18 December 2018

Introducing a new species section for MHC allelic diversity in the domestic goat

A new section dedicated to the domestic goat has been added to the IPD-MHC Database.

Introducing a new species section for MHC allelic diversity in the domestic goat

With most of the major ruminant livestock species already represented on the IPD MHC Database we are now pleased to add the domestic goat, Capra hircus to the list. The development of a Caprine leukocyte antigens (CLA) section begins with assigning nomenclature to alleles at the MHC class II DRB1 locus from domesticated goats. These will be termed Cahi-DRB1 and are named in a single allelic series (Ballingall and Todd 2018). Other Loci will be added in due course and will follow the rules described in the recent report from the comparative MHC nomenclature committee (Ballingall et al. 2018, Maccari et al. 2018) in partnership with the IPD-MHC Database (Maccari et al. 2017).

  • Keith T. Ballingall and Helen Todd. An official nomenclature for MHC sequences from domestic goat (Capra hircus) HLA (2018), Published on line, DOI:10.1111/tan.13425
  • Keith T. Ballingall, Ronald E. Bontrop, Shirley A. Ellis, Unni Grimholt, John A. Hammond, Chak-Sum Ho, Jim Kaufman, Lorna J. Kennedy, Giuseppe Maccari, Donald Miller, James Robinson, Steven G.E. Marsh Comparative MHC Nomenclature: report from the ISAG/IUIS-VIC committee Immunogenetics (2018), 70, 625-632. doi.org/10.1007/s00251-018-1073-3.
  • Giuseppe Maccari, James Robinson, Ronald E. Bontrop, Nel Otting, Natasja G. de Groot, Chak-Sum Ho, Keith T. Ballingall, Steven G.E. Marsh and John A. Hammond IPD-MHC: nomenclature requirements for the non-human major histocompatibility complex in the next-generation sequencing era. Immunogenetics (2018), 70:619–623. doi.org/10.1007/s00251-018-1072-4.
  • Giuseppe Maccari, James Robinson, Keith T. Ballingall, Lisbeth A, Guethlein, Unni Grimholt, Jim Kaufman, Chak-Sum Ho, Natasja G. de Groot, Paul Flicek, Ronald E. Bontrop, John A. Hammond and Steve G.E. Marsh IPD-MHC 2.0: an improved inter-species database for the study of the major histocompatibility complex. Nucleic Acids Res. (2017), 45: D860–D864

Photo by Florian van Duyn on Unsplash

Edited by Dr. Keith Ballingall