HPA Allele Frequencies

The following tables give the frequencies of the HPA alleles.

The authors of these pages welcome submissions of HPA population data from any laboratory. If you would like to contribute data please send it to pmetcalfe@nibsc.ac.uk or naw23@cam.ac.uk.

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Additional Data

Country Laboratory Method Publication Ethnic origin Number

HPA Genes

HPA-1a HPA-1b HPA-2a HPA-2b HPA-3a HPA-3b HPA-4a HPA-4b HPA-5a HPA-5b HPA-6a HPA-6b HPA-15a HPA-15b

HPA Allele Frequencies

Country Laboratory Method Publication Ethnic origin Number HPA-1a HPA-1b HPA-2a HPA-2b HPA-3a HPA-3b HPA-4a HPA-4b HPA-5a HPA-5b HPA-6a HPA-6b HPA-15a HPA-15b
Argentina Servicio de Medicina Transfusional, Rosario, Argentina PCR-SSP De La Vega et al. Transfusion Medicine, 18:83-90, 2008 Argentinian 192 0.878 0.122 0.875 0.125 0.612 0.388 1 0 0.927 0.073 1 0 0.511 0.489
Servicio de Medicina Transfusional, Rosario, Argentina PCR-SSP De La Vega et al. Transfusion Medicine, 18:83-90, 2008 Amerindian toba 27 1 0 0.944 0.056 0.389 0.611 1 0 1 0 1 0 0.685 0.315
Austria Blood Group Serology, University of Vienna, Austria PCR-RFLP Holensteiner et al., Haemostasis, 25:133-136, 1995 Caucasoid of mixed background 911 0.852 0.148                        
Blood Group Serology, University of Vienna, Austria PCR-RFLP Holensteiner et al., Haemostasis, 25:133-136, 1995 Consecutive newborns 907     0.918 0.082                    
Blood Group Serology, University of Vienna, Austria PCR-RFLP Holensteiner et al., Haemostasis, 25:133-136, 1995 Consecutive newborns 906         0.612 0.388                
Blood Group Serology, University of Vienna, Austria PCR-RFLP Holensteiner et al., Haemostasis, 25:133-136, 1995 Consecutive newborns 100             1 0     1 0    
Blood Group Serology, University of Vienna, Austria PCR-RFLP   Consecutive newborns 931                 0.892 0.108        
Blood Group Serology, University of Vienna, Austria PCR-SSP (Fleisch)   Caucasoid adult platelet donors of the same mixed background 254                         0.5 0.5
Blood Group Serology, University of Vienna, Austria PCR-SSP   Additional Caucasoid blood donors from Vienna 965 0.845 0.155 0.899 0.101 0.603 0.397     0.911 0.089        
Austria/Styria UBT, Graz, Austria PCR-SSP (Domino System HPA  Protrans, Ketsch, Germany) Macher et al., The Hematology Journal, 5 S2, 2004 Caucasian 238 0.83 0.17 0.87 0.13 0.62 0.38     0.92 0.08        
Benin Platelet immunology INTS, Paris, France PCR-RFLP/SSP Hallé et al, Tissue Antigens, 65:295-98, 2005 Fon, Adja 154 0.896 0.104 0.708 0.292 0.679 0.321 1 0 0.818 0.182 1 0 0.646 0.354
Brazil Platelet Immunology, UNICAMP, Campinas, Brazil PCR-RFLP Castro et al., Eur J Immunogenet., 26:355-360, 1999 Caucasian 100 0.925 0.075 0.850 0.150 0.600 0.400 1 0 0.920 0.080        
Platelet Immunology, UNICAMP, Campinas, Brazil PCR-RFLP Castro et al., Eur J Immunogenet., 26:355-360, 1999 African-descents 150 0.903 0.097 0.810 0.190 0.666 0.334 1 0 0.876 0.124        
Platelet Immunology, UNICAMP, Campinas, Brazil PCR-RFLP Castro et al., Eur J Immunogenet., 26:355-360, 1999 Amazon Indians 70 1 0 0.821 0.179 0.757 0.243 1 0 1 0        
Platelet Immunology, UNICAMP, Campinas, Brazil PCR-SSP   Random blood donors 180                     1 0 0.444 0.556
Hospital Sirio Libanês, São Paulo, Brazil HPA-1,2,3,4,6,15: SSP / HPA-5: RFLP   "white" blood donors 400 0.78 0.22 0.9 0.1 0.63 0.37 1 0 0.91 0.09 1 0    
Hospital Sirio Libanês, São Paulo, Brazil HPA-1,2,3,4,6,15: SSP / HPA-5: RFLP   "white" blood donors 200                         0.3 0.7
Cameroon Platelet immunology INTS, Paris, France PCR-RFLP/SSP Hallé et al, Tissue Antigens, 65:295-98, 2005 Bamileke (80%), Duala, Beti 118 0.907 0.093 0.763 0.237 0.614 0.386 1 0 0.746 0.254 1 0 0.691 0.309
Central African Republic Platelet immunology INTS, Paris, France PCR-RFLP/SSP Hallé et al, Tissue Antigens, 65:295-98, 2005 Aka pygmies 110 1 0 0.607 0.393 0.5 0.5 1 0 0.595 0.405 1 0 0.698 0.302
China Shanghai  Institute of Blood Transfusion, Shanghai Blood Center PCR-SSP Feng et al, Transfusion Medicine, 16:369-74, 2006 Han Chinese 1000 0.994 0.006 0.952 0.0485 0.5945 0.4055 0.996 0.005 0.986 0.014 0.987 0.014 0.532 0.468
Blood Center of Zhejiang Province PCR-SBT Xu et al, Vox Sanguinis, 2009 Han Chinese 112 1 0 0.955 0.045 0.588 0.412 1 0 0.977 0.023 0.959 0.041 0.582 0.418
Jiangsu Province Blood Center PCR-SSP   Han Chinese 972 0.996 0.004 0.937 0.0628 0.567 0.434 0.999 0.001 0.987 0.013 0.986 0.014 0.507 0.493
Congo (Democratic Republic) Platelet immunology INTS, Paris, France PCR-RFLP/SSP Hallé et al, Tissue Antigens, 65:295-98, 2005 Bantu 125 0.904 0.096 0.776 0.224 0.596 0.404 1 0 0.732 0.268 1 0 0.701 0.299
Croatia Croatian Inst. of Transf. Med, Croatia PCR-SSP   Caucasian 430 0.83 0.17 0.88 0.12 0.64 0.36     0.89 0.11        
Croatian Inst. of Transf. Med, Croatia PCR-SSP   Caucasian 558                         0.53 0.47
Czech Republic IHBT, Prague, Czech Republic PCR-SSP Korinkova et al, Pediatric Research, 45:766, 1999 Caucasian 235 0.83 0.17 0.90 0.10 0.59 0.41     0.93 0.07        
Denmark Department of Clinical Immunology, Aalborg Hospital, Denmark PCR-RFLP Steffensen et al, Tissue Antigens, 48:93-96, 1998 Danish 557 0.83 0.17                        
Department of Clinical Immunology, Aalborg Hospital, Denmark PCR-SSO Steffensen et al, Tissue Antigens, 48:93-96, 1998 Danish 163     0.92 0.08 0.63 0.37                
Department of Clinical Immunology, Aalborg Hospital, Denmark PCR-SSO Steffensen et al, Tissue Antigens, 48:93-96, 1998 Danish 131             1.00 0            
Department of Clinical Immunology, Aalborg Hospital, Denmark PCR-SSP Steffensen et al, Tissue Antigens, 48:93-96, 1998 Danish 427                 0.92 0.08        
Department of Clinical Immunology, Aalborg Hospital, Denmark PCR-SSP   Danish 100                     1 0    
Department of Clinical Immunology, Aalborg Hospital, Denmark Local LightCycler   Danish 100                         0.50 0.50
French Polynesia Platelet Immunology, INTS, Paris, France PCR-RFLP/SSP Hallé et al, Tissue Antigens, 63:34-41, 2001 Ma'ohis 81 0.975 0.025 0.913 0.087 0.599 0.401 1 0 0.975 0.025 0.932 0.068 0.463 0.537
France Laboratory of Immunology, Nantes, France PCR-SSP   Caucasoid (local) 212 0.88 0.12                        
Laboratory of Immunology, Nantes, France PCR-SSP   Caucasoid (local) 211         0.65 0.35                
Laboratory of Immunology, Nantes, France PCR-SSP   Caucasoid (local 236                 0.83 0.17        
Platelet Immunology laboratory, EFS Rhône-Alpes, Lyon, France PCR SSP Mérieux, Pathologie biologie, 45:697-700, 1997 Caucasian. Random platelet donors 6192 0.848 0.152     0.62 0.38     0.874 0.126        
Platelet Immunology laboratory, EFS Rhône-Alpes, Lyon, France PCR SSP Mérieux, Pathologie biologie, 45:697-700, 1997 Caucasian. Random platelet donors 525     0.92 0.08                    
Platelet Immunology laboratory, EFS Rhône-Alpes, Lyon, France PCR SSP Mérieux, Pathologie biologie, 45:697-700, 1997 Caucasian. Random platelet donors 1242                         0.455 0.545
Platelet Immunology laboratory, EFS Rhône-Alpes, Lyon, France PCR SSP Mérieux, Pathologie biologie, 45:697-700, 1997 CD109(high level) platelet donors 83                         0.625 0.375
Germany Dept. Immunology and Transfusionmedicine, University of Greifswald, Germany PCR SSP Carlsson et al., Stroke, 28:1392-1395, 1997 Random blood donors, estimated 99% Caucasian 1583 0.84 0.16                        
Dept. Immunology and Transfusionmedicine, University of Greifswald, Germany PCR SSP Carlsson et al., Stroke, 28:1392-1395, 1997 Random blood donors, estimated 99% Caucasian 1576     0.93 0.07                    
Dept. Immunology and Transfusionmedicine, University of Greifswald, Germany PCR SSP Carlsson et al., Stroke, 28:1392-1395, 1997 Random blood donors, estimated 99% Caucasian 1562         0.6 0 0.40                
Dept. Immunology and Transfusionmedicine, University of Greifswald, Germany PCR SSP Carlsson et al., Stroke, 28:1392-1395, 1997 Random blood donors, estimated 99% Caucasian 1643                 0.92 0.08        
The Institute of Transfusion Medicine, University Clinic of Schleswig-Holstein, Germany PCR SSP Klüter et al., Vox Sanguinis, 71:121-125, 1996 (with minor modifications)
Caucasians from northern Germany 573 0.839 0.161 0.910 0.090 0.586 0.414     0.917 0.083        
Greece Medicanalysis Ltd, Greece PCR-SSP   Greek 58 0.67 0.33 0.75 0.25 0.405 0.595     0.85 0.15        
Ireland Dublin (NHIRL), Ireland PCR-SSP (NIBSC)   Irish 250 0.882 0.118 0.934 0.066 0.624 0.376 1 0 0.912 0.088     0.542 0.458
Italy SIT Alessandria, Italy PCR-SSP Mazzucco L et al., 6th Europ. Symp. Plat., Gran.& Red Cell Immunobiology. Amsterdam, 2000. Abstract Book, p 22. Caucasian 144 0.85 0.15 0.89 0.11 0.61 0.39 1 0 0.9 0.1 1 0    
Lebanon Molecular Pathology, American University of Beirut Medical Centre, Lebanon SSP / Reverse Hybridization Amira et al. Transfusion Medicine 17:473-8 2007 Caucasian 205 0.81 0.19                        
Luxembourg Laboratoire de Biologie et Physiologie Intégrée, Université du Luxembourg PCR-RFLP confirmed by Taqman Real-time PCR   Random Blood Donor 255 0.869 0.131 0.933 0.067 0.616 0.384     0.902 0.098        
Morocco HSP-Barcelona, Spain Kluter et al., Vox Sang, 71:121, 1996 Ferrer et al., Transfusion Medicine, 12:49-54, 2002 Berbers 107 0.748 0.252                        
HSP-Barcelona, Spain Kluter et al., Vox Sang, 71:121, 1996 Ferrer et al., Transfusion Medicine, 12:49-54, 2002 Berbers 107     0.818 0.182                    
HSP-Barcelona, Spain Kluter et al., Vox Sang, 71:121, 1996 Ferrer et al., Transfusion Medicine, 12:49-54, 2002 Berbers 104         0.682 0.318                
HSP-Barcelona, Spain Skogen et al., Transfusion, 34:955, 1994 Ferrer et al., Transfusion Medicine, 12:49-54, 2002 Berbers 108             1 0.00            
HSP-Barcelona, Spain Kluter et al., Vox Sang, 71:121, 1996 Ferrer et al., Transfusion Medicine, 12:49-54, 2002 Berbers 112                 0.861 0.139        
HSP-Barcelona, Spain Skogen et al., Transfusion, 34:955, 1994 Ferrer et al., Transfusion Medicine, 12:49-54, 2002 Berbers 108                     1 0    
Poland IH&BT Warsaw, Poland PCR SSP Drzewek et al., Transf Med. 8:339-342, 1998 (published numbers in parenthesis)  Caucasian 225 (135) 0.824 0.176                        
IH&BT Warsaw, Poland PCR SSP Drzewek et al., Transf Med. 8:339-342, 1998 (published numbers in parenthesis)  Caucasian 266 (211)     0.901 0.099                    
IH&BT Warsaw, Poland PCR SSP Drzewek et al., Transf Med. 8:339-342, 1998 (published numbers in parenthesis)  Caucasian 214 (130)         0.582 0.418                
IH&BT Warsaw, Poland PCR SSP Drzewek et al., Transf Med. 8:339-342, 1998 (published numbers in parenthesis)  Caucasian 106 (103)             1 0            
IH&BT Warsaw, Poland PCR SSP Drzewek et al., Transf Med. 8:339-342, 1998 (published numbers in parenthesis)  Caucasian 249 (166)                 0.944 0.056        
IH&BT Warsaw, Poland TaqMan   Caucasian 300                         0.485 0.515
Republic of Macedonia Institute of Immunobiology and Human Genetics (IIBHG), Faculty of Medicine, Skopje PCR-RFLP Pavkovic et al., Tissue Antigens, 67:241-246, 2006 Macedonian 122 0.865 0.135                        
Institute of Immunobiology and Human Genetics (IIBHG), Faculty of Medicine, Skopje PCR-RFLP Pavkovic et al., Tissue Antigens, 67:241-246, 2006 Macedonian 132     0.852 0.148                    
Institute of Immunobiology and Human Genetics (IIBHG), Faculty of Medicine, Skopje PCR-RFLP Pavkovic et al., Tissue Antigens, 67:241-246, 2006 Macedonian 115         0.578 0.422                
Institute of Immunobiology and Human Genetics (IIBHG), Faculty of Medicine, Skopje PCR-RFLP Pavkovic et al., Tissue Antigens, 67:241-246, 2006 Macedonian 126                 0.909 0.091        
Slovenia BTC Ljubljana, Slovenia Real-time PCR Rozman et al, Eur J Immunogenet., 26:265-269, 1999 Caucasian - Slovenian 152 0.832 0.168 0.899 0.101 0.667 0.333     0.892 0.108        
BTC Ljubljana, Slovenia Real-time PCR   Caucasian - Slovenian 90                         0.527 0.483
Spain HSP-Barcelona, Spain Kluter et al., Vox Sang, 71:121, 1996 Muñiz-Diaz et al., Haematologica, 83 S2 :162. 1998 (published numbers in parenthesis) Spanish 900 (727) 0.81 0.19                        
HSP-Barcelona, Spain Kluter et al., Vox Sang, 71:121, 1996 Muñiz-Diaz et al., Haematologica, 83 S2 :162. 1998 (published numbers in parenthesis) Spanish 500 (462)     0.90 0.10                    
HSP-Barcelona, Spain Kluter et al., Vox Sang, 71:121, 1996 Muñiz-Diaz et al., Haematologica, 83 S2 :162. 1998 (published numbers in parenthesis) Spanish 800 (662)         0.65 0.35                
HSP-Barcelona, Spain Skogen et al., Transfusion, 34:955, 1994 Muñiz-Diaz et al., Haematologica, 83 S2 :162. 1998 (published numbers in parenthesis) Spanish 300 (264)             1 0.00            
HSP-Barcelona, Spain Kluter et al., Vox Sang, 71:121, 1996 Muñiz-Diaz et al., Haematologica, 83 S2 :162. 1998 (published numbers in parenthesis) Spanish 600 (454)                 0.88 0.12        
HSP-Barcelona, Spain Skogen et al., Transfusion, 34:955, 1994 Muñiz-Diaz et al., Haematologica, 83 S2 :162. 1998 (published numbers in parenthesis) Spanish 300 (254)                     1 0    
HSP-Barcelona, Spain Schuh et al., Blood, 99:1692, 2002 Muniz-Diaz et al., Platelets, 15:258, 2004 Spanish 385                         0.474 0.526
Switzerland Haemostasis Unit, HUG, Switzerland PCR amplification with the Domino System (Protrans, Endotell AG, Allschwill, Switzerland)
Boehlen et al., The Hematology Journal, 4:441-444, 2003
Caucasian for 99% 500 0.809 0.191 0.918 0.109 0.591 0.407 0.997 0.000 0.934 0.066        
Taiwan Taipei VGH PCR-SSP   Chinese 300 0.9967 0.0033 0.96 0.04 0.575 0.425 0.9983 0.0017 0.985 0.015 0.9633 0.0367    
Tunisian Platelet Immunology, INTS, Paris, France PCR-RFLP Mojaat et al, Tissue Antigens, 54:201-204, 1999   90 0.75 0.25     0.694 0.306     0.779 0.221        
USA BCSEW, USA Allele-specific PCR   Caucasian 1013                            
Vietnam Platelet Immunology, INTS, France PCR-RFLP/SSP Hallé et al, Tissue Antigens, 63:34-41, 2001 Kinh 107 0.986 0.014 0.953 0.047 0.486 0.514 1 0 0.972 0.028 0.986 0.014 0.477 0.523
Wales Welsh Transplantation & Immunogenetics Lab, Wales PCR-SSP Sellers et al., Eur J Immunogenet., 26:393–397, 1999 Northern European Caucasoid 392 0.8253 0.1747 0.9018 0.0982 0.6071 0.3929 1 0            
Welsh Transplantation & Immunogenetics Lab, Wales PCR-SSP   Northern European Caucasoid 339                 0.9027 0.0973        
Welsh Transplantation & Immunogenetics Lab, Wales PCR-SSP   Northern European Caucasoid 166                     1 0    
Welsh Transplantation & Immunogenetics Lab, Wales PCR-SSP Downing et al., Abstract awaiting publication Northern European Caucasoid 166                         0.5241 0.4759

 

IPD-HPA