DPB1 T-Cell Epitope Algorithm v1.0 (2012-04)
Classification of HLA-DPB1 mismatches based on T-cell-epitope groups has been shown to identify permissive mismatches and non-permissive mismatches for HLA-DPB1 after unrelated-donor haematopoietic stem cell transplantation (HSCT). Classification of HLA-DPB1 mismatches based on T-cell-epitope groups may identify mismatches that might be tolerated (permissive) and those that would increase risks (non-permissive) after transplantation. This calculator allows you to enter the HLA-DPB1 typing of a patient and donor and view the predicted T-Cell epitopes and resulting prediction of the effect of mismatching when selecting appropriate donors for HSCT recipients.
The implementation of the DPB1 T-Cell Epitope algorithm has been written in collaboration with Katharina Fleischhauer, San Raffaele Scientific Institute, Italy and Bronwen Shaw, Anthony Nolan Research Institute, UK.
Disclaimer - This tool is being offered as a tool to predict T-Cell epitope matching at DPB1 as reported in:
- Fleischhauer K, Shaw BE, Gooley T, et al.
Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study.
Lancet Oncology (2012) 13:366-74
- Crocchiolo R, Zino E, Vago L, et al.
Nonpermissive HLA-DPB1 disparity is a significant independent risk factor for mortality after unrelated hematopoietic stem cell transplantation.
Blood (2009) 114:1437-44.
- Zino E, Vago L, Di Terlizzi S, et al.
Frequency and targeted detection of HLA-DPB1 T cell epitope disparities relevant in unrelated hematopoietic stem cell transplantation.
Biol Blood Marrow Transplant (2007) 13:1031-40.
- Zino E, Frumento G, Marktel S, et al.
A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation.
Blood (2004) 103:1417-24.
No information entered into this tool is collected or stored on our servers.