Alignment for family A8
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
123456789012345678901234567890ABCDEFGH12345ABCDEF678901234A5ABCD67890123456789ABCDEFGH0123A456789012AB34567890123456789ABCDE0123456789012345AB6789012345ABCDEFGHIJK67ABCDEFGHIJKLMN8ABCDEFGHIJKL90123456789012ABCDEFGHIJKL34ABCD567890123456789012345678901234
+ + + + + ++ ++ +
1 ------------FICFAVLVSIDQLSKCIV--------RDQLP------LFAKRPFLEGI----IEFYHVENSGAAFS----F-------AEG--ARPFF--VICALVTLVVIFYYLI------RKCTDLYLGRTLMLIA--AGALGNLLDR-----------LI--------------F------------HTVCDFFATQF-----I---------SF----PIFNIADIYVTLGACGLFVYSYV------- 1
2 ------------FVFIISLIFFDQLSKYLV--------AKYVEL-----GSIYFSFFDDF----FRIIHVRNTGILFS--------MGSNIHYSLKKIFF--LAMPIFILIFVFYLS-------LKERNCIARISLLLIF--SGGVGNVIDR-----------LFRP-------------------------SGVVDFLDLKFYGIFGLD--------RW----PTFNFADSYVVIGMILFLVYDFFIKRK--- 2
3 SFLSRLPQGKVVAALIVLLLVVDQVIKIWV--------KTTMV------LGQSHVVAPW-----FQIHFVENPGMAFG--------IELG-----SKLFL--SLFRIVAMGFCIYLLAKLVR--KREHTLAFLSCLSLII--AGGIGNIIDS-----------IFYGVIFSGSHGQIAQLFPSGGGYETWFHGRVVDMFYFPLIEGVFPSWLPFWGGEEFVFFHPVFNFADSCISIGLILLLVCYPRTVSLLLD 3
4 -----------------VLLFIDQATKIIV--------KNTFM------LHETREVIPGF----FNLTYILNPGAAFG--------FLARMNENYRQLFF--VLITLIAIAAVAYLLYK-----EH-SMKLRAFSYTLII--AGAVGNFIDR-----------VY--------------I------------GKVVDFLDFYVSDY------------HW----PAFNVADSAISVGVCFLMLDL--------- 4
5 ----MKPTYRIFNAVVLGSLVLDQATKVLI--------DRTMD------LYQSIPVIDGL----FSITYLRNRGAAFS---------FLA-DFSYRLPFF--ILVSVVALGVIAVTFRKLRD-----DQHLAAAALALIF--SGALGNLIDR-----------VR--------------L------------GEVIDFLDVYWKTY------------HW----PAFNVADSAICVGVALLAVDMIREER---- 5
6 -----------------LLVVADQASKVFM--------DTWLF------LGQSVPVIPGF----FQWTLVYNPGAAFG--------LLGG-LDASLRIGF--FVVVGCVALAVCVYLY------RHGSTWFHRQGALLIA--AGAIGNMIDR-----------VR--------------L------------GYVIDFFD---VFLGSY---------HW----PAFNVADICITVGAACYAVALTME------ 6
7 ----------------VFSIVSDQLTKLWA--------VARFTDEAGNFTYEKIPVIGEL----VRFQLVYNKGAAFSSRPQDLMPFLP------PWLFF--LLIS-IVAAFALA--WFYKS--IDKRDYLSRLGVVMIL--GGAVGNFIDR-----------MR--------------M------------QMVVDFIDCDFPDFIMT---------RF----PTFNVADSFVTVGVALVILS---------- 7
8 --------------ISIAVVIIDQLSKFFVKGFSIPFLNFNFDGMY---YGQSIPVIGDF----FRLTYIENPGMAFG--------FDPG---DGFKLAI--SLFSLIASVGLLIYLYA-----IRNKSLSLRIAIAFIL--GGAVGNLIDRTFYGVFFGYAPLF--------------Y------------GRVVDFFDFDFFDFTLFGRSYD----RW----PIFNIADAAVTVGVLILILFY--------- 8
9 ---------------------IDQLFKYLV--------RNFMD------YGQSIPIINGF----FQLTSHRNTGAAWG--------IFSG-----QKIFL--ISIAIIVIVIGLIYSR-------KVTDKLTRIAFGFYI--GGAMGNVVDR-----------LI--------------F------------GEVTDMFEVTFI--------------NY----PIFNTADVFLVSGVILFLISTYKE-SKVEK 9
10 --------------------LIDQLAKYAV--------RTYMQ------LGETIPIAGDY----FQLTSHRNNGAAWG--------IFAG-----QRWFL--ILITLVAIIFLIRYAR-------NTTDKWTRYALGLYM--GGALGNAIDR-----------IA--------------F------------GEVVDFFNVRII--------------NY----PIFNTADTFLVCGTILLVITTFKQPNNVAK 10
11 ----------------------DQLTKWLV--------VKNME------LGQSIPIIDQV----FYITSHRNTGAAWG--------ILAG-----QMWFF--YLIT-TAVIIGIV--YYIQR--YTKGQRFLGVALGLML--GGAIGNFIDR-----------AV--------------R------------QEVVDFIHVIIV--------------NY----PIFNIADSSLCVGVMLLFIQMLLDSGKKKK 11
12 ---------MLYYVIALLIIAADQLTKWLV--------VKNME------LGQSIPIIDQV----FYITSHRNTGAAWG--------ILAG-----QMWFF--YLIT-TAVIIGIV--YYIQR--YTKGQRLLGVALGLML--GGAIGNFIDR-----------AV--------------R------------QEVVDFIHVIIVNY------------NY----PIFNIADSSLCVGVMLLFIQMLLDSGK--- 12
13 ------------YLIALFIIIADQLTKWLV--------VSHME------LGQSIPVIDQV----LYITSHRNTGAAWG--------ILAG-----QMWFF--YVIT-IAVIIGIV--YYIQR--YAKGQMLLGISLGLML--GGAAGNFIDR-----------AA--------------R------------QEVVDFIHVIIVNY------------QY----PIFNIADSSLCVGVILLFIHMLFDSG---- 13
14 ---------------------IDQFTKWLV--------VSKME------YGESILVIDGF----FQITSHRNTGAAWG--------ILAG-----QMWFF--YIIT-TAVIIGIV--YYIQK--HAKGQILLGTALGLML--GGAVGNFIDR-----------VF--------------R------------QEVVDFIHVTIVNY------------HY----PIFNIADSSLCVGVLLLFIQMLLDGKKKKE 14
15 ---------------------IDQVSKWLI--------VKNME------LGTSIPIIDNV----LYITSHRNRGAAWG--------ILEG-----QMWFF--YIIT-IVFVGFIV--IYMKK--YAKTDRLLGVSLGLIL--GGAIGNFIDR-----------IF--------------R------------QEVVDFIHVYIFSY------------NY----PVFNIADSALCIGVVLIIIQTLLEGKKMKE 15
16 --------------IALFVIAIDQVSKWLI--------VKNME------LGTSIPIIDNV----LYITSHRNRGAAWG--------ILEG-----QMWFF--YIIT-IVFVGFIV--VYMKK--YAKTDMLLGVSLGLIL--GGAIGNFIDR-----------VF--------------R------------QEVVDFIHVYIFSY------------NY----PVFNIADSALCIGVVLIIIQTLLEGKKMKE 16
17 YTVFVGEMKMIYYVIALFVIAIDQISKWLI--------VKNME------LGTSIPIIDNV----LYITSHRNRGAAWG--------ILEN-----KMWFF--YIIT-VVFVVFIV--FYMKK--YAKTDRLLGISLGLIL--GGAIGNFIDR-----------VF--------------R------------QEVVDFIHVYIFSY------------NY----PVFNIADSALCIGVVLIIIQTLLEGKKAKE 17
18 ------------YVIALFVIAIDQISKWLI--------VKNME------LGTSIPIIDNV----LYITSHRNRGAAWG--------ILEN-----KMWFF--YIIT-VIFVAFIV--FYMKK--YAKTDKLLGISLGLIL--GGAIGNFIDR-----------VF--------------R------------QEVVDFIHVYIFSY------------NY----PVFNIADSALCIGVVLIIIQTVLEG----- 18
19 -------------------------------------------------------------------------------------------------------------------------Q--EKGKSKFALTTYSLLL--AGALGNFIDR-----------VR--------------L------------GFVVDMFQFEFID--------------F----PIFNIADICLTVGVAALFLYILIVE----- 19
20 ------------FLISALLVGLDQWSKYLT--------VQNIS------LGETKEFIPGF----LSLTHLRNTGAAWS--------LLEG-----KMIFF--YVIT-VIVSVVII--YLLIK--NYKKSIWYSVGLSFVL--AGAIGNFIDR-----------VR--------------L------------GYVVDMLQTDFMN--------------F----PIFNVADSTLVVGVICIFIYLILDE----- 20
21 -----------------------------------------------------KPFIPKI----LSLTYLRNTGAAFS--------ILEN-----QQWLF--AVIT-LVVIGAAI--WYLSK--HIKGSVWLLSALSLII--AGGIGNFIDR-----------MR--------------Q------------GFVVDMFQLNFIN--------------F----AIFNVADSYLTIGVLVLIVMMLKEE----- 21
22 --------------LIAGLIGLDQLAKWWT--------VTNIE------LDTSREWISGF----MSLAYLRNYGAAYS--------MLQN-----QQWLF--TIIT-LVVMTAAI--WYFIK--QIDGSLWQLFALSLII--AGGLGNFVDR-----------LR--------------L------------GYVVDMFKTEFID--------------F----PVFNVADACLTVGVAVLFICILKEE----- 22
23 ---------------------LDQLSKFWI--------VSHIA------LGEVKPFIPGI----VSLTYLQNNGAAFS--------ILQD-----QQWFF--VVIT-VLVIGYAI--YYLAT--HPHLNIWKQLALLLII--SGGIGNFIDR-----------LR--------------L------------AYVIDMVHLDFVD--------------F----AIFNVADSYLTVGVILLVI----------- 23
24 --------------SSIFLIALDQFSKYWI--------VSHIE------LGQIKPFIPGI----VSLTYLQNNGAAFS--------MLQN-----QQWFF--VIMT-ILVIGYAI--YYVMT--HRQLTIWKQLALLLII--SGGIGNFIDR-----------LR--------------L------------SYVIDMVHLDIID--------------F----AIFNVADAYLTLGVILLVVCLWKEE----- 24
25 MSQSICSTGLRWLWLVVVVLIIDLGSKYLI--------LQNFA------LGDTVPLFP-S----LNLHYARNYGAAFS--------FLAD-SGGWQRWFF--AGIAIGISVILAVMMYR-----SKATQKLNNIAYALII--GGALGNLFDR-----------LW--------------H------------GFVVDMIDFYVGDW------------HF----ATFNLADTAICVGAALIVLEGF-------- 25
26 MSQSICSTGLRWLWLVVVVLIIDLGSKYLI--------LQNFA------LGDTVPLFP-S----LNLHYARNYGAAFS--------FLAD-SGGWQRWFF--AGIAIGISVILAVMMYR-----SKATQKLNNIAYALII--GGALGNLFDR-----------LW--------------H------------GFVVDMIDFYVGDW------------HF----ATFNLADTAICVGAALIVLEGFLPSRAKKQ 26
27 MSQSICSTGLRWLWLVVVVLIIDLGSKYLI--------LQNFA------LGDTVPLFP-S----LNLHYARNYGAAFS--------FLAD-SGGWQRWFF--AGIAIGISVILAVMMYR-----SKATQKLNNIAYALII--GGALGNLFDR-----------LW--------------H------------GFVVDMIDFYVGDW------------HF----ATFNLADTAICVGAALIVLEGFLPSKSEK- 27
28 ------------------------------------------------------------------------------------------------------------ISVILAVMMYR-----SKATQKLNNIAYALII--GGALGNLFDR-----------LW--------------H------------GFVVDMIDFYVGDW------------HF----ATFNLADTAICVGAALIVLEGFLPSKAKKQ 28
29 -----------------------MGSKYLI--------LQNFA------LGDTVPLFP-S----LNLHYARNYGAAFS--------FLAD-SGGWQRWFF--AGIAIGISVILAVMMYR-----SKATQKLNNIAYALII--GGALGNLFDR-----------LW--------------H------------GFVVDMIDFYVGDW------------HF----ATFNLADTAICVGAALIVLEGFLPSKAKKQ 29
30 --------------------------------------------------------------------------------------FLAD-SGGWQRWFF--AGIAIGISVILAVMMYR-----SKATQKLNNIAYALII--GGALGNLFDR-----------LW--------------H------------GFVVDMIDFYVGDW------------HF----ATFNLADTAICVGAALIVLEGFLPSKAKKQ 30
31 --------------------IIDLGSKYLI--------LQNFA------LGDTVPLFP-S----LNLHYARNYGAAFS--------FLAD-SGGWQRWFF--AGIAIGISVILAVMMYR-----SKATQKLNNIAYALII--GGALGNLFDR-----------LW--------------H------------GFVVDMIDFYVGDW------------HF----ATFNLADTAICVGAALIVLEGFLPSKAKKQ 31
32 MSQSICSTGLRWLWLVVVVLIIDLGSKYLI--------LQNFA------LGDTVPLFP-S----LNLHYARNYGAAFS--------FLAD-SGGWQRWFF--AGIAIGISVILAVMMYR-----SKATQKLNNIAYALII--GGALGNLFDR-----------LW--------------H------------GFVVDMIDFYVGDW------------HF----ATFNLADTAICVGAALIVLEGFLPSKAK-- 32
33 ----------------------------------------------------------------------------------------------------------------------------------------------------LFDR-----------LW--------------H------------GFVVDMIDFYVGDW------------HF----ATFNLADTAICVGAALIVLEGFLPSKAKKQ 33
34 ------------LWLVVVVLIIDLGSKYLI--------LQNFA------LGDTVPLFP-S----LNLHYARNYGAAFS--------FLAD-SGGWQRWFF--AGIAIGISVILVVMMYR-----SKATQKLNNIAYALII--GGALGNLFDR-----------LW--------------H------------GFVVDMIDFYVGDW------------HF----ATFNLADTAICVGAALIVLEGFLPSK---- 34
35 ----------------------------------------------------------------------------------------------------------------------------SKATQKLNNIAYALII--GGALGNLFDR-----------LW--------------H------------GFVVDMIDFYVGDW------------HF----ATFNLADTAICVGAALIVLEGFLPSKAKKQ 35
36 ------------LWLVVVVLIIDLGSKYLI--------LQNFA------LGDTVPLFP-S----LNLHYARNYGAAFS--------FLAD-SGGWQRWFF--AGIAIGISVILMVMMYR-----SKATQKLNNIAYALII--GGALGNLFDR-----------LW--------------H------------GFVVDMIDFYVGDW------------HF----ATFNLADTAICVGAALIVLEGFLPSK---- 36
37 MSQSICSTGLRWLWLVVVVLIIDLGSKYLI--------LQNFA------LGDTVPLFP-S----LNLHYARNYGAAFS--------FLAD-SGGWQRWFF--AGIAIGISVILAVMMYR-----SKATQKLNNIAYALII--GGALGNLFDR-----------LW--------------H------------GFVVDMIDFYVXDW------------HF----ATFNLADTAICVGAALIVLEGFLPSKAXK- 37
38 ------------LWVVVAVLIIDLGSKFLI--------LQNFA------LGDTVSLFP-S----LNLHYARNYGAAFS--------FLAD-SGGWQRWFF--AGIAIGICVILAVLMYR-----SKATQKLNNIAYALII--GGALGNLFDR-----------LW--------------H------------GFVVDMIDFYVGDW------------HF----ATFNLADTAICIGAALIVLEGFLPS----- 38
39 ------------------------------------------------------PLFP-S----LNLHYARNYGAALS--------FLAD-SGGWQRWFF--SGIAIGICVVLTVLMYR-----SKATQKLNNIAYALII--GGALGNLFDR-----------LW--------------H------------GFVVDMIDFYVGDW------------HF----ATFNLADSAICIGAALIVLEGFLPKPTVKE 39
40 ------------LWVVVAVLIIDLGSKFLI--------LQNFA------LGETVPLFP-S----LNLHYARNYGAAFS--------FLAD-SGGWQRWFF--SGIAIGICVVLTVLMYR-----SKATQKLNNIAYALII--GGALGNLFDR-----------LW--------------H------------GFVVDMIDFYVGDW------------HF----ATFNLADSAICIGAALIVLEGFLP------ 40
41 -------------------LVTDLFSKYIV--------VQRFE------LYESINVMP-M----FNLTYARNYGAAFS--------FLAD-HSGWQKYFF--LGLAVIISVALIVMLFK-----NKAELKLQNSAYALII--GGAIGNAIDR-----------AY--------------H------------GYVVDFFDFYWDIY------------HY----PVFNVADIGIVIGAGLLILESLLDSRK--- 41
42 ----------------------DQAIKWLV--------QQSMA------YGESISVTS-F----FNWVHVWNTGAAFS--------LFAN-GGGWQRYFF--IGIAVVVSIFLIKLILE-----NR--HKGEAIAYSLIL--GGAMGNLIDR-----------VF--------------R------------GYVVDSFDFYWRDW------------HW----PAFNLADIAIVLGALLFVSSSLLGKKA--- 42
43 LIIGKKLSPYALLSISGLLAASDQAVKWLV--------QQSMA------YGEYVSVTP-F----FNWVHLWNTGAAFS--------LFAN-GGGWQRYFF--IGIAVVVSIFLIKLILE-----NR--HKGETIAYSLIL--GGAMGNLIDR-----------VF--------------R------------GYVVDSFDFYWRDW------------HW----PAFNLADIAIVLGALLFVSSSLLGKKANTN 43
44 --------------------LLDQLSKYLA--------NHFLS------LGHPVKILP-F----LNFTLNYNTGAAFS--------FLGT-ENGWQIIFF--AAIS-FVVSIFLI--LWLSR--TSRSEIMMSLGLSLII--GGALGNFIDR-----------LR--------------W------------SYVTDFIDFHIKDW------------HF----ATFNVADSAICVGVFLLIVHMLLTPSSKP- 44
45 ------------LWFSVLVILLDQLSKYLA--------NHFLS------LGHPVKILP-F----LNFTLNYNTGAAFS--------FLGT-ENGWQIIFF--AAIS-FVVSIFLI--LWLSR--TSRSEIMMSLGLSLII--GGALGNFIDR-----------LR--------------W------------SYVTDFIDFHIKDW------------HF----ATFNVADSAICVGVFLLIVHMLLT------ 45
46 -----------WLWFSVLVILLDQLSKYLA--------NHFLS------LGHPVKILP-F----LNFTLNYNTGAAFS--------FLGT-ENGWQIIFF--AAIS-FVVSIFLI--LWLSR--TSRSEIMMLLGLSLII--GGALGNFIDR-----------LR--------------W------------SYVTDFIDFHIKDW------------HF----ATFNVADSAICVGVFLLIVHMLLTPSSK-- 46
47 --------------------LLDQLSKYLA--------NYFLS------LGHPVKILP-F----LNFTLNYNTGAAFS--------FLGT-ENGWQIIFF--ADIS-FVVSIFLI--LWLSR--TSRSEIMMSLGLSLII--GGALGNFIDR-----------LR--------------W------------SYVTDFIDFHIKDW------------HF----ATFNVADSAICVGVFLLIVH---------- 47
48 --------------------ILDQLSKLWV--------SQAMDP-----VGTTWPLWSGV----FHFTYVLNTGAAFS--------AFRG-GAGWLKW------LS-LAVSVGLI--IFAGK--VPLRKL-EQLGYGCIL--AGAVGNGIDR-----------FL--------------F------------GHVIDFLDFRLIN--------------F----PIFNLADVSINIGIAALLWASF--FP---- 48
49 ----MRLKNRLFWIAAFIAFFLDQITKYWV--------VQTFS------LGQTLPLLTGI----FHFTYVTNTGAAFS--------LLSG-KVEWLRW------LS-LGVSLVLI--ALALF--GPTLNLWDQLGYGLIL--GGAMGNGIDR-----------FV--------------L------------GHVVDFLDFRLIS--------------F----PVFNVADSFISIGIVFLLIASFQKTPTS-- 49
50 ------------YVILIIGLFLDQLTKYIT--------LTKLK------GVDSVVVIKDW----LEFTYVENTGVAFG--------SFSG-----YKYFF--IFISLVAFLAILFYINKN----KEKISKIEQVLYALIA--CGALGNCIDR-----------IR--------------F------------SFVVDFIHTRFGGLY-----------DF----PVFNFADIYICVACFLLIVISFSKK----- 50
51 ----------------------DQYSKFIV--------DSTLS------VGETVPIIENF----FNLTYVQNRGVAFG--------LFQG------KIDI--VSILAVVAIGLILFYFCKN---FKKISFLERIAYTMIF--SGAVGNMIDR-----------IF--------------R------------AYVVDMLDFRGI--------------WS----FIFNFADVWINIGVVLIIVEHIFF-NRKKR 51
52 CSSVEIGDSMIYIFLFLILLIIDQYSKFIV--------DSTLS------VGETVPVIDGF----FNLTYVQNRGVAFG--------LFQG------KIDI--VSILAVIAIGLILFYFCKN---FKKISFLERIAYTMIF--SGAIGNMIDR-----------LF--------------R------------AYVVDMLDFRGI--------------WS----FIFNFADVWINIGVVLIIVEHIFF-NRKKR 52
53 --------------------------------------------------GYSIPVLKDF----FNFTYVENHGGIFG--------IFQG------KINL--FTIASIILIAYVVFTEFKN---FKNYTKWTRIGVSVIA--AGALGNMIDR-----------IF--------------R------------GFVIDMIDFRGI--------------WG----FVFNVADMYVHIGIYIIVVDYLLK-KRKKK 53
54 ------------ILIIIASLALDQTTKWAV--------VQAIP------LYGKIELIPHF----FDLTYIQNIGAGFS--------IMEG----YGVVFF--SLITLIACAVIVYYF-------CTTEDRRIQSALSFVF--AGALGNWIDR-----------LR--------------F------------GYVRDFFSFRIFGQ------------SF----PVFNVADVCITMGFFSILLIL--------- 54
55 --------------LVPLLLAFDQILKLWA--------LENL-------SPIPRPLLGDL----LYLTLVKNTGAGFG--------LLQD-----KAQIL--GWVSLLVG-GVLLYLLGFRR--YPPA---VTLGLSLVA--AGALGNGVDR-----------LG--------------R------------GFVVDYLDLGTQIPLIA---------QF----PVFNLADVCVTLGAALLLL----------- 55
56 PTAPRRFPVWFPAVLVLVLIALDQWLKAWA--------LAHLQLN----AP-AIPVIPGV----LDWELTFNTGAAWS--------MFSG-----SAVPL--ALGRILVGLGILSYLL------WKPQGRFLTVVLSMIA--AGAIGNSIDG-----------LQ--------------R------------GQVTDMI----HSPLLSAVTEAINGTRF----PIFNIADMCVVGGTILLLVASLLPERKREK 56
57 ------------------LTLLLLASIDWVSKLVVLLKSCQLSPHSSAFLYS--YVWGHF---SFLIIPSFNEGAAFG--------LF-----TQYKIPL--LIFRVCVILGLALFLRIKYKSLHRRTR----IALTLIL--AGALGNVGDI-----------LL--------------Y------------GKVVDFLSLSYYSW------------RF----PSFNLADAFISIGTLLLIGHLYFTK----- 57
58 -------------AIAIVAVVLDQLTKFWA--------LSALAD-----DTHPIPIIGSL----LSFQLLHNSGAAFS----------LG-ET--STWVF--T---VLSVVIIGILIVGLSR--SVHVSAAACLG--LLG--GGAIGNLIDR-----------LIQPPGIG--------V------------GHVVDFINYNGFFVG--------------------NVADIWIVVGAIWLAW----------- 58
59 ------------WLLVCVLVLLDQITKNWA--------VAALGS-----QQR--MILGNL----LSFKLVYNSGAAFS----------LG-AN--TTWIF--TLIAFAACVALPIL---MWR--SRRFSSRLILG--VIW--AGALGNLIDR-----------LFRAPGYG--------Q------------GHVVDFINYCDFFVG--------------------NVADIELVVGAAGLILMEFF------- 59
60 ------------LAVAVLAVALDQGSKALA--------VAQLTS-----GER-VPLVGDL----FGLSLVYNPGAAFS----------LG-SG--STWIF--TLVGLLAAIAVVVFAVRL-R--GARWGAA--LG--LVL--GGAVGNLVDR-----------LLNPPSFG--------Q------------GQVTDFLAYGDLFVG--------------------NVADVFVVAGVGLLCLI---------- 60
61 ------------WVIVLVVVVIDFITKSLA--------VEHLTP-----RHIPHRIIGDV----VRFTLAYNPGAAFG--------MHLG-PG--SRWIF--ATL---AVVIVSVLLKATAE--LTRLSKLAAIGVPIVV--GGAIGNLVDR-----------IRMREG-------------------------VVDFI---DIGIGNT---------RF----WTFNVADSAVTIGAVCLILALWEQDKL--- 61
62 TPKRADVKLLIAVPVFLVVLILDLITKAVA--------VSVLAP-----SGAPISVIGEW----FRFALVYNPGAAFG--------LHLG-EY--SRWLF--MVLTGVALVVLWRLLRQSAEGDVRRL-----LAIALVA--AGAVGNVIDR-----------IRSELG-------------------------VVDFI---DIGIGLH---------RW----PTFNVADIAVSSGAFLLAIVLWREERD--- 62
63 ------------ALIAFIGVVLDRITKVWA--------LAALS------GGKNIDILPHL----LSFTLVRNPGASFG--------LGSS-----FTWVI--SVLACVACAAMIAVV-------KHTKSLYWTIALALAF--AGAFGNLIDR-----------AQYAQGFL--------N------------GKVVDFINY-----------------GW----SVGNVADIELMFAGIAVIC----------- 63
64 -------------LIIIVGIILDRITKLWA--------LKQLS------NGCEIEVIKNF----FSFNYLENRGAAFG--------IFQG-----KTALL--VSVTLVVMIGVI---YYFIK--YKPTSKFIRLGIALIV--SGALGNLYDR-----------IF--------------Y------------KYVVDFILIHYKNV--Y---------YY----PTFNIADILVVVGTIMLAIFLLRE------ 64
65 ----------MEILIIIVGIILDRITKLWA--------LKELS------NGREIEVIKNF----FSFNYLENRGAAFG--------IFQG-----KTALL--VSVTLVVMIGVI---YYFIK--YKPTSKFIRLGIALIV--SGALGNLYDR-----------IF--------------Y------------KYVVDFILIHYKNV--Y---------YY----PTFNIADILVVVGTIMLAIFLL-------- 65
66 -------------LIIIFGIILDRITKLWA--------LKELS------SGHEIEIIKNF----FSFNYLENRGAAFG--------IFQG-----KTVLL--VLVTLLIMIGVI---YYFIK--YRPTSRFMRIGVSFIV--SGALGNLYDR-----------IF--------------Y------------KYVVDFILIHYKNV--Y---------YY----PTFNIADILVVVGTIMLAIFLLR------- 66
67 -------------LVIIIGILLDRFTKVWA--------LKTLA------NGNEIELIKDF----FSFRYLENKGAAFG--------IFQG-----KTFLL--VLFTLIAILAII---YYVVK--YKPKSKFIKIGFACII--AGALGNLYDR-----------IF--------------Y------------KFVVDFILVHYKDV--Y---------YY----PTFNIADILVVVGTIMLGIFIL-------- 67
68 --------------VIIIGIFLDRFTKVWA--------LKTLA------NGNEIELIKDF----FSFRYLENKGAAFG--------IFQG-----KTFLL--VIFTLIAILAII---YYVVK--YKPKSKFIKIGFAFII--AGALGNLYDR-----------IF--------------Y------------KFVVDFILVHYKDV--Y---------YY----PTFNIADILVVVGTIML------------- 68
69 -------------LVIIIGILLDRFTKVWA--------LKTLA------NGKEIELIKDF----FSFRYLENRGAAFG--------IFQE-----KIFLL--VLFTLIAILAII---YYVIK--YKPKCKFIKIGFACII--AGALGNLYDR-----------IF--------------Y------------KFVVDFILVHYKDV--Y---------YY----PTFNIADILVVVGTIMLGIFIL-------- 69
70 ------------IIVLILGIFLDRISKIWA--------LNTLA------SGRDIVVIKNI----FSFSYLENRGAAFG--------IFQN-----RLIFL--SLITAIVILGVV---YFIVK--YKPTSKLLKISLSLII--SGAIGNLIDR-----------IY--------------Y------------KFVVDFIMLHYKDV--Y---------YF----PTFNVADMLVVIGTVLLAIYILK------- 70
71 -------------IVLILGIFLDRISKIWA--------LNTLA------SGRDIVVIKNL----FSFSYLENRGAAFG--------IFQN-----RLIFL--SLITAIVILGVV---YFIVK--YKPTSKLLKISLSLII--SGAIGNLIDR-----------IY--------------Y------------KFVIDFIMLHYKDV--Y---------YF----PTFNVADMLVVIGTVLLAIYILK------- 71
72 ----------MVIIVLILGIFLDRISKIWA--------LNTLA------SGKDIIVIKNL----FTFSYLENRGAAFG--------IFQN-----RLIFL--SLITAIVILGVA---YFIVK--YKPTSKLLKISLALII--SGAIGNLIDR-----------IY--------------Y------------KFVVDFIMLHYKDV--Y---------YF----PTFNVADMLVVIGTVLLAIYIL-------- 72
73 ------------IIILILGIVLDRISKIWA--------LNTLA------SGKDIVIIKNL----FSLSYLENRGAAFG--------IFQN-----RLIFL--SLITVIVILGVA---YFIVK--YKPTSKLLKISLSLII--SGAIGNLIDR-----------IY--------------Y------------KFVVDFIMLHYKDV--Y---------FF----PTFNVADTLVVIGTILLAIYILK------- 73
74 ----------YFFITALAVAIVDQATKIFF--------QKLLA------PGEIKIIIPGF----FNLVHVWNPGVAFG--------FFGN-SPHWARYLL--MGINLVAATGLYWL--------ARNKARSMQIFCGLVA--GGAIGNFIDR-----------FY--------------H------------SRVFDFLDFHIGPY------------HW----PAFNLADTSITLGVLGLIF----------- 74
75 ------------------VFLLDQLTKNWI--------------HQSLFPGEAIVVIPHF----FQIVSVRNTGIVFG--------MFQGDGENLHRMIL--VGVTVAAAAGI-----IYYSSRRRRERGFEFLPLALVL--GGALGNLSDR-----------VL--------------G------------GRVVDFLDFQVAGH------------HW----PAFNIADS---------------------- 75
76 --------DRYFYIIALSVLIIDQLSKIIV--------RKTIP------TGKEIPLIKGI----FSLTHITNSGSLFG--------MFQN------ATSI--LIVSSFFVTFLIIYIE------RKINLPYKEVAFGLIM--GGILGNLIDR-----------II--------------F------------RQVTDFLFLK----------------HW----PVFNIADASIDIGIAIFIISYLKHG----- 76
77 ------------------VIALDRLSKMWV--------QQNVP------EEGGITVIPHV----FRISHVLNPGAAFS--------LFTNSADPKRTHLL----LTGFSLFAIIIVLGVLLK--IGRRFTMTGLALALIL--GGAIGNVWDR-----------IV--------------Y------------KEVTDFLAVTIIHY------------HW----PDFNLADSAIVIGGCLLLLDALLGKKH--- 77
78 -------------ILCASIIALDQITKVMT--------IQATPYSPRLIR----EIIPGF----FNLVHYRNLGAAWG--------MGSS-----HTNIL--AIISFVAFFAILFEFPKLCE-----KRKINFLAISMML--GGIMGNGIDRA----------FR--------------P------------EGVVDMVEVFIPFVYKEGWY------RF----PAFNIADSAICVSVFIYIIASL-------- 78
79 MKSLVQARWITPILVAIIAVALDQASKRWI--------VATLGPEP---MTKFIPLIGED----IRLAYSHNTGIAFS--------LFHG-----KSDIL--TIVA-LVIITGAI-YLYITQ--LPNRRRLIQIAMGLIL--GGALGNVIDR-----------IR--------------L------------GYVVDFIQVGW----------------F----PIFNLADSAITVGAALLMLQ--YALDEIAL 79
80 -MMILRSRWMLLVLVAIPVFVIDQLSKVWL--------SDVL--LR---YNRPIPLLFDW----VQLAYHENTGVAFG--------LFPD-----QGGVL--SVGAGLVLLLLALTYQYI----LPADSRWITVAVGMIF--GGGLSNLVDR-----------IR--------------Q------------GYVVDFIQFGW----------------W----PVFNLADSAITIGVAALAFHIIFIGEEPAP 80
81 --------MALFYLLAIAAALLDRVTKLLA--------IHYLRD-----GAQSIVIIPDW----LKLTYAENLGIAFS------VRFLPP-----TGLLF--LTLAISAGVV-----WYVHK--SNNRSPLFLTAFGLIL--GGGIGNLIDR-----------VM--------------L------------GHVVDFIYFDLYHGALFGIPLD----LW----PIFNVADSCITIGACMIVLFHEKIFTRKHA 81
82 --------------LVLLIFLLDRITK--ELAERGYFSRLNIDFF-------------------LNFYLTHNYGVAFG----------ID----IARKII--LIFNFLALIVLVLLYRK-----FGF----IGLAFI--L--GGLLGNLYDR-----------V---------------------FY-----GYVIDFIH----LRNF----------F------VFNLADLFISLGGVLVFF----------- 82
83 --------------VVLIIFILDRITK--ELAERGYFSKINVDFF-------------------LSFFLTHNYGIAFG----------IE----FTRKII--LFFNLIALIVLIILYKR-----YEF----LGLAFI--L--GGLLGNLYDR-----------V---------------------FY-----GYVIDFIH----LKNF----------F------VFNLADLFITLGGVLVFF----------- 83
84 ----------------------DALNKLRELEPISF-----LDGT-------------------MNITRVHNTGVAFG----------LGNGTVWSSYLF--LAVPVLAIVVLVVLYRK-----NLFHTAWLKLAYVLLL--AGVAGNLTDR-----------LIQGFLIP--------YEQQHGFFTKLMNGYVVDFIDVTIPLFNY----------RW----PAFNVADSCIFVAAIIFFIASIFSAK---- 84
85 MENFLRKTAWLYLSIAVSVFLLDIITKNLA--------EKLFT--------THVEVFP-F----LEFYLIYNKGVAFG--------LLSELPDPLRLPLL--LITPVIALIITFLYALYSGD-------RIVAISMGLIG--GGALGNLYDR-----------LF--------------L------------GMVRDFIHLHIGEY------------YW----PAFNIADASISIGIALLILKYFFTKPALKN 85
86 ---------------------LDQISKAWA--------ASHLIPGI------SQKWIPFL----MRLELTTNTGAAFS--------LLHN-----SIFTL--TVISFIATISLIMLIFTRYI--SRSWQAL---AIALLL--GGSLGNGLDR-----------WR--------------L------------GYVVDFLALVPI--------------NF----PIFNEADISINLAIIC-------------- 86
87 -----------MAFVMVLTIVLDQLTKRIA-----------------SEIHGTFFIVPGF----LRFVKATNRGIALG--------LFKNLS---EQLLW--TVMFVVVFLSLLPYIFKFSR--------LERIAMGFIL--GGALGNLLDR-----------IR--------------F------------GYVLDFLNLTFLPT-------------------IFNLADVFIIVGGALMILGVFRGGDNESL 87
88 --------------SAIATVILDQASKLW------------LLHGFDLAHRGAVRVTPFF-----DLVLAWNIGISFG--------WLQN-DSQAAQLAL--MAVKAIAVVALAI-----WM--ARSHTLLATVALGLII--GGAIGNGIDR-----------LA--------------Y------------GAVVDF-ALFHLDIGGNTY-------NW----YVFNLADVAIVAGVAGLLYDSFLGVPA--- 88
89 ------------VLISIAVLVIDAFTKRLVSHVSEGTLI----------AGPYLGI--------FDIRFVKNTGAAWG--------IFSN-----ATFLL--GVFSVVLCTGVFVYFLTT----HHRMNWAQTIGLALII--GGGFGNAIDR-----------FA--------------L------------GYVIDFIETTFI--------------KF----PIFNVADMGVTCGIVIFLCGFFV------- 89
90 ---------FKAFWISIVVLMSDMISKYYAFHYLPKPLFESYWY-----PYGGIPVFQDFFGVQFSLNYVENRGAIGG--------IFAD-----FQEYL--LVFRILLIASLFCYLL------FYRYEKKLEIPLALII--GGAVGNIVDY-----------FL--------------Y------------GHVVDMLHFVLWGY------------DY----PVFNLADSAICIGIVWIFLYS--------- 90
91 ------------------------------------------------------------------LTYHENTGGMLS--------LGADLPENVRHIIF--TLMVGAVLLSGLAYLLI-----K-PMNKLSFSVGLLML--SGGLGNLYDR-----------VLN-------------E------------GRVVDFMLLQIGPL------------RT----GVFNVADVAIMAG----LFGFIFISSKSGK 91
92 ---------TLLIACLLFCVGCDQYTKKIA--------VEKLK------YEPPLTYLNNT----FRMEYAENTGAFLS--------VGSRLSKPVRFFLL--VVANAAFLILVTGMLVF-----RWQMPLVQFIALSLLL--AGGIGNLIDR-----------VFL-------------N------------GIVIDFLNIGFGPL------------RT----GIFNVADMAITGGALLMLFSWFFTKDQIEQ 92
93 -----------------------------------------------------------L----TWGFHL-NEGSALG----YWMPRVQAALGYWGIKFM--IFCG-VLAAGFFVWQM------QKVHSRSGQLGAIFLV--SGAVGNLVDR-----------LY--------------V------------GGVIDYLLLQMHGLVNT---------SF-----FWNLSDLYI-------------------- 93
94 -----------------AVCVIDQSIKWYS-------------------LNHLQKIGDAFDSGAFAFILHKNYGIAFD-------------------ISL--PLPITLAISALIILAIARFAILNRKNQPTRSAFAILVI--AGALGNLLDR-----------AV--------------L------------GYVVDYALLF----------------ER----SFVNLSDALIAFGIIGIAFSLSKK------ 94
95 -------------TIAFVVFALDQAIKLAF--------IVGFNFECEAFTLGNAQMYNAL---------VYNTGVAFS--------LFAF-----LGEWL--KFIQVLLLIALFAFTL------FGGLLAQHSIAFGLIF--GAGASNVFDR-----------FI--------------R------------DGVVDYVYWHYGF-------------EW----AIFNFADVMIDLGVGIIVIQMLFAKKK--- 95
96 --------------FFLSLMIIDQGIKIFI---------------KLFYFDAYIDIIPNL----LSFNPIINTDGSW---------LNARFGTNVSFPLL--ILFNIIALFVFVEIYRY--ALYKGNKDFWADMSFLFIF--CGALCSLIDK-----------LF--------------Y------------GGSLDFIGIS----------------NL----FIADIKDIYINLGILFFILTLFN------- 96
97 ----------------LILVLIDQSIKIYI---------YNNLMNKEFY------IFGSI----IGFSPIINTKYSY---------FNS-FG-NMEIGLITHIVLNIVMLFLILIIFDFIKERYSNNKIIYC----LFVLACAAAICSLIDK-----------VF--------------W------------GGSLDFISFK----------------NF----FIFDLKDVYISIFQIVAMLCI--------- 97
Active site residue: X
Transmembrane domain: X
Putative: +
Experimental: #
