{"metadata":{"accession":"W5VX16","id":"W5VX16_9PSEU","source_organism":{"taxId":"1449976","scientificName":"Kutzneria albida DSM 43870","fullName":"Kutzneria albida DSM 43870"},"name":"Chromosomal replication initiator protein DnaA","description":["Plays an essential role in the initiation and regulation of chromosomal replication. ATP-DnaA binds to the origin of replication (oriC) to initiate formation of the DNA replication initiation complex once per cell cycle. Binds the DnaA box (a 9 base pair repeat at the origin) and separates the double-stranded (ds)DNA. Forms a right-handed helical filament on oriC DNA; dsDNA binds to the exterior of the filament while single-stranded (ss)DNA is stabiized in the filament's interior. The ATP-DnaA-oriC complex binds and stabilizes one strand of the AT-rich DNA unwinding element (DUE), permitting loading of DNA polymerase. After initiation quickly degrades to an ADP-DnaA complex that is not apt for DNA replication. Binds acidic phospholipids"],"length":517,"sequence":"MSDDQTNLGQVWDQVVQELLAAGALSSLQRAWMRVTRPIGLLDGTVLLGAPSDFAKEAIERALRDPITAALSRRLNRPVSLAVKVDTVVPPAASTPPPVPQPPPLNGSPRPPAVAPMEQTAPMPAIPAEDSSAAEDDDATEVDEEREALATVHEIWPTFSGNPAVQPSSQTNSQTRLNEKYTFETFVIGASNRFAHAAAVAVAEAPARAYNPLFIWGESGLGKTHLLHAVGHYAQRLFPGMRVRYVSTEEFTNDFINSLRDDRKVAFQRRYRDIDVLLVDDIQFLEGKEGTQEEFFHTFNTLHNANKQIVVSSDRPPKRLETLEDRLRTRFEWGLITDIQPPELETRIAILRKKAAQDRLAAPAEVLEFIAARIERNIRELEGALIRVTAFASLNRQPVDVQLAEIVLRDLIPDSHAPEITAPTIMAVTAEFFGVSIDDLCGPGKTKALAQARQISMYLCRELTDLSLPKIGQTFGGRDHTTVMHADKKIRKEMAERRRIYDQVQELTSRIKQRARS","proteome":"UP000019225","gene":"dnaA","go_terms":[{"identifier":"GO:0043565","name":"sequence-specific DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006270","name":"DNA replication initiation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0006275","name":"regulation of DNA replication","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003688","name":"DNA replication origin binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"01c842fd60cc966e322d50f3ea73d76e0237381e","counters":{"domain_architectures":7479,"entries":27,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":4,"ssf":2,"pfam":2,"smart":2,"cdd":2,"panther":1,"hamap":1,"ncbifam":2,"prosite":1,"prints":1,"interpro":9},"proteome":1,"taxonomy":1,"similar_proteins":7479}}}