Family I43
Summary for family I43
| Name | Inhibitor family I43 (oprin family) |
|---|---|
| Family type peptidase | I43.001 - oprin (Didelphis marsupialis), MEROPS Accession MER0019033 (inhibitor unit: 83-291) |
| Content of family | Inhibitor family I43 contains inhibitors of metallopeptidases from family M12. |
| History |
Identifier created: MEROPS 6.1 (10 January 2003) Oprin (I43.001) was first isolated from the serum of the opossum by Catanese & Kress (1992). |
| Peptidases inhibited | Peptidases inhibited are in family M12 (Neves-Ferreira et al., 2002) and include jararhagin (M12.138), bothrolysin (M12.139) and BaP1 endopeptidase (M12.311). |
| Mechanism of inhibition | A hypothetical mechanism of inhibition has been proposed by (Neves-Ferreira et al. (2002)). |
| Molecular structure | Oprin has an immunoglobulin-like fold. This structure is stabilised by two disulfide bridges (see the Alignment) with a third inferred between Cys28 and Cys74 outside of the inhibitor unit (Neves-Ferreira et al. (2002)). |
| Clan | JM |
| Distribution of family | Bacteria | details | |
| Archaea | - | ||
| Protozoa | details | ||
| Fungi | - | ||
| Plants | - | ||
| Animals | details | ||
| Viruses | details |
| Biological functions | Serum inhibitors such as those found in family I43 provide natural resistance to the effects of snake venom peptidases. | |
| Pharmaceutical and biotech relevance | Family I43 inhibitors are of interest in the development of new snake anti-venoms, particularly in the treatment of the local venom-induced effects (Trento et al., 2001. | |
| Statistics for family I43 | Sequences: | 12723 |
| Identifiers: | 3 | |
| Identifiers with PDB entries: | 3 | |
| Downloadable files | Sequence library (FastA format) | |
| Sequence alignment (FastA format) | ||
| Phylogenetic tree (Newick format) | ||
| Other databases | INTERPRO | IPR003599 | ||
| PANTHER | PTHR24100 | |||
| PFAM | PF00047 | |||
| SCOP | 49159 | |||
| Inhibitors and Homologues | MEROPS ID | Structure |
|---|---|---|
| oprin | I43.001 | Yes |
| alpha-1B-glycoprotein | I43.950 | - |
| immunoglobulin alpha Fc receptor | I43.951 | Yes |
| Family I43 non-peptidase homologues | non-peptidase homologue | - |
| Family I43 unassigned peptidases | unassigned | Yes |
