{"metadata":{"accession":"P62593","id":"BLAT_ECOLX","source_organism":{"taxId":"562","scientificName":"Escherichia coli","fullName":"Escherichia coli"},"name":"Beta-lactamase TEM","description":["TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors"],"length":286,"sequence":"MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW","proteome":null,"gene":"blaT-6","go_terms":[{"identifier":"GO:0008800","name":"beta-lactamase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0017001","name":"antibiotic catabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0030655","name":"beta-lactam antibiotic catabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0046677","name":"response to antibiotic","category":{"code":"P","name":"biological_process"}}],"protein_evidence":1,"source_database":"reviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"4ab5c48e30574469cfafc0451da3679955b43a52","counters":{"domain_architectures":30140,"entries":13,"isoforms":0,"proteomes":0,"sets":1,"structures":78,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"ncbifam":2,"panther":1,"prosite":1,"prints":1,"interpro":5},"proteome":0,"taxonomy":1,"similar_proteins":30140}}}