Family I88


Summary Holotypes Alignment Genomes Structure Literature

Summary for family I88

Family type peptidaseI88.001 - oryctin (Oryctes rhinoceros) (Oryctes rhinoceros), MEROPS Accession MER0202144 (inhibitor unit: 20-66)
Content of familyFamily I88 contains serine endopeptidase inhibitors
History Identifier created: MEROPS 9.3 (7 September 2010)
Oryctin (I88.001) was isolated from the hemolymph of the rhinoceros beetle (Oryctes rhinoceros). It was shown to be an inhibitor of bacterial and mammalian serine endopeptidases from families S1 and S8, but its physiological role in unknown (Horita et al., 2010).
Peptidases inhibitedPeptidases inhibited include chymotrypsin A (S01.001), peptidase K (S08.054), subtilisin Carlsberg (S08.001) and elastase-2 (S01.131) (Horita et al., 2010).
Mechanism of inhibitionOryctin is proposed to inhibit serine peptidases by the Laskowski mechanism also termed the 'standard' mechanism (Laskowski & Kato, 1980).
Molecular structureThe tertiary structure has been determined and the fold shown to be similar to that of Kazal inhibitors (family I1) but with the C-terminal strand replaced by a helix (Horita et al., 2010). Consequently, family I88 is included in clan IA.
Distribution of family Bacteria -  
Archaea -  
Protozoa -  
Fungi -  
Plants -  
Animals details  
Viruses -  
Biological functions
Statistics for family I88Sequences:1
Identifiers with PDB entries:1
Downloadable files Sequence library (FastA format)
Inhibitors and Homologues MEROPS ID Structure
oryctin (Oryctes rhinoceros)I88.001Yes