Family C76


Summary Holotypes Alignment Tree Genomes Structure Literature Architecture

Summary for family C76

Family type peptidaseC76.001 - viral tegument protein deubiquitinylating peptidase (human herpesvirus 1), MEROPS Accession MER0045029 (peptidase unit: 49-221)
Content of familyPeptidase family C76 contains ubiquitinyl hydrolases.
History Identifier created: Merops 7.2 (14 October 2005)
Ubiquitinyl hydrolase activity was discovered within an N-terminal fragment of the UL36 protein from herpes simpex virus (C76.001; Kattenhorn et al., 2005).
Catalytic typeCysteine
Active site residuesC65 H199 
Active siteThe catalytic Cys65 has been identified by site-directed mutagenesis (Kattenhorn et al., 2005). The second member of a catalytic dyad may be the completely conserved His199.
Activities and specificitiesThe enzyme from herpes simplex virus is specific for release of ubiquitin from proteins ubiquitinylated via Lys48. Activity is only detectable following cleavage of the UL36 protein, which occurs late during viral replication. Activity has been shown towards ubiquitin-aminomethylcoumarin, ubiquitin-branched peptides and poly-ubiquitin (Kattenhorn et al., 2005).
Molecular structureThe tertiary structure of UL36 from murine herpesvirus 1 has been solved (Schlieker et al., 2007) and show a fold similar to that of papain (C01.001). Consequently, this family is included in clan CA.
Distribution of family Bacteria -  
Archaea -  
Protozoa -  
Fungi -  
Plants -  
Animals -  
Viruses details  
Biological functions
Statistics for family C76Sequences:40
Identifiers with PDB entries:1
Downloadable files Sequence library (FastA format)
Sequence alignment (FastA format)
Phylogenetic tree (Newick format)
Other databases INTERPRO IPR006928
PFAM PF04843
Peptidases and Homologues MEROPS ID Structure
viral tegument protein deubiquitinylating peptidaseC76.001Yes
Family C76 unassigned peptidasesunassigned-