Version Report - 2.14.1 (2006-08)

The following changes have been made to Release 2.14.0 to address errors in the naming of the following sequences.

Deleted Sequences
Allele IPD-IMGT/HLA Acc No Date EMBL/Genbank Comments
A*0298 HLA02507 2006-04-30 AY897620
Sequence named in error and shown to be identical to A*0296 (Aug 06)
Cw*0422 HLA02592 2006-06-30 DQ648008
Sequence named in error and shown to be identical to Cw*0421 (Aug 06)

Version Report - 2.14.0 (2006-07)

Release 2.14.0 is the first to address the problem of representing alleles with aberrant splice sites to the reference sequence. We have previously not marked the exon borders for differently spliced alleles like A*0111N, A*03010102N, A*29010102N and B*44020102S. As a result of this in the current release the cDNA and protein sequences for the above alleles have been modified, for more details please see the Help Page on Splice Site Variants.


New Sequences
Allele IPD-IMGT/HLA Acc No Date EMBL/Genbank Comments
A*010104 HLA02540 2006-04-30 DQ485722
 
A*0120 HLA02537 2006-04-30 AM183561
 
A*0297 HLA02509 2006-04-30 DQ409217
 
A*0298 HLA02507 2006-04-30 AY897620
Deleted in Release 2.14.1
A*0299 HLA02529 2006-04-30 DQ465611
 
A*030105 HLA02576 2006-05-31 AM261460
 
A*0323 HLA02528 2006-04-30 DQ465612
 
A*0324 HLA02590 2006-05-31 DQ403156
DQ403157
 
A*1124 HLA02386 2005-11-23 AM114414
 
A*1127 HLA02530 2006-04-30 DQ465608
 
A*1128 HLA02533 2006-04-30 DQ473291
 
A*2463 HLA02524 2006-04-30 AB253623
 
A*2464 HLA02574 2006-05-31 AF030911
DQ523225
 
A*2465 HLA02608 2006-06-30 AM268430
 
A*2466 HLA02613 2006-06-30 DQ782329
 
A*2505 HLA02607 2006-06-30 DQ645957
 
A*2631 HLA02581 2006-05-31 DQ530236
 
A*3017 HLA02510 2006-04-30 DQ409216
 
A*68020102 HLA02508 2006-04-30 AM235886
 
A*6833 HLA02531 2006-04-30 DQ438173
DQ438174
DQ438175
 
A*6834 HLA02595 2006-06-30 DQ648004
 
A*9201 HLA02538 2006-04-30 DQ473292
 
A*9203 HLA02582 2006-05-31 DQ485737
 
B*0748 HLA02514 2006-04-30 DQ455017
 
B*0749N HLA02519 2006-04-30 AM236599
 
B*0750 HLA02560 2006-05-31 AM236590
 
B*0830N HLA02591 2006-06-30 DQ641496
 
B*1316 HLA02516 2006-04-30 DQ455015
 
B*2736 HLA02513 2006-04-30 DQ455018
DQ455019
 
B*350106 HLA02566 2006-05-31 DQ514598
 
B*3562 HLA02385 2005-11-23 AM114412
 
B*3712 HLA02532 2006-04-30 DQ473294
 
B*3814 HLA02584 2006-05-31 AM261745
 
B*3937 HLA02384 2005-11-23 AM114413
 
B*4066 HLA02536 2006-04-30 DQ181794
 
B*4067 HLA02588 2006-05-31 AB257503
 
B*4068 HLA02597 2006-06-30 DQ647703
 
B*4816 HLA02517 2006-04-30 DQ455014
DQ455014
 
B*5142 HLA02558 2006-05-31 AM260212
 
B*5210 HLA02585 2006-05-31 DQ537945
 
B*5521 HLA02518 2006-04-30 DQ455012
 
B*5522 HLA02539 2006-04-07 DQ458812
DQ458813
DQ458814
 
B*5617 HLA02565 2006-05-31 DQ514600
 
B*5812 HLA02512 2006-04-30 DQ455013
DQ455020
 
B*5813 HLA02596 2006-06-30 DQ648737
 
B*5902 HLA02589 2006-05-31 AB257504
 
B*9515 HLA02515 2006-04-30 DQ455016
 
B*9516 HLA02545 2006-04-30 AM259370
 
Cw*0215 HLA02559 2006-05-31 AM260635
 
Cw*0216 HLA02593 2006-06-30 DQ648007
 
Cw*030305 HLA02567 2006-05-31 DQ514597
 
Cw*030405 HLA02522 2006-04-30 DQ417102
DQ417103
 
Cw*0326 HLA02526 2006-04-30 AB253624
 
Cw*0327 HLA02594 2006-06-30 DQ648006
 
Cw*0328 HLA02599 2006-06-30 AB257505
 
Cw*0329 HLA02600 2006-06-30 AB257506
 
Cw*0419 HLA02511 2006-04-30 DQ453525
 
Cw*0420 HLA02525 2006-04-30 DQ417108
DQ417109
 
Cw*0421 HLA02578 2006-05-31 DQ525630
DQ648008
 
Cw*0422 HLA02592 2006-06-30 DQ648008
Deleted in Release 2.14.1
Cw*0514 HLA02586 2006-05-31 DQ535033
DQ535035
 
Cw*06020102 HLA02561 2006-05-31 DQ249182
Genomic sequence
Cw*070106 HLA02523 2006-04-30 DQ417104
DQ417105
 
Cw*070107 HLA02611 2006-06-30 DQ782328
 
Cw*0739 HLA02564 2006-05-31 DQ514599
 
Cw*1218 HLA02527 2006-04-30 DQ465613
 
Cw*1219 HLA02605 2006-06-30 AM261030
 
Cw*1408 HLA02427 2006-01-27 DQ314861
 
DPB1*1702 HLA02451 2006-02-22 DQ206450
DQ206450
DQ206450
 
DPB1*1902 HLA02579 2006-05-31 DQ485789
 
DQB1*060403 HLA02602 2006-06-30 DQ503425
 
DQB1*060802 HLA02609 2006-06-30 AM279416
 
DRB1*0330 HLA02603 2006-06-30 AM269468
 
DRB1*0331 HLA02606 2006-06-30 DQ666333
 
DRB1*0458 HLA02534 2006-04-28 DQ473290
 
DRB1*0459 HLA02580 2006-05-31 DQ525631
 
DRB1*115402 HLA02568 2006-05-31 DQ514604
 
DRB1*1156 HLA02577 2006-05-31 DQ525634
 
DRB1*1157 HLA02587 2006-05-31 DQ535034
 
DRB1*1215 HLA02583 2006-05-31 DQ533486
 
DRB1*1372 HLA02535 2006-04-28 DQ473293
 
DRB1*1373 HLA02570 2006-05-31 DQ514602
 
DRB1*1374 HLA02610 2006-06-30 AM279417
 
DRB1*1459 HLA02520 2006-04-28 AM233907
 
DRB1*1460 HLA02563 2006-05-31 AM259285
 
DRB1*1461 HLA02572 2006-05-31 DQ494324
 
DRB1*1462 HLA02612 2006-06-30 DQ782331
 
DRB1*150106 HLA02569 2006-05-31 DQ514601
DQ514603
 
DRB1*1520 HLA02571 2006-05-31 AM258966
 
DRB1*1521 HLA02573 2006-05-31 DQ525633
 
DRB1*1522 HLA02575 2006-05-31 DQ525632
 
H*01010101 HLA02546 2006-04-30 AF055066
CR388220
M32106
Genomic sequence
H*01010102 HLA02557 2006-04-30 X12432
Genomic sequence
H*01010103 HLA02548 2006-04-30 M31944
Genomic sequence
H*0102 HLA02551 2006-04-30 AL845454
Genomic sequence
H*02010101 HLA02547 2006-04-30 AB023057
AL671561
CT009496
Genomic sequence
H*02010102 HLA02549 2006-04-30 M96336
Genomic sequence
H*0202 HLA02556 2006-04-30 AC004194
BX927141
Genomic sequence
H*0203 HLA02550 2006-04-30 BX284699
Genomic sequence
H*0204 HLA02552 2006-04-30 AL645929
Genomic sequence
H*0205 HLA02554 2006-04-30 M32105
Genomic sequence
H*0206 HLA02555 2006-04-30 J00191
Genomic sequence
H*0301 HLA02553 2006-04-30 M32104
Genomic sequence
Sequences Pending
Allele IPD-IMGT/HLA Acc No Date EMBL/Genbank Comments
A*1129        
A*2629        
A*2630        
A*2915        
A*680105        
A*9202        
Cw*0740        
DRB1*0460        
Modified Sequences
Allele IPD-IMGT/HLA Acc No Date EMBL/Genbank Comments
A*0111N HLA02057 2005-01-31 AY574934
AY836150
The last 24 bases of exon 3 have been marked as removed from the CDS due to a mutation in the splice site that causes this exon to end prematurely.
Protein sequence modified.
A*03010102N HLA01718 2003-02-25 AJ532608
AM041067
AM041068
Sequence extended to include additional 62 bps due to mutation in the splice site at the end of exon 4.
Protein sequence modified.
A*260101 HLA00073 1989-08-01 AL845454
D16843
D32130
D32131
M24095
U03697
Genomic sequence added
A*29010102N HLA01406 2001-01-31 AJ293507
Sequence extended to include additional 65 bps due to mutation in the splice site at the end of exon 4.
Protein sequence modified.
B*0710 HLA00142 1998-07-28 AJ223602
AM236752
Sequence extended from position 620 to 895
B*0717 HLA01110 1999-11-18 AB256953
AF173936
Sequence extended from position 620 to 895
B*15010101 HLA00162 1989-08-01 AF436090
AJ295140
D50292
DQ249177
L48400
L79939
M28203
M83193
U03859
Genomic sequence extended to cover 5' UTR
B*15010102N HLA00163 1998-12-07 AJ250917
AM048844
Y17110
Genomic sequence has had 28 bps of primer sequence removed from gDNA positions -28 to -1
B*15170101 HLA00180 1993-08-09 AJ300181
U01848
U35431
Genomic sequence has had 28 bps of primer sequence removed from gDNA positions -28 to -1
B*3517 HLA00254 1995-11-16 AB256954
L49341
L75941
U34618
Sequence extended from position 620 to 895
B*380101 HLA00267 1989-08-01 DQ249175
DQ249179
L36591
M29864
U40498
Genomic sequence extended
B*40060101 HLA00297 1992-08-13 AJ300180
M95531
Genomic sequence has had 28 bps of primer sequence removed from gDNA positions -28 to -1
B*4402102S HLA01606 2002-05-31 AF384095 The nucleotide sequence of exon 5, positions 896 to 1012, has been removed from the CDS as it is not expressed due to a mutation in intron 4.
Protein sequence modified.
B*4446 HLA02343 2005-09-23 AM236591
DQ185396
Sequence extended from position 1 to 73 and position 620 to 1089
Genomic sequence extended
B*5001 HLA00341 1991-11-14; DQ249182
U11261
X61706
Genomic sequence extended
B*5610 HLA01658 2002-09-30 AB254370
AY134744
Sequence extended from position 620 to 895
B*7805 HLA01403 2000-12-18 AB051357
AB254369
Sequence extended from position 620 to 895
Cw*030401 HLA00413 1992-08-14 D64150
DQ249177
M99389
U31372
U31373
U44064
Genomic sequence added
Cw*06020101 HLA00430 1992-10-07 AJ420245
D64147
DQ249180
M28160
M28206
X70857
Z22752
Z22753
Z22754
Genomic sequence extended to cover 5' UTR
Cw*0802 HLA00446 1991-11-14 DQ249173
DQ249176
M59865
M84173
Genomic sequence extended
DRB1*1331 HLA00829 1997-03-06 DQ525629
U88133
U88134
* -> G, position 370
MICA*01802 HLA02034 2004-12-21 AJ580805
G -> *, position 70
MICA*053 HLA02334 2005-09-23 AJ871399
AJ871399
G -> *, position 70
MICB*015 HLA02075 2004-12-10 AJ563706
G -> *, position 70
Deleted Sequences
Allele IPD-IMGT/HLA Acc No Date EMBL/Genbank Comments
A*0298 HLA02507 2006-04-30 AY897620
Sequence named in error and shown to be identical to A*0296 (Aug 06)
Cw*020204 HLA00407 1997-03-19 U88838
U88839
U97346
U97347
Z96924
Sequence shown to be identical to Cw*0210 (Apr 06)
Cw*0422 HLA02592 2006-06-30 DQ648008
Sequence named in error and shown to be identical to Cw*0421 (Aug 06)

Further Information

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