DPB1 T-Cell Epitope Algorithm v1.0 (2012-04)

Classification of HLA-DPB1 mismatches based on T-cell-epitope groups has been shown to identify permissive mismatches and non-permissive mismatches for HLA-DPB1 after unrelated-donor haematopoietic stem cell transplantation (HSCT). Classification of HLA-DPB1 mismatches based on T-cell-epitope groups may identify mismatches that might be tolerated (permissive) and those that would increase risks (non-permissive) after transplantation. This calculator allows you to enter the HLA-DPB1 typing of a patient and donor and view the predicted T-Cell epitopes and resulting prediction of the effect of mismatching when selecting appropriate donors for HSCT recipients.

The implementation of the DPB1 T-Cell Epitope algorithm has been written in collaboration with Katharina Fleischhauer, San Raffaele Scientific Institute, Italy and Bronwen Shaw, Anthony Nolan Research Institute, UK.

 

Disclaimer - This tool is being offered as a tool to predict T-Cell epitope matching at DPB1 as reported in:

  • Fleischhauer K, Shaw BE, Gooley T, et al.
    Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study.
    Lancet Oncology (2012) 13:366-74
  • Crocchiolo R, Zino E, Vago L, et al.
    Nonpermissive HLA-DPB1 disparity is a significant independent risk factor for mortality after unrelated hematopoietic stem cell transplantation.
    Blood (2009) 114:1437-44.
  • Zino E, Vago L, Di Terlizzi S, et al.
    Frequency and targeted detection of HLA-DPB1 T cell epitope disparities relevant in unrelated hematopoietic stem cell transplantation.
    Biol Blood Marrow Transplant (2007) 13:1031-40.
  • Zino E, Frumento G, Marktel S, et al.
    A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation.
    Blood (2004) 103:1417-24.

No information entered into this tool is collected or stored on our servers.

 
Prospective HLA-DPB1 Typing
 DPB1*   DPB1* 
 DPB1*   DPB1* 

Add Further Donors
Do Not Add Further Donors
 DPB1*   DPB1* 
 DPB1*   DPB1* 
 DPB1*   DPB1* 
 DPB1*   DPB1* 

    

Please enter a valid DPB1 typing using the numerical allele code only, for example DPB1*01:01:01 would be entered as '01:01:01'. Ambiguous typings are not permitted and all alleles should be defined to at least two fields; i.e. '01:01' and not '01'. In cases of apparent homozygosity, the typing should be entered in both boxes, or an error will be reported. In the case of null alleles, these will be treated as homozygous for the expressed allele.

Further Information

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