DPB1 T-Cell Epitope Algorithms

Classification of HLA-DPB1 mismatches based on T-cell-epitope Groups (TCE-Groups) has been shown to identify mismatches that might be tolerated (permissive) and those that would increase risks (non-permissive) after unrelated-donor haematopoietic stem cell transplantation (HSCT). These calculators allows you to enter the HLA-DPB1 typing of a patient and donor and view the predicted T-Cell epitopes and resulting prediction of the effect of mismatching when selecting appropriate donors for HSCT recipients.

The implementations of the DPB1 T-Cell Epitope tools has been written in collaboration with Katharina Fleischhauer, University Hospital Essen, Germany and Bronwen Shaw, CIBMTR, USA.

There are currently two versions of the tool, please click on the appropriate link for the version you require:

  • Version 1.0 of the tool was originally added to the IPD-IMGT/HLA site in 2012. This tool has been extensively used and validated in a number of studies (1-7). To faciliate ongoing studies which continue to use this algorithm, the first version of this tool will remain online.
  • Version 2.0 of the tool has been updated following the recent publication by Crivello et al (8). This update uses a new methodology for assessing the TCE group, and some predicted groups differ to the first version of the tool. At the current time there are no further studies published using the new algorithm.

TCE Group Lists

The FTP and Github repositories provide a listing of the HLA-DPB1 T-Cell Epitope Group Assignments for DPB1 proteins. The assignments are taken from the algorithms used for the online tools provided on this page. The file formart is as follows;

  • DPB1 allele, DPB1 protein, Version 1 Assignment, Version 2 Assignment, Comments

Alleles which have yet to be assigned a TCE group using either version are left blank.

References

  1. Zino E, Frumento G, Marktel S, et al.
    A T-cell epitope encoded by a subset of HLA-DPB1 alleles determines nonpermissive mismatches for hematologic stem cell transplantation.
    Blood (2004) 103:1417-24.
  2. Zino E, Vago L, Di Terlizzi S, et al.
    Frequency and targeted detection of HLA-DPB1 T cell epitope disparities relevant in unrelated hematopoietic stem cell transplantation.
    Biol Blood Marrow Transplant (2007) 13:1031-40.
  3. Crocchiolo R, Zino E, Vago L, et al.
    Nonpermissive HLA-DPB1 disparity is a significant independent risk factor for mortality after unrelated hematopoietic stem cell transplantation.
    Blood (2009) 114:1437-44.
  4. Fleischhauer K, Shaw BE, Gooley T, et al.
    Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study.
    Lancet Oncology (2012) 13:366-74
  5. Shaw BE, Robinson J, Fleischhauer K, et al.
    Translating the HLA-DPB1 T-cell epitope-matching algorithm into clinical practice
    Bone Marrow Transplantation (2013) 48:1510–1512
  6. Fleischhauer K, Fernandez-Viña MA, Wang, et al.
    Risk associations between HLA-DPB1 T-cell epitope matching and outcome of unrelated hematopoietic cell transplantation are independent of HLA-DPA1.
    Bone Marrow Transplant. (2014) 49:1176-83
  7. Pidala J, Lee SJ, Ahn KW, et al.
    Nonpermissive HLA-DPB1 mismatch increases mortality after myeloablative unrelated allogeneic hematopoietic cell transplantation.
    Blood. (2014) 124:2596-606
  8. Crivello P, Zito L, Sizzano F, et al.
    The Impact of Amino Acid Variability on Alloreactivity Defines a Functional Distance Predictive of Permissive HLA-DPB1 Mismatches in Hematopoietic Stem Cell Transplantation
    Biol Blood Marrow Transplant (2015) 21:233-41.

Further Information

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