNKFTAKSSEKISMTLVIKKKVIDFIIIGLGEKKKLNAKNTRQYLFDGLKNITGKVFLSFADKDLDDIDIIAEVVEHINYKFDKYLTKKREEFLEVSYLTDKKVPKLIEGYELAKI-----------------------------------------SNIVKDLVNEQAEVLNPKELANRATKLGKEF------GFDVEILDEKKAQKLGMNAYLGVARAAH----HRPNVIVMRYKGD-----------AKSKYT----YG---------------------------LVGKGLTYDTGGLSLK--PTDSMLTMRCDMGGAATMIGTMCAVAKM------------------K---IK-KNVTCVVAACENSIGPNAYRPGDILTAMNGKTIEVTNTDAEGRLTLADALTYIVR-----------------------KE--KVNE---------------VIDAATLTGAVMVALGEDVTGVFTN----DDKMARKVIDAS---------------ENWNEYFWQMPMFDIYKKNL--KSPYADM--QN-TG--VRWGG-----------STNAAKFLEEFV----------------D-DTKWVHLDIAGT--AW-ASGANPYYSQKGA--TGQVFRTVY-----------  41
  42 -------------EAVIVALFEEEKVNSFVKELDKAFEGQLQVLLEEKELSAKKKTISKVHSLGKTNVKRYYFVGLGKKESYSTETLRASLSKTFKTL----------KTAKVQDAAILLDSFVTDKLDAIDVAHIAAEVSCLGTYD----------LQTYKT-------DK-KESVELENFTVITAE--DA--------KEIEAALTVGYVHGRA-----------------------------------------TNSARTLVNMPPNVLTATKLAEYAVELAEKY----D--MDYKVLEKEEMEELGMGALLAVNQGST----EPPKMIALIYKGK--------EEWTD---V----IG---------------------------FVGKGITYDTGGYSLK--PREGMVGMKGDMGGAAAVLGAMEIIGEL------------------R---PE-QNVVAVIPSTDNVVSGTAFKPDDVITSMSGKTIEVLNTDAEGRLALADGITYAKK-----------------------L---GANY---------------LVDIATLTGGVIVALGNHTTGAMTN----DETLFENVLEAS---------------METDEPIWQLPIFERDKERV-RNSKFADL--NN-SP--GREGH-----------AVMAGTFLGEFA--E---------------ETPWVHLDIAGT--SD-TTSAHDLGPA-GA--TGAMVRTLATFVERF-----  42
  43 ---------------------EEEKTSSFVQELDKAFEGQLQVLLEEKELSTKKKAISKVHSLGKTNVKRYYFVGLGKKESYTTETLRAALGKAFKTL----------QAAKVQDAAILLDSFVTEKLDAIDVAHIAAEVQGLGTYE----------LQTYKS-------DK-KDRVELEKFTAITAE--DA--------QEIEAVLTVGYVHGRA-----------------------------------------TNSARTLVNMPPNVLTATKLAEYAVELAEKY----D--MDYKVLEKEEMEELGMGALLAVNQGSS----EPPKMIALIYKGK--------EEWTD---V----IG---------------------------FVGKGITYDTGGYSLK--PREGMVGMKGDMGGAAAVLGAMEIIGEL------------------R---PE-QNVIAVIPSTDNVVSGTAFKPDDVITSMSGKTIEVLNTDAEGRLALADGITYARK-----------------------L---GANY---------------LIDVATLTGGVIVALGNHTTGAMTN----NEELFEQVLEAS---------------METDESIWQLPIFDRDKERV-RNSKFADL--NN-SP--GREGH-----------AVMAGTFLGEFA--E---------------DTPWVHLDIAGT--SE-TSGAHDLGPA-GA--TGAMVRTLATFVERFS----  43
  44 ------------HGAVIVALFEEE-TSRFVQELDKAFEGQLQGLLDEKELSTKKKSISKVHSLGKTNVKRYYFVGLGKKEAYTTETLRASLSKTFKTL----------QAEKIQDAAILLDSFVTEKLDAIDVAHIAAEVYCLGTYR----------LQTYKT-------DK-KEHVELEKLVVITAE--DA--------KEIEAALTVGYVHGRA-----------------------------------------TNSARTLVNMPPNMLTATKLAEYAVELAEKY----D--MDYKVLEKEEMEELGMGALLAVNQGST----EPPKMIALIYKGK--------EEWKD---V----IG---------------------------LIGKGITYDTGGYSLK--PRDGMVGMKGDMGGAAAVLGAMEIIGEL------------------R---PE-QNVIAIIPSTDNVVSGTAFKPDDVITSMSGKTIEVLNTDAEGRLALADGITYAKK-----------------------L---GANY---------------LVDVATLTGGVIVALGNHTTGAMTN----NETLFEQVLEAS---------------METDERIWQLPIFERDKERV-RNSKFADL--NN-SP--GRDGH-----------AVMAGTFLGEFA--E---------------DTPWVHLDIAGT--SD-TTSTHDLGPA-GA--TGVMVRTLATLVERFGEE--  44
  45 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------S-QPDYQLESLIVYTAA--EA--------AEIEASLFVGSVYGKA-----------------------------------------TNSARTLVNTPGNLLTASDLADYAVKLANRY----D--FDYEVLEKEDMERLGMGALLAVNQGSK----QPPKLIVLKYQGK--------DEWED---V----IA---------------------------LVGKGVTFDTGGYCLK--PRDSMVDMKTDMAGAAAVLGAMEAIGEL------------------R---PE-QNVLAVIPATDNMISGEAFKPDDVITSLSGKTIEVKNTDAEGRLILADAVTYAKQ-----------------------H---GASY---------------IIDVATLTGGVIVALGTDKTGAMTN----NEELFEQLLEAS---------------METGEFIWRLPITENDRERV-RSSKIADL--NN-SP--GREGH-----------AIMGGAFIGEFA--E---------------DTPWVHLDIAGT--AA-TKKDGDLGPA-GA--TGVMVRTLTAFVERFE----  45
  46 --------------------------------------------------SVKRNQVSKVFPPLASGMKRIYFIGLGREADYTFEDAKECFARAFQTI----------HKDRKEEVSVLLDTFITDKVPAADAAHALAESCLLATYE----------VQDYKH-------KSNEPEKQMKSVYALTEG--DS--------QEVQAGLRVGRAFGQA-----------------------------------------ANSARMLVNMPGNMLTATDLASYAVELAAKY----D--FECEILEKDDMEELGMGGILAVNQGSS----EPPKMIVLKYQAK--------EAWED---V----IG---------------------------FVGKGITFDTGGYSIK--TKDGIVGMKSDMGGAAAVLGAMEAIGEL------------------R---PE-QNVLAVIPSTDNMISGAAMKPDDVIVSLSGKTIEILNTDAEGRLVLADGITYAKQ-----------------------H---GASV---------------LVDAATLTGGVVVALGTETTGAMTN----DQAFYQQVAEAA---------------EECGEAIWQLPITEKDKKRV-KNSQMADL--NN-SP--GREGH-----------AIMAGTFIGEFA--E---------------HTPWVHLDIAGT--AT-SKKATCFGPA-GA--TGVMARTLATLAER------  46
  47 -------------ETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLKEGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKECFAHIFQAI----------HKDRKQETAVLLDTFISEDVPPADAAHALAESCLLASYE----------VQDYKH-------KSNEPDKQIEAVYVVTDE--DT--------QEVQAGLRVGQAYGQG-----------------------------------------TNSARTLVNMPGNMLTATDLASYAEELAAKY----D--FECEILEKSEMEELGMGGILAVNQGST----EPPKMIVLKYQGK--------KEWED---V----VG---------------------------LVGKGITFDTGGYSIK--TKSGIVGMKSDMGGAAAVLGAMETIGEL------------------R---PE-QNVLCVIPSTDNMISGGAMKPDDVIVSLSGKTIEILNTDAEGRLVLADGITYAKQ-----------------------H---GASV---------------LVDVATLTGGVVVALGTETTGAMTN----DQSFYQQVADAA---------------QECGEAIWQLPITEKDKKRV-KSSQMADL--SN-SP--GREGH-----------AIMAGTFLGEFA--E---------------STPWVHLDIAGT--AT-ANKATCFGPA-GA--TGVMARTLATLAERF-----  47
  48 -------------------------------------------------------------------------------------------------SSLDHLRMAAFRLAKKASKRQIPVVSIMLADAAPEQFKSILLGLHYADYK----------FDAYKSKQKDSFQVTFELVAGEHT-------------------AEFKKIADVVAIENKA-----------------------------------------IVLAKNLINTSSSDLTPAEFVENANTIAKYT-----PGLSIKVRNMKQLEKEGFMGHVTVGKGSS----HEPYMITLSYDGS-KSSKKAAKNARTSADH----LV---------------------------FVGKGLTFDTGGLCLK--PPKSMPEMISDMSGAATVLAAIQAIATL------------------E---LP-IKVSAVCCLAENAIGNKSVLPGDIFTAKNGKTVMVDNTDAEGRLVLSDGLAEAGL-----------------------I---GATH---------------IVDLATLTGAMVRALGYAVAGFFSN----DDDLALKVINCG---------------EACCEKFWSMPLEEEYADAL--KDHFADL--KN-T---GSDAG-----------AIAAALFLQEFV---------------PE-NTAWTHWDIAGTAFVNKTWKYTDF----GA--TGFGVQTLIELARRM-----  48
  49 -----------------------------------VVDEDYKLVYQNALSNFSGKKGETAFLFGNDHTKEQKIVLLGLGKSEEVSGTTVLEAYAQATTVLRKAKCKIVNI--------LLPTISQLRFSLEEFLTNLAAGVLSLNYN----------YPTYHKVDTSLPFLEKVTVMGIVS-------------------KVGDKIFRKEESLFEG-----------------------------------------VYLTRDLVNTNADEVTPEKLAAVAKGLAGEF-----ASLDVKILDRKAILKEKMGLLAAVAKGAA----VEPRFIVLDYQGK-----------PKSKDR----TV---------------------------LIGKGVTFDSGGLDLK--PGKAMITMKEDMAGAATVLGIFSALASL------------------E---LP-INVTGIIPATENAIGSAAYKMGDVYVGMTGLSVEIGSTDAEGRLILADAISYALK-----------------------YC--NPTR---------------IIDFATLTGAMVVSLGESVAGFFAN----NDVLARDLAEAS---------------SETGEALWRMPLVEKYDQAL-H-SDIADM--KN-IG--SNRAG-----------SITAALFLQRFLEDN---------------PVAWAHLDIAGT--AYHEKEELPYPKY--A--TGFGVRCLIHYMEK------  49
  50 --------------------------------------------------------------------------------------------------NKASPVTV-----------------------------SAMEG------------------------------------------------------------AFEKDEWHVGSVLAQS-----------------------------------------QNYARHFMETPANYMTPTIFSNNAVEIFKGI-----PNVTVTVRNSDFMEEKKMGSFLSVSRGSE----QPPKLLEVHYNGG----------VA-GTKP----LA---------------------------FVGKGVTFDSGGISLK--PPTDMALMKGDMGGAACVLGATWGIAKL------------------G---VP-INLCTVIPLTENMPSGRATKPGDVVIAMNGKTIEVDNTDAEGRLILADAIYYAST-----------------------TF--KPHS---------------LVELSTLTGAMVVALGFPFAGVFSS----SDDLWKKLEAAG---------------EKSGDPFWRMPLSEKYKKQI--SSHVADL--KN-VG--GRTGG-----------SCTAAIFLKEFV-PTIPTAEGSDEPA-KL-ALDYAHVDIAGV--ME-QSGASGYLAK-GM--TGRPTRSLIAY---------  50
  51 --------------------------------------------------------------------------------------------------------------------------------------------------------------------PSPFDPNLKEPIPPKLQFSP----------------IEASKEWDRGVIYAES-----------------------------------------QNLARTLMEYPANMMTPTLFTERVKQEFAGI-----PNVEIIVRDEAWAAEKGMNVFLSVTRGTS----EPAKFLEIHYKGA----------ADKNAQP----LA---------------------------FVGKGITFDTGGISLK--PGAGMKLMRGDMGGAATVVSAALAIAKL------------------Q---LP-INLVVTTPLTENMPGPSATKPGDIIYAMNGKSVEVDNTDAEGRLVLSDAIYYTST-----------------------EY--KPHT---------------LIDVATLTGAMVIALGEVYSGVFAS----SDELWQQLYEAG---------------QIEHDRMWRMPLDDEFGPQI-HSSN-ADL--QN-TG--GRPAG-----------SATAALFLKPFV-NGLEPKEGEP-------TIKWAHLDIAGS--ME-ATRPSPYQDK-GM--TGRPVRALVEFTRRLANSA-  51
  52 ------------------------------------------------------------------------------------------------------ATAL------GIQALQKQGAKYTGVDVSIDV-QGAAEGAVLSQFS----------FEKLK--KNKKEEKEECVVEPYLPEQD----------------DEASKRWEVGQIYGAS-----------------------------------------QNIARMLMTSPSNLMTPKLFAEEVAYLLAGL-----ENIDIKVYGEDWVTRQKMNAFLSVAQGST----EPLRFLEIHYKGA----------KDKDEKP----YG---------------------------LVGKGITFDSGGISLK--PSANMALMKGDMGGAATVAGALYGISKM------------------K---LP-VNIVAVIPLCENMPSGNAIKPGDVIKAMNGSSIEILNTDAEGRLILADALHYVSS-----------------------KY--QPKS---------------IIDLATLTGAMDVALGQVFAGVFTN----RDELWEQLKKAG---------------AAVSDPFWRMPLHKDYMRGM-KESLVADL--SN-IG--GRSGG-----------SCSAAGFLQGFV-DE---------------KIPWAHIDIAGV--ME-CSATEGYHIK-GM--S-------------------  52
  53 -----------------------------------------------------------------------------------------------------------------TDALQ---------------------------------------------------------VEPFKANQD----------------------WEKGQIMGAS-----------------------------------------QNVARMLMTSPSNLMTPKLFAEEVAYLLAGL-----ENVEVIVRDEEWAAKQNMNAFLSVAKGSC----EPLRFLEIHYKGG----------KEGD-RP----HG---------------------------LVGKGITFDSGGISLK--PSNNMALMKGDMGGAATVAGALYGISKL------------------K---LP-VNVVAVTPLCENMPSSHATKPGDVIKAMNGKSIEILDTDAEGRLVLADALHYVSS-----------------------KY--SPAS---------------LIDLATLTGAMDVALGDVYAGVFTN----SDEMWQRLEAAG---------------RATHDPFWRMPLDDGYLKEM-QESLVADL--NN-LGK-GRSGG-----------ACSAAAFLREFI-TE---------------NVDWAHIDIAGV--MD-SQSTDGYHIK-GM--SGRPTRSLIEYIQKLS----  53
  54 -RGAIIGCYKSNNESYKFT-------------ENGSNINHFTNSKLKELLHCTSFKPDLGKTRTFLGLHKDYECITITGLDEEDPKENPNEEVNQKKENIRVAVGA------AALELKK-LEVKSIDVDSCGDASASAEGINLSLYS----------FNKFKSEKKD---------QPTFKMFDADNNN-----------KALFEDWHYGLKVSNS-----------------------------------------QNFARELMETPSNYKYPLLFANMVSERFLHT------SVKVHVRDLKWAADKNMNCFLSVGQGST----NPPVFLEMHYKGS-------------DQHP----IV---------------------------LVGKGITFDSGGISIK--PSKDMALMRGDMGGAACVIATLDAVSKL------------------K---LP-VNLVVLVPLAENMPSGNATKPGDVFKAMNGKTVEVDNTDAEGRLVLADALCYANE-----------------------F---HPTH---------------IIDVATLTGAMAVALGSGATGTFST----SYHLWSQLHKAG---------------MKTGDRMWRMPIYKCYTEQM-KCSKTADL--RN-TQK-SAGAG-----------SCTAAAFLK-------------------------------------------------------------------------  54
  55 -KGLIVGLYENEELTPLGQQLNE---------KT--------NGHLLKSVKLSDTKGKVGDSLVLYDVTPEVPRVAIVGLGKK----EQTPSVYEKNENTRRAVGS------GVKALKSKNASNFTIDSSIGCSKHTAEGAYLSNFK----------FDYKT--SGK-PNTTNESIEVTISNES----------------TESKNAFNEGKIFAES-----------------------------------------QNFARTLMEMPANLLTPTIFVETVKKQFKHL-ID-SGKVEMIVRDEQWAKDQKMGMFLGVAQGSE----EPLKFLELHYKGA----------SADGKDS----IV---------------------------YVGKGITFDSGGISIK--PSAGMGLMKGDMGGAASAVSSMFGVASL------------------G---LK-VNLITLTPLCENMPSGKATKPGDVHIAMNGKTVEIDNTDAEGRLILGDALHYAHT------------------------F--KPST---------------ILDMATLTGAIDVALGQHYAGVFAG----TDGLWDELNECG---------------NVSGDRMWRMPLLPEYRKQL-D-SKIADI--VN-SA--GRSGG-----------ACSAAMFLKDFV-TI---------------DR-WAHLDIAGV--MS-SSEDGPYIKK-GM--TGKPVRALIEFAKKHQQ---  55
  56 --------------------------------------------------------------------------------------------------------------------------------------------------------------------SGKTANSTNESIQVQLS-PS----------------PSSEECFKEGKILAES-----------------------------------------QNFARVLMETPANLLTPTNFVQHVSSQMKEL-ID-SGKVEMIVREEQWVKDQKMGMFWGVAKGSD----EPLKFLELHYRGA----------SADGKDS----IV---------------------------YVGKGITFDSGGISIK--PSANMGLMKGDMGGAATAVSAMFGVASL------------------G---LK-VNLITITPLCENMPSGKATKPGDILTAANGKTVEVDNTDAEGRLILGDALHYACS------------------------F--KPTH---------------IIDIATLTGAIDVALGQHYAGCFTT----TDSLWDQLNECG---------------NISGERLWRMPLIPEYRKQM-ETSKVADL--IN-SA--GRSGG-----------ACCAAGFLKEFI-TA---------------DQSWSHLDIAGV--MS-SSEDGPYIRK-GM--TGKPTRTLIEF---------  56
  57 ------------------------------------------------------------KVHV-----------------------------------------------------------------------------------------------------KT---------RP-----------HG---------SVDAAAWQKGVLYGDG-----------------------------------------QNLARQLMEAPANHVTPTVFANTIEQKLSLF-AD-RVIVHK--RPQSWIEGEQMGAFLSVSKGSE----EPPVFLELHYKGS----------SDSAQPP----LV---------------------------LVGKGITFDSGGISLK--PSSGMDAMRADMGGAATVCSAIVTAAAL------------------K---IP-INIIGLAPLCENMPSGKANKPGDVVRAKNGKTIQIDNTDAEGRLILADALCYAHS-----------------------F---KPRA---------------IINAATLTGAMDVALGSAATGVFTN----SDWLWERLHKAS---------------VVTGDRVWRMPLFQHYTKQV-TDSALADL--NN-VGKYSRSGG-----------ACTAAAFLKEFV-SA---------------NH-WAHLDIAGV--MT-NKDEVPYLRK-GM--SGRPTRTLVEF---------  57
  58 ----------------------A---------AGDAFDSRV-SGRLRELLAVCGPPLKKGKARVFHGLHQDFPSVVVVGLGKKNAGVNDQENWNEGKENIRAAVAV------GCRQIQD-LEIPCVEVDPCGDAQAAAEGAVLGLHE----------YNELK--QKK---------KPVVTPQ-----LHG---------SAGSEAWQKGVIYAEG-----------------------------------------QNLARYLMEAPANYITPIKFAEYIEQKLGNF-GS-NVKVHI--RPESWIAAQQMGAFLSVAKGSA----EPPIFLEIHYLGG----------ANANDSP----LV---------------------------FVGKGVTFDSGGISLK--PSSGMDAMRADMGGAATVCSAIVTAAAL------------------N---LP-INIIGLAPLCENMPSGKANKPGDVVTAKNGKTIQVDNTDAEGRLLLADALCYAHN-----------------------F---NARA---------------IVNAATLTGAMDVALGSAATGVFTN----SSWLWNHLYEAS---------------IVTGDRVWRMPLFEHYTKQV-TDCPLADL--SN-IGKYSRAGG-----------ACTAAAFLKEFV-TA---------------PH-WAHLDIAGV--MA-NKDEVPYLRK-GM--AGRPTRTLVEFAARLSQDSQ  58
  59 -KGLILGVFTNE-NEEGPSQFTN---------AADTFDKHV-SGKLRELLAISGPSLKKGKTRIFHGLHQDFSSIVVVGLGKKAAGVNPYENWDEDKENIRAAIAA------GCRQIQD-LEVPSVEVDPCGDAQAAAEGALLGLFE----------YDELK--QKK---------KPPVDVQ-----LHG---------SDGTEAWKKGLIYAKG-----------------------------------------QNLARYLMEAPANHMTPTRFATIVEEKLKSC-SN-KVTVHI--RNKSWIEAQEMGSFLSVAKGSD----EPPVLLEVHYKGS----------SDANEPP----LV---------------------------FVGKGITFDSGGISIK--PSSNMDAMRADMGGAATICSAIITAAEL------------------K---LP-LNMIGLTPLCENMPSGKANKPGDVVKAKNGKTIQVDNTDAEGRLVLADALCYAHS-----------------------F---KPRA---------------IVDAATLTGAMDVALGSGATGVFTN----SHQLWNHLYEA--------------------------------------------------------------------------------------------------------------------------------------------------------  59
  60 TKGLVLGIYNKE-KEDDVPQFTS---------AGENFDKLV-SGKLREVLNISGPPLKAGKTRTFYGLHEDFPSVVVVGLGRKTAGIDEQENWHEGKENIRAAVAG------GCRQIQD-LEISSVEVDPCGDAQAAAEGAVLGLYE----------YDDLK--QKK---------KVVVSAK-----LHGS--------SGDQEAWQKGVLFASG-----------------------------------------QNLARHLMETPANEMTPTRFAEIIEKNLKSA-SS-KTEVHV--RPKSWIEEQEMGSFLSVAKGSD----EPPVFLEIHYRGS----------PNAGEAP----LV---------------------------FVGKGITFDSGGISIK--ASANMDLMRADMGGAATICSAIVSAAKL------------------N---LP-INIVGLAPLCENMPSGKANKPGDVVKARNGKTIQIDNTDAEGRLILADALCYAHT-----------------------F---NPKV---------------IINAATLTGAMDIALGSGATGVFTN----SSWLWNRLFEAS---------------IETGDRVWRMPLFEHYTRQV-VDCQLADV--NN-IGKY-RSAG-----------ACTAAAFLKEFV-TH---------------PK-WAHLDIAGV--MT-NKDEVPYLRK-GM--TGRPTRTLIEFLLHFSQDSA  60
  61 TKGLVLGIYNKE-KEDDVPQFTS---------AGENFDKLV-SGKLREVLNISGPPLKAGKTRTFYGLHEDFPSVVVVGLGRKTAGIDEQENWHEGKENIRAAVAGHYRCEVGCRQIQD-LEISSVEVDPCGDAQAAAEGAVLGLYE----------YDDLK--QKK---------KVVVSAK-----LHG---------SGDQEAWQKGVLFASG-----------------------------------------QNLARHLMETPANEMTPTRFAEIIEKNLKSA-SS-KTEVHV--RPKSWIEEQEMGSFLSVAKGSD----EPPVFLEIHYRGS----------PNAGEAP----LV---------------------------FVGKGITFDSGGISIK--ASANMDLMRADMGGAATICSAIVSAAKL------------------N---LP-INIVGLAPLCENMPSGKANKPGDVVKARNGKTIQIDNTDAEGRLILADALCYAHT-----------------------F---NPKV---------------IINAATLTGAMDIALGSGATGVFTN----SSWLWNRLFEAS---------------IETGDRVWRMPLFEHYTRQV-VDCQLADV--NN-IGKY-RSAG-----------ACTAAAFLKEFV-TH---------------PK-WAHLDIAGV--MT-NKDEVPYLRK-GM--TGRPTRTLIEFLLHFSQDSA  61
  62 TKGLVLGIYSKE-KEDDVPQFTS---------AGENFDKLL-AGKLRETLNISGPPLKAGKTRTFYGLHQDFPSVVLVGLGKKAAGIDEQENWHEGKENIRAAVAA------GCRQIQD-LELSSVEVDPCGDAQAAAEGAVLGLYE----------YDDLK--QKK---------KMAVSAK-----LYG---------SGDQEAWQKGVLFASG-----------------------------------------QNLARQLMETPANEMTPTRFAEIIEKNLKSA-SS-KTEVHI--RPKSWIEEQAMGSFLSVAKGSD----EPPVFLEIHYKGS----------PNANEPP----LV---------------------------FVGKGITFDSGGISIK--ASANMDLMRADMGGAATICSAIVSAAKL------------------N---LP-INIIGLAPLCENMPSGKANKPGDVVRAKNGKTIQVDNTDAEGRLILADALCYAHT-----------------------F---NPKV---------------ILNAATLTGAMDVALGSGATGVFTN----SSWLWNKLFEAS---------------IETGDRVWRMPLFEHYTRQV-VDCQLADV--NN-IGKY-RSAG-----------ACTAAAFLKEFV-TH---------------PK-WAHLDIAGV--MT-NKDEVPYLRK-GM--TGRPTRTLIEFLLRFSQDNA  62
  63 TKGLVLGIYTKD-KEDDVPQFTS---------AGENFNKLV-SGKLREILNISGPPLKAGKTRTFYGLHEDFPSVVVVGLGKKAAGVDDQENWHEGKENIRVAVAA------GCRQVQD-LELSSVEVDPCGDAQAAAEGAVLGLYE----------YDDLK--QKK---------KPVVSAQ-----LHG---------GGDQEAWQKGVLFASG-----------------------------------------QNLARHLMETPANEMTPTRFAKIIEKNLRSA-NS-KTEVYI--RPKSWIEEQEMGSFLSVAKGSD----EPPVFLEIHYRGS----------PNASEAP----LV---------------------------FVGKGITFDSGGISIK--AAANMDLMRADMGGAATICSAIVSAAKL------------------N---LP-INIVGLAPLCENMPSGKANKPGDVVKAKNGKTIQVDNTDAEGRLILADALCYAHT-----------------------F---NPKI---------------IINAATLTGAMDVALGSGATGVFTN----SSWLWNKLFEAS---------------IETGDRVWRMPLFEHYTRQV-VDCQLADV--NN-IGKY-RSAG-----------ACTAAAFLKEFV-TH---------------PK-WAHLDIAGV--MT-NKDEVPYLRK-GM--TGRPTRTLIEFLLQFSENNA  63
  64 TKGLVLGIYSKE-KEEDEPQFTS---------AGENFNKLV-SGKLREILNISGPPLKAGKTRTFYGLHEDFPSVVVVGLGKKTAGIDEQENWHEGKENIRAAVAA------GCRQIQD-LEIPSVEVDPCGDAQAAAEGAVLGLYE----------YDDLK--QKR---------KVVVSAK-----LHG---------SEDQEAWQRGVLFASG-----------------------------------------QNLARRLMETPANEMTPTKFAEIVEENLKSA-SI-KTDVFI--RPKSWIEEQEMGSFLSVAKGSE----EPPVFLEIHYKGS----------PNASEPP----LV---------------------------FVGKGITFDSGGISIK--AAANMDLMRADMGGAATICSAIVSAAKL------------------D---LP-INIVGLAPLCENMPSGKANKPGDVVRARNGKTIQVDNTDAEGRLILADALCYAHT-----------------------F---NPKV---------------IINAATLTGAMDIALGSGATGVFTN----SSWLWNKLFEAS---------------IETGDRVWRMPLFEHYTRQV-IDCQLADV--NN-IGKY-RSAG-----------ACTAAAFLKEFV-TH---------------PK-WAHLDIAGV--MT-NKDEVPYLRK-GM--AGRPTRTLIEFLFRFSQDSA  64
  65 --GLVLGVYAKE-KEDVVPQFTS---------AGENFDKLV-CGKLREMLNISGPPLKAGKTRTFYGLHEDFPSVVLVGLGKKAAGVDDLENWHEGKENIRAAVAA------GCRQVQD-LELCSVEVDPCGDAQAAAEGAVLGLYE----------YDDLK--QKK---------KVVVSAK-----LHG---------SGDQEAWQKGFLFASG-----------------------------------------QNLARHLMEAPANEMTPTKFAKIIEKNLTSA-SS-KTEVHI--RPKSWIEEQEMGSFLSVAKGSD----EPPVFLEIHYRGS----------PDASEPP----LV---------------------------FVGKGITFDSGGISIK--PSANMDLMRADMGGAATICSAIVSAAKL------------------G---LP-INIVGLAPLCENMPSGKASKPGDVVRARNGKTIQVDNTDAEGRLILADALCYAHT-----------------------F---NPQV---------------IINAATLTGAMDIALGSGAAGVFTN----SSWLWNKLFEAS---------------IETGDRVWRMPLFDHYTRQV-VDCQLADV--NN-IGKY-RSAG-----------ACTAAAFLKEFV-TH---------------PK-WAHLDIAGV--MT-NKDEIPYLRK-GM--TGRPTRTLIEFLLRFSQDKA  65
  66 -------------------------------------------GKLREMLNISGPPLKAGKTRTFYGLHQDFPSVVVVGLGKRSAGVDDQENWHEGKENIRAAVAA------GCRQVQD-LELPSVEVDPCGDAQAAAEGAVLGLYE----------YDDLK--QKK---------KVAVSAK-----LHG---------SGDLEAWEKGVLFASG-----------------------------------------QNLARHLMESPANEMTPTRFAEIIEKNLKSA-SS-KTKVHI--RPKSWIEEQEMGSFLSVAKGSE----EPPVFLEIHYMGS----------PNATEAP----LV---------------------------FVGKGITFDSGGISIK--ASANMDLMRADMGGAATICSAIVSAAKL------------------N---LP-INIIGLAPLCENMPSGKANKPGDVVRARNGKTIQVDNTDAEGRLILADALCYAHT-----------------------F---NPKV---------------IINAATLTGAMDVALGSGATGVFTN----SSWLWNKLFEAS---------------VETGDRVWRMPLFEHYTRQV-IDCQLADV--NN-LGKY-RSAG-----------ACTAAAFLREFV-TH---------------TK-WAHLDIAGV--MT-NKDEIPYLRK-GM--SGRPTRTLIEFLLRFSKDSS  66
  67 --------------------------------------------------------------------------------------------------------------------------------DPCRDAQAAEEGAVLGLYE----------YDDLK--QKK---------KMAMSVK-----LYG---------TGDQEAWQKGVLFASG-----------------------------------------QNLA--MMETPASEMMPTRFAEIIEKNLKSR-XX-XTEFHI--RPRSWIEEQAMGSFLSVAKGSD----EPSVFLEIHYIGS----------PNADKPP----LV----------------------------VGKGITFDSGGISIK--ASANMDLMRADMGGATTICSAIVSAANL------------------S---LP-INIIGLAPL-XNMPSGKANKLGMVVRARNRKTIQVGNTDAEGRLILADALCYVHT-----------------------F---NPKV---------------ILNATTLTGVIDVALGSGATGVFTN----SSWLWNKLFEAS---------------IETGDRVWRMPLFKHCTRQV-VDCQLADV--NN-IGKY-RSAG-----------ACTSAAFLKEFV-TH---------------PK-WAHLDIAGV--MT-NKDEVPYLWK-GM--TGRPTRTLIEFLLRFSQDNA  67
  68 -RGLVLGVYEKG-EG---VRLTP---------GADLYNQQT-GGKLEEYIRLAGPTIKKGKSRVFYGLDKTYNAVAVVGLGAQGVGVNELEGLHEGKENLRAAAAS------GVRQLRDILGTSTIEIDGCSDAEAAAEGAALGLFV----------YEDLKAEDKR---------KKPVQTE-----LLKD--------SGSPQGWSKGRLLADG-----------------------------------------QNFARQLMEMPASHLTPTTFASITGERFGSI-GN--IQFEA--RDRAWAESMKMRAFLSVANGSE----EPPVFVEVKYSGN----------PDSSEKP----LV---------------------------FVGKGITFDSGGISLK--PPAGMDQMRADMGGAATVSGAIAGIASL------------------K---LP-INVVGLIPLCENMPSGKATRPGDVVTAMNGKTIQVDNTDAEGRLILADALCYAHS-----------------------F---NPRA---------------VIDLATLTGAIDVALGSAATGVFSN----SRVLWNLLHDAG---------------VGTGDRLWRMPLFNHYTSQV-THSQLADL--NN-VGKHGRQAG-----------ACTAAAFLRQFV-QC---------------PH-WAHMDIAGV--MA-NKDEVPYLNK-GM--AGRPVRTLVEFTAKLA----  68
  69 -KGIVLGVYENSTKEESNAILTP---------AAESFNKRT-DGRLAELLNISGPKMKKGKSKVFYGLDKEYPVIAVVSLGKQSAGIDELEEVNESKENIRAASAL------GARQLRD-AGMKQIELDPCTDAQAVAEGATLGLFT----------FDELKEESKR---------KPKVNLS-----LHG-------------------------------------------------------------------NRNRNLISL--------IFCNMFNF-----------------RTKDWIENQKMNAFLSVSKGSS----QPPVFLEMKYMGG----------VH-DSKP----LV---------------------------LVGKGVTFDCGGISIK--PSAQMDLMRGDMGGAAVVTASMAAIATL------------------Q---LP-INVVTLVPLCENMVNGEATRPGDVVTAMNGKTIQVDNTDAEGRLLLADALHYGCS-----------------------VH--KPEV---------------IINVATLTGAIQVALGSAVSAVFTN----SNNLWMNLHKAG---------------IDTGDRLWRMPLLQHYTKQI-SDSQLADV--NN-IGKSARDGG-----------ACTAAAFLREFV-TC---------------QN-WAHLDVAGV--ML-NKDEVPYLGN-GM--TGRPTRTLVEYVSNLSKKT-  69
  70 -KGLVLGVYAPE-NEGGNGVLTP---------ATQNFQGQVKDGSLANLLEVSGLDHKKGKSRVFYGINESFPSIAVVSLGKKSAGFNELEEVDEKRENIRAAVAS------GVKQLQD-AGVNVIHVDPCGDPEAAAEGAGLVTWA----------YDALK--EKK---------SPKVELQCFTEGADDT--------SSVQSLWNRGSILAEG-----------------------------------------QNFSRLLMEAPANVITPTGFTELAKEYLSNL-AN--VTVHV--RDREWAEKMKMNSFLSVTNGSW----EPCKFLEIIYNGG-----------KPGDAP----FA---------------------------IVGKGVTFDSGGISLK--PPASMDEMRADMGGAACTLGSIFTAAKL------------------E---LP-VNVHGFMPLCENMPGHKATKPGDVVTAMNGKTIQVDNTDAEGRLILADALCYAQT-----------------------F---KPSG---------------IIDMATLTGAMMVALGSSASGVFSS----STELWDIIHKAG---------------HRSGDRVWRMPLFRHYTRQV-TETALADL--NN-IGSGGRVGG-----------ACTAAAFLREFV-EH---------------DK-WMHIDIAGV--MT-NKKEVAYLGA-GM--SA--TRTIVEF---------  70
  71 ----------------------------------------------------------------------------------------------SRKPAVRISCAT----------------------------------------R----------YSQDK--------------------------------------NSMEKEWRKGAILAEG-----------------------------------------QNLSRRLMEMPANLLTPTKFAEIVKEQL----AD-KCEVLV--RDKDWAESMKMGSFLSVARGSV----EPPVFLEIEYKGR------------QSDSP----LA---------------------------LVGKGVTFDTGGISIK--PSQGMDAMRGDMGGAACVAGSLLSVSKL------------------Q---LP-VHVKAFIPLCENMPSGSATKPGDVVTAMNGKTIQVDNTDAEGRLILADALCYSEQ-----------------------F---NPSL---------------ILDMATLTGAIDVALGAGAAGVFTN----SENMWNKLQKAS---------------VRSGDRVWRMPLFNHYTKKI-TECQLADL--NN-IGGS-RSGG-----------ACTAAAFLKEFV-NN---------------KN-WLHLDIAGV--MS-NSGDVAYLGK-GM--SGRPTRTVIEFINLMSKET-  71
  72 -----------------------------------------------------------------------------------------------------------------------------------------------------------------K--QTP---------LPAVSF------AEDA--------SG-KADWDRGVIIAEA-----------------------------------------QNFARVLMETPANHMTPTIFADTVKQRLG-A-AN--VEVVV--HDEAWAKEKKMGSFLSVTNGSN----EPARFLELTYRGS-----------Q-DEQC----VA---------------------------LVGKGITFDSGGISLK--PSANMDQMRADMGGAANVVSTILALAQL------------------K---AP-VHVKGFVPLCENMPSGTATKPGDVVYAMNGKSICVDNTDAEGRLILADALCYAST-----------------------F---NPKF---------------ILDIATLTGAIKVALGDCVSGVFSS----NNKLWETIHEAG---------------SQTGDRVWRMPLFKHYSDQM-CDHNGYDL--NN-LGK-GKGGG-----------SCTAAAFLREFV-PK---------------GTPWLHVDIAGV--MG-DCSDQSYTGSKGM--SGRPMRTLVEFVTKA-----  72
  73 ----------------------------------------------------------------------------------------------------------------GVKALQE-VGIEIVSVDPCSDAECAAESASLTRWQ----------FQDLKNAAKR---------KPEVDLV-----LHGSDEYGLARKSLTEAQWERGLTKAAG-----------------------------------------QNLARWLMEMPANHMTPTIFARHAVDLLGRAGGD-GISIKVEAHDEAWASNQGMNSFLAVAQGSS----EPPVFLEITYNNL----------PS-KEKP----IV---------------------------IVGKGITFDTGGISIK--PSANMDKMRGDMGGAACTLATILTAANL------------------R---LP-LHLKGLIPLAENMPGGKAIKPGDVVKAMNGKTIQIDNTDAEGRLILADALAYAQQ-----------------------TY--QPNL---------------VLDIATLTGAINVALGSSAAGVFTN----SNALWHLVHQSS---------------FTTGDRVWRMPLWKHFQSAL--ESQLADL--NN-VGKTG-AGG-----------SCSAAAFLKEFT-DA---------------PH-WMHLDIAGVGGVV-DGSDVPYLAK-GM--TGRPTRTLIEVLSRISQ---  73
  74 ---IILGLHTPKEKGSDSNSTSKISVKEIKGTESFNFYNKKWNNDLTDLVSI-GNPLKAGQARTFYGKKDEFSAVTVVGIAESDPEVKSSELIDDEKENMRLAVAA------GIKSYKD-SGFSSLHVDAAVSPLGAAEGAFLASWS----------Y------KEKERNKFPSTISPLQ--------------------EQDEQEWNVGKVYADC-----------------------------------------QNFARFLMESPANLMTPTLFAENVSKAFEDAKKDTKGSIEVFVRDRDWIEKENMGAFLSVSNGSD----EPPKFVEIHYKSE-----------NFNGKP----LV---------------------------LVGKGVTFDCGGISIK--PSQAMDEMRADMGGAATVTSAILGACKL------------------N---AP-GHIIGLIPLCENMVNGKATKPGDVVTARNGTQIQVDNTDAEGRLLLADALLYGQD-----------------------F---KPTA---------------ILNAATLTGAIVVALGTAVTGVYSN----NELLWNQLQNAG---------------QSTGDRMWRMPLLKHYSSQV-KPSQLADI--NN-VGTGGRGGG-----------SCTAAAFLHHFV-DQ---------------GVKWAHLDIAGV--MSTNGSDLPYLCK-GM--AGRPTRTLLEFI--------  74
  75 -RGMVVGCYEGE-DG---AELTE---------AGKTLDAKY-NNKITRILKISGQQVKDGDSRLFYDISEDLTHLALVGLGKRGPE-EKQEDMLMSRHNVRCAAAA------GASLLKK-AKVKEIHLEGLSDPEAAAEGTHLALFT----------YDDMK--GKKPTNEEPTNEKPSVLLW-----DGSS--------EGEREQWGRGCVLAEG-----------------------------------------QNFARWLMETPSNHMTPTDFVDAVSRKLGQC-EN-KDKIEISPRPYSWIKEKKMGSFLSVAQGSD----EDPWFLEIKYNGA----------TSPDTNP----LV---------------------------LVGKGITFDSGGISIK--PAAGMPEMKADMGGAACVTGTTLAVAML------------------G---LP-INIVSLMPLCENMPSGKAVKPGDVVTAMNGKTIEVDNTDAEGRLILADALCYAHS-----------------------F---NPTG---------------IIDMATLTGAVGVALGSGAAGTYTT----SESMWERFHEAS---------------RTTGDRLWRMPLYNLYSKQM--KSRIADI--NN-LGTPSRSAG-----------SCTAAAFLKAFV-EC---------------DE-WCHLDIAGV--MSGGTADLPYLSK-GM--SGRPTRTIIQYI--------  75
  76 ------------------PRIPLATTKADSLILAVRHDKQVFSEDYRQVVDQYFETSPKKNDIRLFWNTQGFVRLAIVQLEE-----------NVSEKSVRSAAAE------AAKILKS-NGAKSIAVDGMGFPKDAALGAALATYDFSLRRDHLSVYQDEKVVEKENLFTSPAPERLTFQLLSNTSEKKTA--------TAEENAFKVGLIEAAA-----------------------------------------QNLARSLMECPANYMTSLQFCHFAQELFQNS-----SKVKVFVHDEKWIDEQKMNGLLTVNAGSD----IPPRFLEVQYIGK---------EKSKDDGW----LG---------------------------LVGKGVTFDSGGISIK--PSQNMKEMRADMGGAAVMLSSIYALEQL------------------S---IP-VNAVFVTPLTENLPSGSAAKPGDVIFMRNGLSVEIDNTDAEGRLILADAVHYVSS-----------------------QY--KTKA---------------VIEASTLTGAMLVALGNVFTGAFVQ----GEELWKNLETAS---------------HDAGDLFWRMPFHEAYLKQL-TSSSNADL--CN-VSRAG--GG-----------CCTAAAFIKCFL-AQK--------------DLSFAHLDIAGV--M--DKQLNSWDCD-GM--SGRPVRTIIEVARKY-----  76
  77 ---------------------------------------------------------------------QESTKVRIILYSPSKEGVDIKSEKKDSSHQAFLNRMGAKGNSGESYVLPEENGKITVFVGIGKEDENVFLVKNNAKKAGALAYKAVSQFKNLEIFLESEFMGKEVASGVTLASYKYQFLNKEKGEPKKVAINTQFPSVKKAIMIGNA-----------------------------------------QNFARFLGDTPANLMNPTLFTEYAAKYLHGK-----KNVTFEVFGKEFMKSKSMNLLLSVSQGSV----QEPKLFVAKYRGK--------GGDGVD-------IA---------------------------LVGKGVCFDSGGISLK--PSARMSLMKGDMLGAASVLSVFGLAADM------------------E---IK-INIDLVIPLVENLPSGTATKPGDVYIGMNGKSVEIDNTDAEGRLILADALVYAQE--------------------------GHPTY---------------IFDVATLTGAMAVALGDAFIGYFTS----DDKLSEIIYQSG---------------IDASDPTWRMPLSQLYLPTM--KSDVADL--KN-TGE-GRYGG-----------SASAAIFLNEFVGK----------------EYKWVHFDIAGV----MNSNNSKGIYGDGM--TGCSVSALIETIEKLSTIV-  77
  78 ---------------------------------------------------------------------------------------FYLTDHADGGVIVKFFKDRESVKSYANVDEDFFKRDNAIFVKKDRDYLIVYVKDEWKAYFLAGRYIKNSPFKEFIIDLREIESKDKAIIGILSTSYIFDRYKSEKQEKIIKFICDDKEKVKEYITLMEA-----------------------------------------QYLARDLANEPPNVLNPETYEKKIIEIFKGL------PVNIKVLHYDDLIREGLNLLVYVGKGSI----YKPRLVILEYNLK--------------DNP----IV---------------------------LVGKAITFDTGGYSLK--PTDYMYNMHGDMSGSAAVIGALYAIAKN----------------------KKDIPIVALIPIAENVISGESYKVNDIIKAYNGKTVEVTNTDAEGRLTLADAIAYSAK-----------------------Y---NPKA---------------IIEVSTLTGGQIIALGHEIAAAMGE----KD-LVNKAIEAG---------------KEVYELVWELPLYEGYRELL--KSAVADI--KN---ANGREAH-----------AIQGGLFLKEFSPIE-----------------KFLHLDIAGP--AI-ANRAIPSAYK-GL--TGFGVRLLYKLVQKL-----  78
  79 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YEFDHYKSSKKALFKTNLNLISESLIELDFIHEGISIGQS-----------------------------------------INLARDFSNMPPNVLTPQTFAEDIVNHFKNT------KVKVEVKDYDTLVSEGFGLLQAVGKGSK----HKPRLVTITYNGK-----------DKDEAP----IA---------------------------LVGKGITYDSGGYSIK--TKNGMATMKFDMCGAANVVGIIEAASRL------------------Q---LP-VNIVGVLACAENMINEASMKPDDVFTALSGETVEVMNTDAEGRLVLADAVYYANQ-----------------------Y---QPSV---------------IMDFATLTGAAIVALGDDKAAAFES---NSKVILNDILQIS---------------SKVDEMVFELPITATERASI-KHSDIADL--VNHTNGQGK--------------ALFAASFVTHFSG-----------------QTPHIHFDIAGP----ATTNKASYNGPKGP--TGFMIPTIVQWL--------  79
  80 -------------------------------------------------------------------------------------------------------------------------------------------------------------------EASALGWALAAYRFDRYRKNESPSA---------TLFPGSASIAESARKKAQA-----------------------------------------VARVRDLINTPACDMMPKDLADTTLEIARRH------GADLQITAGDELLEKGYPAIHAVGRAS---A-HAPLLIDLRWGEE--------NA-----PL----VV---------------------------LVGKGVCFDSGGLDIK--NAAGMRLMKKDMGGAAHAIALAELIMQS------------------G---LD-LRLRVLIPAVENAISGDAFRPGDILSTRKGLTIEVDNTDAEGRVVLSDALHEGAS-----------------------E---KPDL---------------MIDFATLTGAARIALGYELPAMFTD----DDEIAQGIEAAG---------------RKVHDPVWRLPLHAPYRGL--IRSRIADI--AN-A-TSKAPGGG-------AGGAITAALFLQAFV---------------PD-GIPWVHFDIMAW--MNRAR--PGRPEGGEA--MSLRAVFEFL----------  80
  81 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDLINTPAEDMGPSELAQAVKHVAKEF------EAKVKIIESKD-LETEFPAIYAVGRAG---S-RPPLLIDLKWGDI--------KA-----PK----VT---------------------------LVGKGVCFDSGGLDIK--TPGGMLLMKKDMGGAAHALGLARMIMLQ------------------Q---LP-VRLRLLIPAVENAIGSRSYRPGDVVQTRARKTIEITNTDAEGRVVLADALAEAVK-----------------------E---DPDL---------------LIDFSTLTGAARIALGPNLPALFAN----QDSLAQALIDAS---------------LKTDDPLWRLPLFQPYRNY--LKSEVADL--TN-S-SQNR-----------MAGAITAALFLQHFV---------------SD-QIPWAHFDIFAW--NLEDL--PGRPIGGEA--MALRAVFHYLEQQY------  81
  82 -----------------------------------------------------------------------------------------------------------------------------------------------------------------DARLAALAFALGCYRFARYRKADGPDV---------RLVPPDGVDAVEISRMADA-----------------------------------------AMLARDLINTPSNDMGPEELAAAAQELASEF------GASFACTIGED-LRTDFPLIHAVGMAS---D-RAPRLIDIGWGDP--------AH-----PK----VT---------------------------LVGKGVCFDTGGLDLK--PSSGMLIMKKDMGGAANVLALARMVMDA------------------K---LK-VRLRVLIPAVENAVAGNAFRPLDIFTSRKGITVEIGNTDAEGRLVLADALALADE-----------------------E---KPDL---------------LIDLGTLTGAARVALGPDLPPFYTN----DETLAADVARCA---------------VKENDPLWRMPLWPAYDAW--LDSKTATI--TN-A-----PSGG-------FAGSITCALFLQRFV---------------EQ-AKSWLHVDIYGW--TPSAK--PARPEGGEC--QAARAIYTLL----------  82
  83 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EISRMADA-----------------------------------------AMLARDLINTPSNDMGPEELAAAAQELASEF------GASFACTIGED-LRTDFPLIHAVGMAS---D-RAPRLIDIGWGDP--------AH-----PK----VT---------------------------LVGKGVCFDTGGLDLK--PSSGMLIMKKDMGGAANVLALARMVMDA------------------K---LR-VRLRVLIPAVENAVAGNAFRPLDIFTSRKGITVEIGNTDAEGRLVLADALALADE-----------------------E---KPDL---------------LIDLGTLTGAARVALGPDLPPFYTN----DETLAADVARCA---------------VKENDPLWRMPLWPAYDAW--LDSKTATI--TN-A-----PSGG-------FAGSITCALFLQRFV---------------EQ-AKSWLHVDIYGW--TPSAK--PARPEGGEC--QAARAIYTL-----------  83
  84 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKDKEKEDRKV---------VLAWPAGADKGRVTAAAAS-----------------------------------------TFLVRDLITTPCEHMGPQQLEAVFASLAEEF------GGTTKVVRGDELLEGGV-TVHAVGRAAGV-G-REPRLLDLTWAPA--------GSDAESLPK----VT---------------------------LVGKGVCFDTGGLDIK--PAAGMLTMKKDMGGGAQVLGLARMIMSQ------------------G---LP-VRLRVMVPAVENAIDGGAFRPGDVLVSRSGKTSEIGNTDAEGRLVLADALVEASS-----------------------E---MPDL---------------LIDCATLTGAARVALGTDVPVVFCN----DEELAAKLHTLS---------------GSVSDQVWRLPLWEGYRSQ--LSSKIADL--KN-V-----GAGG-------YGGAITAALYLDEFVGEKAPPSTEEGEGRKKE-KLPWIHMDFMAF--NTN-----------------------------------  84
  85 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGCYKFDVYKSKKRKESEGEEKLGFEKLVWPSGCNEDYVLTAASA-----------------------------------------IFLTRDLISTPAEDMAPGDLESAARKLASMY------GGKVTAVVGDDLLRQNYPQIHAVGRATPP-GKHAPRLIDLRWGKE--------SD-----PK----VT---------------------------LVGKGITFDTGGLDIK--PASGMRQMKKDMGGSALVLGLAHMIMRL------------------K---LN-VRLRVLIAAAENNVDAVSFRPGDILVARNGMTTEIGNTDAEGRLVMADALVAACE-----------------------E---KPEL---------------LIDAATLTGAGRVALGTDVPAVFCN----NEELGSELCSLS---------------EKENDLVWRLPLFKGYAKS--LASRIADM--KN-V----AEGSG-------YGGAITAALYLQKFV---------------TA-GTDWVHMDFMAF--NT------------------------------------  85
  86 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDLITTPAEDLGPQHLAAEAEALAAAH------GAAFRVLQGDELLEHNYPAIHTVGRASHR-W-LPPLLATLEWSPP----GAATGAGGEALPV----LA---------------------------LVGKGVCFDTGGLDLK--PAASMKNMKKDMGGAALVLALAHCVMAA------------------R---LR-CRLRVLVPAVENAVAGNAFRPLDGSVDRYAVGVANGNTDAEGRLILADALADALGRNCRVNPNQPPPTATPTAPTANFQ---LPDL---------------LIDAATLTGAARVALGADLPAVFAN----DDDTWRALEAAA---------------AVTGDPVWRLPLHAPYRKS--LDSKVGRR--FG-C-CSGVWGVGCGMWGLKVGGCGTRG---------------------------SWLHIDTNAF--NVGVAVGPGRPEGGEA--QGLRALFAMLCARY------  86
  87 -------------------------------------------------------------------------------------------------------------------------------------------------------MTEAMKITLSTQPADARWGEKATYSINNDGITLHLNGADDLGLIQRAARKIDGLGIKHVQLSGEGWDADRCWAFWQGYKAPKGTRKVEWPDLDDAQRQELDNRLMIIDWVRDTINAPAEELGPSQLAQRAVDLISNV---ASDRVTYRITKGEDLREQGYMGLHTVGRGSE----RSPVLLALDYNPT---------GDKEAPVY----AC---------------------------LVGKGITFDSGGYSIK--QTAFMDSMKSDMGGAATVTGALAFAITR------------------G---LN-KRVKLFLCCADNLISGNAFKLGDIITYRNGKKVEVMNTDAEGRLVLADGLIDASA-----------------------Q---KPEM---------------IIDAATLTGAAKTALGNDYHALFSF----DDALAGRLLASA---------------SQENEPFWRLPLAEFHRSQL--PSNFAEL--NN-TGSAAYPAG-----------ASTAAGFLSHFVENY---------------QQGWLHIDCSAT-----YRKAPVEQWSAGA--TGLGVRTIANLLTA------  87
  88 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEG-----------------------------------------IQLAARLVDTPPNVLSTTAFVEEALAVARGL-PPSMCAVK--VIRGDELEAQGFGGLYGVGKAAV----EPPALVVLSYLPD--------GA---A-AG----AAGAAGAGAGGSAAQTAAAGGVGGRGSVCFVGKGIIYDTGGLSIK--TKTGMPGMKRDMGGAAAILGAFQAAVKAQMAAAAAAGSGSGGSGWVG---GR-RPLHALLCLAENSVAANATRPDDIHTLYSGRTVEINNTDAEGRLVLSDGVAYAAR-----------------------HL--GPSV---------------IIDMATLTGAQGVTTGRRHASVLSN----DEALEKMAVECG---------------RSSGDLVHPVVYCPEFFSEE-FRSTVADM--KN-S-VADRSNAQ----------VSCAGQFIANHMEAFVAGPA-------AG-GGRWLHCDMA------------------------------------------  88
  89 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ANA-----------------------------------------IQLATRLVDAPPNELHSDAFIAEARAVAE----RTNSKIS--VIQGEELREKGFGGIYGVGKAAT----HKPALVCLSHVPE--------GA---A-TD----AKGVA------------------------MVGKGIIFDTGGLSIK--TGGIMVGMKRDMGGAASLLAAFEAACLAKNTTDTT-------------------PLHVVLCIAENSVGPDSTRVDDVLVMYSGKTVEVNNTDAEGRLVLGDGVAYAVK-----------------------HL--NPKV---------------VVDMATLTGAQGISTGNRIGAVYTN----DEDLEAMAVKAG---------------KISGDLVHPMPYAPEFHRLE-FKSSIADM--KN-S-VKNRANAQ----------VSCAGQFIANHL-----GDF-------EH-TGKWLHVDMAY----------PVFTGDDE-----------------------  89
  90 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------------------------------------VRLAARIVDTPCNEMNTDSFLEEIKKVGKDL------GIVPTIFRNAELKEKGFGGIYGVGKAAV----HPPALAVLSHTPE--------GA---T-QT----IA---------------------------WVGKGIVYDTGGLSIK--GKTTMPGMKRDCGGAAAVLGAFKATIKQ------------------G---FK-DNLHAVFCLAENSVGPNATRPDDIHVLYSGKTVEVNNTDAEGRLVLADGVAYARK-----------------------DL--GADI---------------ILDMATLTGAQGIATGKYHAAVLTN----NEEWERACVKAG---------------RNCGDLVHPLVYCPELHFTE-FTSAVADM--KN-S-VADRDNSP----------SSCAGLFIASHI------GF-------DW-PGIWVHIDIA------------------------------------------  90
  91 ----------------------------------------------------------------------------------------------------------------------------MVCERSEVFASACALARAFPLFTHRSS----------------ASRRTEKKTVTVEFFLVGQN----NGPIE-------VETLKCLASATEG-----------------------------------------IRLAARIVDTPCNEMNTDNFLEEIKKVGKDL------GITPTVIRDEELKERGFGGIYGVGKAAL----HPPALAVLSHTPD--------GA---T-QT----IA---------------------------WVGKGIVYDTGGLSIK--GKTTMPGMKRDCGGAAAILGAFKATVKQ------------------G---FK-DNLHAVFCLAENAVGPRATRPDDIHVLYSGKTVEINNTDAEGRLILADGVAYACK-----------------------DL--GADI---------------ILDMATLTGAQGIATGKYHAAVLTN----NEEWEKACVKAG---------------RNCGDLVHPLVYCPELHFSE-FTSAVADM--KN-S-VADRDNTP----------SSCAGLFIASHI------GF-------DW-PGVWVHIDIAA----------PVH-AGERA--TGYGVALLLSLFGGASEDPL  91
  92 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------------------------------------VRLAARIVDTPCNEMNTDTFLEEIKKVGKDL------GITPTIIRDEELKTRGFGGIYGVGKAAV----HPPALAVLSHTPE--------GA---T-QT----IA---------------------------WVGKGIVYDTGGLSIK--GKTTMPGMKRDCGGAAAVLGAFRAAIKQ------------------G---FK-DNLHAVFCLAENSVGPNATRPDDIHLLYSGKTVEINNTDAEGRLVLADGVSYACK-----------------------DL--GADI---------------ILDIATLTGAQGIATGKYHAAVLTN----SAEWEAACVKAG---------------TRCGDLVHPLVYCPELHFSE-FTSAVADM--KN-S-VADRDNSP----------SSCAGLFIASHI------GF-------DW-PGVWVHLDIA------------------------------------------  92
  93 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------------------------------------VRLAARIVDTPCNEMNTDTFLEEIKKVGKDL------GITPTIIRDEELKTRGFGGIYGVGKAAV----HPPALAVLSHTPE--------GA---T-QT----IA---------------------------WVGKGIVYDTGGLSIK--GKTTMPGMKRDCGGAAAVLGAFRAAIKQ------------------G---FK-DNLHAVFCLAENSVGPNATRPDDIHLLYSGKTVEINNTDAEGRLVLADGVSYACK-----------------------DL--GADI---------------ILDIATLTGAQGIATGKYHAAVLTN----SAEWEAACVKAG---------------TRCGDLVHPLVYCPELHFSE-FTSAVADM--KN-S-VADRDNSP----------SSCAGLFIASHI------GF-------DW-PGVWVHLDIA------------------------------------------  93
  94 ----------------------------------------------------------------------------------------------------------------------------MVCEQPEVFASACALARAFPLFTHRSG----------------ASRRLEKKTVTVEFFLVGQD----NGPVE-------VSTLQCLANATDG-----------------------------------------VRLAARIVDTPCNEMNTDTFLEEINKVGKEL------GIIPTIIRDEELKTRGFGGIYGVGKAAL----HPPALAVLSHTPD--------GA---T-QT----IA---------------------------WVGKGIVYDTGGLSIK--GKTTMPGMKRDCGGAAAVLGAFRAAIKQ------------------G---FK-DNLHAVFCLAENSVGPNATRPDDIHLLYSGKTVEINNTDAEGRLVLADGVSYACK-----------------------DL--GADI---------------ILDMATLTGAQGIATGKYHAAVLTN----SAEWEAACVKAG---------------RKCGDLVHPLVYCPELHFSE-FTSAVADM--KN-S-VADRDNSP----------SSCAGLFIASHI------GF-------DW-PGVWVHLDIAA----------PVH-AGERA--TGFGVALLLALFGRASEDPL  94
  95 ----------------------------------------------------------------------------------------------------------------------------MVCERSDAFASACALARAFPLFTHRSG----------------ASRRTEKKTVTVEFFLVGQD----NGPVE-------VSTLQCLTSATEG-----------------------------------------VRLAARIVDTPCNEMNTDTFLEEIKKVGKEL------GIVPTVIRDEELKARGFGGIYGVGKAAI----HPPALAVLSHTPD--------GA---T-QT----IA---------------------------WVGKGIVYDTGGLSMK--GKTTMPGMKRDCGGAAAVLGAFRAAVKQ------------------G---FK-DTLHAVFCLAENSVGPNATRPDDIHLLYSGKTVEINNTDAEGRLVLADGVSYACK-----------------------DL--GADI---------------ILDVATLTGAQGIATGKYHAAVLTN----SAEWEAACVKAG---------------RQCGDLVHPLVYCPELHFSE-FTSAVADM--KN-S-VADRDNSP----------SSCAGLFIASHI------GF-------DW-PGVWVHLDIAA----------PVH-AGERA--TGFGVALLLALFGQASEDPL  95
  96 ----------------------------------------------------------------------------------------------------------------------------MVCERADAFASACALARAFPLFTHRSG----------------ASRRMEKKTVTVEFFLVGQD----NGPVE-------VSTLQCLANATEG-----------------------------------------VRLAARIVDTPCNEMNTDTFLEEIKKVGKDV------GITPTIIRDEELKTRGFGGIYGVGKAAV----HPPALAILSHTPD--------GA---T-QT----IA---------------------------WVGKGIVYDTGGLSIK--GKTSMPGMKRDCGGAAAILGAFRAAVKQ------------------G---FK-DNLHAVFCLAENSVGPNATRPDDIHLLYSGKTVEINNTDAEGRLVLADGVSYACK-----------------------DL--GADI---------------ILDMATLTGAQSIATGKYHAAVLTN----SAEWEAACVKAG---------------RKCGDLVHPLVYCPELHFSE-FTSAVADM--KN-S-VADRDNSP----------SSCAGLFIASHI------GF-------DW-PGVWVHVDIAA----------PVH-AGERA--TGFGVALLLALFGRASEDPL  96
  97 ----------------------------------------------------------------------------------------------------------------------------MVCEQTEVFASACALARAFPLFTHRSG----------------ASRRAEKRTVMVEFFLVGQD----NGPVE-------VSTLQCLTNATEG-----------------------------------------VRLAARIVDTPCNEMNTDIFLEEIIQVGKEL------GITPTIIRDEQLKTKGFGGIYGVGKAAL----HPPALAILSHTPD--------GA---T-QT----IA---------------------------WVGKGIVYDTGGLSIK--GKTTMPGMKRDCGGAAAVLGAFRAAIKQ------------------G---FK-DNLHAVFCLAENAVGPNATRPDDIHLLYSGKTVEINNTDAEGRLVLADGVSYACK-----------------------DL--GADI---------------IVDMATLTGAQGIATGKYHAAVLTN----SAEWEAACVKAG---------------RKCGDLVHPLVYCPELHFSE-FTSAVADM--KN-S-VADRDNSP----------SSCAGLFIASHI------GF-------DW-PGVWVHLDIAA----------PVH-AGERA--TGFGVALLLALFGRASEDPL  97
  98 ----------------------------------------------------------------------------------------------------------------------------MVCERTEVFASACAIARAFPLFTRRSA----------------SSRRTEKKHVTLEFITVGQD----NGPLE-------LSTLECLANAADG-----------------------------------------VRLAARIVDTPCSEMNTDDFLEEIKTVGNAL------GITPTIIRGEELKQKGFGGIYGVGKAAL----NPPALAVLSHTPS--------GA---T-QT----IA---------------------------WVGKGIVYDTGGLSIK--GKTTMPGMKRDCGGAAAILGAFKATIKQ------------------S---FK-DNLHAVFCLAENSVGPAATRPDDIHTLYSGKTVEINNTDAEGRLVLSDGVVYASK-----------------------DL--SADI---------------ILDMATLTGAQGISTGKHHAAVMTN----SEQWELACVRAG---------------RSSGDLAHPLVYCPELHFSE-FTSALADM--KN-S-VADRENAQ----------SSCAGLFIASHL------GF-------DW-PGVWVHVDIAS----------PVH-AGERA--TGFGVALLLSLFGQASEDPL  98
  99 ----------------------------------------------------------DRTFKEALSNLHPSPTDSCPLWLNNATVAALPSKASRHNTPSRAHALSKIVR--SSMAGCREECIVLVCEKSEVFASACAVSRVFPSFSRKSG-------------------SSQRRKIVVEFLLVDGG---KDNTIS-------EDDAKCLQAACNA-----------------------------------------VRLTAQIVDTPCNEMNTDDFLNEIQTVGSQV------GITPVIIRGEELKQRGFGGIYGVGKAAD----HPPALAILSHRPT--------GA---T-QT----VA---------------------------WVGKGIVYDTGGLSIK--GKTAMPGMKRDCGGAAAVLGAFCAAVQQ------------------G---FQ-DNLHAIFCLAENAVGPLATRPDDIHKLYSGRTVEINNTDAEGRLVLGDGVAYAAK-----------------------DL--QADI---------------IVDMATLTGAQGISVGKYHAAILTN----NKE----------------------------------------------------------------------------------------------------------------------------------------------------------------  99
 100 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAS-----------------------------------------IRLAQRIVDTPCNEMNTDDFITEIHQVQEKL-KSIGKNVKTTIIRGEELNKKGFGGIYGVGKAAI----NPPALAVLSYTPD--------NA---T-QT----IS---------------------------WVGKGIVYDTGGLSIK--GKTTMPGMKRDCGGAAAILGAFQAAVQQ------------------G---FQ-ENLHAVLCLAENSVGPIATRPDDIHVMYSGRSVEINNTDAEGRLVLADGVSYASK-----------------------DL--KSDI---------------IVDMATLTGAQGISTGKIHGAILTN----REEWELACVKAG---------------KNSGDLVFPLVYCPEIHFNE-FASAVADM--KN-S-VSDRGNAQ----------SSCAGLFIGAHI------GF-------DF-PGVWLHIDMA------------------------------------------ 100
 101 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LSARIVDTPCNEMNTDHFLEEIGIVAKEL------GIEPFIIRDKELERQGFGGIYGVGKAAP----NPPALVVLSHLPK--------GA---T-KT----IA---------------------------WVGKGIMYDTGGLSIK--GKTAMPGMKRDCGGASGILGAFRLAVLT------------------G---FK-ENLHAVFCLAENSVGPLSTRPDDIHTLYSGRTVEINNTDAEGRLVLADGVFYAHK-----------------------DL--KADV---------------ILDMATLTGGQSVATGKQHAAVLTN----NEHWENALVDAG---------------LVSGDLTFPIPFCPEFHFSE-FNSAVADM--KN-S-VADRSNAL----------SSCAGLFILAHL------GF-------DY-PGVWMHVDMA------------------------------------------ 101
 102 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ADS-----------------------------------------IQMAARIVDTPCNIMNTTQFVKEAEEVGLEL------GIKPTIISGEELNERGFGGIYGVGKAAV----HPPALVVLSHCPP--------DA---T-KT----IA---------------------------WCGKGIVYDTGGLSIK--GKTTMPGMKRDCGGAAAILASFRSAVKR------------------G---FK-QNLHAVLCLAENAVGPVATRPDDIHILYSGRSVEINNTDAEGRLVLGDGVAYASK-----------------------DL--KADI---------------ILDMATLTGAQGVSTGKYHAAVLTN----DEIWEAASVAAG---------------KASGDLAFPLVYCPELHFPE-FNSAVADM--KN-S-VADRSNAQ----------SSCAGLFIGSHL----MGAF-------NF-SGTWVHVDMA------------------------------------------ 102
 103 -----------------------KSDPAHKHVAILGQVSNLKRASWNDVRNHLEPKVSESVWKGAVASLNPAPTDTCALWMNGASVGAFSEKSSRHNMPSGAYHIPKLLR--SCLLGKGDKVLVVVCKEEEMFPCGCAIARSFSLFSMRTD----------------SGGATKPARNITVEFVVVGE----STCNM-------VDVAACLQDTADS-----------------------------------------IQMAARIVDTPCNIMNTTQFVKEAEEVGLEL------GIKPTIISGEELNERGFGGIYGVGKAAV----HPPALVVLSHCPP--------DA---T-KT----IA---------------------------WCGKGIVYDTGGLSIK--GKTTMPGMKRDCGGAAAILASFRSAVKR------------------G---FK-QNLHAVLCLAENAVGPVATRPDDIHILYSGRSVEINNTDAEGRLVLGDGVAYASK-----------------------DL--KADI---------------ILDMATLTGAQGVSTGKYHAAVLTN----DEIWEAASVAAG---------------KASGDLAFPLVYCPELHFPE-FNSAVADM--KN-S-VADRSNAQ----------SSCAGLFIGSHL----MGAF-------NF-SGTWVHVDMAS----------PVH-SGERA--TGYGVALLMVLFGELSSDK- 103
 104 ARTYSSARFKKMATDVKFNESLGCSDPQTHPVLIIGQLRHLNLLKFSHLETKLSPRVTEETFLNAVACLHPEPTDKVSLYLDVATVAALPLKASRHNTASRAHAITRLVK--NHVLNVSEESVVLVCERENLFASACAVVRAFPLYSRKTGNLLASSQPKLNLGCGDGNANSGRNVVNVEFVLINKDGCIESEPLT-------DDELNCLNETTRA-----------------------------------------IRMTARIVDMPCNEMNVDHFIQEVEDVGREL------CITPKVIRGEELLEQGFGGIYGVGKAAA----VPPALVVLSHEPK--------GA---Q-ET----IA---------------------------LVGKGIVYDTGGLSIK--AKTGMPGMKRDCGGAAAILGTFYAAVQC------------------G---FR-DNLHAVFCLAENSVGPNATRPDDIHTLYSGRTVEINNTDAEGRLVLADGVCYANK-----------------------DL--KANI---------------ILDMATLTGAQGVATGKYHGAILTN----SETWEAKSLQAG---------------RKSGDLLAPIIYCPELHFSE-FASAIADM--KN-S-VADRQNAQ----------SSCAGLFIAAHL------GF-------DY-PGIWMHVDMAT----------PVH-CGERA--TGYGVALLLTLFGGHTDSKL 104
 105 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NCDPLS-------GHEIQLLQNVSDS-----------------------------------------IRLAAKIVDMPCNIMHTDAFIDEVNKVGKEI------GILPTVIQGKELDEKGFGGLYGVGKAAI----HQPALVILSHTPA--------GA---T-KT----IA---------------------------WCGKGIVYDTGGLSIK--DKNNMPGMKRDCGGAAGILGAFRTAVKM------------------G---FK-ENLHAVFCLAENAVGPLATRPDDVHTLYSGLTVEINNTDAEGRLVLGDGVAYAKK-----------------------DL--KAEI---------------IIDMATLTGAQGIATGKYHAAILSN----NEEWENRCVKAG---------------KMSGDLVFPVPYCPELHFEE-FNSHVADM--KN-S-VKSRSNAQ----------VSCAGLFIGAHI------GF-------DF-SGVWVHIDMAA----------PVELQNERG--SGYGVALLLTLFGKYSNNDL 105
 106 ------------MALLKFHRTLQTTDPHTVPVLIVGQLRHLTELPFERISSKLEPRVERETFAKAVSCLHPAPTDTCSLYLDLARVAALPLKSSRHNTASRAHSITKLIQ--SNTTGVS-ESIVIVCEKQDLLASACAVARAFPLYSRKTS---------------KGANVDPPPTVHIEFVLVGGNSPT-DTEIT-------EEDVLVLANVTVG-----------------------------------------IRLTARIVDAPCNEMNVSGFLSEVEAIALEL------GLKSKIIRGEELQQKGFGGIYGVGKAAL----DPPALAVLSHEPK--------GA---T-ET----VA---------------------------WVGKGIVFDTGGLSIK--GKTAMPGMKRDCGGAAAILGGFYAAVKS------------------G---FR-QNLHAVFCLAENSVGPLATRPDDIHRLYSGCTVEINNTDAEGRLVLADGVVYADR-----------------------DL--KANV---------------ILDMATLTGAQGIATGKYHGAILTN----SDEWEEKAMEIG---------------RRTGDMLCPVPYCPELHFSE-FNSAVADM--KN-S-VMDRGNAQ----------VSCAGLFIGAHL------GF-------DY-GGSWMHVDMAA----------PVH-NGERA--TGYGVALLAGLFGEHSKAAI 106
 107 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------------------------------------IRLTQYIVDAPCSEMHTDGFLEQIKEVGAKL------GLTPFVIRGENLREKGFGGIYGVGQGAS----RPPALAVLSHCPP--------GA---T-KT----IA---------------------------WVGKGIVFDTGGTCLK--TRLSMLGMKRDCGGAAAILGGFYAAVKL------------------G---FS-ENLHAVFCLAENSIGPLATRPDDVHTLYSGKTVEINNTDAEGRLVLGDGVVYASK-----------------------DL--KADI---------------VVDMATLTGAQGIATGKYHGAILSN----DEGIEGHCSIAG---------------RASGDLAFPVPFSPELHFSE-FNSVLADM--KN-S-VQDRSNAQ----------VSCAGLFIFSHL------GF-------DF-PGTWLHIDMA------------------------------------------ 107
 108 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AHG-----------------------------------------IRLAAEIVDKPCSHMNTDDFVKEAEVVGREL------QITPFIVRGEELKEKGFGGIYNVGRAAE----HPPALIVLSHRPQ--------GA---T-KN----IA---------------------------WVGKGIVFDTGGLCIK--ARQGMCGMKRDCGGAAGILGAFYAAVKL------------------G---FT-ENLHAVFCVAENAVGPLATRTDDVYTHYSGRTVEVNNTDAEGRLVLADGVAYARK-----------------------DL--KADV---------------VVDMATLTGAQGIATGKYHGSIVTN----DENMELWCVKAG---------------QNSADLVHPMPYSPELHFRE-FNSAIADA--KN-S-VADRSNAQ----------VSCAGLYIASNL------GF-------DY-PGVWLHIDMAA----------PVYN--------------------------- 108
 109 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------KQTQRVVNVEFVITDSD----NASLT-------EEEVATLQVTAQS-----------------------------------------IRESARIVDMPCNEMNTMDFVKEIQRIGQSL------GITPLIIQGEELKQKGFGGIYGVGKAAA----NPPAFAVLSHTPP--------NA---S-QT----IA---------------------------WVGKGIVYDTGGLSIK--GKTAMPGMKRDCGGAAAILGAFYAAVKE------------------G---FQ-ENLHALFCLAENAVGPDATRPDDVHIMYSGRSVEINNTDAEGRLVLADGVSFAAK-----------------------DL--KADI---------------IVDMATLTGAQGISTGKYHAGLLTN----NEDWEVASTKAGDGKLSLPRRSECIRYLSSASLRKD----------S-Y------I--QI-A-SEDRGNAQ----------SSCAGLFIGSHI------GF-------DF-GGVWIHFDIA------------------------------------------ 109
 110 ---------------LQFSGANSTSDPANRSVLIVGQLPNLTKVPYDIVKTKLQPRVTEESYGMALGCLSPSPTDTVSLWFNNATLAALPMKASRHNAPSRCHILTKLVR--SCLTGSGNECIVVASEHAHVFPLGCAIARAFPLYSRKAG-----------------SRKQTQRIVNVEFVITDSD----NASLT-------EEEVATLQVTAQS-----------------------------------------IRESARIVDMPCNEMNTMDFVKEIQRIGQSL------GITPLIIQGEELKQKGFGGIYGVGKAAA----NPPAFAVLSHTPP--------NA---S-QT----IA---------------------------WVGKGIVYDTGGLSIK--GKTAMPGMKRDCGGAAAILGAFYAAVKE------------------G---FQ-ENLHALFCLAENAVGPDATRPDDVHIMYSGRSVEINNTDAEGRLVLADGVSFAAK-----------------------DL--KADI---------------IVDMATLTGAQGISTGKYHAGLLTN----NEDWEVASTKAG----------KAIR----GAFHKDFKF-NQFNFGH-YKKWVIDV--DK-S-FTDRGNAQ----------SSCAGLFIGSHI------GF-------DF-GGVWIHFDIAA----------PSY-SGERA--TGYGVALLLGLFGSATKSRL 110
 111 --------------RLVYSNGQHSRDPHDNPCLIIGQYNYLKALKYEDVAKKFGDRVDQKTFYEGIELC--TRCSTVNLWLNYVKMAVLPPAGSRHNSPCSPHFLPTLIH--RGLLHSENEDIVIICRKADAFALACAVARCYPTFNRKYR------------------GSVIDRTVTVEFCITDDR----TAVLT-------SEDIAVMDAAACG-----------------------------------------IRTACYIVDAPCNMMQTTHFVEEAKRIAKLL------KVKSLIIEGEDLKAGGFGGIYGVGQAAS----APPALVVLSHTPR--------NA---T-KT----FA---------------------------WVGKGIVYDTGGLCIK--TKTGMPGMKRDCGGAAAILGAFYAAVSQ------------------G---FS-QNLHAILCLAENAVGPKATRPDDIHTMYSGYTVEINNTDAEGRLVLSDGVHYALK-----------------------NL--KADV---------------ILDMATLTGAQAIATGLYHAAVLTN----QESWETAATAAG---------------RSSGDLVHPVPYAPELHFPE-FSSSVADM--LN-S-VLNRGNAQ----------VSCAGLFIGKHI------GW-------DY-KGAWIHVDMAA----------PAH-SGERA--TGYGVALLLVLFGFASHNPL 111
 112 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MARA-----------------------------------------IRLAARLVDTPTNYMHTDAMIDEAKQVAQ-L-DCKTGKVSMEVIRDRELQEKGFGGLWNVGKAAE----HGPALVVLTYTPS--------DMPKDA-QT----VC---------------------------WVGKGIVYDTGGLSIK--GKSDMPSMKRDMGGSAAVLASFSAATQI------------------G---CK-FKLVALLCLAENSVDSVSMRPDDIITMLSGKTVEVNNTDAEGRLVLADGVNYAAS-----------------------TF--NPDV---------------ILDMATLTGAQCIATGKKHAAVLCN----NTESEKKIVEAG---------------IVTGDLVYPVVYCPEFFMEQAFRSEVADM--KN-S-ADDRSNAL----------SSCAGHFIEAHL------PE-------SY-KGVWIHIDMA------------------------------------------ 112
 113 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVIRGPELRDRGYGGIWGVGKAAV----NQPALAILSYDPE--------GA---S-QT----VC---------------------------LVGKGVMYDTGGLSLK--ISGSMVGMKADMAGAAGLLGAFYGLVES------------------K---VN-KRIHLVLCLAENAIGPNALRNDDILRMYSGLCVEINNTDAEGRLLLADGVAHACK-----------------------HL--SPDI---------------LIDMATLTGAQLISTGKKHAALVCN----SEELENRAIMAG---------------KKSGDLCHPLPFCPEIFKDE-FKSKVADM--KN-S-VKDRSNAQ----------SSCAGIFIHQHL------PK-------DF-KGEWLHVDMAG----------------------------------------- 113
 114 ------------MAQILVRNGIQAVGEGLTSVVIVGKKSVLQAVSFEGRFQEVAQKFVGDSSSWTSMVSRINSSGRLPLHYELAHLIAVPDTASRGNTPTNSHALFRDMRSVSYPSDVQNVHVVLFAEYSDVLAHVAAIARTFCKFSMKTSATEARSL---------------------------------NVNIDVVCDQFTSQDAHFLTDLSES-----------------------------------------VRETARLIDTPANILTTDALVEEAVKVGHAV------GATVSVIRGEDLLTGGFGGIYHVGKAGP----TPPAFVVLSHEVA--------GS---T-ES----IA---------------------------LVGKGVVYDTGGLQIK--TKTGMPNMKRDMGGAAGMLETFSALVKN------------------G---FS-QTLHVCLCIVENNVSPIANKPDDIIQMLSGKTVEINNTDAEGRLILADGVFYAKE-----------------------IL--NATT---------------IFDMATLTGAQAWLSGRMHGAAMTN----DEELENAMVRAG---------------KASGDLVAPMLFAPDLFYAD-LKSPIADM--RN-SNLGKMEGPP----------SAVAGLFIGAHI------NF-------GE-GLRWVHLDIAA----------PAE-CGDRG--TGYGPALFSSLLGKYTNVPI 114
 115 ------------MTQVLVRNGIQAVGDGLTSLIIVGKKSVLKNVTFEGKFKEVAQKFVTDGDSWNSMISRIPASGRHPLHYELAHLITVPDASSRGNTPTNAHSIYKELKPINYPEDTKNVHFVLFAEYPDVLSHVAAIARTFCKFSMKTSGI--REL---------------------------------NVNIDVVCDKLTNEDAVFLTDLSES-----------------------------------------VRETARLIDTPANILTTDALVDEAVKVGNAT------GSKITVIRGEELLKAGFGGIYHVGKAGP----TPPAFVVLSHEVP--------GS---T-EH----IA---------------------------LVGKGVVYDTGGLQIK--TKTGMPNMKRDMGGAAGMLEAYSALVKH------------------G---FS-QTLHACLCIVENNVSPIANKPDDIIKMLSGKTVEINNTDAEGRLILADGVFYAKE-----------------------TL--KATT---------------IFDMATLTGAQAWLSGRLHGAAMTN----DEQLENEIIKAG---------------KASGDLVAPMLFAPDLFFGD-LKSSIADM--KN-SNLGKMDGPP----------SAVAGLFIGAHI------GF-------GE-GLRWLHLDIAA----------PAE-VGDRG--TGYGPALFSTLLGKYTSVPM 115
 116 -----------------------------VILGTHAQLREDALKELPFYCPAVAEAIQRVKKGETYAVLAEGVKNEANERFVRVLVGEVPSEASRTNCSARPDVVVSLLS--AALEEIKGPETKVDVFVCSTAALAIAVAAA----------------------------RSAKRNFTAKEGLAARGYCDNCVRLTVVFPTAPNPSPSELVVVATS-----------------------------------------TQLCQRLVDAPTNLLNTATFAEVAQSYAKEL------GCAVDVICGEELRERGYGGIYSVGKCAA----EAPRLVTLSYKPK--------DE---TRKK----VA---------------------------LVGKGIVYDSGGLSLK--PTNFMTGMKRDMGGAAAVFCGFLTAVRL------------------Q---MP-IELSCTLCLAENAIGPDAYRNDDILTLKSGKTVEVNNTDAEGRLVLGDGVFHATH-----------------------EISFKPDV---------------LVDMATLTGAQGIATGHRHAGIFVN----DEEEELSFLKAG---------------RVSGETCFPVLYCPEYHVTE-FRSPVADM--RN-S-VKQVNNAS----------VSCAGHFVANHL------SP-------DF-KGKHIHVDMAF----------PAF-ENDKA--TGFGPALLMEY--------- 116
 117 -------------------------------------------------------------------GKSVTVAALDGGLK-RVIFAPTGPLNRDYDDVRRFADAAENGIKRAIKAGCQSPVLVTVKND---------K------FKYASFVAALGAMQALYVPLEIREAKP-EKKN------KLLKLGL---W--SGESSPY--LIPTVDAFESG-----------------------------------------RSLVRDIQGSDPERMAPPRVADYVTANFA-N-----TNIKVEVVSDCDYIEKNYPCLGAVNRAAKVVPRHNARVIKLFYE-----------GSGPITDT----LF---------------------------LVGKGVTYDTGGADVK--AGGIMAGMHRDKGGASAVAGFFQILEKL------------------K---PAHLKVYGTMSMVRNSIGANGYVADEIITARSGKRVRVGNTDAEGRMAMADCLCEAKE---------------------------MAKN----EVNPH------LYTIATLTGHAIIAMGPGYSIAMDNGPAREIQNSLKLRDAG---------------DAVGDMFEISTIRREDYVFHTGKSEYEDILQCNNAPSSRTPRG-----------HQSPSAFMIMTS------GLDSHGLDSDH-PLKYTHLDIAG----------------------------------------- 117
 118 ----------------------------------------------------LKKPLEDLKQIDDSVGKSVTVAALDGGLK-RVIFAPTGPLNRDYDDVRRFADAAENGIKRAIKAGCQSPVLVTVKND---------K------FKYASFVAALGAMQALYVPLEIREAKP-EKKN------KLLKLGL---W--SGESSPY--LIPTVDAFESG-----------------------------------------RSLVRDIQGSDPERMAPPRVADYVTANFA-N-----TNIKVEVVSDCDYIEKNYPCLGAVNRAAKVVPRHNARVIKLFYE-----------GSGPITDT----LF---------------------------LVGKGVTYDTGGADVK--AGGVMAGMHRDKGGASAVAGFFQILEKL------------------K---PAHLKVYGTMSMVRNSIGANGYVADEIITARSGKRVRVGNTDAEGRMAMADCLCEAKE---------------------------MAKN----EVNPH------LYTIATLTGHAVIAMGPGYSIAMDNGPAREIQNSLKLRDAG---------------DAVGDMFEISTIRREDYVFHTGKSEYEDILQCNNAPSSRTPRG-----------HQSPSAFMIMTS------GLDSHGLDSDH-PLKYTHLDIAGS-----EGKFPG-----IP--TGAPITGLYSRY-------- 118
 119 ----------------------------------------------------IKDALLKLKSIDDSVGKDVAIGTIDGPMK-RVIFSPTGPLDRDYDDVRRFGDAAGKGVERALSAGCKKPLLVTIKDK---------R------YKQCSFASAMGALQKLYVPLEIREALP-EKKQ------KVEKFGL---W--SKENVEY--LVQMTSAFEKG-----------------------------------------KIVSRDIGASDPERMAPPKVAEYVLEAFR-D-----TCVKVTVESDLKVIEKNYPCLAAVNRCASVIDRHGARVVRLFYE-----------GEGPITNT----VF---------------------------LVGKGVTYDTGGADVK--AGGNMAGMHRDKCGAATVAGILKIFAEL------------------K---PKHLKVCGTMSMVRNSIGANCYVADEIITSRAGVRLRIGNTDAEGRMAMADCLCEAKE---------------------------EALA----AINPQ------LYTLATLTGHAILAVGPNYTLVMDNGPAKEANNSIMIQIKG---------------HVLGDPCEMSTIRREDYEFHTGKSEYEDVLQAGNKPSTQTPRG-----------HQGPAAFLIMAS------GLDKHGLDSNK-QLKYTHVDNAAA-----VFPFPG-----IP--EAKATTMLAARYI------- 119
 120 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EERVQQ--GIVLANAVEAG-----------------------------------------RIVTRDIGGSDPERMAAPNVAKYVEEVFK-G-----TCIKVSVKSDQDQLNKEYPLYGAVNRAASQVSRHQGRVIFLEYT-----------GEGNTEKT----LF---------------------------LVGKGVTYDTGGADIK--AGGVMAGMHRDKCGAAAVAGFFKILSEM------------------K---PKGLKVVGAMAMVRNSVGSNCYVADEIITSRAGVRVRVGNTDAEGRMAMADVLCHLKE---------------------------QALT----AVNPQ------LFTIATLTGHVIRAYGENYSAILDNGPARNMNNAQEIQAAG---------------DEWADPFEISTLRRDDYDFHRGKSEYEDVLQCNNAPSSATARG-----------HQTPAAFLIEAS------GLEKHGKDSDK-PLPYSHLDIAG----------------------------------------- 120
 121 ---------------------------------------------------LKAPLQDYSAVDCCIKDEVVVLRVPGLPGN-RLVCSCTGPVNRDYDDVRRFRDAAANGIKRALKAGLQRPLLVCPPNS---------S------YAKNTLVAVLGALHVLYVPLEVREHK--SSPH------KVATLGI---WVKNKEQGDG--IIELANALESG-----------------------------------------RFVYRDIGGSDPERMAAPRVAEYVQSVFK-D-----SPVKVTVVSNLNTLEKEYPCLAAVNRCANAVPRHQARVIKLQYC-----------GEGPIEQT----LM---------------------------LVGKGITYDTGGADIK--AGGIMAGMHGDKCGSAAVAGFFQILAKL------------------K---PKHLKVVGAMAMVRNSVGSDCYVADELVVSRAGRRIRVGNTDAEGRMVMVDLLCEMKE---------------------------QALQ----EVSPH------LFTIATLTGHAIRAMGPKYSIIMDNGAARRAGNDLEWQKAG---------------EVLGDLFEVSTIRREDYEFHKGKSEYEDILQANNLPSSATPRG-----------HQTPAAFLIMAS------GLDQHGVDSAK-PQPYSHIDIAGS-----SGPFPG-----VP--TGAPILAMAAKYLK------ 121
 122 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SG-----------------------------------------RIAGRDIGGSDPERMAAPRVEEYVRELFQ-G-----SSISVEVVSDVKTIEKEYPLFAAVNRCANDVDRHAGRVIYLRYK-----------GSGPIEKT----IY---------------------------LVGKGVTYDTGGCDIK--AGGVMAGMHRDKCGSAAVAAFMKVVDEL------------------K---PTNVEVVGAMAMVRNSVGSNAYVSDEIITSRAGIRVRVGNTDAEGRMAMADVLCKLKE---------------------------EAVK----AVNPQ------LMTIATLTGHAYLTVGEPYSIILDNGPAARQQVSQKVQEAG---------------SLLGDMFEISTIRKEDYAFVKGKSEYEDILQCNNLPSSRTPRG-----------HQAPAAFLIVTS------GLNKHGIDGAV-PLPYSHLDIAG----------------------------------------- 122
 123 -----------------------------------------------------------------------------------------------------------------VA-------------------------------------------------------------------------------------------------VESG-----------------------------------------RLVARDIGGSDPERMAPPKVEEYVKALFK-N-----SPVNVEVISDPETLAKDYPLHAAVDRCASHIDRHRGRILELEYK-----------GEGNIENT----LL---------------------------LVGKGVTYDTGGADIK--HGGTMAGMHRDKCGAAAVAGFFQVLSSL------------------K---PKNIKVIGAMSMVRNSVGADAYVSDEILTSRAGVRVRIGNTDAEGRMAMADPLCKMKD---------------------------LALG----EVNPH------IYTIATLTGHAVRAMGPYYSIVLDNGPAQKKKHAELLQKAG---------------ENVADPFEISRIRREDYTFHEGKSEYEDVLQSNNAPSTMTCRG-----------HQSPAAFLIMAS------GLDKHGCNSSN-PLCYSHLDIAG----------------------------------------- 123
 124 ----------------------------------------------------------------------------------RVVFSPTGPINRDYDDHRNFADAAGAGIKRAIAAGMTRPLLIVCPSP---------G------YPNSVLAAALGALQAAYVPLEIREDVP-EKGN------KLSSLTI---Y--SDGASNE--LKKFIDGIESG-----------------------------------------RLVARDIGGSDPERMAAPNVARYVENVFAGS-----SSVKLEVISDDAALMECYPLFSAVNRCAKLVDRHRGRVIKLEYV-----------GSGEITKT----LM---------------------------LVGKGVTYDTGGADIK--AGGVMAGMHRDKCGAAAVAGFFRTLDII------------------K---PAGLKVIGTMAMVRNSVGVESYVADEIITSRAGARIRIGNTDAEGRMAMGDCLCEMKE---------------------------KALK----EINPH------LMTIATLTGHAIRAMGPDYSIIMDNGPAKKTDHARNMQRAG---------------DLIADPFEISTIRREDYAFHKGKSEYEDVLQANNKPSTLTPRG-----------HQSPAAFLIMAS------GLDKHGQDSSS-PLAYSHIDIAGS-----SGPFPG-----VP--TGAPIAAMTALYM------- 124
 125 ------------------------TELCGSQWDGIVLVTDDPSKLDGSLEVLKEAIQTYKEVDSGADGLAVVIPLPSLPAK-RLIYACTGPVTRDIDDVRRFYDAAVKGVQRALKAGCKSPLLVCPAHP---------L------YVHARGVATLGALHALYVPLEIRQDVP-DRTT------KAQQLGV---WAVSEETANN--IAKRVEALESG-----------------------------------------RIVARDIGGSDPERMAAPRVVEYLQEKFK-D-----TAIKMRVTSDAAEFEENYPLLAAVNRCAKAVSRHHGRLIHLEYT-----------GEGEVDKT----LL---------------------------LVGKGITYDTGGADIK--AGGVMAGMHRDKCGAAAVAGFFQVLDAI------------------R---PKKLRVLGMLAMVRNSVGADSYVADELITSRAGVRVRVGNTDAEGRMVMTDPLCEMKE---------------------------RALK----ETNPE------LFTIATLTGHAIRAMGPNYSIIMDNGPARKLQTAQQMQQVG---------------HEFADPFEISTLRREDFDFVRGPSEYEDVLQCNNQPSSATPRG-----------HQFPAAFMMQSS------GLDKHGCDSAQ-PLPYSHMDIAGS-----SGPFPG-----VP--TGAPIIALAAKYIYPRL--- 125
 126 ------------------------------------------------------------------------------------IYSSTGPVNRDYDDVRRVTDAAKAAIVRAYKAGHKRPVLVLPKETP---------------FSNSFEAGVLGALSAAYVPLELREARP-NKAR------NIDELGV---FVRNGQE-EA--LVPFLKAIESG-----------------------------------------RLVSRDIGGSDPERMAPPNAARYVQEAFI-D-----TPVKVNVISDVDMIEKEYPLFAAVNRCSKTVPRHNGRIVYLEYT-----------GEGAIEET----LL---------------------------LVGKGVTMDTGGADLK--VNGVMRGMHRDKCGAATVAGFFQILSRL------------------R---PKNIKVMGGMALVRNSIGTDCYVCDEIITSRAGVRVRVVNTDAEGRMAMSDVLCRMKE---------------------------KAQN----EINPH------IMTIATLTGHAVMAVGGSYSCVLDNGPASRLHTAHKLQEAG---------------HQIGDPLEVSTLRREDYDFVGPDTIYEDVRQCNELPSSRTPRG-----------HQFPAAFMIRAS------GLDKFGIDADK-PIRYTHLDIAGS-----SGLYPQ----VNP--TGAPLPSLAQRYL------- 126
 127 ------------------------------------------------------IKGALQSRSKIDASFNSGTHILEVTNR-ALIYAPTGPLNRDYDDVRRITDAAKAGINRASKAESKRPLLILPSETP---------------FPHSFESGVLGALSAAYVPLELREAR---QTR------YIEELGV---FVRNENE-KS--LIPFLSAIESG-----------------------------------------RLVCRDIGGSDPERMAPPNAANYVQDVFK-D-----TPVKVQVISDVETIGKEYPLFAAVNRCSETVPRHNGRIVYLEYN-----------GEGTPDET----LL---------------------------LVGKGVTMDTGGADLK--VGGAMRGMNRDKCGAATVAGFFQILARF------------------R---PKNIRVLGGLALVRNSIGTDCYVCDEIITSRAGVRVRVVNTDAEGRMAMCDVLCRMKE-----------------------------------------------------------------LCVLDNGPAKKVQTACKLQCAG---------------DEVGDPLEISTLRREDYDFVGPESVYEDVRQCNDLPSSRTPRG-----------HQFPAAFMIRAS------GLDKFGIDAEN-PIRYTHFDIAGS-----AGLSPR----VIP--TAAPLPALAQRYL------- 127
 128 -------------------------------------------------------AISSHKKIDKSESDVVVLMCSGVPSS-RLIYCPTGPVTRDYDDVRSFQEAAVRAVKRALSAGCRRPLLVGLNHE---------R------FSLSARVTILGGLDALYTPLEIRESCP-DRAC------KADQVGI---LLPGLKDADP--EVKILRALTVG-----------------------------------------RTVYKDIGGSDPERTAPPAVADYVTEIFK-S-----TCIKVNVISDEAVLEQEYPLLAAVNRASKVVPRHHARLIFLEYV-----------GEGSIDST----LM---------------------------LVGKGVTYDTGGADLK--VGGCMAGMSRDKCGAAFVAGFFQTLSML------------------K---PKGIKVIGAMCMVRNSIGSDCYVSDEIITSRAGVRVRIGNTDAEGRMAMGDVLCHMKE---------------------------KAAN----EVNPQ------IFTIATLTGHVIRAYSEAYSAVVPNGPAKEKGIPELLSKSG---------------EKSGEPFEISTLRREDYALHAAKSEYADCIQANTKPSTMTNRG-----------HQTPAAFLAMAS------GIAQHGCDSSA-PLPYSHLDIAGS-----SGSFPQ-----PP--TGAPLVAMAHAYL------- 128
 129 -----------------------------------------------------------SEVDGLLLSEVSGVVTPNKEVK-LVVYSPTGPINRDYDDVRRYKDAAIAGVKRALKSKKKNLLLVVSNSEPGLTK-----------YKDALLVSVLGAFEALYVPLEVRESSP-ANAK------KVNKLGISSTKLQSEETGAP--FIRKATALEWG-----------------------------------------RIIARDIGGSDPERMCPLKVEEFVREVFK-N-----TSISINVVFGHDNLRADFPLFAAVDRCANMVERHRGRIIYLEYC-----------GEGEVENS----YF---------------------------FVGKGVTYDTGGADVK--AGGHMAGMHRDKCGAATIAGLFAVLNEL------------------Q---PKGIRVVARLAIVRNSIGAESYVADEIITSKAGCRVRVGNTDAEGRMAMTDSLYHCKE---------------------------EALN----SKNPH------LFTIATLTGHAIIAMGDKYTIALDNGAANMEGFARHIQELG---------------DCLADPFEVSMLRREDFQFASGRNEYEDALQCNNEPSSRTPRG-----------HQFPAAFMIKAS------GLDKHGIDSDH-PIKYTHLDIAGS-----SGPYPG-----IP--TGCPLPSLT----------- 129
 130 -----------------------VSDLSDKRFDVVIFINDDADEGCAKDAAVYEALKSFSKINPNLGSELSIVPFPAHPSG-RLIYSPTGALNTDTADIRNVYDAACAGVKRALSMGCHAPLLYLGSLRSASFGFEWMQ------RKHLLLNALLGAYHALYLPLEVREMRP-TTGL------KAQHLGV---KEDTKGSDEL--VLRLAMALEEG-----------------------------------------RWLARDIGGSDPERMAAPRIVDYLKTSLGGM-----KGITMSV---EKVDIQKYPLMAAVNRAASVVARHDGRVVHLKYEPP---------NPTEVDTT----LY---------------------------LIGKGITYDTGGADIK--ANGVMAGMHRDKCGAAAIAGLFKTLGEL------------------Q---PPGLSVSAALAFVRNSVGADSYVADEILVARSGQRIRVGNTDAEGRMVMTDLLCEAKE---------------------------KAIN----ATNPF------LFTIATLTGHVVRAY-KHYTAVMDNGPPRIHRVSQSLQEAG---------------DRISDMAEISTVRKEDYEFNRGKTEYEDTLQCNNLPSSATPRG-----------HQIPAAFMALAS------GLDKHGLGSAK-PIPYTHVDVAGS-----ATEIHV-----LP--TAAPLLMFASRYVLPRLGFK 130
 131 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------------------------------------RTLARDIGGSDPERMAAPKIAEYLQNALNGL-----KGVTVTV---DKVDAKKYPLMAAVNRAASVVPRHDGRVVHVDYKPS---------NSKEIDTS----LF---------------------------LVGKGITFDTGGADVK--AGGIMAGMHRDKCGAAAIAGLMKTIGLL------------------Q---PDGISVSAGLAFVRNSIGSESYVADEIIIARSGQRVRIGNTDAEGRMVMADLLCEAKE---------------------------KALT----TKNPF------IFTIATLTG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- 131
 132 -----------DNLEVALNRAARC-------------DTLCVIDDANLHPVLAREIEQQKTFDAGICSEVSCFRCTVGSEPVRVVYSPVGELS-DFDDVRRYAEAAGQAMRRALKAGAKFPLLVLPAPTER--------------FSAAPLVALLGALHELYVPLQLREDVP-AKRQ------RYAKIGL--LHPDGAQRGQD--LLRQVQSLEAG-----------------------------------------RFVARDIGGGDPERMAPPRVAEYVLQAFA-G-----GPVKVTVVDDPRVFERDYPLFQAVNRAAGTVERHRGRIVFLEYR-----------PPKPARKT----VV---------------------------LVGKGVTYDTGGADIK--AGGVMAGMSRDKCGAAAVAGFMKVVEQR------------------Q---PQDVHAIGVLCMVRNSVGEECYVSDEMVTSRAGVRVRVGNTDAEGRMAMADALCQMKE---------------------------RVLSEG--LPDPH------LYTVATLTGHAMLAVGN-SAIVMDNGPARAANHGPELQRAG---------------EVVGDPFEISVLRREDFDFHRGKCYGEDVLQANNLPSSRTPRG-----------HQGPAAFLMLAT------GLDKCGLSSTH-PIKYSHLDIAGS-----AGDVPD-----TP--TGSPILALAQAHLQ------ 132
 133 ---------------MGIEKILPCTLRLNKLMSLAGNDCLCIIDRNAVPNELKATFEEHRKFDKSFDSSISCFKVPNVDQP--VVYAPVSELT-DYDDVRSYQEAAKRSMEKVLKAGFHTPLLFVPK-VKR--------------FPEVELCTVLGALEQLYVPIQLREAGT-LKDP------RVTTLSV--QIDD--PRAEA--IFQEALILEAG-----------------------------------------RFVARDIGVGDPERMTPIQVEKYIKPLF--------DKLNVNVISDTQVLQKEYPLFAAVNRAADAVERHRGRIIFLEYK-----------PPKPARKT----LM---------------------------LVGKGVTYDTGGADIK--AGGVMAGMSRDKCGAAAVAGFMQVVSQL------------------Q---PDDIHVVAALCMVRNSVGEECYVADEVITSRAGLHVRIGNTDAEGRMCMTDALCRMKE---------------------------LVVEQN--LPDPH------LFTIATLTGHAFISAGEGQSIAIDNSVAHREDHARRLQAAG---------------QAFGEPFEVSILRPSDFSFNAGKVIGEDLVQANNAPSVRTPRG-----------HQVPAAFMIKAS------GLDKHGLDSML-PIKYTHIDIAGS-----AGEHPA-----MP---------------------- 133
 134 ---------------------------------------------------------------------VHTLTCRSLPSK-RLVVSFTGHLDQDIDDARRITEASTKGISQAIKIGSKRPLLLLGPLKTAKKLEHCWLE-----PSVSCLASLLGALHALYVPLEVREFDR-QEGSTCTKPIQSQKAEVLGWFSGTHYAVDHEKLTXLAWCLEEG-----------------------------------------LRVARDIGGSDPERMSAKNIVTYLQKELT-E-----P-VQFT---DCPVDRGLYPLAAIVDRGNN--ERHRGRVVHLEYNGS---------TESEIDPQQLVNLF---------------------------LVGKGVTYDTGGSDLK--VGGIMATMHRDKCGAAAVAGFFKVLNLL------------------K---PKNLKVHGTLGLVRNSIGENAYVSDEIVTSRAGVRVRVNNTDAEGRMVMTDLLCEAKE---------------------------KALK----VSNPR------LMTIATLTGHVALCYGLGYTGIVCNGPAKELGEDYDYQFAG---------------SLLGEMHEISTLRREDYDAHKTDEEYADLLNSARLIGGKRSRG-----------HQSPVAFMIIAS------GLDSHLKNTEK-PLAYTHMDIASS-----NGPCPG-----IP--TGTPILTLASRYI------- 134
 135 ---------------------------------------------------------------------VHVIYCEELPSH-TLVVSFTGALDRDFDDIRRITDASKDGIAQALKAGSTKPMLALAPFKTASKLRCSWTD-----PKSLCLAALLSALHELYVPLEVREFSMLPRTAELTKSIKASKVDSLFWFSGSHYAVDHSKLIHVAWCLEEG-----------------------------------------RRVARDIGGSDPERMRASHIVDYLKAEFA-D-----SGVTFR---SGPVDAKLYPLAAVVDRGSN--DSRRESIVHLEYRGS---------VDKNMKDTDVTDLF---------------------------LIGKGIIYDTGGSDLK--VGGIMATMHRDKCGAAAVAGFFKSTSLL------------------K---PKNLNLLGSLALVRNSIGSSAYVSDEIITSRAGTRVRVNNTDAEGRMVMTDLLCEAKE---------------------------QALR----LPKAF------LMTFATLTGHVVLSYGPNYTGLVCNGPARLLKMDHIFQQSG---------------ELLGEMSEISTLRREDYEAHKAHEPYADLLNSARPVGGKRVRG-----------HQSPAAFMIVAS------GLDSHMCNSKK-PLPYTHFDIAGS-----QGTCPG-----IP--TAAPLLTLASQYL------- 135
 136 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------G-----------------------------------------RRIAKDIGNPDPEIMSPIHIVEYIQEQFKDA-----KNIKLSVIDDVEAIRKEYPLAHAVTRASLAVPRHHPRFVLFEYLSP---------DQSQVKEN----LY---------------------------FVGKGVTYDTGGADVK--CSGHMRDMSRDKCGAAAVAGFFKTISML------------------A---PEKVNVTGGLALVRNSVGPDMYVSDEVIVARS---VLVGNTDAEGRMVMTDLLCQFKE---------------------------KVIEHNQ-SNTPSSSAPSFLFTCATLTGHALRAY-DGYGITLDNGVARKHKISKRIYNAG---------------HVLADPFEISTLRREDIDCVKPGRSSEDLISANDQPSTMTNRG-----------HQYPAGFMLQAS------GLDQYGLNNKELSIGYTHLDVAGS-----AELISS-VGWSLPRVTGSPVVALTGAFLF------ 136
 137 --------------------------------------------------------------------------VPGLPAN-RLVLAPVVSILGDTDDVRRYNDAARAAIARACSAGIRCPTILLFDNPITASAGSPFAARVAVDYSMYLKVTLLGILYEIYQPLQTREHLA-QKATASSAALSVAYFAA---VGTPLPELKQ--AIQWALATDHG-----------------------------------------RCIARDIGGSDPERMAPLRCAQYIENAFKGV-----ENIKVTVVRDVDLIKKEYPLLHAVTRCALAVPSHFPAVVRLEYHSP---------DPSKVKEN----LF---------------------------LIGKGVTYDTGGADIK--HDGAMRGMSHDKCGASACAGFMKTVSLF------------------K---PTGVNVIATLGFVRNSVGAASYVSDEILVSRAGVRVLVGNTDAEGRMVMADLLAEAKE---------------------------NALSDRYAAIPSR------LLTVATLTGHAYMATGEGYTLSLDNGPAREGAVSDRLFKAG---------------HASGDPFERSSLRREDFKFIVPTSSTEDVVQANSLPSTRTARG-----------HQYPAAFLSVAS------GIVEHGLDSLH-PISYTHVDIAGS-----AEESLGGLSLSRA--TGAPVSALTTAFL------- 137
 138 ------------------------RKFKLVEL----------------------------------HSIVLKQ-------------------------------------------------FLTLP----------------------------------------------------------AVFQV-------GESDTSSQLEKLVAAYDAS-----------------------------------------FTVCRDVGETGPERMAPPRVAEYVQGAFA-N-----GNIKVTVVDDQSVILKDFPLMAAVNRAANAVKEHQARLIRLEYV-----------GEGETQDT----FF---------------------------VVGKGVTIDTGGCDLK--TGGHMFGMCRDKYGSAVVGGFFKAIDVL------------------K---PKNIKAVGYMCMVRNSIGSRAYTCDEVITSRSGKRIHIYNTDAEGRLTMLDPLTLAKE---------------------------EALK----AKNPH------LFTVATLTGHEVLSYG-YYAAIMDNGPAKASGWARKVQEVG---------------DEFGQPIEISRLHPEDFAFHLAECEQADLRQGNTKPSVATLRG-----------HQTPAAFLQMAS------RIDEHGTDSSH-PLKYTHIDMGGC-----EGDHPS---VSFP---------------------- 138
 139 ---------------IVRAASIADAAFDAVVLVGSQESVTQFGAIKQVSAIAPVVDKFLKLHNGAFHSTSLVQVDSSVVPSGRLILAGTGHVSRDYDDVRRYQAAARKGIELALSAGVKSPLLVTLPNSR---------------FPNAELVAALGALTPVYTPLNVREEENKQKLH------QLGLLAV-------GESDTSSQLEKLVAAYDAS-----------------------------------------FTVCRDVGETGPERMAPPRVAEYVQGAFA-N-----GNIKVTVVDDQSVILKDFPLMAAVNRAANAVKEHQARLIRLEYV-----------GEGETQDT----FF---------------------------VVGKGVTIDTGGCDLK--TGGHMFGMCRDKYGSAVVGGFFKAIDVL------------------K---PKNIKAVGYMCMVRNSIGSRAYTCDEVITSRSGKRIHIYNTDAEGRLTMLDPLTLAKE---------------------------EALK----AKNPH------LFTVATLTGHEVLSYG-YYAAIMDNGPAKASGWARKVQEVG---------------DEFGQPIEISRLHPEDFAFHLAECEQADLRQGNTKPSVATLRG-----------HQTPAAFLQMAS------RIDEHGTDSSH-PLKYTHIDMGGC-----EGDHPS---VSFP----NPLVTLVAGLVLPHV--- 139
 140 ---------------IVRATSIADAAFDAVVLVGSQDNVQQFGAIQQVSAIAPAVNNFLKLHSGAFNSTSLVQVDSSVVPSGRLILSGTGNVSRDYDDVRRYQAAARKGISMALSAGVKSPLLITLPNSR---------------FPNAELVAALGALTPVYTPLNVREEENKQKLN------QLGLLAI-------GNSDTSARLEKLVEAYDAS-----------------------------------------FTVCRDVGEAGPERMAPPRVAEYIQGAFA-N-----GNIKVTVVDDQSVILKDFPLMAAVNRAANCVKEHQARLIRLEYV-----------GEGETQDT----FF---------------------------VVGKGVTIDTGGCDLK--TGGHMFGMCRDKYGSAVVGGFFKAIDVL------------------K---PKNIKAVGYMCMVRNSIGSHAYTCDEVITSRSGKRIHIYNTDAEGRLTMLDPLTLAKE---------------------------EALN----AKNPH------LFTVATLTGHEVLSYG-YYAAIMDNGPAKASGWARRVQNVG---------------DEFGQPIEISRLHPEDFAFHMAECEQADLRQGNTKPSVATLRG-----------HQTPAAFLQMAS------RIDEHGTNSSH-PLKYSHIDMGGC-----SGDHPS---VSFP----NPLVTLVAGLVLPHV--- 140

     Active site residue:           X

     Metal binding site:            X

     Putative:              +

     Experimental:          #