Family I43
Summary for family I43
| Name | Inhibitor family I43 (oprin family) |
|---|
| Family type peptidase | I43.001 - oprin (Didelphis marsupialis), MEROPS Accession MER0019033 (inhibitor unit: 83-291) |
| Content of family | Inhibitor family I43 contains inhibitors of metallopeptidases from family M12. |
| History |
Identifier created: MEROPS 6.1 (10 January 2003)
Oprin (I43.001) was first isolated from the serum of the opossum by Catanese & Kress (1992). |
| Peptidases inhibited | Peptidases inhibited are in family M12 (Neves-Ferreira et al., 2002) and include jararhagin (M12.138), bothrolysin (M12.139) and BaP1 endopeptidase (M12.311). |
| Mechanism of inhibition | A hypothetical mechanism of inhibition has been proposed by (Neves-Ferreira et al. (2002)). |
| Molecular structure | Oprin has an immunoglobulin-like fold. This structure is stabilised by two disulfide bridges (see the Alignment) with a third inferred between Cys28 and Cys74 outside of the inhibitor unit (Neves-Ferreira et al. (2002)). |
| Clan | JM |
