Fully Sequenced KIR Haplotypes

The graphic below illustrates the gene compostion of a number of fully sequenced KIR haplotypes. Where possible the alleles sequenced at the genes are also listed. The allele designations will be displayed if you hover the mouse over the gene of interest. Clicking on the gene of interest will also take you to the entry page for the allele listed. Some genes are only partially sequenced and for these an allele designation is not provided. Clicking on the Source name will take you to the Cell Directory entry for the Haplotype source. The nomenclature for KIR haplotypes has not yet been implemented and the entry in the Hap. column uses a local designation for describing the haplotypes listed.

Source   Haplotype   3DL3 2DS2 2DL2/3 2DL5B 2DS3/5 2DP1 2DL1 3DP1 2DL4 3DL1/S1 2DL5A 2DS3/5 2DS1 2DS4 3DL2   Sequence
                                         
ABC08   A   3DL3*0090102 Not present 2DL3*0010102 Not present Not present 2DP1*0020103 2DL1*0030203 3DP1*0030202 2DL4*0010303 3DL1*025 Not present Not present Not present 2DS4*0010104 3DL2 partial sequence   View
G085   A   3DL3*0090101 Not present 2DL3*0010104 Not present Not present 2DP1*0020103 2DL1*0030206 3DP1*0030204 2DL4*011 3DL1*0050101 Not present Not present Not present 2DS4*010 3DL2*0010302   View
RSH   A   3DL3*0090101 Not present 2DL3*0010107 Not present Not present 2DP1*0020105 2DL1*0030209 3DP1*008 2DL4*0010307 3DL1*01701 Not present Not present Not present 2DS4*0010108 3DL2*023   View
FH06   A   3DL3*0090103 Not present 2DL3*0010103 Not present Not present 2DP1*005 2DL1*0030204 3DP1*0030202 2DL4*0010305 3DL1*008 Not present Not present Not present 2DS4*0030104 3DL2*00901   View
UV5HL9-5B   A   3DL3*00201 Not present 2DL3*0010111 Not present Not present 2DP1*0020101 2DL1*0030201 3DP1*0030201 2DL4*0080101 3DL1*0010101 Not present Not present Not present 2DS4*0030101 3DL2*0010101   View
LUCE   A   3DL3*00206 Not present 2DL3*0010106 Not present Not present 2DP1*008 2DL1*0030208 3DP1*00303 2DL4*0010202 3DL1*0150201 Not present Not present Not present 2DS4*0010101 3DL2*0020104   View
FH13   A   3DL3*012 Not present 2DL3*0010109 Not present Not present 2DP1*0020109 2DL1*0030210 3DP1*010 2DL4*00103 3DL1*01501 Not present Not present Not present 2DS4*00101 3DL2*013   View
G248   A   3DL3*048 Not present 2DL3*0010110 Not present Not present 2DP1*0020108 2DL1*0030204 3DP1*0030206 2DL4*0010201 3DL1*0290102 Not present Not present Not present 2DS4*0010102 3DL2*0020106   View
T7526   A   3DL3*00802 Not present 2DL3*0010108 Not present Not present 2DP1*0020106 2DL1*0030205 3DP1*0030202 2DL4*0010201 3DL1*0150203 Not present Not present Not present 2DS4*0010107 3DL2*0020105   View
FH05   A   3DL3*00101 Not present 2DL3*0020102 Not present Not present 2DP1*004 2DL1*0020102 3DP1*006 2DL4*0010304 3DL1*062 Not present Not present Not present 2DS4*0010106 3DL2*00903   View
FH15   A   3DL3*019 Not present 2DL3*0020103 Not present Not present 2DP1*0030102 2DL1*0020103 3DP1*006 2DL4*0080204 3DL1*00401 Not present Not present Not present 2DS4*0060102 3DL2*00501   View
FH08   A   3DL3*005 Not present 2DL3*006 Not present Not present 2DP1*007 2DL1*00303 3DP1*0030203 2DL4*0010306 3DL1*0150202 Not present Not present Not present 2DS4*0010105 3DL2*0020102   View
ABC08   AB   3DL3*0090102 Not present 2DL3*0010102 Not present Not present 2DP1*0020107 2DL1*025 3DP1*0030205 2DL4*0010308 3DS1*014 2DL5A by typing 2DS3/5 partial sequence 2DS1 partial sequence Not present 3DL2*056   View
GRC212   AB   3DL3*01001 Not present 2DL3*0010105 Not present Not present 2DP1*0020104 2DL1*0030207 3DP1*0030202 2DL4*00501 3DS1*0130102 2DL5A*0050103 2DS3*0020101 2DS1*0020105 Not present 3DL2*0070102   View
G085   BA1   3DL3*0140201 2DS2*0010102 2DL2*0010103 Not present Not present Not present Not present 3DP1*001 2DL4*00602 3DL1*0070101 Not present Not present Not present 2DS4*0040101 3DL2*008   View
FH06   BA1   3DL3*036 2DS2*0010106 2DL2*0030104 Not present Not present Not present Not present 3DP1*0090102 2DL4*0080105 3DL1*0010102 Not present Not present Not present 2DS4*0030103 3DL2*0010102   View
GRC212   BA1   3DL3*0040201 2DS2*0010107 2DL2*0030105 Not present Not present Not present Not present 3DP1*007 2DL4*0010201 3DL1*0290101 Not present Not present Not present 2DS4*0010109 3DL2*0020103   View
FH08   BA2X   3DL3 partial sequence Not present 2DL3*010 2DL5B*00601 2DS5*010 2DP1*006 2DL1*010 3DP1*00902 2DL4*0080203 3DL1*063 Not present Not present Not present 2DS4*0060101 3DL2*00202   View
FH13   BA2   3DL3*0140203 2DS2*0010111 2DL2*0010105 2DL5B*0080101 2DS5*007 2DP1*010 2DL1*0040102 3DP1*0030402 2DL4*011 3DL1*0050102 Not present Not present Not present 2DS4*010 3DL2*010   View
RSH   BA2   3DL3*0040202 2DS2*0010109 2DL2*0010104 2DL5B*004 2DS5*006 2DP1*009 2DL1*01201 3DP1*0030401 2DL4*011 3DL1*0050102 Not present Not present Not present 2DS4*010 3DL2*010 partial sequence   View
G248   BA2   3DL3*0030104 2DS2*0010112 2DL2*0010107 2DL5B*0020107 2DS3*0010302 2DP1*0010203 2DL1*007 3DP1*0030101 2DL4*00602 3DL1*0070102 Not present Not present Not present 2DS4*0040102 3DL2*008 partial sequence   View
LUCE   Bdel   3DL3*0140202 2DS2*0010108 2DL2*0030106 Not present Not present Not present Not present 3DP1*0090101 2DL4*00501 3DS1*0130101 2DL5A*0010103 2DS5*0020104 2DS1*0020103 Not present 3DL2*018   View
RPCI-1       3DL3*0030101 2DS2*0010101 2DL2*0030101 Not present Not present Not present Not present 3DP1*002 2DL4*00501 3DS1*0130101 2DL5A*0010101 2DS5*0020101 2DS1*0020101 Not present 3DL2*006/007   View
T7526   Bdel   3DL3*00801 2DS2*0010110 2DL2*0030107 Not present Not present Not present Not present 3DP1*0090103 2DL4*00501 3DS1*0130103 2DL5A*0050104 2DS3*0020102 2DS1*0020106 Not present 3DL2*0070102   View
FH05   B   3DL3*0030103 2DS2*0010105 2DL2*0010102 2DL5B*0020105 2DS3*0010301 2DP1*0010201 2DL1*0040101 3DP1*0030102 2DL4*00501 3DS1*0130101 2DL5A*0050101 2DS3*0020101 2DS1*0020104 Not present 3DL2*0070103   View
FH15   B   3DL3*00301 p 2DS2*0010105 2DL2*0010106 2DL5B*0020107 2DS3*0010301 2DP1*0010202 2DL1*0040101 3DP1*0030102 2DL4*00501 3DS1*0130101 2DL5A*0050101 2DS3*0020103 2DS1*0020104 Not present 3DL2*0070103   View
WT47   B   3DL3*0030102 2DS2*0010102 2DL2*0010101 2DL5B*0020103 2DS3*0010301 2DP1*0010201 2DL1*0040101 3DP1*0030101 2DL4*00501 3DS1*0130101 2DL5A*0010102 2DS5*0020102 2DS1*0020102 Not present 3DL2*0070101   View
                                         
Source   Haplotype   3DL3 2DS2 2DL2/3 2DL5B 2DS3/5 2DP1 2DL1 3DP1 2DL4 3DL1/S1 2DL5A 2DS3/5 2DS1 2DS4 3DL2   Sequence
                                         
Key       Framework gene
(can be activating,
inhibiting
or a pseudogene)
? Inhibitory gene ? Activating gene ? Pseudogene Not present Gene not present    

References

All references are linked to the PubMed abstract where possible.

  1. Hsu KC, Chida S, Geraghty DE, Dupont B. The killer cell immunoglobulin-like receptor (KIR) genomic region: gene-order, haplotypes and allelic polymorphism. Immunological Review (2002) 190:40-52 (Abstract)
  2. Pyo CW, Guethlein LA, Vu Q, Wang R, Abi-Rached L, Norman, PJ, Marsh SGE, Miller JS, Parham P, Geraghty DE. Different patterns of evolution in the centromeric and telomeric regions of group a and B haplotypes of the human killer cell Ig-like receptor locus. PLoS One (2010) 5:e15115 (Abstract)

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